12 Burst results for "Vincent Lynch"

"vincent lynch" Discussed on No Agenda

No Agenda

11:57 min | 1 year ago

"vincent lynch" Discussed on No Agenda

"Carell. We're almost there. We are almost elevating our birthday. That'll be on the twenty six so on Sunday we will celebrate largely on the birthday counter for today. John Kendall says Happy Birthday beautiful awful wife Megan Kendall. She celebrated two to three days ago on the twenty-first and today Amanda Walk. Lynn says happy birthday to her husband. Jamie he is celebrating his birthday today on October. Twenty four th happy birthday from everybody here. The best podcast in the universe take change. Who Don't want to be such a great gym? No Sir Terry Knight Night of Crowley's Ridge as we heard earlier today officially become Sir Desk Stroh on his way to his Bernie and we thank him for his Continue you support of the no agenda. Show the best podcast in the universe. According to the report you can go ahead and look it up. Let's take a look at our See we think we have quick meet up list. Did you hear you know I'd forgotten about this. MEET UPS DOT COM started charging people we talked about it. They start charging mansion and. I said I couldn't confirm it Well the IT's confirmed and the reason they're doing that is they were purchased. Do you know who owns meet. UPS MEET UPS DOT COM MEET UP DOT COM. Nobody I'm about to be sickened. We work like hey man. GotTa you've got to keep the jet flying charge. meet up Tucker some money. That's business so we the These agenda meet UPS. That's right we don't charge. We've got a free place for you to go and find out about your meet ups or go and create one your Ronin snow agenda meet UPS DOT Com. And here's what's coming up today Nashville. Tennessee might've been this morning. After that was the early morning meeting where the one tonight To Morrow Ro Portland also Charlotte. North Carolina and New Cumberland Pennsylvania on the Twenty Sixth National Tennessee Colorado Springs and Shanghai October. Twenty Seventh Plymouth Michigan November first Seattle November Second Boston. There's the Tri State area which they hope will include Pennsylvania. I think they're part of it but maybe it's just New York New Jersey and Connecticut November Seventh Newport Beach California also Myrtle beach. It's the beach meet. UPS November Eighth Nelson British Columbia into nine th of November North Charleston. South Carolina Auburn California and Sarnia Ontario Sarnia Ontario November November twenty second indent in the Netherlands. That's where the government sits and on the twenty fourth in Utah. We have two separate meet UPS happening. This month is miniature in your world in den hops. It's Maduro Dumb It's it's not far from there. That's where it should be done. The shed the meet up Madero down. Madero Madero dumps to meet at miniature world. That's my Doodo dumb and now onto our nineties daming your big blade today because we've got some we've got four people here. I have three blades to choose from. I will pull out the extremely large. I felt it. Vincent Lynch Delgado Jillian Robbins and Scott. All of you. Please join us here on the podium for your official induction into the no agenda roundtable. The nights in the dame's thanks to your support in the amount of one thousand dollars or more. I am very proud to pronounce the Knights of Dominique Hook. Doc Day mambro's Sir fucking white male and Sir Scott of Fort liquor-dale for you. We've got hookers and blow rent boys in Chardonnay. Of course we've got Pineapple Dole whip and been yays Menes and Kale cookies and vodka brisket barrel aged copper mutton mean we got Ginger Ale gerbils sparkling cider escorts today. We'll throw it as a special hits Bourbon now. If you want to complete your entire ceremony you need to go to no agenda nation dot com slash rings so the four of you had over there now feeling information so eric. She'll can send that out to you. It's a use ending it only to us not posting it anywhere but also your ring. This is whatever digit you'd like to place which includes a toe ring. We're all good with that. And when you do receive with with your your signet ring with sealing wax and the certificate toot that out on NO AGENDA SOCIAL DOT com. Or if you must you can always put it on twitter so that small amount of people around the world can also enjoy but I think the real fun is it no agenda Agenda Social Dot Com. That's what I would recommend and thank you all once again for supporting the no agenda show. I Find Toe rings to be Kinda creepy me too but you know the the kids are doing these days about that But are the kids doing nowadays. That's a good question. Now ma'am were over time today but of course. Maybe I don't know what you're GONNA do do a couple more clips I I do some clips and then I just want to quickly funny. I got some funny clips. Okay this is the the EU parliament was meeting not in their normal place but in l. sauce or some place else and they were arguing about Brexit exit. What's the problem is they're arguing? But there's a guy get some squabbles or some squabbles and so then there's somebody had clipped down sun from the Sun Newspaper and so. This was a couple of weeks old though. Yeah but it's still the squabbles. Nice squabble is fun but it wasn't brand new. I'm glad you know wasn't brand new but it was a good squabble and I have have to clips I get this long squabble where they go back and for this very well structured and then Farraj going off on somebody which is optional through the long squabble Flores Johnson Johnson has lost his majority in parliament the European election results every opinion polls show a majority will remain once. Britain has an extension attention across party majority in the House of Commons will objects Johnson from office. We would ask you for as long extension as possible so that a new government will be able also hold a new referendum and the UK will find a solution. I just want to ask my colleagues in the United Kingdom talking about how she thinks that our prime minister can't can't be trusted. Her party stood on a manifesto in two thousand seventeen of respecting the referendum results without any recourse to the general public. They have changed that to revoking articles fifty and stopping brexit. Hypocrisy thank you I. I think it's a statement but perhaps there is a question there somewhere. Thank you thank you. I'm in response to that. I would like to say that when there is no clarity. A never waugh's ause about what type of leave was on the referendum when we have a clarity about that whichever type of leave is is to be put to a second referendum that people people should have a choice and in response to the revoke thing would be after a general election and therefore after a clear vote to remain and there is a second question from Ms Fox Fox except excuse me. I'm not asking you. If you accept unmasking. The Lady Eighty who answer the question so now that lady will accept you do have the floor for thirty seconds and as you know. I'm very strict on thirty seconds. If you're so confident in your politics why don't you let us have a general election. Why for lip dams refuse fuse and vote against all voters in the country? Going to the polls. You've said you let them do it. And so you've taken something off the table able you decided on their behalf anti-democratically you all night the Liberal Democrat Dick and you say your Shantha Parliament. I'm ashamed at your British Shabby Society Question Lamed when I now you answer answer that because I daresay you'll have a good. I'm very ashamed of some of the things that have been put out recently by leave dot. Edu on the point of our parliament. I think our parliament is well overdue for general election but to remove the UK from the crash out. fewing the course at that the election when the seems to be a majority in the UK for remain would be an appalling travesty of democracy so we must secure the extension before we have the election and and then bring it on and we will win far more and peas and always have to on the BREXIT party. Man They're so lucky they're not. This is not happening. In America now people would be outside the all parliaments in the EU too with their guns shut up you morons will. I just wanted the play that clip because it does bring to the fore pretty much every issue. That's all of all of them. You know we got. They want to general election but they don't. I WANNA do a general election. They want a crash out but they don't want to cry. And then this nonsense. That people voted to leave but but they never voted for the mechanism. We have to to have a vote about how we leave. Yeah that was nonsense. There was never the way I recall. It was leave or not leave just made and I. They actually didn't know about any of the details about fifty or having no they didn't have any deal. There was no. It was just get out crash out or crash out the way they like to put it now with propaganda we should just use another term like bailout eject popout new. WHO's out doing basically Ed? This is this exit Uis out. It's kind of disgusting. When I think of that in context of Boris Johnson? Will you WANNA play the garage. Garage clip is too short. Okay we dealing with people acting in good faith. Yes that means you Mr Barnier you looking for solutions. You're looking to put obstacles in our way you may have calmed a very weak and Gullible Mrs may into signing up into a new treaty from which was escape. But you'll well not calling us. We don't want your treaty in any form. Even with Mister Johnson's proposed amendments. The referendum was very very clear. We voted to leave the institutions of the European Union. And to be free. And you know we've had enough of being talked down to by. Oh you insulted by messes Tusk and indeed YMCA. We will never accept a German Johnson attempting to annex a part of our nation. We simply won't have it. The good news is your wretched. Treaty is off the table support for a clean break. Brexit is growing and it will be the winning tickets at the next general election so the troll rooms are helping popout chip in the P- you pull out ejects it. I liked that one. ooh ejects it. That's a good one I li- it likely I think this show title get right ejected. Well Jacks Exit. Oh I think that may be taking it too. Far Remind me. I have an exit strategy to.

"vincent lynch" Discussed on 600 WREC

600 WREC

11:27 min | 1 year ago

"vincent lynch" Discussed on 600 WREC

"Sought significantly better treatments. Doctors study cancer is vulnerability. So they can attack cancer when it happens. And they try to understand why cancer happens in the first place. So someday, they can prevent it. Normally cells will divide when they need to and then stopped growing in the case of cancer. What happens is the cells continue to divide over and over and over again. And they've lost the ability to stop growing. That's Dr Joshua Schiffman, professor of pediatrics at the university of Utah and an investigator at the Huntsman Cancer Institute there and eventually they become so large that they take over northern in the body. Sometimes they spread to different locations in the body. And if left untreated, they'll go onto almost certainly kill the patient over the course of a lifetime. About forty percent of people will develop cancer. But what many people don't realize is that the first steps toward cancer are happening in our bodies all the time, but they don't get far everyday just walking down the street. We are getting hundreds of thousands if not millions of mutations, but our body is designed to actually eliminate those. So that we don't go on to develop cancer. Although even so half of all men in a third of all women will develop cancer throughout their lifetime. And as we get older our ability to fix those mutations in the accumulation of those mutations that sneak by DNA repair system begins to grow, and if you live long enough there, unfortunately is a pretty good chance that you may develop cancer, those are dying in your body all the time. So your body needs to replace those dead cells. So, you know, every time a cell dies. It's replaced more or less with another healthy cell. And sometimes that process goes awry, and sell it's not. Quite cancer all the way, but it's pre-cancerous and your body's immune system, for example, might recognize that pre-cancerous sell as not being quite right, and sort of mountaineering response against it and kill it. Dr Vincent Lynch is assistant professor of human genetics and organism biology and anatomy at the university of Chicago. Sometimes that process doesn't happen in those cells escape, for example, that immune surveillance, and then they start to mutate in ways that makes it much harder for your body to recognize them as foreign and that allows them to escape the normal mechanisms that keep uncontrolled cell proliferation in check why the immune system fails to detect those mutations is the subject of a great deal of research as Shiffman says age may often have something to do with it. But obviously sometimes it doesn't why would children get cancer. Because this is really an interesting question. Right. Why would someone so young developed cancer at such an early age? They haven't lived long enough to accumulate all those mutations that happens in time in. Of the environmental exposure. So we believe that there's a strong genetic component that contributes to the risk of childhood cancer. And we're trying to understand exactly what that component. If she hasn't been says a few children have genetically weakened immune system, their DNA repair mechanisms are themselves mutated. So their rate of developing cancer is very high when cancer develops in any of us a similar failure has occurred. There are over twenty two thousand different genes that we have as humans in each gene has a very specific job. And if those genes get altered changed or mutated then the instructions that those genes code no longer can be read in that Jean can't performance job. And some of these genes their job really is only to protect us from cancer. And if you start losing those genes, then you've lost your protection for cancer. Lynch and Shiffman say one of the principal cancer protection g. Genes in the body is called p fifty three or p fifty three. It's so important that some people call it the guardian of the genome when a cell starts to go awry when a cell starts to have a mutation or turn into a pre-cancer. So that there's a spelling mistake and its DNA p fifty three shows up on the scene and helps to fix it. It's almost like a big spell checker. So basically, it's hanging out in your cell all the time doing nothing, and then if your cell experiences DNA damage, it does two things it starts to stop watch which gives the cell time to repair the damage so normally cells are dividing and it stops the cell from dividing until the damage is repaired. The thing is it's counting is not giving the cell an infinite amount of time to repair the damage if it takes too long to repair the damage it causes the Celtic kill itself, and sort of the biological rationale. There is if there's only a little bit of damage, your Celcom probably repair that without there being much of a side effect. But if there's a lot of damage chances are the cell is going to be able to repair all of that damage very faithful. And so it can repair some of the damage correctly. But some of the damage may escape that repair. And if that's the case it's better to just kill the cell. But when those cancer protection jeans or the tumor suppressor genes when they get mutated or they don't work properly anymore. Then there's nothing protecting us from developing cancer. The cells have lost their first line of defense. Some animals, however, have a first line of defense that seems to never fail for example, only about three percent of elephants ever, get cancer and Shiffman and Lynch say that flies in the face of what you'd expect of a large animal elephants are one hundred times the size of people that means they have a hundred times as many cells, which is actually if you think about it a hundred times as many chances for randomly developing those mutations not only that elephants live quite a long time. They live fifty sixty seventy years that many cells divide. Decade after decade after decade, just by chance alone. All elephants should actually be dropping dead of cancer. But they almost never do. There's no relation between body size and the incidents of developing cancer and on one level. The answer is really simple. These big things have just of all ways to reduce their cancer risk and on another level. The answer is really complicated. It's well. Okay. How are they doing that? How they're doing. That has been the subject of both Shiffman and Lynch's research examining the elephant genome. They're separate studies in the journal of the American Medical Association and the journal he life show that the answer is pretty clear instead of two copies of that Fifty-three Jean. We were talking about all humans have two copies one from their mother one from their father instead of two copies to protect them from cancer elephants had forty copies so twenty times as many copies as people that could create an elephants a. Theoretically, nearly failsafe cancer surveillance system. One way that an organism could increase its cancer resistance is just have lots of extra copies of p fifty three. So if one of them becomes mutated and nonfunctional, there's backup redundant copies. I can take over the role of the normal copy. Lynch found extra p fifty three genes in skin cells of both Asian and African elephants from the San Diego zoo Shiffman took a similar route seeking elephant blood cells. I found myself at the local Utah, HOGAN zoo whenever blood was being drawn again for other reasons, we were able to get some of it to our lab and studying and sure enough what we learned was that these extra copies of p fifty three indeed seem to be contributing to the ability of the elephants out to rapidly remove any type of pre cancer that was occurring. She hasn't been put the elephants cells into a lab dish, and expose them to radiation. And chemotherapy prompt. DNA damage to make them pre-cancerous. And he did the same thing with human cells to compare how they worked and what we found was that always the elephants sales were much more sensitive to the DNA damage. They were able to eliminate those cells with the cancer and much more quickly. And we were able to demonstrate that the way they were doing that was they were activating this P fifty three system of cell death. And so the elephants we were able to say had evolved a much more robust system for eliminating cells that have DNA damage can go on to form cancer. And this actually makes a lot of sense. If you think about it from the perspective of elephant, they're so large so many cells they can't afford to get cancer because they would go extinct that research is going one step further now with a goal of turning elephant p fifty three into something that can help people. We're trying. To figure out is there a way that we could actually somehow deliver this elephant p fifty three to actually give to our patients to maybe treat or perhaps even one day prevent cancer. And maybe in the future who knows make a medicine that could be given to people. She hasn't been steam has exposed seven different kinds of human cancer cells to elephant p fifty three with dramatic results. The cancer cells shrivel and explode killed by the elephant p fifty three similar to if you put human p fifty three into a cancer cell where able to actually use laboratory techniques to put the elephant p fifty three into it and observe the effects in some of these cancer cells, and we're able to show that some of these cancer cells in a dish are actually like you said exploding undergoing a Potosi they actually shrivel up and go into that debt psych. Title, and then just basically turned into a little small pieces that finally disappear. So it's really very early, but it's still very encouraging. But if extra p fifty three is so protective Lynch asks why are elephants about the only animals that have it. If this was such a great answer to solving the cancer problem. Why haven't all the other animals that we looked at? And we looked at maybe a hundred of them. Why don't they have extra copies of p fifty three? And the fact that they don't suggest that there might be some trade off that goes along with having extra copies of p fifty three other studies that engineered extra p fifty three into mice show that they age quickly. At least win the p fifty three is turned on all the time. They didn't get cancer. But they quickly got old in other ways that doesn't happen if my syringe neared, so they're p fifty three is active only in the presence of DNA damage, but genetically engineering everyone's immune system doesn't seem to be a likely. Strategy at least not in the short run. She has been says the more likely route will be to try to create a medicine using elephant DNA, can we actually figure out a way to take this elephant p fifty three and make medicine out of it to help our patients to help treat cancer that they have or maybe one day in the way future to even prevent cancer. Just like the elephants don't have cancer. We want to figure out a way. How can we make it? So that people don't have to get cancer. Again. She is hopeful, but he's also cautious. This is not a cure for cancer. He says.

cancer DNA damage Dr Vincent Lynch Huntsman Cancer Institute Shiffman Jean university of Utah Celcom Dr Joshua Schiffman San Diego zoo Shiffman professor of pediatrics Potosi university of Chicago investigator chemotherapy journal of the American Medica Utah assistant professor
"vincent lynch" Discussed on 600 WREC

600 WREC

11:13 min | 1 year ago

"vincent lynch" Discussed on 600 WREC

"The Potomac river boat company whose to the war Georgetown waterfront national harbor and Alexandria, enjoying breathtaking views of the city and zero traffic votes depart every twenty five minutes from early morning to late night get out of the car and onto the water with atomic riverboat company. Connecting all waterfronts running through December thirty first learn more at Potomac river boat, co dot com answer happens in the first place. So someday, they can prevent it. Normally cells will divide when they need to. And then stop growing in the case of cancer, though, what happens is the cells continue to divide over and over and over again. And they've lost the ability to stop growing. That's Dr Joshua Schiffman, professor of pediatrics at the university of Utah and an investigator at the Huntsman Cancer Institute there in eventually they become so large that they take over Norbert in the body. Sometimes they spread to different locations in the body. Eighty and if left untreated, they'll go onto almost certainly kill the patient over the course of a lifetime about forty percent of people will develop cancer. But what many people don't realize is that the first steps toward cancer are happening in our bodies all the time, but they don't get far everyday just walking down the street. We're getting hundreds of thousands if not millions of mutations, but our body is designed to actually eliminate those. So that we don't go on to develop cancer. Although even so half of all men in a third of all women will develop cancer throughout their lifetime. And as we get older our ability to fix those mutations in the accumulation of those mutations that sneak by DNA repair system begins to grow, and if you live long enough there, unfortunately is a pretty good chance that you may develop cancer, those are dying in your body all the time. So your body needs to replace those dead cells. So, you know, every time a cell dies. Replaced more or less with another healthy cell. And sometimes that process goes awry, and sell it's not quite cancer all the way, but it's pre-cancerous and your body's immune system, for example, might recognize that pre-cancerous cell as not being quite right and sort of Mount Zion response against it and kill it. Dr Vincent Lynch is assistant professor of human genetics and organism biology and anatomy at the university of Chicago. Sometimes that process doesn't happen in those cells escape, for example, that immune surveillance, and then they start to mutate in ways that makes it much harder for your body to recognize them as foreign and that allows them to escape the normal mechanisms that keep uncontrolled cell peration check, why the immune system fails to detect those mutations is the subject of a great deal of research as Shiffman says age may often have something to do with it. But obviously sometimes it doesn't why would children get cancer. Because this is really an interesting question. Right. Why would someone so young developed cancer? Such an early age. They haven't lived long enough to accumulate all those mutations that happens in time in all the environmental exposure. So we believe that there's a strong genetic component that contributes to the risk of childhood cancer. And we're trying to understand exactly what that component. If she has been says a few children have genetically weakened immune system, their DNA repair mechanisms are themselves mutated. So their rate of developing cancer is very high when cancer develops in any of us, a similar failure has occurred there over twenty two thousand different genes that we have as humans and each gene has very specific job. And. And if those genes get altered changed or This mutated clue didn't then come out the until instructions more recently. that those genes When code rare no longer behind can be read the scenes in that production Jean photos can't performance of job. the sergeant And some pepper of sessions these genes their were job released really is to only the public to protect us from cancer. in And these if photos. you start We losing discover those. Jeans. Then there you've is lost a cardboard your protection cutout for cancer. of a man Lynch holding and a Shiffman rifle, say one of the but principal this cancer image protection is obscured genes in the body by George is called Harrison p fifty three on or the t album p fifty cover, three and it's so so important we that some we people can only call see it the guardian in of the genome the when photos a cell starts that were released to recently, go awry and you can when just a cell look this up starts on the to internet. have a mutation or turned Now. into a This pre-cancer. figure has been So identified that there's a as spelling mistake Timothy and its DNA Carey who p is fifty three an American shows up on film the scene and and helps television, to fix it. actor It's almost like a big spell checker. it So was basically, taken it's hanging from out a in your nineteen cell all fifty the time six doing nothing, Stanley and Kubrick then if film your cell called the experiences killing DNA and damage, carries. it does two Character things it is starts holding to stop watch and aiming which gives a rifle. the cell time to repair the damage so normally cells are dividing and it stops the cell from dividing until the damage is repaired. The thing is it's counting is not giving the cell infinite amount of time to repair the damage if it takes too long to repair the damage, it causes the Celtic kill it self and sort of the biolog-. Article rationale there is if there's only a little bit of damage, your Celcom probably repair that without there being much of a side effect. But if there's a lot of damage Kansas are the cell isn't going to be able to repair all of that damage, very faithfully. So it can repair some of the damage correctly. But some of the damage may scape that repair. And if that's the case it's better to just kill the cell. But when those cancer protection jeans or the tumor suppressor genes when they get mutated or they don't work properly anymore. Then there's nothing protecting us from developing cancer. The cells have lost their first line of defense. Some animals, however, have a first line of defense that seems to never fail for example, only about three percent of elephants ever, get cancer and Shiffman and Lynch say that flies in the face of what you'd expect of a large animal elephants are one hundred times the size of people that means they have a hundred times as many cells, which is actually if you think about it a hundred times as many chances for randomly developing those mutations not only. That elephants live quite a long time. They live fifty sixty seventy years that many cells dividing decade after decade after decade, just by chance alone. All elephants should actually be dropping dead of cancer. But they almost never do. There's no relation between body size and the incidents of developing cancer and one level. The answer is really simple. These big things have just always to reduce their cancer risk on another level. The answer is really complicated. It's while. Okay. How are they doing that? How they're doing. That has been the subject of both Shiffman and Lynch's research examining the elephant genome. They're separate studies in the journal of the American Medical Association and the journal life show that the answer is pretty clear instead of two copies of that p fifty three gene we were talking about all humans have two copies one from their mother one from their father instead of two copies to protect them from cancer elephants had. Forty copies. So twenty times as many copies as people that could create an elephants a theoretically, nearly failsafe cancer surveillance system. One way that an organism could increase its cancer resistance is just have lots of extra copies of p fifty three. So if one of them becomes mutated and nonfunctional, there's backup redundant copies. I can take over the role of the normal copy. Lynch found extra p fifty three genes in skin cells of both Asian and African elephants from the San Diego zoo Shiffman took a similar route seeking elephant blood cells. I found myself at the local Utah, HOGAN zoo whenever blood was being drawn again for other reasons, we were able to get some of it to our lab and studying and sure enough what we learned was that these extra copies of p fifty three indeed seem to be contributing to the ability of the elephants out to rapidly remove any type of pre cancer that was occur. Shiffman put the elephants cells into a lab dish and exposed them to radiation and chemotherapy, prompting DNA damage to make them pre-cancerous. And he did the same thing with human cells to compare how they worked at what we found was that always the elephants were much more sensitive to the DNA damage. They were able to eliminate those cells with the cancer and much more quickly. And we were able to demonstrate that the way they were doing that was they were activating this p fifty three system of cell death. And so the elephants we were able to say had evolved a much more robust system for eliminating cells than have DNA damage and can go on to form cancer. And this actually makes a lot of sense. If you think about it from the perspective elephant, they're so large so many cells they can't afford to get cancer because they would go extinct that research is. One step further now with a goal of turning elephant p fifty three into something that can help people were trying to figure out is there a way that we could actually somehow deliver this elephant p fifty three to actually give to our patients to maybe treat or perhaps even one day prevent cancer. And maybe in the future who knows make a medicine that could be given to people. She hasn't been team has exposed seven different kinds of human cancer cells to elephant p fifty three with dramatic results. The cancer cells shrivel and explode killed by the elephant p fifty three similar to if you put human p fifty three into a cancer cell where able to actually use laboratory techniques to put the elephant p fifty three into it and observe the effects and some of these cancer cells, and we're able to show that some of these cancer cells in a dish are. Are actually like you said exploding undergoing as a crib a hostess from they the actually opening paragraph shrivel up of Andrew and go our into nets that death article cycle, in and paranoia then just magazine. basically turned Alastair into Crawley's little small penchant pieces for that photo finally bombing the world's disappear. greatest conspiracies So it's has been really discussed by very us in previous early, articles. but But it's in the still present case, very the analogy encouraging. can be But taken if quite extra literally p fifty three Crawley's is so protective mug is Lynch planted asks squarely why on are the elephants Beatles. Sergeant about the Pepper's only lonely animals hearts that club have band it. Elba, If this cover, is such a great arguably, answer the most to iconic image solving in pop culture the cancer problem. Why are haven't present all the focus other animals relates that to Crawley's we look back, involvement and we looked at in maybe the a Paul hundred of them. is dead Why conspiracy don't they have extra copies and of more p generally fifty three? And the the fact Beatles that they as don't a whole suggest the that Fab there might Four be some are the cornerstone trade-offs of that goes modern along day pop with having culture, extra which copies for some of fifty makes three them other inextricably studies linked that engineered with nefarious extra p workings fifty three into of mice the establishment show that the age quickly as we at shall find. least win Mr the p Crowley fifty three is has turned managed on all to the time. worm his way They didn't into the center get cancer. of this alleged But they quickly rotten got old apple, in other ways but as is that the case doesn't with happen all if things my conspiracy, syringe inured, vast so they're p go fifty flies three is between. active What only is real? in the presence. And Of DNA what is damage, indulgent fantasy but genetically of the tin engineering foil headed everyone's community immune system today? doesn't Fifty seem years to be after a likely the death strategy. hoax. Started At least not McCartney in the short run is back Shiffman on top of says the charts. the more likely His route newly released will be to album try to Egypt create station a medicine went straight using to number elephant one on DNA, the billboard two can hundred we actually and he's embarking figure out on a a worldwide way tour..

cancer Dr Vincent Lynch Shiffman Huntsman Cancer Institute DNA damage Potomac river university of Utah San Diego zoo Shiffman Dr Joshua Schiffman Elba Celcom Georgetown Beatles Alexandria Kansas professor of pediatrics university of Chicago Norbert investigator
"vincent lynch" Discussed on News Talk KOKC 1520

News Talk KOKC 1520

09:39 min | 1 year ago

"vincent lynch" Discussed on News Talk KOKC 1520

"Have sought significantly better treatments. Doctors study cancer is vulnerability. So they can attack cancer when it happens, and they try to understand why cancer happens in the first place. So someday, they can prevent it. Normally cells will divide when they need to and then stopped growing in the case of cancer. What happens is continued to divide over and over and over again, and they've lost the ability to stop growing that sucker Joshua Schiffman, professor of pediatrics at the university of Utah and an investigator at the Huntsman Cancer Institute there and eventually they become so large that they take over northern in the body. Sometimes they spread to different locations in the body. And if left untreated, they'll go onto almost certainly kill the patient over the course of a lifetime about forty percent of people will develop cancer. But what many people don't realize is that the first steps toward cancer are happening in our bodies all the time, but they don't get far everyday. Just. Walking down the street. We're getting hundreds of thousands if not millions of mutations, but our body is designed to actually eliminate those. So that we don't go on to develop cancer. Although even so half of all men in the third of all women will develop cancer throughout their lifetime. As we get older our ability to fix those mutations in the accumulation of those mutations that sneak by DNA repair system begins to grow, and if you live long enough, there is a pretty good chance that you may develop cancer, those are dying in your body all the time. So your body needs to replace those cells cell dies. It's replaced more or less with another healthy cell, and sometimes that process those and sell it's not quite cancer all the way, but it's pre-cancerous and your body's immune system, for example, might recognize that precancerous sell as not being quite right, and sort of mountaineering response against it and kill it. Dr Vincent Lynch is assistant professor of human genetics and organised mobile and anatomy at the university of Chicago. Sometimes that process doesn't happen in those cells escape, for example, that immune surveillance. And then they start to mutate in ways that makes it much harder for your body to recognize them as foreign and that allows him to escape the normal mechanisms that keep uncontrolled supplementation. Check why the immune system fails to detect those new -tations is the subject of a great deal of research as Shiffman says age may often have something to do with it. But obviously sometimes it doesn't why would children get cancer. Because this is really an interesting question. Right. Why would someone so young developed cancer at such an early age? They haven't lived long enough to accumulate all of those mutations that happened in time in of the environmental exposure. So we believe that there's a strong genetic component that contributes do the risk of childhood cancer. We're trying to understand exactly what that component. If she hasn't been says a few children have genetically weakened immune system, their DNA repair mechanisms are themselves mutated. So their rate of developing cancer is very high when cancer develops in any of us, a similar failure has occurred there over twenty two thousand different genes that we have as humans and each, gene. A very specific job. And if those genes get altered changed our mutated then instructions that those genes code no longer can be read in that, gene can't performance job. And some of these genes their job really is only to protect us from cancer. And if you start losing those genes, then you've lost your protection for cancer login Shiffman. Say one of the principal cancer protection genes in the body is called p fifty three or p fifty three it so important that some people call it the guardian of the genome when a cell starts to go awry when a cell starts to have a mutation or turn into a pre cancer. So that there's a spelling mistake in its DNA p fifty three shows up on the scene in helps to fix it. It's almost like a big spell checker. So basically, it's hanging out in your cell all the time. And then if your cell experiences DNA damage, it does two things it starts to stop watch. Which gives the cell time to repair the damage so normally cells are dividing and it stops the cell from dividing until the damage is repaired. The thing is it's counting is not giving this infinite amount of time to repair the damage if it takes too long to repair the damage, it causes the Celtics itself, and sort of the biological rationale. There is if there's only a little bit of damage, your can probably repair that without there being much side effects. But there's a lot of damage Kansas. Are this isn't going to be able to repair all of that debt very faithful of it can repair some of the damage correctly. But some of the damage may state that repair, and if that's the case it's better to just kill the cell. But when those cancer protection jeans or the tumor suppressor genes when they get mutated or they don't work properly anymore. Then there's nothing protecting us from developing cancer cells have lost their first line of defense. Some animals, however, have a first line of defense that seems to never fail for example, only about three percent of elephants ever, get cancer and Shiffman and Lynch say that flies in the face of what you'd expect of a large animal elephants are one hundred times the size of people that means they have one hundred times as many cells, which is actually if you think about it a hundred times as many chances for randomly developing those mutations not only that elephants live quite a long time. They live fifty sixty seventy years that many cells dividing decade after decade after decade, just by chance alone. All elephants should actually be dropping dead of cancer. But they almost never do. There's no relation. Between body size and the incidence of cancer and on one level. The answer is really simple, these big things and just evolved ways to reduce their risk on another level. The answer is really complicated. How are they doing that? How they're doing. That has been the subject of both Shiffman and Lynch's research examining the elephant, Gino, they're separate studies in the journal of the American Medical Association and the journal he life show that the answer is pretty clear instead of two p fifty three gene we were talking about all humans have two copies. One from their mother want from their father instead of two copies to protect them from cancer elephants had forty copies so twenty times as many copies as people that could create an elephants, theoretically, nearly failsafe cancer surveillance system one way that an organism could increase its Hanser resistance is lots of extra copies of. So if one of them becomes mutated and nonfunctional, there's backup redundant copies. I can take over the role of the normal. Lynch found extra fifty three genes in skin cells, both Asian and African elephants from the San Diego zoo. Shiffman. Shook a similar route seeking elephant blood cells. The local Utah HOGAN zoo whenever being drawn again for other reasons, we were able to get some of it to our lab and study it and sure enough what we learned was these extra copies of p fifty three indeed seemed to be contributing to the ability of the elephants out to rapidly remove any type of pre cancer that was occurring Shiffman. Put the elephants sales into a lab dish, and expose them to radiation and chemotherapy, prompting GNA damage to make them pre-cancerous. And he did the same thing with human cells to compare how they worked and what we found was that always the elephants sales were much more sensitive to DNA damage. They were able to eliminate those cells with the cancer in much more quickly. And we were able to demonstrate that the way they were doing that was they were activating this P fifty three system of south. And so the elephants we were able to say had evolved a much more robust system for eliminating. Cells that have DNA damage and can go on to form cancer. And this actually makes a lot of sense. If you think about it from the perspective elephant, they're so large, so many cells they can't afford to get cancer because they would go extinct that research is going one step further now with a goal of turning elephant p fifty three into something that can help people. We're trying to figure out is there a way that we could actually somehow deliver this elephant p fifty three to actually give to our patients to maybe treat or perhaps even one day prevent cancer. And maybe in the future who knows make a medicine that could be given to people. She hasn't been steam has exposed seven different kinds of human cancer cells to elephant Fifty-three with dramatic results. The cancer cells shrivel and explode killed by the elephant Fifty-three similar to if you put human p fifty three into a cancer cell where able to actually use laboratory techniques to put the elephant Fifty-three into it and observed the effects in some of. These cancer cells and were able to show that some of these cancer cells in a dish are actually like you said exploding undergoing eight to toast. They actually shrivel up and go into that death cycle, and then just basically turned into little small pieces that finally disappear. So it's really very early, but it's still very encouraging. But if extra p fifty three is so protective Lynch asks why are elephants about the only animals that have it. If this was such a great answer to solving the cancer problem. Why haven't all the other animals that we look back, and we looked at media? Why don't they have extra copies of p fifty three? And the fact that they don't suggest that there might be some trade off that goes along with having extra copies of p fifty three other studies that engineered extra fifty three into mice show that the age quickly at least win the p fifty three is turned on all the time. They didn't get cancer. But they quickly got old in other ways that doesn't happen if mice are engineered. So they're p fifty three is active only in the presence of DNA damage, but genetically engineering everyone's immune system doesn't seem to be. Likely strategy and least not in the short run Shiffman says the more likely route will be to try to create a medicine using elephant DNA, can we actually figure out a way to take this elephant fifty three and make medicine out of it to help our patients to help treat cancer that they have or maybe one day in the way future to even prevent cancer. Just like the elephants don't have cancer. We want to figure out a way. How can we make it? So that people don't have to get cancer. Again, Shiffman is hopeful, but he's also cautious. This is not a cure for cancer. He says except.

cancer Huntsman Cancer Institute Shiffman DNA damage Dr Vincent Lynch university of Utah Joshua Schiffman professor of pediatrics Kansas university of Chicago San Diego zoo investigator gene Celtics principal assistant professor journal of the American Medica
"vincent lynch" Discussed on The Science Hour

The Science Hour

04:05 min | 2 years ago

"vincent lynch" Discussed on The Science Hour

"Of those extra copies are capable of being turned on and making a functional protein because when they get it to go from having one copy of multiple copies, they all lost their sort of genetic on off switch, which turns the gene on, except elephants elephants revolved and aunts, which which switches the gene on when there's sort of cancer causing stress around. So we able to isolate the elephants specific genetic variations than you can fake in on the ones that are most likely to suppress Kansas. Fortunately, African elephants, Asian elephants Iraq's has manatees on a bunch of other mammals have had their Gino. To sequence. So we can just go into the genomes of these things and say, okay, what's unique to elephant lineage? Some of those things not all of them, but some of them will have to do with the evolution of enhanced cancer protection. The problem with that is that you just end up with a basically an excel sheet that in one column has gene name. Then the other column has how many copies of that gene each species has. And usually this is not very informative, but this gene, the lifting is pretty easy to know what it's doing because lifts stands for leukemia, inhibitory factor. So I would suggest that this is the factor that inhibits leukemia. So when we saw this, this lift gene pop up in our Jeanne list, we were like, oh, well, that's probably something that's bringing roll here. And what we found was if we prevent this extra copy of the gene from working elephants theirselves, don't die as efficiently as they normally do when you give them DNA damage. So we know that this gene is contributing to that increase sensitivity of elephants LCD damage because when we stop it, the cells lose that sensitivity to the debt. This is all about getting a better handle on the networks of cancer in Edison specifically, obvious next question. Can this informs at all about possible cancer therapies in humans? Yeah, right. So if we can understand how it is that some of these animals like elephants whales and bats evolved to be cancelled resistant at a genetic level at a molecular level and at a cellular level that will tell us something really profound about cancer as a process. And that can hopefully inform us about how to sort of transfer that knowledge into maybe developing new drug therapies, new targeted drug therapies, freaking, that's it's not very likely that we're going to sort of genetically engineered humans to have the l. an extra version of the elephant gene, right? But if we can figure out how that gene functions, maybe we can make a drug mix it and then use that drug to treat people with cancer. That's Vincent Lynch. Have another chat with vehicle Nabet of a subject change because the loss of my season, this chat presented this program. I was reporting on these huge heatwaves across much of the northern hemisphere. Now, all of these places. Have finally cooled down. It certainly has here in the UK so I'm getting a better night's sleep but much more importantly, it much more seriously than that. We are seeing some impacts on the ecosystem on animals fish and so on. So Vic, gonna wonder if Wheaton, some some of this up and and really get into this whole idea of why heatwaves a particularly damaging for wildlife. I think people can see in the green spaces around where they live, how that turning Brown. Now, that's a real problem for wildlife because some of the plant life that's normally look shit this time of year and you're getting enough moisture is dying off, but it's also problematic for small mammals. If you imagine sort of small mammals that are nesting amongst leaf litter and bushy plants and grasses, and also they're hiding amongst those from predators so that when they wilt and die off, they're much more exposed to this sort of this great imbalance in the ecosystem. When those plants start to dry out and die. Even I was reading. And we'll even go deep Aberg deeper into the soil to get to moisture. So they'll be less available for for their practices. So everything's kind of offset by this strange temperature imbalance and it's not just on the land that have been affected on fish as well, haven't they? Yeah, they have actually, some marine researchers are really focusing on some of the effects of of what they're calling marine heatwaves and where the the insure waters which can be really by a diverse and areas of life..

cancer leukemia Kansas Iraq DNA damage Jeanne Nabet Vincent Lynch UK Edison Vic Brown Wheaton
"vincent lynch" Discussed on The Science Hour

The Science Hour

03:39 min | 2 years ago

"vincent lynch" Discussed on The Science Hour

"Take him seriously. Turns out he was right and in the courtroom, it's a similar process. But the jury is really in a tough spot because they're not experts. Well, this is the point for me. You expert and the on a RC in the EPA in these, the people are experts. It seems to me almost invidious to put jurors in that position where on the one hand, you've got someone with a horrible cancer. And on the other hand, you gotta bunch us onto papers that give them mixed message in America. Anyway, product liability, lawsuits are part of our culture, and it turns out there really quite important. Some are frivolous, no doubt about it, but some are real. There are companies that have put dangerous things in products. Either deliberately are unknowingly and really one of the only ways there aren't many ways are the product liability, lawsuits, taxi exposed. This problem that's Richard bugs Stevens on the nicest bouncing the glyphosate versus its opponent argument. Well, let's move on to another big question about cancer now. And this time not whether certain herbicide causes it, but why elephants are relatively immune to cancer being mammals and being big? I'd have to see him the elephants would be prime targets because. Let's face. It happens when sales in bodies turn rogue and they start proliferating. So surely the big you are the more sells. You have them than to put it rather simply the more likely things to go wrong. Now, we know for instance, that bigger dogs mullet to get cancer than smaller ones. So back to the elephants, their secret says research out this week is that they've somehow evolved to reawaken Agena that kills cells that could be cancerous before they have time to go on and caused any damage looking at the genetics that keeps these giants. The elephants virtually immune could hold clues for tackling Kansas in humans. The latest work is published this week in the journal cell, and one of the authors is Vincent Lynch of the university of Chicago. We can't obviously do the kinds of experiments that would one might do. For example, in mice with elephants, I can't go around giving elephants large doses of things that's post cancer and say, okay, do they develop more cancer? If we give them, you know, the trend of drugs which caused cancer or something, but we have our cells in the lab. So. We can manipulate their cells and see elephants respond differently to the kinds of stresses which caused cancer. And they do so elephants cells. If you give them a little bit of the kinds of stress which causes cancer, they just up and die. They will tolerate none of it. Meanwhile, things that elephants are closely related to will tolerate a good amount of the stress that causes cancer. So we know elephants cells are really sensitive and we found a gene that contributes to that sensitivity. So this gene when it gets turned on causes the Celtics itself, and that stops the cancer in its tracks that the cell just self destructs before it can even proliferate into a cancer. Exactly, right. So this is a really effective strategy for preventing cancer, right? So magin that some cell gets exposed to some kind of stress which will eventually give rise to cancer if that cell dies immediately than those no chance at that set will ever give rise against her because it dead. It appears the edifice must have evolved ways of switching this gene back on a gain in and therefore stopping sales kind of go into the rogue state that leads to Kansas. That's right. So what we found actually is that elephants are most closely related to things called higher axis, which are these little small, furry things that live in Africa. No one ever believes they're closing related elephants because it looks like a groundhog, but they're, they're break, list, relieved elephants. And the other thing that elephants are closely related to manatees. So manatees are big, but they're not like elephant big because we found that these three groups of animals all have extra copies of gene called lifts, but it turns out that none.

cancer Kansas Celtics Stevens EPA Agena America Vincent Lynch Africa glyphosate university of Chicago Richard one hand
"vincent lynch" Discussed on Quirks and Quarks

Quirks and Quarks

04:19 min | 2 years ago

"vincent lynch" Discussed on Quirks and Quarks

"But as far as we can tell, none of those extra copies are turned on in manatee cells or hyrax cells, and most of the extra copies aren't turned on in elephants either. So we call these these kinds of genes, pseudo genes which are basically dead jeans. They resembled jeans and they have the potential to code. Functional genes, but because they lacked the on off switch that can ever be turned on. And what looks like happened is that elephants uniquely volved nuance which for one of these genes? So we call that gene lift six because it was the sixth one on the list. Considering that the elephants relatives, as you've mentioned like the hyrax, for example, do not have this active form of life. Is it fair to say that when it did evolve this activator to be able to be turned on in pachyderms elephants that that somehow it coming to life from otherwise being dead or dormant? Yes, that's what you think is happening in Italy. We call the gino's zombie djing because when you do the visionary analysis, it looks like all the ancestrally all these extra copies of lift our de jeans and this one extra copy comes back to life elephants. And when it comes back to life and gets turned on, it causes elephant cells to kill themselves. So we call him the coined the phrase zombie because it's a dead gene, which comes back to life, causes cell. Breath now does lift have any other role in the body besides suppressing cancer. So in the immune cells in the immune system and allows cells to communicate with each other. So mean cells normally go around the body and the survey for things like pathogens or infections and lift plays a role in allowing those cells to communicate with each other and lift also plays a really, really important role in the uterus during pregnancy. So it has lots of functions not just in the mean system. How could this understanding potentially help cancer biologists? They're potentially multiple ways. One is just by having a really good understanding for how some lineages of animals evolve to be cancer is isn't might tell us something more fundamental about the nature of cancer, right? So we think about remarkably cancer resistant organisms. A couple animals come to mind elephants. Of course, they're really great models for this, but also Wales wells are giant, right? So there's a lot more whale cells that can potentially turn cancerous than even there are elephants cells that can potentially turn cancerous. So why are way. Even allowed to be thing, right? Why aren't they all swimming around with cancer? And then there are things like the naked mole rat, which is this very small subterranean rodent, which almost never gets cancer only. They're only few examples of cancer reported in this species, and there's also some lineages of bats with are very, very small body. So six to ten grams or something like that that live forty fifty years. If you're a six to ten gram animal your predicted deliver year or two. So how is it that these animals can live so long yet never develop cancer in there really long lifetimes. So if we understand how it is that these organizations volved be cancer resistant will learn something very fundamental about processes, but also will learn a whole lot about cancer as a biological process and Volusia Mary process. But if we understand how these organisms evolved to be cancer is maybe then we can design drugs, for example, to mimic the functions of those genes which helps organisms beacons resistant, and then use those drugs to. Help human disease. For example, -solutely Dr Lynch. Thank you so much for your time. No problem to Dr Vincent Lynch is an evolutionary biologist at the university of Chicago. That's out the sound of the darn raccoon. Getting into your trash. Again is a common problem for many North Americans, but really the trash panda is about the worst past. Most of us have to worry about invading our backyards. I mean, what if the nocturnal visitor invading your yard to eat your garden vegetables sounded like this..

cancer Dr Vincent Lynch university of Chicago pachyderms Volusia Italy Wales forty fifty years ten grams ten gram
Amrita Alleluia, Cardiovascular Disease and Vincent Lynch discussed on BBC Inside Science

BBC Inside Science

01:09 min | 2 years ago

Amrita Alleluia, Cardiovascular Disease and Vincent Lynch discussed on BBC Inside Science

"Whilst the doctors and the trial volunteers in London of finding out more about how the good stuff from veg helps our heart. There's news elsewhere about how elephants avoid getting cancer cells in our bodies can go wrong and end up proliferating into cancers. So intuition might say that the biggest something is the more sells it has and thus greater is it's risk of developing cancer and sure enough bigger dogs are more prone to cancer than smaller ones, but elephants have somehow reawakened gene that kills cells that could be cancerous before they have time to cause any damage looking at the genetics that keeps these giants. Virtually immune is Vincent Lynch of the university of Chicago. We can't obviously do the. Kinds of experiments that would one might do for like example in mice with elephants. We can't go around giving elephants large doses of things as post cancer and say, okay, do they develop more cancer?

Amrita Alleluia Cardiovascular Disease Vincent Lynch Christopher Primis University Of Chicago London
"vincent lynch" Discussed on KDWN 720AM

KDWN 720AM

06:32 min | 2 years ago

"vincent lynch" Discussed on KDWN 720AM

"Big things the Genesis communications network for making the show happen was, working. The dials Vic thanks. For tuning in we really. Do appreciate it don't forget to follow, us on Twitter Facebook that. After Dali show so how do we get the no cancer gene that elephants have apparently less than five percent of elephants die? From cancer researchers think they figured out why this was a study that came from the university of Chicago and elephants. Produce zombie jeans they call it can help protect the. Animal from cancer Now where do USA today they break it down they say humans and other. Animals carry one copy of a master tumor suppressor gene So we. Have one copy of this tumor suppressor so when. We, see us a cell? Go rogue a cell. Start to kind of go AWOL we've been Ken suppressant without a gene for that Elephants oh I've twenty copies scientists. Found that gene can trigger a quote zombie gene To, come back to life with a new purpose killing cells in, damage DNA Yeah. I'm a little confused by that deal I zombie I think of Walking Dead I, guess what they're saying is If there is a cell or a. Gene that, may not be active okay. Maybe a repressed or suppressed gene It could turn it into. Something that turns around and I, guess has a new sort of mission so that that's a concept of zombies zombies. Are humans that were fine then it's coming back from the dead and then turning around and. Then a nuisance that's kind of what. They're talking about here except not a nuisance and something that we want, we want cancer cells killed so cords Vincent Lynch and assistant professor human genetics at the university of Chicago, saying this is beneficial because of accident response to genetic mistakes or errors made when the DNA is being repaired. Getting rid of that cell to prevent a subsequent cancer scientists say the gene also ops elephants enjoy long lives they believe they came to existence. Twenty. Five to thirty million years. Ago And they say there were groundhog. Sized ancestors of modern elephants I don't remember my Evelyn class same elephants, pods but they said there yeah I took an evolution class I did the credits I wasn't my favorite, class 'cause I had a real tough time balancing bible and and evolution but it was cool I'm like okay. Well you know I could see how things I see the pictures again But still. Not my favorite class so researchers want to conduct more studies to find out how exactly the. Genes of elephants kill off the cells, and damage DNA then it can help humans and if we. Can figure out how to make, our body turn, around and fight off. Cancer, better in the lead to. Obviously better strategies to. Prevent entry cancer they say seventeen percent of people worldwide die of cancer and the statistics I've. Heard is one out. Of every, two. People, get some, sort of cancer now that doesn't mean died from it But one out. Of every two people we'll have, something turn cancerous whether it's little skin. Lesion whether it's breast colon prostate that's. Assuming they live long enough passed a heart attack so according to Joshua Schiffman. Professor pediatrics at the university of Utah he's an investigator at the Huntsman Cancer Institute he's as we can understand how these genomic changes are contributing to cancer, resistance then we can able to start, thinking about how do. We translate this to, our patients okay so you're, probably listening to this coin or. How do I for cancer I don't want cancer I don't want does ambi- Jean I just want to live my life I don't want to need medicine. Later I definitely don't want to have to deal with the after effects of that so mayo clinic has seven tips to reduce your risk of cancer and a, lot of, you guys already know this and you don't. Believe it when I when I tell you I don't smoke you gotta eat right you don't. Believe it but let me explain why Okay What we talk, about don't use. Tobacco we know smoking's leaked to larynx, cancer pancreatic, cancer and bladder, cancer lung, cancer and kidney, cancer cervical, cancer all sorts of. Stuff. Right Chewing tobacco to when. I tell you. To not use tobacco I I mean, I mean, avoided even second, even third, hand don't breathe, in something, that you don't need to If, someone's vaping near you get away from that, if someone's smoking a joint get away from that If there's a smoker in. The house tell them to, like leave quit smoking I. Can't tell you how many secondhand or, how many cancer cases or from secondhand You know you may not want to quit for, you well you know because I want to keep my. Weight, down and you know I like my habit and. I've lived a full life yeah but you got other people you're going to hurt So? Whether, you vape whether you smoke. Whether. You to keep in mind, new could, be causing cells to go rogue, so then you're, eating a healthy diet. Everybody hates to be told us, we got, eat healthier, you gotta healthier what does that mean well. Obviously, more fruits and vegetables okay and we're not talking potato you know we're, talking the green leafy vegetables the bright peppers that kind. Of, stuff they also found that the less the better But. The big thing is is the processed foods The more we eat. Processed foods parents the World Health Organization has found, we do have a slightly it a slightly. Higher increased risk of getting, certain types of cancer You know they said women who, eat a vegetarian diet supplemented with extra virgin olive oil and. Mixed nuts may reduce the risk of breast cancer. We also know that the Mediterranean diet. Up the heart so, we really, need, to opt for fish over red. Leaves we need to choose healthy fats.

cancer Huntsman Cancer Institute university of Chicago Twitter Genesis communications Dali Vic university of Utah USA World Health Organization mayo clinic Ken Joshua Schiffman Vincent Lynch assistant professor Professor Jean investigator
"vincent lynch" Discussed on KDWN 720AM

KDWN 720AM

06:32 min | 2 years ago

"vincent lynch" Discussed on KDWN 720AM

"Things the Genesis communications network for making this you'll happen Is working the dials and Vic thanks for tuning in we really appreciate it don't forget? To follow us on Twitter and Facebook that after Dolly show so how do we get the no cancer gene that. Elephants have apparently. Less than five percent of elephants die from. Cancer researchers think they figured out why this was a, study, that came from the, university, of Chicago and elephants produce zombie jeans they call them it can help protect the animal from cancer Now are USA today they break down they say humans and. Other animals carry. One copy of a master tumor suppressor gene So we have. One copy of this tumor suppressor so. When we see us cell go rogue, a cell, start to kind of go AWOL we've been can't suppress gene for that Elephants though have twenty copies sides that. Gene can trigger a quote zombie gene To come, back to life with a new purpose killing cells in, damage DNA Yeah I'm a little confused by that too I think of Walking Dead I, guess what they're saying is If, there is a cell or gene that. May not be active okay. Maybe a repressed or suppressed gene It could turn it. Into something that turns around and, has a, new sort. Of mission say that that's a concept of zombies zombies are humans that were about you know we're fine then it's coming back from the dead and then. Turning. Around and then being a. Nuisance That's kind of what they're talking about, here except not a nuisance it's something that we want. We, want cancer cells killed Vincent Lynch and assistant professor human. Genetics at the university of Chicago say this is Ben official because it acts in response. To genetic mistakes or is made when the DNA is being repaired getting, rid of, that cell. To prevent a subsequent cancer now scientists say the gene also ops elephants enjoyed long lives They believe. They, came to existence twenty five to thirty million years ago And they say there were groundhog sized amp sisters of modern elephants, I don't remember my. Evolutionary, class Saint elephants with the. Size of groundhogs but. They said there yeah I took an evolution class I did the credits I wasn't my, favorite class because I. Had a, real. Tough, time balancing, bible and evolution but it was cool I'm like. Okay, well you know I could see how things I see the pictures again But still not my favorite class so researchers want to conduct more studies to. Find out how exactly the jeans and elephants kill off the cells damage DNA then it can help humans and. If we can figure out how to make our body turn around and, fight off cancer better. Than, the lead to obviously better. Strategies to prevent entry. Cancer they say seventeen percent of people worldwide die of cancer and the statistics I've heard, is one out of. Every two, people. Get, some sort, of cancer now that doesn't mean we die from it But one out of every two. People we'll have something turn cancerous whether. It's a little skin lesion whether it's. Breast colon prostate that's assuming they live long enough pass a heart attack so. According to Joshua Schiffman professor pediatrics at the university of Utah he's an investigator at the Huntsman Cancer Institute these as we can understand how these Genova changes, are contributing to cancer, resistance then we, could able to start. Thinking about how do, we translate this to our, patients okay so you're probably listening. To this going or how do I predict there I don't want design be gene I just want to live my life, I don't want to need. Medicine later I definitely don't want to have to deal with the after effects of that so male clinic has seven tips to reduce your risk of cancer and, a lot, of you guys already know this and you. Don't believe it when I when I tell you I don't smoke you gotta eat right you. Don't believe it but let me explain why Okay What we talk, about don't use. Tobacco we know smoking's leaked to larynx, cancer pancreatic, cancer and ladder, cancer lung, cancer and kidney, cancer cervical, cancer all sorts of. Stuff. Right chewing tobacco to when I tell you to not use. Tobacco I I, mean I mean avoided even. Secondhand even third, hand don't breathe in something that you don't need. To If someone's vaping near you. Get away from, that if someone's smoking joint get away from that If there's a smoker in the. House tell them to, like leave quit smoking I can't say how many secondhand or, how many cancer cases or from secondhand You know you may not want to quit for you well you know because I want to keep. My, way down and I like my habit and I've. Lived a full life yeah but you got other people you're going to hurt So whether you whether? You, smoke with you to keep. In. Mind you could be causing, cells to, go rogue so then you're eating a healthy. Diet, everybody hates to be told us when you got eat healthier you gotta healthier well what does that mean well obviously. More, fruits and vegetables okay and we're not talking potato We're talking, the green leafy. Vegetables, the bright peppers that? Kind, of stuff they also found. That. The less obese the better But the big thing is is the processed foods, the more we eat processed foods apparently the. World Health, Organization has, found we do have a slightly, it a slightly higher. Increased risk of getting certain types of cancer you know they. Said women who eat a Mediterranean diet supplemented with extra virgin. Olive oil mixed nuts may reduce the risk of breast cancer. We also know that the Mediterranean diet could up. The heart so we really need to. Opt for fish over red meat, we need to, choose.

cancer Huntsman Cancer Institute Gene university of Chicago Twitter Chicago USA Genesis communications skin lesion Facebook Vic university of Utah Vincent Lynch assistant professor Joshua Schiffman Ben official professor investigator
"vincent lynch" Discussed on WIMS AM 1420

WIMS AM 1420

02:08 min | 3 years ago

"vincent lynch" Discussed on WIMS AM 1420

"Cancer when it happens and they try to understand why cancer happens in the first place so someday they can prevent it normally cells will divide when they need to and then stopped growing in the case of cancer what happens is the cells continued to divide over and over and over again and they've lost the ability to stop growing that's doctor joshua shipment professor of pediatrics at the university of utah and in investigator at the hudson cancer institute there and eventually they become so large that the takeover nor get in the body sometimes they spread to different locations in the body and if left untreated they'll go on to almost certainly kill the patient over the course of a lifetime about forty percent of people will develop cancer but what many people don't realize is that the first steps toward cancer are happening in our bodies all the time but they don't get far every day just walking down the street we are getting hundreds of thousands if not millions of mutations but our body is designed to actually eliminate those so that we don't go on to develop cancer although even so half of all men in a third of all women will develop cancer throughout their lifetime and as we get older our ability to fix those mutations in the accumulation of those mutations that nick by our dna repair system begins to grow and if you live long enough there unfortunately is a pretty good chance that you may develop cancer those are dying in your body all the time so your body needs to replace those dead cell so you know every time assault is it's replaced more or less with another healthy cell and sometimes a process goes awry and so it's not quite cancer all the way but it's precancerous cinder body's immune system for example might recognize that pre cancerous cell as not being quite right and sort of mount zion response against it and kill it dr vincent lynch's assistant professor of human genetic send organizational biology and anatomy at the university of chicago sometimes that process doesn't happen and those cells estate for example that surveillance and then they start to mutated ways that makes it much harder for your body to recognize.

Cancer investigator hudson cancer institute assault immune system assistant professor professor of pediatrics university of utah mount zion dr vincent lynch university of chicago forty percent
"vincent lynch" Discussed on Security Now

Security Now

03:11 min | 4 years ago

"vincent lynch" Discussed on Security Now

"Way but nobody thought a before but somebody figured out that if you have three x's in a row it will certainly weird perspective so some now the car goes off this off to the cliff i mean a photo of but if feels to me like but this is a very worries some very obvious problem that that we're not going to be looking out until we see some explication but hopefully by researchers who are able to draw our attention to this before it had it hits the real world but everything we know tells us that that the wade this stuff is develop the way we could become dependent upon technology is kind of premature because we want it so badly and that but that but i bet technologies we ended designing are porous it is there there's just not rigid enough did there they they they're not resilient in the way we need and to me it feels like a i is really prone to having a batter reaction when something is presented to it that deliberately confuses that i just it feels tonight that is just going to be way too easy to do and finally but darkside of all the made it did domain bal addition certificate issue what's and just the reason i titled this podcast let's booth i'm going to share a because it's got all the facts blow bold together in a nice piece a and posting made yesterday by vincent lynch who was with the ss else store and while you may he and i was also specials of his motives that's visit about that i agree with him completely so is is blog posting is all to lets him cryptic stop it issuing a pal sir tiff it gets and i'm i'm just going to cut to the chase so i don't lose any with attention here to say that let's in cryptic has issued is everybody sitting dabbling are you saturday over your by all my ball baby nine hundred and eighty eight to win so hey pal certificate secure when there can be but one that we like to be a per that might be a problem yeah yeah exactly golden one valid one as as he says dater shows widespread use of certificate sport fishing this is an open letter he rights to let's in cryptic regarding it's issue once absurd terrific it's containing the word pay pau within the yes so so slash certificate up jordy industry there is an ongoing debate about ss sell certificate sfor malicious.

vincent lynch pau