35 Burst results for "prostate cancer"

"prostate cancer" Discussed on Who Cares About Men's Health?

Who Cares About Men's Health?

05:12 min | Last week

"prostate cancer" Discussed on Who Cares About Men's Health?

"The try because we have a doctor here. Who's in a recognized authority. And he's an opinion leader. Like people look to dr toward regarding treating prostate cancers. We could play a little game yup for a game. I'm always right so this game is called. What do you know about the prostate and prostate cancer. Who questions. I'm answering Well i thought i would start okay. I'd i'd start by throwing out something i know like. For example what is the prostate. What do i know about it. It gets cancer. That's about all i know. Good start so this episode of who cares about men's health is one of our men's health essentials episodes and we're talking about prostate cancer and this is an important episode because as a man. If you understand this condition it can help. You have an informed conversation with an expert if you do need to to task or not what it means. If a test comes back positive what choices you might have if it does come back positive and it can really impact your lifestyle so with me as as always co host. Dr troy matteson. Say troy scott and dr jonathan toward from huntsman cancer institute. Thank you for having me and i'm scott. Sing pill people ask. What do you contribute. I'm here to ask the dumb question so our listeners don't have to. That's my job. Dr toward what is the prostate anyway. Well i mean the tongue in cheek answer is a gland. That's designed to make your life miserable as you get older. But but actually what. The prostate gland is a little gland that sits between the base of the penis inside your body and blow the bladder and the aretha actually runs through it and what its function. As it has a fertility roll it produces the fluid that A man would ejaculate and helps keep the sperm alive on the way to the partner so It's important for fertility but if you're done with that that particular aspect of your life It no longer is i. Guess a functionally necessary..

prostate cancers prostate cancer Dr troy matteson troy scott dr jonathan huntsman cancer institute cancer scott
James Michael Tyler, Gunther on 'Friends,' Reveals He Has Cancer

Mojo In The Morning

00:50 sec | Last month

James Michael Tyler, Gunther on 'Friends,' Reveals He Has Cancer

"If you are a fan the actor who played gutter on a show. James michael tyler. Just announced some really sad news on the today. Show says he's battling stage four prostate cancer. Which has left his lower body completely paralyzed and he said his illnesses worsening spread to his bones at this point and that's what left him unable to attend the friends reunion. Hbo max that's why he called into the special via zoom but he said the cancer started mutating at the beginning of the pandemic and the it progressed after he missed a doctor's appointment so he is undergoing chemotherapy right now and he said my goal. This past year was to see my fifty ninth birthday. I did that on. May twenty eighth. He said my goal now is to help. Save at least one life out with this news.

James Michael Tyler Prostate Cancer HBO Cancer
'Next Big Wave': Radiation Drugs Track and Kill Cancer Cells

AP News Radio

00:46 sec | Last month

'Next Big Wave': Radiation Drugs Track and Kill Cancer Cells

"Doctors reported promising results from an experimental cancer drug that delivers radiation directly to tumor cells an emerging class of medicine called radio pharmaceuticals may become a new way to treat patients with hard to reach inoperable cancers in a study involving over eight hundred men with advanced prostate cancer released by the American society of clinical oncology a tumor targeting radiation therapy from drug maker Novartis kept cancer at bay for nearly nine months compared to three months for people receiving standard treatment and survival was better to fifteen months versus eleven months the drug is administered through an IV in each dose contains trillions of engineered molecules a tractor portion of the molecule hunts down cancer cells the payload portion is the radiation experts say radio pharmaceuticals maybe the next big wave of therapeutic development I'm Jennifer king

Experimental Cancer Inoperable Cancers American Society Of Clinical O Prostate Cancer Novartis Cancer Jennifer King
Voice of Disney's 'Sebastian the Crab' Dies at Age 72

AP News Radio

00:56 sec | 2 months ago

Voice of Disney's 'Sebastian the Crab' Dies at Age 72

"Sinewy right the Tony nominated actor famous is the voice of Sebastian the crab has died really right had an acting career spanning five decades after moving to New York he made his name on Broadway replacing Ben Farina and Pippen it was an original cast member of Jesus Christ Superstar in the nineteen seventies right played the purple grape in the fruit of the loom commercials right on only a dollar he played chronic wanted on from Disney's dinosaur but was best known as Sebastian the crab in Disney's little mermaid and won a Grammy for Best Original Song in may two thousand interview Wright said he enjoyed speaking for Disney characters I'm in seventh heaven and I don't and I know it sounds like all he's just giving us the press the you know the old sound bite no really really this is what I've always wanted to do one of Wright's daughters D. Kelly wrote on Facebook my beautiful strong loving Daddy is off to his next adventure right was seventy two according to his family he died Monday in New York after a three year bout with prostate cancer I'm Jennifer king

Ben Farina Jesus Christ Superstar In The Sebastian The Crab In Disney's Pippen Sebastian Disney Tony Wright New York Grammy D. Kelly Daddy Facebook Prostate Cancer Jennifer King
Doctors Urge People To Keep Up With Their Routine Screenings

WBZ Afternoon News

01:02 min | 4 months ago

Doctors Urge People To Keep Up With Their Routine Screenings

"About the consequences of Americans putting off doctor's appointments and early detection screenings because of covert 19 WBZ is Kim Tunnicliffe tells US a Boston based nonprofit is launching a public awareness campaign urging men to start going for their prostate cancer screenings again. The prostate Health Education Network believes a crisis is looming for African American men in the U. S. President Thomas Farrington is concerned. The pandemic has cause meant to put off their early detection screenings, he says. The American Cancer Society is estimating that new prostate cancer cases will increase by 30% this year in American Man of the highest isn't afraid so there's more than 70% high for all other bands and die at a rate of more than 120% higher with they expected estimated you increases we see a major crisis, the network is teaming up with politicians. Energy and doctors to speak out about the importance of scheduling those early detection screenings. Kim Tunnicliffe WBZ

WBZ Kim Tunnicliffe Prostate Health Education Netw S. President Thomas Farrington Prostate Cancer Boston U. American Cancer Society
Why Fans and Nearly 600 Jeopardy Contestants Are Slamming Dr. Oz as Guest Host

Mark Blazor

01:24 min | 4 months ago

Why Fans and Nearly 600 Jeopardy Contestants Are Slamming Dr. Oz as Guest Host

"What? Dr Oz out as guest host on jeopardy. I guess that was quick. Last night was the first time he's hosted right last night was the very first one. Well, I guess they're protesting his gig as the guest host eyes two week run. He's supposed to do this for two week. They're accusing him of dangerous and UN researched medical claims. What has he given medical advice during jeopardy? No, you just You know, some of the things he's had on his show over the years have been more of a holistic approach instead of pure modern medicine, quote unquote. So they're saying the fact that this is a Fact based game show is a slap in the face to all involved having him hosted. I guess like you were just kind of alluding to that, you know. Some of the stuff he's done in the past might not be by the medical book. If you Will that holistic, some of that kind of thing. It sounds like you know, he does a blend. I guess he does. He doesn't blend and that's I don't think it's a bit. I don't think it's a bad thing. I really don't our own the governor Dimitri's Stanley on Friday he has done a combination of Modern scientist. Whatever you wanna call it, modern medicine for you know, with his battle with prostate cancer and some holistic stuff, and he's doing friend Fantastic right now. So what? I don't understand why people freak out about that?

Dr Oz UN Dimitri Stanley Prostate Cancer
Pinning Down Prostate Cancer

Medicine, We're Still Practicing

06:31 min | 5 months ago

Pinning Down Prostate Cancer

"Well i of course. Our hosts quadruple board. Certified doctor of internal medicine pulmonary disease critical care and neuro critical care and still fighting on the frontlines over the war on. Covid my very good friend. Dr steven tae back. How you doing steve. I'm well thank you as you've heard joining us from johns hopkins medicine. Doctor kenneth pinta. He's the director of research for the james buchanan. Brady urological institute. He's the co director prostate cancer research program for the sidney kimmel cancer center. He's a professor of urology. He's a professor of oncology. he's a professor of pharmacology and molecular sciences. Welcome dr to. What do you do with all your spare time can. This is not meant to be a softball question. But it's going to sound that way. I'm trying to understand from your inside. Perspective. what is it about the environment you work in a johns hopkins that produces these kind of outcomes. These ratings and the international recognition part of it is tradition. Johns hopkins was founded as the first research university in the united states and we've always placed the tripartite mention of patient care education to students and research on equal footing. So that we're always seamlessly combining those and the other piece of tradition is johns hopkins hospital in the medical school itself. We defined american medicine at johns hopkins with william oastler. Starting out saying we're gonna do medicine differently. Use the term. Medical residents started at johns hopkins. Because ostler made. The doctors live in the hospital to be trained in. So that's where the term came from. You know we have this dome at the hospital. With with the wings of the building and medicine rounds what referred to the fact that they would go round and round the dome to the different wards. And you know we carry that sort of tradition with pride and people love to work there and we've always attracted really smart people who love madison in love taking care of people and really love combining that with the research that powers the next generation of medicines. Forward dr parton. Your department chair talked about. While other hospitals use reports for urological surgery hopkins actually makes their own. Robots isn't making davinci robot. No we use a commercial robots like everyone else but what we are doing is creating the next generation of robots to work with mri machines. We have danced in. Our department is making a special robot that does that. The hopkins whiting school of engineering is developing the next generation of robots to integrate imaging with robotic surgery. A lot of that is not just hardware. it's software we're living in a pretty high tech era. We've come a long way in medicine but still so many men die of prostate cancer. What are we messing up here in. We have to do to fix this. So you know in this time of covid and so many people dying of kobe. You know it's an infectious disease. We gotta do better and we tend to forget about these other illnesses that are plaguing the planet you know if you look around the world. Ten million people a year are dying of cancer in the us. Six hundred thousand people are dying of cancer. Thirty thousand men die of prostate cancer. Every year and cancer of all kinds including prostate cancer is curable if you find it in time because we can do surgery or radiation in jewelry you but unfortunately in about fifty thousand men per year we find the cancer too late. We find the cancer. After it is escape the prostate and metastatic cancer virtually of all kinds is incurable and prostate cancer. Unfortunately metastasized spreads to the bones as first sight and it causes a lot of problems for guys in the bones including pain and eventually kills them and we can talk about how that happens but essentially we fail because we don't cure people because we don't find the cancer in time. Let me ask you a question about that. Actually because i've been quoted by colleagues that if you're fifty years old you have a fifty percent chance that you actually have prostate cancer and at sixty sixty percent chance that you've probably already have prostate cancer and so on and so forth and it would beg the question. Would it not make sense to prophylactically. Remove the prostate. And then obviously the the major impediment to that is the major side effects. What does the thought process about that in. Where are we in terms technologically of mitigating the terrible side effects of impotence and incontinence. So i think there's two aspects to that question steve that we just need to touch on because the other thing you hear. All the time is that oh prostate cancer. You don't have to worry about it. You're going to die with it not from it. You know we do see that. Eighty percent man age eighty if you look in their prostates. If they've gotten killed by a car accident you'll see prostate cancer. So essentially prostate cancer exists in two forms one form. Is this indolent slow growing low grade cancer. That probably shouldn't even be called the cancer. But it still is in we find it by screening and and those are the guys that can be treated with active surveillance. We don't need to treat their cancers where a lot smarter about that now than we were even a few years ago. The other kind of cancer is the aggressive prostate cancer. That is not the kind you find on all types whereas the kind that's growing quickly that we have to get out before it spreads so prostate cancer is definitely has a hereditary component. If you have a father or an uncle who had prostate cancer your your risk of developing prostate cancer is double if you have to family members. It's quadruples you had three family members. You're gonna get it so it is familial. There are some genetic drivers. Like vr rca to that lead to a higher incidence of prostate cancer. And we definitely say if you've have family history us should start screening sooner.

Prostate Cancer Pulmonary Disease Dr Steven Tae Cancers Kenneth Pinta Brady Urological Institute Sidney Kimmel Cancer Center First Research University William Oastler Johns Hopkins Dr Parton Johns Hopkins Medicine James Buchanan Hopkins Whiting School Of Engi Johns Hopkins Hospital Ostler Metastatic Cancer Steve
UK strips China's state media channel of broadcast license

Marketplace

03:33 min | 6 months ago

UK strips China's state media channel of broadcast license

"China has been recent years trying to improve its global image. That effort took a hit today in London, Britain's communications regulator announced it is stripping the state run China Global Television network of its broadcast license there, MPR's Frank Langfitt explains from London. The C GT N That's it's known, opened its European production center here to great fanfare about two years ago. Today off come, the British regulator announced it was pulling the network's license. Officials said. The reason was straightforward. The people in charge of CG Tien's editorial policy are ultimately beholden to China's Communist Party in British Broadcasting law forbids political bodies from controlling license holders. Thank goodness, Finally, this license has been taken away. Peter Humphrey, performer fraud investigator in Shanghai was glad to hear the news. He filed a complaint against CGT in last year. Not over Communist Party control of the network. But over Chinese state media is airing of what Humphrey says was a forced confession. It followed his arrest in 2000 and 13 on charges of illegally acquiring the personal data of Chinese nationals. Well, of course you go way up 10 personal information by illegal means. I regret what I did and apologize to the Chinese government. Humphrey insists he never actually confessed and that the interview was doctored. He also says his captors pressured him to make a statement by withholding medical treatment for his prostate cancer, considering the kind of brutal human rights violations that CD Tien has been involved with extracting and packaging forced confessions from prisoners held under torture in China, who've never been in front of a judge. I just think that we should have no organization like that on our soil in Humphries case, Afghan found CGT And had seriously breached fairness and privacy rules. It also found the network had failed to cover the Hong Kong democracy protests with quote due impartiality CG Tien was indignant with today's ruling. It blamed quote the manipulation of far right groups and had I China forces for the off calm decision, according to a statement on way ball, China's nearest equivalent Twitter. The loss of the license undermined two key Chinese government strategy. Steve saying is director of the so as China Institute at the School of Oriental and African Studies. University of London. She camping has been very clear he wants the Chinese story being told well. He wants his versions off everything being spread across the world in the most positive, light possible Sititi and is one of those instruments used for this purpose. It's hang expects the Chinese government to retaliate against BBC reporters in China. Even though the BBC is editorial independent of the British government. Peter Dahlin is the director of Safeguard Defenders Human Rights Organization, which spearheaded the campaign against C G. T n Here. The U. K stands out across Europe is having a quite well developed framework for help to regulate TV for how to control this information. The stripping of the license prohibits CG Tan from broadcasting here, but dollars, says that doesn't mean the network has to leave. Still, he does think today's move could have ripple effects are other countries going to start holding them accountable as well? I say this might be the beginning of a process that city and will find very unfavorable for their type of this information for their type of broadcasting. That would mean more challenges for a Chinese government that has invested a lot in trying to change the way it's perceived. Frank Langfitt NPR NEWS

Cg Tien China Chinese Government Frank Langfitt European Production Center Peter Humphrey Communist Party Humphrey London CGT China Institute Britain Tien Shanghai Humphries Prostate Cancer Peter Dahlin School Of Oriental And African Safeguard Defenders Human Righ BBC
Barry Lopez, Acclaimed Author And Traveler Beyond Many Horizons, Dies At 75

Environment: NPR

04:27 min | 7 months ago

Barry Lopez, Acclaimed Author And Traveler Beyond Many Horizons, Dies At 75

"National book award winner berry lopez was famous for chronicling his travels to remote places and the landscapes he found there but his writings weren't simply account of his journeys they were reminders of how precious life on earth is an our responsibility to care for it. He died after a long battle with prostate cancer just months. After a wildfire forced him from his oregon home he was seventy five years old. Npr's dave blanchard has this remembrance berry lopez spent more than thirty years writing his last book horizon. He don't spend that much time on a project without going through periods of self doubt when i met him at his home last year he told me when he was feeling defeated by the work. He'd walk along the nearby mckenzie river. Every time i did there was a beaver. Stick in the water at my feet. And they're of course their workers. So i imagine the beaver were saying. What the hell's wrong with you. You get back in there and do your work up. In his studio he had a collection of the stakes are little tooth marks. It was a lesson for lopez. Every day i walked in that room. I saw the signs of. Don't lose in yourself. This was the world of barry. Lopez beaver could teach you the most valuable lessons. Lopez was born in new york but his father moved the family to california when he was a child. Hugh eventually settle in game. Notice for his writing about the natural world he win the nineteen eighty-six book award for nonfiction. Work arctic dreams at the time he told npr how he approached the seemingly empty arctic environment. I made myself pay attention to places where i thought nothing was going on. And then after a while the landscape materialized in a in a fuller way denied. I imagine that at first glance in lopez books. A cloudy sky contains grays of pigeon feathers of slate in pearls packs of hammerhead sharks in the galapagos. Move like swans million a city park pond composer john. Luther adams was a friend and collaborator of lopez. For nearly four decades he says lopez writing serves as a wake-up call. She surveys the beauty of the world. And at the same time the cruelty and violence that we humans inflict on the earth and on one another and he doesn't with deep compassion lopez experienced that cruelty first hand as a child. He was sexually abused by a family. Friend he i wrote about it in two thousand thirteen. He later told. Npr experience made him feel afraid and shameful around other people. The animals encountered in the california wilderness. Offered something different. They didn't say oh. We know what you went through. I felt accepted by the animal world. Lopez would spend his life writing about that world in particular the damage done to it by climate change. That hit home for lopez. This past september much of his property was burned in wildfires tore through oregon partly due to abnormally dry conditions. His wife deborah gordon says he lost decades of notes and correspondence and much of the forest around the home where lopez had lived for fifty years. He talked a lot about climate change in. And how it's so easy to think it's going to happen to other people and not to you but it happened to us. It happened to him personally. And i think that the fire was just a blow. That not just couldn't quite ever get back from when i spoke to lopez last year. He said he always sought to find. Grace in the middle of devastation is so difficult to be a human being. There are so many reasons to give up to retreat into cynicism or despair. I hate to see that. And i i want to do something that makes people feel safe and loved and capable in his last days. His family brought objects from home to him in hospice. Among the items the beaver stakes from his studio dave blanchard. Npr news

Berry Lopez Lopez Dave Blanchard Lopez Beaver NPR Mckenzie River Luther Adams Oregon Prostate Cancer California Hugh Barry Arctic Deborah Gordon New York John Grace Npr News
Longtime MD Senate President Mike Miller Resigns Seat, Citing Health

WTOP 24 Hour News

00:58 sec | 7 months ago

Longtime MD Senate President Mike Miller Resigns Seat, Citing Health

"After a career in the Annapolis statehouse that spanned nearly five decades. Maryland's former Senate president, Thomas Mike Miller, has resigned. The 78 year old state senator who served 33 years, a Senate president in Annapolis, Thomas, Mike Miller, announced in the letter. He's resigning from his Senate seat effective today. Miller said He made the move with tremendous sadness, but cited his health He's been dealing with prostate cancer in recent years and said he felt he couldn't meet the demands of another legislative session. Even during heated debates. Miller, a Democrat, often had the respect of Republican lawmakers, who sometimes grudgingly would say he made sure they were heard in the legislative process. Miller's seat one that covers parts of Prince George's. Calvert and Charles counties will remain vacant until the Democratic Central Committee's in all three counties send a recommendation to Governor Larry Hogan governor then gets to make the appointment. General Assembly will convene

Thomas Mike Miller Senate Annapolis Miller Mike Miller Maryland Thomas Prostate Cancer Democratic Central Committee Prince George Calvert Governor Larry Hogan Charles General Assembly
Giuliani deemed high risk for complications from the coronavirus

First Morning News

00:55 sec | 8 months ago

Giuliani deemed high risk for complications from the coronavirus

"Giuliani Giuliani says says he's he's feeling feeling okay okay is is he he battles battles coronavirus coronavirus that that in in Washington, Washington, D. D. C C hospital they 76 year old Giuliani, currently the president's personal lawyer who's admitted to Georgetown Hospital on Sunday, Learning the president's personal lawyer, Rudy Giuliani, has been hospitalized at Georgetown University Medical Center here in Washington, D. C. After testing positive for covert 19. His conditions is unclear. But we do know that Rudy Giuliani is 76 years old. He is considered high risk and he does have a history of health complications, including a battle with prostate cancer. In recent weeks, he has been crisscrossing the country, leading the president's fight to overturn the results of the 2020 election. Just Thursday, Rudy Giuliani was in Georgia, asking state lawmakers there to overturn the November election. Giuliani son Andrew also came down with coronavirus in late November. He works at the White House. Speaking

Giuliani Giuliani D. D. C C Hospital Rudy Giuliani Georgetown Hospital Washington Giuliani Georgetown University Medical Prostate Cancer Georgia Andrew White House
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The Sheepdog Project

00:30 sec | 8 months ago

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"There's no predilection to cost prostate cancer from To cause a more severe form prostate cancer while on testosterone supplementation. It can increase your predilection for more treatable. Form of prostate cancer Obviously anybody on testosterone supplementation. You need to be having your test dot your prostate monitored as well and i'm gonna talk more about them. We genital urinary

Prostate Cancer
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The Sheepdog Project

00:30 sec | 8 months ago

test1

"There's no predilection to cost prostate cancer from To cause a more severe form prostate cancer while on testosterone supplementation. It can increase your predilection for more treatable. Form of prostate cancer Obviously anybody on testosterone supplementation. You need to be having your test dot your prostate monitored as well and i'm gonna talk more about them. We genital urinary

Prostate Cancer
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The Sheepdog Project

00:30 sec | 8 months ago

test

"There's no predilection to cost prostate cancer from To cause a more severe form prostate cancer while on testosterone supplementation. It can increase your predilection for more treatable. Form of prostate cancer Obviously anybody on testosterone supplementation. You need to be having your test dot your prostate monitored as well and i'm gonna talk more about them. We genital urinary

Prostate Cancer
test

The Sheepdog Project

00:30 sec | 8 months ago

test

"There's no predilection to cost prostate cancer from To cause a more severe form prostate cancer while on testosterone supplementation. It can increase your predilection for more treatable. Form of prostate cancer Obviously anybody on testosterone supplementation. You need to be having your test dot your prostate monitored as well and i'm gonna talk more about them. We genital urinary

Prostate Cancer
test2

The Sheepdog Project

00:30 sec | 8 months ago

test2

"There's no predilection to cost prostate cancer from To cause a more severe form prostate cancer while on testosterone supplementation. It can increase your predilection for more treatable. Form of prostate cancer Obviously anybody on testosterone supplementation. You need to be having your test dot your prostate monitored as well and i'm gonna talk more about them. We genital urinary

Prostate Cancer
test

The Sheepdog Project

00:30 sec | 8 months ago

test

"There's no predilection to cost prostate cancer from To cause a more severe form prostate cancer while on testosterone supplementation. It can increase your predilection for more treatable. Form of prostate cancer Obviously anybody on testosterone supplementation. You need to be having your test dot your prostate monitored as well and i'm gonna talk more about them. We genital urinary

Prostate Cancer
test

The Sheepdog Project

00:30 sec | 8 months ago

test

"There's no predilection to cost prostate cancer from To cause a more severe form prostate cancer while on testosterone supplementation. It can increase your predilection for more treatable. Form of prostate cancer Obviously anybody on testosterone supplementation. You need to be having your test dot your prostate monitored as well and i'm gonna talk more about them. We genital urinary

Prostate Cancer
test

The Sheepdog Project

00:30 sec | 8 months ago

test

"There's no predilection to cost prostate cancer from To cause a more severe form prostate cancer while on testosterone supplementation. It can increase your predilection for more treatable. Form of prostate cancer Obviously anybody on testosterone supplementation. You need to be having your test dot your prostate monitored as well and i'm gonna talk more about them. We genital urinary

Prostate Cancer
"prostate cancer" Discussed on Mayo Clinic Q&A

Mayo Clinic Q&A

03:35 min | 9 months ago

"prostate cancer" Discussed on Mayo Clinic Q&A

"When diagnosed with this type of cancer of course when the cancer is more advanced than we certainly taylor the the focus to actually treating the cancer so any man with a pardon all the lingo but gleason score seven or higher a great group to or higher prostate cancer and You know somebody with what i would consider. Intermediate risk parameters really should be encouraged to treat intermediate responders or higher should really be encouraged to focus on treating the prostate cancer. Especially if they have a life expectancy of more than ten to fifteen years and that's an important topic to mention is that because prostate cancer can present very advanced stages or ages. Life expectancy is a consideration to in part of the discussion because if a man is in his eighty s and has competing Medical problems sometimes even with significant prostate cancer. We may not treat that cancer because our goal is to do no harm. You mentioned the gleason grade Just for the listeners. And the view is. Can you explain a little bit what that is. Gleason grading is a pathologic grading system. That really looks at the actual cell structure of the cancer under a microscope in the look at the cell structures determine the aggressiveness of the cancer. So the gleason grading system starts from six or three three equals six to five. Plus five equals ten on the extreme advanced presentation form so They've tried to shift away from this gleason pattern to what they call a great groups. Great group one through five and simply for the fact that when men here a gleason six cancer to them they hear six out of ten and they get very concerned that the cancer is beyond five notes to them. It sounds more advanced. So we've changed the nomenclature over the years to accommodate for the fact that gleason six prostate cancer is actually a very slow growing cancer and very early detected non-aggressive other times we think for example patients should seek a second opinion. I think oftentimes when you use the basic minimum to make a diagnosis in stage patient I think that's that is all that's required for most providers. I think for patients who want more information to ensure that they are accurately staged and accurately diagnosed. I think a second opinion at center of excellence is important because there are various things we can offer such as a second opinion. Review of the pathology slides. You'd be surprised. How often pathologist will disagree looking under a microscope looking at the same exact cell and tissue and they may disagree about the the grading of the cancer so gleason grading can be somewhat subjective. And it's based on that physicians experience and opinions. So i think mayo clinic. Of course we have very experienced with Most of the day they spend looking at prostate cancer so they really become specifically interested also experts on prostate cancer so they can be better qualified to make some of those calls when when there is a kind of a a know a subjective situation the other reason why people come for second opinions to a prostate cancer specialist is also to ensure that there are no other tests that could be run that may improve the staging of the cancer so one example of staging imaging. That is really helped over the years. Mri surprised to help patients who are diagnosed with prostate cancer. Oftentimes.

prostate cancer cancer gleason mayo clinic center of excellence taylor
"prostate cancer" Discussed on Mayo Clinic Q&A

Mayo Clinic Q&A

01:50 min | 9 months ago

"prostate cancer" Discussed on Mayo Clinic Q&A

"And that's a metric that most organization use to determine a prostate cancer aggressiveness in prostate cancer. even some of the ages still has nearly one hundred percent five year survival and that's different than the perspective of someone having pancreatic cancer brain cancer where the five year survival Not even fifteen percent time. So you know. I do counsel patients of based on that and tell them to put things in perspective. I encourage all my patients to make long-term plans still into the positive outlook because the dynamic is also the landscape of prostate cancer. Treatment is also being. it's a dynamic process. A one of the things that you mentioned. That was about the stage of diagnosis. Can you just mentioned Described trust to pack. What do you mean by the stage. So the stage of the cancer is the extent of the cancer within the prostate itself so when the cancer is localized to the prostate. We usually say that's oregon confined or stage two when it's a stage three cancer. It simply means that the cancer has gone beyond the capsule or the surface of the prostate. And so that means the Cancers tumors actually penetrated the surface of the prostate in gone beyond its out a nearby structures Outside of the prostate wall stage four prostate cancer means that the cancer has grown into a lymph node or has grown far away from the prostate distant until liver surrounding organs Bones so that would make it a stage four cancer. I see and then obviously i'm assuming depending on the stage. The treatments vary. Can you talk to us a little bit about the treatments that patients can expect when we say localized cancer were simply focused on cancer. That has not left. The prostate has not penetrated the surface of the prostate has not gone into the bones or lymph.

brain cancer prostate cancer. oregon
"prostate cancer" Discussed on On Point with Tom Ashbrook | Podcasts

On Point with Tom Ashbrook | Podcasts

09:36 min | 10 months ago

"prostate cancer" Discussed on On Point with Tom Ashbrook | Podcasts

"This hour we're talking about prostate cancer why we don't talk about it because of issues like incontinence, impotence, men's private parts, and so forth I'm joined by Boston Globe Mark Shanahan who is out with a new podcast Mr Eighty percent, which tells the very personal story about his own prostate cancer and a warning again to listeners, we are talking a very frankly about this disease about sexual function and so on and so forth, and so this might not be suitable for younger listeners. We just want to put that warning out there. mark I want to talk a little bit about how this diagnosis it didn't just affect you affected your loved ones too. So your audio, your daughter Julia was in junior high when you were first diagnosed. So I want to hear a little bit of the two of you talking in episode one of Mr Eighty percent. I think I just took it to like. Like he actually died I would basically lose my best friend. This is my daughter Julia she's in college. Now they say like we're not your best friend like where your parents by. Having. Cancer means you get a preview of what your kid might say at your funeral. You're the funniest person I've ever met I. Think one of the most supportive and hardworking people I've ever met and. I also think you one of the most intense people I've ever met and you have a very impressive career, and so I always like looked up to that and by impressive you mean I have talked to Bj. Novak. You took me to Taylor concert. She gave me her bracelet, right? So. So that's a cut from Mr Eighty percent I'm here with Mr, with Shanahan and mark that's really touching moment. But say a little more about that because you make this, you spend a lot of time in this podcast talking about. The effect that this has on your entire family, and by the way the way your wife stepped up in heroic ways and supported you and this is a huge theme about in this story. It's true Anthony that You know you just can't anticipate something like this and and again it's the nature of this disease that you know. This was something that as my surgeon says, at some point in the podcast, you know when you're when you're treating. Prostate cancer patient, you're really treating the couple. And So Michelle had a heavy lift Michelle, your wife correct. I should say right Michelle. My Wife. And she was Extraordinary and But so it's a learning process. For she and then in terms of our children. You well, I Beckett we would like to get back into the podcast but your son as fifty s fifteen year old boy now and You know we wanted him to say, well, we're going to have to talk about our penises and that was. He he just wasn't willing to go there. So again, it's it is. You know we say in the podcast that you get the cancer but everybody's life changes and you know I I don't think that unless you go through something like this, you can really appreciate what that means but I. Certainly do i WanNa talk a little bit about Get get you to talk a little bit about the course of treatment that you opted to follow. So so walk us through first of all the options that you had to consider. When you were first diagnosed well. So we want to also say that because prostate cancer. So slow growing and because many men who are diagnosed are much older I think that people should think very very carefully before embarking on any treatment that there is something called active surveillance, which means we watch it we pay attention to it. And but but. For Myself I was young I had two kids. I had forty years may be to live and. I had a gleason score, which is a score after they give you your biopsy and take a look at what's happening they grade basically of the severity of the intensity of your cancer in mind was seven. Out of ten that's considered to be intermediate I guess you know the options for me were to watch it to have surgery. Or to a radiate my prostate and. In, the end there have been enormous advances in the treatment of prostate cancer over just thirty years. If I had gotten prostate cancer fifty years ago. I. would be rough rough rough. And not just for me every man who had a prostatectomy which is surgical procedure to remove your prostate. before nine, hundred, eighty, two, left the hospital impotent every single Guy which is just incredible to me because nineteen eighty two is not that long ago. Right, it is incredible. So you went for the surgery but I did but that wasn't the end of your ordeal surgery. It turns out we learned didn't get all the cancer. So you had to go back and sign up for pretty radical course of hormone therapy, and this is really the most excruciating part of your journey to read into here about you describe it essentially as a kind of. Chemical. Castration. Well. Indeed and I don't just describe it that way. That's in fact what it is It removes the testosterone from your body and the reason that we do that is because it's the thing that feeds the cancer prostate cancer. Grows Thanks to to Saas thrown. So if you removed from your body to cells cancer cells week in some cases they die and then when they're at their weakest blast them with radiation. The problem is that when you take a testosterone out of a man's body it is a as you say excruciating I became a different person. ahead you know the the euphemism is mood swings. I didn't have mood swings had a I had tantrums and I will say that I was on the phone this morning, the guy who listened to the first three episodes of the podcast and. He. said, he'd never talked to anybody about his course blueprint and he was arrested he actually got arrested. Because a parking garage. because. He could he he got completely out of control. So it's scary. And and you know now as I sit here. There's you know at this surgery if if the prostate cancer should return, there is no surgery there is no radiation. Those are no longer alternatives. and. The prospect of more loop ron or any kind of hormone therapy is really terrifying mark. You're honest in this podcast in and you tell a story in there and we heard from your daughter Julia just about how difficult this became when you were on this loop Ron Therapy and you tell the story of her eighth Grade Graduation and where you pretty much. Fall apart and and She loses this moment to be photographed in her right of passage. It's a it's a very, very sad story, but I'm just wondering what it was like for you to make that decision to go public with that to hear your family and friends describe. What an unbearable person you became. Well. You know. Here's the thing I really don't have a lot of. You know. Again it's a good story and I'm interested I'm interested in A. After a drinker to these are the stories that I tell and So when somebody at the globe said, you know you got an idea for a podcast I said you bet I do. But I in terms of like. How others will view me and? That sort of thing. I I really don't care. It doesn't that doesn't concern me what's really weird also is that. I didn't do the podcast right the story really yet of any. Sense of. Its crusade that I'm on at all however now that it's out there and emails that I'm getting in on the phone calls and the and the feedback, it's it really is very gratifying. To think that there are guys who were like me. But have no outlet to and no desire to they won't talk about it but they WanNa talk about me. Mark, I want to bring in Dr Mark pomerantz. He's an oncologist. He's one of your doctors through this ordeal and he joins us from the Dana Farber Cancer Institute in Boston Dr Pomeranz Welcome to on point. Thanks for joining us. Oh..

prostate cancer Cancer Mark Shanahan Julia Mr Eighty Dana Farber Cancer Institute mark Michelle testosterone Mark Boston Ron Therapy Dr Mark pomerantz Bj Novak Taylor Anthony
"prostate cancer" Discussed on Clark Howard Show

Clark Howard Show

04:46 min | 11 months ago

"prostate cancer" Discussed on Clark Howard Show

"Where my cancer has not thank goodness grown at all I've never had to have any treatment I just am monitored. On. A regular set schedule. So, there's plenty of time if my cancer suddenly decided to get mean to deal with it but as part of the whole process. My doctor told me that I needed to improve my eating habits and lose weight. So since twelve years ago I've lost fifty pounds five zero pounds. And I never perceived myself as being. Fat. And I don't think anybody who knew me would consider that but they could see carrying extra weight. And I did it gradually over time With controlling how many calories consumed per day and taking the world's worst diet And gradually steadily improving. Because one of the factors with Nachos, prostate cancer, but other illnesses is carrying too much weight. And also eating nothing but the wrong things now I still eat a lot of the wrong things but you know I the right things to. And I used to be allergic to any kind of green except money. So any vegetables were green. They just weren't part of my life. really any vegetables at all put? I've made that change over time and. It's probably part of why I've been able to manage disease. Instead of having to have. An operation you know surgery or having radiation or different kinds of cancer treatments that may be required someday, but I've been able to. Make a difference almost certainly with the behavioral things I've always been an exercise maniac. But adding into at the loss of weight and improving what I eat is considered to be very important. Well. Each year in September. The. Prostate Cancer Foundation has a campaign to try to get guys to improve how they eat. But thing. Is that there's no reason you couldn't. Improve how you eat even if you're not a guy, I mean all of us. are in a position where we can probably eat a little better. Unless we're one of those vegans and the campaigns called, eat it to beat it. We have all the information for you Clark Dot Com.

Prostate Cancer Foundation Nachos
"prostate cancer" Discussed on The Naked Scientists

The Naked Scientists

04:37 min | 1 year ago

"prostate cancer" Discussed on The Naked Scientists

"Entire clinical team including the pathologist radiologists surgeons and nurses them meet to discuss each patient and the best way to manage their case. It depends on the biopsy type because if it is transparently biopsy we take more samples so that take long to expand if it is translated told standard by up say it usually take ten days and then be discussed the case in multi disciplinary team meeting. And we see the patient and gave that assaults and stage. What do you say to the patients? Or what information can you impart to them? And what's the next step so in duracell clinic? We will have the information about the biopsy yourself better. It is a cancer or note if it is a cancer what grade of the cancer and we would have discussed what treatment option is available for patients so when we see the patient be will discuss the findings of the biopsy say advance stories a locally advanced or early prostate cancer and we discussed the treatment options with the patient. We can now worker with quite good accuracy. Where the likely prognosis meeting to see the outcome is with or without treatment. And that's what we use together with the patient to work out what to do next. The first thing to know is that there is absolutely no evidence that rushing through a diagnosis of prostate. Cancer has any impact and survival. So it doesn't really matter how long it takes. The key thing is that he's done well in general terms from the minute somebody presents to say the hospital for investigations to get Anne Marie. Scan to be seen to have a biopsy and get a diagnosis. We try to do that within two or three weeks and then we can make decisions about what to do next. Some people listening to this may be wondering why it is that we have screening programs for certain diseases. But we don't have one for this given that you've said that eighty percent of men aged eighty may well have prostate cancer which argues perhaps would be worth looking for. It's it's therefore very common condition. Why is there no screening program for prostate cancer so the problem screening in prostate cancer is not the fact that it isn't save lives because he does the problem as that he picks up a lot of disease which is treatment and that over diagnosis can also lead over treatment because of poor understanding of the natural history of disease sort of instinct treat rather than monitor and if you look at the statistics as well is very hard to justify so for example in prostate cancer terms the lifetime risk of developing prostate? Cancer is nearly ten times risk of dying of it. You have to find an awful lot of men to save a single life but problem with screening is that its tended to rely on a single test at a single point in time and the test is in good. Psa Like I said is a nice test but it's just not good enough and so a lot of our work. A lot of work of others is actually trying to do two things. Define what is the right time point to pick it up and secondly trying to get a better test to pick it up. Are you having any luck? Yes there are actually a number of tests out there which already better than the pse. The problem is that the cost more as well. We are very interested in actually binding better tests with a much more evolving way of looking at this because the way we see it is that each man's risk changes with time and how put together as what we are exploring at the moment but. I do think we have the tools to be able to better detect Kansas which are going to spread for example and actually intervene enough and would that translate into a saving? And that's exactly what the Holy Grail is. Because in the end of the day screening low early detection for cancer actually has converse side which is not picking up things that you don't want to pick up and that in itself is a goal which I think is worth doing because if you can reduce the number of people you're going to be looking for something that means you can get your resources redirected to finding the ones which are important. Most of the time we're so fixated on finding and more and more cancers that's what we WANNA do. We forget about the fact that there's a lot of people who are investigated who turn out not to have chances And that is actually a big burden for the health economy for the individual and ultimately if you do diagnose something which too early you you do. Condemn someone to be monitored for something which didn't know about. It's a little bit lake saying if we started do genetic testing birth everyone what it tells us a potential. You might get something rather than you will get something and then you're going to end up stressed body for all your life and.

Cancer Anne Marie duracell clinic Kansas
"prostate cancer" Discussed on The Naked Scientists

The Naked Scientists

03:59 min | 1 year ago

"prostate cancer" Discussed on The Naked Scientists

"Progress. Them is a urologist specializing in this topic of the University of Cambridge. Everyone is at risk and they used to say that. If you live to eighty eight percent of men will get prostate cancer. And that's probably true having said that certain groups at higher risk so particularly men of African descent a high risk or if you've inherited certain gene mutations in particular bracket mutation but that's only about one percent or so and we still don't quite understand why some men develop prostate cancer more rapidly than others do but what we do know is that when a man presents with prostate cancer. The older the are the more likely to have more advanced disease. So really prostate. Cancer is a disease that evolve over time and real challenge. Here is to not over diagnosed cancer. Which is early but at the same time. Not Picking up when it's too late and that's what we're going to explore as we go through the program but first let's back up very slightly. What is this gland that we're discussing? Well the prostates found only in men. It's it's below the bladder surrounding the re throw the tube that drains urine normally the prostates about the size of a small sat suma and his job is to produce many of the components of seminal fluid gets older his prostate naturally enlarges which can obstruct the flow of urine an although this enlargement usually has nothing to do with the development of cancer. It's nevertheless often. The trigger that sends a person to see their GP who then investigates further my name. As spinney that anger Naiad I'm McMillan lateness for urology and prostate cancer. Specialists nurse add in books they usually they usually symptoms are caused by the enlargement of the prostate. All men have their prostate getting enlarge from the forty years of age and when it gets bigger it causes obstruction to the water pipe because the prostate sits under bladder and the water pipe go through it and when it gets enlarge squeezes the water pipe which causes a restriction to pass urine which lead to the symptoms like getting up at night or frequency or urgency like that the enlargement of the prostate is majority of the time due to the nine enlargement but sometimes advanced prostate. Cancer can cause some of those symptoms as well which is wife someone has them. It's important that they should get checked. Yes are there any other symptoms? Because we'VE DWELLED ON URINARY SYMPTOMS. Are there any other ways? In which prostate cancer could present in the first instance that the person might not think anything to do with the system. The other symptoms is usually borne pain. And that's majority of the time and it is an advanced prostate cancer. Usually patients get born pain. And they're put it into their stretched all done something physical to their back core things like that so when the person goes to the GP with these symptoms what sorts of things would they expect the GP to have done or checked or have put in place before they would send them to you so usually if patient presented to the GP the GP should take the history especially the universe symptoms when it started. If it was a long-term udon array symptoms and getting worse it's usually because of the enlargement of the prostate but if it was sort of happened in short period of time could be usually infection and so it is important that Jay paychecks urine sample and then if there is no infection. Jp should do the blood test prostate specific antigen and usually the GP will explain what is the prostate specific antigen. What can make it go high and things like that. So that's what I'm expecting the GP to explain to the patient before they make that Ruffalo so significant emphasis placed on the PSA test. But what actually is prostate specific antigen.

prostate cancer University of Cambridge suma Ruffalo Jp Jay spinney McMillan
"prostate cancer" Discussed on The Naked Scientists

The Naked Scientists

06:14 min | 1 year ago

"prostate cancer" Discussed on The Naked Scientists

"Sorry to Button Katie here from the naked scientists. Did you know we make other naked to the fraction of all humanity? Who has actually gotten a chance to see their own? Brain is very tiny and you are welcomed to that club. So if you enjoy musing over the mind reflecting on thought ought frankly you feel bamboozled by the brain checkout naked neuroscience blow? My face hurts now. So we don't go down into the creepy seller and turn the light on exactly access the full archive by a naked scientists dot com slash neuroscience subscribed to naked neuroscience. Wherever you get your podcast on the way new powers for the UK to regulate social media and our in depth look into prostate cancer now from very high altitudes to very high energies. Scientists have unlocked the next stage in the cutting edge that is experimental physics. This is an to facilities like the large Hadron collider where beams of tiny particles race around nearly the speed of light and then smashed into each other to reveal what they're made of the results shed light on the fundamental nature of the universe. The experiment is next step. Though is to up the ante using mules. These are essentially heavy electrons. Which can be collided at even higher energies but these have been very hard to make into a focused beam now. An international collaboration has managed to create that beam in what they call them you on is Asian cooling experiment or mice. I got some concise mice advice from research leader Chris Rogers. We've demonstrated a technique whereby we can take him of particles called Megan's we can squeeze them right down and accelerate them to really high energies because of the unique properties of millions. We can actually explore physics. Which is even beyond the scale which is available in the large Hadron Collider. Wow this is real futuristic. Yeah right that said An. No-one's developed a technique like this before which can really be used to handle moonbeams what exactly is immune to start with so it is like a really heavy electron have meals going through you pretty much. Every second of every day which come from cosmic rays. I've immune to me right now. That's pretty much right. What do they look like? Just like electrons except for a couple of special properties one. Is there much heavier than electrons. Almost two hundred times heavier than electrons and the other one is that they decay radioactively so they only live to millions of a second. That's bizarre. How'd you even deal with them? We have a special trick. Us leave if you accelerate particles to really high speeds as the particles get closer and closer to the speed of light. They live longer and longer. His Einstein's time dilation phenomenon. How do you make them you on your lap? We take a beam of protons accelerate those protons and then bash them into a target all sorts of other particles. Come out and some of these particles immunes and how have you been trying to deal with them in this particular experiment because the first time you've managed to get them into a beam correct? We've had millions in a beam before but we've never really managed to prepare a beam so that it would be suitable to accelerate them much more like a laser beam. If you like. We passed that meal and beam through absorbing medium and as the mules go through the absorb. They lose energy all of that hot gas slows down as it goes really absorb so then. We need to accelerate that being back up using a conventional. accelerates technique. What's this material? You're filtering them through. Is it something special in strange? We use I. The liquid hydrogen cooled down to a few tens of Kelvin always lithium metal with hydrogen embedded into the metal. Those are strange and weird. They're pretty cool. Bits of kit which we used to do it. Why does win? The meal ones go through the absorb they not the electrons of the atoms and when we not the electrons off the millions lose energy. That's what's called ionization. And that's why the techniques called on is Asian cooling. Now there's another thing which happens. They bashed into the center of the nucleus. And they scatter off flying off in all sorts of different durations. Now we don't want that so we have to pick special materials where the nucleus of the atom is as smooth as it possibly can be. Hydrogen has the smallest nucleus of any material and lithium has a pretty small nucleus as well. Is that why? It's taken so long to figure this out because you're trying to get materials with small enough nuclear nuclei nucleus Ukiah Nuclei. It's not just the material which we have to consider. We have to combine that with a possibly accelerator. Lattice and combining those two different things into one experiment was really tricky. What did it feel like when you finally managed it for the first time it was pretty cool? In fact we only cooled the beam by about ten percent of the full cooling channel which you would need a real meal collide facility but that was pretty cool. I'm what does this mean for physics? Is there really exciting? Science coming up that could potentially use. Mu On beams. The aim of our experiment then is to take this technique and then put it into a single immune collided where we collide beams of meals together. Mueller light is a really exciting because they let us reach much higher energies than are available using even existing facilities like large Hadron collider sern a large Hadron collider upgrade. It would be a large meal and Kaleida Large Mu on collider. That's cool should be. We'll have to wait and see what happens. When they try it Chris Russo from the Brotherhood appleton laboratory discussing the experiment. They call mice and which was published in the journal Nature. We're heading back in time because Adam Murphy's been looking at some cracking cutting edge science using eggshells to take a dinosaurs temperature Jurassic. Park is.

UK Katie Chris Russo Chris Rogers Brotherhood appleton laborator Megan Kelvin Adam Murphy Mueller Einstein
"prostate cancer" Discussed on The Peter Attia Drive

The Peter Attia Drive

03:28 min | 1 year ago

"prostate cancer" Discussed on The Peter Attia Drive

"The bloodstream. So what can make the PSA rise besides just having getting older and having a larger prostate. Well if you get an infection in your prostate so think about that like you got your city. You have her sewer network and there's an earthquake all all the pipes are rat a little bit and they all are extra leaky. And that's what an infection is is not a infections in the prostate or either all or none really they're not focal so the whole prostate gets more leaky in the. PSA number can go way up the other way to think about it as if you have cancer and the the analogy would be lulled. There's there's a city block that has the pipes pipes you know the sewer systems clogged. There's more backflow into the bloodstream. And that's how I pick it up. That's not really how it happens. But that's a good way for patients to think about it. So what is a normal. PSA well a normal PSA is age adjusted so normal PSA for a forty year old is around point five two point six nanograms per aml for fifty year old normal meaning. This is the median for all the population for a fifty year old. It's one and so it kind of goes up stepwise by by decade so there are eight adjustments that we do for the PSA number now what are PSA numbers that tell you you don't have a cancer there's no. PSA number that that is one hundred percent no cancer but there is a proportional rise in cancer detection with rising PSA numbers so originally the cutoff set a PSA of four. We do you know we think about things more based on the individual scenario so if you're a younger person and if your PSA more than two point five that usually considered to be abnormal and may want you may need further work. You don't need a biopsy right away these days in my opinion but you need further workup. So depends on the age of the patient and depends on how also their prostates announce how many guys will go and when they get their PSA check. There's another thing that gets checked. Checked called the free. PSA and then a number is reported. which is the percentage free which is obviously that if their? PSA is three and they're free PSA is one the percent free free is reported thirty three percent. What does that mean? These are different ways for urologist. Try to fine tune this prostate specific antigen test to make it more a cancer specific test so again. PSA goes up when you have an every man has it's not cancer specific so so percent free. PSA was the first way that urologist began to look at what. What's the chance that A? PSA of four is coming from cancer sir versus a PS four coming from just benign overgrowth. So remember there's a lot of factors in play one would be if you had a man who's prostate volume was eighty grams that big and his. PSA was four well. That's of low ratio that's something called. PSA density how much PSA's made per gram of tissue issue. So you'd say well that guy. It's very low chance that he has a cancer that guy would also have a high percent free free. PSA So percent free PSA is another way to just look at what how much of the PSA's produced from benign cells versus cancerous cells. So if two guys have A. Psa of four and one has a free of one. He's twenty five percent free and the other guy has a free of three which is seventy five percent free. What's the different physiologically in those situations?.

"prostate cancer" Discussed on The Peter Attia Drive

The Peter Attia Drive

02:08 min | 2 years ago

"prostate cancer" Discussed on The Peter Attia Drive

"He's at at the hutch and Seattle, and he published a paper, and they look. At the germ lines of men with metastatic castrate resistance with the most end stage prostate cancer, and what they showed was that. In contrast to the general population of men that mutations in these different DNA repair, pathways or significantly enriched and individuals who had metastatic prostate cancer. So about eleven to twelve percent of men with metastatic, castrate resistant prostate cancer mutations. Particularly Brock to Braca one ATM RAD fifty one these different pathways that are involved in DNA damage repair. If you look in the tumors of men with metastatic, castrate resistant prostate cancer, it depending on where you look over one third of the tumors. The cells will have mutations in these pathways, which makes them incredibly sensitive to park in addition. So that's a huge game changer. The other thing that people now look at his kind of the total genome scorer the alterations in the genome of the individual cancer cells will that make them more sensitive to immunotherapy? Fear. Not that's more coming online. But the idea that there are things in the semantic DNA of the tumor cells, and in the germline of individuals that you can use to screen for not only, you know, prostate of breast pancreas excetera that's a huge game changer. And then as we touched on earlier, those are not just prognostic biomarkers, but their predictive of drug response, which is pretty amazing. And then I think allies test the version two point. Oh, or the beta version of it which has a lot of these built in biomarkers at predict responsive drugs that now are being tested in clinical trials with with the idea that let's test the ability to predict response, it's pretty mazing. Stop actually. So obviously, you specialize in prostate cancer the field of urologists so much bigger than that. Right. We haven't even talked about renal cancer bladder cancer, and to do so would only be to do it an injustice. You know, given that we've been talking for a little while. And I know you've got a hard stop here in about twenty minutes. I wanna talk a little bit about benign stuff. So I'll tell you personal maybe.

prostate cancer renal cancer DNA damage Seattle Brock twelve percent twenty minutes
"prostate cancer" Discussed on The Peter Attia Drive

The Peter Attia Drive

04:21 min | 2 years ago

"prostate cancer" Discussed on The Peter Attia Drive

"Is converted via an enzyme called five after reduc days into a very similar molecule called dihydrotestosterone abbreviated DAT. Dat is actually any slightly more potent steroid and in men who fifty times more potent. Yeah. So the in men who are susceptible to baldness DHT, drives that process D H T also probably plays a role in the enlargement of the prostate is correct. Most of the five for duck days enzymes in the prostate. So yes, reducing Anderson's in the prostate by reducing effectively. Reducing DHT production reduces the size of the prostate. So a lot of guys take medication to reduce DHT either to reduce prostate volume size of something called benign prostatic, hypertrophy or to re minimize hair loss, and it's usually the exact same drug given it slightly different doses. And sometimes even come up with different names for the same drug. So proc-. Car is financed. Rated five milligrams. And I think pro-peace says the one milligram nets. Right. Okay. Now, I remember many years ago, and I don't I'm sure this has been revised one hundred times, but maybe ten years ago, maybe less, but a paper came out that said look in guys who have suppressed DAT levels when they get prostate cancer. They're more high-grade is at my remembering that correctly. And there's been definitely case reports of that. It's hard to really study that over I gotta yeah. So what is the current thinking on five algebra dictation habituation, and that relationship to prostate cancer? Well, there's was a very large randomized trial to see if you could take that medication with the idea that if you reduced the relative amount of Andhra Jensen the prostate by preventing the production of his potent androgen DAT. Could you reduce the risk of prostate cancer in those men and the answer was if you took that medicine that reduced potent Anderson? Hugh could. So there was a oatmeal study. This was in men starting out who did not have cancer. That's right. So it was called the prostate cancer prevention trial, and it was over seven years at the trial is conducted in Thompson was the PI on the trials of big study. It did reduce the chance at a man would develop prostate cancer overall, you know, reasonable amount of time. But one of the problems was that there was increased detection of more aggressive cancers in the men who are taking the finance. Right. And so then the question was, well, what is that? From is it inducing, a more high grade cancer, you know, and whether or not that's true or not as or is it selecting for it because any cancer that comes out of a low DHT environment. Well, yes. So I personally think that what you were just saying as is true. So yes, and there's case reports that people with low testosterone, or for example, people with low PSA's because PSA is only made when there's testosterone around, for example. That those individuals have more aggressive cancers. Now, this is what I've been focusing on in my lab for like the last four or five years now. And so one of the cool things we did in this collaboration with this company genome DX in this great, scientists alight of an she Oni was to look at the biology of prostate cancer, how grass if they were and compare the gresh Innis of the prostate cancer with the Anderson output of the tumor another nuanced way to normalize things a bit. Yep. And so we had this ipod uscis that the tumors that had the most amped up Anderson, signaling the most Anders output because prostate cancers and ginger tumor that they would be the most aggressive, and I say that way 'cause you know, the answer stieg's act posit the tumors with the lowest Anderton output or the are the most aggressive tumors. So it's somewhat relates to PSA, but not entire. Fairly like there's not a is on a true, you know, linear correlation. So the high Anders output tumors. They can be aggressive, but they are not as aggressive as Alterra low once's by modal distribution. And this is a good way to segue. Talking about these molecular tests because this is a commercially available test from genome DX might tell a funny story about ally. Before we go down there. Sure, I've told this story before but now we get to put a name to it..

prostate cancer Anderson dihydrotestosterone Andhra Jensen testosterone Anders gresh Innis Hugh Thompson stieg seven years five years ten years
"prostate cancer" Discussed on The Peter Attia Drive

The Peter Attia Drive

03:20 min | 2 years ago

"prostate cancer" Discussed on The Peter Attia Drive

"I'm sure have different versions. But even from a screening standpoint that they could be you'd have one tool that is so good in both yet. There is fortuitous. Yeah, they're good tools. And then so after if there's an abnormality in the P H I R four K score. Then I moved to an MRI. And then there's been good day. Can you just because I mean, we talk we geek out on this stuff because I'm super nerdy about what type of MRI to do for what thing, but for a patient listening to this Ted who's going to go to their doctor, and whose doctor is hopefully cooperative enough. What do you recommend because not all Emmys doing the trick here? Yeah. I mean on paper what you want a multi parametric prostate MRI, the most important phase the most important parameter in the multi parametric MRI is actually the diffusion weighted imaging which is the most operators dependent. So it really requires a skilled technician and escape. Killed interpreter. Radiologist to look at those DWI images, that's the most important one. So we do get patients contrast. But people showing you can get a lot of value out of just non contrast DWI based the one we use. No contrast, but it's their DWI's exceptional. I've sent you the images I think if they're Schaefer approved I'm happy. They're very good. Yeah. T one t two DWI an multiplayer MR is if you're listening to that. And if you and if your doctor refuses that I think those are the kinds of things that make me think you need another doctor because at this point and look your insurance might not cover. You may have to foot the Bill for that. And that's that's horrible. Well, wouldn't cover that? That was true. But there's recently reported a large multinational prospective clinical trial, looking at the utility of Mariah used for screening for prostate cancer. And the study was half the men got an MRI of their suspicious lesion. They got that lesion biopsy. And they increase detection of high grade cancer reduce it over. Detection of low grade prostate cancer. So it was a quote, unquote, positive study. We haven't had problems in the mid west Illinois getting 'em is approved. But that randomized trial based out of reported out of the UK that really has changed a lot about what companies are approving for Moore is for screening so rate to here. So so if somebody has an MRI if there's an Adra malady on the MRI, I'll recommend a biopsy. Now, there's a lot of data that says you shouldn't just sample the suspicious lesion that you should do the suspicious lesion plus doing a Sexton. Bob Sierra, kind of what I tell patients is right left top middle bottom that adds value. Not just in the detection of cancer. But if someone is gonna move to surgery, for example, and I don't do a biopsy in ninety year old guy. Even if they have an abnormal Marai, do it. If I think that person's gonna live a long long enough to benefit from treatment in those scenarios. I do those systematic by because I want to know exactly where the extent of the cancer and one of the problems of them arise it it doesn't. Actually, see the true boundaries are true. Borders of the tumors within the prostate, very well. So they're often especially the DWI because it's not really an anatomic. Yes. The way a t one way to images traffic. So if you take if you take the lesion on T to for example, it often under sizes the tumor by between five and ten millimeters. So pretty significant for prostate, which is generally pretty small. So so I do those to get a better roadmap..

prostate cancer Bob Sierra technician Ted Schaefer Adra west Illinois UK Mariah Moore ninety year four K
"prostate cancer" Discussed on The Peter Attia Drive

The Peter Attia Drive

02:02 min | 2 years ago

"prostate cancer" Discussed on The Peter Attia Drive

"On every cancer. And there's one other one other oh, the CDC is the fifth body to weigh in. And we show them. Here are the recommendations from all five of these for every cancer. And I remember when that shift changed to for prostate cancer. There's no more recommendation while the recommendation is talk about it with your doctor pass the buck besides the I think the American kademi of family practitioners, and they don't recommend PSA screening still. I'm not sure why. But you know, that's a different discussion. But the bottom line is that almost all the guidelines now say it's a shared decision making process, which I think makes perfect sense. That's how I view mod modern medicine. Yeah. It does it. In theory, makes great sense. What I worry about Ted is theirs. A bunch of patients they get caught. They don't have doctors like you or me who are willing to be able to have had the luxury of the time and the ability to educate themselves to do that. Because I still see a lot of patients that show up and they're not getting screened because their doctors basically saying, well, obviously, this is quote, unquote. Controversial, you know, I sort of remember hearing that we shouldn't have been screening. So we're not gonna do it. And that's that's sort of my fear with these things. Well, I think I think shared decision making it require also. So then to me conceptually, it makes a lot of sense in reality. What does that actually mean? Well, that's the next question. That's the next unknown. Right as well house. Our shared decision making process, how does it occur? And when a patient sees you that's different than when a patient sees an average internist, let's say, and it's different. When a patient doesn't see any doctor. So, you know, the idea that there's the bus that rolls up that just does your bloodwork and send it back in the mail. That's terrible. I mean, I did that when I was a resin they pay me fifty bucks. Go man the bus and do that. That's not really doing that patient, those individual men any, you know, any they're not helping those people because you don't know their whole health history. You know, and all that. So I experienced that. And you know, I got into it with Otis Brawley about screening, and you know, he raised that point in. It's valid. I did that when I was rather than because I was told to do it..

Otis Brawley prostate cancer CDC Ted
"prostate cancer" Discussed on The Peter Attia Drive

The Peter Attia Drive

03:05 min | 2 years ago

"prostate cancer" Discussed on The Peter Attia Drive

"Forty percent of men coming in with prostate cancer metastatic at the time by two thousand it was four percent. Now, the skeptic is going to say this is such a controversial topic. So it's so good that we're. Doing this the skeptical say, well, that's just lead time bias. I mean, all you did was catch a bunch of men earlier. So you have a much bigger funnel. Right. Right. So by the way, the same controversy exists on mammography. So I can't wait to actually sit down with Ted Schafer quivalent of breast cancer at some point. Because I realized that an episode like this is probably a little bit more geared towards male listeners or probably the female listeners who have males houses or people that care about going through this. But it's interesting to watch the rise of mammography and the rise of PSA go through this parallel thing and Kohanovsky though to a slightly lesser extent that really being the big three mass employed screening while it's and it's been written about Al Peter you've written about this. So Peter Albertson is a nother Hopkins alum, he's Charon Connecticut, and he's an anti screener effectively for prostate cancer. And he wrote about this, and he showed that if you just look at incidents of metastatic prostate cancer incidence of metastatic, breast cancer. There's no change with implementation of. Mammography? There's a huge drop in the incidence of medicine prostate cancer with implementation. So why is he anti screener? Well, he just he was historically. He wrote this paper and showed that there is a huge difference. So now with screening you have increased detection, and what we've learned is unlike let's say pancreatic cancer where most of the time if if you picked it up early if you did nothing it, you would die not everybody who has prostate cancer has a lethal variation of it. And so initially we developed a biomarker to pick up all prostate cancers that was the PSA blood test. We pick them up we treated them, we reduced deaths. We also over treated people people who had a cancer that would never have been lethal in their lifetime. That's the dying with the dying from. And this is something you and I used to talk about nearly twenty years. I remember sitting in the cafeteria because you know, even though you know, you. We were still interns, and basically two knuckleheads you knew you were going to do this. And you were always head and shoulders above everybody else in terms, which when I said, I remember asking like, I don't get it. Like, why do some guys get prostate cancer? And it seems to be relatively uninteresting like, yeah, they and another guy though at it and they're dead in two years in it's his devastating pancreatic cancer. What is it about the biology of that because it strikes me as more a function of the biology than the environment? You're the host. But but I could be wrong, of course. But I remember talking about the Salahdin and really coming away scratching my head thing. I don't but clue what's going on this disease. I mean, I'm still scratching my head about it. Because that's my whole research program is all about his will what's the molecular biology, lethal prostate cancer? So we'll talk about that in a second. But to circle back to our story. So we diagnosed many men with prostate cancer, we.

prostate cancer prostate cancer metastatic pancreatic cancer cancer Charon Connecticut Ted Schafer Al Peter Kohanovsky Forty percent four percent twenty years two years
"prostate cancer" Discussed on The Peter Attia Drive

The Peter Attia Drive

02:55 min | 2 years ago

"prostate cancer" Discussed on The Peter Attia Drive

"And I don't think I was I don't think could process it what it would have meant. Anyway, if I had asked, but when I was a medical school, and I was doing my PHD I asked. My parents what he died of and he died of prostate cancer. So I was at the NIH I was doing science. I had done some clinical work. I realized what people in DC not in science. But in politics were interested in their interested in cancer biology, and they are interested in prostate cancer. I saw at other people are interested in and I had this very vivid memories of my, you know, my father migrant, my grandfather, having prostate cancer and dying from it. And I decided that that's what I wanted to do. So when I came back to medical school. I knew that I wanted to be to be a prostate cancer biologist and understand the disease. I also knew that I wanted to be a surgeon. And so I didn't to be a medical oncologist. Although that appealed to me a lot, and I'm always flattered when people think of a medical colleges because those guys are smart, they're smart. But I knew I wanted to do something I love working with my hands. So for me, the I. The of being a surgeon. Scientist was just it just made sense. I loved the biology I love, but I still love the idea of not just conceptually deconstructing something and putting it back together. But actually, physically deconstructing something putting it back together. So as a perfect fit for what I wanted to do for the listener to put some things in context at the time that you and I began our residencies. I don't really think there was any debate about what the best urology program was in the United States. I think there is a good race for number two or lots of programs that would have competed to be the second best urology program in the country. But but Johns Hopkins was hands down in a league of its own. And they only take two residents per year. So if there are four hundred or five hundred medical students graduating who want to go into urology only two of them get to go to Hopkins, and you were one of them, which perhaps isn't surprising. Did you wanna go to Hopkins for reasons other than it was the best program? Was there something about the environment? There. There that drew you to it. Yeah. It was a people. It's an amazing place that I think about think about it all the time. So I interviewed there and the chair of the department. The time was is the godfather of my field. He made all the contemporary modern discoveries in prostate cancer. And it was real simple. He looked me in the eyes. And he said, I looked at your CV. I know what you have the ability to do. And I wanna help you get there so pet well selected you as much as you selected Hopkins. I guess you can say that. Yeah. You know, it was a perfect fit because as we've talked about mentorship is just so much of everything. It's everything in life. Really? If you're motivated, and you have drive, it's, you know, even if you're not motivated, you don't have drive you need a good mentor. So for me, I showed up for the interviews. I'd interviewed all over the country..

prostate cancer Johns Hopkins NIH United States Scientist DC
"prostate cancer" Discussed on New Jersey 101.5

New Jersey 101.5

01:45 min | 3 years ago

"prostate cancer" Discussed on New Jersey 101.5

"I had prostate cancer. You know? Listen, I think the hardest part is the mental thing. Really? You know, you go through the wine knew how did it happen to me? But you know, if you're. So hosting you could you know, we're jersey strong. You know, so we could get through anything in my case. I caught it early. You know, we pay all this money and health benefits. Right. So I go like four times a year blood work. And what happened is my say, you know, for years was three point. Oh, then all of a sudden jumped to four point two doctor said to me. Well, that's not too bad. He says anything under ten is pretty normal. But if you wanna do a biopsy, let's do the biopsy. What the hell let's do the biopsy. So I didn't hear from them for like a month after the bye. Everything was okay. Right. I get that phone, call and dot doc. How you doing? Listen wants to come in and talk to me. And I'm like, why worker matter what did you have? I would say cancer, man. You know, what I gotta hit the brake. But I'm glad just remedy is arriving December first of all of the two year. My suggestion. Get back we pay enough in health benefits guys should start in their forties. Never will never smoke. And guess what? I got. Yeah. You gotta do it. You gotta get checked. And what do you do when you real.

prostate cancer two year
"prostate cancer" Discussed on Discovery

Discovery

02:05 min | 4 years ago

"prostate cancer" Discussed on Discovery

"I'm annoyed on and this is the truth about cancer on the bbc world service the series that investigates the most common global cancers and what's being done to tackle them i'm in port of spain the capital of trinidad and tobago in the carribean people are enjoying the food stalls and the music in this park their families all around us and you can really clearly see that some of the people are of african ancestry and others have very clearly of southasian indian ancestry and that's because their ancestors were brought here during colonial times as slaves and indentured labourers and you can really see that mixed heritage in the food busy young men of year serving doubles this is up fried indian bread with chick be curry and fiery sauce another lady over here grilling meats and serving fried plantains now trinidad and tobago has one of the world's highest rates of prostate cancer this is a cancer specific two men so i'm here to find out why that's the case and how doctors are dealing with it prostate cancer right no is the leading cancer in trinidad and tobago it's ahead of breast cancer it accounts for twenty percent of the council's prostate cancer is also the leading cause of death from cancer in trinidad cancer being the second most common cause of death in trinidad led by cardiovascular disease so what is the prostate and how does prostate cancer develop will head into a prostate examined just a moment but to run over the basics the prostate is a small gland in a man's pelvic region it sits immediately beneath the bladder behind the penis in most men the prostate gets bigger as they age but in some individuals cells in the gland develop abnormalities which make them grow out of control and become malignant this is prostate cancer.

trinidad african ancestry prostate cancer bbc port of spain tobago trinidad tobago twenty percent