35 Burst results for "nicotine"

Philadelphia sued over bill limiting flavored tobacco sales

KYW 24 Hour News

01:09 min | 3 d ago

Philadelphia sued over bill limiting flavored tobacco sales

"Officials struck back today at three cigar makers that are suing the city over a bill that limits the sales of flavor. Tobacco products. Okay, whatever you City Hall bureau chief Pat Lowe reports, the officials charged. The suit is a threat to both public health and racial justice. Late last year, City Council banned the sale of candy flavored cigarillos in any establishment that allowed Children inside the cigar makers charge. This was effectively a ban on all sales since few stores are adult on Lee. And they sued on three grounds that the law is preempted by state tobacco regulation that it's vaguely worded and overly broad. These companies ought to be ashamed of themselves. Health Commissioner Tom Farley says. The products are designed to appeal to Children with bright packaging and sweet flavours, alleging the intention is to get them addicted to nicotine. A drug that kills this is like selling Coke, good 19 and corner stores. Doctor Farley says the products particularly target minority youth before the law, they were much more widely available in communities of color. You want to see one concrete Example, why African Americans have higher rates of cancer and heart disease. You have to look any further than these flavored cigarillos. None of the three companies suing the city responded to requests for comment. Pat Lowe became y W NewsRadio

Pat Lowe Doctor Farley City Hall City Council Bureau Chief Commissioner Nicotine LEE
Juul Shelves Plan for Feature That Counts Puffs

WSJ Minute Briefing

00:20 sec | 2 weeks ago

Juul Shelves Plan for Feature That Counts Puffs

"E cigarette maker jewel labs has cancelling development of a feature that some of its employees said could help users reduce their nicotine consumption. The feature allowed consumers to track the number of puffs they took on jewel vaporizer jewel cited budget cuts for the move. We reported exclusively this week the company plans to cut more than half of its staff.

Jewel Labs Nicotine
Vaping linked to risk of COVID-19 in teens, young adults

KNX Morning News with Dick Helton and Vicky Moore

00:31 sec | Last month

Vaping linked to risk of COVID-19 in teens, young adults

"Do you have a teenager in your house who've apes? Well, here's the health warning. First, it was concerns over the nicotine content any cigarettes for teens. Now a new study links the habit to Corona virus. Researchers at Stanford University School of Medicine have discs. Over that teenagers and young adults who've ape face a higher risk of covert 19. Then those who don't the study also shows that those who ve for 5 to 7 times more likely to be infected because of the damage caused to their lungs. It also revealed that lower socioeconomic status was linked to a higher risk of being diagnosed. Lisa Matteo CBS

Lisa Matteo Cbs Stanford University School Of Nicotine
FDA Bans Sale of Puff Bar E-Cigarettes

AP 24 Hour News

00:39 sec | 2 months ago

FDA Bans Sale of Puff Bar E-Cigarettes

"S. Health officials are cracking down on a brand of fruity disposable e cigarettes that were never approved for sale. The Food and Drug Administration has sent a letter to the California company telling them to remove puff bar E cigarettes from the market within 15 business days. Some of the flavors mention were mango, pink, lemonade and strawberry. The agency also sent warning letters to nine other companies that are either selling similarly unauthorized e cigarette or nicotine solution. Is that illegally appeal to Children. Some of them mimic packaging of sweets and cereals like Twinkies and cinnamon toast crunch. I'm surely

Food And Drug Administration Nicotine California
Monocle Reads: Warriors, Witches, Women

Monocle 24: Meet the Writers

05:19 min | 4 months ago

Monocle Reads: Warriors, Witches, Women

"Let's let's talk about this new book of yours which is is fascinating and your goddess has come from really diverse cultures. Tell us about them. Because you've got one from the Shinto religion of Japan you've got got us from Bikini Fussier you've got ancient Greece. Of course tell us a little bit about some of those are tried costner as widely as possible because I think We generally know about the goddess of Ancient Greece and Roman as classic. Go says is but I tried to go with other big little bit deeper went to Mexico and Egypt and Australia and China and kind of eastern Europe I wanted to. I wanted to take in more and more stories. Make more colorful more diverse. I also tried to kind find goddesses who wouldn't necessarily straight wouldn't necessarily even female they'll kind of gender fluid ones in that to Your favorites to write about. I think my absolute favorite who was kind of a new one to me Mami Wata his an African go she's water originally Pantheon of water goddess and. I was really interesting fussy because look she looks fantastic. She's she's half woman. Half Fish is a mermaid character. She loves herself. She's in love with her own reflection. She's beautiful money she brings people money. She's she's kind of happy joyous Goethe's also already. I loved to story in how evolved so she started off as an Oscar award good as but then her story taken through Africa and codified by traders from Europe and then when the slave trade started and thousands and thousands of Africans were taken to America makes it the terrible terrible conditions in the Americas and they took her with them and they worship her made a really specific way of worshipping her through an intense dumps and go them through the tough days in America and in the Americas and gradually she became criticized and became Pau voodoo religion. And it's just that story of. Her story tells the story of people to And how all of this mutates through time it's particularly pertinent telling it from a feminist perspective at this post metoo time. How long is the book been in the works? I mean was me to something that spoke to as you were writing it absolutely. Yeah the informed it that beautiful kind of me to inform the also kind of rising in witchcraft. Catch on the news. That'd be these little groups of young women who were who went to Heck Donald trump not really kind of inspired me and just to this is. It's a new take old stories. These old archetypes for something very modern new and and me too as well. I think a lot of things. That's the story of Cassandra. Who is kind of illustrates the maitre movement beautifully? She was a great Prophet. Who was after? She refused to have sex with somebody and so she was cursed. Older prophecies were true but none of them believed and that really Kinda resonates within me too movement. I mean it's interesting. Isn't it because as women we can be revered as God says or absolutely reviled as witches? Yeah absolutely and I think sometimes some of these stores in one person would be revered as a God s and you know within sentras or even decades. They've been vilified literally demonized and turned into this figure of height because they symbolized an older religion or they symbolize something that historians or writers coming despised so so that their stories are kind of turned around and they yeah they they were even one person could be could represent both of those than yeah. Yeah I'm interested in Shinto. Tell me about your Japanese goddess. Love my Japanese go to. It's I know it was you may. So she was a some nothing good s she's a good of stumps of dawn. Mirth and revelry and she. She's just fun. Some party go almost she but she saved the country because the goddess. I'm Tera it's going into hiding in a cave. And the son of summer had disappeared from the country it needed to be brought back again so I may know. Zoom went outside the cave. She got MIRA and she did dumps and she took clothes off she wasn't wearing any underwear antidepressants on the drum. And and the some good a curious about this she came out the case and then they wrote about the start of the case and she was she was out again in the summer shining again. And I just. I love the kind of lightness that story and the fun. And she's not this serious munificence with with long has his cut flights about the. She's a real person that really resonates. I think absolutely who doesn't want to dance in the sun with no nicotine. Yes exactly that. Wouldn't she really party and an I love the fact that still today kind of drumming groups named for her she. She's inspired the drums in Shinto ceremonies. And I love that. I love her. She's alive three music today. A wonderful

Mira Donald Trump Europe Greece Bikini Fussier Ancient Greece Costner Africa Mami Wata Japan Americas Nicotine Mexico Oscar China Egypt Australia
Creating Implied Nude Photographs

This Week in Photo

12:06 min | 5 months ago

Creating Implied Nude Photographs

"A welcome back to another episode of this week in photo. I'm your host Frederik Van Johnson. Today on the show. I have the distinct pleasure of having a good friend of Mine Mr Grainger. You've seen it on the show before this time. He's joined by somebody. That's more cool than he is. Stephanie Fam- she happens to be a model and several other things that we're going to learn about during this interview. She and Matt collaborated on a project tutorial a training course on implied nude photography. So they're kind of the one two punch in that industry right now. We're GONNA. We're GONNA talk about some of the secrets that that photographers need to know about. In order to be successful in that genre photography and sort of avoid some of the pitfalls that that a lot of people fall into so men's Stephanie. Welcome to the show. How you guys doing yeah. Welcome welcome welcome okay so first of all before we before we kick this off. Stephanie can you tell us who you are? We all know who that is. So whatever but we don't you want to know about you and then we'll get to you. They will dive into the interview. Stephanie Fam- P. H. A. M. Pronounced Fam- like family tells about you what's your what's your involvement in this project. Hi Okay so I'm Stephanie. Fam often so I- model and I've been modeling for about ten years now and I have experienced an implied nucor gestures for about five years and in the correspondingly. I actually like give my two cents in terms of like the models perspective. Because like I feel like there's a lot of things that the photographer could learn more about the model side that could actually help improve their photos and also communication with the models. So that's pretty much are involved my involvement in terms of like how the course goes I guess myself personally besides model a also acting. I also have my own youtube channel. Who the yeah? I'm always busy workaholic. Content Creator. That's what you are contact. Magritte give us the elevator pitch for you. You and I met a long time ago. You were doing. You've since rebranded but back then you were doing stuff very specific to Nikon and now you've shifted. You've seen the mega you've seen the but you you've rebranded away from being brand specific tells about that journey a little bit so well to be honest. I I had the name that nicotine guy which I chose the day that I started the channel. Which actually we just had. I think it was the eighth anniversary a year anniversary. Forget the but it was definitely the end of January when I started the channel and it was just because I had a bag full of nick on equipment so I thought let's reach out and get the nickel and uses leitch at least but I'd never only looked at nick on gear and only all only used nick on Gade and it got to the point. Basically where was with one of my businesses advises? He kind of was brainstorming with me saying so. What's the best case? Scenario would be what you become an ambassador. But they wouldn't be able to talk about other brands and you wouldn't be able to give your honest opinion if it was negative about nick on gave which. I didn't want that and on the other hand you know. Think of an outsider photography. Gm is going to work with that for guy. No and if you're a food lover you may not want to view a channel Code. Gm Guy so seeing not only doing the economy. How bad just make it my night. But because it'll half of what I'm doing is actually about travel or technique oil eating seafood with my cats. That's not half my content that it's a lot of a lot of it's a lot of it. It's not just Nikon camera by cats are right here. Don't say anything bad because they're looking But I think with Steph. Seeing tra- she was a little bit too modest way. We've been working together for close to three years now. The she was that I think the first model. I will definitely the first model in the states that I really connected with. Getting working with an ongoing basis She still comes all the way up from Philly to New York to work whenever we're filming together and she brings a lot more to the table than just standing in a beautiful APP in front of a camera. So I've learned a lot from her about posing and to be honest about shed juuling and a lot of things about getting the most out of my time and amy good model at you know. I don't need to soften the She knows where I'm going with this but being a great modal isn't about being exceptionally good. Looking a great motivator. Someone who knows that poses knows they Anglesey's professionals reliable. Who's good tool book with Tixx Direction? Who understands the goal of the shoot and helps you get the and often the most amazing models I've worked with? Steph is an exception because she is very beautiful as well. The you wouldn't even notice them on the street it's once they hit their pose that everything lights up for the camera. It's not about looking like you just walked off a magazine cover. Shoot all the time so. It's all of that experience that I really wanted to bring to the series because in any shoot that I have with Steph. At least half of the Pos inspiration comes from her and from her experience and having worked with so many different photographers so she has a lot to bring to the table in the series rather than just dropping in a little sense here and there it was really about trying to show both sides of the process. Because you can't get I think anyway you kind of get consistent good results. If you're not both comfortable in a shoot and it goes twofold efforts a noodle revealing shoot and I think maybe even more so when as implied because if it's new to toot so nothing can accidentally slip into the shot. If it's implied but someone's efforts you don't have established relationship of trust. They may that element of is more going to be show and then I was intending. So let's find the part of the discussion around nude verses implied versus you know what here in the United States the United States is well known for its hypocrisy in in in puritanical. Type behavior right you know. We can show nuclear bombs taking on takeout on tire cities. But if you show a nipple that's the end of the world right so so let's put a fine point on that from the experts. Both of you guys. So what is what like where. How do you and your minds professional content creators? That that play in this genre. How do you define nude verses implied versus porn versus whatever right because people lump all that stuff together? How do you split out? I'll jump in and then if you WANNA tank it's It's I think it's a really good question and I hate to not give a precise answer but I think the fact that that is so imperfectly defined. He's wear a lot of the the issues. Come from that settling again that we were trying to do in. This course is to be clear that what I consider to be implied Abu Bwa or too much and not tasteful anymore will be different to staff will be different to. You will be different in every viewer so you actually need to have that conversation really explicitly and clearly each time with the model. Because they've I've shot with Steph a hundred times now more than that. I know this is what she's cool with this. What she's not cool with the stuff I we haven't shot so better. Check that with her but a lot of it. We can actually take for granted. Now that doesn't mean that if I go and shoot with another model day going to be cool and cool with the same stuff so you need to have those conversations again so if you're showing that shut there have asked sitting on her back. You know if you were saying okay. So it's going to be a new back but once you any private parts so for some people that may mean a little bit of bomb. Crises fine for some will may not at all it needs to be side on. Be Really really specific about it. So if we'RE NOT SHOWING NIPPLES. Does that mean showing the entire breast other? The Nipple is okay or wait intending not to show breasted all. It may seem pedantic but you really want to be totally clear on that. So that that takes the guesswork if before you get to the shoot we've both said Okay. These long laundry list of things Not going to be shot. That's cleared and these specific. Things are what we're shooting for. That takes a Lotta the guesswork out of there and something that we talk about in this series is and I think this is where and it's justified. I think there is a bad reputation in this part of the kind of I don't know there's mud in the water to explain it exactly because there are dodgy photographers out there. Who was saying. We're going to shoot. These actually may be shooting more end up sharing things. They said they weren't going to so. I think the key concept is if we've agreed that X. Y. Z. Said aunt going to be shown in the final image. Then why the hell that I need to be shown at the photo

Steph Nick Stephanie Fam Nikon Stephanie Fam- P. H. A. M. Stephanie Frederik Van Johnson GM Mr Grainger United States Nucor Matt Youtube Nicotine Content Creator Magritte Anglesey Abu Bwa Gade Philly
This new evidence shows nicotine might prevent smokers from contracting the coronavirus

KRLD News, Weather and Traffic

00:31 sec | 5 months ago

This new evidence shows nicotine might prevent smokers from contracting the coronavirus

"Researchers are puzzled over a trend regarding smoking and the coronavirus smokers seem to do better fighting it off a review of several scientific studies support claims that people who smoke may have a lower risk of becoming seriously ill with a corona virus British researchers looked at twenty eight scientific papers and found the proportion of smokers among hospital patients with COPD nineteen was significantly lower than expected experts don't know what to make of it as one put it something weird is going on with smoking and the corona

Copd
Can smoking prevent novel coronavirus

BBC World Service

00:48 sec | 5 months ago

Can smoking prevent novel coronavirus

"Scientists in fronts are investigating whether nicotine may help protect people against corona virus they launched a study after data from a Paris hospital showed that smokers with statistically less likely to be admitted for treatment the cave eight nineteen the health minister alleviates around said research was being carried out visit your soul this call may clinical studies are now being formulated and will be conducted by highly talented university teams in French hospitals making it possible to understand research decipher possibly identify whether we could through nicotine have positive effects in a certain number of patients and under what conditions the scientists will use nicotine patches in the

Nicotine Paris
Emergency room doctors facing pay cuts and understaffing

Vickie Allen and Levon Putney

02:00 min | 5 months ago

Emergency room doctors facing pay cuts and understaffing

"Tonight we're learning more about how the pandemic is affecting some of this country's most important health care workers we spoke with the ER doctors in nearly a dozen states who say they're taking pay cuts of up to forty percent the American college of emergency physicians says cutting benefits and ships could for some emergency rooms to shut down nicotine's has more on the financial fallout E. R. Dr Leslie Simon is chair of the emergency medicine department at the Mayo Clinic and is seeing patients with COPD symptoms daily when you go through the stages of grief and you get paid kind of melted under team just took a ten percent salary reduction a consequence of the hospital's anticipated three billion dollar revenue loss we still have two loans we have kids to send to college we have mortgages Mayo Clinic is among thousands of hospitals across the country losing money fast most make half or more of their revenue from elective procedures which have been put on hold add to those losses at least a thirty percent decline in emergency room visits since the pandemic started due to patients staying at home out of fear of contracting the corona virus do you worry that somebody our rooms across the country are so inadequately staffed back lines may not be at risk I think it's possible I also think a lot of them aren't rests for closing one ER doctor who would not speak on camera told us her hours were cut by about fifty percent and that she is now the only E. R. doctor during her shift down from four making her responsible for up to forty beds Dr Natasha Kay who tested seventeen patients for covert just yesterday agreed to speak if we didn't use her last name we are for afraid to come in to work in the ER and now she says also afraid to lose her job we feel like our jobs are more valuable now than ever it's a little difficult to really digest what happened it doesn't really change our attitude going into work Niki Batiste CBS news New York

American College Nicotine Dr Leslie Simon Mayo Clinic Dr Natasha Kay ER New York Copd E. R. Niki Batiste CBS
Emergency room doctors facing pay cuts and understaffing

WBBM Evening News

02:02 min | 5 months ago

Emergency room doctors facing pay cuts and understaffing

"Tonight we're learning more about how the pandemic is affecting some of this country's most important health care workers we spoke with the ER doctors in nearly a dozen states who say they're taking pay cuts of up to forty percent the American college of emergency physicians says cutting benefits and ships could for some emergency rooms to shut down nicotine's has more on the financial fallout E. R. Dr Leslie Simon is chair of the emergency medicine department at the Mayo Clinic and is seeing patients with COPD symptoms daily you go through the stages of grief when you get paid Adam we all did our team just took a ten percent salary reduction a consequence of the hospital's anticipated three billion dollar revenue loss we still have student loans we have kids to send to college we have mortgages Mayo Clinic is among thousands of hospitals across the country losing money fast most make half or more of their revenue from elective procedures which have been put on hold add to those losses at least a thirty percent decline in emergency room visits since the pandemic started due to patients staying at home out of fear of contracting the corona virus do you worry that some of your rooms across the country are so inadequately staffed back lines may not be at risk I think it's possible I also think a lot of Democrats for closing one ER doctor who would not speak on camera told us her hours were cut by about fifty percent and that she is now the only ER doctor during her shift down from four making her responsible for up to forty beds Dr Natasha Kay who tested seventeen patients for covert just yesterday agreed to speak if we didn't use her last name we are so afraid to come in to work in the ER and now she says also afraid to lose her job we feel like our jobs are more valuable now than ever it's a little difficult to really digest what happened it doesn't really change our attitude going into work you keep it's used CBS news New

American College Nicotine Dr Leslie Simon Mayo Clinic Adam Dr Natasha Kay ER Copd CBS
Food, Dubious Food

Your Brain on Facts

09:33 min | 6 months ago

Food, Dubious Food

"In twenty eleven in Alabama law firm sued fast food chain Taco Bell for dishonest business practices claiming that Taco Bell's seasoned filling couldn't be called beef under USDA standards because they had it tested and it was only thirty five percent beef. The rest was oats and other fillers Taco bell pulled out all the stops to refute the allegation at a cost of more than three million dollars including parody of Saturday morning superhero cartoon show that they had already for reasons super delicious ingredients force fighting. Baron VAUGHN bland. My Name's Moxy. And this is your brain on facts. Researching conspiracy theories and urban legends. Always gets a little wild like. Did you know that people are die hard? Tim Hortons fans because the Canadian version of Dunkin donuts spikes their coffee with highly addictive nicotine. Of course they don't but that doesn't stop people from believing. It will be skipping over. Stories like the fingertip and Wendy's Chili. That was a failed extortion attempt or the mouse in the mountain dew which PepsiCo defended themselves against by proving that the mouse would have dissolved. Let's start with the biggest name and fast food. The Mac Daddy if you will. Mcdonald's easily holds the records for the most urban legends and conspiracy yarns spun around a restaurant. The topic has its own wikipedia. Page and these. Well predate the unduplicated experiment. That was Morgan. Spurlock super size me listeners. Of a certain demographic may remember the Jimbo. You deserve a break today reaching them about the same time as the rumor that McDonald's stretched their hamburger meat out with Nice. Cheap ground up worms. If you've been online for more than a few minutes. In the past decade he will have seen a picture of a factory machine extracting fat tube of Pink Mush or pink slime as the caption frames. It say hello to mechanically separated chicken. It's all fast food. Chicken is made from things like chicken. Nuggets patties also. The process frozen chicken in the stores is made from it. Basically the entire chicken is smashed and pressed recieve bones is guts. All it comes out looking like this and there's more because it's crawling with bacteria it'll be washed ammonia soaked in it actually then because it tastes gross. It'll be re flavored artificially then because it's weirdly pink it'll be died with artificial color but hey at least it tastes good right. There are little bits they are that are nearly true mechanically separated meat is a staple ingredient in ready made frozen and fast foods but it's made from meat cuts not whole carcasses while beef producers commonly treat meat products with small amounts of ammonium side as an anti microbial agent and assessing in a high volume facility meat and poultry processors. Don't soak the meat in ammonia. They treat it with the gas apart from the included items being wrong. There are a lot of things that are missing. Like the fact that McDonald's stopped using mechanically separated chicken in two thousand and three mechanically separated. Beef was banned in two thousand four due to concerns about Bovine Spongiform Encephalopathy Aka mad cow disease and the pink. Slime in the picture is probably what one beef industry magazine writer called. Ammonium treated lean beef trimmings not even chicken at all another glaring omission in the claim. There is nothing in the picture to identify that as a McDonald's facility. Mcdonald's went on the defensive showing how nuggets were actually made and that the mushed up chicken while not especially pleasing to the eye at no point looks like pink. Slime washed down those nuggets with a milkshake. Well there's no milk in that milkshake. There's no dairy of any kind. That's why the menu says shakes and not milkshakes. At least that's the rumor. What are they used instead to make it so creamy pureed cow eyeballs or maybe a little microscopic styrofoam balls for filler or lard or potatoes or seaweed or ground up feathers there are strict definitions food labelling and while. Mcdonald's shakes can't be labeled milkshakes in some areas because they don't contain straight up milk they do contain milk via the soft serve ice cream that's used to make them and they don't contain any of the other things save one. Their ice cream is made from milk. Sugar cream of Corn Syrup and various common preservatives and thinners McDonald's self-serve does contain one item from the Urban Legend List Seaweed specifically encourage Heenan. A safe natural common ingredient bonus. Fact if your food or drink is pink or red in color. Check The label for coaching. Neil a type of beetle whose ground up bodies have been used as a food color for centuries. I'm not suggesting to avoid it unless you're trying to keep kosher. I just think it's interesting. It's probably only listed as natural color. Anyway say you bought more food than you're able to eat in one sitting and you left the rest on the counter for a few weeks. Hey we all get busy. Thanks to all the artificial ingredients in manmade chemicals in boldface defiance of the natural order of things that McDonald's food won't rot. Lots of people have made videos showing the food remaining virtually unchanged after days and even weeks. This is a little bit true but mostly false in case any specify that and not for the reasons you think according to Dr Keith Warner Program Director at the University of Gulf's Department of Food Science and Quality Assurance essentially the microbes. That cause rotting are a lot like ourselves in that they need water nutrients warmth and timed grow. If we take one or more of those elements away then. Microbes cannot grow and spoil food in the example of the McDonald's hamburger. The patty loses water in the form of steam during cooking the BUN is made out of bread and toasting it reduces the amount of moisture this means that after preparation hamburger is fairly dry. When left out open in a room? There's further water loss as the humidity within most buildings is around forty percent so in the absence of moisture or high humidity. The Burger simply dries out rather than rots so no moisture no rot. It's the inverse of the reason. Why the bathroom is the only room in your house where you're locked in an eternal struggle with microbes like mold and mildew speaking of moisture. Who could use a tasty beverage right about now? How about a new COQ? Don't know what I'm talking about. That means one of two things. You're under the age of thirty or the most devious and ingenious marketing effort of all time succeeded or failed either way. The absence of evidence is not evidence of absence. Set would want you to know. That coke created new coq to cover the switch from sugar to corn Syrup to mask the removal of the last remaining coca derivatives or because people would hate it and demand more of what had been renamed co Classic. Take your pick. Pepsi had an effective ad campaign with the Pepsi. Challenge a blind taste test where lifelong coke fans found out they actually preferred the taste of Pepsi. Coke replicated the challenge in private and found the same thing. So in nineteen eighty-five they reformulated coke to be sweeter and put it out as new coq hip trendy with it and now including TV spots with the supposedly CGI. Max Headroom. You can hear more about in episode ninety six. Do not adjust your set. People hated new COQ. The heated the very idea of coping changed. There were letter writing campaigns thousands of calls a day and people. Hoarding original coke. Were boycotting the brand altogether independent bottlers even sued Coca Cola for lost revenue. It was all over the news all the late night talk shows. You couldn't buy that much publicity for. Could you? People began to speculate that. Coca-cola had launched new coq knowing that people would hate it that it would make people want to buy original coke and that everyone would be talking about it. They created it to fail. This isn't as far fetched a notion as you might think a decade or so later when Pepsi Launched Crystal Pepsi. Can you hear that Van Hagar Song Coke Launch? Crystal Tab? Tab was the first Diet Soda and even though Crystal Pepsi wasn't Diet People inflated the two and Crystal Pepsi went out faster than Jenkins and plastic choker necklaces as for the new coq debacle being a deliberate marketing ploy then company president. Donald Cove said some. Cynics will say that we planned the whole thing. The truth is we're not that dumb and we're not that Smart

Mcdonald Pepsi Taco Bell Coke Coca Cola Baron Vaughn Bland Crystal Pepsi Dunkin Donuts Tim Hortons Beef Alabama Nicotine Extortion Pepsico Spurlock
A Minimalist, a Japanese Cowboy, and an Arrogant American Walk into a Museum

Optimal Living Daily

04:02 min | 6 months ago

A Minimalist, a Japanese Cowboy, and an Arrogant American Walk into a Museum

"A minimalist a Japanese cowboy and an arrogant American walk into a museum by Joshua Fields Millburn of the minimalist dot com. I'm standing outside. One of my favorite places on earth. The getty next to an Asian man outfitted in ranchers attire white cowboy hat. Yellow snakeskin boots head to toe denim. The views here are stunning even under a ceiling of cerebral clouds. You can see miles in every direction. I think I finally understand the true meaning of the word panoramic with a galaxy of green hills to the south downtown. La's few skyline to the east in a string of Ruby tail light. Scorching the congested four or five to the north. The Sun is preparing his descent into the hills of Santa Monica to our West Casting. Long angular shadows before disappears behind the Pacific's metallic horizon like a glowing coin placed carefully into a wishing. Well I like your hat. I say to the denim clad man towering over him even with his he'll snakeskins by like a two he responds definitively with a thick Japanese accent and a nicotine smile his Kanaan's dressed in conviction. I love living life. He says with no further explanation as if everything that needed to be explained about him about life in general is contained inside those four words. Although we've never met. The two of US are bystanders. In the museum's Afternoon Architecture tour which is just wrapping up our tour. Guide points out that he thousand-year-old grand pillars framing. The impending sunset behind us and American man is complaining to his wife about the cold breeze about the clouds overhead about the lack of amplification in the tour guys voice. He's been pompously protesting the entire tour. Apparently the universe has conspired to ruin his day from the sound of his steadfast objections. Everything here is ill suited for his presence. There should be something out of place with five foot tall. Japanese cattleman standing among rembrandt paintings and modern architecture in southern California. But there's not and yet something is off. With the everyday American monitoring about the world's inadequacies tuning out the American. For a moment I let the cowboy. No he would fit in well back home in Montana. We have a lot of big hats and pickup trucks. I tell him. He says he likes that part of the country. The Wild Western he calls it and then recommends. A book called the solace of open spaces by Gretel. Erlich although the book is out of print I later find a copy online and discover for myself erlichs gorgeous ruminations on life on Wyoming's high plains despite the cowboys uncommissioned appearance or maybe because of it is obvious that he would fit in almost anywhere. His posture his gate. Us gap toothed Grin speak volumes about this man's interior life. He seems composed resolute content many miles from in a word he's confident conversely no place seems fit for the babbling. American his regal standards and his poor expectations make assimilation a constant problem after another snarky comment directed toward his wife gave him a searing eiffel and his gaze immediately searches for his feet his voice maybe the loudest and the pack but volume isn't a measure of confidence. A truly confident man need only whisper to be heard. The Sun is completing its coin. Toss into the ocean or group outlined in twilight looking over the cowboy surveying his staunch temperament. I realized that his confidence is simply an external display of a rich interior life. Congruency between his internal and external world's Oregon's on the other hand is the opposite of confidence of near of composure. Incongruence at had seen it does why confident man is able to coalesce with any group anywhere in arrogance man. Nowhere at all confidence holds up under scrutiny whereas arrogance fractures with the slightest crack and as human beings. We all have cracks sooner or later. A spotlight has shown in the arrogant. Man's pomposity is exposed seeping through the veneer while the confident man just admires the beauty of his flaws.

United States Getty Joshua Fields Millburn Santa Monica LA Oregon Nicotine Incongruence Erlich California West Casting Kanaan Gretel Montana Wyoming
House passes bill to ban the sale of flavored e-cigarettes

KYW 24 Hour News

00:23 sec | 7 months ago

House passes bill to ban the sale of flavored e-cigarettes

"What else is approved a bill to ban the sale of flavored E. cigarettes and other flavored tobacco products the bill would place new restrictions on the marketing of E. cigarettes and bad flavors in tobacco products including menthol cigarettes the bill also would place a new excise on nicotine the bill Nelson moves to the Senate where approval is considered unlikely the trump administration opposes the

Senate Nicotine Bill Nelson
House approves bill to ban the sale of flavored e-cigarettes

WBT Afternoon Programming

00:28 sec | 7 months ago

House approves bill to ban the sale of flavored e-cigarettes

"The house approved a bill barring the sale of flavored vapes as well as traditional menthol cigarettes house speaker Nancy Pelosi says the ban will help curb the spread of nicotine use among the nation's youth we are protecting the health of the millions of young people who are at risk from big tobacco's deadly products it's unlikely the Senate will take up the bill and president trump has threatened a veto because Rachel Sutherland opponents fear of flavor band will lead to increased tobacco use by younger

Senate President Trump Donald Trump Nancy Pelosi Nicotine Rachel Sutherland
House passes bill to ban the sale of flavored e-cigarettes and tobacco products

WBT Afternoon Programming

00:36 sec | 7 months ago

House passes bill to ban the sale of flavored e-cigarettes and tobacco products

"Number on Capitol Hill this afternoon the house just passing a ban on flavored E. cigarettes the two hundred thirteen of one ninety five vote the house approved a bill barring the sale of flavored vapes as well as traditional menthol cigarettes house speaker Nancy Pelosi says the ban will help curb the spread of nicotine use among the nation's use we are protecting the health of the millions of young people who are at risk from big tobacco's deadly products it's unlikely the Senate will take up the bill and president trump is certain to be telex Rachel Sutherland opponents fear of flavor ban will lead to increased tobacco use by younger

Senate President Trump Donald Trump Nancy Pelosi Nicotine Rachel Sutherland
House approves bill to ban the sale of flavored e-cigarettes

WBZ Midday News

00:38 sec | 7 months ago

House approves bill to ban the sale of flavored e-cigarettes

"Seven the house of representatives approving a bill today aimed at curbing tobacco use among teenagers including vaping the bill would ban flavored tobacco into vape juice including menthol Massachusetts representative Richard Neal supporting the measure we propose to establish a federal excise tax on nicotine and vaping products to make sure that they're treated the same as the nicotine in combustible cigarettes critics say the bill goes too far doesn't take into account adults who use vaping products to quit smoking the bill would still have to pass the Senate and be signed by president trump before

Representative Richard Neal Nicotine Senate President Trump Massachusetts
39 states investigating Juul's marketing of vaping products

KCBS Radio Midday News

00:34 sec | 7 months ago

39 states investigating Juul's marketing of vaping products

"Investigators from thirty nine states will look into the marketing and sales of vaping products by San Francisco based Juul labs including whether the company targeted young people and made misleading claims about nicotine content in its products attorneys general from Connecticut Florida Nevada Oregon Texas say they'll be leading the multistate investigation into Joel which is also facing numerous lawsuits by users who say they became addicted to the company's products Joe released a statement saying it has halted television print and digital advertising and eliminated most flavors in response to the

San Francisco Juul Labs Texas Joel JOE Marketing And Sales Nicotine Connecticut Nevada Oregon
The God Concept in Alcoholics Anonymous

The Scathing Atheist

05:13 min | 7 months ago

The God Concept in Alcoholics Anonymous

"It's probably an indicator of something. Deeply Miss Wired in my psyche that I've thought to myself multiple times man. I sure wish I used to be an alcoholic so that I could prove that step would as program is a Lotta Shit step one. A is seven step. Recovery Program is but God though right to blanket statement. That says it's literally impossible to quit drinking if you aren't religious. As one of those statements that lends itself to empirical testing and like all religious statements. That do that. It fails the test consistently there is no correlation between religiosity an addiction recovery. We'd we'd have a lot more data to work with of course if they would release their own recidivism rates but in this instance. I feel like the fact that they won't as the only data point. We really need any but to this point in my life. I've always seen two ways that you could explain this rules existence in light of the fact that is demonstrably untrue. The more cynical interpretation of course is to say that people at rock-bottom are more susceptible religious indoctrination and won't be able to fight you off as well now if you're inclined to be more charitable though you can also look at it like the bloody volleyball that Tom. Hanks talks to in castaway. Right a person who's tried and failed to quit drinking especially a person's failed repeatedly at that. Might need an imaginary hand to hold your the only way that they're likely to believe the person you can do. This is if that person is lying about who you is in this scenario so you know they tack on some God Shit and they say no matter how insurmountable the goal might seem. Our guy is dependent so he can handle it. Of course even that. More charitable interpretation. Even if it's all the fucking way correct would be insufficient to explain the first step because you can get all that shit without insisting on God bully right. You could just have that one of the available menu items and still gain all the same benefits from it now in the past. That's where I've left it intellectually because let's face it the fact that the charitable explanation just doesn't add up as well as the cynical one isn't usually in need of further review when we're talking about religious questions but I've been thinking more and more about this since I quit smoking. And another possible factor occurred to me the other day so first of all. Quick Update. By the time you hear this it will have been ten weeks since my last cigarette. Thank you thank you know. Seriously thank you because if I hadn't done it in such a public way and if you guys hadn't been holding me to account and if so many of you hadn't reached out to help it probably wouldn't have been able to do it so thank you and to be honest like at this point. I'm so damn confident that like I'm saying it's been ten weeks even though I'm recording this motherfucker. A week in advance and throughout. I've been trying to keep my eye open for what purpose God might have served in all of this. You can't help but replay this whole nine week ordeal. Imagine what if I had been Christian throughout because you know to be perfectly honest with you. Quitting to this point hasn't been as hard as I feared it would be big in the first couple of days. Were pretty miserable. I'm hardly all the way out of the woods. But ultimately I found it to be much less difficult to my fears had led me to believe it would be imagine Christian right and even better measuring just became a Christian or like you know I was already a Christian but I just rededicated my life to Christ or whatever exactly the kind of thing that Christians might do when they're turning over the kind of leave that you would turn over right before you quit smoking. After thirty years so Christian me praise to mighty Jesus to hold my hand. Carry me through this. You know because Baikal e a higher power strong enough to do it and then Lo and behold I observe all the same shit that atheist may just observed quitting turns out not to be as hard as I thought it would be. But it's no longer though because I was mistaken about the level of difficulty is because God was on my side. You know. Maybe the guy was could've done it but he certainly wouldn't have done it. So painlessly praise the Lord. Hallelujah of course in this instance. God didn't actually help me quit smoking. I quit myself and then I gave him all the credit. So what purpose did he serve? Did we just land back on that cynical interpretation we started with will consider this? There are a lot of things that I should do with my life and most of them are easier than giving up thirty year nicotine habit just demonstrably easier than that. I should give more money to charity. I should volunteer my time. I should eat better. I should exercise more. I should be a better husband. I should get angry at fewer inanimate objects and if I just proved to myself that I can quit smoking. Rake Ed traditionally considered to be one of the hardest. Damn things a person can be called upon to do how the fuck can justify continuing to fuck up all that other stuff. How can I rectify ability to quit smoking? But my inability to be as attentive as should be Lucinda. Well God sure makes a great excuse. Doesn't he after all if I quit smoking not because of my own willpower but rather because I beseeched God and he heard me? Well I don't have to do all this other stuff. I I can't go pastoring God. Every time. There's a problem in my life now can I? Sometimes I gotTA handle this shit on my own. I don't have the kind of willpower. It takes to quit smokin or quit. Drinking I failed at that shit repeatedly. Only God could do that. Look I'll admit it can be kind of intimidating to realize that something you've thought yourself incapable of for a really long time was easier than you thought it would be. What other comfortable limitations are illustrating? What else is possible? Don't get me wrong. I'm all for believing in yourself but if you do it correctly it can be downright

Hanks TOM Nicotine LO Lucinda
"nicotine" Discussed on Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

09:38 min | 8 months ago

"nicotine" Discussed on Real Life Pharmacology - Pharmacology Education for Health Care Professionals

"CQ Is the one that I've seen gene used most commonly with nicotine patches. I I think it is important to note that we do have three primary dosage strengths. So we've got a seven milligram patch of fourteen milligram patch in a twenty one milligram patch in really there is A lower end weight restriction. But for most adult patients. They're they're above that so if somebody super low weight You Might WanNa double check and look that up but by and large we look at the number of cigarettes smoked per day and judge our initial dosing off. Offer that in most cases so obviously there could be a situation clinically were maybe a patient has tried patches in the past and they didn't tolerate the high dose or something. You might start at a at a lower dose in that type of situation but Going off of the cigarettes smoked per day. If we've got a patient isn't that is smoking eleven or more. We're going to generally go with the twenty one milligram patch and start with that. That's the the highest dose. Does there if it's ten or less than we might start with. Fourteen milligrams as far as the the patch. Goes there and end so tens. Ten's a good number to Kinda remember in an easy number to remember Based upon the number of cigarettes smoked there so if we got above that twenty one milligrams below that Fourteen milligrams so with that dosing. How long do we do the dosage form so usually or what's approved is twenty one milligrams That dose for six weeks and then we would do fourteen milligram. Dan Patch for a couple of weeks. And then the seven Milligram Patch for a couple weeks so kind of a of a taper down with a longer period of time on the higher dose us now for starting at that lower dose or the medium dose fourteen. Milligrams that's fourteen milligrams for six weeks and then seven milligrams for two weeks weeks there so that that dose is is generally at least initially going to be based on The number of cigarettes smoked From a mechanism of action standpoint. Obviously we're replacing nicotine That's our objective. Our goal to to replace that nicotine so patients feel. They don't need it necessarily through smoking cigarettes so nicotine itself In the rain essentially vines nicotinic and cholinergic receptors which can produce a stimulating type of fact In it can also impact kind of the rewards center on the the LIMBIC system which that can really fuel That reward can fuel that addiction to cigarettes. Which is why so many patients struggle to Come off smoking Back Kinda relating the patch to clinical judgement. So we talked about the number of cigarettes. Smoked It's always important to us. Clinical judgment. I if you've got a patient that's experiencing adverse fact intolerability due to a higher ear dose. Obviously we're probably going to reduce that dose same thing if you've got a patient reporting Significant withdrawal symptoms news. You know that's a situation where we we might escalate the dose an go up you know if you started a fourteen milligram. Patch they're experiencing those withdrawal symptoms symptoms. We might bump them up to the twenty one milligram patch. And here's a shock to you patients. Maybe don't exactly report Exactly exactly how much. They're smoking as well. Just like drinking alcohol and other things we tend to. Maybe Underestimate how much of a negative. The thing that we're doing so Very important to to use that clinical judgment and recognize that that patients might not be exactly Accurately portraying how much they're doing something or they're smoking in this case if you other clinical pearls with regard it to the patch So only one at a time. I think that's kind of common sense. this specific patch. You cannot cut so something like a lighted arm patch for pain. You can cut that type of patch but nicoderm replacement patches nicotine replacement patches. You cannot cut them. Essentially what's going to happen is you're going to lose some of the the drug and obviously reduce effectiveness. There you want to a non in Harry area clean area on the body usually most patients I've seen on the kind of the back of the arm have seen some kind of upper chest area Korea that type of of location as well. They're now wearing the patch. This is something that has definitely come up before in clinical uncle practice. How long do I have to wear this? How long can I wear this patch? So they are intended to be once daily and really in most patients. We're GONNA use them sixteen to twenty four hours and probably the biggest. The two big things is that I remember with how long to determine To wear the patch is are they having adverse effects at night and specifically adverse effects like insomnia vivid dreams. If that's problematic at night that definitely could be because of nicotine concentrations so in that situation we might say hey taken off at night now that can be balanced with morning cravings so. So if you've got a patient that it's like Yup I get up the first thing I do during the day as my cigarette. That's how I get going. That's how I do my thing That's a situation in where you're probably GonNa want that nicotine in the body because remember these. These patches have a slower onset. They're intended to be longer longer acting nicotine replacement. It's not like a piece of Gum. It's not like an inhaler. You're not going to get that quick. Absorption from nicotine. Patch that that you would with some other dosage forms that are meant for acute relief. So that's kind of some of the downsides of the patch and the kind of the ying and the Yang the good and the bad so to speak. Is that slow onset so it's it's not going to be used for quick relief and and one other downside is throughout the day if patients have really strong cravings You can't adjust the dose of the patch. She can't somehow how did it up. And and increase the dose. That's being delivered from that patch. And even if you could that dose would take a while to get get ramped up because it takes time for that drug to pass through the skin so Those are definitely some important pearls To think about when we're talking talking about Nicotine Patch administration and use of it Let's wrap up the first section here talking about adverse effects facts so I mentioned a couple Insomnia the dreams patients are having those. That's probably candidate that we're likely going to take that patch off at night night Other adverse effects I have seen have heard of Gi upset which tends to be obviously a lot more common. If you're oh you know doing a nicotine gum or something because that nicotine is going right into the got their With the patch it is possible. Maybe a little less likely Headache and then of course with any topical administration there's potential for a skin reaction so You know keeping that that let's say clean obviously not placing the patch right on the same exact spot over and over and over again that may lead to some worsening of of the year ISSUE THERE SO I keep that in mind obviously if somebody's reporting really severe reaction Rashes Spreading. It's getting worse You No it's it's painful it's weeping. It's you know other Worrisome symptoms Yeah you've got to educate your patients to report Those issues to you if if they are having problems that maybe something else is going on infection or or whatever so I think that wraps up adverse effects We'll take a quick break. Then we'll finish finish up on drug interactions if you're looking for board certification study material be CPS GP ambulatory care BC the MTA or nap. LEX material We've got lots of cool stuff. GOING ON AT MED one one dot com slash store. You can find links to all the resources we have also uniquely Just released a drug interactions book that I will cover many of the interactions that. I'm I'm covering today. Today is with regards to nicotine and smoking. So you definitely go check that out. I've got.

nicotine Dan Patch MTA mechanism of action onset Korea BC Headache Insomnia
"nicotine" Discussed on Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

09:38 min | 8 months ago

"nicotine" Discussed on Real Life Pharmacology - Pharmacology Education for Health Care Professionals

"CQ Is the one that I've seen gene used most commonly with nicotine patches. I I think it is important to note that we do have three primary dosage strengths. So we've got a seven milligram patch of fourteen milligram patch in a twenty one milligram patch in really there is A lower end weight restriction. But for most adult patients. They're they're above that so if somebody super low weight You Might WanNa double check and look that up but by and large we look at the number of cigarettes smoked per day and judge our initial dosing off. Offer that in most cases so obviously there could be a situation clinically were maybe a patient has tried patches in the past and they didn't tolerate the high dose or something. You might start at a at a lower dose in that type of situation but Going off of the cigarettes smoked per day. If we've got a patient isn't that is smoking eleven or more. We're going to generally go with the twenty one milligram patch and start with that. That's the the highest dose. Does there if it's ten or less than we might start with. Fourteen milligrams as far as the the patch. Goes there and end so tens. Ten's a good number to Kinda remember in an easy number to remember Based upon the number of cigarettes smoked there so if we got above that twenty one milligrams below that Fourteen milligrams so with that dosing. How long do we do the dosage form so usually or what's approved is twenty one milligrams That dose for six weeks and then we would do fourteen milligram. Dan Patch for a couple of weeks. And then the seven Milligram Patch for a couple weeks so kind of a of a taper down with a longer period of time on the higher dose us now for starting at that lower dose or the medium dose fourteen. Milligrams that's fourteen milligrams for six weeks and then seven milligrams for two weeks weeks there so that that dose is is generally at least initially going to be based on The number of cigarettes smoked From a mechanism of action standpoint. Obviously we're replacing nicotine That's our objective. Our goal to to replace that nicotine so patients feel. They don't need it necessarily through smoking cigarettes so nicotine itself In the rain essentially vines nicotinic and cholinergic receptors which can produce a stimulating type of fact In it can also impact kind of the rewards center on the the LIMBIC system which that can really fuel That reward can fuel that addiction to cigarettes. Which is why so many patients struggle to Come off smoking Back Kinda relating the patch to clinical judgement. So we talked about the number of cigarettes. Smoked It's always important to us. Clinical judgment. I if you've got a patient that's experiencing adverse fact intolerability due to a higher ear dose. Obviously we're probably going to reduce that dose same thing if you've got a patient reporting Significant withdrawal symptoms news. You know that's a situation where we we might escalate the dose an go up you know if you started a fourteen milligram. Patch they're experiencing those withdrawal symptoms symptoms. We might bump them up to the twenty one milligram patch. And here's a shock to you patients. Maybe don't exactly report Exactly exactly how much. They're smoking as well. Just like drinking alcohol and other things we tend to. Maybe Underestimate how much of a negative. The thing that we're doing so Very important to to use that clinical judgment and recognize that that patients might not be exactly Accurately portraying how much they're doing something or they're smoking in this case if you other clinical pearls with regard it to the patch So only one at a time. I think that's kind of common sense. this specific patch. You cannot cut so something like a lighted arm patch for pain. You can cut that type of patch but nicoderm replacement patches nicotine replacement patches. You cannot cut them. Essentially what's going to happen is you're going to lose some of the the drug and obviously reduce effectiveness. There you want to a non in Harry area clean area on the body usually most patients I've seen on the kind of the back of the arm have seen some kind of upper chest area Korea that type of of location as well. They're now wearing the patch. This is something that has definitely come up before in clinical uncle practice. How long do I have to wear this? How long can I wear this patch? So they are intended to be once daily and really in most patients. We're GONNA use them sixteen to twenty four hours and probably the biggest. The two big things is that I remember with how long to determine To wear the patch is are they having adverse effects at night and specifically adverse effects like insomnia vivid dreams. If that's problematic at night that definitely could be because of nicotine concentrations so in that situation we might say hey taken off at night now that can be balanced with morning cravings so. So if you've got a patient that it's like Yup I get up the first thing I do during the day as my cigarette. That's how I get going. That's how I do my thing That's a situation in where you're probably GonNa want that nicotine in the body because remember these. These patches have a slower onset. They're intended to be longer longer acting nicotine replacement. It's not like a piece of Gum. It's not like an inhaler. You're not going to get that quick. Absorption from nicotine. Patch that that you would with some other dosage forms that are meant for acute relief. So that's kind of some of the downsides of the patch and the kind of the ying and the Yang the good and the bad so to speak. Is that slow onset so it's it's not going to be used for quick relief and and one other downside is throughout the day if patients have really strong cravings You can't adjust the dose of the patch. She can't somehow how did it up. And and increase the dose. That's being delivered from that patch. And even if you could that dose would take a while to get get ramped up because it takes time for that drug to pass through the skin so Those are definitely some important pearls To think about when we're talking talking about Nicotine Patch administration and use of it Let's wrap up the first section here talking about adverse effects facts so I mentioned a couple Insomnia the dreams patients are having those. That's probably candidate that we're likely going to take that patch off at night night Other adverse effects I have seen have heard of Gi upset which tends to be obviously a lot more common. If you're oh you know doing a nicotine gum or something because that nicotine is going right into the got their With the patch it is possible. Maybe a little less likely Headache and then of course with any topical administration there's potential for a skin reaction so You know keeping that that let's say clean obviously not placing the patch right on the same exact spot over and over and over again that may lead to some worsening of of the year ISSUE THERE SO I keep that in mind obviously if somebody's reporting really severe reaction Rashes Spreading. It's getting worse You No it's it's painful it's weeping. It's you know other Worrisome symptoms Yeah you've got to educate your patients to report Those issues to you if if they are having problems that maybe something else is going on infection or or whatever so I think that wraps up adverse effects We'll take a quick break. Then we'll finish finish up on drug interactions if you're looking for board certification study material be CPS GP ambulatory care BC the MTA or nap. LEX material We've got lots of cool stuff. GOING ON AT MED one one dot com slash store. You can find links to all the resources we have also uniquely Just released a drug interactions book that I will cover many of the interactions that. I'm I'm covering today. Today is with regards to nicotine and smoking. So you definitely go check that out. I've got.

nicotine Dan Patch MTA mechanism of action onset Korea BC Headache Insomnia
"nicotine" Discussed on Mayo Clinic Talks

Mayo Clinic Talks

11:35 min | 10 months ago

"nicotine" Discussed on Mayo Clinic Talks

"Well that's nicotine how `bout bupropion. So it'd be appropriate as an antidepressant depressant. We call it an atypical antidepressant. We think it works by increasing dopamine in the reward center it probably has some other impacts as well And it has been shown to be helpful for the people to stop smoking if you look at the outcomes of people who used as a single agent in combination with anything else and any single agent nicotine replacement therapy the patch or gum or one of the others. The outcomes are about the same about fifty to sixty percent improvement in six month. abstinence rates compared with placebo or no treatment so it is effective and in patients who Have a history of depression depression. I think it may be its preferred. There is some data to suggest that those patients will less likely get Low mood food when they're quitting and sometimes that does happen especially in people with a history of depression so if you have a person who has had a history of major depression you treat them only with nicotine replacement therapy. They're likely to get low mood in. That may result relapse is less likely to happen with appropriate and the only other advantage I'd see for B. Program is that It seems to reduced the Post Cessation Weight Gain that people experience It definitely better than nicotine replacement therapy in that sense and so if someone is very wait concerned. They've typically say well I if I will gain a few pounds I probably will start smoking again. Be propium may be an excellent let choice for them. Okay and then how about Rent Cleaner Shanta Cheson. So it's the newest it was but it's been around a long time now. It's been it was released in in two thousand six and it works in a unique way. It it is a what's called partial agonists. So there's a the nicotinic receptor this the the Alpha Alpha Four Beta two which is the is the high affinity receptor we think is responsible for the addictive properties of nicotine. When it's activated activates debates the reward center and that's what causes the positive reinforcement for using tobacco in the nicotine in tobacco this drug it partially stimulate that receptor so they get a little bit of impact from that and then it it remains on the receptor in blocks it from being stimulated anymore so it does both? It's a little bit of agonists stimulation and then blocking effect and it's very effective it. It results in abstinence rates that are Two to two three times so a one hundred. Two hundred percent better outcomes at six months compared with placebo treatment and in head to head tests now al against Nicotine Patch and against Proton it performs better in those randomized trials. Is there a black box warning with that drug. It carried a black box warning for a number of years in only in the past. Oh I think it was in two thousand eighteen. Possibly twenty seven. But it's better than a year to two years that the the warning has been removed and that warning had to do with neuropsychiatric adverse effects so people who did not even have a history of psychiatric illness Had behavior changes suicidal thoughts and even suicidal behaviors There was a very large study that was published pushing twenty sixteen looking at appropriate Jon Patch Nicotine Patch Andrew and clean compared with each other and to placebo and they Accrued eight thousand patients in that study. Two thousand patients in each of those four arms and half of the patients recruited had mental illness history and the point of the study. Really really look at the safety question. This that caused the the boxed warning In the outcome of that was first of all Verandah mclane seemed to be superior to appropriate Nicotine Patch for the absence outcompeted. Also there were no safety issues. The risk of having near neuropsychiatric gastric symptoms was the same with each and they were very low rates of all of those symptoms with all of the treatments. Do you ever combine pharmacologic agents. Yeah we do so. These drugs work in different ways and that often gives you an opportunity to see well. Maybe there's some either additive or even synergistic effects between them and so there have been studies that have looked at Be Appropriate in Verna clean together and those two drugs appear to work the best together in people who have who are highly dependent And typically heavy smokers so if you in the light smoker Low dependent smoker. Probably that combination therapy is not needed but thirty pack thirty cigarettes a day Very highly dependent That combination would be helpful. People also looked at nicotine replacement therapy along with the appropriate or with VERANA clean and those combinations combinations appear to be also effective may have some additive effect. How effective are we as a primary care? Health Care Health okay provider in getting patients to discontinue tobacco. So I'M NOT GONNA I. I'm not going to discourage providers I think we we do a reasonably good job. They're all kinds of things on our plates when we're dealing with patients in even though some of the conditions were dealing with tobacco related. It's it's sometimes hard to bring it up as to the top of the list So I really think we need to develop systems approaches to help us Treat them And we're working on some of those and now with our electric health record those some of those systems approaches really are in our grasp I would say that most providers probably feel elbit discouraged. They feel that they're inexpert at counseling and so they don't do it and they feel uncertain about the drugs and they and they don't use them or they use them two two little or or not for long enough so I encourage people to. It's like any other treatment. get familiar and comfortable with with a couple of these. If you say I could get comfortable with nicotine patch and then add gum get comfortable with that look at the some of the literature similarly for Verana clean and then Provide just basic supportive counseling. It can be no more than I really advise you to quit smoking and and I'm very willing to help you in there. Some things that can help you do it. You don't have to be a professional counselor. Seems like from what you said earlier though that this dependence dependence is so strong that it's effective only when you put a lot of effort into it whether it's from the provider from counselors but For us to just tell a patient recent. Stop Smoking or here take this prescription. Go Away probably not going to be all that effective. It's not worth less so you are asking me earlier. What's the arrayed of quitting if people just do it on their own with no support two to three percent? If a doctor gives advice and says I'll give you this medication. This may help you. You actually double that. It's now five to six percent so it's not worthless. Patients do listen to that but not as effective as some of these other approaches talked about. Yeah I know in the past when we did more chest XRAYS Sometimes find a little area of concern and lead to ct skin that would get the patient quite concerned That often lead to them. Saying I'm through especially if it came back negative Through smoking and in some it seemed to be effective for long-term others. It seemed like it was short term but I don't know if that really is ever been looked at of finding a health scare. Does that the two. So so there's data on both sides and I think will will accumulate data through now lung cancer screening so As his most people know C. T. screening low dose E. T. screening is now recommended for people who who've been heavy smokers are over a certain age their specific criteria. What we don't know In our lung cancer screening programs is the question you just asked if people get a good report fort. Does that right. What what does that have that say? Well I dodged a bullet. Maybe I should quit smoking or does it say oh. Wow Dodge the bullet. I think I can keep smoking. We don't know the answer to that. There's some data from some other sources to suggest that healthcare's often get people's attention and help them quit so for example in the hospital. If you come with an acute myocardial infarction and you're a smoker. The chances that you'll stop smoking in the next six months are about fifty percent so obviously obviously very attention getting And some illnesses are like that. Now does that mean that those patients are at low risk for relapse because they remember that not necessarily are their counseling groups or support groups in the community where patients can go to help them. Stop Smoking some communities is have them most. Don't there there is a nicotine anonymous or in a that is available in some communities Some communities will have tobacco treatment available In the hospital may support some group support groups. We have a small group support program that we provide our nicotine dependence center but But but not usually and so what I often ask. Patients to do is to try to get that support online. And there's a actually a website that we you work with you Mayo. Clinic has provided content and we are partners with them. It's called Truth Initiative and the website is called become an x Dot Org dot. Org and they have in their support community quit plan and other things so if people can't access care in other ways as online and they can usually find. There are some bad things but I can vouch for become an ex because again mayo. Clinic has provided a lot of the content for that an ex- The X. yet become an e. x. all one word dot. Org All right finally one last question. There are a lot of devices and and treatment recommendations out there many of them online that Promote smoking cessation. Are there things out there that are very unlikely to help patients and there are a host of things that are elected to help patients the vast majority of them. It's difficult to make definitive statements because they've never been subjected to any sort of evidence evidence that we would agree together that makes sense. It looks like it actually does work and so everything from devices Things that you click on your ear or are laser or hypnosis which has been looked at in randomized studies and doesn't seem to help just funny anecdote I've had some patients patients More than a handful who've been to someone and I don't know if he's still operating in Boston who was called the Mad Russian and he would take people glidden do hypnosis of sort and other things and they would walk out apparently never to smoke again. It didn't work for most of the patients I saw as you might. Yes uh-huh we've been discussing the management of nicotine dependence with Dr Taylor Hayes an internist and director of.

nicotine nicotine dependence depression dopamine Verandah mclane acute myocardial infarction bupropion Verna Dr Taylor Hayes Boston Truth Initiative VERANA Verana Mayo C. T.
"nicotine" Discussed on News-Talk 1400 The Patriot

News-Talk 1400 The Patriot

04:39 min | 1 year ago

"nicotine" Discussed on News-Talk 1400 The Patriot

"Weekend with us as use of electronic cigarettes by middle and high school students has skyrocketed so has the number of parents on aware that they have nicotine addicted children here are tips for parents worried about their kids and vaping from gene o'donnell health policy reporter at USA today Jane your advice well my biggest advice would be odd not to freak out because the not that it's funny but it is we've gotten very worked up over a problem that is linked to vaping but it's not the people there ending up in the hospital with a long illness is almost without exception or also vaping T. H. C. so if your child is sleeping naked teen anti H. C. and they're getting their T. H. C. street dealers which most kids would have to under age eighteen or twenty one that's what you need to worry about the most. vaping nicotine is risky but not risky like that it's not the it's not leading AP sending young people to the hospital but it is a very difficult substance nicotine that is to get off of users secretive gene so one of the signs that your kids are vaping among the things I mentioned in the story worse things like getting up from the table a lot having no run off and it excusing themselves you know kids might not want to hang around with their parents too much the dinner table but in an ability to to just spend any length of time in the same room I guess I would say more than usual kind of the one of the public knowledge yes I spoke to said kind of that this sneaky and what's it like averting their eyes like looking looking guilty that's one of them exit they certainly excessive costing breathing problems like if your kid plays a sport for example and then they're getting away more winded than they used to that's a good that's a an important sign because his if this is. half ironically very popular among sports teams even though it really hurts the young people's indoor ends and then of course you find a device that's a good. you likely sign we're speaking with gene o'donnell health policy reporter at USA today pieces gold is my kid vaping if so what's and how do I help them quit so what do you do if you find out your kids are addicted to vaping well I would certainly the first stop in all cases should be the doctor's office but what I'm hearing from talking to school nurses is that the pediatricians often don't know what to suggest this is a new thing and having to get young people off of nicotine and they're having to go through some pretty serious programs they're being pulled out of school they're having to take classes you know that signal remotely having to time every day after school at some places. in the special station programs they call them there are medications they're approved for this sort of thing but none of it's really recommend it none of them worked were were recommended for young people but of course neither was nicotine so the risk of your your kids being harmed by a nicotine replacement therapy which is generally over the counter one of the guns are the patch is is is pretty were about so yeah you really do have to have to you know get get them off it is finished and then and also look at why they're vaping nicotine is that that is because in many cases it's. simply peer pressure but is it peer pressure and that's going to lead to a far more dangerous peer pressure at the doctor the psychiatrists from Hazelden Betty Ford center that I spoke to said it really is if you're if you're young person is vaping nicotine particularly as some of the very young ages or hearing this election is twelve or thirteen and middle school the ticket they're hanging around with kids that are that's going to be bad news if they're doing that they're going to be ahead of the curve on all the risky behavior because even though the kids says everyone's doing it at school if everyone and his group his or her group it's not everyone it's it's really one in five one and four kids in high school and middle middle school top. distinction Jayne o'donnell health policy.

nicotine
"nicotine" Discussed on 710 WOR

710 WOR

02:04 min | 1 year ago

"nicotine" Discussed on 710 WOR

"Contains nicotine nicotine is an addictive chemical you're probably would not be surprised how many people use free public wifi were it's offered very convenient but there's a huge downside in maths the cyber hacker it's no doubt somewhere lurking seeing if for fun or profit he can find a way into your machine I mean y'all you almost half the count on that happening I mean it's it's too rich environment you're hacker you have some skill you go to a place where a lot of people are accessing free wifi they're sitting docks and if your hacker just you is see what you can do see what now where you can plant what kind of data you can get you may hit paydirt with somebody you never know do you need to avoid this you need to be able to wave to find a way to go on public wifi because you're in a lot of places where it's offered you need to be able to use it with security and now you can there is a way to ensure that your online activities are private and shielded for all intents and purposes invisible and thus anonymous it's called VPN virtual private network a virtual private network in crypts your connection every thing from your devices your I. S. P. is encrypted but more than that it's invisible it's a single connection nobody shares it you're the only one on it and nobody can see it not the hacker who's working in a private so why are public wifi network area it really is it's it's the best way to have total invisibility total security Norton makes the best VPN Norton secure VPN it encrypts your message in a way that nobody.

nicotine
"nicotine" Discussed on 850 WFTL

850 WFTL

03:35 min | 1 year ago

"nicotine" Discussed on 850 WFTL

"Nicotine is an addictive chemical former show he is curly he has the morning off I'm hearing back from her I'm here and you're there so aboard chat to our last caller look I I understand your frustration it's been part of our frustration how the Republicans and and and even this administration of how they how they communicate a message and Republicans for the longest time not communicating a message effectively but you don't have to be deceitful when you don't have to say things you don't believe and you don't have to play dirty that's the beauty if you're a conservative you don't have to play dirty you don't have to make stuff up and she said you know after the congressional shootings they should have gone in in right and and and blamed right after the death the the the Democrats were to blame them specifically for just like they're doing to us and I told her the reason Republicans and get service don't do that is they don't believe it they understand that the you know in a society that you when you have you're going to have free speech and people are going to go over the top there always going over the top I understand that what happens in a Republic it's meant to be that way the whole system was set up so people can see you out the most vile rhetoric at each other and we don't know but if we don't end up for the most part in a civil war or people killing each other over the politics then you have the people dad commit mass shootings as I've said three hundred thirty million people in the country roughly five to ten of these type of specific crimes a year sometimes fewer they have increased and so most conservatives and Republicans look at it go you know terrible that these things happen what could we best do well are we going to change the way the society is not really ever getting rid of video games now I did mention earlier begin your red pot get rid of pot now call no are we getting rid of the second amendment no well then what do we know when what we know they pick out gun free zones that's one area maybe we can limit their if you're talking about red flag laws as Eric said yesterday with you know so many things that happen out there you might not even need red flag laws from what current law exist right now for many of these cases where you have had some of the mass shooters or whatever the the one eat even though the the kid did reported pulled a gun on someone will that's enough to do it a lot of the behavior already would keep you from owning a gun if that was found out but the last thing that we need to do last thing I want to do is be like them I don't have to.

Nicotine
"nicotine" Discussed on 760 KFMB Radio

760 KFMB Radio

03:57 min | 1 year ago

"nicotine" Discussed on 760 KFMB Radio

"Nicotine is an addictive chemical boulder show he is curly he has a morning off I'm hearing back from her I'm here and you're there so aboard chat to our last caller look I I understand your frustration it's been part of our frustration how the Republicans and and and even this administration of how they how they communicate a message and Republicans for the longest time not communicating a message effectively but you don't have to be deceitful when you don't have to say things you don't believe and you don't have to play dirty that's the beauty if you're a conservative you don't have to play dirty yeah I have to make stuff up and she said you know after the congressional shootings they should have gone in in right and and and blame right after the death the the the Democrats were to blame them specifically for just like they're doing to us and I told you the reason Republicans and get service don't do that is they don't believe it they understand that the you know in a society that you when you have you're going to have free speech and people are going to go over the top there always going over the top I understand it what happens in a Republic it's meant to be that way the whole system was set up so people can spew out the most vile rhetoric at each other and we don't know but if we don't end up for the most part in a civil war or people killing each other over the politics then you have the people that commit mass shootings but as I've said three hundred thirty million people in the country roughly five to ten of these type of specific crimes a year sometimes fewer they have increased and so most conservatives and Republicans look at it go you know terrible that these things happen what can we best do well are we going to change the way that society is not really are we getting rid of video games now I mentioned earlier begin your bird pot get rid of pot now call no are we getting rid of the second amendment no but then what do we know when what we know they pick out gun free zones that's one area maybe we can limit their but if you're talking about red flag laws as Eric said yesterday with you know so many things that happen out there you might not even need red flag laws from what current law exist right now for many of these cases where you have had some of the mass shooters or whatever the the one eat even though the the kid did reported pulled a gun on someone will that's enough to do it a lot of the behavior already would keep you from owning a gun if that was found out but the last thing that we need to do last thing I want to do is be like them I don't have to lie about Joe by I don't have to lie about any Democrat or any liberal all I have to do is tell the truth just get the truth out there and I understand how it's frustrating when you see the party.

Nicotine
"nicotine" Discussed on WCBS-FM 101.1

WCBS-FM 101.1

08:15 min | 1 year ago

"nicotine" Discussed on WCBS-FM 101.1

"Nicotine, nicotine is an addictive chemical. You. I don't know. Things. I don't know. Control. Someone to happen. About that. That. And. CBS. Pam were caller. Eleven grabs para. Tickets to go to a great.

Nicotine Pam CBS
"nicotine" Discussed on Ben Greenfield Fitness

Ben Greenfield Fitness

04:12 min | 2 years ago

"nicotine" Discussed on Ben Greenfield Fitness

"Of to SaaS, Ron, and estrogens nicotine can help with that as well. It has been studied and shown to be beneficial for treating Alzheimer's for treating Parkinson's and for treating to read syndrome, you know, three different neurodegenerative conditions. And for all those seems to act primarily upon what are called acetylcholine receptors. And so it's it's something that actually pairs quite well for similar reasons with any type of Nutro pick or smart drug it. It's very good to include in some of the stacks. Let's say Kuala l. brain or silk. Tap, none of those have nicotine in them, but you can literally just like us nicotine nicotine, gum, nicotine, spray, whatever, and have that same time as you have Nutro pic- or smart drug and seems to enhance the facts. It also acts to lower inflammation reduces t- NFL production and side king production. It can assist with patients who have inflammation due to ulcerative colitis as well. Although the caveat, there's you gene to be careful because a lot of these gums and lozenges they do have things like artificial sweeteners or or toxins or preservatives in it that could aggravate your if you already have a pre existing condition, especially. So he'd want to be kind of careful to choose pretty clean sources of nicotine if you were going to do something like that. And in addition to that, it's been shown to reduce pain. So people who are on nicotine score, they're paying much lower after surgery. It can be protective against all sort of colitis, like I mentioned, but also enhance the production of intestinal Miko said actually can increase the thickness of mucus in the colon. That's what slightly higher doses doses close to five milligrams, which could make you kind of jittery and be a be a, you know, like an incredible pick me up, but even smaller amounts it seems to have the same anti inflammatory effect. It can open weight loss and insulin control probably because it's a potent appetite suppressant like chewing on a on a little bit of nicotine. Gum is a potent appetite suppressant but also seems to be able to increase metabolism via what are called Molyneaux coordin- emcee for our receptors meaning you can actually see a little bit of bump up in metabolic rate because it has that angiogenesis potential. I talked about earlier if you have to, you'd want avoid it. But because it can increase growth of tissues and blood vessel capillaries, it can help with tissue repair. And you know, there's a few other benefits of nicotine, but I mean, the. The real big picture. Here's I'm fan of it. You have to be careful because it can be addicting. You need to be careful. You're young and you use it. It Paris quite well with a lot of other Nutro picks and smart drug like compounds in the show notes. If you go there, I'll put a link to the pixel teen nicotine toothpicks own and use really like the cinnamon flavor. For example, I had my personal assistant go through and kind of do like a spreadsheet analysis of which of the nicotine gums the lowest in preservatives or artifice, sweeteners, or chemicals. The brand Habitrol appears to be the best. And so all linked to that one in the show notes, and then there are also these nicotine lozenges. And again, same thing. A lot of these, these, these alot singers are losses have you to pronounce that they're really anybody say it that way? Yeah, vigor. They are losses pound. No, yeah, I'd say launches, but yeah, yes. So Nyquil and make. These ones that are really small. So they're almost like tiny little mints and they have less of the artificial sweeteners and preservatives in them. So for gum, Goethe Habitrol for lozenges. I'd go with Nyquil and then for toothpicks I like this brand called pixel teen, but all linked to that stuff in the show notes. Most of those, I think all of those you could grab off Amazon. So there you have it nicotine, you know, with a Asterix is healthy. I mean, throw in one little warning there. If you weren't a smoker, you haven't experimented with nicotine before go easy at first..

nicotine Nutro ulcerative colitis Goethe Habitrol Alzheimer acetylcholine SaaS Habitrol Parkinson NFL Ron Molyneaux coordin Amazon personal assistant Paris Miko
"nicotine" Discussed on Ben Greenfield Fitness

Ben Greenfield Fitness

02:34 min | 2 years ago

"nicotine" Discussed on Ben Greenfield Fitness

"They shown the same thing with marijuana and most of these studies, you're seeing these type of facts and anyone who is a user under about the age of. Twenty five. I didn't know near. I didn't go near nicotine at all until what's wrong with me. Thirty six. I didn't touch marijuana because I was well aware of its its its ability to affect gray matter and Coug Nishit cetera. I was I think, thirty two when when I first went near marijuana, I could say the same thing for alcohol and liver formation prior to the age of about eighteen. So there are certain situations in which you just wanna wait until you're grown up to some of the stuff. When did you when did you wait to lose your card? My v card. My virginity. Yeah. Like thirty seven. No, I was. I was fifteen, but I can also proudly say that my wife and I actually waited until we got married to have sucks. I'm proud of that because I was very hard to do madly in love. We just wanted to be special. We're so yeah. So we waited school. We went at yet world school where we're. Chris fundamentalist Puritans. Yeah. So anyway, back to nicotine back to nicotine. So nicotine increases wakefulness motivation, alertness, creativity. It's been shown to increase activity cross both hemispheres of the brain. So in folks who like Microsoft LSD, you can actually get some of the same type of water called bilateral neoclassical activation 's via the use of nicotine and also increases your alphabrain wave state. So you get better attention, better, creativity. If you're an athlete, you're better able to enter into the zone. In addition to that, it has been studied and proven to improve your fine motor skills and also your short term memory, your long term memory and what's called your working memory. So it can actually improve your -bility to multitask, which is very interesting and significantly helpful. I think for a lot of people, it's been shown to help with ADHD. ADD symptoms. Axes, a neuro protective Meniat can reduce inflammation in the brain stimulates what are called Cohen, urgent receptors in the brain. And by doing that, it connect as neuro protective, but also via similar pathway blocks estrogen so has anti-oestrogen effects, which is also important. You know, especially for, you know, for example, men who want to have more free testosterone availability unless aromas Asian.

nicotine marijuana Coug Nishit testosterone Microsoft Cohen LSD
"nicotine" Discussed on Ben Greenfield Fitness

Ben Greenfield Fitness

02:29 min | 2 years ago

"nicotine" Discussed on Ben Greenfield Fitness

"So before it's not a Touma. Yeah, before filling you in on this, I should note to that. I probably consume close to three to four milligrams of nicotine a day, whether via nicotine lozenges dissolved in the mouth pre-workout, which I absolutely love nicotine gum. I chew on Cotin gum usually couple pieces day, and then you'll occasionally find me like if I'm out at dinner and it's like late dinner and I wanna be up like all times like nicotine toothpick sticking on my mouth. I also a big fan of writing in my book with the nicotine toothpick and a Cup of coffee writers. Best friend. That's a great one. Two combo. You feel bad ass with big black Cup of coffee and nicotine toothpick hanging at the corner of your mouth. Just a good look at is a good look. That's very dirty. Harry of you. Yeah. Yeah. I'm all dirty. Harry use the nicotine, spray it all that don't like thing. No, I don't use a spray. I know what you're talking about. I don't. I don't. It's it's valuable for sale in Canada. You can't even buy in US. Oh, yeah, that's right. It's a, yeah, yeah, Canadian, I mean invent yeah, it's and it's not impossible to get have Canadian friends. I could get import, I just don't, you know. So he's liking fractions, your breath while you're, you're getting your hidden nicotine, you becoming addicted to nicotine of wonderful breath. That is something that that I should note before I get into the benefits, do need to be careful. Nicotine is addictive and just like when you try to quit smoking cigarettes when you try to quit nicotine and get strong, cravings increased appetite. And so. Sleep disturbances and a little bit of Iran ability and restlessness. But I think that if you use it in moderation and you're already aware that it could be addictive like me. I limit my use because I'm aware of the potential. So I'm just careful with it. Like I mentioned, you'd want to be careful because it could be an NGO genyk type of substance if you already have a tumor. And then there is some evidence that for adolescent users like in people this same reason like I don't let my kids smoke weed and dishes into the fact. It would enor- my wife and my kids don't like weed or the smell of it. It could impair the prefrontal cortex in adolescent users. And when you impair the free prefrontal cortex, you've course limit cognitive performance and they've shown the nicotine use during adolescence in studies can increase the risk of cognitive impairment later in life..

nicotine Canada Harry Touma Sleep disturbances Iran
"nicotine" Discussed on Ben Greenfield Fitness

Ben Greenfield Fitness

02:13 min | 2 years ago

"nicotine" Discussed on Ben Greenfield Fitness

"And when you have a glass of water, like put one and a half or two grams into the water, preferably warm start up and drink at that way rather than taking all your creating at once like in the morning or pre-workout haven gave here in the last year. So again from smoking cigarettes to ping to snuff touches, and then. MAURICE Lee have discovered this stuff called z. y. on which is non tobacco nicotine patches. And I was wondering what your thoughts were on them and what your thoughts were on nicotine in general other, it's all guttural dead when used in not used. Thanks. I think I need to go take a big, drag my cigarette imply use moving parliaments. Do you make a cigarette? Sound effect able to do that along with your bird, but could you hear that pretty good? That's pretty me. Br blowing smoke ring. I like that. I like that. Well cigarettes, we've course no have been proven time and time again to be. And yawn. With a cowboy hat after sex. If you wanna sexy, everybody has a sack of cigarettes around the keep you lean. But contrary to opinion, because of been thrown under the bus along with cigarettes, nicotine is not carcinogenic substance. I should note that if you already have a tumor there, some evidence that nicotine may actually play a role in angiogenesis to tumors, meaning. Like if you already have a tumor is probably not a good idea to be using nicotine. If you have cancer, don't rush out to buy Habitrol gum. The same could be said, for example, for protein, right? Like I'm a huge fan of protein for its anabolic benefits. It's appetite satiated benefits, the fact that the amino acids and can act as neurotransmitter precursors. But if I already had a tumor, I would eat very, very low amounts of protein because it could allow for for tumor growth. But I mean with nicotine less, you already have. Tumor. It's not carcinogenic in the least, and it actually has a lot of really good things going for it that I can fill you on right now..

nicotine MAURICE Lee cancer two grams
"nicotine" Discussed on Bulletproof Radio

Bulletproof Radio

01:39 min | 2 years ago

"nicotine" Discussed on Bulletproof Radio

"Either hide under desk or hit people well it's not at all like nicotine that's for sure but if you had adhd you see which i did what which you you might find is the stimulants may actually improve your ability to inhibit you know inappropriate impulses or or improve your ability essentially to be on task for example so it really depends i always always try to explain this to people that the effect of any drug that has this sort of bidirectional effect is really dependent on where you start so we can show even in rats if you buy one hundred white rats from a supplier and you give them nicotine you'll find some of them will really get a better cognitive performance some of them will get worse wow and it really depends on which that we're those animals started so the ones that perform really well without nicotine will get worse with nicotine and the ones that are poor performers will show improvements that leads to a really important question for people listening to the show there are a lot of people who think they're really good performers but aren't performing at the level they're capable of there are a lot of people who are good performance performing at their limit and there are people who know they're not performing at their capability set how would you know if you're one of those people for whom nicotine might be a useful substance well i mean that's a that's a tough one i'm not sure that we.

nicotine
"nicotine" Discussed on Bulletproof Radio

Bulletproof Radio

02:03 min | 2 years ago

"nicotine" Discussed on Bulletproof Radio

"It might be in a real world test so we could say okay if we got this degree of improvement in this particular task in the lab which is called the stop signal task which is a measure of how quickly you can stop a response a pre potent response that actually mapped on pretty well to how well the drug would work in a clinical trial so we began to realize that there are some people out there who really benefit from tuning their brain a little bit this way maybe they just wanna be you know so many of us if we have depression for example or mood disturbances or anxiety right we might benefit from tilting us just slightly to the right or the left and that's what nicotine may do and so for example if you know we always used to joke around our lab that nicotine in some respects is the perfect psychotropic drug because if you're deorala it will arouse you if you're over aroused or hyper aroused it will calm you down right so it will bring you more into sort of that middle ground right so the guy in the movie who's gonna be executed and they offer emma last cigarette right right i mean there's a reason there because it's anxiety lick it's antianxiety it reduces anxiety but if you're derived it may actually wake you up now that's different from 'em phetamine do that won't do that i'm fed amine has kind of linear uni directional effect right it just simply flog your dopamine noradrenaline receptors until you basically run out of transmitter and so that doesn't really tune the system very well my limited experience with with amphetamine as a prescription and in business goes that it made me wanna.

nicotine emma amphetamine dopamine
"nicotine" Discussed on Bulletproof Radio

Bulletproof Radio

02:10 min | 2 years ago

"nicotine" Discussed on Bulletproof Radio

"Oh brain for example it turned out that the one that we designed didn't do that but you know we learned from those mistakes and we say okay now we we should design something a little bit different and you're right we should look at other outcomes and so if we do this study again which we're hoping to get funded to do we will look at brain circuitry and we will look at other outcome measures that might be proxies for the eventual target i do a thanks because back in nineteen eighty eight at you were the first person to propose augmenting the nicotinic system to treat alzheimer's disease and i've come across a few of your papers and i'm a relatively outspoken fan of nicotine as apart from tobacco and smoking which have clear is but but nicotine is a as a pure fide agent seems to be a really potent cognitive enhancer for at least a set of people including me and probably even has some health benefits depending on which benefits you're looking at even though there might be other counteracting things what made you look at these pathways or look at nicotinism medical therapy so early on well you know it's like it's like everything else it's a little bit serendipity i came into a lab at nih wear people were looking at culinary gic drugs and i looked around and i said well what's no one else looking at and i said well i seem to remember for medical school that nicotine activates the same system why don't i look at that and in those days there was no patch there was no gum there was no spray or vape or anything like that so we had to actually make our own nicotine for intravenous use we infuse it and we had to basically create our own pharmaceutical which we did it and i h with the help of some very clever pharmacists and we actually created an intravenous formulation of nicotine that we could.

nicotine alzheimer's disease nih
"nicotine" Discussed on Bulletproof Radio

Bulletproof Radio

02:02 min | 2 years ago

"nicotine" Discussed on Bulletproof Radio

"As a neuroscience facility where we're doing at twenty four channel q eeg brain scans and five days of intensive neuro feedback where we can see yes do these circuits are active in these areas over connecting and these areas may be our only overactive in one frequency band and they're underactive in another if you're looking at it from electrical perspective and it gets it gets very easy to look at something and say could you draw a line between bad performing highperforming would not be a straight line it's like a fuzzy swath and if one goes up something else doesn't go down it's not gonna work and i'm i'm really happy that you're the explaining that because right even even the real simple cognitive enhancer things like caffeine nicotine that that have been relatively well studied for the long periods of time like you said sometimes they do good things but sometimes they don't do good things and even figuring out how they do good things is really interesting and we're still kind of at the beginning of that so i just wrote her proposal a few weeks ago which just went in last week to to look at a novel molecule that we've developed here at vanderbilt that we believe will be cognitively enhancing and this and the way we wanna look at this impatience we've already got this molecule into humans now in our phase one study but we want to actually test this patients and and we wanna take a totally new approach to testing it which is not to use the same old approach we've done before but actually to use brain networks as a measure of of what we call targeting gauge ment we want to show that we can actually change the relative activity and connectivity of these well understood or well reasonably well understood brain networks because that to be honest.

nicotine vanderbilt caffeine five days
"nicotine" Discussed on Bulletproof Radio

Bulletproof Radio

02:20 min | 2 years ago

"nicotine" Discussed on Bulletproof Radio

"Or or some kind of imaging wouldn't most people have some areas of their brain that are underactive or overactive or not working very well i think the answer is if it's if you're saying most people i think the answer is probably no interesting so activity in the brain is not a linear construct or yeah so more activity is not necessarily better and less activities not necessarily worse and one of the things we're learning about this actually this turns out to be really interesting is that if there's a drug that enhances cognitive performance let's say in an alzheimer's patient it may increase activity in areas that you want to be active for it but to get our task what say but it may actually decrease activity in a different network that we see typically overactive in patient so for example one of the things we showed in patients are in a review paper that we published a few years ago where we looked at nicotine affects on brain activity the data seem to suggest that that a culinary drug for example might increase task relevant areas in the brain but it might actually decrease activity or decreased connectivity and now we're talking a lot more about connectivity than just activity it might decrease connectivity to is that are less valuable or or you don't wanna be activated me one of the things we know about the brain as it changes with both the normal aging and with disease is the start getting over activation of a lot of areas that aren't used in younger ages or in air or in patients without pathology now that may be compensatory in some sense but that comes at a cost so it's so that what i'm trying to say i'm sorry i'm going on about this but it is really just not a linear construct you can't say oh i need to increase the activity of these areas my brain may actually be better for you if you decrease that is a fantastic explanation and one of the one of the projects that i'm involved with is.

alzheimer nicotine