22 Burst results for "Vincenzo"

"vincenzo" Discussed on Italian Wine Podcast

Italian Wine Podcast

05:50 min | Last month

"vincenzo" Discussed on Italian Wine Podcast

"This is the italian. One book muncie. Wouldn't my guest. Today is andrea vincenzo. Who is the expert manager of an estate capuano. Worry burma's yours. i'm with afternoon. The state is in the curtain prominence in the carberry jump which is in the south perfectly more specifically we are on the hills overlooking there in which is a little foundation grondona and we over there. Yon- you're you're in a very very beautiful spa. I n view. It's very nice. Yeah so what about the The vignon today overlooking the sea as well when yes. The geographical situation vineyards is very is very interesting. Actually do the you can basically go from somewhere where you could ski to someone where you cool the take off in the scene in like one hour of upper bribing heating and this. This can the results in interesting situation as far as winemaker here there. There is a difference from the temperature of the day the temperature of the night. You're not n this means that the grape can mature very quickly and arrive harvesting. I'm very quickly and the the breeze from the sea. That is john. Malott for the hillside and this removes humidity from the rain and the skills mall than bacteria and other dangerous agents and the semantically. Very good good location or provenience envy's in this kind of ambiguity for this profession. The family history them on the tomato finally is three. Ism actually goes back several centuries they did they move. They can carry these lands for regenerate for empire generations. But the the the they're started the day. Y m mother. Certain wines are around off way. Through this non reds there is actually elector in the family archives wherein the cardinal of amalfi yet throw couple rights to brother views and the end the family forms me ending firms in us. Brother i ask you for that fine nectar at his sunday himself as asked me off so Selective hoping south was asking for the local wines..

andrea vincenzo capuano burma john amalfi us
"vincenzo" Discussed on Set Lusting Bruce: The Springsteen Podcast

Set Lusting Bruce: The Springsteen Podcast

04:17 min | 5 months ago

"vincenzo" Discussed on Set Lusting Bruce: The Springsteen Podcast

"But like i also learn to appreciate maybe different types of of Approaches to creating music. So i've been into some really Really intense electronica stuff michael. So i'm not maybe not so much of a lyricist like that wall of sound like when Here's a popular canadian artist. Dead mouse right. You know he he. A lot of people would classify stuff as dub step or whatever being a software guy myself. I like the idea of music and computers right. Yeah like there was a time when the guitar was like top level technology. Sometimes we think music only has to be. Sometimes people think music has to be played on ancient technology. Yeah but you know if we're looking into the future technology the instruments of tomorrow are not gonna be maybe string made a string of would be made a bits and bites right. Yeah i i think right like And i know sometimes synthesizers are called you know have a bad rep because of you know. Eighties nineties pop. But there is a electric keyboards and computer. Work is amazing. What you wanna hear my other lay no to sure mongolian throat. Singing okay dow. You're doing a bit no not a nice okay. So here's the thing. I'm eclectic like that. I like the. I like the idea of being both lanes at one time. That's kind of a big. That's a big thing about me is all the posing things in my head. I think it makes me a better person absolutely and so mongolian throat singing. There's a there's a band called the hunter to and if you're on youtube right now you can search up. search hon. her to do your best to to phonetically. Yeah correct you live at google. Google campus will be treated to a concert like no concert. You've ever heard and the sounds. These ancient sounds these gentlemen are making are like they don't even sound like they belong on this on this earth but then you also feel connected to it because it's the sound of a voice live in berkeley. That's the one you know. What put your earphones on. Close your eyes and just listen to it and it'll be enough i. It'll be jarring and weird weird but he just lead into it and then it'll it'll take you somewhere interesting friends. That is great. Yeah So punch-up podcasts. Are you on twitter twitter. You can follow me on twitter at at l. k. underscore who h. u. n. a. I started my twitter before. I ever launched a youtube channel. If i could go back in time would change it. You'll do twitter but that's my twitter l. k. Underscore houna icu. All right. i will include that Michael this was so much fun. I appreciate it I will find an excuse for us to talk again. you are. You're a great person and as we get through this together You know one of the joys of podcasting as you talked about is is connecting to people..

Michael twitter youtube michael both lanes google one time tomorrow Eighties nineties Google campus berkeley canadian one earth
"vincenzo" Discussed on Set Lusting Bruce: The Springsteen Podcast

Set Lusting Bruce: The Springsteen Podcast

03:17 min | 5 months ago

"vincenzo" Discussed on Set Lusting Bruce: The Springsteen Podcast

"Show. How are you doing my friend. I'm doing great. Thanks so so much this is. This is a blast. Love what we did so first off. Tell them about your podcast. My friend so you know what i the. My podcast started as just an avenue for people to work with me on my comedy. Material turned out that. What really like to do is to have conversations with cool people and one of my one of my guests and actually talking to talking to you. Jesse is help me. Get over my initial hump. You know that initial fear that you feel. Yeah you were such a. You're such a great and gracious and engaging guest that That i wanted to meet more people like you. That's very sweet of to say what was really interesting is You know michael reached out and he says hey I'm booking x. amount of time but we don't have to do it and we ended up staying the whole time. We had such a good conversation. What if you just open yourself up to meeting people and having their experiences. And that's what my podcast is all about. It's punch-up podcast Maybe jesse put a lincoln the duly do well but all i want is to make a make friends and make friends or fans like one time i want to have conversations with people and you know world kind of stuck in this pandemic right where we're having less meaningful social interaction and right now. I'm having the time of my a meeting so many cool people in love to meet you. Well i appreciate it i. I am looking forward to some time where we can meet in person show of exchange of beverage and and talk stories. And i'm welcome. You're you're welcome my skinny podcast anytime and i'd love to come back So to pull the curtain back a little bit. I've been thinking about doing a of noxious springsteen fan podcasts. And i was like. It'd be fun to do it for april fool's day and so i reached out and michael said. Look i don't know about a lot about bruce but i love doing improv. So talk to me a little bit about why you were willing to help me out well first of all like you right. Yeah and unlike doing favors for friends and just comedy stuff is always my lane yell goofy goofy that way and i'm like he said obnoxious i'm looking to you have an obnoxious fan. And i'm like listen. I don't know much bruce springsteen. That's good while i've got you do. What kind of music do you listen to michael. What are you love okay. So maybe i'll get a little bit weird for your base. I like so. I like so music to some people like they dig into an artist but sometimes music strikes me Where i am in my life at the time. And sometimes i use music is sort of like touch points to go back in time right. Yeah if i want to feel the way. I felt in high school. You know listen to some spin doctors.

bruce springsteen michael Jesse april fool's day first one bruce jesse springsteen one time one of guests
"vincenzo" Discussed on Set Lusting Bruce: The Springsteen Podcast

Set Lusting Bruce: The Springsteen Podcast

02:25 min | 5 months ago

"vincenzo" Discussed on Set Lusting Bruce: The Springsteen Podcast

"Oh my you know my heart to god ice. He would have never left that town. If mary got in the car with him they would have. Maybe went to the edge of town right. But like the thing that propels you to greatness. You can't do it with dual with someone else has their needs. You'd be selfish. You gotta you gotta get enough delta v to break the break the gravitational pull of. What is that right. yes. Mary stayed married. Didn't a car didn't get in the car. That's that door closed. And he drove oi. Wow that's a good answer. That's a solid answer. I appreciate that any. That's i appreciate you sharing a get wise in my old age. I get that you know you. You seem to be very grounded soon. More grounded than me. all right. i mean that the our guest final words so my listeners. Listen i just want you to know that. Like just like just like the bus went through tough times. You probably going through some tough times too but just you know just work hard. Keep those clean in. Put it all out there and you and you're going to achieve your dreams. That's all i got that. That's a beautiful. That's a beautiful. I appreciate it any Vinnie alfonse. And i just appreciate you so much listeners. You stay safe. Remember to wash your hands. Remember to social distance. Remember to wear an f. in mask and take care of yourselves. We'll talk to you soon. Thank you to my patrons who helped support the show. It is greatly appreciated. I wanna thank. Betsy hodges leave al petri elizabeth bronson stephen maglio holly mac steve rogers dale hosic. Terry smith anna lynne. Chris bloom and my first patron mary. Thomas thank you guys so much for all the love and support you give me a.

Vinnie alfonse Terry smith anna lynne Chris bloom Thomas dale hosic steve rogers stephen Betsy hodges Mary elizabeth bronson first mary v holly
"vincenzo" Discussed on Set Lusting Bruce: The Springsteen Podcast

Set Lusting Bruce: The Springsteen Podcast

05:25 min | 5 months ago

"vincenzo" Discussed on Set Lusting Bruce: The Springsteen Podcast

"He felt that you gave up your chance to meet him. A million guys ask for his autograph every year. But you know what he saw me. Give my spot. The little boy crutches gave me one of these. He remembers me. Okay remember me. Yeah what do you think versus legacy is going to be. Then he wrote. I think maybe the biggest legacy bruce's gonna leave is just. It's not even going to be as music is going to as muck on the american people. Okay you know what a thousand years from now people will be talking about born in the usa. They'll be referencing the boss but they don't even know they'll be speaking some unit code moon language that is not even the same anymore but they'll know who he is springsteen's he's gonna live forever. Yeah with as many shows as you've gone to like. I said hi hundreds. We're high okay of their ya. None i understand i understand. Is there any songs that why i guess. It's just easy to set. You've heard them all haven't you. I have heard him all you. What like i said. Even the worst one is better than anybody else's best okay right like the way it makes you feel jettison whenever wanna feel a certain way and i mean it's a good way or maybe a melancholy way maybe in a way that you're aware i just wanna quietly reflect on how hard i'm crushing it. Yeah no i listen to. Little springsteen makes me feel good and my heart. A lot of people felt like he betrayed us going to broadway tickets for seven hundred thousand dollars you know use. It sounds like you're a man of the people like your father but do you. Do you recommend. I mean he. He got a little taste. Right is that not is. Is that not the american way you know what though i thought long and hard about that. Okay i'm gonna sell a little morally inconsistent now. Okay i get it but you know what it just seemed like me like. He was just taking this chance to flee some fat cats okay. Maybe it's a different type. Accra maybe he was going gonna try to grab them people that far through silk. Like listen if you're you know it's like it's like a bartender in the town bar. Okay your local you just come in and drink your town you cover. I hear you. I get that. So that's what you think it was. That's what i think it was. So then he. This has been great. I i have love talking to you. Do you have any final thoughts. I'm honored. I'm honored that that you would ask me about my thoughts and i just want you to know that. Just want you to know. Bruce springsteen he speaks to he speaks to the soul of every american myself. Of course included. 'cause.

Bruce springsteen usa seven hundred thousand dollars one springsteen hundreds A million guys years american every Accra bruce thousand
"vincenzo" Discussed on Set Lusting Bruce: The Springsteen Podcast

Set Lusting Bruce: The Springsteen Podcast

03:34 min | 5 months ago

"vincenzo" Discussed on Set Lusting Bruce: The Springsteen Podcast

"He owns a gene vinnie. Yeah no it's like that guy you know. It's like that guy that that goes to a harley dealership and buys all the as usual dangles off but you know. He's no biker. Oh that's your thought you don't think versus in authentic. I think he probably does use four wheel drive but he probably does it when the pavements a little wet yeah. That's shocking man. Who's the guy's been rich as you know. The guy's been rich longer almost as long as i've been alive though i think that's a fair thought I i understood that you know. Things reached out to me as you said. You've got some little known facts that you think. My listeners need to know about purse will first buffalo. Here's a little no medical fact. About mr springsteen he was born with five testicles. Why four five testicles. No nobody knows. Today if he still has five testicles that seems very outlandish. Fantasy a lot of sense on the other hand though. That's why he's got so much much. Okay got so much. wow his. Maternal grandfather penn. One quincy was an italian duke. Who is noted for his gear. Lard large hats. I did not hurt this. And i really thought i knew a lot. About bruce digby okay. Okay there were large are huge tone. Jesse they're huge hats. Very big joe is like a nobility sign was like. I'm the grand man you know in the italian court. Well i do notice that. Bruce loves the wear cowboy hats right. So maybe that's just a that's from his jeans you know. Here's a little known fact. Everybody knows the fact that like he got drunk one day and decided to hop the fence. Graceland yes he got. He got the boot drive yes famous. He's doing this for years like he actually broke on graceland grounds like like seven times. Okay i'm sir. How did this every so well. Because in two thousand thirteen he settled with the estate after returning a solid gold day which was the matching birthday to the toilet. Elvis died now. You're saying that. Bruce springsteen broke into graceland and stall a solid gold day. Oh yeah because like he was a big joke. I'm rich. I'm bruce springsteen again away with anything like the cut him when he was young but you know he's gonna keep me away from this. Wow i doubt now we keep it out of the so this before the internet right. Yeah that's true. That's sorta internet are celebrities. Get away with yeah absolutely yeah now the now too so like i said two thousand thirteen. They settled it with these date and he said like listen. I'm not a young guy. These these pranks are funny anymore. King is dead. Well you've been a fan of long time. have you ever got to meet verse. I had a chance to meet bruce. Okay i had a chance but there was a little boy in. He had crutches. See okay and the last spot you know was going to be like me but i saw the little boy crutches and he wanted me bruce been waiting for hours and so i said no you go ahead. You meet bruce and brunei. We we made eye contact and to give me one of these. You felt he..

Bruce springsteen Jesse brunei bruce springsteen Elvis bruce springsteen Bruce bruce digby Today seven times five testicles graceland one Graceland harley one day italian first buffalo four
"vincenzo" Discussed on Set Lusting Bruce: The Springsteen Podcast

Set Lusting Bruce: The Springsteen Podcast

03:57 min | 5 months ago

"vincenzo" Discussed on Set Lusting Bruce: The Springsteen Podcast

"It's cold that's cold. So what i hear you saying right is that that that bonds tarnish tarnish. Yeah and you know that we have that that family blood ties and then we turn yourself on family. you know. It must have hurt you well. Everybody's family does something that pisses enough sometimes right buddy. You know the people that hurt you the most of your family absolutely. Yes right if you know. If it didn't hurt they wouldn't be fem. I guess you got conflicted feelings about it and stuff. Yeah when you heard that they were getting back together and going to tour. Were you happy where you'll little bitter like. Oh finally you coming back you or talk to me a little bit about your emotions there. So i was very excited Here's the thing. How could you not be excited about this. Like you would be an idiot if if you could not be excited about the east street band again but like come on like. They're not the same a little older. Yeah maybe the music is. I don't know if the music is worse. It's just different. Yeah now you talked about that. In a lot of ways you feel like he peaked darkness in the town so like when western stars out which is kind of that country album or letter d you. Which is the brand new album. You know your first thoughts on those at this point at his age. Yeah we don't need to be like seventy years old. We're not looking for an experimental artists at this point. right right. remember. When garth brooks was chris gains for a bit and then everybody stop talking about. Yes we don't need that sort of name right. He's not like you to making like the zoo station album. It's you don't have to drift so far out of your lane. You have fans that have come with you this whole time. You have to drag him into something else. It sounds like you're not a fan of some of the later albums as you said it the kind of watered down. And you're saying don't try to reinvent the wheel right. Yeah like listen emphasis darkness on the town every release subsequent to that has been kinda like adding a layer stain right. Yeah it's it's it's making it a little bit dirty you can't you can't rule in the dirt and not keep yourself you i keep yourself clean. You know this metaphor but like you understand me right. I do i stand here. Yeah like when you make something pure releasing some trash just to make your fans tried out. It makes me lose respect so like you say you don't go to the ceiling of sixteen chapel and give it a facelift right. Don't go in there with your box of crayola. The master's already touched it. Michelangelo's work has been done. It's like that lady that went into the church in italy. Clean up the Clean the face of christ and then made it like a moosh. Yeah like a like a circle with the with the we. You know what i mean i know through that danny i. I almost hate to ask you this like okay. Where are you happy when he did the super bowl a few years ago of course of happy right like even the worst springsteen is better than the best of everything else. I don't get that. So of course i'm happy it's like i said i wanted something more with more edge to it but i understand that sometimes you gotta get paid. Your brother was getting paid that day. What do you think of the jeep commercial. Listen it's hard to by bruce springsteen as a jeep guy right yes come on like would you jeep around jersey. Well you know supposedly..

italy garth brooks bruce springsteen Michelangelo springsteen sixteen first thoughts chris gains christ seventy years old crayola few years ago release super bowl
"vincenzo" Discussed on Set Lusting Bruce: The Springsteen Podcast

Set Lusting Bruce: The Springsteen Podcast

05:39 min | 5 months ago

"vincenzo" Discussed on Set Lusting Bruce: The Springsteen Podcast

"That from a lot of fans especially longtime fans and you know it. It sounds like you're in are similar to aids. You know you you kind of found him. I assume you found him in the the middle seventies right like when he first started putting out albums you know. I assume like well. Where did you grow up in the east coast. I know you mentioned the east coast. Well see. I grew up in philly. You know but then we moved to new new upstate. New york no as older like syracuse rochester area. And so so bruce's just there for you. It is something about his music. it's it's something about. It's not one thing to say that you could just have one thing about bruce springsteen that that stands out to make like him means you're not really a boosting research bruce fan. You're not really bruce springsteen fan yeah because he's just he's everything is everything right he's the he's the full jewish. Oh okay very nice So i i always like to preface this. You know the amount of time she seen bruce's not fair barometer of how big of a fan you are but vinnie You know have you you Obviously you've seen him live. Do you have a count of how many times i've been blessed amid truly truly blessed. I've always been a hard worker. You know just like bruce so always being able to full you know a treat those i love right so i'd say if i was put a number on it. Oh we're talking hundreds okay. we're talking hundreds do you. Do you wanna brag. The door. Brag though no i understand who. I'm saying. Hundreds okay hon. Yeah okay okay. Stand each other. I just said. I understand exactly what you're saying. So you've mentioned that you've gone and seen him a couple hundred times or though i may be resting up. I wanna brag to boast. I know you're not that kind of guy right and you're gonna go. I am the most humble guy. I can tell that you know met jesse i see i see that you are there tours that stand out to you. When will you talk you talking about like that. The new the new watery stuff. Where you're talking about like you know late seventies. Prove all night that was..

bruce springsteen New york vinnie bruce jewish middle seventies hundreds philly first jesse hundred times Hundreds one thing east coast late seventies new new upstate syracuse rochester fans
"vincenzo" Discussed on Set Lusting Bruce: The Springsteen Podcast

Set Lusting Bruce: The Springsteen Podcast

03:53 min | 5 months ago

"vincenzo" Discussed on Set Lusting Bruce: The Springsteen Podcast

"To be honest. When i first got into the bruce it was because you this lady i was seeing at the time you know you know she would play this music. You give me right in the gooch. You know what i'm saying you know Born and run. It doesn't hit me as hard as like his early stuff. But i love the guy i love is town. I respect all his work but it was hard to save. I think he's just you track of my life. You know what i mean. Welcome to set less bruce. your podcast. All about bruce springsteen has music and mostly as fans. I am your host jesse jackson and joining me. Today is my new friend. I've been on the internet Vinnie al franz welcome to the show. It's it's great to be here with you in like listen it's vicenzo but that's no big deal happy to be here happy to talk about the boss. I'm so glad you're here. You know we met via twitter and we talked a little bit and it seems like you're a passionate fan. Nobody is more passionate than me seriously. Seriously when it comes to music to food to women on the most passionate on the most passionate a guy you ever met. I you know i. That is great. I always like the beginning. So where did you grow up. What kind of music did your family listened to. I grew up in a hardworking family and we grew up listening. Mom was was in the little richard. But you know. I i like the on the sounds of the you know the american work man right. Yeah people like my pops you know and and the bus you know. He invited all of that. What you're pops do for a living. He's a bus driver was a bus driver and he worked the night shift. Oh wow yeah so. I'm sure that he must love a lot of the guess. I see your cross yourself. You must be moved on gun wrestle. Listen pops I know you're looking down your of me today and you know 'cause i know great fantastic. Well i am glad to hear that So i thank you for letting me vinnie So i guess him driving nights right. You'd see him during the day. Do you were the classics. Was it sinatra was at bennett. Did you hear the little bit of opera. When you're grown up tony bennett. Just that taste the taste of it on my ears. you know. i wasn't so much. Not a guy. I always thought they had a bit of an a an attitude but Tony bennett that. That was a real man. Yeah i can imagine well So let's talk about like when. Did you discover bruce and can you. Can you talk about. Why is music kind of spoke to you. Well to be honest. When i first got introduced bruce it was because you know this lady. I was seeing at the time. You know she would play this music. Give me right in the gooch Born to run it doesn't hit me as hard like his early stuff. You know but. I love the guy. I love town respect all his work but it was hard to say. I think he's just you always the soundtrack of my life. You know what i mean. Yeah i know..

Tony bennett jesse jackson tony bennett bruce springsteen bennett Today today Vinnie al franz first twitter richard american vinnie bruce
"vincenzo" Discussed on The Curious About Cannabis Podcast

The Curious About Cannabis Podcast

07:45 min | 11 months ago

"vincenzo" Discussed on The Curious About Cannabis Podcast

"Absolutely. And for those listening that maybe don't have such a technical technical background on cannabinoids science. How would you describe the concept of the Endo cannabinoid Dome to somebody? Okay. So basically, you know with the word. Oh now we make new words containing the the the prefix the suffix off to identify very large system. So we have the Janome with the metabolism. We have the proteome and so on and so forth. So the Endo the endocannabinoid Ang Ang came in a way from you mentioned before the the study that roughly mechoulam in which we collaborating collaborated on the Entourage effect. So basically what we perceived is that in what we were measuring. In fact when we were measuring endocannabinoids is that this these two molecules and under minded to a g were accompanied by dog Plethora of other compounds and this compounds this metabolites were chemically and biochemically similar meaning that you know, an undermined into a Jeep belongs to you know, mm different families of metabolites. And these are the Ennis. I'll at the moment and the and the monocyte whistles some of which were already known. In fact, even one of two thousand kids, but even longer than that before the end of cannabinoids were discovered. So the nobody knew really how these molecules were acting so Rafi in a vegetative way that this is really is his main feature is creativity and Imagination thought about this. These are accompanying molecules that are there too practical to make make the two big actors look even more important than they are so it's an Entourage or you know, when politicians go around and they take with them a lot of birth. Of the accompanying people and that that's certainly part of the of the picture but that then we started realizing that these compounds in fact do have a molecules do have targets of their own. So the endocannabinoid if you wish is is a kind of evolution of the of the Entourage effect. Molecules like the NSA little minds or the Mona Lisa started being investigated receptors were being found and and this created of course exciting but also complications because you know, the pharmacologists ended the drug developers were the therapeutic drug developers were we're thinking okay, we can we can manipulate wage levels of the end of since they are so strongly involved in pathology. We can manipulate the levels of the endocannabinoids of an undermined and 2G in order to make more of these compounds where they're needed or to reduce the amount their amount where they're produced in an excessive that manner so you can do that by manipulating the the degradation of the biosynthesis of endocannabinoids, but then when it was found that and we found we and many others that and under might has the same biochemical Pathways as other in a salad all mines which have different receptors from the cannabinoid. Just this created a strong complication. We cannot really manipulate the levels of an endermite in this way without manipulating the levels of the other previously known as entering compounds but having an identity and and in the mechanism of action of independent from the endocannabinoids of their own so they can have been a dome is basically the the the bigger System including Napoleon undermine and 2G and their main receptors which are simply one CB2 but also bought some of the other receptors foreign under my tend to agree because these are two very promiscuous molecules unlike THC. This is one major difference from between between the endocannabinoids and the plants and and happy now it's dead or at least between between the endocannabinoid and THC and then it was found that in fact, even the biosynthesis and degradation of of these 2 khong Will not be only mediated by one or two enzymes there was a redundancy of biosynthetic and degrading enzymes and and sometimes it ingredient X will not degrade enzymes because they were simply converting an undermined and 2 g into molecules which had different receptors. And this is you know, this is this may seem strange but not two people like like me off at the bioactive lipids all their life, you know, all bye-bye activities are transformed into something different and come from something different with the different biological a month or so, and then there is the containers of an under my dental legited what we call the previously the Entourage compound which have their own receptors, even though they share with the endocannabinoid the same battle synthetical Pathways. And then finally there were other molecules which have different biochemical dead. Pathways as the end of cannabinoids better nevertheless, they're not congeneres. They're not like cousins not they're not like brothers and sisters but their cousins so you have a tennis I'll amide. And in fact when we collaborated with the and with with the with the other groups, we we found that in fact particularly with the group of my coworker the late my coworker. We we found that many many compound many amino acids could make a might with fatty acids and this could create an almost incredible number of new combinations between the 10 or 15 fatty acids and 20 amino acids. So just just imagine all the permutations and and so this compounds actually exist as as the group of other brands show as also recently investigated and and so it's really we're talking now about a huge number of chemical mediators. So the endocannabinoid open their containers their analogues, which may or may have not different similar biochemical Pathways normally have different receptors dead. We we talking about the several other targets that undermined into the G have Beyond City 162. We're talking about other enzymes. So we're talking about something something about more than a 250 chemical mediators more than fifty enzymes and and receptors and some of these receptors were actually known previously like the wage channels or the or the P bars and and and the interesting thing is that you know, of course we when the end of conversation became so big Then the next question was okay. THC is the only out of 100 and more a plan cannot be known that interact with the endocannabinoid system. What about maybe maybe if you don't look only at the end of can access them, but we look at the expanded n. Can have this Summit this and maybe the other cannabinoids with interact with the endocannabinoid home, even though they don't in fact with the entertainment system. This is true to a large

Endo cannabinoid Dome Ang Ang Aquino Janome Mona Lisa mechanism of action Equus physical exercise director Ennis Rafi
BTS #35 Excerpt: What is the Endocannabinoidome? w/ Vincenzo Di Marzo, PhD

The Curious About Cannabis Podcast

07:45 min | 11 months ago

BTS #35 Excerpt: What is the Endocannabinoidome? w/ Vincenzo Di Marzo, PhD

"Absolutely. And for those listening that maybe don't have such a technical technical background on cannabinoids science. How would you describe the concept of the Endo cannabinoid Dome to somebody? Okay. So basically, you know with the word. Oh now we make new words containing the the the prefix the suffix off to identify very large system. So we have the Janome with the metabolism. We have the proteome and so on and so forth. So the Endo the endocannabinoid Ang Ang came in a way from you mentioned before the the study that roughly mechoulam in which we collaborating collaborated on the Entourage effect. So basically what we perceived is that in what we were measuring. In fact when we were measuring endocannabinoids is that this these two molecules and under minded to a g were accompanied by dog Plethora of other compounds and this compounds this metabolites were chemically and biochemically similar meaning that you know, an undermined into a Jeep belongs to you know, mm different families of metabolites. And these are the Ennis. I'll at the moment and the and the monocyte whistles some of which were already known. In fact, even one of two thousand kids, but even longer than that before the end of cannabinoids were discovered. So the nobody knew really how these molecules were acting so Rafi in a vegetative way that this is really is his main feature is creativity and Imagination thought about this. These are accompanying molecules that are there too practical to make make the two big actors look even more important than they are so it's an Entourage or you know, when politicians go around and they take with them a lot of birth. Of the accompanying people and that that's certainly part of the of the picture but that then we started realizing that these compounds in fact do have a molecules do have targets of their own. So the endocannabinoid if you wish is is a kind of evolution of the of the Entourage effect. Molecules like the NSA little minds or the Mona Lisa started being investigated receptors were being found and and this created of course exciting but also complications because you know, the pharmacologists ended the drug developers were the therapeutic drug developers were we're thinking okay, we can we can manipulate wage levels of the end of since they are so strongly involved in pathology. We can manipulate the levels of the endocannabinoids of an undermined and 2G in order to make more of these compounds where they're needed or to reduce the amount their amount where they're produced in an excessive that manner so you can do that by manipulating the the degradation of the biosynthesis of endocannabinoids, but then when it was found that and we found we and many others that and under might has the same biochemical Pathways as other in a salad all mines which have different receptors from the cannabinoid. Just this created a strong complication. We cannot really manipulate the levels of an endermite in this way without manipulating the levels of the other previously known as entering compounds but having an identity and and in the mechanism of action of independent from the endocannabinoids of their own so they can have been a dome is basically the the the bigger System including Napoleon undermine and 2G and their main receptors which are simply one CB2 but also bought some of the other receptors foreign under my tend to agree because these are two very promiscuous molecules unlike THC. This is one major difference from between between the endocannabinoids and the plants and and happy now it's dead or at least between between the endocannabinoid and THC and then it was found that in fact, even the biosynthesis and degradation of of these 2 khong Will not be only mediated by one or two enzymes there was a redundancy of biosynthetic and degrading enzymes and and sometimes it ingredient X will not degrade enzymes because they were simply converting an undermined and 2 g into molecules which had different receptors. And this is you know, this is this may seem strange but not two people like like me off at the bioactive lipids all their life, you know, all bye-bye activities are transformed into something different and come from something different with the different biological a month or so, and then there is the containers of an under my dental legited what we call the previously the Entourage compound which have their own receptors, even though they share with the endocannabinoid the same battle synthetical Pathways. And then finally there were other molecules which have different biochemical dead. Pathways as the end of cannabinoids better nevertheless, they're not congeneres. They're not like cousins not they're not like brothers and sisters but their cousins so you have a tennis I'll amide. And in fact when we collaborated with the and with with the with the other groups, we we found that in fact particularly with the group of my coworker the late my coworker. We we found that many many compound many amino acids could make a might with fatty acids and this could create an almost incredible number of new combinations between the 10 or 15 fatty acids and 20 amino acids. So just just imagine all the permutations and and so this compounds actually exist as as the group of other brands show as also recently investigated and and so it's really we're talking now about a huge number of chemical mediators. So the endocannabinoid open their containers their analogues, which may or may have not different similar biochemical Pathways normally have different receptors dead. We we talking about the several other targets that undermined into the G have Beyond City 162. We're talking about other enzymes. So we're talking about something something about more than a 250 chemical mediators more than fifty enzymes and and receptors and some of these receptors were actually known previously like the wage channels or the or the P bars and and and the interesting thing is that you know, of course we when the end of conversation became so big Then the next question was okay. THC is the only out of 100 and more a plan cannot be known that interact with the endocannabinoid system. What about maybe maybe if you don't look only at the end of can access them, but we look at the expanded n. Can have this Summit this and maybe the other cannabinoids with interact with the endocannabinoid home, even though they don't in fact with the entertainment system. This is true to a large

Mechanism Of Action Physical Exercise Endocannabinoidome Endocannabinoid System ECS Cannabinoids THC Cannabis Vincenzo Di Marzo Endo Rafi Ennis NSA Tennis
Been Caught Stealing

Your Brain on Facts

04:40 min | 1 year ago

Been Caught Stealing

"Thankful faults jewelry and fine art. Maybe a casino carefully organized plans by people dressed in black turtlenecks with lots of cool gadgets close calls. What we remember as the daring heist of one of the world's most famous paintings. was really neither of those things. The heist wasn't particularly daring and the theft of Leonardo DAVINCI's Mona Lisa. Wasn't even noticed until well after it had happened. My Name's Moxy and this is your brain on facts. These days the Mona Lisa also called in Italy login Kanda and her famous enigmatic smile hang in a prominent place in the Louvre in Paris. It holds the Guinness World Record for the highest known insurance valuation in History at one, hundred, million dollars in nineteen, sixty two. So. That would be about eight hundred million dollars today. Over six million people go to see it each year. It's so popular that you can't even snap a quick Selfie of it without having a few dozen other strangers, hands, and cell phones in the frame. This popularity certainly wasn't the case when the painting was I hung in the Leuven eighteen o four or for the century subsequent. Neither was popular with critics when the artistic elite who often relegated it to the low end of DAVINCI's work it was basically just another painting. It was so unsocial in fact that it took the better part of twenty four hours before staff even noticed the painting was missing in Nineteen. Eleven. A handyman named Vincenzo Perrugia was working in the museum and he simply waited in a closet until after the museum had closed. Tuck to the painting under his smock walked on out. He was unwittingly aided by a plumber also working in the museum who unlocked a for Peruta when he found himself stuck inside. The police were called and they searched the museum. The only sign they found the Japan Kanda was frame laying on a staircase. Though police did find some twenty one other paintings in the museum. The curator's had previously reported missing. The. Search went citywide then national then international. Ships were searched before they left France or after arriving in their port of call. A reward of over half a million dollars in today's money was offered. The Mona Lisa's picture was printed in newspapers all over the world. It became a of Mona Lisa Mania. The theft of this single painting served a spawn multiple criminal enterprises. People on the wrong side of the law knew that those with more money than morals would want to buy. LEGITIM- Kanda. A pair of confidence men from Belgium hired a small army of forgers to make quality fakes, which they then sold to select around the globe. They made sure their buyers were unlikely to ever meet and rested soundly knowing that no one would let on that they had purchased the most famous stolen painting in the world. Though today, one of them would probably take a selfie with it. The huge reward and the number of fakes in circulation meant the police were inundated with leads. For two years they searched tirelessly. But Fruitlessly The sixty man strong force even interviewed, Peruta Twice. But decided, he couldn't be the criminal mastermind they were looking for. Not only did those two years not yield the Mona Lisa the police didn't even find the forgeries. The head of the Paris police retired in shame. Did, peruse, you get an enormous payday for the stolen painting. People were soon to learn that he didn't steal it for money. When ferruccio approached museum in Florence to sell them the painting, the museum's director called the police instead. After. His arrest Russia's stated. I worked in the Louvre making frames for paintings stolen from Italy by France every day I pass login Kanda and swore I would return it to its rightful home. He seemed convinced he would be heralded as a hero. This was sadly not the case but the Italian courts were sympathetic giving him only a year in prison for the world famous theft. These days legit Kanda sits behind more bulletproof

Mona Lisa Kanda Theft Mona Lisa Mania Leonardo Davinci Legitim- Kanda Louvre Paris France Italy Vincenzo Perrugia Peruta Russia Japan Belgium Florence Ferruccio Director
"vincenzo" Discussed on People Helping People

People Helping People

07:51 min | 1 year ago

"vincenzo" Discussed on People Helping People

"To around a lot of the Kobe tracking and forecasting where we actually have you know developers that are working on things like that like helping forecast for four. The hospitals Which is very cool. And we'd even got some some folks working on communication methods for frontline workers to communicate with each other directly so they can help fight on the front lines and know what's coming and understand the disease better and understand the you know the treatments better. There being worked odd but of course there's more than just a couple of people trying to put something together. It's you know you need to make sure you're getting the right. The right information and make sure that you're you're kind of thinking about a lot of things there. Yeah and then Columbus Columbus as active. We mentioned it but they are up and running and so It's it's very similar to support Columbus e style. Where you can register your business you can also subscribe to the newsletter that allows you to To See all the ways that you can stay active and they'll send updates when they on updates come out not finished but also like mental health Got Kinda Register yourself on their There's like there's music coaches on here. Folks that WANNA still learn how to play music or vocal lessons there are There's like a martial artist on there so still offering virtual training and allowing people to see like what different aspects are on their this also just recently launched so The air table will likely grow as we keep pushing it out. I love it. There is yeah fantastic. I know there's so many GonNa talk it but unless you're unless you're actually on the site looking it's kind of like I'm just I'm just saying words so really thought Columbus Dot Com. You'll find all the resources and dot com dot ran on the you know rent on the front page. You'll be able to see everything pretty much. You can see the some of the resources that are relaunched. You can click on. You know to find more resources. You can sign up to our newsletter if you you know you just want to stay in the know what's going on and what's happening. You can donate if you're if you want to donate because You know we're trying to help. Some of the the food banks and things like that that are that are in need right now But it has everything there. If you want to help each one of volunteer she just have a question. You can email us We have some of our some of our media on there as well have we have. We do have a blog coming out soon as well. So that'll keep you know. Keep you up to date on pretty much. Everything is happening as we as we as it happened. And that just at a rate like this. Is You know something. That is totally run by volunteers. People who are jumping in ten. So what do you do during the day? What's your actual day job the? So I own a creative studio here in town. We do audio and video production Ironically a lot of our clients are outside of Columbus and unfortunately Because of this situation we lost a ton of our work that happened. That was happening during the three months. These three months kind of our our clients identified as like the peak event months. We doing a lot of event video coverage and so a lot of that kind of went downhill and actually totally cancel. I can't even. I can't even make that sound that. He goes to cancel some of the events. Were put on. Hold what I mean. Just just a few Yeah put on hold and so I was able to just identify opportunity to to help out here. But that's the day the day jobs. I'm using some still using some of those resources and my team I've kept my team employed and they're helping out with some of the can't stop stuff as well on when they can when we can still have some client work. So that's that's been good but being able to leverage that what I need to has been good to. That's fantastic. So what do people find? Your media. Company They can look after. Mark Dot Com but I right now. The main focuses can't stop COLOMBO TO CANCEL COLUMBUS DOT COM. And make sure that you are helping out where you can You can communicate me if you WANNA chat with me on twitter all the time then. Selena has the best place finery antastic. Yeah and we'll put all those resources in the shots as well appreciate them but that's fantastic This is just really exciting. I just love how much momentum it's gotten in it's been fun kind of diving into the story just about how people have come together and organized a new way and actually put thought into projects and generated on them to get a really decent product out there to help people in this time Yeah it's been fun to watch come together. It's been fun to work with folks. I never knew before. It's been fun to work with folks who I knew from just knowing their names in the community and then now actually working side by side. Um and it's been fun and enjoyable. It's been satisfying selfishly. Disappointing Helping other people really. That's what this is all about. So I WANNA make sure that you know. I'm doing my part and that's what I can do and I know that there's others affiliate exact same way. They just want to do their part. Whatever they can do and coming together for the greater good coming together as a team is really important But you know if you are someone who is kind of like you know now that they're you're at home and you miss that office environment. Maybe you miss that Camaraderie with with people and you want to help community you know coming to join us over. It can't Stop Columbus. We would love to have you and You know we'll definitely build that camaraderie right away. We've we've got tons of video calls or always doing we're doing virtual happy hours all the time and just trying to create some sort of normalcy through this whole thing has been has been on. It's been therapeutic for me. You know if I'm if I'm saying if I'm being candid about it. It's been very therapeutic for me. I know there's others feel the exact same way. They're super happy to have people to talk to you. Daily Happy People to come together with and have a drink you although virtually so that's been really really cool. Well thank you so much for sharing this story and going through everything that's going on. I hope I you know a lot. More people get involved and help a lot of people benefit from all these projects so thanks thanks for having me. Wow I just love this story. People coming together from all parts of the community to help create solutions to combat Kobe. Nineteen Literally People from the nonprofit sector corporate sector from Graphic Design Media University I just love seeing that if you've worked on any of these can't stop Columbus projects a big thank you. I love the work that you're doing and I love how much this is. Impacting our community and a huge. Thank you to Vincenzo for sharing his story but also the story of can't Stop Columbus and how people can come together to actually self organize and create things Which they would not be possible to their own. I think that's a real testament to the community that we have here in Columbus and I'm really excited to be part of that. You can find out all the resources for these on people helping people thought world and if you curious about his media company after mark. That's mark with a q dot Com after M. A. R. Q. Dot Com to curious more social impact. News you can sign up for our newsletter at social good blueprint dots up stack dot com and thank you so much for listening and Co checkout can't stop Columbus until Stein fears..

Columbus Columbus Columbus Kobe twitter Selena COLOMBO Graphic Design Media Universit Vincenzo M. A. R. Stein
"vincenzo" Discussed on People Helping People

People Helping People

10:21 min | 1 year ago

"vincenzo" Discussed on People Helping People

"Of really brainstorming. Heavy on an idea coming up with something running with it getting some feedback doing that validation going back and brainstorming again and really using the small sprints to pull an idea forward And I've seen that at play in can't stop Columbus so that whole process of taking the these best practices that people know from industry actually bringing them into this group I think that's super powerful just in developing really good ideas and giving them up there. That's very cool Where do you see this kind of going over the next month or two? I don't know I am. I'm seeing this as we're GONNA continue to develop and keep developing ideas and developing solutions and resources for for problems that pop up but I think we're all kind of trying to hope that it goes way right and we kind of hope that the big problem overarching problem was way. I think what we are seeing is There's other problems that may it brings. It brings. It brings problems out that you didn't even realize where they're so like even the good times right So I could see this going towards solving challenges in the community Outside of just corona virus in the cove in nineteen Pandemic because we are really like the things that we are trying to solve are still going to be there right at the top which is unfortunate but next door is one of the products we are resources we launched in. It's helping your neighbors get groceries like your neighbors helping neighbors kind of thing and so like why. Why why should that go away? That doesn't go away. You should want to help your neighbors and I think that's a cool. That's a cool resource like you can sign up to be a neighbor to help other neighbors ray. It's just people being people people helping people ray so those opportunities and things that have come up and in that sense of togetherness I think going forward is is going to power this but also help people realize that you can be part of a bigger effort. You can be part of a bigger community effort It doesn't have to be just around this. I'd love for this to be an example of people realizing. Hey here's how we can actually get together and work on projects and get something up and running right right so so often with a startup weekend hath on you know you you come in and you pitch an idea and you work on it for a weekend and then it doesn't really go anywhere But you know this idea of like. Is there a way to actually come in? Find other people who are interested in working on something and have that succeed in our get the resources and the and the thinking and the kind of pieces in place that will actually lead you to success. And I don't know if that's just because people are at home and they're not going out and have this extra time and they want to do something help. Maybe if there's something here of like hey people just realizing yeah there is a lot I can do just with whatever time I have to make a difference in my community. Yeah I mean people have time now. But they're realizing that with having all this time right in sometimes limitations Bring out creativity or bring out The best in people and so. I think that's what we're seeing now. You've talked about support combat next much. Did you talk about some of the other projects that have launched? We mentioned Columbus as active We also mentioned Ohio's Radio but I think that was really important. Now I wanted I kinda WanNa jump into this one and and team behind it. That that built that out Had did a fantastic job of really getting and they're still doing a fantastic job that that's not an ending job Ohio is ready. Dot Org is basically a resource for all the news that is coming out around you know Columbus and and really Ohio that is pertinent to current virus. And so there's a map at the top of the site that shows you like. How many cases earn each county? How many deaths during the county? There's a chart with like weekly infection totals. I'm an end. There's a there's a news feed right down the Center Front Center. Is The news. Feed very very important because it is giving you the source of that feed and he coverage that you're seeing it from and so like all right today there's an article nationwide insurance to give Refund Auto Insurance customers. Well a lot of people may not realize that is out there and they may not know about that. So where do they find it and so this is really important for them to get it and to know that it's a reputable source not facebook? You know not your not your mother's You know roommate from college or something posting something that has probably a very political spin on. And you're you're you're not getting the right information. This is stuff from the source Apple CEO Tim Cook. Tim Cook is donating. One hundred thousand ninety five Masto. Ohio Governor wine announces the death of a Marion corrections officer mean. You're seeing all here. This is like official information. So it's one stop shop for it And I think is important because to me a time like this information you know where we live in a world where information. We've never had so much information but we also allowed bad information out there and so this is trying to provide you with a one stop shop for the right information Yeah so that was really important to me. Ohio's ready Let's see we've got I'm just trying to pull up the ones out there. So we have the right the right ones Columbus helper really information about food housing and transportation services so when you go to the site it. Kinda ask you what you can you know. What does I can help you with today. And so let's just clicked on healthcare services you would click on that And then it'll ask if you're looking at what types of things you're looking for and so let's just say dental care. You can click dental care intellectually. Bring up a map. It'll ask you for your location and it'll pop up Resources for you so like a free clinics or anything like that and it will pop it up on your screen. It'll give you locations and contact those services That one like I said that's her. I clicked on dental care but community clinics. The same thing will pop up. It'll geo locate your position in an old show you where there's potential or this clinics in your area and I'll do that for other things like housing utility assistance. Where do you go for that emergency food clothing furniture in disaster services? You Click on that. It'll it'll help you with you. Know if you click on emergency food It'll do geo locate. You know pop up all the locations where can you can get help there And if you have a question that's not not on there. What do you do you know? I don't know that's a great question question I would. I would have this from the team. What they're doing on that one. I was just trying to segue into a CPA. Yeah well okay so you have. There isn't ask C. bus which is kind of like a read it for for Columbus and so asking for folks that are asking for things like are there resources available for hunger kids to find free daily meals and there's a couple of blasters on their of folks that are again people helping people here. It's kind of peer to peer. But it's a very if you've anyone's ever used read it before you know someone posts or someone ask a question and other people answer and most of the Times now. You hope that people are providing you with good stuff situation like this. You know people are helping what else we have will face masks for us. We just launched this week too. And so that one just so happened to coincide with deceasing wearing a mask is going to help where everyone should wear mask It just so happened that we were already working on this and it turned into kind of our PSA campaign for you know. Now's the time to wear masks the communities to wear them but some you know there's a lot of people are asking for a major like I can't find a mask. So how do I make one or an? We're being told not to buy and ninety five masks not that you can even get a hold of them if you try but let the hospitals right. Let them get their get their own. But you know there's a lot of folks that are crafty. They know how to sew and they can make a nicer like a better. A better fitting mask and so we've got sources for them to find and be able to create their own mask that want to sell it but also there's ways for them to just fold their own masks so we have resources we've got official sources for information on the site and were still developing at our we want. We want to actually have templates for people to use So they can just quickly make their own or they can quickly so their own And only takes about ten minutes occur to make a mask and then where it and save lives. If you're going out to the grocery store you're going to do something I deal. You're not going out much if it's just for the grocery To make sure your mouth and face or covered is very important and so we wanted to make sure people had the right information for how to Out To do that. Slashes launched this week very big deal And then we're you know we're working with you. Know I o means jobs and were helping them source Their job listings. We are working with You know the city Columbus on Cova nineteen resources making sure that people know to stay at home. Make sure they have all the health resources. So we're we're kind of linked up with with them in certain aspects there A couple projects I think are still kind of in the works.

Columbus Ohio official Tim Cook facebook Center Front Center Apple Refund Auto Insurance officer CEO Cova
"vincenzo" Discussed on Kingpins

Kingpins

12:24 min | 1 year ago

"vincenzo" Discussed on Kingpins

"Those muscles to work hinky dink and Bath House. John were looking to make a change. The man they had been employing to collect protection money from the first words body houses gambling joints and saloons was doing all right but they thought big. Jim could help them bring in even more money. They had recently raised the price of their weekly protection. Fees for illegal business dealings and some of the locals were less than pleased about it. No one was more outspoken about their objections than Georgie Spencer. The Madam a South Dearborn Street brothel will known around the first ward physically imposing an ill-tempered rumor had it that when the police had recently raided. Georgia's brothel. It had taken six uniformed officers just to get her into the police cab. Jim knew what he was getting into when he arrived he had heard enough about Georgie. To know she wouldn't hand over the money easily. Georgie barely blinked. At Jim's arrival. She knew the politicians might send some thug to convince her to pay up though she hadn't seen this doug in particular before she offered no hesitation in her answer. You can tell your bosses. I'm not paying no more protection. Jim Tried to hide his displeasure. This wasn't the first time you've been so openly challenged by a woman. His wife Victoria could be ferocious herself. But this was different. He had formed a path to prosperity by aligning with the two politicians. He couldn't return to them. Empty handed the brass knuckles. Were supposed to be a backup plan. Only to be used if things really got out of control but as he slipped them onto his hand and raised his fist. Jim Realized that part of him had wanted this from the moment. He was hired. Jim Koch Georgie across the jaw knocking her flat onto her back as she lay at his feet moaning in agony. Jim Carefully stepped over her to snatch her purse. He removed three hundred dollars. She owed and walked out the door. Big Jim walked out of Giorgis. Brothel with something far more valuable than the three hundred dollars. He now had Bath House. John and Hinky Dink's complete and total confidence and with it. He had his ticket to becoming the Crime. Lord of the first ward when we return. We'll follow gyms meteoric rise within the first words criminal world now back to the story as the spring of nineteen o nine drew to a close. Jim Colosimo couldn't help but to consider himself a very lucky man. He had taken well to his new role as protection collector. Each month he collected three hundred dollars from each of the districts brothels from the gambling joints. He drew up to twenty five dollars a day and from the saloons. He drew fifty dollars each week altogether. That would be the equivalent of over thirteen hundred dollars a week in today's dollars. Then money was then divided between Jim. Bath House John. Hinky Dink Kenna and the district. Police Captain Jim put his share toward his ever expanding business interests just months earlier former first ward business partners Roy Jones and George little had split up after a serious disagreement over profits. Their Empire hit included saloons gambling joints and brothels all across the first ward with the disillusion of this partnership there came void. The Gym was happy to fill bath house. John and Hanky Dink had already given him the authority to determine who did and didn't receive saloon licenses in the first ward so when Jones and little started selling off their businesses. Jim Let it be known on the streets that any potential buyer just might have some difficulty securing the appropriate permits this gambit worked to perfection. The bids started drying up and Jim purchased the remainder of Jones's little businesses at a hefty discount. He renovated a number of billiards halls. Gambling houses brothels and saloons all over the district by the end of the spring of nineteen o nine. You could hardly walk down any street in the first ward without passing at least one of Jim's businesses. Jim had amassed an empire in part because he was what's so many king and queen pins after him would aspire to be not just feared and respected figure in the underworld but also a gifted politician pulling the strings as well as any career statesman in July of that same year Jim Victoria finally moved out of their tiny apartment in the first ward for a ten thousand dollar mortgage roughly the equivalent of two hundred and sixty five thousand dollars today. The couple purchased a house just two miles south of the first ward but by the end of nineteen o nine. Jim Found himself tangled up in a major problem. The letters were simple. They first arrived in late. Nineteen O nine containing only a small phrase written in Italian. Mono Neera the black hand. Jim knew full. Well what they were capable of the black hand preyed on Italian business owners. They demanded payoffs in those who refuse to pay. Were dealt with swiftly and indiscriminate violence. Beatings.

Captain Jim Jim Victoria Jim Koch Georgie Jim Colosimo Bath House John Georgie Spencer Hinky Dink Dink Kenna Roy Jones Georgia doug Giorgis Hanky Dink George
Kingpins Rewind: Diamond Jim Pt. 1: Vincenzo Colosimo

Kingpins

08:44 min | 1 year ago

Kingpins Rewind: Diamond Jim Pt. 1: Vincenzo Colosimo

"Jim knew the stakes from the moment. Bath House. John Inky Dank had called. They had put their faith in him giving him an opportunity to be more than just a two bit pimp and now he had to show them that they hadn't made a mistake. He thought the local politicians had liked him because he was tactful and quick thinking the kind of guy who could make sure his people voted the right way but now jim saw things for what they were more than anything the Alderman's respected him for this his willingness to get his hands dirty to do what needed to be done. That was what made big Jim Different. Jim had been trusted to collect protection vs from the city's illegal brothels the price of protection had gone up and some people weren't happy about it. Particularly Georgie the meanest Madam in town. Jim didn't feel guilty about beating her. Perhaps the brass knuckles were a bit much but he had to send a message to every barmaid and madame around big Jim Cosimo had arrived and he had no intention of leaving. I'm how hard it and I'm kate. Leonard and this is King Pins on the PODCAST network every week. We journey inside the ranks of Organized Crime Rings From Street gangs to mafiosos to understand how a kingpin or Queen Pin Rises to the top of the underworld and why they fall as we follow the lives of infamous crime bosses will explore how money and power change them and how it changed the community around them. This is our first episode on Jim. Cosimo one of America's first modern kingpins. This week we'll be exploring his rise from indigent immigrant to crime. Lord of Chicago's Red Light District. Next week we'll look at his fall from grace arrest and the lasting legacy of his empire. You can listen to. All of Park has shows wherever you listen to podcasts. And if you enjoy the show one of the best ways to help us to leave a five star review now let's dive into the life of Chicago's first notorious Vice Lord. Big Jim Cosimo. Jim COSIMO was a self made man. He had come from nothing and yet had risen to become. Chicago's most feared and respected crime. Lord everybody knew Damon Jim and not just for his jewelry and that flashy three piece suit. He always wore for every moment. Jim had spent as a beggar peddling newspapers on the street corner. He intended to more than make up for it now that he had money in his pocket. Jen Colosio wasn't a pimp. He may have begun his criminal career selling sex on the Chicago streets but he had worked long and hard to become something much more than that by nineteen fourteen. Jim just turned thirty six. He already controlled be directly or indirectly more than one hundred businesses in. Chicago's first ward the Red Light district. He owned gambling joints and opium parlors billiards halls and saloons. Some even whispered that he sold Italian national lottery tickets and ran an underground wine business. Jim was in the business of sin and business was booming estimates at the time had him clearing well over half a million a year which in today's dollars would equate to roughly twelve and a half million. Jim Rarely traveled anywhere. If not by uniform chauffeur his elegant jewelry it led many to start calling him. Diamond Jim a name. He more than willingly accepted. He had a reputation now and it was one. He looked forward to living up. Two years. Spent living in luxury. Had led jim to develop an affinity for the fine arts. One art in particular stood out as his favourite the opera. He came to every show sometimes buying up as many as thirty seats. He always brought an entourage. Sometimes it was just a few of his men and their wives other nights. It was the men and their girlfriends after every show. Jim was welcomed backstage. Every member of the Chicago. Opera Company recognized him. He invited the singers. And the Maestro over to his restaurant call a simos cafe. He knew they would come. They always did after the show. Jim Returned to the restaurant and poured himself a drink since its opening in nineteen. Ten COSIMO's cafe had quickly become one of Chicago's hottest nightspots politicians celebrities and wise guys alike all gathered there each night to enjoy the old school Italian cooking and lively entertainment but it was the after dinner activities that truly endeared cosimo's cafe to the Chicago elites gambling joints were dime a dozen but where else but coliseum ohs could an intrepid diner go upstairs and gamble until the wee hours of the morning with hardened criminals state senators and foreign actresses alike. One night at cosimo's cafe sometimes bag jim more than a week's worth of his brothels receipts and Jim knew he was really selling the same thing at either venue not just food or sex. He was selling something far. More important. An experience Jim saw little distinction between the customers at his brothels. And those who pulled cigars and gambled away thousands at his restaurant as far as he was concerned. The only real difference between the two was that you never had to pretend you cared whether the brothel patrons had enjoyed themselves and for Jim pretending to care was the worst part he had lived his life without conscience never stopping to consider who he was hurting along his way. This way of living had done him. Well it had been the factor that allowed him to grow from nothing into the Titan. He had become the story of Jim. Cosimo begins in colostomy a small mountainous town in southern Italy with the birth of a child. By the name of Vincenzo. By the time Vincenzo Cosimo was born on February sixteenth. Eighteen seventy eight. The economy in southern Italy had taken a turn for the worse with jobs. Few and far between men of working age. Were already starting to ship off to the United States in hopes of finding their fortune but leaving colostomy was hardly an option for Vincenzo. Father Luigi who had grown up in the tiny mountain town Luigi Zone father remained. The area's most wealthy landowner. He would raise his family here. No matter how difficult it may be. Unfortunately those plans were dashed by the tragic passing of Luigi Wife Vincenzo. Mother JUST SUBPOENA. Luigi was now a widower with four children to take care of and with his own job prospects dim at best amid the stalling economy. He made a decision that would change the course of history in eighteen. Ninety one Luigi send his youngest son Vincenzo off to America. He was only twelve years old with a bright future ahead of him. Luigi hoped the boy would become wealthy enough to support the rest of the colosseum. Oh clan three long weeks after departing from Naples Vincenzo and his twenty one year old half brother. Antonio arrived by steamship into New York Harbor. The pair hardly had any time to enjoy the New York skyline before they were put on a train to Chicago where Luigi had made arrangements to have the boys room in the city's ever-growing Italian neighborhood Antonio was ready to go home before the pair had even arrived he'd been tasked with leading the youngster across the Atlantic but he had no interest in staying in America as soon as he ensured that Vincenzo had a roof over his head Antonio bid his younger brother. Good bye and luck.

Damon Jim Jim Cosimo Chicago Vincenzo Cosimo Jim Different Luigi Red Light District Naples Vincenzo America John Inky Dank Italy Bath House Georgie Alderman Simos Cafe Jen Colosio Opium Leonard Antonio New York
Bond Girl Style, an inteview with Dr. Monica German

Dressed: The History of Fashion

04:14 min | 2 years ago

Bond Girl Style, an inteview with Dr. Monica German

"Other balloons certainly wear traditional traditional western clothes. But they're also subverting. The way in which they are wearing. Those Western close bond is always impeccably dressed. The suits of the other villains from Goldfinger to Hugo drax are produced almost a grotesque effects took the bodies of the villains they move screw task aradio Britishness of course in the book as well as into film Goldfinger angle fingers. Here's an henchman odd job. Who Wears a traditional Western suits at down to bowler hat but the effectively looks like okay grotesque parody of Englishness the for reinforcing that idea of racial difference which is at all Switzer British wideness and this power dynamics play out a little bit differently in the interactions between double o seven and the ladies that cross his path in these inevitable travels? And you know as you've already touched on at the time of Fleming's initial manuscript that patriarchal mindset worn out of colonialism was still very much in place. So how did this inform the way that Fleming wrote about women and in particular the women that bond encounters brought what. This isn't a very very intriguing question. Because one of the things about Bundy's that he never seems to score we British ladies especially British winds latest. So he's loggers are always foreign or women of color so there seems to be a suggestion whereby they British woman remains untouchable and untouched. She still represents the unconquered unconquered all the old Britannia the P. to me of DC. Of course the unconsummated relationship between bond and moneypenny accursed earth. Floor extremely hard with all especially the earlier movies when she's played by Lois Maxwell but nothing ever happens. It's a safe. The reason unwritten rule in fact in the novels Fleming always goes as far as saying is there is an an unwritten rule that that relationship can never be consumated. Those women can not be touched. They are part of the civil of the of the secret service US and the they were present in a way the British empire the whiteness. So the woman of the female body cannot be conquered by boomed or anybody else of course. We have a version of acts in addition to know where Mary true blood. Am A sex trade trade working for the secret. Service in Jamaica is killed and probably sexually violated by would flaming holes H. Hi Grow It. Mixed Chinese unblocked man dot sexual assault or the assault that has a sexual connotation eight self represents a subversion of the colonial authority and ideology the bond represents by first I when bond is overseas is always able to conquer the bodies all female foreign women sometimes they are white women sometimes. They're women of color but dot kind of relationship exists. Nevertheless it's a relationship that some would say say can never lead to marriage and the only time that bond ever goes near marriage of course with tragedy Vincenzo was also also not British but is wide but those relationships never go anywhere. Because the marriage signifies somehow bones mingling angling his is blocked with foreignness and bombed cannot do money also cannot settle down because he would not be. That's

Fleming Bundy Goldfinger Lois Maxwell Vincenzo Assault United States Foreignness Jamaica Hugo Drax DC Mary
"vincenzo" Discussed on WJR 760

WJR 760

02:05 min | 2 years ago

"vincenzo" Discussed on WJR 760

"To your? His name is Vincenzo. Is he related to the wizards? He is I believe it, brother. Will he come forward and be swans? This man does not understand English. Yeah. I bet we could work out very good by tomorrow. We'll be back with a song from Kevin on the other side of the Senate, sixty w. Seven sixty WJR News, Marie Osborne. President Trump's former personal attorney apologizing for his actions on behalf of the Trump organization and bringing evidence to Capitol Hill today to shore are his claims Michael Cohen tells the house oversight committee, he lied to congress. He took part in various financial dealings, and he made hush money payments, all on behalf of Donald Trump. But when accused by a Republican of appearing before the committee in hopes of reducing his prison sentence. I'm not really sure how my appearance here today is providing substantial information that the southern district can use for the creation of a case, chairman Elijah Cummings said Cohen had everything to lose and nothing to gain by appearing before the committee say he doesn't have anything to lose. Because they have a lot lose. If you is Colin begins a three year prison term in may, Linda Kenyon, Capitol Hill. The house has approved a measure requiring federal background checks for all firearm. Sales in France Burs, congressional passage of the first major come legislation in nearly twenty five years greeted by applause from the Democrats and the chamber who now control the house Detroit police chief James Craig has fired a Detroit police officer accused of making a racially insensitive remark on Snapchat in a post the social media post was made January thirtieth. Gary Steele makes condescending remarks about an African American woman. Police chief James Craig says he came to the decision to fire steel after a long investigation vast majority.

Vincenzo house oversight committee Michael Cohen President Trump Trump Detroit James Craig Marie Osborne Gary Steele wizards France Burs Elijah Cummings Kevin Senate Linda Kenyon congress chairman
Puerto Rican evacuees caught between eviction threat and devastation

John Williams

01:47 min | 3 years ago

Puerto Rican evacuees caught between eviction threat and devastation

"Teens family says they've been told he has a rib fracture his mom says she hasn't seen him yet because he's in police custody gunmen have killed the mayor of a town in western mexico where three italian men went missing in late january the prosecutor's office in you'll state says the mayor of take a leap was gunned down by assailants wielding rifles attack elite lineman's municipal worker was hurt in the attack on monday the missing italians are rafael russo his twenty five year old son antonio russo and his twenty nine year old nephew vincenzo seeming now all from the naples area several municipal police officers were arrested in february in connection with their disappearance authorities say the agents apparently handed the men over to a criminal gang and they have not been heard from since more than sixty mayors or maters elect have been killed in mexico since two thousand six often by criminal gangs hundreds of puerto rican families evacuated after hurricane maria are living in hotels across the us and they can stay there for at least three more weeks judge timothy helmet of massachusetts federal court granted the extension today he says a restraining order temporarily blocking their evictions from the hotels will remain in effect until at least midnight july twenty third allowing them to stay until checkout time the following day the vouchers for evacuees displaced by hurricane maria last september were initially supposed to expire last sunday there were about seventeen hundred families living in hotels as of saturday but that number was about nine fifty as of today fema says it will comply with the order and notify hotels the programs extended but said it has no further comment and wisconsin state department of revenue size received nearly five hundred sixty thousand claims for governor scott walker's one hundred dollar per child tax credit the deadline for filing a claim was eleven fifty nine last night do are spokeswoman patricia mayors didn't immediately replies you an email today asking how much the state has paid out democrats have accused walker of setting up the rebate and a five day.

Fema Puerto Rican Naples Antonio Russo Rafael Russo Patricia Mayors Scott Walker Wisconsin Rib Fracture Massachusetts Timothy Helmet United States Hurricane Maria Vincenzo Prosecutor Mexico One Hundred Dollar Twenty Five Year Twenty Nine Year
"vincenzo" Discussed on The Lowe Post

The Lowe Post

01:44 min | 3 years ago

"vincenzo" Discussed on The Lowe Post

"Guys who are secondary ball handlers like dante vincenzo is the grayson allen's you know the joshua cogos those guys who can play alongside star who can who can make shot who can you know make good decisions where the ball who can who can guard and that's where you know you're going to see this run from twenty to forty i can see like fifteen guys in that mode being drafted they're whereas in the past it used to be just big men there there are no big men in this draft outside of the top fifteen or five in the top fifteen and after that it's like the next one mike go forty five so i think this is going to be that'll be an interesting theme to track is just like how many guys over six nine get drafted you know from after robert williams next year's draft looking for in that same vein eight look there's very few big men right now maybe maybe maybe what kevin's piece is really about is it is really about a top five pick maybe the rest of these these maybe we are these guys are good that's that's the one thing my arguments like jerry jackson is good wendell carter is good mogambo is good marvin bagley is good the andre is good robert william i mean these guys are legit dudes i'd understand last year like i dunno caleb swan again you know like i didn't get that you know come to me like you can find that dude in free agency maybe for the minimum so why are you gonna use a first round pick on him not to pick on on portland but there were a lot of guys draft in the twenties last year we were like i just wanna just take a flyer on sterling brown or some some wing you know you have the warriors taking grayson allen right now i'm not sure the world is ready for that i'm ready i know.

dante vincenzo grayson allen mike robert williams kevin jerry jackson wendell carter marvin bagley robert william caleb swan portland
"vincenzo" Discussed on Little Stories for Tiny People

Little Stories for Tiny People

02:16 min | 5 years ago

"vincenzo" Discussed on Little Stories for Tiny People

"Totally milo replied so harry filling right now right now i am feeling glad that i know understand the sense asians that have sought dover me and grateful to you for explaining them to me milo smiled yet i also feel something else vincenzo said i spent last night in your shrubbery which by the way should be trimmed as it is quite hazardous that aside it was very different from my charging station at home and this morning i was not able to see the sunrise for my usual spot near the window at this time of day i am typically engaged in a useful project of some kind i thought i would be well suited for life among people but this feeling i am experiencing is making me think i was incorrect pinch chen so your home sick i love my home it does not make me sick no no homesick is when you're away from home for too long and you missed it a new monocle back is that is exactly what i am feeling i now wish to return home vincenzo straightened himself and headed for the door without looking back at milo upstairs grandma stretched and got out of bed to go search for milo as she walked down the stairs she saw flash of silver how laws that she muttered and crept down for a closer look just then milo pass by on his way to the door hey he called out grandma hidden the stairway and peered around the corner she saw small robot inches from the front door than chance oh term to look at milo i was just departing he said i know i mean milo stuttered i'm glad you're going home i know you want to but you're leaving without even singapopre a puzzle book fell over vincenzo is metallic features i am not in the habit of saying goodbye to anyone.

milo chen vincenzo
"vincenzo" Discussed on Little Stories for Tiny People

Little Stories for Tiny People

02:12 min | 5 years ago

"vincenzo" Discussed on Little Stories for Tiny People

"Hey except for rao heights he exclaimed with a giggle grandma laughed i guess you're right that is true everyone is feelings except for robots grandma i'm sorry for hurting your feelings thou wasn't nice thing to say thank you milo buried i'm really hungry grimace said taking a bite me to milo said this is so yummy grandma compliments to the of gramma smiled when they both dug into their meals little did milo now but across town a small robot named vincenzo was looking up the night sky okay so his real name was vr seven eight nine to dash nine nine b two seven but i'm going to call him thin chance to preserve moran sanity vincentians owes part of a robot colony mean by scientists a few years back he lived with several other robots and a house and the scientists monitored them and watch as they went about their days it wasn't a bad life but there was something different about finch and so than all the other robots finch hanzo had feelings the feelings feelings just like milo in his grandma and everyone else vincenzo wasn't meant to have feelings the scientists who designed him made a bit of a mistake in his programming that resulted in his feelings some enchants o'hadhmaill ever had any when explain his feelings to him all he knew was sometimes he didn't feel like getting up from his charging station in the morning and sometimes he got a weird tight feeling in essential cavity and sometimes he felt like microchips were going to spill out from his highs.

grandma gramma vincenzo finch milo grimace moran