17 Burst results for "endothelial dysfunction"
"endothelial dysfunction" Discussed on Broken Brain with Dhru Purohit
"The biggest killer in the world is heart disease but our traditional approach is pretty misguided and addresses the symptoms not the causes high blood pressure. High blood sugar high cholesterol. Don't just happen out of the blue there. Signs of imbalance of underlying dysfunction. That can be fixed. We've all been told. Why are we seeing more cardiovascular. As the number one killer worldwide is cardiovascular disease and cardiovascular disease is not just about the heart it's about the whole vascular system the whole into helius symptoms the heart as the pump that pumps out to the arteries goes to the smaller arterials. Then goes to the veins that goes through the capillaries and then back to paddock system. And that whole system is intimately tied in with our health. It delivers oxygen. It removes waste. And when we get inflammation in that system or gumming up of the pipes that's when we cardiovascular disease so our endothelium is one cell layer that lines the inside of our arteries and this endothelial layer is critical for our health. We want that endothelium working really well and it needs to be able to relax to allow blood to get to all the different tissues in the body and we know we can impact the endothelium if the endothelium is not able to relax. That causes our blood pressure to go up. What we know is we start to see endothelial dysfunction an inability for that theme to relax even before years before. Somebody actually goes on to have the diagnosis of hypertension. So you know it's important to for that endothelium to be able to relax and there's many things we can do that can help with that. We know for example that blueberries are amazing. Because the rich in these anthocyanins these fighter nutrients that can contribute to improvement in the endothelium. And we know that when people have with the quivalent to one cup of blueberries twice a day within four weeks studies have shown that you can drop systolic blood pressure. That top number on your blood pressure by as much as blood pressure medication. There's many things that can be damaging to the endothelium Oxidative stress for example. We know can cause damage to the endothelial layer. We definitely know that..
"endothelial dysfunction" Discussed on Cardionerds
"Up anger patient for consenting to have her story shared with the Cardiology and Medicine communities in general in the hopes that generations of cardiologists and clinicians May learn from her condition. We're dead. Grateful to her for her generosity. So in the next few minutes, I will add a few practical considerations to the care of patients with carcinoid heart disease on top of what you guys have already heard. So as you've heard carcinoid heart disease is a cardiac manifestation of carcinoid syndrome carcinoid syndrome is caused by visual active substances produced by neuroendocrine. Tumors. Most commonly those thoughts located in the small intestine with liver or pulmonary met Chris annoyed syndrome is essentially a function of altered tryptophan handling. So ordinarily less than 1% of them. Tryptophan is converted to serotonin but in contrast neuroendocrine tumors contain enzymes such as tryptophan hydroxylase and amino acid decarboxylase found these enzymes are instrumental in converting tryptophan to serotonin. There are also other metabolites that are produced including other radioactive substances such as histamine dopamine wage. Be kind and so the serotonin is usually metabolized by monoamine oxidase in the liver and lungs. But this process can be bypassed in the presence of liver and Pulmonary Mets bouncing in higher circulating levels of Serotonin the most common manifestation of high circulating serotonin is carcinoid by the Disease exemplified by tricuspid valve disease are so beautifully described just now by doctors men's srivastava and Abraham. So in addition to what our fellows talked about, I like to point out a few more less common manifestations of carcinoid heart disease. Wow. This list is actually reminiscent of the five failures that the cardian urge team likes to talk about. So in addition to valve failure we have coronary artery failure in the setting of endothelial dysfunction, which often do to change services High circulating serotonin levels can result in coronary artery spasm, which may present as acute coronary syndrome. We can also have ventricular or pump failure and this often. Is in the setting of high tumor burden and it doesn't correlate value their disease High tumor burden results in neuroendocrine tumors infiltrating The myocardium and this can be manifest as multiple concrete. Tumors are solitary. Well circumscribed cardiac tumors in the Atria or ventricles often associated with the atrial septum or the ventricular septum. And in fact, you might remember that the Duke University geology team in discussing very case of a hereditary restrictive cardiomyopathy actually included carcinoid heart disease as being when the differential for for an infiltrate of cardiomyopathy, in this case, when you suspect an infant rate of cardiomyopathy do to Carson or disease a pet-ct me actually be more useful for assessment instead of an echo. We can also get electrical failure atrial and ventricular arrhythmias may occur due to sympathetic nervous system activation by circulating radioactive substances. So next I'd like to talk about some practical tips for managing these patients and cardi Oncology Clinic..
"endothelial dysfunction" Discussed on The Peter Attia Drive
"The particle count via anymore Peter Dating mentioned quest has a particle number technique called ion mobility transfer that people they're not comparable all biomarkers you should consistently try and use of course, the same lab not always possible but the same ass say able be immunoassays pretty standard throughout the industry. It's not like everybody's got their own April Bsa Deanna Mark Vary widely the other big reason to do that consistency of results over time. Is SORTA. Later yourself you're going to read the guideline or maybe your patients are going to go all the guidelines talk about April. Be there is no guideline telling you to do a anamour l the L. P. or an im ability of the LP. So it's another reason to just stick with the April Bay and I think there are less false positives with the be it's just been my personal experience I've been in guy life and as we got better and better we just so often saw totally unexplainable discordance between L., D. L. P. N. April Bay The DAD is overwhelming for April base. I think that's where you should be in today's world as your marker of Atherogenic Lipoprotein. Yeah I think we saw that especially with the second generation and Amar, it was almost like it had become too sensitive. We were seeing discordance that far exceeded what the Framingham or Mesa data predicted the discordance should have been. and. That's really actually what took us to the ion mobility, ass say. But again I'm I'm actually very from a diagnostic and management standpoint. I'm actually quite comfortable with where we are I think the final point I'd add to that Tom is just the economic one. You know frankly I think the cost of APO be is at least in Canada and the only reason know that is because Allen's Neiderman is at McGill and you know he's been pounding this for awhile. I mean we're talking about a three or four dollar test. So there is no excuse for any physician to say we're not going to order your fancy ape ob because. It costs too much. I'm going to order the LDL cholesterol I think that excuse has lost all of its water. It's show true in Allen. Just published a beautiful paper where he's researched the cost of April essays 'cause you know even some of the people in the guidelines always Oh, we can't able be it so expensive that's an old excuse that is no longer applicable to two, thousand and twenty. So of all the technologies to quantity eight ATHEROGENIC TYPO proteins April be is the most affordable and even in a look lab sometimes change crazy. But if you tell a lab, you want to pay a cash price it's really pretty cheap. Let's go back to Canada macro point here around APE OB, which is a greater coalescing around the idea that that AP concentration matters so. I think it's very well understood that two of the biggest risk factors for cardiovascular disease are smoking and hypertension I. Don't think there is any ambiguity that cigarette smoking and high blood pressure increase the risk of cardiovascular disease and they both appear to do. So through a mechanism that weakens the NFL Liam or creates an injury to the helium. The question now becomes as you put it Tom. How Ironclad is the story that it's the AB bearing particle in the presence of injured endothelium that is the Trojan horse that begins this destructive trajectory of taking that cholesterol into the sub endothelial space becoming retained undergoing this chemical oxidation process, which then kicks off an inflammatory response that paradoxically as an attempt. To repair the damage results in what can be a fatal injury there are other hypotheses. For example, there are people who note, and we have I mean look I have a patient in our practice Tom you've weighed in on her case walks around with a total cholesterol of three hundred and something in ldl cholesterol of two hundred and twenty milligrams per deciliter. NATO be a hundred and seventy milligrams per deciliter. She's in her late sixties and coronary artery calcium score is zero. We have elected to not treat her with any lipid lowering therapy. In other words, there are exceptions to this. How do we reconcile that? Well let's the human body in medicine. As you know, not all smokers are gonNA come down one cancer chronic obstructive lung disease. Why not? If that's such horrible risk factor. I try to explain this and I've certainly seen cases like you say where all my God if I was just going to say, give me your April be or whatever cholesterol metric you're going on three drugs right now you've got no choice and maybe the old days we approach people that way but no more I think you have to individualize your whatever risk factors you discover that might wind up causing atherogenic and then figure it out. So particle number is. Certainly, a major factor that might force it in, but not always ended Delia function although you can certainly, if you review the history this and how do you really determine endothelial function? Not Everybody has serious endothelial dysfunction who winds up with de-subscribe particle number itself in some people can just make the particles go and I think if we take Moshe Dole who's not going to have a little bit of to deal dysfunction. So I agree with you, it's a combination of. Something about atherogenic particles be their number and dysfunction but I'm talking more and more. Now, when I discuss any TYPO protein I don't care which subgroup you want to talk about I. Think we certainly have to know it's particle concentration, but I like to talk about Parka quality. So what are the other attribute of any leipold protein that might contribute to? Its ather jainism earns in some perhaps not understood Ming re make it relatively. It's not going to generate atherosclerosis in our certainly have to be things like that going on. So as we're getting smarter, we're looking at other components of the life. Oh proteins that could be other proteins that are on that could be their complex Lipa Dome and trying to see. Connect- help us discern whether in you a given particle concentration is more worrisome than it is in the next and the next person. So there's a lot going on and also from the justice conversation listeners will know atherosclerosis after genesis is a multi complex multisectoral disease and that's why even when Peter and if we consult on a case and we Realize. In this person, we have to beat up April and get their particle numbers to more physiologic range with don't stop. Once we do that we examined in great detail for other things that might be injuring the entity Liam or the arterial wall and see are any of those treatable or so. So we're getting a little bit smarter than lie proteins, but there certainly is more to it than just particle number. Do we think that there's a limit to where the benefit of reduction becomes diminishing or even J. Curves in the other direction. So we discussed it in the first episode significantly we did. So again with Ron Krauss it wouldn't be you know the worst idea in the world a couple of years from now to sit down and do it again, reexamine the data but but again, I think the causal relationship between Appleby Atherosclerosis is as strong as virtually anything we see in medicine. for which you can't do the perfect experiment where you have to rely on natural experiments..
"endothelial dysfunction" Discussed on Plant Strong
"When I joined faculty, there I br had the only instrumentation that can detect and quantify nitric oxide. And! So then we got busy and found out these compositions of matter that would generate nitric oxide and we knew. How much nitric oxide, normal, healthy human being made over twenty four hours, and so we could dial in that level of nitric oxide. And we refine this, so we're period of. Ten years or so and really got to technology that did two things number one. Everybody can't make nitric oxide. We'd do it for you and then number two. It really fixes the reason. Your body can't make nitric oxide. Even in the face of a antiseptic Serena Botox so it overcomes a lot of the deficiencies, a lot of the hurdles that we as ourselves put put on ourselves because of the things we do. But I think still getting back to the physiology. In biochemistry of nitric, oxide, the best approach is to eliminate or remove the things in your life for body that are disrupting nitric oxide production. And, then giving the body what it needs to make its own truck side, that's the best approach. There's no better safety profile than that and it works. So you I? Think you mentioned earlier on the endothelial cells. My father is a huge fan of the Endo Cynthia. theol- Salads endothelial young. which as you I mean, explain I think is the innermost lining of all of our blood vessels right? Is this is this where a lot of our Nitric Oxide is produced from the endothelial cells. It is so we've quantified this so about fifty percent of our nitric oxide comes from the deal sales. And as I mentioned, that's the fifty percent of that goes away with time. And so that's the reason four age-related cardiovascular disease. So stop it so I'm a five year old right? Just by being a human being. In having you know. And endothelial cells coursing throughout my body is, are they just naturally producing nitric oxide? Just all day long. As long as that five year old is eating, a decent diet is active, but if you've got an obese five-year-old that sedentary. That's. Heating. Chips and cookies and Sodas all day. He has probably the endothelial health of fifty or sixty year old. So that tells us really the damaging effects of lifestyle on endothelial health biology. Okay, and so let's say on that five year old. That is eating really an atrocious standard American Diet. How quickly can I turn it around by? By. Bye Not disrupting the pathways and eating the right things, and all that I. turned around super-quick yet. Usually it happens in a matter of days I mean our bodies very resilient in the fact that it wants to do its job. The salesman of do their job. They just need. You have to give them what they need to do. Their job and get the stuff out of the way that's hitting. Do Their job so when you change your diet. I mean it's similar to smoking. You can stop smoking and see the benefits within twenty four forty eight hours later in terms of how you feel you breathing and a lot of that are basket related effects so same thing with diet if you eliminate all the post-prandial inflammation that occurs from eating a lot of process, nasty foods, the causes endothelial dysfunction. Then you don't get that inflammatory response and inflammations key driver disease so As I'm sure you may or may not know. We are. We are not fans of of meat..
"endothelial dysfunction" Discussed on AM 1590 WCGO
"O. F. F. we are back on the biggest sports day of the year that's right we're playing my interview with the game changers the cast of the game changers so let me set this up a little bit it is Sunday on January twenty eighteen I've never heard of the game changed before because they had never been around before they barely made it under the wire into the Sundance festival they were still at the feel like the day before so I went to the film at Sundance I was asked by their PR team to interview them and I said sure of course I love everything plant based I had been expecting something along the lines of what the health another great plant based movie what I saw blew me away and I was so thrilled to be with them huddled up in a snow storm in Park City Utah on a random couch in the corner nobody knowing who they were I was all about them having seen the film and I was the first one because really they had not made a splash until very recently now they've been on Netflix doctor Mason is gonna come back at the end of my interview with the cast he is also on the in the movie itself so he's going to come back at the end but now let's go straight to my interview from Sundance twenty eighteen with the cast of the game changers James thanks that's working with me today thanks for having me so I saw the game changers and I it's just one of my very favorite films at the festival tell me about your entire journey from researching about going vegan and being sort of shocked about it and then being angry about what you thought you knew right well I didn't go into that sort of Reno with any preconceived notions or even looking into the vegan diet I literally go injured told both of my knees had six months with what what can I do with my time started researching drive all the more recovery and performance and that's when I came across a study about the Roman gladiators sixty eight skeletons that Ron life the only known burial site in the world and the the the strong Jim calcium analysis and radio isotope analysis I could tell they were in eating almost exclusively plants and about sort of blew my mind for the combat troops and so you know spend all this time but a thousand I was in the first year reading peer reviewed science and nutrition nothing like that ever on we've been we've been led to believe this myth that we have tapped me in order to be healthy not strong athletic another animal products as well and she simply not true and that's of set me on the street in Jenny basically and then the mall and covered about how would be mocked the two and lied to by the industry that's when I realized you know I just thought again calandria about it because not only is it affecting people's performance but more importantly it's affect people's health the leading chronic diseases heart disease cancer diabetes largely are impacted by what we serve it's it's it's pretty aggravate along with director Lisa hi as you make some excellent points about how a plant based I can actually reverse some of these trends like colon cancer diabetes type two diabetes practice extreme charm in order for heart disease for example a plant based diet and controlled studies is the only clinical infections can help to show a reversal of heart disease pretty quickly yeah very quickly there's been changes in within a week or two I'm the angiogram you can see all three is actually opening up and that's never been shown with any drug or any other intervention and then into the dean Ornish went on to show the same with prostate cancer reversals dropping PSA levels and then now doing a study with outside was may believe they have reason to believe that that's going to reduce and prevent that as well so pretty and so interested to see those results when they come out so talk to me a little bit about the second I mean the first myth of meat I think is that you need animal protein or specifically you need me to be strong and then right behind that is you need milk for your bones so both of those are completely false but there's also this myth that if you eat a lot of needs you're really mainly ma'am tell me about that if that's false I think the real management record sort of it really call underlying math underneath all of this and you know eight out of ten vegetarians or vegans a female young men especially eighteen forty five many twice as much me as women in them but just less likely to switch because it's really based on identity in this myth that we've been sold and not only is it not necessary but the very foods the man thinking making them more masculine the exact foods that a weakening killing more men than anything else and so it's it's not just a myth that were you know this industries probably thing but that's actually killing in weakening you're more people than anything else and it really is the world's most dangerous Memphis it's killing more people than anything else and it's also affecting our planet and in a very negative way so we're going to get to animals on the planet in a second for sure but I think it's also interesting to note you're saying that there's a myth about a manly man it's a lot of meat but very directly in the film you say that it actually decreases sexual desire performance at center which I think is very interesting yeah we actually did an experiment with doctor Allen scriptures the lead delegate urology the American medical association and we are going to spend with the Miami Dolphins showing how you could reduce blood for two to eight or blood flow for two day out as if you had an animal based meal and and so when I mental distress I said with this affect sexual performance is it absolutely not only demand have increased prostate cancer rest the more animal foods the but also the the blood flow to the **** and one of the smallest from the smallest arteries in the body and so we didn't experiments in college athletes although districts that meet we documented that and there was significant changes to circumference and rigidity of erections and the duration of erections as well simply based on a single meal and that can last for two to eight hours of course what do you do off the traitor region of six hours or so you read again through this constant state of what's called endothelial dysfunction which is also a stir erectile dysfunction so I would argue here matter always saying oh well my wife doesn't want to sleep with me and my wife doesn't want to have sex but I would turn that around and I would wonder if it's really the men who are slowing up in this department so you want to help your sex life go eat some plants let me talk to you about one final thing before I bring in some of your colleagues are also in the film so you're taking the meat industry pretty head on here hang your and the milk dairy industry and you're saying flat out that this is a marketing scheme do you expect some backlash or have you had some already well I think there's gonna be some backlash official yeah we're in it we're ready and yeah I mean anything that's gonna nicely in fact that for profit sooner and as we show in the film they they they hire these sort of scientists from higher to generate false and misleading statements plea to confusion so the people long considered you know but it's good for you one day it's not the next and so basically I think that means she's going to create their own campaigns to try on some of the information but we know we have the signs I interviewed at department jazz at Oxford and yell and holler button the consensus between all of these acts but they might have slightly different views on exactly what we should be eating but they all agree that it should be a plant based predominant dia and the facts the science back us up because of course animals eat plants and so all you're doing is taking the animal out of the equation the animals get all of their nutrients from plants calcium etcetera it all comes from greens right back in and the protein all proteins originates in plants animals don't make that protein and so are the just the middle man and they're very inefficient middle man so not only are we do take a lot more calories in together calorie out for the protein you can get you know all the amino acids that you need from reading plans and that's the sort of the notion that plant proteins coming complete but as long as you're reading a wide variety of plant foods and and I'm not for and you're getting enough protein the science is very clean and the sources actually the relevant in terms of getting those amino acids and this benefits the plant based eating particularly around information and in the blood flow that's a better option but a new church the muscles and in terms of inner muscles and joints less information so far off the recovery back to training sooner and that next training session is actually more productive so leading to measurable and significant advantages and athletic performance so let's talk to your trainer Lou is here he can kind of sneak in so we're gonna run a tidy cats here today at Sundance pretty busy so let's talk to Lou and I'm gonna ask you very indiscreet question how old are you Sir I'm sixty one years old right so tell me about your daily work out at sixty one and your vegan okay tell me about your daily work out my daily work hours variety of things that I normally do but I start off with the morning about five o'clock in the morning sometimes for thirty what I do is I start off doing my cardio concept one machine stairs are even the bike and then I started doing things like high intensity training with the cat above club bells and the rope that we call the web so I go through all those things at least twice a week then I started doing that just regular strength training were just a regular weight lifting with dumb bells but usually I work out about five days a week between forty five minutes to an hour and fifteen minutes and I decided not to take so much rest and I try to be real consistent at what I do so I try not to miss time working out now since I've been here I I missed a couple he's but it's really tough to get Sundancer trouble yes but that's basically I do a lot of core training lot of functional strength training a lot of provided training so my train is always movie movie movie does that much rest in between so my metabolism when I get up is always burning I'm always very fat I'm always produce produce in a growth hormone as some trying to produce with hearty take any rest in between and that's what is the most important thing that I'm trying to do and when you do this our work out you might have I think in the movie you're talking about a hundred wraps at some point I want to make sure I get that right but tell me specifically about what you'll do in an hour like what kind of wraps and what kind of weight okay the rep that I'm doing what I do they have the reps would basically doing kettlebells so when we do like cannibal swings so we do kind of both wings we probably do fifty a set on each arm so that right there put you right now at a hundred reps so that we might go of fifty cleans and then cleans leads on for that now we're at two hundred reps Dougal fifty snatches so if we start to do all these left and we start doing high polls then we started doing a clean and jerk but with the kind of both we start doing we do those individually then we start doing a complex with them all together and one sets so we we make a combination of all of those together so now you're talking about if we're doing see twenty five of each so in five times twenty five on each form our our five times twenty five with both arms there we may do two sets of the complex training with kettlebells so that's how we easily get up to a hundred is very easy to do which is have to have the stamina most of all you got to be focused right here and not think about what comes next could we can do it with five or six guys and you still actually haven't recovered is that intense when you do it so you need to really focus and that think about that's a lot of reps that's an important what's important is can you really control your recovery get control of your recovery of reason you relaxation that way you can really get it to work at a given it comes you could becomes very quickly if you get three or four guys and that's why the nutrition really comes in as well as if you're eating the.
"endothelial dysfunction" Discussed on The Doctor's Farmacy with Mark Hyman, M.D.
"So a lot of the lot of the younger patients come in. And listen, my testosterone must be low because I can't get an erection. But that's not the case. It's it's other things that are while vessels blood vessel flow. Blood flow is a big problem. Now, why do people have lack of blood flow? It turns out that you know, atherosclerosis starts at age five you can start having plaque. Yeah. And the first sign of of erectile dysfunction is endothelial dysfunction. The endothelium is the inside lining of blood vessels. We have sixty thousand miles of blood vessels. I in our body, and how many miles in your peanuts. Well, so turns out that it's one organ not multiple organs the end of the system so people as cardiologists why are you dealing with erectile dysfunction because the first sign of endothelial dysfunction is a rectal dysfunction. The first presentation. That's someone's a blockage in an Audrey is lack of early morning directions or rectal dysfunction. Yeah. So you say that because he's absolutely diabetes is a big thing. Hypertension is a big problem. Alcohol is a huge problem when you have alcohol you have an acute inflammatory reaction in the blood vessel wall. But the most the most that we see is sugar sugar sugar is extremely inflammatory. If you have a Coca-Cola with the Donut or a coke or an erection choose within two hours right within two hours of having sugar. We can actually measure in the urine and inflammatory mediator. We can actually measure your blood vessel by looking at endothelial function testing to see that as basil constricted after sugar showed could could precipitate a heart attack. There was a it was a good video have desert. If you want to have sex is at the gotta pick your pick. What you want? So sugars shook is a big problem. But what we're finding out is blood flow is huge. And like you said to see the diseases or were you know, what we're eating and that that can affect us a lot. I wanted people to really get that what doctors appear just said is that sugar is one of the biggest causes of sexual dysfunction in while sugars, the biggest cause of inflammation inside the blood vessel lining, which is a big fans reducer of blood flow. It's all about blood flow..
"endothelial dysfunction" Discussed on The Kevin Rose Show
"Insulin resistance, and Appleby Nash, and all of those clusters of things along with all of the literature directly related to jeopardy, especially based on fasting and all of the fasting mimicking molecules rapamycin metformin. So let's just simplify the problem and say there's like a thousand papers a month that are coming out that are directly or indirectly relevant to what we do. I certainly can't even have analysts just reporting into me. So we have a head analyst Bob Kaplan who have talked about obviously beside my podcast Bunge and then analysts that are kind of reporting more to Bob. So if it were up to me like I would sit in a room with analysts every minute of every day. And that's all we would do. But I think just from the standpoint of trying to get work done. Mostly I try to talk to Bob every single day. And then Bob directs the projects out to each of the analysts. So that, you know, again, some of our projects are very proactive like we're asking a question and some of them are very reactive like the estrogen examp- rank. So proactive question would be, you know, patient asked once like what's really the best way to prevent blood clots on airplanes. And prior to that, I always just recommended patients take a baby aspirin before they got an airplane, especially if they have a high L P little a which is a pro coagulant, or if they, you know, have some other evidence of endothelial dysfunction, like elevated L P P L A two or something like that. But you know, when the patient asked me point blank, I was like well, truthfully. I haven't actually look this up. So that like that that's just one of one hundred examples of that of each year where we actually did all the research on that and found out that the data on baby aspirin sucks. Baby aspirin really doesn't seem. Matter that much in airplanes in blinded trials, obviously Hepburn would be the gold standard. But that's so impractical low molecular weight heparin, which is slightly less impractical. But for most people it's still overkill, and then we just started to find all of these supplements that you actually buy on Amazon. There's actually this product called flight tabs F L IT tabs that contains grass meaning like FDA, generally regarded as safe right molecules that are really good at thinning the blood in the manner that it gets basically sticky for lack of a better word in airplanes because airplanes have a couple of negative things going for your right? The hypoxia. So the reduction oxygen concentration increases the quake ability of blood, the dehydration does cause we almost always get dehydrated there and then the position wherein. So those are the things that are driving the risk. And then if you add on top of that, oh, you're a smoker or you're on birth control pill or some some other things driving. You know, is it a huge risk. No. But you know, when you're planning in a game of inches like all that stuff matter. Yeah..
"endothelial dysfunction" Discussed on The Kevin and Ryan Show
"But once we ran it with that, we got normal levels. Wow. And so routh who's the analyst who was basically doing all this work was like became, you know, an expert on. All of the different contaminants that can interfere with the Elisa based essays on hormones. Yeah. So now, we're looking we're like, oh my God. Like how many times have we been fooled by this? And so anyway, those are kind of like what I would call our clinical projects that are very sexy. But we're always sort of like responding to those things that were confused by. Well, this is I guess what the point I was trying to get. This is the difference between, you know, looking up Dr in ans ach, doc in going there and dealing with someone that has data that is five ten fifteen years out of date and actually having your own analysts, you know, inhouse that are currently do they report back to you on the latest findings. I mean, there's so many new published studies that are coming out every single day. This is something that really been struggling with over the past year or so so at last check about one hundred thousand studies make their way onto PubMed in the English language each month. But by most estimates fewer than one percent of those are actually relevant meaning. You know, something of sixty seventy percent of those. We'll never be cited again. Meaning they're not even remotely useful. And then of course, you know, a subset of those don't apply to your area of interest. I mean, I can't obviously keep up with most literature. I'm really focusing on literature that has to do with cardiovascular disease cancer, nerdy, gender disease, insulin resistance, and apple d Nash, all of those clusters of things along with all of the literature directly related to jeopardy, especially based on fasting and all of the fasting mimicking molecules rapamycin metformin. So let's just simplify the problem and say there's like a thousand papers a month that are coming out that are directly or indirectly relevant to what we do. I certainly can't even have analysts just reporting into me. So we have a head analyst Bob Kaplan who have talked about beside my podcast Bunge and then analysts that are kind of reporting more to Bob. So if it were up to me like I would sit in a room with analysts every minute of every day. And that's all we would do. But I think just from the standpoint of trying to get work done. Mostly I just tried to talk to Bob every single day. And then Bob directs the projects out to each of the analysts. So that, you know, again, some of our projects are very proactive like we're asking a question and some of them are very reactive like the estrogen examp- rank. So proactive question would be, you know, patient asked once like what's really the best way to prevent blood clots on airplanes. And prior to that, I had always just recommended patients. Take a baby aspirin before they got an airplane, especially if they have a high L P little a which is a pro coagulant, or if they you know, have some other evidence of endothelial dysfunction, like elevated LP L A two or something like that. But you know, when the patient asked me point blank, I was like well, truthfully. I haven't actually look this up. So that like that that's just one of one hundred examples of. Yeah. That each year where we actually did all the research on that and found out that the data on baby aspirin sucks. Baby aspirin really doesn't seem. No matter that much in airplanes in blinded trials, obviously Hepburn, we'd be the gold standard. But that's so impractical low molecular weight heparin, which is slightly less impractical. But for most people it's still overkill, and then we just start to find all of these supplements that you actually buy on Amazon like there's actually this product called flight tabs F L IT tabs that contains grass meaning like FDA, generally regarded as safe right molecules that are really good at thinning.
"endothelial dysfunction" Discussed on The Peter Attia Drive
"Like cancer and Alzheimer's disease. And after a slow. Grosses? It is very unlikely. You will find something that is necessary and sufficient they're very rare to find those exceptions these are such multifaceted diseases. And there are so many different ways to skin cat. You know, when you talk about cardiovascular disease, you've got like four completely different things that have to be going on to cause disease. You have to have like a proteins trafficking. The steroids into the Sunday zero space you have to have the endothelial dysfunction to enable that to get in there and get retained you have to have the inflammatory response. You take one of those things away you change the name of the disease and your other points. Great one, even if you can infer causality it's not entirely clear what to data than what's maladaptive. So our experiments really would show this might Conyers necessary tumor Genesis so syncing that paper you referred to Mander headed, I work graduations together. And the post doc when I was starting my post he was finishing his graduate training. Craig thomson. In the same lab, and we actually worked together an old friend of mine, and obviously Craig's of former mentor, and I like Lucan Leila. But that paper when it came out in two thousand and nine right around that point when it came out in science, we had sent our paper to science and showing that might communism tumor. Genesis that incented out as I don't come on this. No. So then we sent it to eleven other journals. No editor sent it out cancer cells cell nature nature medicine. You know, they just biology journal clinical MRI, nobody sent it out because. The review didn't say Miconje are not functional. It just didn't mention anything about my Qendra. It sort of just provided an explanation of the glucose glucose to lactate, why tumors show that and for the biomass the energy, right? That was the point. And and it didn't say it was sort of agnostic about my Qendra right in the review go back, but people misinterpret that and saying, oh, yeah. Might Akanji are not necessary is all glycolysis less target glycolysis. So eventually, the paper did get published in peony s and I think that's sort of started. I would argue. The revolution of looking at mighty Condron cancer other people were doing it as well. But, but we you know, I sort of became a preacher of just pointing out luck. If you inhibit the respiratory chain, you can decrease tumor. Genesis ten years later to the best of my knowledge. And this is really important because it goes back to the clinic as far as I know there, no clinical like drugs in the clinic that are necessarily targeting policies right now. They're potentially two drugs that target the mighty Qendra. What target specifically? So one of them is a complex one inhibitor that the info at MD Anderson have generated in the just published two papers in nature medicine different from fen foreman. They're fed form. And yeah, the different from metformin form of their much stronger, or they know the binding side, by the way, they used the same yeast, Andy I one complex one that doesn't bind to metformin but doesn't bind to their drug as well as a two show tested a Enda. So how will they prevent? Xia? Yes. So now, they're they're doing a trial in AM L. And so this is this is the million dollar question. And can you find their a window where maybe the drug it's taken up preferentially by disposition properties by leukemia cells or prostate lung cancer cells, but spares the brain the heart and other organs, which where you could have toxic. So that's the big issue. The good news is if you have complex one it will decrease tumor. Genesis the bad news is it might kill you. Right. So so we gotta find that window, and does it also work well with immunotherapy that's an open question, which is then the new kid on the block like does it help synergies with immunotherapy or does it prevent the function? So all of this has to be worked out. But my point is that there's some space in this area. The other one is a drug by Ruffy Ella, pharmaceuticals and a full disclosure, I sit on their scientific advisory board. Thank you. I'm not pitching anything years. Simply in fact, they were already doing this stuff. We're just sort of giving him some, you know, my little biological inside..
"endothelial dysfunction" Discussed on Bulletproof Radio
"Dot com. Okay. Just crashed your website, sorry, man. I'm aware. So it's a really exciting time and this'll be the first of a series of products the second one will be on diving because of some of the same concepts. We've learned and we'll go from there. Well, I would love to see one for high altitude mountaineering, which is something I did more of when I was younger. I'm to the point. Now, if I use bulletproof coffee and Kito prime I don't feel altitude the way I used to and even some of the guys who've gone up Everest are doing that similar stack. And there's many more things that I do for my own inflammation at all. What would you do to hack climbing a mountain? So I think that the I think there's a big role for inflammation. I think it's this. Again, this pressure change that's happening too quickly for the human body to respond, and it shouldn't happen, but very few people in human history climb mountains intentionally so I like what you're talking about ad the key tones because if you don't have enough oxygen, and you're not going to be burning glucose efficiently. So the kind of supplements you're talking about. I like, and then I think I would just keep layering them on basically, you know, I love polyphenyls. We I read thing in the world. I know you've done the hard work sourcing. This stuff is up lament and probably phenomenal. So I liked that one. I would just basically keep layering these things on. And there's one thing I would add actually do tell which is people get this vascular endothelial dysfunction at altitude. So the lining of your blood vessels isn't working properly. I really like adding cocoa polyphenols. So that stack. Yep. Because they really help with your and affiliate function. And they give you a little bit of boost of energy because there's usually some theobromine stuff in there too. So definitely eating dark chocolate or something a lot of people do, but they don't want to carry the weight, and there's really only one brand of cocoa polyphenols on the market funding of made by Mars, and I've definitely experimented with us. And there's good data on on them. But decided because you need four capsules I couldn't fit them in Pali phenomenal. But that's a fantastic suggestion. And I've also looked at things like might. Oh sweet. Which is somebody helps you make ATP and I've used that at altitude what about amino acids, do you play with us? Yeah. So I think that's a I really like seeing what people's bodies are deficient in. But you know for myself, interestingly, the like five HDP stuff doesn't do anything at all things. Rated the tire seen stuff does. Oh, yeah. It's in a few of the things I formulate when I was doing halted stuff L Gouda mean was something else that I appreciate Elga mean is an amino acid helps your gut helps your brain. But it takes out a ketosis. But not if you're taking brain octane because we're not gonna it's gonna metabolize. Anyway, do us L good me. I haven't been using it. But I have some races at altitude coming up, and I'll probably throw it in the stack. I would throw in your water bottle. That's what I did. All right. I've got one more question for you. And it's a question you might be able to predict because I'm pretty sure you've heard this show before..
"endothelial dysfunction" Discussed on WINT 1330 AM
"Carriages give us a call at the. Number and and also been asked a lot about stem cell therapy we. Have providers now so if you have. Any kind of joint related issue the the benefits. Of that, keeping you from having surgery. Back, surgery knee surgery shoulder surgery. Is pretty astounding very high percentages of outcome results that are that are extremely good. People are growing cartilage in. Their knees they're getting their knees to function like. They did when they, were thirty, I, mean, it, is, amazing, at, it, what we're seeing, in, medicine, with, stem, cell therapy it's harvesting he's taking your own cells see that's what's. Amazing about it you take. Your own cells and then re. Administer and put back into the body In order for these stem cells to begin to call aggregate and work and once they start to proliferate. Work in the cells. Repair and regenerate that's the beauty of it so I, would look into stem cell therapy and then of course IV nutrition, which is, where you take specific activated. Vitamins and minerals any oxidants and you can administer them to an. IV bag goes directly into the bloodstream. And gives great benefit to all the cells may just an amazing amazing. Way of, delivering nutrition to the body. Especially in someone that's heavily deficient or they need. That to, build their immune system whatever. It, might be it's a it's. A great tool triple two eight three seven two seven to give us a call Doing this like I'm so excited one tell you I just get so fired up so tumor or to Merrick however you to say it is one of the most thoroughly, researched plants really in existence so curcumin is one of the properties in it it's. Been the subject of. Fifty six, hundred peer reviewed and, published by, medical, studies, matter, of fact they found now they've done In a five year research project. It revealed over six hundred potential, preventative and therapeutic applications as well as one hundred. Seventy five distinct, beneficial physiological effects pretty amazing So they said that Lipitor out they also said that tumor it. Can be as affective as fourteen different drugs currently on the market right so there's this thing, in, drugs, called mechanism. Of action Meaning what the drug. Actually does what it's activity is in the body mechanism of, action so now they're saying. That the mechanism of action of tumor is similar to what we're finding in a lot of these drugs let me tell you what some of these drugs are Lipitor which is the, cholesterol medication a two thousand eight study published in the journal of drugs in are indeed found, that standardized preparation of of two Merick compared favorably. To the. Drug avoir Staten Lipitor on endothelial, dysfunction undergoing pathology of. The blood vessels at dries atherosclerosis. In associated with with reductions. In the inflammation an audit of stress and type two diabetes patients pretty, amazing? Corker steroids take your steroids right kept the inflammation down A nineteen ninety nine study published in the journal of phytotherapy found that primary polyphenol entomb rig which is a saffron-colored pigment known as Kirkman compared favorably to, steroids in the management of chronic anterior you the Itis which is an inflammatory eye disease and, another study in the critical care medicine medicine journal. Found that. Curcumin compared favorably to the corticosteroid. Drug Dexsa method zone That's off the chart to to. Think that amazing really. They did another study in two thousand three study in the cancer letters they found the same drug also compared favorably to the decks zone in a lung ischemia refuse. An injury model. Katia basically win there's injury to the tissue the decks methadone comes into custody, inflammation well they're finding the tomb Rick certain dosages can do that also for depression so Prozac was flu Oxygene a, two thousand eleven study published in, the journal of farm Farmaceutica said they found that curcumin compared favorably to both drugs in reducing depressive behavior in animal models Aspirin another one And they, said in. Vitro it works curcumin has anti platelet in, modulating effects With Antar or. Arth rightous therapy so anti-inflammatory drugs study published in the journal of. Oncogene rights cancer journal found that curcumin is was, resveratrol, found, in red wine red grapes. Were effective. Alternatives to the drug aspirin ibuprofen naproxen Doc, look, fanatic Amine Dexsa method zone. And Tamaki often so in even said that the anti inflammatory effect had anti tumor Regulating cells case it helps. To get rid of tumors now chemotherapy drug, Oxford platinum two thousand seventeen this. Is we're talking about tumor we're talking about regular tumor spice Indian spice they found the two thousand seven a study published in the international journal of cancer. Found that curcumin compares favorably to ox platinum as an anti proliferative Target against colorectal cancer cells it's amazing and finally diabetes metformin a two thousand nine. Study found in the journal, about chemistry they found that curcumin is. Effective. In suppressing and supporting insulin levels as. Met foreman, with the receptors okay it doesn't. Get any better. Than that that's strong so adding tumor. Into, your diet, every, single, day which I. Have been doing it for years. Is something amazing for you to do it's, inexpensive.
"endothelial dysfunction" Discussed on Bulletproof Radio
"We can't really do now i also have the the fortune of knowing the people who work on that problem day in day out in there for i have probably a little bit of a share some of their humility in how complicated that is i mean nature took a billion years to make that system so a couple of whiz kids from mit don't necessarily get to undo that in a decade but i think that that i view that is a very plausible step towards longevity another example that i think is actually going to be more challenging problem is going to be a reprogramming senescence so so certainly we've had proof of concept along that in there's companies like unity bio health that are actually doing really exciting work in that space but you know i think to get to the point where you know dave asprey can show up and say i want all my senescence cells zapped that that's sort of the engineering problem that comes after the proof of concept and so i think that to me is much harder to under stand i think the third thing that interests me the most is probably given that athar sclerosis seems to be the only inevitable disease in our entire evolution so you know once people reach their eighth or ninth decade if they haven't got cancer or dementia their odds of those things actually start to go down so the only disease that increases in its risk monotone without fail is authorised grosses and so i know unfortunately it is really popular in the blog is fear to talk about how heart disease has nothing to do with ldl and it has nothing to do with cholesterol all of these things but the reality is that's just payton false i mean this is clearly a disease that is driven by light proteins inflammation and endothelial dysfunction and those things when when you were exposed to those things in a time dependent manner your risk of those diseases almost universally just goes up as time goes on so while age is the single greatest risk wrath.
"endothelial dysfunction" Discussed on 710 WOR
"They found out their i q was actually affected their i q is a couple of points lower on average than the kids from from the country who are not exposed to all the pollution hey listen you're in new york you're in pennsylvania pittsburgh or philly you're in connecticut you're a new jersey i your kids are exposed to this kind of pollution when they gave them the cocoa their blood vessel started working again reversed the endothelial dysfunction of blood vessel because the inflammation caused by pollution was going down circulation was improved the inflammation and their heart decline when they took the blood tests and flammarion on the heart had declined inflammation in their blood vessels had declined and they were doing better academically within the first nine days coco is an antidote to the pollution that were breathing in on a daily basis up here in the northeast but in general coco is strongly connected to a lower risk cognitive decline a better ability to hold onto your brain so here's the journal of alzheimer's disease it's a whole bunch of academic research institutions in portugal and lisbon i'd love to go to portugal i really what i've never been and then they followed them for four years if they had cocoa over the four year period.
"endothelial dysfunction" Discussed on The Rich Roll Podcast
"Ugh extend the conversation let's talk about heart disease erectile dysfunction type 2 diabetes obesity dementia and um uh congestive heart failure another cardiac syndrome i care a lot about so what's the immediate step i mean hospitals this this has to be out of hospitals has any hospitals since world health organization banned processed meats none that i know of the cleveland clinic was going to but i think they've capitulated what do you do in your own life you don't eat less eat none that's for each individual to decide in any time you eat a food like that if you do couple it with an antioxidant fiber rich choice like green leafy fruits and veggies brightly coloured foods are this is fascinating study five years ago that if you walk down to a hospital lobby in pick a hamburger and eat it within an hour you cannot comment your arteries or dysfunctional cynical endothelial dysfunction a rather shocking statement that the food deserved on a patient trade directly commissioned murray's if you eat that same berger with a big slice a lettuce or a big slice avocado he actually don't see that same drop so it's kind of a rule if you're not following a perfection diet and you slip up yo take the antidote in the antidote is garden foods and produce foods and i'm certainly not encouraging people to eat those foods but uh eat them infrequently if you are any imbalance with nature's own antidote right it's it's it's were saying that all of the claims that are made and what the hell are validated and backed up with citations on the what the health website if you go to any is what the hell dot com or with the health movie dot com or some fi all united in the only on the show notes but they have a section where you can go and they basically par sout every claim that they make throughout the movie and then support it with a variety of citation be and i agree and then the worst example i saw in this dark davison involved was as easy dog z dog md.
"endothelial dysfunction" Discussed on KDWN 720AM
"There are some additional affects dunk your sharp patel division of urology at the university of utah school of medicine said although the study adds to the growing body of evidence linking endothelial dysfunctions erectile dysfunction the results must be reproduced prior drunk conclusions regarding aspirin therapy you know on erectile dysfunction has been studied a lot big things to pharmaceutical companies like pfizer coming out of agra and companies with light levin dress i also cetera having these drugs on the market and i've said if you ever go to a doctor just asking for via and you've never met the doctor that doctors should be asking you about your heart and checking your heart and if he does it or she doesn't get a new medical provide because if you are heavy blood flow issues going to the penis than you probably a blood flow issues affecting heart and affect the break that's just what happens so what we recommend is before you not that worried about you having sex y you know and and getting a heart attack we are worried that you may have issues and other vessels everybody seems to think okay well if i have a problem with i footage is my foot no if you have a problem with your foot let's say you have foot pain okay maybe that's indicative or something else would on your body because like if you're having poor blood flow to the penis you probably could have poor blood flow to the park to your body and you do not want poor blood flow to the heart to the brain what about the eyes is there a link between erectile dysfunction in issues with their eyes who knows maybe so smaller blood vessels could be in trouble those diabetes those with high blood pressure could be more risk those with high cholesterol could be more risk and so i really really command the companies that the pharmaceutical companies that have me these medications because of brought people to the doctor that usually what ago the average man did not want to go to the doctor think of it after they were sick but they want to walk.
"endothelial dysfunction" Discussed on KMET 1490-AM
"No contraindication i i'm talking about this of i'm i'm pardon me i didn't mean to be so rude uh there may have been something on your mind that you wanted to emphasize about the the show today on the show today i'm sorry go ahead oh no no no and i i agree with you i think that the focus of the show i specially as a segue from what you just talked about with cardiovascular disease and kind of diabetes is related to all of these factors and as you know metabolic syndrome plays into this uh entire educational format that we're talking about with the five different things that are related for uh uh the big five as i call him for metabolic syndrome the big have you got it out go ahead go ahead so if somebody doesn't know what the big five arts large waistline hide triglycerides level uh basically a poor cholesterol profile where you have too much low density liberal protein and not enough high the lipoprotein you have high blood pressure and you have a high blood uh fasting blood sugar uh like one twenty six or higher that then you have metabolic syndrome and metabolic syndrome plays into all of these cardiovascular problems uh bore i'll tell you it this simple strategy of keeping the arteries healthy odd the cracking and the arteries becoming the arteries becoming stiff this happens over the course of a lifetime in some people it's it's more accelerated and others due to their diet and lifestyle diet high in fat a high in processed foods salt sugar and fat sedentary lifestyle lots of stress not enough sleep and rest uh all of that contributes to coronary artery disease or otherwise and the endothelial dysfunction and you know heart attack stroke or some sort of cardiovascular vent uh it is the leading cause of death coronary artery disease is the leading cause of death in this country and has been for decades uh and not gonna get pushed out a number one slot anytime soon so here's a.
"endothelial dysfunction" Discussed on Super Station 101
"In rd found that standardised preparation of of tumor iq compared favourably to the drug avoir staten lipitor on endothelial dysfunction undergoing path algae of the blood vessels at dries atherosclerosis in associated with with reductions in the inflammation and oxidative stress in type two diabetes patients pretty amazing corker steroids or you this she take your steroids right kept the information down a nineteen 99 study published in the journal of phytotherapy found that primary poly finol into merick which is saffron coloured pigment notice kirkman compared favourably to steroids in the management of chronic anterior you the itis which is an inflammatory eye disease and another they're studying the critical care medics medicine journal found that kirkman compared favourably to the corticosteroid drug dexter meth is own that's off the chart i think that amazing really that another study in that 2003 studying the cancer letters they found the same drug also compared favourably to the decks the meth his own in a lung scheme 'your refuse an injury model case basically win there's injury to the tissue the and meth is all comes in cuts information will the finding the tumor certain dosages can do that also for depression so prozac was flew oxidation a two thousand eleven study published in the journal of a former farmaceutica said they found that kirkman compared favourably to both drugs and reducing depressive behaviour an animal models aspirin another one and in this in vitro it works kirkman has anti platelet in a modulating effects with antar for honest there are arthritis therapy so antiinflammatory drugs study post in the journal of oncogene rights cancer journal found at kerki men as well as whereas vera trawl found in red wine redgrave's were effective alternatives to the drug aspirin ibuprofen approx approximation di cla fanek i mean dexsa meth is own and to mock sutphin so even said that the anti inflammatory effect had anti kilmer regulating cells case it helps to get rid of tumors now chemotherapy drug oxo plan two thousand seventeen this is we're talking about two or we're talking about regular tumor iq spice the indian spice they found a two thousand seven study published an international journal of cancer found that kirkman can pierce favorably to oxo plan as an anti proliferative target against colorectal cancer cells it's amazing and finally diabetes with metformin a two thousand nine study found in the journal.