22 Burst results for "Two Effects"
"two effects" Discussed on KZSC 88.1 FM Santa Cruz
"Is roadwork blocking Elaine the delay still begin right around the deptford mall Traffic every 15 minutes next report four 48 I'm Susie Cerone on New Jersey when 1.5 New Jersey 101.5 instant weather fueled by a southeast wind dew points and humidity levels will slowly rise over the next day or so and we'll see two effects of that overnight increased cloud cover and it's not gonna get quite as chilly as last night I think we'll bottom out around the 60° mark by tomorrow morning still comfortable still pleasant we'll call skies partly cloudy And tomorrow we will see some cloud cover and some sun should be a nice day highs lower to mid 70s and then Wednesday a chance to spotty showers developing It'll be mostly cloudy breezy and humid high pop to near 80 On Thursday at some point is slow moving cold front will move through with periods of rain the timing of that is still a little unclear There could be some heavy stuff maybe some rumbles of thunder behind that front a little taste of fall air coming by next weekend From the Edison heating and cooling weather desk meteorologist Stan zoro Island heights Well it's 73 but I was supposed to say Harvey cedars 74 hope 75 Hamilton 76 review I owe you a town later Doyle Fast traffic and instant weather every 15 minutes on New Jersey 101.5 Four 38 with deminski and Doyle so what do you think Should transgender girls be allowed to play on girls teams one 802 8 three one O 1.5 Let's talk to Matt in White House station you're on New Jersey 101.5 Hello Hello mat how are you Good how are you doing Okay.
"two effects" Discussed on KGO 810
"Medicare. Medicaid is an outstanding question, something that HHS will have to deal with. And so we're going to have to figure out how do we get this very needed drug Into the benefit of the patients who so desperately need it. And how do we do it without breaking the bank on a federal level? To talk about all this and more. I'm very happy to welcome onto the program. My good friend George Rottenberg. He is chairman of us against Alzheimer's one of the leading organizations in the fight against this dreaded disease, George, thanks for joining us on the program. Thanks, Rick. So, George, talk about your reaction first to the news of the FDA approval and now the more sobering element of the economics, the implications of what all that means. Well, we reacted quite positively to this announcement. It is a real sort of break in the history of Alzheimers, which, as you noted, has not experienced in a significant movement in treatments in basically its entire course. Some symptomatic drugs approved about 18 years ago, but no disease, modifying drugs, this drug Actually modifies the course of the disease and has shown significant evidence of the clinical benefit. So this is for the patient population, a breath of fresh air, a degree of hope over what has been a system where we have not had any treatment for EMC and, indeed no disease modifying treatments for this disease. So it's good news for patients. No question that this is not a cure. This drug will slow the disease them if you take it, and in your mild cognitive impairment stage, the estimate, maybe a year and a half for two years holding you at a functionally stable level. And as a consequence, you would then proceed to progress through the disease. But hopefully in two years we're going to have another drug that will pick up where this leaves off and thus provide a bridge for those people who take it now to get to the next drug. As a consequence of this announcement, Eli Lilly has announced that is going to seek FDA approval by the end of this year on its drug, which initial evidence suggests it will be stronger than this. The Magic Kingdom have drug and in fact, we all have a stopping rule. That is a rule that you can stop taking the drug after a period of time. So this announcement had two effects one and gave some hope to patients who really want to be co sort of investigators on what drug works for us and when it works and how it works, and it's also stimulating competition and innovation in the space. In a way like we have experienced with cancer but have never experienced with Alzheimer's. Most cancer drugs are approved on this kind of regulatory mechanism, and we've made enormous progress in cancer. Thousands trials compared to 100 for Alzheimer's, and so we're excited about this. The starting gun The end of this disease. It is the starting gun. Not the ending gun is the first in class drugs, not the lasting class drug. Let me share with you, George. My my view on this. I I kind of take the attitude that I think that what the FDA did, and at least part Is basically threw a bone to the pharmaceutical industry, saying, Look, you're spending billions of dollars decades of research and this drug is I'll put it in the good enough mode. As you said, it's not a cure, but it does. Demonstrate, apparently at least some efficacy for some patients, and that is enough considering that Alzheimer's patients have had virtually no support and assistance in pharmaceutical interventions over the past couple of decades. And it's providing a shot in the arm to other pharmaceutical companies to say, Look, Let's go forward with this. As you've pointed out, I'm not sure that an Alzheimer's patient paying $56,000 a year for this drug He's going to pay 56 grand a year every year for the rest of their lives, because over the rest of their lives were going to come up with other treatments that are potentially going to be a lot less expensive. I mean, just as the prices of computers have dropped over the last 30 years. The prices of these drugs are probably going to come down over the next 30 years. Um, so in the meantime, we can help patients who need it while setting the stage for more radical advances in the field that will ultimately lead to the eradication. Am I totally off base with that? No. Although I would not say.
"two effects" Discussed on What Goes Up
"You have to ask yourself as an investor. Do i believe the expected a return for this asset classes twenty percent. That seems awfully high. Any we would look at that and say a good portion of that was an unexpected component of the return. That might have been based on you know great success for some of these companies it could have been unexpected to a certain extent certainly when you look at evaluations they were creeping up. They were still are very very high. So when i think about is the question of is there. Any juice left squeeze lemon. My question would be what's changed by your expectation for the value premium. As long as you believe that low prices associated with higher expected returns. There's plenty of juice left a squeeze because we still expect value premium every single day. You know us. I'm curious how you approach fits in with the year like this You know. And i know being anchored in sort of the academic Approach a of investing and and very much anchored to the efficient market hypothesis at dimensional. Then boy we enter a year like twenty twenty one right and we've got all of a sudden the the discount brokerage is just completely get rid of commissions. You've got all these people stuck at home. They can't go out. They can't bet on sports. You know they've got a lot of spare cash whether it be because of that or because of the stimulus From the government. And what not and we have this phenomenon like the red sox just going going absolutely nuts and it's hard to for me to sort of wrap my head around how a a student of sort of efficient market theory could can kind of operate in that environment. I mean does it. Change your approach at all to see this type of behavior and half-jokingly i ask. Is there perhaps. A reddit factor. That can be exploited you know. Is there a wall street. That's factor that you could somehow quantify and try to play with and feel free to tell me i'm crazy for thinking that i've heard it before but i'm just curious how you think about a year like this with that academic background that efficient markets theory background with the market. A lot of times is being driven by day traders. You know placing trades based on what they read on reddit and what they think the crowd where they think the crowds can go. Next i think it reinforces the need for flexibility within your investment approach in having a daily process so when we look at the price change for individuals securities. I mean we know it can happen. Because of maybe a change in the expectation for the future for the cash flows of the firm. It could reflect a change in the discount. Rate that's assigned to those expected future. Cash flows very difficult if not impossible to disentangle those two effects but what we do know is that when price is higher expected returns or lower. So we're that's relevant is if you have a strategy like say that's focused on small cap value stocks. Well if you have a company like one of the ones you're mentioning start off a small cap value and all of a sudden it's prices now making it. One of the largest two or three hundred companies in the us will then at that point. It's not really fitting. The definition of higher expected returns in accordance with a small cap value portfolio..
"two effects" Discussed on Roleplay Replay
"Spell the two bonus action. i can't do as spell. That's an action correct. You can if it's canter to write out it takes six point five damage I'm going to do fifteen when teen and As a pass by mirror. I don't really have any cold damage but i do have this when the cast guiding bolt at the big guy that would do it at second level thirteen. A third thirteen will just hit now role to one So thirteen radiant damage thirteen and it's already incorrect. Yes okay he will take thirteen points of radiant damage and you watch at the center of his flaming form. There is a dark grey. Orb of light that seems to glow and pulse eight out from his chest. Anything else you'd like to do fan. I'll live mercy with me now. She s okay. Fanton can you talk to me about how. Calm emotions works. The character has failed attempt to suppress strong emotions and a group of people If it fails it can do. One of two effects can suppress any effect causing target to be charmed or frightens when the spell ends any suppressed effect resumes provided that its duration has not expired in the meantime so And it is concentration for up to one minute okay. Can you to concentration checks for me. okay Let me tell you. Can i finish raden true. Sorry alternatively you can make a target indifferent about creatures of your choice that is that it is hostile towards dan. Difference ins if the target is attacked or harmed fest spell or witnessed any of its friends being harmed with a spill ends. The creature becomes hostile again until the rules. Otherwise so a concentration check. What's that can be. It's a constitution saving through. You just need to beat at ten. And i think it might only be one. I think you've only taken damage once. Cool so you're good to go all right so anything else. You wanna do thin all okay. So at the top of ause is turn. Unfortunately you all watch as this place gets crazy again and as that happens. The dry add seeing grove in this state again. You feel like pulling against the spell. And i'm gonna have the dry add. Make the check again as a reaction as though she took damage or you took damage because this is a catastrophic event for her and it's a charisma save so i have to the table. Sorry so this is a plus four. Okay so you you you hear this sort of like. It's not the same kind of super raw scream like you heard. when she. i flew out of the tree. This is much more subdued and almost almost beautiful but there's like a rage in it and you look over and you see her grabbing her head but she's continuing to focus on the peace that you've planted in her mind and she remains in this form even as the landscape has changed us. Would you like to give them a water. Gonna now i'm gonna care. Beam the golden guy. Okay role that six again and What did what did he get. The first time it was four right yes. Four plus one ten point six for six. Okay nice so that's ten total now two hundred points okay. At this point. They're still doesn't seem to be enough of a change but you get a sense that what you're doing is definitely having an effect on his form then with my action See i will. I'll past a second level healing word on him a second level healing word. Okay go ahead and roll the roll. The healing nine points that brings total to twenty urge in one thousand nine. Okay cool Oh is i'm really sorry. You can't do both of those on one turn. Those are both bonus actions. I'll write healing. Word is a bonus action. Okay but i will. I will let you choose which one you did. I'll do the niner okay. We're up to thirteen total so you can take that You can take that bomb. The summer quarterback okay. Yep catch thank you anything else. Ause let's see. I still with an action. I'm just gonna use sharp water to try. And swirl around some of the water out sheerest is just react. Okay is shape shape. Can't trip this okay. So as you start to move it around it does react. It does appear to be water and yet that'll be my turn. Okay so wreak at the.
"two effects" Discussed on Talk Nerdy to Me
"Die. He became an lynch. Okay illitch under wizard type thing so he was a powerful wizard. The trust a lot of his administrative tasks to his lieutenants cast ks and he gave him the source catch promise overcast was infused with So is slowly started turning in bad to the point where he turtle becca and one of the power for yourself so he ended up trying to get rid of. It did work. He got banished. And you know he tried to try to become it. He wanted to be so that equipped workout banished also but before he was vanished blues cabinets. He ended up losing left hand as i. That's all it was left before he got sent. Who speak is the will. So these two artifacts. I guess you'd phone parts of his body. The left behind still had quite a bit of his power in them so much. So that if you if you had them view you would have their power and some of the stuff. What the gruesome part is to use the power. The person had to cut off their left wrist and hold a hand up to their you know was left with their arm in it would fuse to their arm and caused them to give all the powers. Glasnost like in. Make sure to missing Yeah the hand had such powers like finger death sleep slow teleport and then the i also had its own powers. The i gave you immunity to disease poison premonitions of best of getting ready to happen. It could turn other people skeletons to and it can also allow you to regenerate somewhat then every thirty days it was also able to grant cast wish another bill warring on her face. You don't put over your head and breathe a problem for small children an emphasis so but if you're giving your infant hanae cnas toy there's more serious problems we need to deal with not not something. You would typically see in the mobile above the babies. So as i'm trying to get something history as i'm in boxing. This here for you. Like i said in order to use the power of the hand you had to cut off your left hand and replace it with now in order to destroy the hand and eye avec nut. They couldn't be destroyed individually. Have you tried to destroy him. that way. they just ended up teleporting to a secret vault where they would stay until they were discovered again. The only way to destroy them is to kill whoever has them. They have to have both of them though. If you kill both people who have them with the sort of cause which is you know. The the sorta he gave to his lieutenant which end of against the only way to take it out of He was pretty powerful. He also was able to eat not able to. He did right. He was the first author of the book. Vile darkness other wizards added to it later. but he is the first author or what i have done. So far is a low wire frame. bits go to support the hand and is this pop into the two little holes in the base. We wanted to look all artifacts. So we're gonna cover it with this kind of bill ridiculous to behind the the wire frame deal. I have a feeling this is gonna prove to be a pain when we try to put the glass top on. But anyway we're gonna take the hand and it's a solid. I'm guessing some type of ceramic Doesn't really say was made out of boom so we're gonna place the hand that's the easy part in the eyeball pretty gnarly looking eyeball Beca could use some by zine okay is got it in between his his first finger and middle finger and the thumb kind of a tripod solicit we all at that but the hand is a little pliable rubbery type filter. So we just kinda logic in there. This is going to be interesting and now we got to put a complete display. It's got a glass dome artifact it is so we're gonna put that there and there are some finagling you can do with the little piece of cloth especially if you have smaller figures. My big clumsy ones look at that. that's nice. Yeah one of the bigger dandy pieces. I guess they're doing artifacts. I've have another one or two effects coming out soon. Had an ejecta as the. I'm han hi into nine. Which everyone say. I is the first one as you can see. It's a pretty as a presence. It's almost twelve inches tall. It's pretty detailed. Got old withered hand. You're the gnarliest an eyeball there. You got the really cool museum looking glass dome to put it in is actually glass yet do you have. This is a even. If you're not into the it look good old off these these Maybe even back light in a small led just to cast a shadow something but right out of the box it looks. I'm really liking it. It's really impressive. It's a little pricier. The law the other stuff. The this is a hundred fifty bucks But if you're begging d. and even if you're just into creepy stuff this definitely fits the bill this is this is really cool especially when you learn some of the history behind vikna. He was a he was a bad news Once they use the power you have to cut your hand off in a let us to your your stop and it gives you all all the power of the hand It also kind of makes you shift your character to a neutral evil Type character basically evil. Because why not you will for the sake of evil.
"two effects" Discussed on On The Table Gaming
"Reworked or changed in addition to that one of the initial design ideas behind the bratty de had these powerful effects but a lot of overlapping triggers. And while still that's a that's an option for gameplay found allow players just a created negative play experience for them that they just this. This didn't really come down to a balancing factor. It just kinda came down to like the whole feels bad. People want to be able to play their tactics hearts. You can have a de powerful effects of only if you're only able to use them every so often than people don't view that as basically being as writing as being able to play triggers more often even if they are less powerful so it's kind of like instead of going like hey i've got these two powerful effects that can choose from. The mentality is almost like oh. I've got these two effects. And i don't get to use one exactly so one of the things when we were evaluating the breath deck specifically is removing some of those overlapping triggers and giving them some more options for playing things which in turn tone down some their cards which you see in general across most the factions. Anyway but so again they required a little bit more just re tweaking than some of the other factions. Did that makes sense. And i think that's something that Some players had a hard time adapting to initially something. Maybe like you mentioned kind of created a little bit like feels bad moment or maybe you know the way. That situation presents itself is open to interpretation. That isn't as positive and so now with these new tactics kind of spread the love and it looks like you also may be shuffled. Some names around or abilities around things. Like oath of duty are now appearing in the base deck which i believe previously was a status card. It was in the original of the starbucks status. The one true king and this is just kind of one of those effects that happens as we're evaluating the entire faction in the entire game overall it kind of creates those little ripples or snowballs. Were you know okay. You change a which is going to have effect on be which is had an affect on c. Which the change from c. Is not going to go back and change an employee different ways. So you're talking about these things in a vacuum. It's hard because like you'll you'll talk about like okay. Well why did this baseline tactics change while the change because we felt that this commanders card we evaluated him. That card didn't really sort of him but still uneasy effects so therefore it got moved over here and it's entire process that stacks on top of each other win. All these things start coming together. Is there a base barath tactics card that you're particularly fond of in the twenty twenty one update. I would actually have to say that ours is. The fury is probably like one of the most powerful kurtz that's because of the versatility brings if we had to. That's a tricky question. Because again the tactics there shouldn't be one that is really like this. Is the thing that really solidifies. Ms the faction because its entire picture taken together but i do like for example ours. I think the versatility you have there. That's pretty sweet right. So now when a friendly units performing mainly attack before we roll the attack dice. Negative choose one and then for each zone you control among the crown or the letters zone you get to choose an additional effect so if.
"two effects" Discussed on The Agostinho Zinga Show
"When you go and see someone playing in imax courage in in the yard in oval space in was was place in south called fucks these kind of places they should behave and safe havens for you to go and enjoy the music and leave without feeling like you have to kind of cover over john j. I mean the you'd imagine how the dow thing. And i guess maybe with these stories being european day will basically help to drive a conversation and make guys moral aware really hope so that people kind of take this saheed again. I don't know it's just toughen. Imagine just imagine a youngest picturing that seventeen year old rebecca going door trying to get an internship and then being told that license i got damaged. People are horrible people. The horrible continued from echoes. Quote action was heard associated. Initially music released an industry code of conduct in november and of industry bodies have been developing own pledges to hold abuses accountable for the actions. Decrease safest place for club as industry looks to reopen into in twenty. One as i meant of fremont is trying to break into Says she feels obliged to continue pushing for change. Can we live with ourselves to keep bringing more women teachers and producers in knowing that this is going to happen she says i can't and i think we're really strong now. This is like an army. This has to speak volumes. She definitely true regarding that. So yeah hopefully speaks volumes go and ford and we do kind of continue that conversation. We do continue to mccarthy chavez a dance floor because if we don't who else is especially in the uk to offer like that's the problem we have here because we don't have pickers we don't have that selection picking thing that they do. They have a continent such just a difficult. I mean like. I dunno hopefully hopefully hopefully to the messages of heated off the of these articles and people make some level of change anyway. That's excellent english. Upset number forty two effects also tuning in as you've been a pleasure to have your company s i'm going to show you may say smith lapa hit subscribe coined below if his class at pleasing before you showed your friends and of course. A poor pitchers myrna welcome at patient. Comforters agostino pitching convoys eight g. o. s. t. a. h. o. Getting both there. And i'll see as again very very soon take piece by..
"two effects" Discussed on KOA 850 AM
"It on his first try. But today he brings us some formation a leadership stories from his younger days starting at his high school. Culver Academy that cover my first year. I got beat up a lot on grassed a lot. Uh, And when I was a cover, some of the advisers told me that I couldn't get into my tea. And then when I got into M I t I said, Well, you know you're at the bottom of the class. You know, I don't think you'll make it And then I found out that if I wanted to do well, mainly to impress my father As well as men, Lee to develop my own skills and my own accomplishments, So I just would work very, very hard. You know if I had to go to the bathroom, I take us Ah, book with May so I worked really hard and then I graduated with top honors. And then I got my God, Trista Gary from it, And I've always been seemed to be told that I can't do something you know, being harassed on told I was dumb and idiot, some other things. So that has become a big challenge for May. I mean, you could have two effects. Either you stay unnerved the rest of your life for in any of the rest of your life for you Take advantage of it. In fact, you know, I probably have a little O. C D on. I looked at it and said, Well, that could either kill me or I could use it to an advantage, so I used it to work very hard. Then. Surprisingly, I got more honors and all my brothers put together just made a couple of test but I am wanted to play basketball. I thought this work was terrific. Then in our freshman year,.
"two effects" Discussed on WTOP
"Only $99. Traffic and weather on the AIDS to Rita Kessler in the W. T o P Traffic Center. Watch for delays in Virginia on North Bound 95 after 2 34 and dumb freeze trying to head into Dale City. It is at the Dale City Rest area. The crash along the right side, also westbound old Bridge Road between Tenured Hill Road and Clipper Drive. It should be a single lane getting you up to that utility work sown at Clipper Drive. Also watch for two effect. Clipper Drive as well. Symington Road in North Beauregard Street in Alexandria is Report of a crash while in Maryland, getting Acosta Harry Nice Mac Middleton Bridge Today, traffic alternates across the bridge for the work. The westbound span of the Bay Bridge. The left lane of three is blocked with the work and the Baltimore Washington Parkway North bound, moving from 1 97 all the way to 1 75. Today That's the mobile street sweeping crew along the right side South bound on the parkway near Route 100 was a report of some debris in the roadway east on I 70 near Maryland, 56, or big pool. The crash had been along the right side and we also Add 4 50 westbound near the Beltway Watch for the response there for the crash. Eastbound 100 year Randall Mills Boulevard There were broken down vehicle was reported to be along the right side. 2 10 Year the Beltway, a report of a crash and in the district inbound New York Avenue on the Anacostia River. The right lane was blocked with the work zone. W T o P Reporters. They're different by Fitzgerald Auto Mall shop fits first and save money on New Toyota Sundays and Subaru's visit fit small dot com Transparency You can trust I'm Rita Kessler. W T. O P Traffic and now to storm Team four. Meteorologist Lauren Rickets Temperatures today you're going to continue to climb into the mid to upper sixties. What a beautiful day that.
What happens if online advertising is just a big, fat bubble?
"So. Big Tech monopolies are in the news this week the Department of Justice sued Google over how it maintains its search dominance and it search dominance is the key to its business model, which is that it makes eighty percent of its revenue from digital advertising facebook by the makes ninety, nine percent of its revenue from advertising and the profitability of targeted ads is also a big reason why tech companies are constantly collecting so much data about us and there's a multibillion dollar ad tech industry that exists because all of this makes so much money. But what these ads didn't actually work all that. Well, Tim Wong is a former public policy executive Google where he worked on artificial intelligence and machine learning and he's of the new book subprime attention crisis I. Think this is an interesting important distinction right? which is it's not necessarily to make the argument that advertising never works categorically right? We have examples of it working. The question is whether or not the market as a whole really lives up to the promises that it's made and the promises made is that data driven. Automated form of what's known as programmatic advertising is a kind of advertising that's way better than billboards or magazines or the kind of madman style of advertising and I think ultimately, it may be that we are exactly where we were decades ago. Right? which is we actually don't know which half of the money spent advertising works in which one is wasted. We just very difficult to tell. Is, there an awareness of this? I mean I know that you know after for example, Cambridge Politica, there was a lot of conversation about how there are lots of promises related to micro targeting and that it just might not be. Realistic. Like do advertisers are they starting to understand this? Well, I, think there's a lot of willful blindness in the Advertising Space you know so this book that I just wrote, it opens on a really strange experience that I had going to a marketing conference where a professor laid out all of the evidence right? You know sixty percent of people never see ads ad blocking up all around the world it was just dead space the. Advertisers kind of refuse to engage with it, and you know it's one of the things I've been thinking a lot about because it's similar to patterns that we see and other market bubbles right where there's these deep structural problems with the industry. But a lot of the people involved either don't want to hear it or they don't believe it I mean listen I'm very familiar with the idea of the belief that technology must be working even. All. Evidence to the contrary. But I do want to ask you about targeting specifically because it seems like there's a lot of technical reasons it doesn't work. But what about this idea that there's a massive amount of data collection that ads can be so specific and personalized that you literally cannot resist them are you saying that's also not true Yeah I. Mean You brought up Cambridge Analytical earlier? I mean there's a fascinating report that just came out from the UK privacy regulator that was basically their research to say look there's all of this kind of. Metric advertising does it make a difference and the conclusion? There was no there actually was not any significant difference and there's two reasons for that. One of them is a lot of researchers find that a lot of the data being used as faulty and messy and doesn't work and I think the other one is whether or not. This data actually helps you to target a message better is really unclear. There's a great researcher by the name of Allesandro. Who's been doing some work on if you have targeted ads versus non targeted ads, does it actually make a difference and conclusion is it does but really only by a small margin, much less than you think. Could it also expose the fact that a lot of these companies no longer want the data for advertising like they want it for machine learning. Yeah I. think that's ultimately you know I think one of the great questions and responses I've had to the book is people say so why have we built this enormous surveillance infrastructure? This thing just doesn't work I. Think people have traditionally thought. Oh, well, it's because Mark Zuckerberg wants to build a mind control ray that's his advertising system. You know the reality is that it has been collected for other reasons and for sure I think things like the promise of machine learning is is one of the reasons that people collect this data. What Can. Be Done. Do you think I mean? This is a big complicated technology question. You've got companies spending a ton of money and companies that rely on this for their whole business model. Like what could solutions even look like? One of my worries about this is that again, if you study the history of market bubbles, a lot of what we see is very reminiscent right to the say the subprime mortgage crisis of two, thousand, seven, two, thousand, eight, and there is a momentum here in the problem with bubbles is that. While, it may look great in two, thousand, seven, I think we were saying how great economy is doing. At some point they pop and I think the human costs will be great. It's really not just a matter of whether or not you know Mark Zuckerberg has less. Fewer billion dollars right I think you gotta think about all the media that's relying on this ecosystem that journalism that relies on it and many other places that advertising touches online, and so I I tend to believe in the idea that we have to find ways of deflating this bubble and so I'm really interested in kind of the ability to both spread the public word about some of the problems in this marketplace. But also I think there's room for regulation I. think There's room to enforce transparency in the marketplace to try to make sure that you know expectations about this match up with reality. There's been just as a regulatory matter there been a lot of questions about banning targeted advertising. Should that happen? Yeah I I do think. So and I think in some ways you know in may be the thing that pops the bubble right because for the longest time, advertisers have been basically holding to the position that we need all this data order to do our business to target our ads and what we're seeing as things. GDP are the European privacy law and CPA to California privacy law rollout is in many cases the market just keep chugging along even though our advertisers have a lot less access to data and I do think that that kind of realization that all this data might actually not have been very. Meaningful might actually 'cause you know sort of expectations or perceptions about how great this stuff is to kind of crash to Earth, and so you think these privacy laws have these two effects. One of them is to protect privacy, which of course is important but I think the other side of it is actually in May of like you know strip the veil off this market that I think has been kinda shrouded for so long Tim. Wong is the author of the new book subprime attention crisis. How big a bubble are we talking here? Digital advertisers will spend over one hundred and forty billion dollars in the US in twenty twenty.
How Bolton's Allegations Could Change the Impeachment Trial
"It's the second week of the Senate impeachment trial of president trump and there's a new wildcard in the mix John Bolton a draft of the former national security advisers memoir was leaked over the weekend in it. He reportedly writes that. President trump told him he wanted to freeze aid to Ukraine until the country. Aidid investigations into Democrats including his political rival former vice president. Joe Biden the allegation strike at the center of the impeachment inquiry and could change the dynamics in the Senate or the President's defense team is making their arguments today. Joining me now with more details is Wall Street Journal Executive Washington editor Jerry. seib Jerry this leak from John Bolton's upcoming book is throwing a lot of uncertainty into the Senate impeachment trial. Democrats are renewing their calls for Bolton to testify and it could prompt president trump's defense to tweak their strategy. How do you think this could change what we see in the next few days of the impeachment trial well I think it has to immediate impacts one is I think it affects or could affect at least the tactics? The president's defense team uses as it moves through its phase days of the arguments in the Senate it has been essentially trying to have it both ways to say there was no quid pro quo when the president asks Ukraine for Investigations Investigations into corruption. In the Biden's there was no threat of withholding military aid at the same time so there was no quid pro quo. But and secondly even if there there was such a quid pro quo. It would have been perfectly within the president's rights to ask for that because he was interested in getting to the bottom of corruption Ukraine. I think now that you have John Bolton saying saying well yes there was a quid pro quo. The president told me that he was going to withhold aid until the Ukrainians started investigating the Biden's that now I think the president's defense team probably has to fall back on the well. That was perfectly acceptable argument. So I think it changes and somewhat restricts their ability to argue their case the second effect and probably conceivably conceivably the more important one is that it increases dramatically the chances that there will be a vote in the Senate to call witnesses once. The President's defense team has done making. It's case in to do that. You'd have four. Republican senators agree with all the Democrats. Witnesses ought to be called including John Bolton on Saturday. That didn't seem very likely Egli to happen on Monday. After the Bolton revelation. I think it's much more likely and that in turn I imagine could open the door to calling more witnesses besides Bolton right exactly exactly because once you open that door there are a lot of things that can happen and the Democrats are equally eager to hear from Mick Mulvaney. The Acting White House Chief of staff and Secretary of State Mike Pompeo will potentially others and then you will have Republicans demanding that Joe Biden or his son. Hunter Biden be called to testify about their actions in Ukraine rain. And so you have probably dueling subpoena fights and elongation of the whole trial section of the impeachment process which the president doesn't want and very uncertain outcomes the law of surprises and potentially unser pleasant surprises for both sides. Comes into play so you will have moved from a process is that seemed to be headed toward a certain conclusion to one in which there's at least more uncertainty. I think it's very unlikely that. Any of these scenarios result in the president being convicted hidden removed from office but the twists and turns in the political impact list twists and turns are much harder to predict now. How damaging could Bolton's testimony for the president in this trial if we go down that road where he is called as a witness well I think it's damaging potentially in the sense that it will Would serve if the if the leaks. What he's written? A book are correct to basically confirmed one of the articles of impeachment that the Democrats have put forward which is that. There was undue undue pressure put on Ukraine in the form of withholding military aid to coerce the Ukrainian to investigate the president's political opponents. That is Joe Biden. That would essentially Ashley be confirmed if the leaks are correct. It doesn't however get to the follow on question which Republicans would stress. which is? That's not an impeachable offense. You may disagree with that. We think the president was in within his rights to press for an answer to what was going on in Ukraine during the Obama years as a matter of foreign policy and so what Republicans will say. It's not an impeachable offense. Even if you believe everything John Bolton said so I I think it complicates the political narrative. I doubt that it changes inches. The outcome as I said because Republicans are both convinced there there was less there the meets the eye and that whatever the president did does not amount to a high crime or misdemeanor meaner as required under the constitution for impeachment and conviction Jerry. How do Republicans view John Bolton he has a long history in Washington how are Republicans responding responding to this leak? And how are they viewing Bolton's relationship to president trump. Well that's an interesting question because you have a role reversal in both parties. He's on John Bolton right now. For years and years John Bolton was kind of a a villainous figure in the Democratic Party very conservative goes back to campaigning for Barry Goldwater when he was in his youth served in the Reagan and Bush administrations very hawkish conservative and very much reviled by Democrats now. They're begging for John Bolton to stand up and be a man of principle as we know he is and testify and on the Republican side. You have a similar reversal. I mean John Bolton is conservatives conservative he served in every Republican administration nations since Ronald Reagan. And now he's being attacked by. Republicans is not credible person and so this is kind of the whiplash effect that you see often in the the trump administration when people who were traditional Republican conservatives are not necessarily trusted now and those same kinds of conservatives. Don't necessarily love the trump administration association. So there's a kind of identity crisis on the right to to some extent these days and John Bolton personifies that now in this context in some ways you know one of the ironies. arnie's in this situation is that there are a lot of things that John Bolton has said and written for years that are very trumpian in the way he's described it very much in sync with President and trump. He has said you can't trust the European Union for example and he has said the State Department is a A hotbed of careerist liberals who try to make policy not just execute the president's policy especially when that president is a Republican. Those are the exact things that Donald Trump says about the EU and the State Department bureaucracy. So there is a there's there's a lot of overlap between John Bolton things and what Donald Trump thinks the place where they fell out with each other and the reason for this controversy now is Moscow in Russia Russia where John Bolton is quite the Hawk and therefore wanted to make sure that Ukraine was armed to confront Russia and president trump has a much more benign view of Russia and Vladimir Putin hooton overall and so the irony here is that there's a lot of trump and John Bolton just not on this question of Ukraine Wall Street Journal Executive Washington editor Jerry. seib thank thank you so
What is a neutrino?
"This person wants to know and can you help please friend what is a Neutrino. Yeah that's a good question. Neutrino is a very very light party. Call is one of the particles that the standard model which means we're very short exists. It is produced in radioactive decays and around a hundred trillion. Neutrinos pass through your body every second. But because that's so weakly interacting acting they just go straight through and you don't notice them to detect even handful of neutrinos. We have to build huge and very very sensitive detectors. Chris but they're actually that all around us they come from the sun they come from nuclear reactors. They were produced in the early universe. So they're just everywhere so are they actually part and parcel of an atom or the only produced when radioactive event and atom decays resulted in the particle whizzes off. If the latter what's is there alternate fight then there are only produced in a radioactive decay as you say when produced by the atom they whiz off and we didn't really have an ultimate fate. They just I stream through the universe. Forever doesn't mean the number of them is therefore theoretically permanently increasing indefinitely yes but space is expanding expanding so more and more being produced but that also being diluted by the expansion of space but the number of neutrinos out there is going up all the time on three radioactive decay and then then GonNa turn into anything else. There's nothing else that can do once. They're neutrino they do occasionally turn into other things in a process. That's like the inverse inverse of radioactive decay. Quite know how those two effects balance out my guess would be the whenever radioactive active decay happens some decays always producing neutrino whereas won't see Neutrino is that it's very rare for it to interact with anything anything so my guess would be. The total number between Os is always increasing. But I'd have to go and check out to tell you for sure and if you know different than to let us know thanks for that friend.
"two effects" Discussed on WTMJ 620
"The little guy trader Joes compete at such a high level psychologist in trader Joe's enthusiast Perry Schwartz coined the term the paradox of choice in quite literally wrote the book on it the paradox of choice why more is less here he is to explain what he means all this choice has to affect to negative effects on people one effect paradoxically is that it produces paralysis rather than liberation with so many options to choose from people find it very difficult to choose at all that's one effect the second effect is that even if we manage to overcome the paralysis and make a choice we end up less satisfied with the result of the choice then we would be if we have fewer options to choose from there are several reasons for this one of them is that with a lot of different salad dressings to choose from if you buy one and it's not perfect and you know what salad dressing is it's easy to imagine that you could have made a different choice that would have been better and what happens is this imagined alternative induces you regret the decision you made and this regret subtracts from the satisfaction you get out of the decision you made even if it was a good decision I had no particular expectations when they only came in one flavor when they came a hundred flavors one of them should have been perfect and what I got was good but it wasn't perfect finally one consequence of buying a bad fitting pair.
"two effects" Discussed on 90.3 KAZU
"Result is Monday Tuesday the twenty third of September that is always to have you along everybody we begin today with a little bit of well that's good. I think according to the people who keep track of this stuff which in this case is the US department of commerce Americans are saving more so far this year we are saving more than we have since before the recession which is good I think because something's going on here usually when an economy is growing as the American economy is people sable less not more but here we are in the longest economic expansion we've ever had. or save it market places in dealer has this look at what's going on if people are saving money they're doing it for two main reasons retirement and if they're uncertain about their economic future what we're really seeing is more the second effect happening that's against matters he's an economist at the Wharton school of business people face a lot of uncertainty you know about the future and people are at increased their precautionary saving he says were also only ten years removed from the Great Recession so people could still be scarred from that the propensity to save breaks down by income level higher income households in the save more those people also benefited more from the tax cuts and jobs act of twenty seventeen mark Zandi is chief economist at moody's analytics big chunk of that tax cut for high councils which is wanted to peoples savings accounts and this saving is happening at a time of unprecedented economic expansion so it seems the fruits of that expansion are really getting to a lot of lower income households and while saving is generally encouraged if it outstrips investment over the medium or long haul it could backfire get the ecards and teaches economics at Brown University investment which is going to be mostly the same as savings is not really taking up much better so have given rise to worries about book people of termina sectors technician he says conventional wisdom is that the government can step in and stands to help stimulate the economy now this could happen via a stimulus plan or infrastructure spending but that of course also has a hefty price tag I'm a dealer for market place look the economy is complicated just witness that savings rates story and adjusted for us right and we know that sometimes try though we might to help you understand it we throw business and economics at your pretty fast so today the new series in which we slow way down and go back to basics were calling it this is not my idea we're calling it hi explains..
"two effects" Discussed on WNYC 93.9 FM
"Is Monday Tuesday the twenty third of September that is always to have you along everybody we begin today with a little bit of well that's good. I think according to the people who keep track of this stuff which in this case is the US department of commerce Americans are saving more so far this year we are saving more than we have since before the recession which is good I think because something's going on here usually when an economy is growing as the American economy is people sable less not more but here we are in the longest economic expansion we've ever had. or save it market places in dealer has this look at what's going on if people are saving money they're doing it for two main reasons retirement and if they're uncertain about their economic future what we're really seeing is more the second effect happening that's considered season contest at the Wharton school of business people face a lot of uncertainty you know about the future and people are at increased their precautionary saving he says were also only ten years removed from the Great Recession so people could still be scarred from that the propensity to save breaks down by income level higher income households in to save more those people also benefited more from the tax cuts and jobs act of twenty seventeen mark Zandi is chief economist at moody's analytics big chunk of that tax cut for high income households with just wanted to peoples savings accounts and this saving is happening at a time of unprecedented economic expansion so it seems the fruits of that expansion are really getting to a lot of lower income households and while saving is generally encouraged if it outstrips investment over the medium or long haul it could backfire get the ecards and teaches economics at Brown University investment which is going to be mostly the same as savings is not really taking up much better so have given rise to worries about book people of termina sectors technician he's as conventional wisdom is that the government can step in and stands to help stimulate the economy and this could happen via the stimulus plan or infrastructure spending but that of course also has a hefty price tag I'm a dealer for market place look the economy is complicated just witnessed that savings rate story and it just it for us right and we know that sometimes try the we might to help you understand it we throw business and economics at your pretty fast so today the new series in which we slow way down and go back to basics were calling it this is not my idea we're calling it hi explains. hi hi hi hi you recently ask what's going on with this economy so how did these two concepts work together. our.
"two effects" Discussed on KCRW
"Monday Tuesday the twenty third of September that is always to have you along everybody we begin today with a little bit of well that's good. I think according to the people who keep track of this stuff which in this case is the US department of commerce Americans are saving more so far this year we are saving more than we have since before the recession which is good I thank because something's going on here usually when an economy is growing as the American economy is people sable less not more but here we are in the longest economic expansion we've ever had. or save it market places in dealer has this look at what's going on if people are saving money they're doing it for two main reasons retirement and if they're uncertain about their economic future what we're really seeing is more the second effect happening that's against matters he's an economist at the Wharton school of business people face a lot of uncertainty you know about the future and keep our increase their precautionary saving he says were also only ten years removed from the Great Recession so people could still be scarred from that the propensity to save breaks down by income level higher income households in to save more those people also benefited more from the tax cuts and jobs act of twenty seventeen mark Zandi is chief economist at moody's analytics big chunk of that tax cut for high income households with just wanted to peoples savings accounts and this saving is happening at a time of unprecedented economic expansion so it seems the fruits of that expansion are really getting to a lot of lower income households and while saving is generally encouraged if it outstrips investment over the medium or long haul it could backfire Getty ecards and teaches economics at Brown University investment which is going to be mostly the same as savings is not really picking up much better so have given rise to worries about what people of termina sectors technician he says conventional wisdom is that the government can step in and stands to help stimulate the economy now this could happen via the stimulus plan or infrastructure spending but that of course also has a hefty price tag I mean dealer for market place look the economy is complicated just witnessed that savings rates story and it just it for us right and we know that sometimes tried the we might to help you understand it we throw business and economics at your pretty fast so today the new series in which we slow way down and go back to basics were calling it this is not my idea we're calling it hi explains. hi.
"two effects" Discussed on Newsradio 700 WLW
"Say. That sounds he government faith. Everyone is the all in order to be certified at the senior under fifty all need to learn what they do is end the crisis. These treatments would be widely available all over America because people want to be dependent. Okay. They wanted to few high. He wanted to cure faith that they made any state. But once they become defendant, suffering, they have to fulfill peeling every day, and they didn't want to be like that in the declined by diet, he not because who they are. But because he's had the same medical condition that's communicate psychological, and social problems. We charge not will so, but the second effect of the untreated, Bryant illness, still one people understand that for each scribes as the only. Use of beaten than billions of dollars because you can beat him in the wrong direction and you have no without looking must change direction. And you log their medicine like using all the illness makes makes entire sense to me, Dr Andrew Weissmann. I know you're, you're busy. You're in Lithuania now practicing. And I hope that those at least at the Ohio State house at the level of the governor's office in the honorable, Mike dewine. Here's this and says this is what we need. We need to cut through the BS, and we need to get this kind of treatment here, not just in the United States. But specifically in Ohio, I'm sure we'll chat again taking time out Dr and joining us here in the United States, you, welcome. God bless you. Take. You isn't that incredible. And listen to that story. It almost sounds too good to be to thirty six hours. He has twenty four thousand patients over the last thirty years. No fatalities. It works in tonight. They'll be the debate over healthcare in America. Here's a solution right here. Why don't we cut out the middleman and the BS and go right to the people who know like Weisman? Slowly, seven hundred eleven hundred WLIW check news in a second. It's one of those things that sounds too good to be true. Put certainly deserves further investigation. The cure for opiate addiction, I said to.
"two effects" Discussed on The Talk Show
"And then, of course, there was the two FX, which is the one, of course I wanted. But it was I think the Maktoum FX retailed in one thousand nine hundred ninety and ninety one for around like fifteen sixteen thousand dollars in there in one thousand nine hundred dollars and it was not, not for regular people. There was one kid at Drexel who had one he had a two x. He was obviously came from a family with money and remember the games specter. Yeah. Yeah. Sure. Tank game. Yeah it was a three d tank game. And everybody who knew anything new that you would put it in outline. View instead of fully rasta rising, the panels because it would you'd get higher frame rate in a better network performance. But the kid who had the two facts, I, forget his name, but he was also a spectre. He cheated specter. He like he used resin to you. To hack your specs in it was like, I think you had like a limit of. You would like points to assign to like speed shields and firepower. And so you'd have to balance it and he like it was it was very clear that he had hacked his version. He was a cheater. I mean, why would you cheat you already have two effects? Why would you put a back already winning? But I wanted to fax I would've loved to, if I had, if money were no object at as a freshman in college, which is obviously an oxymoron. I would have had one, right? I wanted to it would have run specter better. It would have run everything better at this point in my life. I have no need for the current MAC pro. I mean it's just overkill for me. I mean I'm still on a twenty fourteen. I'm back five K, which I never get slow for me. If I got a new machine I probably get the I MAC pro just because I love. I love the design. I can't see why cow I could possibly justify anything more than an I MAC pro. Yeah, I have the pro and I only justify it because I have all of these podcasts audio files that I process using these Clinton like high end plug ins where it takes. You know, I'm denouncing four hours of audio for five people, and it was like, oh, that's actually enough reason for me to get nine MAC pro. But even then I'm pushing it, and certainly the, the, the MAC pro there's, there's no reason..
"two effects" Discussed on Bloomberg Radio New York
"Peter Barnes with June Grosso, still to come campaign contribution, limits are hiked just in time for the twenty twenty elections. But first a check on the markets. Here's Bloomberg's Greg Jarrett. Greg well, June. It's red we're headed into the worst week for the SNP since December after Australia's central Bank joined European British officials in Tampa down economic forecasts at the same time the prospects for an extension of the US trade detente with China continued to fade David Belan, Citi, private Bank, chief investment officer tells Bloomberg we should really be looking beyond the news. What's really going on with China is two things? One is the trade with the US, but many of the companies that produce goods in China have other plants in Vietnam in Cambodia in Thailand, Indonesia, and the second effect on China is that the manufacturers are going to move their operations, and they've planned to their operations outside of China this to sort of forces that are that are aligning against against China. We check the markets every fifteen minutes rep thirty. On Bloomberg radio s and p five hundred down six tenths percent down sixteen thousand eight tenths of a percent down two hundred and has Dax down six tenths of a percent down. Forty-one the ten year is up seven thirty seconds. The yield two point six three percents. West Texas intermediate crude oil is little changed at fifty to sixty seven a barrel. Comex gold is up three tenths of a percent at thirteen eighteen sixty an ounce. The Ballard one of seven Seventy-three the euro as thirteen thirty the British pound develop twenty nine thirty to be a 'electronic arts surged to its biggest gain since two thousand seventeen after the video game maker said its latest release track. The ten million users in seventy two hours APEC legends. Apex? Legends is the latest previously battle royale game from the the positive commentary music traction garnered online has outpaced the early success of epic games for the smash hit head publisher scrambling to catch up right now as up to a point seven percent. That's a Bloomberg business flash politics policy, power and law continues. All right. Thank you. Greg. The Federal Election Commission announced the increased candidate contribution limits this week along with hikes and contribution limits for political parties for the twenty one thousand nine hundred twenty election cycle from our on all of this. We're joined now by Ken Doyle, Bloomberg government, senior editor for money and politics is in our Bloomberg ninety nine one studios, and Ken, what are the numbers the latest contribution, the basic individual contribution limit for a candidate than that a person contributor can give to a candidate has been increased by one hundred dollars to two thousand eight hundred per election. So that's for the primary, and if if the candidate wins, the primary also twenty eight hundred for the general, this is something that's done by the Federal Election Commission, every two years at the beginning of an election cycle. They review the effects of inflation and adjust contribution limits to index for. To account for inflation. The law came Feingold law that was passed almost a couple of decades ago now set a two thousand dollar contribution limit and said that going forward it would be index for inflation. So we're now at twenty eight hundred for the basic individual limit. They also increase some of the limits for political party committees. And I think the bottom line is that. We will continue to see increases in overall campaign spending as we've been seeing for a long time. And and part of the reason is that the contribution limits now go up with the cost of living. Will this have any impact on the parties are on individual candidates, or is it just such a little bump? But that it won't. Yeah. I think the the main thing is the overall impact that it will. Continue to increase the overall cost of campaigns. We had we've just coming off of a twenty two thousand eighteen midterms that costs well over five billion that was, you know, more than a third of what the previous record spending in midterms. So we're seeing it's another factor in ratcheting up the overall cost going into the twenty twenty election, which is going to be another massively expensive because we'll have a presidential race and congressional races. We already have several democratic candidates that are out there raising money. Currently we have President Trump who who opened his campaign committee for business that the day. He was the day after he was inaugurated and has already raised one hundred million even before the presidential cycle began. So I think this is just another sign of the fact that it now takes billions and billions of dollars to run campaigns and for. People to get elected to to the White House, and the congress also had a story on the terminal this week about Norman Lear and his nonprofit group. Go ahead. Oh, yeah. Interesting stuff. This is disclosure, right? This is so in addition to the candidate contribution limits that were just talking about their their unlimited. Spending and contributions to super PACS and other outside campaign spending groups that go into campaigns. They usually look for the key races that will decide control of congress, for example or get involved in the presidential races. Sometimes and they are able to spend unlimited amounts of super PACS report what they do. But then there are these other groups usually designated five, oh one C four their for their tax exempt status. And they often almost universally claim not to be required to disclose their donors. This includes people people for the American way, which is this Norman Lear found a group know group that's been around for about twenty years. And the interesting thing here is that there's been legal action over the last couple of years, which has broadened disclosure requirements, at least on paper, at least, according to the courts, they saying that the law really does require these groups to disclose more about what they're doing than they have been and in in the kind of real world of politics. They haven't paid too much attention to it until now and then with these most recent F E C reports file by. Norman Lear group and some others. We're actually seeing them start to disclose some of their donors the donors who gave some money after these court decisions last fall. And that that's interesting. It's interesting in contrast to some of the other groups that continue to not disclose the the largest one in the last election was a group called majority forward with spent more than forty million dollars to help elect Senate Democratic candidates, and it's still claimed that it has never received a dime from anybody to try and influence elections. So that is something that kind of strange the credibility of of these groups and. I think what it means is that they're under more pressure. And they're feeling more pressure to reveal what they're doing. And let people know who's actually trying to influence their votes aren't Ken Doyle, Bloomberg government, senior editor for money and politics. Thank you for your reporting today. One a hit this story hitting this headline hitting the Bloomberg terminal now on the basis of. Story. Federal prosecutors are reviewing the national enquirers handling of its story about Jeff Bezos extramarital affair to determine if the company violated an earlier cooperate cooperation deal with prosecutors that according to people familiar with the matter we'll be talking more about this story later in the show. But let's I get go back to Bob moon for a check.
Metro Exodus Leaving Steam For Epic Games Store
"The previous metro games will also be added to the retailer later and twenty nineteen. So we have a couple updates the first update a later press release we receive from deep silver explained that the game will return to steam a year actor release metro exodus will return to steam on the other storefronts after February fourteenth twenty twenty update number two effect on the move FAQ on the move from steam. In fact, this is Don, right? Epic says that people who were physical dishes eventually. Broken. Stating clue you feed you kitchen game. But the key allowing you to play just us whether the key will be for Seymour epic game store team silver clarify on Twitter today that I'll be
"two effects" Discussed on Bloomberg Radio New York
"The last press conference Jordan because it was less dodge expected I think the digital portables in order to limit the market turmoil and to avoid mistakes made the during the two thousand and thirteen tape attention, and they think. A two weeks already priced in the market and also in the sovereign a third day. Of course, we affect sovereign spread in the region. But I think there is there are two factors that we caution does affect the first of all again enclosure on the JP Morgan market index and the second is that starkly. There is a strong local support for sovereign issue in the region. Therefore, I think the two effects will mitigate each other. And in terms of our spread spread relative to treasuries foot for twenty nine thousand nine how do you look at that? By the way, your base case is two more hikes from the US. It might be escape is the central Bank is collision around. The also what the sentiment is my personal view is too hikes. Probably tree. If you look at the last week number of non-farm payroll that was a confirming that the US economy is solely footing. That's why the treasury rallied over ten point two two point six six. So again, I think there is a potential of surprising the upside for the market the market is being overly negative in the last few months over the China and the US. Crisis. And I think there is definitely a potential for a surprise zero. Okay. It was good to get somebody with a contrarian view. Somebody's actually gonna get which gets us off zero zero actually. No. But you don't mock hastily made the point at UBS New York Times over the weekend. He said if they hike in March, it's going to be a mess. So say where the mass comes by the way, the spreads GCC white night. Then spreads will widen night. If your case comes to bear. Well, if Mike. Yes. Okay. We'll bring you back, and we'll benchmark those are better. Thank you, very much bigger than is the executive director and head of fixed income for the Meana region at exotics going contrary. We'd like it on daybreak up next device property slump. I.
Recovering from brain damage
"We've talked about the skin the liver and the heart. But what about when the brain gets damaged Kavita bossy is a strict survivor in his shed her story of life after strike with us, then two thousand fifteen when I was thirty eight years old. I was taken into an e with a life threatening illness severity night brain hemorrhage prior to this leading a happy healthy lifestyle. I just didn't expect something like this would happen to me the night it happened. I. Had come home from work a little earlier with a headache and watch some TV and I woke up then approximately eleven PM screaming with huge pain as if a sledgehammer had hit the back of my school, and I had a seizure then and collapsed. I was treated at sofa trial hospital Manchester with various oppressions over the next few weeks. My life now is updating to this new me, I have trouble with short term memory loss. Severe headaches difficulties with certain noises Costra phobic hiring Zayed's. An also personality shift are now have very straightforward black and white thinking, and this is difficult for people who know me to stand career Bessie who recently published a book on her experiences who room twenty three surviving a brain hemorrhage. Having a stroke can have a devastating effect on your life and recovery especially difficult because the damaged areas of the brain. Paul permanently dead. All they I spoke to neurologist Tom com. Icu of the university of California, Los Angeles about research. He's pursuing to re-grow brain tissue after a stroke key cell types, in the brain the neurons that send the signals really are fixed after a certain age in humans somewhere between two and five years old. We don't get any more brain cells. And so we can't as a result regenerate, new brain cells themselves in large quantities. And so when there is a area of dead brain, you can't re-grow into that area. Normally from the brain next to it because the brain cells themselves, the neurons are what we call in the scientific field post, my Totic, they can't divide inform substantial quantities of new cells. Would you call the scarring than this? These that sells. Yes, what happens is the the area dies. And then some of these cells called glee proliferate and wall off the area of damage. And they participate along with other sales in the formation of scar. That helps contain the damage, but may also have a second effect of limiting some of the repair and recovery. How would that reflect in sort of the treatments you can give people currently as many will know, the there are no medical therapies for recovery in stroke. The treatment is activity based physical therapy, occupational therapy or speech therapy. These are very limited in their efficacy. And so there are no therapies that stimulate recovery stroke, and what we've been focusing on is the science of what the sales do after stroke, and how we might develop medical therapies that enhance that recovery. Right. Yeah. How how is your lab investigating us? We're very interested in what the brain starts to do. And then gets and then get stock and doesn't progress fully. So we've been investigating the molecules that stimulate brain cells to form new connections or the. Molecules that stimulate blood vessels to grow and branch out in the tissue, adjacent to stroke. And our reasoning is if we can understand those molecules, we might understand why they don't produce a more full recovery, and then develop drugs that boost those molecular systems and boost recovery how you testing out the properties the