35 Burst results for "chloroquine"
What happens to all the other COVID-19 candidates when the first one is approved?
"Now we have staff writer John Cohen. He wrote a story this week about an interesting question what happens to all the other covid nineteen vaccine candidates when the first one is approved. Hi John. Hi. Sarah. How are you? I'm good. He could be let's be honest. We're both sick of the pandemic. Yeah. Absolutely. Let me leave my house that my child leave the house. That's all I want to normal. Yeah. Normal. Let's talk about vaccine candidates. How many are in studies now under study now and what does the trial landscape look like at this moment? Know they're forty two in human clinical trials according the WHO list? The World Health Organization doesn't update list that was as of October second in there about two hundred in development. Of, the forty two in clinical trials tanner in the last stage of efficacy trials, the phase three, we're going to be mostly talking about what's going on in the US those numbers reflect worldwide vaccine development that's global. The US has four efficacy studies underway right now, and these are all part of what they like to call warp speed all part of operation more speed. Yeah. Yeah and so they're going through trials going through all the same steps, but that could change once one of them gets. Approval, why would something changed about? You know what's going on with the other CO bids scenes? The concern is that the mediocre might be the enemy of the better or the best the way that we've set things up in the United States the food and Drug Administration has a mechanism called an emergency use authorization. It's received a lot of attention because of hydroxy chloroquine because of rim, Desa there, and because of convalescent plasma and because of diagnostic testing, all of those have used this pathway for. Approval and authorization essentially is short of a full approval and it says, Hey, were in an emergency we only minimal data that gives us an idea of this stuff working and then we'll let it be used widely. So why are we worried about the other possible covid nineteen vaccines? If for example, one gets a UA by November I the FDA has said in a document issued in June that the EU a could be issued for fifty percent efficacy. That's a pretty low standard to begin with. As. Soon, as you authorized the use of one vaccine, first of all, this is an ongoing study because they're going to use data for an e you a most likely from an interim analysis someone of axion efficacy trial is scheduled to take six months. An Independent Safety Monitoring Board looks at the data at certain pre scheduled time points in the case of these efficacy trials they look at. The data early based on what they call? It's are basically the end points of the study. The studies are primarily asking the question. Do they prevent symptomatic disease that the number one question they're asking? So that's an event. If somebody gets a symptomatic disease and these trials are scheduled to have one hundred and fifty events to reach their final conclusions, but they're going to take peaks at the data. At fifty events, a net one, hundred events roughly at fifty events a company. If it had strong evidence that the people in the vaccinated group as opposed to the Placebo group were doing better, they could seek you a based on fifty percent efficacy at that moment they ethically in a quandary because the people who are still in this trial, blindly a receiving either vaccine or placebo ethically you could. Argue you've gotTa Blind and tell the people who are receiving. Placebo. We've got a vaccine that looks good. Do you want to get it? So you've undermined that study from reaching it's real and points of one hundred fifty events What's more? Every other study underway has to let the participants know that the US has issued and ethically you have to give people the option of taking a vaccine. The FDA's blessing. People might walk out a trials who are in trials. If you were staging a new clinical trial, you may well have to compare your vaccine to the one that has received the authorization. Well, it's much easier to prove that something is better than nothing. But what if you have a vaccine that's fifty percent effective and that becomes the competitor not a placebo well. Then, this new vaccine let's say it has sixty two percent efficacy. You're comparing sixty two percent to fifty percent not fifty percent zero. It's really hard to see that small difference or even if they're equivalent, let's say they're both fifty percent. So you need a much larger study and it needs to go on for a longer period of time and it costs a lot more money we. Don't have. It's not likely that people involved in trials for other vaccines or even the people in the placebo arm of the one that does get approved would have access to the sack seen. That's a critical consideration. If supply doesn't meet demand, then we have an easy you were only giving outlets twenty million doses to the top priority people healthcare workers then for the people in other. Clinical trials they have no other option. Then the issue is not this great ethical dilemma, but remember were speeding things up with operation more speed in order to pump out three, hundred, million doses of vaccine from one company by as early as the end of January. So this problem, it's not here today because supply doesn't meet demand, but it sure could be here in late. January and. February march April who knows what we're going to have in terms of efficacy data and who knows what we're going to have in terms of trials in their enrollment. Remember we have a couple of trials that have been stopped because of side effects. When you put a trial on hold that means it's not going to reach its end point for even longer and that's happening right now with two of the warp speed vaccines. In your story, we don't want just one vaccine. There's some good reasons to continue to investigate and to look further afield even after one is approved, can you talk about some of those? For one thing we may need different vaccines for different populations. The elderly we know with influenza, they need a much higher dose because their immune systems don't work as well as they age we may need one that's tailored for pregnant women. Pregnant women are GonNA, tolerate a risk factor much much lower than everyone else. You might need a vaccine that simpler to deliver for some parts of the world that doesn't have a cold chain issue or you need to keep it at. MINUS SEVENTY DEGREES CENTIGRADE. You might need a vaccine that's cheaper for many countries even though it's maybe sixty two percent versus sixty, eight percent effective, it might be a better deal at the end of the day because more people can get it for the amount of money you have on top of all that we want a lot of vaccines because more vaccines means more supply we have an insurance policy of something goes wrong at a manufacturing plant. If a side effect crops up when it goes into wider use, we have this backup of other vaccines. So there are loads of reasons why we want a whole portfolio vaccines ultimately to prove safe effective. That's the. Case that you have to make to participants people who might be involved in trials. Do you think it's going to be effective? Do you think people are gonNA still volunteer to get a vaccine or not vaccine that hasn't been approved? You put your finger on a really important issue and that's who enrolls in a vaccine trial why it's not like you have cancer that's going to kill you and you're enrolling in a trial because you've exhausted all medicines and you're hoping beyond hope that this new treatment will work and Save Your Life. That's a completely different motivation to join a trial. Then a vaccine when you are healthy, you're joining this to prevent something from. Happening so ethically, you can argue that well, that person most of these people are doing it for altruistic reasons the really doing it to help other people and you can ethically approach people in a study and say, Hey, look this one vaccine got EU a based on the early data that it's fifty eight percent effective. We'd like to keep you in this trial and it's a blinded study and we promise at the end of the study is one of the bioethicists I interviewed said we promise at the end we're going to give you the better vaccine, but will you stick with this for a while so that we can figure out if the vaccine that isn't For us is worth pursuing going back to your cancer example. There are cases where a clinical trials is happening the people in the treatment group are doing so well that it's no longer ethical to continue to deny that treatment to the placebo arm. That's not what's happening here. It is a different equation, some ethicists. That, even in a vaccine study, a person has a right to know if they're a participant whether they're receiving a placebo vaccine if there is convincing and compelling evidence that the vaccines working but keep in mind too and this is something that I think a lot of people have a hard time getting their heads around wearing a mask and social distancing goes a long way toward protecting you from this virus maybe even more than fifty percent effective vaccine 'cause then you're walking around. With none of this protection or you're not taking it as seriously exactly and that's called behavioral inhibition. If a vaccine leads to behavioral discipline habituation and people dropped their guard, stop wearing masks stop social distancing they may be putting themselves at more risk even though they have a vaccine in their bodies
COVID-19: ‘little or no’ benefit from remdesivir: WHO
"Results from a UN coordinated international trial looking at four cave nineteen therapeutics have shown little or no positive impact on preventing death in patients infected with new corona virus, the Solidarity Therapeutics Trial, overseen by the world. Health Organization who found that REMM disappear hydroxy chloroquine, Lapenne Aveer. Rootin- and Interferon. appeared to have little or no effect on twenty eight day mortality or the hospital course of covid nineteen among hospitalized patients. The study involved more than thirty countries and investigated the effects of the treatments on mortality ventilation and length of stay in hospital. It did not examine other uses of the drugs such as preventive treatment, which would. Require further trials in a related announcement. The WHO said that Covid nineteen had also highlighted the increased vulnerability of people with high blood pressure to the coronavirus. The warning is based on data for more than one hundred twenty countries showing significant caveat related disruption to treatment for people suffering from chronic health conditions with findings showing these patients make up fifty to sixty percent of all deaths through covid. Dr Bent Mickelson director of WHO's Department of noncommunicable diseases said that more than one point one, billion people around the world suffer from hypertension mainly in low and middle income countries when it comes to call it nine, thousand, nine, hundred, hypertension, one, hundred and twenty two countries that has reported. US that in over fifty percent of the country's the healthcare services disrupted fully or partially fifty percent of the country's, and in addition we see a high number of is we don't have global figures yet, but we see in the rain show fifty, sixty percent of the people that are severely ill and died in hospitals from code have hypertension diabetes, and so forth and the working on the global targets.
Nine Pharma CEOs Commit to the “Integrity of the Scientific Process” in COVID-19 Vaccine Trials
"Breaking news out of the former suitable sector. Let's get to make. Good Morning. Good Morning Joe Nine. CEO's of some of the largest drug companies in the world announcing they've signed onto what they're calling a historic pledge to uphold the scientific integrity and put safety first as they are developing covid nineteen vaccines. These are basically the front runners in the vaccine race for covid nineteen, all of the companies involved in operation warp speed in addition to Merck Pfizer and its partner biotech Astra Zeneca Madonna GlaxoSmithKline Sanofi Johnson and Johnson and Nova VACs all signing onto this pledge to do essentially four things. They say always make safety and wellbeing of vaccinated people a top priority continue to adhere to high scientific and Ethical Standards Regarding. The conduct of clinical trials and the rigor of their manufacturing process they pledged to submit for approval or emergency use authorization after demonstrating safety and efficacy through phase three clinical studies designed to design and conducted to meet regulatory guidelines through a regulatory authorities like the FDA, and they say to work to ensure sufficient supply and range of vaccine options including those suitable for global access. They say quote we believe this pledge will help ensure public confidence in the rigorous scientific and regulatory process by which covid nineteen vaccines are evaluated and may ultimately approved and guys. This comes as vaccine development is moving at unprecedented speeds and we are hearing about some hesitancy. From folks to believe in the process and to be comfortable taking these vaccines especially as the FDA's leadership has come under question about political influence regarding convalescent plasma and hydroxy chloroquine in a recent change research and CB poll about thirty percent of people said that they either definitely not or probably not take covid nineteen vaccine, and so guys the company is trying to step in here to tell the public, they will keep safety I. Yeah. It's in response to rumors that we'd get an emergency youth authorization for for one of these vaccines before completing. The process there's always pressure on the FDA. obviously in especially with you know we're talking about life and death situations with with some of these drugs to to cut corners and I think they're just you know they're just putting it out there that especially with so many people when. Vaccines are such A. Controversial even before this people, you know what? The Anti Vaccine and everything else and we do remember back with with polio before we knew everything luckily nothing happened but you need to be sure. His longtime ago we know so much more and we know what's in vaccines. We know the scientific basis for how they worked meg. So I, I would be comfortable with. with one of these, the ad no mediated. Vaccine or you know if there's a small stretch of Messenger Aurigny I'll give it a shot I. I'm not overly concerned with with like contamination by some horrific virus that we don't see or something like that. You know make so. A wary public needs to be. Absolutely certain that that. We've. Crossed all the cross the is and cross. The is in dotted the teeth I just wanted to know we are coming up on that and that final stretch and the vaccine development process sort of inconceivably because this only begin in January really. But when we get to the end of October that's when Pfizer is indicating that they may see results about whether they're vaccine works and the FDA has scheduled advisory committee meeting of outside advisers, October twenty second, and so a lot of people are gonNA be looking at that date and saying, are we going to see data and how transparent will this process be So these are nine major drugmakers saying that their first priority is safety and I think this is hugely important not only for building public confidence in. A covert vaccine, but for protecting the sanctity of vaccines in general broader, we've had discussions with Scott gottlieb about this. The reason you don't want to rush through and push something out there that hasn't been thoroughly vetted with a phase three trial is that if there were problems with it, not only would it convince people not to take a Kovin vaccine, but it could undo a lot of the work that's been done with other vaccination programs around the globe I mean Joe. Brought up polio. Well, Jonas salk actually. Vaccinated his children. As some of the very first people testing this out so you know that was something he felt one hundred percent confident with we don't do things that way anymore. But there has been so much that that we have done with vaccinations diseases that we don't even think about anymore because over the last fifty years or so you know they've they've they've kind of gone away up very common This is just important not only for covert vaccination, but for faith in the vaccination system at large. Yeah it's so fragile. Public Health experts are incredibly concerned that a misstep here when vaccines are so important could shake the the fragile confidence in the vaccine system in general, and as you pointed out, it's this terrible irony of vaccines that they have rendered all these terrible diseases sort of non existent, and so we don't appreciate that vaccines did that for us. So there's a lot on the line here.
Twitter Restricts Donald Trump Jr.'s Account Over COVID-19 Misinformation
"Twitter forced the son of president. TRUMP DONALD TRUMP junior to remove a tweet that linked to a video spreading information about covid nineteen that the company labeled as misinformation. The tweet included a link to another now deleted tweets that featured the video promoting hydroxy chloroquine as a covid. Nineteen, cure donald trump junior's account was suspended from posting new tweets and told vice that it was a temporary lockout until the tweet is deleted, not suspension.
Medical misinformation, COVID-19, Big Data and Black Lives Matter
"Welcome to science fiction on medical misinformation, big data and black lives matter in this time of pandemic is in the months since these based of a virus heat. My two guests have occupied all of those worlds all at once. The TESHA Mitchell with you and joining me at two superstars of the world of digital epidemiology. They are mining digital data from all sorts of unusual sources, some very familiar to you to help us. Make sense of things dot Miami. Gender is a computational epidemiologist at Harvard, medical school and Boston. Hospitals Computational Health Informatics Program Adam Dan is associate professor in Biomedical Informatics and Digital Health at the University of Sydney. Etem part of your work as you suggested, investigates have health misinformation sporades on social media platforms in online forums, hell potent. has this pandemic being in terms of appendix of misinformation as well I? kind of feel like appendix Storms I'll take of misinformation for for a few reasons. Really I mean I just the sheer volume of of information that's being generated imposs- on. This some quite interesting studies have been done in computational social science to show that as we increase the volume of information that exposed to the influx throughout timelines, and makes it hotter and hotter for us to be able to discern what's actually credible, and so we're more likely to pass on less credible information to our friends and family and people paper now social networks, which makes it much easier to spread misinformation. And just as an example in a weeping collecting tweets about things like vaccines, all sorts of stuff for a long time, and says the first case where we were completely unable to collect all of the tweets that were related to of the pandemic. You know just attempting to collect it. We constantly ran into all of our API limits. We're unable to do all the stuff that we wanted to do so this absolute flood of information all the time, so there's too much data to work with yeah. Yeah and that makes it really hard for people to discern what's actually high quality information? What's credible information so that they tend to pass on things that may not be credible at all, but this two hundred reasons that I think that this has been kind of the perfect storm uptake of misinformation. You know there's a lot of politicization. When she mentioned already in a for example, it was reasonably obvious to those of us who looked at quality of clinical studies around the drug hydroxy chloroquine. that it was unlikely to be useful on the pandemic that it was some serious flaws in the way, the evidence was being discussed and the the way the study's being done, but when things became politicized around the drug, they quickly became sort of entrenched in the partisan communities that exist online and becomes much much hotter to to use elements to change people's attitudes on something has become politicized I. Think the other reason why is that? We had seen what I think. People become more susceptible to being affected by misinformation and letting it affect the way they make decisions in their behaviors when they're more concerned when anxious when I have a loss of control. In a feelings of uncertainty and loss of control are associated with conspiracy beliefs and. The fact we have is invisible threat that his CO. MAINTAIN A book. Such big differences in the way governments are responding stoneleigh created in Iraq kind of environment from certain feelings. Of Powerlessness, yeah, I mean. A global pandemic is the ultimate loss of control. Isn't it and it's tricky to know. Who attuned to in terms of expertise because science and medicine. Rising to Cape Up with all the variables with the very basics of this virus. Yeah, look absolutely right, and you know we have this kind of environment where there's just too much information making positive for us to tell the difference between what's credible and what isn't we've got strong. Citation makes hard to change people's attitudes, but evidence and we're in this situation. People find misinformation more salient, and then we'll likely to kind of absorb it, and then let it affect decision making, and it's been a really interesting to watch, but it's also sort of a ended a lot of the work that we try and do to study misinformation Maya Atom. maxine interesting observation there that. Misinformation, during this pandemic hasn't just sprung from conspiracy, theories or wellness theorists are wellness gurus. It's coming also from. At least science from scientists during this pandemic to an extent, because research is being done in a record time to try and chase down this corona virus, early results are being shared before they are robustly peer reviewed on so-called preprinted service for all to see. The media is picking up those papers before really they've been properly vetted by scientific colleagues, so it's an interesting phenomenon, isn't it? It is at is definitely an unprecedented time for the development of new scientific discovery and I think that one of the things that's very challenging. Science by design is meant to reinvent itself with every passing day. What we know today should not be what we knew yesterday. It should be better more refined more credible, and I think that because that entire process is not public in a way that it perhaps was not before or at least was not given the attention by the public that it is being given now I think that that definitely influences the way that a lot of early findings are now being interpreted and I think that even early findings that were credible and are now being. Not necessarily questioned, but are being overtaken by newer better science for scientists. This feels like part of the scientific process,
UK moving forward with megatrial for coronavirus treatments
"A UK mega trial designed. Test Treatments Cove Nineteen Haikai Sarah. We're talking about the UK's It's called the recovery trial and it hasn't differences with other ongoing trials of drugs for Corona virus. What are some of the big differences with recovery? The main difference in some senses said it's a really really big trial they have. More than two thousand patients now. In an outbreak like this if you really want to have really good clear, robust result, one of the most important things to include a lot of people to get a really strong signal of secrecy, that's something that recovery has been able to do, and really no other trial in the world has been able to get those patients numbers. This isn't a UK. And the United Kingdom has a lot of cases for its size. Is that one of the reasons that this trial has been success? Yeah, absolutely I mean if they didn't have that many. Many patients in the first place of today wouldn't be able to enroll that many patients some of the people I've talked to so for instance one of the scientists. He's from Norway. He was saying. The recovery trial is really successful in the sense that one in six patients that goes to UK hospital with Kobe nineteen ends up in the trial. Well, you can kinda wonder why they managed to include that many patients. One reason is that they have the National Health Service all the hospitals took part in that and the top doctors in the. The Nation wrote a letter to all the hospitals and all the staff. Saying you know here are the three trials that we want to prioritize in. Please try to include patients in these trials. If you can, so that's kind of how they they ended up with those huge patient numbers in the first place that allowed them to in a very short time. Get some some answers as a result of having all these patients enrolled and kind of coordination at the national level for recovery. They've seen a lot of results in a short time can. Can you talk about some of the drugs? They've been able to either give a thumbs up to or thumbs down to I one. That was a really big deal. Was the hydroxy chloroquine arm of the study so much has been set written about hydro or Quin, banning a lot of that was based on trials, either with very few patients or trials obsessional, so whether patients were randomized to either get hydroxy chloroquine or a different drug or placebo, but basically looked in retrospect and compared how patients did who got hydroxy in patients who didn't? The recovery trial date has the best data we have for civilian patients being treated with hydroxy chloroquine, and they didn't see a significant difference in how the hydroxy chloroquine group did versus suspended care. Group And they put that out in a press release, and within a few days, a lot of other trials that were ongoing that would clearly not have stronger results were ended. I wouldn't say it's quite the end of that drugstore quance Saga Probably, but certainly mocked the attorney on. And on the other side of the roster here we have a drug that actually help patients that were in the hospital, so that sex method zone. It's a steroid drug that's also been known for a long time quite cheap. It's widely available, so it's really nice drug to be shown to be effective against covid nineteen. There's been a lot of debate from the beginning about how much of the severe illness at the end in patients is really the overreaction of the immune system, and that's of course where the steroid drugs attack the pathogenesis really so they can have damp and. And Immune System, and the hope is that that will mean that that the symptoms of patients will be severe and people are more likely to survive, and then that turned out to be the case I mean they. They found that mortality when one third in patients that received accent medicine. That was really the first big randomized trial in this outbreak that showed a clear difference in mortality, the national. Health Service within hours after the result was announced, changed its standard of care to include some episode. This is pretty surprising. These aren't peer reviewed results. These are press release results. Yes. That's been a huge point of contention. There's just kind of tension inherent in this fast-moving pandemic between you know having really robust results in getting them out there as fast as possible and I talked at length with Martin Landry, one of the principal investigators of the about it his argument. Is You kind of get? The baseline results I. You can look at the data and see okay. There is a difference in mortality and might be some changes in the percentages, but nothing major, but then there's a lot of other data that you want to put in the paper that takes some. Some more work, so his argument was. This is an important resulted to change the outcome of patients right now so let's put it out and then try to get the paper out as soon as possible. After that in the paper ended up coming out I think seven days after the results. Yeah, it's a bit of a wild west. Now place is different. Hospitals have different standards of care like in the US. A lot of hospitals are using convalescent plasma. This is a blood product from a person has recovered from cove nineteen and they're using that to treat patients in the hospital. But convalescent plasma hasn't been subjected to the same level of scrutiny at the same level of evidence has been obtained. You know for that as a deck of Methadone the drug. We just talked about right and I. Mean that's the two points though that I find really interesting and one is. If you're going to give patients these drugs, anyway, you might as well be using that to generate data that then shows whether the drug works said they aren't collecting data on these treatments, so they are collecting data, very. Very. Often right, the problem is I. Mean it does back to what I was saying about randomized patients, you can treat patients with something and then say okay. We're collecting a lot of data and we'LL GONNA look back at how the patients did that. Receive Drug and how patients did that didn't but there's a hierarchy of evidence and really in that hierarchy a randomized trial just because it gets rid of all the bias season, who would receive a drug or not otherwise so everyone? I talked to really agree. Agree that we need in this particular situation that's condemning when you want to see as fast as possible whether a drug has a big effect on the hard outcome like do people die or do they survive what you need, a large randomized trials, and when you ask people why they do, it also goes back to what you were saying. A lot of people said when they tried to convince doctors to take part. The doctor say well, but I have a good feeling I think. I know what works, right. Right maybe I mean doctors sometimes willing to accept a lower standard of evidence to guide their decisions. It then becomes very difficult to get to that higher level of evidence because to do that. You need to accept that half of your patients are not going to receive whatever you believe to be the most useful. That's inherent tension in the whole enduring these kinds of trials when you have some observational data already, but you don't really have the kind of strong data that let's say with confidence. Okay, this worse. I'm here in the US. We have many many cases, but there isn't this sized patient group being randomized. Is that because of what we just talked about, or is it more a lack of coordination? The US has done one big trial though the National Institutes of health the first. Study that was a randomized placebo controlled trial that included a lot of patients. And did give a robust result didn't really see a difference in mortality, but it showed that patients receive from severe. Stay in hospital for a short time period. Why haven't more trials like that I? Think it is a lack of coordination. You can argue that the whole response in the US to this virus has been marked by lack of ordination, and then, of course it does help when you have certain structures in place so again. The National Health Service in the UK with all of these hospitals. Part of this National Health Service. Of course, it makes it a lot easier. You put in place this one structure, one ethical board, and then you kind of do it from there while if you have to piece together coalition. Coalition of different hospitals and different investigators, it becomes a little bit more complicated. I think right, but given the the sheer amount of cases, the US has had i. mean certainly data could have been generated that would have informed both the US and the rest of the world a lot better about what works what doesn't.
U.S. health regulators have pulled their emergency authorization for malaria drugs prescribed for the coronavirus
"US regulators revoking emergency authorization for malaria drugs promoted by president trump for treating cold at nineteen the food and drug administration says that the drugs hydroxy Clark went and chloroquine are unlikely to be effective treating the coronavirus health and Human Services secretary Alex Cesar dismisses the FDA's decision to drugs approved in the United States has been for decades if a doctor wishes to prescribe that working with the patient they may prescribe for any purpose that they wish to do so not only touted by Mr trump even used it he says to help fight covert I took it and I felt good about taking it I don't know but had an impact but it certainly didn't hurt me I feel I feel good citing reports of heart complications the FDA says the drugs pose a greater risk to patients than any potential
FDA ends emergency use authorization for hydroxychloroquine
"Federal regulators revoked emergency use authorization today of chloroquine and hydroxy clerical in to malaria drugs that president trump touted as potential treatments for covert nineteen the food and drug administration said today this drug may not be effective to treat covert nineteen the FDA said the drugs are unlikely to produce an antiviral effect and earlier observations otherwise the FDA said have not been consistently replicated Dr Simone Weil joins us from south shore health near Boston so what happened we are all trying to find a cure for Colgate nineteen act there was some profit with early studies that were done without the clerk went and everyone got on that bandwagon you really need to do something for these patients and there was a lot of promise however as we have progress and learn more we have found there's not a lot of any benefit to you I talked to Klara plan and that there's a lot of side effects we care about our work done about the yeah this is no small drug this is a powerful drug if they can treat malaria and it also used to treat lupus and rheumatoid arthritis so you know it has its particular you know but right but no specific study to say it's actually beneficial for covert nineteen so how big of a disappointment is this I think we all wore something that your Kobe nineteen routine so many debts and that healthcare professionals will help lead because we want to do something but I think that there is something that gets a cold we're going to go through it I think they did not really pan out the way we hope it works I know everyone including the president has tried it but I was trying to keep all of the data and that's what we're going we're going to buy it they find that the information that we have and date on the studies that have not been released take care there is not enough data to support the benefits are I thought the kora playing basketball coach in nineteen patients and a big error that ID back in particular the card yet I noticed though that the FDA said some of the clinical trials would continue is that a good practice given the potential side effects I really want to get more data in order to yeah and third what data not very effective for treating Kobe nineteen more thirty seconds but you know we don't want to continue giving it back up right now what what's the next best thing well you know we have a few things that we're working on and you know we're doing when does the day here as one of the big brown I mean I can do a lot with that is there are other biologic that we are using and of course the biggest thing is working on back seat it's rare that the public take such an interest in these kinds of treatments but this is the process is in a trial and error figuring out something that might work in and figuring out it doesn't work this is a long process although they are meaning once you have information that's going to be rather than about the date your browser then we go ahead and we continue that that is not very date I think a lot of people right so you want to stop okay Simone Weil's and ABC news contributor joining us from south shore health in Weymouth
Coronavirus: US withdraws emergency use of hydroxychloroquine
"The food and drug administration has ended its its emergency emergency use use authorization authorization for for hydroxy hydroxy Clark Clark with with the the drug drug president president trump trump touted touted in in the the fight fight against against corona corona virus virus ABC's ABC's mark mark rumble rumble are are joining joining us us on on the the komo komo news news line line what's going on with this mark yeah basically the FDA and other health agencies in the United States has said that since they first authorized an emergency use for primarily hydroxy chloroquine that's that's the main drug that we've heard about like quarter quarter Quinn as well said since they authorize that back in March in late March as more studies have come out as they've done more research basically they found that there isn't anything to stay statistically that there is a benefit to you using these drugs and that sensually the risks of these drugs which we know about these are decades old drugs that have been used for many other purposes they're not news so we know what the side effects are those side effects are really outweighing the benefit or any potential benefit and as time has gone on and they've done research they just haven't seen or been able to replicate some of these early reports that we heard back in March about the possible benefits of this these drugs and so while they issued this emergency authorization and time is gonna essentially say they can't justify continuing to allow this authorization and so they've rescinded it so they're saying ineffective and may also cause heart issues and now what is the White House saying about this after president trump talked about these drugs for quite awhile yeah president trump has been a a cheerleader of sorts for hydroxy Cork when and in fact claims to have used it himself for two weeks just a few weeks back when some staffers close to him and vice president Mike pence had tested positive he said very positive things to say about hydroxy chloroquine he says that he's spoken with medical professionals who have told him that it's a very good treatment and that they've seen very positive results it's had a great reputation and if it was somebody else other than me people say Gee isn't that smart however these agencies within his administration are essentially saying that that's not the case that there's nothing to support that that the risks that we know about outweigh the benefit of these drugs and basically the emergency doctor authorization had said that you need to take these drugs in the same dosing recommendations as you would for other things so the same dosage that you would take for malaria or lupus or other treatments that you use these drugs for and the FDA noted that the inability to go higher and higher dosage that could potentially bring on benefits would only lead to more risk so basically they were they hit a ceiling we can't take a higher dose of this and we're not seeing any benefit at levels that we know are safe therefore there's nothing essentially that we see as a benefit for the drug to be continued to be used and so especially the federal government will stop supplying this drug to state and local agencies for the treatment of cover nineteen only now lupus rheumatoid arthritis other think that these drugs are used for those will continue their unaffected but essentially that the FDA and and other health agency says this is this is not a valid treatment anymore ABC's mark rubble are thank you mark thank you
FDA ends hydroxychloroquine authorization for coronavirus
"The FDA pulling its emergency authorization of a controversial drug that president trump in pushing as a possible coronavirus treatment UBC's Marc Randall R. explains all the agency's about face in the letter the FDA said Monday its ended its emergency use authorization of hydroxy chloroquine as a possible treatment for covert nineteen saying that after reviewing large clinical trials the agency now believes the suggested dosing regimens are quote unlikely to produce an antiviral effect this is the same drug president trump took for two weeks after multiple staffers close to him had tested positive for covert nineteen and one he repeatedly touted despite health officials having raised concerns about potentially deadly side effects including hard to read me
FDA pulls emergency use authorization of hydroxychloroquine
"The FDA pulling its emergency authorization of a controversial drug the president's been pushing as a possible coronavirus treatment induces mark rebel art explains the agency's about face in the letter the FDA said Monday its ended its emergency use authorization of hydroxy chloroquine as a possible treatment for covert nineteen saying that after reviewing large clinical trials the agency now believes the suggested dosing regimens are quote unlikely to produce an anti viral effect this is the same drug president trump took for two weeks after multiple staffers close to him had tested positive for covert nineteen and one he repeatedly touted despite health officials having raised concerns about potentially deadly side effects including hard to
US revokes emergency use of malaria drugs vs. coronavirus
"The food and drug administration is revoking emergency authorization for malaria drugs promoted for treating the corona virus president trump has been promoting hydroxy caloric win and caloric win and had revealed he took hydroxy chloride could preemptively against infection a lot of people have taken a lot of doctors are taking a lot of people swear by it it's got a bad reputation only because I'm promoting it the FDA cited reports of heart complications saying the drugs on proven benefits do not outweigh the known and potential risks the move means hydroxy chloroquine and clerical and will no longer be distributed to state and local health authorities for use against the corona virus at Donahue Washington
The Skeptics Guide
"Hello and welcome to the skeptics guide to the universe today. Is Wednesday June third twenty twenty and this is your host. Steven Novella joining me this week or Bob Novella everybody Cara Santa Maria, had a Jay Novella Guys Evan? Bernstein good evening. Folks you all doing today well pretty. Trying hard, it's been a tough week and a tough week. That's happened since our last show. A little bit co vid. UPDATES I like we usually do so. The numbers are continued to increase of course, but you know in the US definitely is a leveling off. The parts of the country that peaked I are starting are the the new cases, the number of new cases are declining, but some other parts of the country where that peaked later are still on the upswing, and some are even spiking a little bit, and so we're you know again as I said before beginning that transition to the next phase where we're starting to partially roll things out, and I think the next month or two. Two is going to really tell a lot about how things are going to go, you know. Do you think that's because like the most populated cities it did tend to peak I and so even if like the more rural areas or suburban or less populated areas are now starting to see their cases peaking, it's just like in terms of gross numbers. Fewer people yeah I. Think so. Yeah, this is Dan. We're definitely getting into the more rural phase of the spread of the virus now right absolutely plus also in the news. No zombies have showed up yet Let's get. Out about that a little of both j little both all right Bob I'll I'll surprise you. One of these nights I'll come over your house. I'll dress up. I'll do the whole thing. But I imagine. How another hydroxy chloroquine study came out. This one showing does not protect people from acquiring Kovic. So you can give it as a preventive to people who are not does not reduce their risk of getting it. On the good side the study, the first study of convalescent convalescent plasma plasma from people who are who covered nineteen and got better. Show that it was safe. This was an open label trial. Not Out of control try. This is a phase. One safety trial showed that it was safe, and the I think it was like twenty people, or whatever in the study they rose more than ever one thousand nine of them recovered, so they they did. They did well the. Test, yeah, yes. This April plasma is with antibodies and so again not wasn't an efficacy trial, so we can't say really that it works based on this trial. We didn't feel them, but yeah, but it looked. It looks preliminarily positive, but we'd now. This will pave the way for for an efficacy trial where we compare it to. Control. So that's good and. Now half with you my second week working in the hospital and he'll nap. Have you had a recent test? Now? I've been tested. They're only testing happy only testing symptomatic hype. Initially we record the show last week I'd only were there for a few days and it is a bit of a shock know after two months of being in lockdown to be stroll around the hospital. Full of sick people was. Different experience. Culture shock yeah in a way, but now I'm sort of seeing the other side of it. Yeah I think we got this lockdown pretty tight in that. The people working in the hospital are all really diligent. What I mean like everyone's wearing a mask wearing gloves washing in and out of patient rooms are guarding the protective gear you know. Doing doing social. And and you know we've made lots of workflow changes. You know we're not doing the on mass rounds that we used to do. We've really changed how how we're doing things and they'll probably be like the new normal for quite some time absolutely. The next year's fair Paris fashion show is going to be you know gowns and masks, and all sorts of protective equipment might be you never. Know. What it! Might be, that's just how how interesting so I mean this is this is. A risk of four hundred and fifty thousand people, healthcare workers have contracted covid nineteen around the world. Aches so. Out Obviously it's a higher risk than. Being in the hospital I. Mean you think about it? A hospital is the worst place to be. Spreading disease covert, which was thinking about it, so it's a space. Building. Con- confined to some extent with tons of people. Many of whom are sick and you're people, large groups of people are moving around the hospital like literally going into different patients rooms. You know what I mean, so it's like it's a complete setup for the trainer allows all of totally this is why. The precautions have been have been increasing over the course of my career. You know over the course of historical time as infectious diseases get more menacing, and this is just the latest iteration of that, and I do think that there's going to be permanent changes to how hospitals functions function in response to covert one, thousand, nine, hundred, probably because over nineteen, going to be a permanent addition to our Germans fear so. Did you like there were changes after after Mersa started to become A. Hundred thousand people are in hospital. I mean there's there's specific protocols. If someone's mercer positive as specific protocol associated with that I, have one patient on my service now. WHO's positive? It's a gown and glove. Every time you go in, and that's always been the case since mercer was discovered. And it's very common so same things same things with other antibiotic resistant. Bacteria and also certain respiratory. Infections and tuberculosis like every time there's a new big infectious disease pretty much permanently changes practice, so, but the thing is so i. am feeling better I. think in a way is like we got this. You know we're doing everything we can do. We're of minimizing it. The professionalism is definitely there and I think. Healthcare workers is getting more experience with covenant. We're learning a lot about it, so we're sort of getting a grip on it, but there's just no way around the fact that it's a risk and that already there's been a huge price paid by healthcare workers for for being on
Study on safety of malaria drugs for coronavirus retracted
"Well several authors of a study that raised safety concerns about malaria drugs for coronavirus patients have retracted the report they say independent reviewers weren't able to verify information that's been widely questioned by other scientists Thursday's retraction and the journal lancet involved the report on hydroxy chloride queen and chloroquine drugs long used for preventing or treating malaria but whose safety effectiveness for covert nineteen are unknown that study linked the drug to a higher risk of death or heart problems a study leaders also retracting an earlier report using the same company's database on blood pressure drugs published by the New England journal of medicine that company coming under scrutiny for what it actually does a big investigation in the guardian on that company and how it operates and I'm sure it's going to get I. nine from somebody within the government and of course how the government came to views of that company and it's flaunted data as well and sure that will be taking a look at it too
Malaria drug fails to prevent COVID-19 in a rigorous study
"Researchers say they gave half of their eight hundred person study group hydroxyl chloroquine and the other half a placebo and found no difference in preventing covet nineteen the study is published in the New England journal
The dangerous use of off label prescribing in times of a pandemic
"FDA requires prescription drugs to go through rigorous testing for both safety and efficacy as a result only a small number of drugs that are developed are ever approved for use and then only for narrow indications so take for example. A drug called Gabba Penton. It was approved in the early nineteen nineties as an anti seizure medicine but it didn't work very well. So experts began to promote it for use to treat all sorts of other conditions including pain bipolar disorder attention deficit disorder restless leg syndrome and Alcohol Withdrawal Syndrome. It has not been approved for any of these reasons but doctors prescribe the drug heavily and Gabba. Penton is not the only example even if there is no proof and the FDA has not approved drug for a specific condition doctors can still prescribe it because here in the United States doctors are allowed to prescribe drugs off label in other words for reasons completely different than what they were intended for or for what. They were tested to treat. It stands to reason that Dr should only prescribe pills to treat conditions for which there is good evidence of effectiveness but that is not the case in the United States. These off label prescriptions account for one out of every five prescriptions. That means that twenty percent of all drug prescriptions are for conditions for which the drug was not approved so when the president tells us that despite warnings from the FDA. He's taking the Anti Malaria. Drug Hydroxy cleric win as prevention for COVID nineteen. It raises all kinds of red flags. Currently there is no. Fda approved drug to treat or prevent covid moreover several studies. Most recently in Jama have shown that hydroxy chloroquine has been shown to be in effective intriguing covid in effective. So how wide why? The president's doctor prescribed this drug went. Experts advise against taking the drug will because it was being prescribed off label for a non approved condition and the same is true for thousands of doctors who prescribed this drug for themselves for their families or for patients on the advice of a real estate developer. Who HAPPENS TO BE THE PRESIDENT? I suspect the public thought that the president knew something that the rest of us didn't inside information. Well IT TURNS OUT. He didn't the rest of US. Were reading the medical research and new. The drug was a very little use to those with. Covert the use of off label. Drugs drives up the cost of healthcare and exposes patients to unnecessary risks. Uncertain outcomes. Hydroxy chloroquine can cause abnormal heart rhythms and dangerous rapid heart rates. So doctors who've written these prescriptions without any scientific basis. Now have a moral duty to reach out and inform patients about the risk of medical treatment with hydroxy chloroquine and the lack of any benefit. And we need to rethink the policy of allowing doctors to write prescriptions for drugs that lack any proof of benefit at a very minimum. We should require doctors to inform their patients that they are being prescribed drug that has not been proven effective for their
Test Show 05-24-2020 00:00 - burst 3
"Another study with one hundred thousand patients around the world finds there's no benefit from hydroxy chloroquine and there is a higher rate of heart problems and death former vice president. Joe Biden's walking back this comment on iheartradio's breakfast club. I'm telling you if you have a problem figuring out whether you're familiar trump and you ain't black later saying that he does not take black voters for granted. Some of basketballs greats are honoring Jerry. Sloan the former UTAH. Jazz coach died from Parkinson's disease and other complications. The Dow was down slightly lower. The NASDAQ UP. Forty this is. Ap News the FBI's launching an internal review of its Michael Flynn investigation or rare after action review of the investigation of former trump administration. National Security Adviser Michael. Flynn has been ordered by. Fbi Director Christopher Wray. There was no information on. What sort of potential misconduct is being investigated? The review will be led by the bureau's Inspection Division which handles internal investigation into potential employee misconduct. The timing of the announcement comes two weeks after president. Donald Trump suggested that race status has FBI. Director was in question.
"chloroquine" Discussed on WTOP
"Chloroquine regimen German finishes I think it's in two days governor Hogan today announcing that Maryland will begin universal code nineteen testing at all state run correctional in juvenile facilities Fairfax county started I. Arlington county Fairfax officially canceling summer camps now saying hosting the camps resent far too many rest many other counties in the area including Montgomery prince George's have also cancel camps for the summer as recently as early may many U. S. healthcare workers were still in need of critical protective gear that according to a new poll by The Washington Post and it's us the survey of over eight thousand adults included almost three hundred who work with patients and health care settings nationwide and found nearly two thirds of those healthcare workers had insufficient supplies of N. ninety five face masks and almost forty percent say their supply of hand sanitizers was running low the results have a margin of error of plus or minus six and a half percentage points a new report says the white house's coronavirus task force over spends on medical mass cleaning machines have failed to meet promises according to NBC news the no big deal with Battelle memorial institute was originally sixty million dollars but notice obtained from a task force meeting show the potential cost to taxpayers quickly grew to four hundred thirteen million dollars and both scientists and nurses say the recycle mass broke down after only two or three treatments not twenty as promised no comment yet from president trump or vice president Mike pence nine fifty one after several cruise ships were ravaged by corona virus earlier this year the centers for disease control and prevention issue a no sail order in March that's stopped all cruises so how will the industry recover WTOP's Michelle bash takes a look in part three of our series travel in the new normal CBS news travel editor Peter Greenberg says of cruise lines they've got a problem because a lot of folks think of a cruise ship as it nothing more than a floating Petri dish however their passengers are very very loyal so look for passengers to eventually return in droves but first cruise lines are going to have to change floor plans and procedures what might that look like limits of people in the pools of the jacuzzi's end about Faye in which you'll never go near the food you will point to what you want and a uniformed staff member will play it for you of course changes cost money so Greenberg says initially you may not see the cruise prices go up because they want to encourage people to come back but those prices will go up to read more go to WTOP dot com and search travel Michelle Basch WTOP news tomorrow in the final part of our series Michelle look at how and where people will likely travel another staple of summer won't be opening as usual for Memorial Day we're talking about two pools in laurel Maryland the municipal and Greenview Dr tools will not be open for the holiday weekend mayor Craig moe said it's the best precaution to take during the pandemic Montgomery County said earlier this week that its pools will not open as well for Memorial Day the now convicted star of the Netflix hit tiger king is looking to make some noise again any hopes that president trump will hear it on a bus all the way from Texas Joe exotics presidential pardon team is on a national tour our purpose is to bring as much attention to this was a possible your glove A. K. A. big juicy is the private investigator on the case and says Joe is innocent he was sentenced to twenty two years in prison for abusing Tigers and a murder for hire plot they're now asking for a presidential pardon this president will understand biases and you'll understand his job killed her husband loves Joe has had a rough time in prison and he has no idea the reach of his story on social media.
"chloroquine" Discussed on WTOP
"Hydroxy chloroquine White House press secretary Kaylee McEntee tells reporters she also discussed the drug with the FDA commissioner Steven hot he told me that it has a good safety profile but should always be prescribed in the context of a doctor prescribing it to their patients Hans agency has warned against taking hydroxy chloroquine outside of a hospital setting out of concern it could cause heart trouble Steven Portnoy a CBS news Washington the World Health Organization threatened with losing funding from the U. S. is promising to look into the handling of the corona virus pandemic the organization has just voted unanimously to investigate the global response to the pandemic president trump has lashed out at the U. N. group calling it a puppet of China China accuses the US of trying to shift the blame now the World Health Organization is launching an independent review it's unclear whether this will look into where the virus originated that is CBS news correspondent Kenny McCormick Canada and the US have agreed to extend their agreement to keep the borders closed to non essential travel through June twenty first due to the pandemic Canadian prime minister Justin Trudeau says the border is a source of vulnerability so the agreement will be extended by another thirty days president trump has said that the US and Canada are doing well and handling the pandemic but many Canadians fear re opening giving the given the number of cases here in the US ascential cross border workers such as healthcare professionals airline crews and truck drivers are still permitted to cross coming up can you get covert nineteen twice twelve thirty four the following testimonials are from real green brook TMS patients I came to green brick with my hopes high that TMS might help me it took some time but I was not let down I feel I can handle life again so can you I am.
"chloroquine" Discussed on The Highwire with Del Bigtree
"You get kicked off of Youtube tons of studies showing that that is very effective. But we're talking about hydroxy chloroquine here. We're talking about the fact that people that take it on. A constant basis are not getting the illness that tells you something it also shows exactly what the study showed us all the way back in two thousand five not only did it seem to stop. The virus could actually prevent the virus. And so you have this really ridiculous study. That has now got everybody changing their minds. All right let's let's change gears now. Let's stay with the idea. I'm asking you do you think. There's a bias. There is a product however that Tony Pouch. She does seem to like now. Remember the hydroxy. Chloroquine is it is passed. Its patent okay. It's a generic drug. It costs my interstates. Like five or six dollars a pill no one can make any money on it so when you think about funding gangs in the funding and it goes to the national health and things like that you guys they. Nobody wants hydroxy chloroquine to be the answer. how much is it fifty plants? Sorry I I went imperial college on that and totally overblown number fifty cents. A pill is what they get from hydroxy chloroquine and remember the FDA's now saying we don't want to use it as only if you're in a hospital now by the way if you're pregnant and you happen to have heart disease and COPD and you're on your way to a malaria ridden country take this product and pop it like candy because we're not worried about it but if you're dying of Corona Virus. We're not going to give you a prescription and we're GONNA wait till you're dying even consider whether you should get it all. That's what's happening here in the United States. America's sad but true if you like that clip that'd be sure to check out our live broadcast of the high wire every Thursday morning at eleven. Am Pacific Time. You can watch it on facebook youtube. It end twitter we'll see..
"chloroquine" Discussed on The Highwire with Del Bigtree
"We had a drug that Donald Trump said the I want the FDA to make it available hydroxy hydrochloric queen is what we know it to be the malaria drug and Cuomo on top of everything else. While he's having these deaths surges decides. I'm GONNA limit your ability to get two hydroxy chloroquine we thought in this Newsday. Cuomo limits prescriptions for drugs to active virus cases. An executive order issued by Governor Andrew Cuomo this week limits prescriptions of one hydroxy chloroquine and chloroquine to cove in thousand nine patients in state approved clinical trials and FDA previews uses as an anti malarial autoimmune treatment and then only for a day supply with no refills. Basically yeah. It's a malaria drug other things. But you're dying right now cove in nineteen we're GONNA put you on a ventilator nine out of ten of you will never come back to us and I god forbid I decided to go with chloroquine where trials by DVR. Iu has a thousand people have gotten with a ninety nine point. Three percent success rate trials in China. Saying the same thing. You've got doctors. All over screaming that hydrochloric is having an amazing success. Now that's it all across the board for those were there watching and you are probably up on the using Dow. Jeez you should've touched the hydrochloric queen thing this week. You must have missed it right. You must have missed it. It doesn't work. The FDA is now saying it doesn't work. I missed it folks. We're GONNA talk about that. I'm not afraid of discussing things and look. It's all up for grabs right. I'm here to present the information. And by the way if Wanna be able to read and find all the studies that we referred to and your brand new this all you have to do. Right now is typing. Is C A N in your comments if you're watching on facebook if you're on Youtube we're on our on our website. The high wire dot com or I tunes or anywhere else. Just text US three three two two two and typing is C. A. and that's our nonprofit. I can and we will send you links to this information at least as much as we can fit in the buck if you really want our newsletter at the end of every week so that you can go to your friends and show them all the Lincoln look really smart and had read the thing yourself and have come to your own understanding. Then you got to donate to the informed Consent Action Network for everyone whether it's ten cents twenty cents fifty cents a month or a thousand dollars a month. Because you're making up those that are you know maybe. Having a harder time please donate become a recurring donor. Recurring donors are newsletter. We're asking for twenty dollars. Twenty twenty the end of the month. We're a little bit short. You can help us this month. We WanNA keep it going. We WanNa keep going strong all right. Let's get to it. Did I miss the Corona virus the core Queen Headline No. Here's what the FDA had to say in a thing that was put out this week FDA cautions against use of hydrochloric queen or chloroquine for Kobe. Nineteen outside the hospital setting or a clinical trial due to risk of heart rhythms cart. Rhythm problems we've been hearing about this right well. What about the heart rhythm problems? When I talked to my friends that are liberal states. They all are really on top of this heart problem. Other people that tend to be watching Fox and things. You're saying. Oh Man I have a friend who was saved by hydrochloric when it was really great so bizarre and such a clear divide but what was fascinating is. It was a divide from the very beginning. I WANNA to go back to think. It was about five weeks ago when we played video. How DOES DIVINE START? And how has it affected these discussions? This is what I want to talk about today. Take a look at five weeks ago. This was trump in foul cheat talking about hydrochloric clean the media themes to enjoy looking for the tension between you and the president a drug called chloroquine and some people would add to it. Hydroxy drug she clarke today. There are no proven safe and effective therapies.
Trump Urges People To Take Hydroxychloroquine: 'What do you have to lose? ... Take it.'
"And I say it. What do you say to get? What do you have to lose on Saturday? President trump again touted the use of hydroxy chloroquine an anti-malaria drug as a potential treatment for covert nineteen the USC announced has stockpiled. Twenty nine million doses. Though the basis for using the drug to treat the disease is entirely anecdotal. Some doctors are already using it in hospitals around the country. Some report that it might be useful in the early stages of covert nineteen. But we really don't know. And what do we have to lose? There are side effects. Experts warn and it is potentially fatal for patients with heart problems or who are on certain antidepressants. And then there's the side effect of a shortage for people who are actually prescribed drugs clerk in four illnesses like lupus and rheumatoid arthritis yet. We have to be careful Laura that we don't assume something works based on an anecdotal report. That's not controlled and I refers specifically to hydroxy chloroquine. Dr Anthony FAUCI Director of the National Institute of Allergy and Infectious Diseases has been urging caution in White House briefings
"chloroquine" Discussed on Limitless Mindset
"Here's why I fear that. Subsequent coming waves of the pandemic may be worse. The Rush Job vaccine that big Pharma rolls out will not be safety or placebo tested. There will be a huge global. Push TO GET ALMOST. Everyone vaccinated many places. The state will totally disregard informed consent. And we'll just force the population to be vaccinated and vaccines tend to Cause Immuno suppression. I linked to some sources on this. This is why you always hear people say I got my yearly flu shot and then I got the flu anyway. I expect that the coming vaccine will work more or less the current flu shots that we have. The evidence indicates that they only work about half the time. But I think that it will work more or less for the current cove nineteen strain but the virus will mutate and the vaccine will render multitudes more vulnerable to the life threatening pulmonary effects of the virus a paper published in the esteemed journal plus one warned that previous SARS coronavirus vaccines resulted in pulmonary. Immuno pathology quote these SARS cove. Vaccines all induced antibody and protection against infection with SARS cove however challenge of mice given any of the vaccines led to occurrence of the T. H. Two type Immuno Path Oji suggesting hyper sensitivity to the SARS. Cove components was induced caution in proceeding to application of a SARS cove vaccine in humans is indicated. And perhaps you're thinking Jonathan don't be a silly conspiratorial Anti Vaccine. Scientists on television are always telling us that vaccines are safe and effective. You have the right to your own opinions but not to your own science. I believe in science. Well I also believe in science but I've read enough to understand that there's a lot of bad science out. There do your best to research science and evaluate the evidence instead of just listening to make up embellished experts on television. But there's a tremendous signal to noise problem in science. We may not all be qualified to understand complicated science but we have the rational capacity to ask Kit Bono who benefits from the science that we are being told to believe and I will quote from Bill Sardi who is an author and researcher. Who's done some great analyses of the effects of vaccines? Here's what he had to say about a coveted nineteen vaccine. Everyone on the planet is expected to hold their breath. Metaphorically speaking and wait for a future vaccine that will buy my predictions end up hospitalizing. Many and leading to hundreds of thousands of high risk individuals like diabetic smokers drinkers and the frail elderly. Lead them to their early demise because these are the people who do not develop sufficient. Antibodies following vaccinations. I penned a prior report EXTRAPOL- extrapolating from published flu studies which predicts that six hence to one point three percent serious side effects after mandated corona virus vaccination. Among the nation's seventy two point six million senior dolt would hospitalize between four hundred and thirty five thousand nine hundred and forty-three thousand and a subsequent one point four mortality rate would then result in fifty four thousand two hundred eleven thousand deaths approximately so. He's looking at the data. That's out there about the incidents of serious side effects and yes mortality that occurs as a result of vaccination we know from the data that the government collects on vaccines because they have a big database. That is actually publicly available. We know that Among infants among children's the vaccinations result in something like four to five hundred deaths every year. So there are more. There is mortality verified mortality that does occur and when they are gonNA force or strongly strongly encourage large large amounts of people that death toll given the proportion of people that are gonNA be mandated or required to receive a vaccine. It's going to be very very high. It's going to be a a death toll. That may totally eclipse what we are seeing with. Cova nineteen so a lot of people are talking also about chloroquine and I expect chloroquine to be demonized in the coming weeks and months because it seems to be a highly effective solution for more serious corona virus cases. And here's the thing. Get this even in the United States where we have higher drug drug costs. It only costs five dollars and thirty cents quite affordable right. Big Pharma will make unprecedented prophets tens if not hundreds of billions of dollars off a corona virus vaccine this year or perhaps next year when they come out with it and every subsequent year as the virus mutates.
"chloroquine" Discussed on Without Fail
"Well there are a couple of studies in Petri dishes where it looks like putting Clark when onto cells protects them from getting infected with corona virus. And we got a hold of some very early unpublished data coming from a clinical trial in China. It had around two hundred people in it and it found that those who got Clarken won't fevers. Went away faster than those. Who didn't but what might have kicked off. A lot of these talk of Clarkson was a study out of France. It took thirty six people with these corona virus and gave twenty of them hydroxy chloroquine. Some of them got an antibiotic to and the research has said that. These treatment eliminated the infection in some patients. It did look very promising but Kind of our the the attitude. That's been done around us that you had with the caution. The reason that Matt isn't that excited is because the study was basically a small grab bag of different patients and not all did well. Here one died three was sent to the ICU. And just generally. It's a pretty small study definitely a good first step in differently meaningful. But there's still a question of how meaningful on top of this. Another small study of thirty patients in China. Found that Hydroxy Clarkson didn't help their symptoms so what to make of all this. Well we need more data and there's actually more than a dozen clinical trials looking into this right now and one of them is Matt in the last week. His team has started recruiting people from all across the country. And he's trying to see if hydroxy Clarkin can help people who are sick but also in a separate part of the trial they giving it to people who've been exposed like healthcare workers to see if it can keep them from getting the virus. They've already enrolled around five hundred people or and if you very short. When do you think you'll get results? Were hoping in for six weeks near the individual will have a preliminary sort of sums up some zone on whether this is working.
"chloroquine" Discussed on Without Fail
"Welcome back sorry. Chloroquine is making headlines Right. Now what is it well? It's a drug. That's been on the market for decades. It's often used for Malaria. And it's old people have been taking it for around seventeen years and there's a few different kinds of this drug like hydroxy chloroquine that's used for diseases like Lupus. So chloroquine has been hanging around fees doing its thing but this week story of this drug took a bizarre John. Hello Hi can I speak to Daniel Brooks Dan? He's a professor of toxicology and the medical director of the banner. Poison and Drug Information Center in Phoenix Arizona. People call his hotline when they're worried they'd been exposed to something toxic. Can we take calls from from people? Generally Cabeza exposures rattlesnake animations rattlesnake. Yup that's the second one he said. Yeah we we get like about eighty or eighty five rattlesnake patients here the recently something else has been rattling. Dan as the corona virus started to spread in the US. Stan was getting worried that people would take matters into their own hands and start using homespun treatments and Dr Google to cure all their coughs and fevers. We've seen happens dozens of times before I mean. You know we just see. We've seen this with Influenza WHEN WE'VE had bad years with influence and you know we've seen this over and over again. Dan says for the flu. People will try all sorts of stuff and in this pandemic. He says people even calling his poison centre to see if they should take blake to avoid getting sick with this corona virus. And so we just knew when as more and more things were being promoted to our he'll prevent Cova so we just tried to get out and warn people last Friday. Dan's team reached out to some medium to try to get the word out about. This should be released that unfortunately within forty eight hours we had our first survey you know. Our our prediction came true. Dan's poisons Santa got a coal from a couple in their sixties. This had heard all the excitement around Clark wine including what trump was saying about it and then they got concerned about some vague symptoms that they interpreted me have been for colonial buyers like a sore throat or cough something like that correct forrest. It was only the husbands but they became concerned about it and they decided that They may be able to prevent or treat. Chronic viruses the home products that contain chloroquine. The woman involved talked to NBC about what happened? She said that she saw the stuff in a pantry. That had Clark wine in it. It was something that she used to keep fish healthy..
"chloroquine" Discussed on Science Vs
"Well there are a couple of studies done in Patriot dishes where it looks like putting Clark when onto cells protects them from getting infected with Corona Virus. And we got a hold of some very early unpublished data coming from a clinical trial in China. It had around two hundred people in it and it found that those who got Clarkson well. They've fevers went away foster than those who didn't but what might have kicked off. A lot of these talk of chloroquine was a study out of France. It took thirty six people with these corona virus and gave twenty of them hydroxy chloroquine. Some of them got an antibiotic to and the research said that. This treatment eliminated the infection in some patients. It did look very promising but Kind of our the the attitude. That's been around that. It should be viewed with caution. The reason that Matt isn't that excited is because the study was basically a small grab bag of different patients. And not all did well. Here one died three was sent to the ICU. And just generally. It's a pretty small study. Definitely a good first step in meaningful. But there's still a question of how meaningful on top of this. Another small study of thirty patients in China. Found that hydroxy chloroquine didn't help symptoms so what to make of all this. Well we more data and there's actually more than a dozen clinical trials looking into this right now and one of them is Matt in the last week. His team has started recruiting people from all across the country. And he's trying to see if Hydroxy Clark can help people who are sick but also in a separate part of the trial they giving it to people who've been exposed like healthcare workers to see if it can keep them from getting the virus they've already enrolled around five hundred people in very short amount of time. When do you think you'll get results? Were hoping in four to six weeks near the individual will have preliminary sort of sums up some stony hamster on whether this is working or not four to six weeks and while we're living in self-isolation this might feel like an eternity in the land of science. It's the opposite. Many trials like these take us to recruit enough people and then analyze the results. Honestly it's it's he an insanely fast turner sometime in clinical trial and not trying virus. My coffee with social distancing went over the phone so it's different. Yeah and since we are in desperate times away heading into desperate times for doctors on the front lines now if they do have patients. That aren't doing well at all. Should they just give them this drug given even with this preliminary data? We've got well. I mean I think ethically it would be very questionable for me to without any solid data to to give that kind of recommendation. Unfortunately but I guess we you know we've got the French data the Chinese data. That's promising I feel like we've we've tried things with less data in the desperate times. We don't know if it will work yet. We'RE WE'RE OPTIMISTIC. That it will but yeah as a physician. I don't WanNa give anyone the impression that this medication has been proven to work some academics that we reached out to agreed with Matt others said the VIDEIRA doctors on the front line who are running out of options for their patients while chloroquine might be a good option now but everyone agreed that for us it home until they is more data. You should not be taking this stuff for corona virus already. We're hearing that. The demand is creating shortages and remember. There are people who really need this drug for other stuff like lupus. Meanwhile Dan over the poison center in Phoenix has some wise words for us. If you seeing any exciting stuff online or uncle bill full would use some cure. All he says Sneeze Miracle Drug and that's an important mentioned traveling to north. There are no miracle pills That's that's science fiction so we don't know if Clark will save the day him as some promising research but then there's some not so promising research that's old pot and postle of living in a pandemic and doing science on the fly at least with this drug though the way. Science is moving. It looks like we weren't have to wait too long until we get better data again and now for a little non corona virus content. Because we need it today bats and we know bats feels like corona virus content. But it's not he goes. Scientists carefully watched about forty bats in captivity for fifteen months and they noticed that these bats built very cute relationships with friends. Fast they would groom each other. Then they would scratch each other's backs and ultimately they became. Bff's that FF's they even started sharing food. The researchers said that no one had seen this kind of behavior before we just didn't know that bats boomed these kinds of friendships so they go bats friends and not just disease vectors that science passes and one more thing we have set up a voicemail to collect all of your questions about Corona virus or of your healthcare workout with a personal story. You WANNA share with US please. Call seven seven four four eight one one two three eight. This is an American number. Seven seven four four eight one one two three eight and leave us a message or you can always email us at science festivals science B S at Gimblett Media Dot Com haven. This is Wendy calling from science fasces. I remember when the our you doing. I'm dead you've had a gripe with last episode I did write to you. WanNa you WANNA school me. How do you do it? Waukesha is is the correct stern. Ation Waukesha Waukesha Waukesha. Wisconsin said correct. You from Waukesha Wisconsin. I am not from Waukesha. Wisconsin But I have lived in Wisconsin for about the last twenty years. You're you're pretty well placed to to know how to how to pronounce this city. Congratulations on having the world's oldest fossilized Scorpion in your neck of the woods.
"chloroquine" Discussed on Science Vs
"Welcome back we're talking about Clark wine and although we've been talking about this for ten minutes I had to clean something out with doctor. Matthew Poland is it Clark Quinta Clark. Quine kisses depends on on which? I think it's an aluminum out. Many of them type things just like the metric system over again we say chloropicrin typically. Why do we do this so In respect for you I will call it chloroquine again. Now that's settled we WANNA know. How could Clark wine chloroquine work for this corona virus? So I you have to know that. A virus wants to copy itself to make more tiny particles so that it can spread into more and more and more cells and to do that if I had to get into ourselves so it binds to what's called a receptor and that triggers. This process fell in just a little pocket. Infidel this process of getting ingested. He's cold in vaginal. Which is great is a great word in vaginal but was actually important him. Is that when a virus gets into that little pocket in our cells? The cell is like Hook that you you gotta go. It's tries to digest it a lot like our stomach shoots acid into itself to digest. Food is kind of what the cell is doing and so to get rid of this nasty virus. The cell will squeeze acid into that pocket but it turns out this strategy backfires because the corona virus it actually wanted the cell to shoot the acid all along you saying the virus needs acid to reproduce to get more virus particles correct. Yeah Yeah Kinda taking advantage of a self defense mechanism this. Oh has that's very raid. Yeah very rare. He is where our old pal? Chloroquine comes into the mix. We think that it tells cells. Stop at with that. it steps in to put the brakes on that process or is it says. Alkalis was a raises. The Ph in this case. You want to be basic okay. So by slowing down this added thing and keeping the virus from copying it sells Clark win could delay the spread of the virus. In Your Body Cal Satchel. A professor at northwestern described it to us like this anything that slows down. The cycle of one virus mix one hundred. One HUNDRED MAKES TEN THOUSAND. Can thousand makes a million anything you can do to slow? That down gives your body. Time to mount this immune response Clarkson is thought to do some other stuff too like damp down inflammation which is a big part of why these corona virus makes some people so sick. Okay so that's how research is think chloroquine might stop this virus but does it actually work..
"chloroquine" Discussed on Science Vs
"I think they were driven by a understandable fear. And worry this is Matthew Polen. He's a doctor. An infectious disease specialist at the University of Minnesota. I think fear in the situation is understandable. Very uncertain tying with you know not a lot of good options and a lot of situations But you know as a clinician I like that I I feel for them at eight. That had happened to them. And I wish it had matthew is part of a team in the US. That's running clinical trial into whether chloroquine can help people with rhinovirus and he says that we know when people take chloroquine at high doses. Which is what this couple took. This chemical can be dangerous. They were taking. You know many many kinds more than the recommended amount. Then that's his people take chloroquine at lower doses all the time for malaria and then the main side effects stomach troubles like nausea and also headaches. Some people also get itchy over their body. But generally at low doses. This drug is thought to be safe. Matt his taken it to prevent malaria and he's also giving it to patients for mean diseases. You know it's a drug I I've personally prescribed it. Probably a hundred times you It's very very safe. I've never had anyone that had adverse effect hermit taking a chronically. The upshot is that dosage is super important. Clark Line is not something that you want to be self medicating with but at the right dose for short periods it can be safe big question though. Kennett actually help. People with Corona virus is coming up just after the break..
"chloroquine" Discussed on Science Vs
"Welcome back so chloroquine is making a lot of headlines. Right now what is it well? It's a drug. That's been on the market for decades. It's often used for malaria. And it's all people have been taking it for around seventy years and there's a few different kinds of this drug like hydroxy chloroquine. That's used for diseases like Lupus Clark. Wine has been hanging around fees but this week. The story of this drug took a bizarre Tan. Hello Hi can I speak to Daniel Consumers? Dan is a professor of toxicology and the medical director of the banner. Poison and Drug Information Center in Phoenix Arizona. People call his hotline when they're worried been exposed to something toxic to retake calls from from people junior with contribution exposures rattlesnake venom ations rattlesnake. Yup that's the second one he said. Yeah we get We get like about eighty five rattlesnake patients year the recently him something else has been rattling. Dan as the corona virus started to spread in the. Us Stan was getting worried. That people would take matters into their own hands and start using homespun treatments. Dr Google to cure all they coughs and fevers happens of times before I mean you know we just see. We've seen this with Influenza WHEN WE'VE had bad years with influenza and you know we've seen this over and over again yeah dances for the flu. People will try all sorts of stuff and in this pandemic. He says people wait even calling his poison centre to see if they should take blake to avoid getting sick with this corona virus. And so we just knew when as more and more things were being promoted to our he'll prevent so we just tried to get out and warn people. Last Friday dance team reached out to some medium to try to get the would out about this so we release that unfortunately within forty eight hours. We had our first. You know our our prediction true. Dan's poison symptom got a coal from a couple in their sixty S. This had heard all the excitement around chloroquine including what trump was saying about it and then the concerned about some vague symptoms. They interpreted have been for Cologne virus. Jimmy like a sore throat or cough. Something like that correct for interesting. And it was only the husbands became concerned about it and they decided good They may be able to prevent or treat krona virus with a home product that continue chloroquine the woman involved talked to NBC about what happened. She said that she saw this stuff in a pantry. That had Clark wine in it. It was something that she used to keep fish healthy.
"chloroquine" Discussed on Science Vs
"Wendy Zuckerman. And you're listening to science fastest from Gimblett as this carpet nineteen pandemic rages on we assign specimens have been keeping an eye on all the treatments. Dr Trying around the world about a month ago we told you about some promising research out of China into an anti malarial drug was pretty obscure back then but just this week. It felt like the drug had been upgraded to celebrity status. Thank you very much at my direction. The federal government is working to help update large quantities of clerk win chloroquine. It's the drug that's making the headlines and trump is a big fan in one press conference this week. He said that he'd heard the story of a man who took it and had a remarkable recovery. A gentleman they thought he was not gonNA make it. He said goodbye to his family. They'd given him the drug just a little while before but he thought it was over his family thought he was going to die and a number of hours later he woke up felt good and he woke up again and he felt really good and he's in good shape and trump said that this drug might be able to help lots of people. There's a real chance I mean again. We don't know but is a real chance that it could have a tremendous impact. It would be a gift from God. If that worked. It would be a big game changer. And people all around the world to really latched onto this idea that this drug could help fight. This corona virus Google searches for sword. Some pharmacies saying that demand for the drug has skyrocketed and one company told us that it hospitals orders were up three thousand percent but when some people went looking chloroquine it took a doc Tan. They thought a drug could protect them. From Corona virus. But he and his wife made a terrible mistake. A couple ended up in this hospital after they each took a teaspoon of an old aquarium product. They had it contained chloroquine. So is the struck a danger or a gift from God today on the show. What's going on with chloroquine? We speak to a scientist running clinical trial into this very drug and corona virus. Right now and we'll find out. Does it really have the chance to be a game changer? In this pandemic when it comes to this corona virus there is a lot of talk of a gift from God but then their science.
"chloroquine" Discussed on KNST AM 790
"Chloroquine chloroquine effective antiviral therapeutic treatment and a vaccine against the wall hung virus the use of clerk when tablets are showing favorable outcomes in humans infected with the virus clean faster time to recovery shorter hospital stays our own CDC research shows that caloric Quinn also has strong potential as a preventative measure against them excuse me against the virus in the lab while we wait for vaccine to be developed Clark one is an inexpensive globally available drug it is been a widespread human use since nineteen forty five against malaria autoimmune in various other conditions how many of you may have autoimmune disease or weakened immune systems you might have Crohn's disease you might have other chronic diseases you might of Addison's disease you might have rheumatoid arthritis you all know what I'm talking lupus you might you all know what I'm talking about and there's many others our CDC and the World Health Organization of not published treatment measures against corona virus to the media completely ignore this then I had a follow up question there's a statement put out some of the press some of the opposition party the president that the president doesn't follow the sciences the president following the science Sauchie every single time and by that I mean almost every day it's not like once a month when the task force meeting there's several of us myself included I'm not the only one that's a scientist a public health person there are other people who have other responsibilities so we get a good sampling of expertise that you need and it's led by the vice president sector AA's ours there's secretary of HHS we talk about every aspect we make all of our decisions and recommendations that are based on the science I have never in that room had a situation where I said scientifically this is the right thing to do and they don't do it I scientifically this is the wrong thing to do and they did it anyway then we get up and we presented to the president and he has a lot of questions that's his nature he's constantly asking you questions and I never in the multiple times and I've done that what I said for scientific reasons we should really do this but he hasn't said let's do it when he's decided not to sided when he suggests why don't we do this and I say no that really is not a good idea from a scientific standpoint he is never overruled me this is been put to bed now now I have to say I'm like Dr Satcher who's really I I'm very impressed with the man some conservatives Adam now is a liberal I'm very impressed with the main but he's not looking at the full horizon of events he's looking at his expertise the present the United States has the look at everything if we have a dissolution of the civil society that's a problem that's not felt she's job that's not any of the medical experts John if we have massive unemployment that affects our ability to even run a third class healthcare system that has to concern at present in the United States if we have such massive unemployment and we have other consequences violence massive depression suicide other things that fill up our hospital rooms and so forth that's something the present the United States has to decide he's not elected to be a robot who simply takes in what this doctor that doctor says and then marches along it's his job to make the tough decisions which is exactly what he's doing but the media constantly constantly trying to do have these men at each other's throats really is is is so disgraceful so appalling I I really don't believe these people in the media understand how much they are hated and hated for good reason not because the president because then the enemy of the people but because they act like the enemy of the people I'll be right back van the firm our it.
"chloroquine" Discussed on KIRO Radio 97.3 FM
"Has died after taking chloroquine phosphate believing that it would protect him from getting corona virus the man's wife also took some of the pills she's now hospitalized she told NBC news that she had watched president trump tout the potential benefits of Cork wine was the chloroquine a drug is used to treat malaria in humans you see the president's press conference where did you hear about yeah we probably started coming about a month actually and then what and then what did you did you seek out or clean out what are you going to finish okay the former clerk we that she took is used to kill parasites in quay fish courses toxic to humans the couple in their sixties they're worried about being higher risk so they mix the substance with a liquid and drank it and went within twenty minutes they got really sick and unfortunately her husband did not survive the one thing that I am not going to do I'm I don't care if you don't like what I have to say or not I'm never going to sway away from hoping in helping people not die and not being the situation when you have bad messaging that goes out to people those type of things happen and so I hope that that doesn't happen again we just come out or someone comes out and says this is what you could take and we're looking into this doing it when you do that people cling to that people cling to hope I know when you cling to hope we all find out exactly so when you when you when you do that you say oh man let me go ahead and try that medication yeah and yet right now well I mean yeah in that case it was it sounded the same but it was a completely different form it was toxic and right now again it you know if you're gonna listen to anyone always listen to the medical experts at it when you're talking about any sort of hill or anything that you're gonna possibly take to try to stop coronavirus which of course if we knew what would do it we wouldn't be in the situation for immediately after governor Insley issue that stay at home order last night king Pierce and Snohomish county sheriff's department quickly announced that they're not going to be issuing tickets are arresting anyone Pierce county detective ed Troyer says deputies gonna take an education approach if they spot band gathering shall have the option of saying Hey this isn't a good idea but it's not a mandatory order so we will not be enforcing it at this time AS or any type of ramifications for anybody's going to actually be cited court will be no time or will be taken anybody to jail city of admins taking a much tougher stance sergeant Josh McClure says they will hand out misdemeanor tickets if it comes to that reinforcement of this will be reserved for rare rare times that communication and education just ineffective and said that there's a lack of voluntary compliance shin soo much tougher stance because they're just kind of going one step further saying we would possibly do a misdemeanor ticket let's just not get it to that point you're looking at me that I was just trying to see where you're going yet let's not don't don't wait till someone has to tell you not to gather in a park like what happened last weekend at cal Anderson park would you be okay with people getting tickets like I've been severest tech it's like like here's a five hundred dollar ticket for you not I'll be flying at least what the threat of one yes at this point I would do yes I I I definitely want that hundred percent wanted to that well again we go back to if there is no ramification if there's no you know if if there's nothing that's going to happen what is the incentive right I mean you would hope that people will just do it for the greater good of all for a while we are all worried about what we need to do in this pandemic one big question for the courts G. is what do you do with all the people in jail public health experts say you have to reduce the number of people behind bars to prevent jails and prisons but from becoming the epicenter of the outbreak in already almost every state Supreme Court in the country has issued an order to scale back on judicial operations in order states hi court has gone the furthest at basically saying that judges have to release suspects accused of misdemeanors in minor felonies until they can go to trial or resolve the case okay so free show this morning during our meeting I was ready to put Ursula not seek out and I'm gonna ask you in front of all the listeners okay are slow tell me what your plan would be in it Ursula stars to kind of talk a little bit not so well let me show you are slow and then I start to talk a little bit more highly I realized something oh boy this is very complex and what I mean by complex with complex what would you do if you are in charge one of the leaders for the department of corrections and you'll know that there is a good chance that there could be a wide spread with the court the covert nineteen amongst your inmates what's already happening so what do you do so who and if you're gonna be releasing people who do you're only selling the easy one was okay no one who is accused of a violent offense I think we both agreed on that right it was like beyond that well don't even try it we try it there's no wind I just want to say I'm not I'm just not qualified enough to be able to speak on it is sure there are gonna be people much smarter than us so they're going to say this is what you with it so we want to hear from that from you if if you have an idea of how you would handle it if you were in charge of the prison system Texas okay ones we're talking about the extra time we now have at home you might be tempted to spend even more money ordering stuff like fancy sneakers from Amazon thank you I don't know I didn't I didn't order but go ahead but don't expect any same day deliveries or any anything close you could be waiting a month or more because of Amazon is focusing on delivering critical medical supplies and household stuff to its customers during the pandemic stuff like baby formula sanitizers medical supplies that kind of thing so your month I never thought that we'd be in a situation where Amazon where the that prides himself from one in two day deliveries now you're almost a month out for some of these things yeah hi but I are you gonna be able to cope G. what do you mean it was a accident I for I forgot for a second I think this is a good thing especially for you Gee I mean if you have to wait a month to get something that you think this will curb some of your impulse shopping thank you.
"chloroquine" Discussed on Newsradio 970 WFLA
"Stations check check check all right so yesterday we were talking about she said add the jet of others and we told you about this how do you say it still because I I don't hydroxyl chloroquine high to hydro oxy caloric Quinn Hey Joe I could never pharmacist or queen I think it's a dryer leaving a broadcaster can you mend it what is it hydra hydroxy floor Quinn give me a bottle that hydroxy Gloria guid right out of a jet has a hydroxy clerk okay so all right so this is a this is a drug that we've been using for malaria and apparently the malaria drugs give you some could quite of quite a wild ride a fever dreams I'm imagine malaria also gives you that but this stuff is like really bizarre and you're supposed to combine it with a Z. pack now I reached out to my doctor and my doctor you know is not insane and he just started to look into this and he's like look I all I all I did was just look these up to see if you know other dangerous side effects with these two medicines together and he said well one one of the risk is a potentially dangerous heart rhythm ended that's the side effect of the hydroxy glory could address hydro crews hydro lucks hydro click that drug I get a call at H. Q. from here that drug barely you can you can make your heart to do things that it probably shouldn't and according my doctor he wrote I'm not sure how often this arrest mia Curtis I'm sure depends a lot on how high it does use a purse prescribed for the hydro the close of glory quick or the zithromax it also depends on what medicines a person might be on in the heart history and blah blah blah it's like I'm I'm not a I'm not a hard guy but he's reaching out to somebody to find out he said the textbook says that maybe it should but these two together even if the cure rate for the Chad the latter is in the French study is one hundred percent my doctor said if you get this are not I don't feel comfortable prescribing both of these medications together it's like I gave you the hydro drug to call it quits by itself if you get it and it may be in our lives I throw in the Z. pack but I don't feel comfortable prescribing both of those together so there's the news from my doctor still there you're not getting that anywhere else Chad check the do you take that stuff still would you take if you have that would you try in that not just for fun another to recreational situation but if I'm on the phone on us death from corona virus yeah I'm gonna pop pretty much any yeah I mean I find in there here's what I'd like to know what is the difference between this and people who have cancer well I we got it what about the Jetta has got it so we'll make everything available you try if you want to eat a broom stick if it works will lay a big group sticks available how come they doing it now but they won't do it with cancer well I think that's because actually if I've got cancer in your like I want to try it I'm going to die I'd like to try it that's the right to try debate that actually trump has advanced right in the right direction it during his presidency so to yeah so I I you know they've been able to kind of get some freedom for people who are in those circumstances to kind of just try something even if it's experimental this situation though is is even more rushed right like these things are happening so fast that is one of those things where it look if this is has the potential and there is a two a study as the guy put out yesterday forty people in a small study in France where it was very very effective it's one hundred percent effective yeah it's been rumored to be effective you know in other countries as well this dude the rumors that China and South Korea had used this at some level we don't know all the facts but you got to give people a chance if they're on their death bed you know you gotta go forth note of where where was it Jaida.
"chloroquine" Discussed on KXNT NewsRadio 840 AM
"Report by techcrunch dot com and the results found early evidence the combination of hydroxy chloroquine which is a popular antimalarial drug known as planet of black window and the antibiotic azithromycin could be especially effective in treating colon nineteen and reducing the duration of the virus in patients the researchers apparently performed a study on thirty confirm it called in nineteen patients and treating each with either hydroxy Clorox Clark Wade on its own a combination of the medicine with antibiotics and a control group that received neither the study was conducted after reports from tripling of Chinese patients indicated this particular combo advocacy and shortening the duration of infection it makes included in the study included sixty showed no symptoms twenty two what symptoms in their upper respiratory tract like sneezing headaches sore throats and eight we should lower respiratory tract symptoms like coughing twenty of the thirty participants in the study did receive treatment the results showed that when combined with is it from my sin eye drops the floor clean was it really affected by significant margin like much more effective than anything else now these are very limited studies obviously with a small number of patients but this doesn't show promise president trump today was announcing all this now the FDA says not approved yet so trump is getting ahead of himself a little bit in announcing it with that said obviously there is some hope that there will be some sort of medical breakthrough that will mitigate the effects of this thing now with all that said what does the long term outlook like William Leonard Joel Achenbach Carolyn Johnson Ben Guarino over the Washington post a piece today about this when Jason Christie chief of pulmonary medicine at Penn medicine that projections on hammock road varies patients might soon be flocking to Philadelphia hospitals if not physically ill he's my front line providers we're speaking about in the situation report that night there was this crack is how quickly the surge over one the system forcing doctors make impossible choices which patients would get ventilators and beds which would die they were terrified in those best case scenario experts around the country been churning out model after model marshalling every tool for mathematics and science in history and try to predict the coming chaos unleashed by the new coronavirus and make predictions what happens next depends really on everybody staying home in the worst case scenarios according to the study's America's on project record one point one million deaths I find it very difficult to believe we're gonna suffer at one point one million deaths if that is true it's over the course presumably of years now the model that says one point one million deaths in the United States invasion sick people pouring in hospitals overwhelming makeshift beds in parking spot parking lot tends doctors having to ration care charges a flat one frontline clinicians now again that it seems like the least likely scenario at this point given the fact that we are taking fairly aggressive steps across the United States if Americans do embrace drastic restrictions in school closures because he the death toll closer to thousands of national sigh of relief as you prepare for a grueling but surmountable road ahead now the big question here is how fast the government can ramp up production and they're not being very clear about that the reason they're not being very clear about that is because either they don't know and they've been slow on the uptake or they're not sure at what point the production exceeds the infection rate and we just don't know because again the testing has been very slow here so lack of test is meant it's hard to actually see how fast this thing is going to peak now there is some good news from inside the United States Nate silver has been following day by day the number of diagnoses in for example Washington state in king county for example which is Seattle the number of infections detected by day starting on March eighth twelve thirty three seventy four forty four thirty six fifty eight sixteen thirty two sixty eight thirty forty four that seems to suggest that this is not skyrocketing in Seattle in Washington state which is in the the chief number of deaths and sixty eight seventy deaths new cases per day starting on March eleventh one of five seventy one twenty one eleven seventy four one twenty seven one thirty five one awaits we're not looking at the end of this thing by any stretch of the imagination Ross and I'm seeing exponential growth in Seattle which is great I mean that that is a start it's a it's important that this thing starts to level off before it starts to decline with that said the possibility of a second curve here is what people are worried about that even if we flatten the curve that want to let people out of isolation this thing comes up that is why it's important to the government get all of its ducks in a row here six S. according to The Washington Post means a longer fight against rotavirus sent a clear whether Americans would be willing to endure harsh restrictions on their lives for months let alone for a year or more the answer is probably not which is why it is really important to increase the number of beds available adopting some mitigation strategies to.
"chloroquine" Discussed on KLIF 570 AM
"By techcrunch dot com and the results found early evidence the combination of hydroxy chloroquine which is a popular antimalarial drug known as planet of black window and the antibiotic azithromycin could be especially effective in treating colon nineteen and reducing the duration of the virus in patients the researchers apparently performed a study on thirty confirmed until the nineteen patients are treating each with either hydroxy Clorox chloroquine on its own a combination of the medicine with antibiotic and control group that received neither the study was conducted after reports from tripling of Chinese patients indicated this particular combo advocacy and shortening the duration of infection it makes included in the study included sixty show no symptoms twenty two what symptoms in their upper respiratory tract like sneezing headaches sore throats and eight we should lower respiratory tract symptoms like coughing twenty of the thirty participants in the study did receive treatment the results showed that when combined with is it from my sin eye drops the chloroquine was it really affected by significant margin like much more effective than anything else now these are very limited studies obviously with a small number of patients but this doesn't show promise president trump today was announcing all this now the FDA says not approved yet so trump is getting ahead of himself a little bit in announcing it with that said obviously there is some hope that there will be some sort of medical breakthrough that will mitigate the effects of this thing now with all that said what does the long term outlook like William Leonard Joel Achenbach Carolyn Johnson Ben Guarino over the Washington post a piece today about this when Jason Christie chief of pulmonary medicine at Penn medicine that projections on hammock road varies patients might soon be flocking his Philadelphia hospitals if not physically ill he's my front line providers we're speaking about in the situation report that night there was this cracked they saw quickly the surge over one the system forcing doctors make impossible choices which patients would get ventilators and beds which would die they were terrified in those best case scenario experts around the country even turning a model after model marshalling every tool for mathematics and science in history to try to predict the coming chaos unleashed by the new coronavirus and make predictions what happens next depends really on everybody staying home in the worst case scenarios according to the study's America's introductory toward one point one million deaths I find it very difficult to believe we're gonna suffer one point one million deaths if that is true it's over the course presumably of years now the model that says one point one million deaths in the United States invasion sick people pouring in hospitals overwhelming makeshift beds in parking top parking lot tense doctors having to ration care charges a flat one frontline clinicians now again and it seems like the least likely scenario at this point given the fact that we are taking fairly aggressive steps across the United States as Americans to embrace drastic restrictions in school closures we could see the death toll closer to thousands of national sigh of relief as you prepare for a grueling but surmountable road ahead now the big question here is how fast the government can ramp up production on there not being very clear about that the reason they're not being very clear about that is because either they don't know and they've been slow on the uptake or they're not sure at what point the production exceeds the infection rate and we just don't know because again the testing has been very slow here the lack of test is meant it's hard to actually see how fast this thing is going to peak now there is some good news from inside the United States Nate silver has been following day by day the number of diagnoses in for example Washington state in king county for example which is Seattle the number of infections detected by day starting on March eighth twelve thirty three seventy four forty four thirty six fifty eight sixteen thirty two sixty eight thirty forty four that seems to suggest that this is not skyrocketing in Seattle in Washington state which is in the the chief number that's in sixty eight seventy deaths new cases per day starting on March eleventh one of five seventy one twenty one eleven seventy four one twenty seven one thirty five one awaits we're not looking at the end of this thing by any stretch of the imagination Ross and I'm seeing exponential growth in Seattle which is great I mean that that is a start it's a it's important that this thing starts to level off before it starts to decline with that said the possibility of a second curve here is what people are worried about that even if we flatten the curve that want to let people out of isolation this thing comes up that is why it's important to the government get all of its ducks in a row here six S. according to The Washington Post means a longer fight against one of my wrists and clear whether Americans would be willing to endure harsh restrictions on the line for months let alone for a year or more the answer is probably not which is why it is really important to increase the number of beds available adopting some mitigation strategies to slow the pandemic on the.