22 Burst results for "neurodegenerative disease"

"neurodegenerative disease" Discussed on Breaking Biotech

Breaking Biotech

03:49 min | 6 d ago

"neurodegenerative disease" Discussed on Breaking Biotech

"So i think it's worth it to kind of hold onto the star. They're also looking at alzheimer's disease vascular pathology and they're going to initiate fees to trial in the middle of this year. So that's going to be the more impactful readout. Unfortunately we're gonna have to wait quite a while before we see any data from that. So that's on what i wanted to do before we wrap up is really compare these companies and how far they are in their trials so if we look here at the market caps that have outlined i also have their net current cash as of around february twenty twenty one not all these companies have updates for q four. So this is my best estimate. And what we can calculate. Based off of this is the enterprise value and what this is really a value of the company itself and how much it would cost if you were to try and acquire one of these companies and the equation is market cap minus cash plus debt or liabilities. And so i've done that here and we look at that. We can see that cortex. I'm anna vex and elector are all trading around a similar enterprise value. And i think that's appropriate given their all in relatively similar spot in terms of clinical development. We coretec simon annex. That are going to give phase to be three updates in kind of the end. Twenty twenty one or the beginning of twenty twenty two and then electoral is going to give updates as to twenty twenty one. But they're phase three has already started as of last year. So we might see an interim read out that could really provide some insight into whether or not the molecule has any hope. So i think for this reason. It's interesting for us to look at that. Because i would be willing to take a position at any of these companies in anticipation of that positive readout given that the upside might be ten billion dollars and the downside is probably cash on hand so keep in mind that some of these companies might have to raise money before. They're actually gonna get to that readout. So it's for that reason that i want to.

anna vex last year ten billion dollars one middle of this year three updates around february twenty twenty Twenty twenty twenty one phase three twenty twenty two q four twenty
"neurodegenerative disease" Discussed on Breaking Biotech

Breaking Biotech

04:56 min | 6 d ago

"neurodegenerative disease" Discussed on Breaking Biotech

"Three trial they started this in july of twenty twenty and according to the nc t site their estimated primary completion date is october twenty twenty three but there is potential here for an interim row. Now we don't really know when that's going to be but presumably they're going to fill this catalyst somewhere where there's kind of a lag so i would expect maybe late twenty twenty one or early twenty twenty two. They're going to give us some insight into how that phase three is going with regards to ails user. Three day are in phase one b. And they're planning on releasing some data from healthy volunteers in this year. So i don't really like when companies are very broad when they say just the entire year is when they're going to release the data but i think as we get through their earnings reports. They're probably gonna give us a little more granularity on that. So let's get to say clear on and say clearing on traded on friday the nineteenth at four dollars and forty cents a share giving them a market cap of one hundred and forty million dollars. They're cute three twenty. Twenty net loss was nineteen million with q. Three twenty twenty current assets seventy million and q. three twenty twenty current liabilities. A sixteen million and mostly clear on is doing is they're commercializing. A modulator soluble And the hope is that modulating. This molecule will increase cyclic. Gnp and for those. That are no cyclic. Gnp is a very important molecule. That's involved in a number of different effects on cells. One of the most notable ones its effect on vase. Oh dilation and so. The company has tried to use different molecules to take advantage of this in order to try and get approvals in different indications. Now for them that they have failed. In a number of indications their most recent one is sickle cell disease and they gave that update in q. Four of last year. When i originally took my position so the company has done is. They've refocused on the one molecule that showed some you know good data kinda mix data which was see why six four six three and this is a blood brain barrier permeable molecule and. They're looking in different kind of neurodegenerative diseases. The top one is meal us and then they're also looking at alzheimer's disease. Vascular pathology and minna. Show some of that early data. They announced to us in q. Four of last year so what they told us is that treatment in healthy. Volunteers led to an improvement in alpha power as well as end two hundred latency and to evaluate. This is they did. Hugh eeg measurements on patients. And this stands for quantitative electro encephalopathy. And what this does is measured brain electrical activity and so there's different wavelengths at which the brain is able to signal and this can be measured using this technique so alpha power in particular is apparently important for things like passive wakefulness attention and cognitive processing. And in general alpha power declines with age. And it's exacerbated in neurodegenerative diseases so treatment for fifteen days with this molecule lead to an improvement in alpha.

nineteen million seventy million sixteen million friday fifteen days last year late twenty twenty one four dollars october twenty twenty three early twenty twenty two Hugh eeg july of twenty twenty Three forty cents One one hundred and forty million one two hundred q. Three twenty twenty this year
"neurodegenerative disease" Discussed on Breaking Biotech

Breaking Biotech

05:50 min | 6 d ago

"neurodegenerative disease" Discussed on Breaking Biotech

"Lincoln the description below so excited to be back. And i've got a great show for everybody today. We're gonna be talking about companies that are involved in the neuro generation space. And the reason why i wanted to do this is that some companies saw a huge increase in their stock price. After cassava scientists released their updated data on their alzheimer's asset. And i thought it would be useful for us to look at other companies in the space to get more broad brush on the landscape of neuro degenerative diseases and see whether or not some company stand out as better or worse investments. So today we're gonna talk about cortex sign annex. Scientists elector cycling on. And we're gonna touch a little bit on cassava scientists. And before i get into the show i did want to mention that. I'm going to be doing an ask me anything on the sub reddit. Biotek plays so. Check out that sub. Reddit there's actually really nice community there. People who are interested in the biotech sector and they've just reached ten thousand subscribers. So check that out and input your questions on a spreadsheet. That's over there. And i'll do my best to answer them. I think it starts at one pm at pacific standard time and with. Let's just get right into the show. And before i get into the actual companies involved in the space. I did want to talk about the potential total addressable market. And it's important that we start off with this and i'm not going to belabor the slide too much 'cause i did touch on it last time but we want to know is the potential revenue company could garner if their asset went all the way through the clinical process and finally got approved and marketed. So that patients could actually reach the drug. The best way for us to do this in my opinion is to look at a previously approved drug. That looked similar indication and one. That's great for the alzheimer's market is one called. The generic name is dan episode and this drug was a wild success. It treats the symptoms associated with alzheimer's disease but it doesn't actually change the course of disease progression and what we can do is look at the pricing air set. Multiply that by the total number of alzheimer's disease patients in the usa. And then we come up with a total potential addressable market. That drug..

Lincoln Biotek usa reddit Reddit ten thousand subscribers today one pm one episode
How the gut protects the brain from infection

The Naked Scientists

05:10 min | 4 months ago

How the gut protects the brain from infection

"A brains sit cocooned inside a series of protective layers. They called them in injuries. And these together with a structure called the blood brain barrier keep out unwanted bugs nasties that could otherwise prove lethal forest. But how exactly the brains defense systems do. This wasn't known now. A new discovery is added an important piece to the puzzle specialized plasma cells these a blood cells that make antibodies is important potentially harmful bacteria in our intestines and then make their way up to the outer part of them in indies called the juror where they churn out antibodies and keep the brain bug free medical worthy. The thing that really got me interested in thinking about the brain is that there's increasing evidence that the immune system plays a role in a number of brain disorders so things like depression and anxiety and even the progression of neurodegenerative diseases like parkinson's disease as well as that. We know that the immune system is required to defend parts of the body from infection. So this could be important for defense against infections in the brain and in the ninja. So things like meningitis. How did you them. Pursue this to try and work out. How the brain was actually fending off infections. As with many studies in immunology we use mousers as a model and so the first thing that we did was to take meninges and look at them under the microscope and they were plasma cells in the sierra and they were not just got anywhere. They are actually lined up along. The border of large blood vessels that run through the zero. The these bug vessels are called venus. Sinuses the next question. When we find these plasma cells was empty they were producing to all surprise. We found that rather than producing igt. What's normally find in the body. They were actually producing an antibody. That's normally found gut so you've got this interesting observation an- tomic clear in the first instance of blood vessels running through. Jeez they've got cells that make antibody lining up along them. But the antibody they're making is one that you would not normally associate with the bloodstream. It's one that you would find in the testing. Yes so that was surprising. And i guess the next question was well duty cells actually originating the guts or are they influenced by the gut so to answer that we were able to use. Mice have never seen any sort of bug. They have no bacteria or any microbes in their intestine and when we looked at the dura from these animals they were no cells whatsoever but when we added bacteria back into their gut suddenly again the antibody producing cells reappeared in the era and even if we only eat put one type of bacteria into these mice a type of bacteria that couldn't go anywhere other than the gut we still saw the cells reappear in in the dearest that told us that those cells originated in the intestine. Your sort of hypothesis is the bacteria in the intestine. They educate the immune system and immune cells the intestine and what the cells then migrate from the intesting with the knowledge of how to make antibodies against those specific microbes. Up to the brain and take up residence in the meninges around the brain exactly and they specifically take up residence at the border of these d'oro venus sinuses. And i guess then the obvious question will why. Why would that happen. Why is the system being set up and the obvious answer would be. Maybe those cells there to protect The brain from microbes bacteria that originated in the gut into the bloodstream. When they're flowing through those at venus sinuses where blood flow is quite slow. It's an opportunity for the bugs to get out into the brain so to test that what we did was to remove all of the antibody producing cells and then we challenged mice with microbes into their bloodstream. And what we found was the bugs were able to get a cross into the brain as so it told us that really. We found a whole new defense system for the brain. What are you going to do next. We're interested in the signals. That might take the plasma cells from the gut to them. And jeez and then the other thing. I'm really interested in is whether this has implications for how we try and protect people from meningitis at the moment. If we vaccinated against meningitis we give that vaccine into the muscle but our study would suggest that actually if you want to make cells to defend the brain the route that you should give that vaccine is actually via the gut and so that's something that we look into the bodies a clever all thing. Isn't it minute klatt worthy there. She's basically comes university. Study describing that work has just come out in the journal nature.

Parkinson's Disease Meningitis Indies Anxiety Depression Klatt Nature
"neurodegenerative disease" Discussed on Collective Insights

Collective Insights

05:32 min | 8 months ago

"neurodegenerative disease" Discussed on Collective Insights

"What are all the things we can do as you and I? I have talked about before the armaments Barium for this disease. We've been told zero. In fact, the armaments is massive, and it has to do with lifestyle, and it has to do with Diet, and it has to do with stress, and it has to do with brain train, and it has to do with drugs, and it has to do with hormones, trophy, factors, and supplements, and on and on and on, and you have to know how to use it optimally for each person, which starts of course with understanding why they got to where they are. So you're right with respect to the Diet. People are studying all sorts of things. And again as you indicated earlier, there are things that are not mutually exclusive. People will say Oh, it's all about Mediterranean diet well. Yes, that that could be helpful. What has been found though is that people? Who have cognitive decline associated with Alzheimer's or pre Alzheimer's? Do have a decrease in glucose utilization in their temporal and parietal Corsie's. And specifically they often show in the in the pre cuny us and post terriers single at this picked up on pet scans. So how do we bridge that gap? And of course one of the best ways to bridge that gap, and yes, originally, it was thought. Yeah, they just have degeneration, so they're fewer mouths to feed its turned out not to be that simple in. In fact you can improve that energy gap by supplying key tones, and the now we all like ult- for the long run. We like to see Endogenous Chitose. But in fact, there's a nice publication showing you can simply take people like this. Give them whether it's exigent or endogenous, and it will help them, so they really do have an energy emergency so when you see. See People. Yes, in the long run, we want to get them to Ha- to produce key tones and dodge Nestle because there are some advantages to that such as things like anti inflammatory effects, but in the short run and I have this argument with my wife was an integrative all the time because she really believes that the first thing you're going to do, is you want. Want to make them insulin sensitive and I say no. Their brains are starving. We have to get them rescued with key tones on day one then we can work with them then we can help, and we know from the publications and of course Mary. Newport started all this with her own husband years ago. Saying I can give him this now again if you just give. Key tones. They're all sorts of us. There are all sorts of. Gives that that you won't get ultimately within dodge so for example. You are. You're not allowing them to generate their own key tones..

Alzheimer Ha dodge Nestle Newport Corsie Mary
"neurodegenerative disease" Discussed on Collective Insights

Collective Insights

06:00 min | 8 months ago

"neurodegenerative disease" Discussed on Collective Insights

"Hacking these various parameters than no surprise. Your brain needs to go into protective mode. You are doing something very different, and in fact, you're APP recognized that you can literally trace the bleecker pathways to AP cleavage, and here's an example when you have ongoing inflammation and F. Cap be activated that turns on a whole set of genes, and among those is the Beta secret taste and the gamma seeker tastes that make a Beta the amyloid that we associated with Alzheimer's disease. Disease so this the problem is that amyloid. Yes, when you pour amyloid all over neurons, no surprise. They don't do well, but you have to look at. Why is your brain making the amyloid? Well? It's making it because of the ongoing signaling because it's been invaded because it's been insulted so the idea that you adjust say we're going to take away the stuff that responds to the insults without taking away. The insults is absurdly simplistic and no surprise when you take it away. Away many people actually get worse because you're now taking away a protected this stuff as anti microbial as rudy. Tanzi is shown in the past, and and his colleagues Robert Lawyer, and their colleagues published repeatedly. This stuff is actually anti microbial. As Ashley Bush has published, it also binds metals. So this thing is there. Yes, it is downsizing. It's a little bit like again like if if you have a president, who says you know we're going to have to downsizing? We're going to. To have to tighten our belts, and so, what do you do? You say I don't want tight. My Belt I'M GONNA kill the president. That really doesn't help you. You're still going to have to tighten your belt at some point, and so that's what's happening with a P. signaling, so we want to go upstream. We want to look back at look at the big picture. What is Alzheimer's? It is a response to all of these different insults. We need to identify them. Identify the ongoing pathophysiology and address that instead of trying to get rid of a mediator be at Tau, be at amyloid bid, reactive oxygen species. Be It iron. Be You know all people have tried to get rid of all these different things? You know why don't add oxidants. Isn't that the way to treat? Alzheimer's and then of course recently, people say well. It's all about herpes well. Yes, in some cases it is, or it's all about mercury. Well, in some cases it is, but these things all our contributors, and they're going to be a little different for each person, so you need to identify them and address them, and as you know when you do that, that's. That's when you get the best outcomes now. The most interesting things to me are the people who respond extremely well where just everything just melts away, and they do great, and on the other hand the people where you do everything right, and somehow they don't respond and we need. Those are the ones that there's something missing. We need to understand. Do these people need stem cells? Have they lost too synapses do they have? Have ongoing inflammation. Is there something genetically one of the interesting things that's coming up right now?.

Alzheimer president Alzheimer's disease Disease Tanzi Ashley Bush Robert Lawyer
"neurodegenerative disease" Discussed on Collective Insights

Collective Insights

03:19 min | 8 months ago

"neurodegenerative disease" Discussed on Collective Insights

"Without further ado, let's jump into the show. Here's Dr. Sandison and Dr Bread isn welcome to collective insights. I'm your host today Dr Heather Sandison and I am so pleased to be joined by Dr Del Reticent Today Inkster, being on the show. Thank, you heather! Thanks for having me. So you and I both have some research going on in our perspective quote, Unquote last in my clinic and your group. Why are these studies so important to the field of timers and Dementieva's? Well as you know, this has been the area of greatest biomedical therapeutic failure. So as they say, everyone knows a cancer survivor. No one knows an Alzheimer's survivor. Although now we have hundreds of them, but this has been the area where whether it's LS, whether it's frontal temporal dementia, Lewy body disease whether it's Alzheimer's disease. We just as a standard of CARE medical system. We have not had anything to offer people..

Dr Heather Sandison Dr Del Reticent Today Inkster Dr Bread Alzheimer's disease Alzheimer Dementieva cancer Unquote
Collaborating to Cure Dementia

Sounds of Science

08:35 min | 10 months ago

Collaborating to Cure Dementia

"Many of us will have to deal with dementia at some point in our lives whether as a patient or caregiver this terrible range of conditions affects five to eight percent of the sixty and older population at any given time. According to the World Health Organization the Dementia Consortium of Private Charity Partnership that Charles River joined last year is one of the organizations leading promising research on dementia treatments in order to discuss this condition and the research to treat it. I am joined by Sarah Almond Associate Director of integrated biology. Welcome Sarah Hi. Can you explain the purpose and organization of the DEMENTIA CONSORTIUM DEMENTIA Is SETUP BOY A? K. or outside research she k. Is a charity that focuses on. Alzheimer's disease it brings together. Active research is Pharma partners. Sarah's including Chelsea River in order to bring forward novel treatments dementia including outlines disease outside reset she. Kabc this research is invited to come forward with ideas for novel targets in Europe. Degeneration Your Inflammation Way. Them work with them to put together. What packages the funded by the partners? Anti Kate to prosecute he's talk and hopefully lead to novel treatments for Dementia. What do you think of the way? They've set up their organization. I think this is a great way to stop the organization because it brings together such a broad range of experience From academic researchers may have spent years really understanding the biology of targets to pharmaceutical companies. That know how to bring targets three two treatments actually effective in the clinic and also is a CRI where we have a broad range of so biology and chemistry capability so we cannot provide the word packages also have extremely experienced. Research is catchy. Help develop the molecules to treat these young coupled with the charitable input of the Vale Uk. He Project managed but also do so much to bring forward research in this area. Yeah absolutely cut covering all the bases. So what is Charles Rivers role in this group? You mentioned a little bit and you go into a little more detail. Charleston is WANNA to Communist with capabilities and drug discovery expertise. We provide strategic input into plans to de risk these targets and how to generate tool molecule suitable testing the hypothesis. We went with Alzheimer's Research K. And the principal investigator to proposals together. That income dreams that executed by then the appeal and US working closely together. They may do the basics. Hogging island allergy and we bring medicinal chemistry or HD CAPABILITIES. That actually will enable us to find a joke against that tailgate. We meet with the foul partners to finalize plans. And then once funded. We actually execute the work. Okay awesome I understand that a couple of research projects from the consortium have already been green lit Can you explain those proposals? She'll you're correct to Russia in progress of the two targets. One is fine as the Scott appears to link to Tau Accumulation ear inflammation. We aren't sure whether we need to be selective over a closely related kind as the. Pi is looking at whether ACHSAF. You've reduced this target. That doesn't indeed impact Taufel are. They should be China in Vivo. Mostly of onto molecule and vacation and which is a specific type of dementia or Alzheimer's. Or is that just a general Assignments towel face but particularly Alzheimer's disease at the eventual Gulf one is to the impact of the tour the killer produce on time phosphorylation. In an in Vivo model than the second project is two gene mutation I l s from tempo dementia the courses of pathogenic Rene to be produced. And we're aiming to block the expo this RNA. By targeting his with the protein takes out the Chris into the cell. When this new mix and Rene is exploited toxic repeat protein produced which then up today so responses and Kohl's neurodegenerative disease so the talk if allegations. This is actually already fairly strong. So we'll focus on producing told molecule capable of testing the hypothesis drug ability in Viva. And this is quite interesting that uses Zebra Fish Assay which is as a Pi Out Annika's scrap. The compounds can reduce the interaction between the protein. And the mutant. Aren a over So vice projects Charles River going to rub in Asia screen and then performed medicinal chemistry. Touchy try and get the molecules to kind of test with the viable targets. So how exactly is the consortium supporting this work on on these two proposals? So the consortium consists of Pharma Partners K. And they weren't. She formed kind of equal partners within that and they provide funding the project so they've also provided their expertise in kind of defining the key risks that we need to address in our plans and also technically hurt entice for example as I was research to see progress against small Stein's out payroll Consult here as a whole. I understand our work on dementia has increased substantially over the last year or. So is this because of a higher demand for treatment or is it more promising research avenues. Or is it both. I think by This been advances in understanding of neurons. Lemay tion in particular so this is triggered research projects. But also there's a shift away from the amyloid focused approaches for outside disease due to a lack of clinical success but equally dementia is still highly prevalent in and loss of US. Know people that'd be personally affected by this August. Just it's very hard Eric Tree but not one which people are going to give them. What is the importance of collaboration for researching these neurological diseases? They understand that. Probably the REAL STRENGTH OF THE CONSORTIUM. I think just touches found that there are Kiama nays area The SIS for those lost focus hasn't been successful in the clinic so it's clear that novel therapeutic approaches and needed and this takes time so rarely. We need different people to work together. Different functions work together so farmer actually reduce what they do in house and choose to those complex in return. Viva studies take years to fully establish in Zeros and so when academic academia follow charities and see arose all have complementary skill sets the they they research can be three to benefit the patient in the minimum time possible. Is it also a matter of the fact that CNN diseases are so complicated? And there's so many different factors going into the Mike. No one can be an expert in enough of the different areas of research to really do absolves ex exactly not. Yeah you know. And and so just by the nature of scientific institution you may get more time to focus on specific disease mechanisms. That PHARMACEUTICAL COMPANY. Just doesn't have the kind of time to dedicate starved to really building that level understanding but they may have a much broader range of complex models. That can actually help advance. This yet come has been unfortunately so we can you tell me about the psychiatry consortium which I guess is kind of an offshoot of the dementia consortium. Yeah it's it's basically has the same structures dimensions. Timonen is formed in consultation with a K. Who a kind of had a stake in his on. Psychiatry example schizophrenia or autism and this is obscene medicines discovery cats who are not for profit and are there the cats ponant which was set innovate UK to support innovation and use by UK business? So the psychiatry console is one of the indicates which is accelerating drug discovery and psychiatric

Dementia Dementia Consortium Dementia Consortium Of Private Alzheimer's Disease Alzheimer Charles River United States Rene Sarah Hi Sarah Almond Associate Director Of Integrat World Health Organization Europe Chelsea River Charleston Neurodegenerative Disease Vale Uk Russia Charles Rivers
Brain discovery could have important implications for neurodegenerative diseases

Innovation Now

00:56 sec | 11 months ago

Brain discovery could have important implications for neurodegenerative diseases

"From sixteen different countries are combining their talents with a team at the University of Virginia to investigate a two part system. That is a type of brain cleaning to fight diseases. Such as Multiple Sclerosis Parkinson's Alzheimer's stroke and dementia. The cerebrospinal fluid surrounding the brain serves as the immune system's highway for toxin and plaque removal. The UVA team is researching a slow release Gel. That can be put on the head like shampoo to enhance lymphatic function clearing the roads for medication to pass through the second part of the therapy. Introduces a substance into the body that induces an immune response producing antibodies. That helped clean out the sticky brain plaque. We can't yet cure Alzheimer's but we may soon see a day when restoring memories is just a shampoo away

Alzheimer University Of Virginia
"neurodegenerative disease" Discussed on The Peter Attia Drive

The Peter Attia Drive

02:09 min | 1 year ago

"neurodegenerative disease" Discussed on The Peter Attia Drive

"What is this person's risk of cancer. What is this person's risk of neurodegenerative disease so as you marched down those things you'd say well cardiovascular disease largely driven by three things like the proteins inflammation and failed dysfunction. How much of that can we see in blood actually a lot on the like protein side. We can see most of what what we want. Which is the l. p. Lay the l._d._l. The small l._d._l. I'm talking particle number. Not cholesterol and v. l. is alluded to on the inflammation side and we can see specific and nonspecific markers of inflammation. When the nonspecific side we can see things like fiber anogen- c reactive protein on the specific side. You can see things like ox l._d._l. L. l. p. p. l. a. to ox phospholipids. Those things very helpful. Endothelial health is the hardest thing to see but i include insulin here because i think that insulin excellent is in and of itself actually toxic at high levels to the endothelium and james o'keefe just recently was on a paper that looked at cardiovascular health in patients with type one diabetes so that they were able to actually use the insulin doses that people were using as a way to actually assess the impact on the i can't remember it was myocardium cardiac endothelium. You can look at things like home. Assisting we also look at something called asymmetric di methyl arginine or a._d._m._a. Sti which are inhibitors of nitric oxide isn't they so the way i tell patients is the younger you are the more your blood tells me about your risk of cardiovascular disease so a forty year old person who otherwise doesn't in have like some dramatic l. p. lay through the roof or something crazy. The blood tells me probably eighty eighty five percent of what i need to know the older a patient gets the the more i would probably rely on things like c. T. angiogram or even usually by the time they're older calcium score becomes less relevant. Calcium score can be somewhat helpful in a younger patient though it you know the latest study i saw which actually just was an editorial that came out two days ago based on a study in one of the atherosclerosis journals. Was you know looking at fifty percents of patients that had lee that had events had them at the site of non calcified lesions not a huge vote of confidence for how why alot calcium score.

neurodegenerative disease L. l. p. p. l. james o'keefe atherosclerosis diabetes lee c. T. eighty eighty five percent forty year two days
"neurodegenerative disease" Discussed on Mark Bell's Power Project

Mark Bell's Power Project

02:14 min | 1 year ago

"neurodegenerative disease" Discussed on Mark Bell's Power Project

"With the neurodegenerative disease, then it'll help you with the normal with the normal brain chemistry, even enhance those skills because it works. It's proven to work with them. It reverses the symptoms, it slows it down. So I pull a lot of that stuff from from my work. With the Parkinson's. Where'd you get some, the because I when you mentioned you know, the stacking the pennies, I've never heard of that before. So, like, where did you get some of these principles and ideas, did you learn from someone, or how'd you come about it a lot of it is? I like takes creativity. Like you, you know, fine motor skills are, are using all your fingers. Like, okay. So how can we? How can we translate that into an exercise? So a lot of it is I what is the research show? Well, they don't really go into detail what they're actually doing, but they go into detail a what the the symptoms are the reduce. Okay. So let's stack pennies, let's see if that works. Okay. That did it. Sometimes I'll, I'll suspend a, a ten pound weight from some bands with a loop in it. And I'll just have him, polka PVC pipe through it right from lunch and I'll move that weight back and forth. So they got a time it is, is focused. They're moving their heart rates up. Is this little things like that? So it takes a little creativity to kind of, once you have the basic understanding what's going on in the brain, and you can kind of get creative with. For the, the push up, we have Mark Bell slingshot. Is there anything similar to that for the full up? I wouldn't use. I I don't really use bands for pull ups on. And I explained this in the in the video that in the in the YouTube videos, we shot today is the reason why I don't like using bands for assistance in the pull ups is because the initial movement to do a proper pull up his scapula retraction, pull the shoulder blades back. Pull him down your back pockets the bounce at the bottom of the bandit. Pull up eliminates eliminates the strength requirement of pull him back down because you balance out of it. So you don't you don't recruit the must the Rahm boys and you don't pull the shoulder blades down you relied people rely too much on the bounce to get that. So they're really training, the top half of the pull up with the bands. And then they take the band's away and they're having struck. They're still struggling from a dead, hang of proper Denning, pull up in initiating that first movement. So I- progress them through either negatives, working from the top down to the bottom..

Mark Bell neurodegenerative disease Rahm YouTube Denning ten pound
"neurodegenerative disease" Discussed on Xtra Sports Radio 1300 AM

Xtra Sports Radio 1300 AM

01:32 min | 2 years ago

"neurodegenerative disease" Discussed on Xtra Sports Radio 1300 AM

"Ground. It's what we say. When our soldiers are deployed to protect our freedom abroad. But now, the bravest men and women among us our boots on the ground military veterans are twice as likely to fall victim to. LS the fatal neurodegenerative disease that robs them of the power to use their legs. Cold someone close. Solid meal. Simply say, I love you before ultimately losing the ability to brief. Most often remain aware and alert to the world around them as their bodies gradually shut down. You don't need to know a veteran with a LS less to know, it must be stopped that those affected your support joined the associations walked to the feet LS hopeless phone treatments and a cure for Lou Gehrig's disease? Phoned a walk you you want to defeat LS dot org. I ride at beans are guy Jason lockenfora on debt jail sec. I up time to ask the pros give you chance to ask us anything you want. Brought to you by Reilly auto parts is tweet us up at CBS sports radio. Use the hashtag ask the pros at CBS sports radio. Hashtag ask.

CBS neurodegenerative disease Lou Gehrig Reilly auto Jason lockenfora
"neurodegenerative disease" Discussed on Xtra Sports Radio 1300 AM

Xtra Sports Radio 1300 AM

01:55 min | 2 years ago

"neurodegenerative disease" Discussed on Xtra Sports Radio 1300 AM

"Neurodegenerative disease that robs them at the power to use their legs. Hold someone close. Meal. Say I love you before ultimately losing the ability to breathe. Most often remain aware and alert to the world around them as their bodies gradually shut down. You don't need to know a veteran with a LS to know, it must be stopped that those affected your support joined the A L. S associations walked to defeat LS and hopeless treatments. And a cure for Lou Gehrig's disease? Find a walk new you want to defeat LS dot org. Twenty. You know that song? Why play that song? Do you know.

Neurodegenerative disease Lou Gehrig
Jerry Springer, Stephen Helensburgh And Bill Nye discussed on News, Traffic and Weather

News, Traffic and Weather

00:15 sec | 2 years ago

Jerry Springer, Stephen Helensburgh And Bill Nye discussed on News, Traffic and Weather

"News for SpongeBob. Squarepants fans. Stephen Helensburgh who created the massively successful animated Nickelodeon series has died at age fifty seven no word on a cause of death. But Hillenbrand revealed last year that he'd been diagnosed with a neurodegenerative disease LS, you can call him judge, Jerry. Now, that's the name of Jerry Springer's new show that will have him sitting behind a bench dusting off his law degree to dispense Justice L debut late next year. The only win maintain green book is an early favorite to win an Oscar not the film starring Mahershala Ali and Vigo Mortenson was just named the year's best by the national board of review. Hello and welcome to the big brother house. Julie Chen moon Dez is returning to host big brother celebrity edition when the show returns for season. Two January twenty first. Save the more and Bill Nye the

Jerry Springer Stephen Helensburgh Bill Nye Hillenbrand Neurodegenerative Disease Julie Chen Vigo Mortenson Nickelodeon Mahershala Ali Oscar
Brain health: Low-protein, high-carb diet just as good as low-calorie diet

02:55 min | 2 years ago

Brain health: Low-protein, high-carb diet just as good as low-calorie diet

"Scientists Dr Devon wall pointed out, and he says, and I quote, we have close to a hundred years of quality research extolling the benefits of. Calorie restriction as the most powerful diet to improve brain, health and delay the onset of neurodegenerative disease. However, the majority of people have a hard time restricting calories, especially in the western societies. Like, the US where food is so freely available so plentiful it shows a lot more promise, then we have been able to replicate the same kind of gene change in the part of the brain responsible for memory that we also see when we restrict calories. However, a low protein high carbohydrate diet are by no means a new fad. One of the senior scientists behind. This study said numerous cultures including people in Japan in the Okinawa area and many parts of the Mediterranean have long observed this mix and show better longevity and less degenerative diseases compared to low carb high fat eaters, the traditional diet in Okinawa and other blue zones where people live longer generally into their past one hundred years of age, and they're still active right up until that time the traditional diet in Okinawa is around nine percent protein, which is similar to the university study. We're talking about here and a with sources, including lean fish soy plants and very very little beef. In other words, you go to these blue zones where people live long. Anger. They had the greatest longevity in the world. They're not eating beef. They're not they're eating fish. They're eating a Mediterranean style diet, which is high in unrefined unprocessed, high fiber complex carbohydrates, and when I say complex carbohydrates. That's what I mean, not messed with carbohydrates that have lots of fiber protein and other nutrients in them, so high carb diets could be just as effective as low calorie diets which had been studied extensively in promising a long life, at least in the animal model, and these researchers believe in the human model, and it can also provide good heart health and good digestive health and certainly good brain health. So when you hear people trying to confuse you try to tell you that carbs are bad. Remember, they are if they're refined. If there white if they're if they are the fast acting the high glycemic. Index the ones that have been messed with by man,

Okinawa Dr Devon Wall Neurodegenerative Disease United States Mediterranean Japan One Hundred Years Hundred Years Nine Percent
"neurodegenerative disease" Discussed on KTOK

KTOK

02:01 min | 2 years ago

"neurodegenerative disease" Discussed on KTOK

"Video streams up to forty, speed max Ramsey's rules and restrictions apply Protect our freedom abroad But now the bravest men, and women among us our, boots on the ground military veterans are twice as likely to fall victim to the fatal neurodegenerative disease that robs them of the power, to use their legs Hold someone close Solid meal Say I love you before ultimately losing the ability to breathe Most often remain aware and alert, to, the world around them as their bodies gradually shut down You don't, need to know, veteran with a LS to mow it must be stopped those affected your support joined the associations. Walked to defeat a LS can help us phone treatments and a cure for Lou Gehrig's disease Funda walk new you want to defeat LS dot org Party center as a pediatric, rehab hospitals, specializing in children with developmental disabilities from birth twenty one and we want to. Hire direct care specialist work with our patients as DCSS you'll help our patients to navigate, their daily schedule, around the hospital such. As therapy appointments school medical appointments meals and recreational activities and field trips candidates must be eighteen or older and have a. High school diploma and be a mature responsible team player, experience in working with persons with disabilities would be. Nice but not required will provide all your pay training this job pays twelve thirty, two an hour plus health insurance firm, vacation and, sickly and, retirement for more information call four zero five three zero seven. Twenty eight hundred and asked to speak to human resources this public service message is brought to you. By the McCarty center and, this station Checking, out, the, movies this weekend here's, your box office preview.

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"neurodegenerative disease" Discussed on KTOK

KTOK

02:09 min | 2 years ago

"neurodegenerative disease" Discussed on KTOK

"The fatal neurodegenerative disease that robs them at the power to use their legs Old someone close Alec, Neill simply say I. Love you before alternately losing the ability. To breathe Most often remain. Aware and alert to, the world around them. As their bodies gradually shut down You don't need to know, a veteran with, a LS to. Know it must be stopped that those affected need your support joined the. Associations walked to defeat LS can help us phone treatments and a cure for Lou Gehrig's disease To walk near you want to defeat LS dot org Venus your style guy for fashion and swindler is getting you ready to. Go back to fall the summer coming to a close the Vitas back to follow vent is a perfect time. To get amazing deals on, the side Venus famous from office hours to ask for hours this weekend only Venus is getting you ready to go. Back to campus, back to work or back, to real life ten percents off your entire order just go to Venus dot com or download. The Venus and use the promo code falls to kick off the the fall event we'd Venus Right, now join t. mobile and get. An unlimited plan with net flicks included so you can watch and more places than ever before get lost in space in your. Own backyard Watch a series of unfortunate events during a flat tire that's unfortunate you could even catch up on Santa Clarita diet over a big juicy steak Only at t. mobile watch your favorite shows. And movies and more places than ever before without paying more on your phone tablet or TV get an. Unlimited family plan with Netflix on us and right now by one Samsung, galaxy s., nine and get one free with twenty four monthly. Bill credits so you and your family convince your Netflix. Favorites on. Your new phones call one eight hundred t mobile or visit a store today Unlimited data on their network video streams at forty p small fraction of customers using, over fifty gigs per month may have reduced speeds if you cancel. Balances to customers full price seven twenty plus tax premiums.

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"neurodegenerative disease" Discussed on The FitCast

The FitCast

02:21 min | 3 years ago

"neurodegenerative disease" Discussed on The FitCast

"Where the research stands in the mechanisms now and then also on on factors that contribute to concussion patients who will have lingering symptoms meaning you know patients who may have symptoms for years on fortunately and some of the things that contribute to that like fringe since in my own experience you know hockey players or athletes who are concussed multiple times within a short window of time and then and then i'll be speaking as well about the musculoskeletal side of concussions evaluating and treating the neck things that you can do proactively in the weight room to to improve cervical cranial cervical stability and help protect about a against these injuries and also modifications to make for the athlete who are working their way back from a concussion so i'm really excited about it because i haven't seen a seminar like the and honestly i i don't know enough about cd neurodegenerative disease very much needed and it all went into political to everybody whether they be athletes trainers pt's strength and conditioning folks disease the front lines or even parents and coaches because these are the folks who deal in the front line with these athletes and unfortunately we don't have a good way of dealing with them so again that'll be may twelve and you'll be able to get more information on my website at a pal off pt dot com and that should be an excellent resource some really looking forward to that and you'll be able to learn everything you need to know about c t e and and in concussions hopefully that day and really opened spread the information far and wide you know just as just as an aside i recently got an email from a fella who's the head of sports medicine at shattuck saint mary's in minnesota big hockey school and you know joe when i interacted in the past and discussed concussions in the role of next strengthening and cervical stability entreating these folks in and preventing these injuries he recently emailed me in the last year to year and a half since implementing some.

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"neurodegenerative disease" Discussed on KOMO

KOMO

01:43 min | 3 years ago

"neurodegenerative disease" Discussed on KOMO

"Results or groundbreaking while the recent major injuries played a small role they found that smaller repeated hits notice a sub could custody hits also played a role contributing to this crippling brain disease injury on the one hand and we need to be concerned about the injuries can occur that triggers a neurodegenerative disease in some cases herman under what circumstances the family of penn football star o and thomas back in 2012 owen played football all his life never suffered for many concussions but did have several sub can cause of hits and just twenty one years old he committed suicide doctors leader fighting out he was suffering with early stages of cd when they asked for his brain i said well they never had any concussions adding that find anything i'm sure they wouldn't find anything but i thought well we'll do what we can to help bring search or whatever i was just astounded that they pounds sub can cause of hits like the ones owen thomas suffered they're not just limited to football they affect every athlete that plays impact sports disease paul affairs portions of the media or that crossover michigan you did not have been located on a frozen lake that discovery made yesterday nary near hamburg by larry atkins and two other people working with the american meteor society atkins used doppler radar to pinpoint the area where the meteor landed a total of six pieces of the space rock were found by the man those ross will be sent to a laboratory for analysis to certify their authenticity the am believes a meteor travel at twenty eight thousand miles an hour before exploding in the.

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"neurodegenerative disease" Discussed on Bulletproof Radio

Bulletproof Radio

02:21 min | 3 years ago

"neurodegenerative disease" Discussed on Bulletproof Radio

"The first is it turns out there are some interesting reasons why we don't live too old and the two are you know if you look back at at human age over the over the hundreds of thousands of millions of years back when food was scarce before there was mcdonald's in whole foods you would typically have in a baby's aged thirteen when you went into puberty and then you would grow to age twenty six which point your kid would have a baby and then at that time when food was scarce the worst thing you could do for continuing response she's would take the food out of your grandchildren's mouth as the as the more powerful adult and the best thing to do is give your bits back to the environment and so the average human age for most of all human history is was in your mid20s then we discovered you know better or sanitation and antibiotics and other than germ theory and so forth and we extended life we're about to tended double it again the other thing is that most people you know most women will be fertile till they're uh midthirties call it and if you've got a genetic disease that hit you in your 40s 50s 60s it's never selected against so we have cardiac in your fifties and sixties cancer in your 60s 70s neurodegenerative disease near seventy 72 '80s '90s the which wipes us out but with the massive reduction in cost of genome sequencing right my business partner craig venter sequence the first human genome in two thousand one cost one hundred million dollars nine months of time today the price has gotten down to a thousand bucks and a day less than a day and alumina the leading manufacturer gene sequencing equipment announced a hundred bucks and one hour so a million fold price performance increase incredible right and so we're starting to understand what is the software code were running and why some of us are are living longer than others and then we've just got crisper cast nine technology which is exploding in terms of capital startups we just started curie the frisch next diseases like beta thast cmea by you know.

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"neurodegenerative disease" Discussed on KGO 810

KGO 810

01:42 min | 3 years ago

"neurodegenerative disease" Discussed on KGO 810

"Change in her gate the way that she had walked and she started complaining to me about brain fog and this is not something that i had ever had any experience with um but you know enough complaints and you know me and my brothers was sort of like talk amongst ourselves and notice if there was like something different with my mom i ended up taking the time away from work to go with her to various you know doctor's visits first it began with primarycare physicians and ultimately culminating in a road trip to the cleveland clinic where we had our first of 11 with a neurologist and it was there that my mom was diagnosed for the first time with a neurodegenerative disease and that was actually yeah i mean that was it was really hard it was the first time ever in my life that i think i'd had a panic attack click an actual panic attack and from that point on i just couldn't you know my career counterfeited to the background ultimately that agency dropped me and i'm glad because actually made you a free meal but my my agent was also bitch so no i'm i'm hurts them dimarco but in the end it works out raising the assembling in the short term you know when we take that step back anytime there seems to be a roadblock in obstacle there is some new path that has opened yeah and in your case we'll you koindu when you describe like the heroes journey like the epiphany moment for me it was that you know that seen in the beginning of the matrix where the white rabbit construe concerns conscripts nieto who is ultimately going become nieto um to lead his life of safety and go on this incredible journey and that's exactly what i felt when my mom when this all sort of came to a head with my mom and.

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"neurodegenerative disease" Discussed on WBZ NewsRadio 1030

WBZ NewsRadio 1030

02:48 min | 3 years ago

"neurodegenerative disease" Discussed on WBZ NewsRadio 1030

"Lime organism that when there was a lion vaccine available between 1998 and 2000 those two proteins were in the line vaccine that's how specific there and yet today the western blocked has done at virtually every laboratory in this country omits bans thirty one and thirty four the western blood there was none of my daughterinlaw omitted those two ban so i sent her blood to a laboratory that does thirty one and thirty four and she was positive and then as i understand the story with a healthy dose of antibiotics you daughterinlaw who had been given four months to live yes i was able to continue a relatively normal life for seven years well hurt hurt illness stabilize with antibiotics and at the end of seven years she died of of it the totally unrelated ilna as but the answer is yes and i would encourage every patient who has a neurodegenerative disease whether it's multiple sclerosis ehlass parkinson's disease uh to be sure and have an and be properly tested now there's one there's a caveat and this is very very important so many of the neurodegenerative diseases are considered ought to immune as are many of the room with article diseases the fabra miles of the rheumatoid arthritis the systemic lupus you used the phrase auto immune in layman's terms what does that mean the body is fighting itself but body is fighting itself so that those patients the multiple sclerosis patients at all the new jet neurodegenerative and an room the logical patients are treated in some fashion with immunosuppressive drugs something if the immune system is fighting then you want to suppress immigrants rusty mixture of no sense keep in mind please the tests that are used to look at lyme disease measure the patients antibody production so if the antibodies are being produced by the immune system and the patients are taking an auto a immunised oppressive drug big there are means system is going to be suppressed they are not going to be producing antibodies so therefore you may have an invalid test result so again a false negative a false negative so in patients who are taking otto who are taking immunise oppressive drugs i would encourage them to stop the minutes suppressor drugs and then do what i consider as a when i call as a provocative test in chronic lyme disease the lime organism become sequestered it becomes.

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