29 Burst results for "Symptomatic Disease"
"symptomatic disease" Discussed on WTOP
"To talk this over. Well, we have to give a nice nod to that original vaccines. When the original variant, because it protected us for a few years and did a remarkably well. But the virus has changed and what we're seeing now is the Pfizer and Moderna bivalent booster, both of them have one are more effective in terms of neutralizing the current variant of the virus. And they do amazingly well. A new CDC study showed that if you're under 60, it almost reduces hospitalization 50%. I mean, symptomatic disease, 50%, and a hospitalization over 90%. So it's pretty dramatic in terms of its protection. And so we're transitioning to the new one. And I think important thing is, what they said is that every fall every year, the average person should get this booster once a year. So instead of all the confusion about when and who should get it, this is a much clearer message. What about the flu shot? Would you maybe pair it with your yearly COVID shot and kind of get it all done at once? Yeah, I think that's what's the normalization is that we've been normalized. Half the country gets a flu shot every year, whereas only 16% has gotten this bivalent booster. So if we do it, we do them together in the fall. We get both of them. We're both going to be protected going forward for flu. And keep the immunity up for COVID-19. If you're elderly or have other conditions, it may be twice a year, but for the average person it's going to be once a year. Would you say right now we are still losing far too many people to COVID in our country. Yeah. It's very difficult in our country to get accurate data. The numbers are three, 400 people a day are dying of COVID. But when you look at that, many of them are dying with COVID rather than from COVID. And it's very hard to distinguish exactly how many. There clearly are many dying and everyone that dies is too many, because most of those are protected with the vaccine. It should be protected by the vaccine and PEX lovit. So it is frustrating that people are still suffering from this virus. When we have the vaccine readily available, we have a drug that if you test positive in the patients who are high risk can prevent that hospitalization. Back to the flu shot comparison, we know that every year the specialists take a look at what they think flu might be and Taylor, the vaccine to that. How about with COVID? How would it work with that yearly shot? Same thing. We're going to have that crystal ball, and we're going to start to see the virus is changing. So let's make the booster a little bit different so that we can have a broad enough immune response to really contain what the virus is that year. Over a million years of evolution, the human genome changed 1%. This virus can change 1% in a day. And so the idea that the virus can change is real. And we really have to respond with science when it does. Final thought here about what the advisory panel is saying and I guess maybe more broadly our national approach to COVID this year. I mean, what they're saying is that we've been very poorly compliant with the current boosters and that there's a lot of myths and disinformation out there. So having a cogent, simple policy, just like the flu shot is the way to go. And when he won national voice, we need one national idea. And this is going to be it. Every fall we're going to get a booster to keep immunity up because most importantly, we have to block hospitalization and many people to block you from getting sick at all, not all, but it will block hospitalization is serious illness, and that's the key. Should be as news medical contributor, doctor David
"symptomatic disease" Discussed on Squawk Pod
"The godly after the cdc recommended booster shots for some americans. Confusion still remains regarding eligibilty and enroll out of a third vet pfizer vaccine. Join us dr scott gottlieb. Former fda commissioner cnbc contributory also serves on the boards of alumina and pfizer his new book uncontrolled spread why cova nineteen crisis. And we can feet. The next pandemic is out now. So many nuances to to the vaccine. Scott i you know frustrating because the panacea we had hoped for. It's not even close Breakthroughs in and viral loads of double vaccinated people in all these things. What about therapeutic that that we could get in the form of a pill like we used with other viruses. It's definitely possible to do pfizer's working on one. Burke and ridgeback are close to disrupting the replication of the virus which turns it into not even a serious flu. Almost plus the viral load never gets high enough to cause those immune immune system problems that we get to kill so many people with cohen. That's the only way we're ever getting out from underneath this. A booster every year and another one in breakthrough cases. Vaccines aren't gonna aren't going to be the answer to get us back to normal. Well i wouldn't accept that vaccines aren't going to be the answer. We don't know what the long term immunity is going to be. Especially after you boost the population. This might be three dose regimen. It might be an annualized vaccine like we take for flu and the vaccines are holding up. Pretty well to fulfill original premise. That they're preventing hospitalization severe disease even symptomatic disease in most cases With respect to that therapeutic There's news out today from pfizer. The company i'm on the board of about advancing their drug into clinical trials to prevent infection in Close contacts you're right. The merck drug is advanced as well. Roche has a drug that's also an advanced development a little further behind but looks very promising and in as a whole host of drugs that are in earlier development that were engineered specifically to target. This sars covy to virus. I do believe we're going to have an antiviral to your point. This isn't a hard virus to drug in terms of how it replicates. But i'll just offer that it's going to become increasingly difficult to run. These clinical trials in a population. We have a lot of people who've been vaccinated and a lot of people who've been infected so you know running trial to prevent progression of symptomatic disease or to prevent the onset of disease and close contacts is difficult to find treatment naive patients or virus naive patients in the united states right. Now that's a good problem to have Obviously it's got that you can't find people problems have if the reason why you can't find people 'cause they're vaccinated right It's not a good problem if it's they're infected. So aren't you for what i can't understand. It is the angst and they and they you know seeing mass everywhere again. What we thought was going to be different was three four five it in january. So what looked like. The end is nowhere near the end. Because of these breakthrough cases whether they're really really common whether they whether you're a symptomatic doesn't seem to matter anymore. Even if you're a symptomatic with the breakthrough case they're still a concern that you're gonna pass it to someone who's vaccinated and then they're going to be a symptomatic and it's going to keep getting passed until you get to someone who's either vulnerable or who's unvaccinated and it's just like this vicious circle that it's very frustrating and everybody's out look at i mean maybe there outside maybe not people inside. There's people in in stadiums there are people everywhere and you get a dirty look if you don't if you're not wearing a mask even if you're double maxed well let me just challenge for minute. First of all you're right. Everyone's out i mean. Society is functioning fairly normally. I'm not going to say it's completely normal right now but prevalence is still very high. We're still recording. Two thousand deaths a day a lot of hospitalizations on this delta wave is still sweeping across the country. So i think that's impacting behavioral psychology. And i think it's going to take a longer time for psychology to really evolve where we come to accept. Corona virus is just a fact of life and that there's going to be infections but that's going to be a point when prevalence really starts to decline and we start to see fewer hospitalizations fewer deaths. We're still really in in the throes of this. And then finally i think the reason why a lot of people are overestimate the risk of corona virus or still concerned about even if they're vaccinated know that they're not gonna get very sick but they might get a mild or eastern domestic infections because the kids are still vulnerable. I think once we're able to vaccinate children. Adults are able to vaccinate their kids. The anxiety about getting a breakthrough infection knowing that you probably not going to get very sick your odds getting very sick with very low if you're vaccinated but you could bring it back into the house. I think that's going to start to resolve so you know. This is going to be a slow evolution. You're right we've just spent a year year and a half trying to prevent every single infection and we're going to evolve to a place where this is an endemic virus and becomes a way of life where fact of life if you will It's going to be an evolution. It's not gonna happen overnight and they don't think the vaccines are going to be what drivers out of this. It's going to be when we come back. The children when prevalence declines when hospitalizations and deaths start to decline and they will they will on back into this delta wave. Scott could we talk about the booster for a second. This is the third booster available by pfizer. Not yet the case in but derna in terms of the ability to get infected one of the things. We don't know from these studies. We talk about sort of the nine ten times antibodies. But we don't know what that means in practice if the original second second shot guy you to. Let's say a ninety three percent rate now that was pre delta. What do you. What do you think the the third booster gets you too. Because part of it is people are trying to avoid hostels. -ation death but i do think there's a lot of folks including myself who would very much like to avoid infection and it seems like at least for several months after the shot or the first first vaccine or maybe the third vaccine that it there is at level of which there's almost an inauguration but maybe not yeah so good question in the public health community the premise that these vaccines are going to be used to prevent any infection at all That's where people start to get uncomfortable because they feel the premise of these vaccines that they should be used to prevent severe disease symptomatic disease hospitalization. That was the original of the vaccines and in order to prevent any infection at all you might need to continue to reboost to maintain high circling antibody levels. Now the data out of israel directly. Answer your question. And it's only one month of data that we're really looking at this point. Some some cases go out a little further than that does suggest that the immune protection at the third shot offers restores the protection that you had after the second shot. So if you're the second shot forty ninety five percent protection against any infection at all that does appear to be what you're seeing after this third dose. Now it's only short-term data. We don't know how durable the high levels of circulating antibodies are going to be an protection against infection. So it's open question right now. I mean we're going to have to continue to follow these patients but that premise that these vaccines should be used to prevent any infection at all. that's public health officials. And that's where the advisor committees got uncomfortable. Scott then then the second question and this goes to where i think joe was headed. Which is if you're vaccinated. And you've got a breakthrough infection and you give it to another vaccinated individual who therefore gets a breakthrough infection. What do you think the demonstrable dangerous in that in that context because because joe positive they were going to be dramatic and ancient dramatic. I know people who are eysenck dramatic and then.
World News Tonight with David Muir
"symptomatic disease" Discussed on World News Tonight with David Muir
"Have several developing stories as we come on a breaking headline at this hour involving the search for that missing woman with the coroner has now revealed but we begin tonight with news for the millions of americans who got the johnson and johnson one shot vaccine today johnson and johnson now revealing a second dose of their vaccine two months after the first dramatically increased protection against symptomatic disease. They say in fact ninety four percent protection after that second shot they say from moderate and severe covert johnson and johnson also reported that when a second shot was given months after the first shot antibody levels increased as much as twelve. Fold over the initial dose tonight. Also news on pfizer. The potential booster for millions sixty five and older and high risk americans. Tomorrow the cdc is now set to me. We could have a decision by late week. And this all comes as ten states. Now report a record number of hospitalizations in alabama for one reporting more deaths in twenty twenty then births for the first time in history. Abc's eva pilgrim leading us off tonight. Promising news for the fourteen million. Americans who got the johnson and johnson one shot the company reports that new data shows a second shot significantly increases protection. The single shot is still showing incredible protection. Immunity is not waning but that additional shot could help giving a second shot two months after the first boosted protection against symptomatic disease to ninety four percent. Almost identical to the peak protection seen in pfizer and madonna. And that second. J. j. shot offered one hundred percent protection against severe disease. Regulators will also review data showing johnson and johnson boost given six months after the first dose produced even higher antibody levels as much as twelve times the initial level. You have a growing body of evidence. That second child is going to be important now. It's going to be up to the fda to figure out when and how that happens. The johnson and johnson news coming on the eve of an fda decision and critical. Cdc meeting where they will decide the fate of pfizer boosters for millions of americans including people over sixty five and those at high risk from health conditions or jobs on the front lines and new hope for parents. To twenty-eight million children between the ages of five and eleven could be eligible for the pfizer vaccine as early as halloween. I would imagine we're talking at a matter of weeks possibly by the end of the month the beginning of next month because i know the fda really wants to do correctly but they want to do it quickly it comes as the number of americans in hospitals is starting to dip but ten states are still reporting a record number of hospitalizations and six states. Have ten percent or less of their icu. Beds available alabama reporting more deaths in twenty twenty then births for the first time in. its history. We are seeing a decrease in the number of patients that are in the hospital but unfortunately it's not because all of them are getting better and going home to their families. These patients are dying in idaho. Former nurse natalie. Rise in her mother did not give vaccinated and both wound up hospitalized with covert. But natalie didn't survive. Her brother says the forty six year old mother was influenced by misinformation about the vaccine. Natalie i believe fell into the negative social media but at the end of the day We have all these doctors and professionals pleading with us basically begging us to get this vaccination and the people who are telling us not to get it. Didn't pass high school science natalie's brother now taking care of her ten year old twins with special needs. And even pilgrim back with us again tonight. Eva in addition to this new data on the johnson and johnson booster shot. Dr faucher also suggested that we could see boosters from pfizer johnson and johnson and maderno all in the coming weeks. That's right david. The pfizer booster shot could be green lighted by the end of the week. Dr found she says the decision. On madonna and johnson and johnson. Clint com in two to three weeks. David eva pilgrim leading us off tonight. Eva thank you. We're going to turn now to the other developing story as we're on the air tonight. The news coming in and the disappearance of gabby petito the corner now out with their finding the autopsy confirming the body found in wyoming is the twenty two year old. Who went missing in florida tonight. Police have now resumed the search for her missing boyfriend. While five hundred miles away authorities are studying. This image captured a wildlife trail camera. The sheriff not ruling out that it could be brian laundry. The person of interest. Abc's trevor all in florida tonight. The fbi confirming a body found in wyoming's grand tetons is gabby petito the cause of death still pending final autopsy results but the coroner finding this is a homicide across of riverbed stones now marking the site. Where gabby was found today in florida. Investigators.
The Highwire with Del Bigtree
"symptomatic disease" Discussed on The Highwire with Del Bigtree
"You will hear in england when it comes to their passport or whatever. When they're discussing in europe about passports they least include natural immunity as one of the things that exempts you out of our the vaccinated. You have to have natural immunity or you have to test negative. You'll see that all over the world but for some reason here in america we're like erasing the science that we know. But here's one of the big questions we've been grappling with With our science team all over the world what happens to those people who naturally affected and then they get the vaccine. You know do. Does the vaccine then changed the immunity that they already have. Is it possible that it could be reinfected. Does it wane because we know that. The natural immunity is lasting forever and tony. She said well the vaccine just makes it even more powerful. Well that's been our question. What studies have shown that. There's been no studies on that but there's actually a study. We saw this week. That i think might be giving us a glimpse at something else now. This study was trying to prove that the vaccine works just as good whether you had previous infection or not but it actually reveals something. I don't think they intended comparing sars koby to natural immunity vaccine induced immunity reinspections versus breakthrough infections. Now look at this. The increased risk was significant. Precip dramatic diseases. Well when allowing the infection to occur at any before vaccination evidence of winning that was demonstrated through though here you go those sars. Kobe too naive vaccines. These are people that didn't have pre infection. Had a five point nine six almost six times. The increased risk or breakthrough infections and seven fold increased risk for symptomatic disease. Sars kobe too naive. Vaccines were also. Add a greater risk for cove in nineteen related hospitalizations compared to those who were previously infected this study demonstrates that natural immunity confers longer-lasting stronger protection against infection symptomatic disease and hospitalization caused by the delta variant stars company to compared to the vaccine to does vaccine induced immunity. That's actually a slide. I wanted to show you earlier. That was showing That natural immunity is better but can we get the slides that talked about previously vaccinated. Here we go. Significant is what i wanna talk about. Significant reduction in humour immunity among healthcare workers in nursing home residents. Now remember they were just trying to show that whether you had the virus before or or you know getting the vaccine or not. It seemed to have the same reaction. That's what they were trying to prove but remember. Our question is what happens to your long lived. Potentially life long natural immunity if you get the vaccine. That's what i think is reveal. Let's take a look at this. We report on immoral immune from two weeks to six months. Post vaccination in one hundred twenty new hampshire residents and ninety two ambulatory healthcare worker controls with and without free. Vaccinations stars koby to infection anti spike anti cd neutralization levels dropped more than eighty five eighty four percent over six months time in all groups irrespective of prior so's sars koby to infection at six months. Post vaccine seventy percent of the infection naive nhl residents had neutralization titus at or below the lower limit of detection compared to sixteen percent at two weeks after full vaccination seventy percent drop. I mean look at that. And they're saying it happened to both those that were previously infected or not so here. We have studies now known is doing the study. That's what we want to look at but we look at all the studies of natural immunity. We see that it's robust eight months and continuing on yet here. They're showing in six to eight months whether you had the infection or not. This vaccine is dropping your antibodies. I think we're now starting to see that. The vaccine is wiping away the immunity that's achieved through previous infection so people that are out there that are previously infected. You'd be nuts to get this vaccine right now. And it's incredible that tony pouty isn't racing to the microphones and cameras and say whoa stop. We've made a critical error. We're going to erase your immunity if you get the vaccine after you've been infected. He's not going to do that because they're trying to change the science as we know it they want you to believe that the only way to have immunity in this world is to be back in world there is no such thing as natural immunity and that's really unfortunate for us because it is the only thing that is going to get us to hurt immunity in this world. It is the only thing that's going to get us through this pandemic and i don't care how many times dot com patchy explains why cope in nineteen vaccines work much better than natural immunity to protect you from the corona virus. This science says absolutely the opposite so there it is. He ate his words. Cnn he should be gobbling paragraphs and paragraphs and pages in books of bullcrap. Because he's lying to you and you need to know the truth if you like that clip and be sure to check out our live broadcast of the high wire every thursday morning at eleven. Am pacific time. You can watch it on. I tunes end twitter we'll see..
The Highwire with Del Bigtree
"symptomatic disease" Discussed on The Highwire with Del Bigtree
"B. cells. Nt cells specific for source code to up to two hundred and fifty days. Now look at this next set intense. The kinetics of these responses provide an early indication for a favourable course ahead to achieve long lived immunity two hundred fifty days. We already know. Why is it limited two days. Because that's how long the virus was around so that they can study everyone that got infected. Everybody has been infected is still totally protected. Eight months later and they expected we'll go on when they look at the original sars corona virus. Those people that got it back and you know nine hundred ninety two thousand right in there. They still ramon. we're talking. Lifelong immunity is what we know to be the case for. Most sars corona viruses. This one doesn't appear to be any different so tony fallacy once again spinning pure bull here on television questioning the durability. But you know. I understand why. He's already got his face out there on the news saying the exact opposite and doubling tripling down multiple times. This is what that looks like. There's a question from jan in arizona. Who says will people who have already had the virus recommended to get the vaccine as well. The answer is yes because once you get infected with the virus it is in certain how long that protection for dave. Do you expect the vaccine will be like a flu vaccine. Meaning you'll have to get a new shot every year. I'm not so sure. It'll be every year but i would surprise the beginning life long immunity there it is. He believed the vaccine would give us a lifelong immunity. This it by that much. Tony come on. Didn't get anywhere near lifelong immunity. We're talking six weeks of immunity at best if you're looking to studies that are now coming in winning immunity. Meanwhile natural affection looks like it will go on for life except this statement that he makes there and this is one of the big conversations. It's where a lot of icons lawsuits around nation where we're fighting. We are fighting for natural immunity. Those that have been previously infected. They're trying to get into schools. They're trying to hold onto their jobs. We believe that is a hill to die on here in america We are not giving any exemptions to people previously infected. You will hear in england when it comes to their passport or whatever when discussing in europe about passports they least include natural immunity as one of the things that exempts you out of identity backs needed. You have to have natural immunity or you have to test negative. You'll see that all over the world but for some reason here in america we're like erasing the science that we know. But here's one of the big questions we've been grappling with with our science team all over the world what happens to those people who get naturally affected and then they get the vaccine you know do does. The vaccine then changed the immunity already have. Is it possible then. It could be reinfected. Does it wane because we know that. The natural immunity is lasting forever. And tony fouts. You said well the vaccine just makes it even more powerful. Well that's question what studies have shown that there's been no studies on that but there's actually a study. We saw this week. That i think might be giving us a glimpse something else now. This study was trying to prove that the vaccine works just as good whether you had a previous infection or not but it actually reveals something. I don't think they intended. Comparing co stars. Kobe to national tobacco induced immunity reinfection versus breakthrough infections. Now look at this. The increased risk was significant. Symptomatic diseases well. When allowing the infection to occur at any time before vaccination evidence of winning media was demonstrated through though here you go. Those sars. Kobe too naive. Vaccines these are people. That didn't have previous infection. Had a five point nine six almost six times. The increased risk or breakthrough infections and seven fold increased risk for symptomatic disease. Sars kobe to naive bax. These were also add a greater risk for cove in nineteen related hostile stations compared to those who were previously infected this study demonstrates that natural immunity confers long-lasting stronger protection against infection symptomatic disease and hospitalization caused by the delta variant stars company to compared to the vaccine to does vaccine induced immunity. That's actually a slide. I wanted to show you earlier. That was showing that naturally is better but can we get the slides that talked about previously vaccinated. Here we go significant. This is what i want to talk about. Significant reduction in humour immunity among healthcare workers nursing home residents. Now remember they. Were just trying to show that whether you had the virus before or or you know getting the vaccine or not. It seem to have the same reaction. That's what they were trying to prove. But remember our question is what happens to your long lived potentially ripe long natural immunity. If you get the vaccine is reveal you. Let's take a look at this. We report on immoral immune from two weeks to six months. Post vaccination in one hundred twenty new hampshire residents and ninety two aleatory healthcare worker controls with and without free vaccinations source koby to infection anti spike anti rb and neutralization levels dropped more than eighty five eighty four percent over six months time in all groups irrespective of prior. So's sars kobe. To infection. at six months post bac seen seventy percent of the infection naive nhl residents had neutralization titles at or below the lower limit of detection compared to sixteen percent at two weeks after full vaccination seventy percent drop. Look at that and they're saying it happened to both those that were previously infected or not so here. We have studies now. Known is doing the study. That's what we want to look at. But we look at all the studies of natural immunity. We see that it's robust at eight months and continuing on yet here. They're showing in six to eight months. Whether or not this vaccine is dropping your antibodies. I think we're now starting to see that. The back scene is wiping away. The immunity that's achieved through previous infection so people that are out there that are previously infected. You'd be nuts to get this vaccine right now. And it's incredible at tony. Pouty isn't racing to the microphones and cameras and say whoa stop. We've made a critical error. We're going to erase your immunity if you get the back seen after you've been infected. He's not going to do that because they're trying to change the science as we know it they want you to believe that the only way to have immunity in this world is to be back in world there is no such thing as natural immunity and that's really unfortunate for us because it is the only thing that is going to get us to hurt immunity in this world. It is the only thing that's going to get us through this pandemic and i don't care how many times dr patchy explains why cope in nineteen vaccines were much better than natural immunity to protect you from the corona virus. This science says absolutely the opposite so there it is. He ate his words. Cnn he should be gobbling paragraphs and paragraphs and pages in books that bullcrap. Because he's lying to you and you need to know the truth all right. Let's get on with the rest of this show huge show a lot to get through. We're going to break down this Biden's speech that happened last week. So why don't we bring in jeffrey jackson. The jackson report.
The Dan Bongino Show
"symptomatic disease" Discussed on The Dan Bongino Show
"Your kids at home and you will listen to us. It was body blows to freedom every time but the body blows to freedom warp the lockdown so and all this other stuff for the left that is is. They want to destroy america. They worked because people were scared. You've seen the polling already. Remember that poll guys remember the poets. The they ask democrats this belief allah. You've corona virus. Was it was like one of remember that joe they thought it was like fifty percent of the left doesn't know what because the media are idiots. It's a nonstop fear porn campaign. Here's what winds up happening when that had showing you there are real world consequences to illegitimate fear porn reporting the atlantic again. Why they're doing journalism all of a sudden. I've no idea. They did a study from march. Twenty twenty two early january twenty twenty one before vaccination was widespread and before delta arrive the proportion of patients with mild or a symptomatic disease was thirty six percent for mid january to the end of june twenty twenty one however that number rose to forty eight percent in other words the study suggests that roughly half of all hospitalized patients showing up on cova data dashboards in twenty twenty one may have been admitted to the hospital for another reason entirely only had a mild presentation of the disease. Folks i again. I don't i don't want to waste your time. I love that you hear. I never waste your time and self-praise sincerely stinks but proving again you're not wasting your time. I've told you this over and over and over again. That being hospitalized with corona virus does not mean you are hospitalized because of corona virus. They are different things folks. I have lymphoma if i wound up in the hospital god forbid for some complication related to lymphoma and test positive for corona virus. It doesn't mean. I'm mayor because of corona virus. It means you're air with corona virus but because the media working with their communist leftist masters these sycophantic media s kissing losers saw that a non stop fear porn campaign. Assist the left in diminishing your civil liberties they propagated the myth that this was the deadliest virus in the history of humankind hospitalizations through the roof..
The Last American Vagabond
"symptomatic disease" Discussed on The Last American Vagabond
"This is because you cannot make these viruses. Go away the natural history of all respiratory viruses is that they circulate all year long waiting for the immune system to get sick through the winter or become deranged as has happened recently with these vaccines and then they cause symptomatic disease because they cannot be filtered out and they have animal reservoirs and this is very important point. No one can make this virus. Go away the has managed to convince everybody that we can handle this. We did smallpox where we could make a virus. Go away. smallpox had no animal reservoirs. The only thing into effect with humans. That's why we're able to make that virus go away. That will not happen with this any more than it will. With influenza the common cold respiratory virus add no viral respiratory syndrome is or anything else that has animal reservoirs. So the reason. You can't do this because you're trying to do something which has already been tried and can't be done equally important. Is that vaccination changes none of this especially with this vaccine. I would hope this board would start asking itself before considers taking the advice of the cdc the nih and the state board of health. Why were doing things about this that we didn't do for the common cold influenza respiratory virus. And then ask yourself. Why is it vaccine. The supposedly so effective having a breakout in the middle of the summer when respiratory viral syndromes. Don't do that. And you understand that you need to know. The condition is called. Antibody mediated viral enhancement. That is a condition done when vaccines work wrong as they did. In every corona virus study done in animals on corona viruses after the sars outbreak and done in respiratory virus were vaccine used in a venerable individual. Done the wrong way which by cannot be done right for respiratory virus which has a very low pathogenicity rate causes the immune system actually fight the virus wrong and let the virus become worse than it would with native infection. And that is why. You're seeing an outbreak right now. In fact in that flash drive. You're going to have coming to you. In emails with six extra olbia studies showing that seventy five percent of people who had cove nineteen positive symptom cases in barnstable massachusetts. Outbreak were fully vaccinated. Therefore there is no reason for treating any person vaccinated any differently than any person unvaccinated. You should also know that no vaccine even the ones i support and would give to myself and my children ever stops infection in two thousand fourteen. There was outbreak of mumps in the national hockey league. The only people who came down the symptoms with people who are unvaccinated are unknown vaccine status. Boy that sounds like a great argument for vaccines but a question that you should ask yourself knowing that. Half of the people who came down with symptomatic disease had no contact with an unvaccinated or unknown vaccine status individual. Where did they get the disease. In the answer was from the vaccinated individuals no vaccine prevents you from getting infection..
World News Tonight with David Muir
"symptomatic disease" Discussed on World News Tonight with David Muir
"It was a stunning fall from grace. It concern you that a number of tests weren't working on thoroughness devices. Her story unbelievable. Her voice aunt mistake. I know that we made so many mistakes. This strange saga of elizabeth homes continues. I'm rebecca i've been reporting on the case of elizabeth homes for more than five years. And now that she's finally going to trial will be following the case and elizabeth every step of the way. she's a big risk fingered. I think she's hold a robot dockings. The dropout elizabeth homes on trial begins august. Thirty first wherever you get your podcasts. That is correct. This is not about the durability of a good response to keep it up these for people who almost certainly did not get an adequate response to properly protect them in the first place which is understandable because their immune system is compromised. And when you have a compromised immune system you're not gonna get the type of response that most of the normal general population so it really is to get them up to where they should have been in the first place. Dr which obviously people at home are going to wonder. Is everyone else next. You have said yourself that no vaccine lasts forever. So how soon could we see a potential booster shot for everyone here. Could we be getting guidance on this in a matter of weeks. Well i don't know if i can give you a timeframe david but the one thing i can tell you is that we are following in real time literally on a weekly and monthly basis but definitely a weekly basis where we look at the data from a number of cohorts of people who've been vaccinated and we follow what the efficacy of the vaccine is for example against symptomatic disease. And in general. You know it's going to start tapering down the rated which we're not clear right now but we're following it so closely and we're simultaneously preparing to be able to give people that additional dose which we refer to as a booster in the meantime it would seem these rallies though are ahead of us on this just today approving booster shots for fifty and older starting next week forty and older expected a short time after that. So so what are they seeing in the numbers that were not what they're seeing in their population. David is that when they go down over several months they do pretty well and then they have what looks like a pretty shop. Drop in the efficacy what what holds up. Well which is good news is that they still get good protection against severe disease leading to hospitalization and death but the protection against symptomatic infection and early infection has gone down considerably. It's interesting you point out what you think. They're seeing right now. Let me ask you about this new mayo clinic. Study just out tonight. It needs to be peer reviewed but it does look into whether these vaccines are wearing off over time here in the us and as you know it suggests that the pfizer vaccine after six months really begins to lose its punch less than fifty percent effective. After six months. I know more study is needed. But but does this concern you. Well it does. And that's why david we're watching very very carefully and putting all of the data together on multiple cohorts. We look at every study..
The Michael Berry Show
"symptomatic disease" Discussed on The Michael Berry Show
"It was on this day in seen eighty four the band. Who sings this song. Released their debut album a decent chance. You know the band and quite a few of their songs but don't recognize this song and this was the biggest song most airplay anyway off of that album. Nineteen eighty-four in the red hot chili peppers released. An album called red hot chili peppers in a collaboration. That by all accounts was A little difficult with producer. Andy gill the british rochman gang of four because the red hot chili peppers in nineteen eighty-four. Were not as big as you remember them later. They would release mother's milk in eighty nine and blood. Sugar sex magic ninety one asks when they hit it big and they would go on to be inducted in the rock and roll hall of fame as a matter of fact there is a doctor named dan. Stock who spoke to the mount vernon school board and his comments are getting a lot of attention. This is a longer clip than we would typically play on the show. But i think what this particular doctor. He's a. he has a family medicine. Practice in indiana. I think what he. I think you'll understand why this went viral. Give this a listen. Dan stock Five seven seven seven. Seven north records ville indiana Address your combat. Jeez hard to believe eighteen months into this and still having a problem. And i would suggest the reason we still have a problem. It's because we're doing things that are not useful. And gary sources of information from the state board of health and the cdc who actually don't bother to read science before they do this. I'm actually a functional medicine. Physician that means. I am specially trained in immunology and inflammation regulation and everything being recommended by the cdc state of health is actually contrary to all the rules of science. So things you should know about corona virus and all other respiratory viruses. They are spread by aerosol particles which are small enough to go through every masked by the way the literature that supports all of that is in a flash drive that we presented to you. It's been given to. The secretary is a matter of fact it quotes at least three studies stat sponsored by the nih to that exact fact even though the h have chosen to ignore the very science that they paid to have done That is why you keep struggling with this. Because you cannot make these viruses go away the natural history of all respiratory viruses is that they circulate all year long waiting for the immune system to get sick through the winter or become deranged as has happened recently with these vaccines and then they cause symptomatic disease because they cannot be filtered out and they have animal reservoirs and this is very important point. No one can make this virus. Go away the. Cdc has managed to convince everybody that we can handle this like. We did smallpox where we could make a virus. Go away. smallpox had no animal reservoirs. The only thing that learned to infect humans. That's why we're able to make that virus go away. That will not happen with this. Any more than it will with influenza the common cold respiratory virus add no viral respiratory syndromes or anything else that has animal reservoirs. So the reason. You can't do this because you're trying to do something which has already been tried and can't be done equally important. Is that vaccination changes none of this especially with this vaccine. I would hope this board would start asking itself before. It considers taking the advice of the cdc dna h and the state board of health. Why we're doing things about this that we didn't do for the common cold influenza or respiratory virus. And then ask yourself why is it. Vaccine that is supposedly so effective. Having a breakout in the middle of the summer when respiratory viral syndromes. Don't do that and to help you understand that you need to know. The condition is called. Antibody mediated viral enhancement. That is a condition done when vaccines work wrong as they did. In every corona virus study done in animals on corona viruses after the sars outbreak and done respiratory virus were vaccine used in a vulnerable individual. Done the wrong way which cannot be done right for respiratory virus which has a very low pathogenicity rate causes the immune system actually fight the virus wrong and let the virus become worse than it would with native infection. And that is why you're seeing outbreak right now. In fact in that flash drive. You're going to have coming to you. In an e mails with six extra studies showing that seventy five percent of people who had covert nineteen positive symptom cases in barnstable massachusetts. Outbreak were fully vaccinated. Therefore there is no reason for treating any person vaccinated any differently than any person unvaccinated. You should also know that no vaccine even the ones i support and would give to myself and my children ever stops infection and two thousand fourteen. There was outbreak of mumps in the national hockey league. The only people who came down the symptoms with the people who are unvaccinated are unknown vaccine status. Boy that sounds like a great argument for vaccines but of question. You should ask yourself knowing that. Half of the people who came down with symptomatic disease had no contact with an unvaccinated or unknown vaccine status individual. Where did they get. The disease in the answer was from the vaccinated individuals novak seen prevents you from getting infection. You get infected. you shed pathogen. This is especially true of viral respiratory pathogens. You just don't get symptomatic from it so you cannot stop. Spread cannot make these numbers that you've planned on get better by doing any of the things you're doing because that is the nature of viral respiratory pathogens. And you can't prevent with a vaccine because they don't do the very thing you're wanting them to do. And you will be chasing this the remainder of your life until you recognize that the center for disease control and the indiana state board of health are giving you very bad scientific guidance and instead read the articles that are gonna come in the email on this flash drive and listen to the people in this audience tonight who actually have recognized the advice. They are getting from the cdc in the nhl counterfactual. And that's why you're still fighting this with this vaccine that supposedly was going to make all of this go away but suddenly managed to make an outbreak of cove nineteen develop in the middle of the summer when vitamin d levels are at their highest by the way the other thing that we've necessarily any vaccine restriction to be considered if there were no other treatment available and i can tell you having treated over fifteen cove in nineteen patients that between active loading with vitamin d ivermectin zinc that there is not a single person who has come anywhere near the hospital and we already have studies that show that if you cheat at twenty five hydroxy vitamin d level greater than fifty five. Your risk of nineteen death will drop down to three at one quarter of the population average. The united states and they're active treatment trials included on that flash drive but the same is true. So if you were going to discriminate based upon vaccine you should also discriminate based upon twenty five by drugs vitamin d. level zinc taste tests response and probably previous infections are also studies like flash. Drive that show that people who have recovered from kovic nineteen infection actually get no benefit from vaccination at all no reduction in symptoms the reduction in hospitalization and suffer two to four times the rate of side effects if they are subsequently vaccinated therefore the policies that you are basically gone are totally counterfactual. I don't blame this board for that. Because i know you aren't scientists and you thought it was reasonable to listen to the nih and the indiana state board appel. But i would encourage that instead. You listen to the people out here in this audience and read. What's on that day to drive. And if anybody here on. This board has any questions about anything on that. I will happily come back and sit with you individually if you would like to explain the science behind and if you're worried about being sued by somebody because you don't follow the guidance of the cdc in the nih. I will tell you have a free pro bono expert testimony.
Exchanges at Goldman Sachs
"symptomatic disease" Discussed on Exchanges at Goldman Sachs
"Now one of the questions is maybe this has to do with the timeframe of vaccination as many people know israel was at the leading edge of the global vaccination campaign and so there could be some of waning effect of the vaccines over time. and so. that's one thing that again. The companies are studying. We're gathering more data on to fully understand that now as we shift to look at severe disease. Remember as i mentioned before this is a spectrum right so again here importantly i think the message is the vaccine. Efficacy against severe disease in hospitalization is still around ninety percent even with the delta variant and that comes from some data out of both israel and canada. So that's very encouraging and so bottom line is if you're double vaccinated have very good protection against delta especially against severe disease and hospitalization and that's obviously a big focus of the healthcare system because when we talked about these lockdowns in different measures that countries are taking it relates to really trying to preserve that healthcare system capacity. And so given the vaccine efficacy. Were seen here out of israel and canada very encouraging protection against severe disease. Let me just thought to that. Because obviously we have pfizer. We've moderna we have other vaccines around the world. Are there any very material differences between these vaccines. So i'd say bottom line it looks like the messenger. A vaccine so pfizer by on tech and madeira are somewhat better than the adenoviruses. Vaccines those from astrazeneca. Jay for symptomatic kovic nineteen so again that kinda symptomatic disease but all four these vaccines look to be very very good again. Severe disease hospitalization. So not as much of a difference there and remember that's the big focus of the healthcare system is ensuring that we're protected against severe disease and hospitalization so less differentiation among the vaccines on that front. We're hearing that the severity of illness for breakthrough infections so meaning vaccine to people getting the infections is actually lower. Is that true. What is the evidence. Say around that yet. Obviously another very important topic here in everyone's probably seen a lot of different headlines on this. So look you know. Vaccine breakthroughs are still generally rare. But unfortunately they do happen. Now the flip side of it is if you do have a breakthrough infection. The symptoms and duration of illness is likely much less severe than it would be if you aren't vaccinated and there's some data that's emerged on this front from earlier in the pandemic that suggests if you do have a breakthrough infection you still have about sixty percent..
The Last American Vagabond
"symptomatic disease" Discussed on The Last American Vagabond
"I mean it's just incredible where we are. As a matter of fact it quotes at least three studies so sponsored by the nih fact right and that's the best point and that's what i said in the beginning the nih are the ones that sponsored this research and then pointed these facts out and then because everything flipped on its ear fake news. All of a sudden we were wrong. And we've reevaluated. Based on nothing actually different. Yeah apparently so. Even though the cdc in the nhl chosen to ignore the very science that they paid to have done. That is why you keep struggling with this. Because you cannot make these viruses go away the natural history of all respiratory viruses is that they circulate all year long waiting for the immune system to get sick through the winter or become deranged as has happened recently with these vaccines and then they cause symptomatic disease. Now here's an interesting point as well remember. We just talked about the concept of the variant. And what's causing. We're gonna touch on that moment but so we're talking about the variant and the idea that it's being it's only popping up because the unvaccinated keep saying but what did we learn by looking at the scientific research. We learned the reality that it's actually the combination of these things that help us create right. So it's the it's the unvaccinated in conjunction with people who are vaccinated but not dying but allowing transmission so it basically means vaccine. That doesn't work so they're pumping this thing into people's bodies that's causing this thing to happen but in conjunction with both of these scenarios it pumps out dangerous things where it can. That's what the sign of research has shown so. Seems like there's two options there which really when you dig into. It's not accurate. One would be all everybody everywhere. All the time vaccinated which is impossible as we've known throughout the history throughout all the history of these administrations of injections or everybody is no-one vaccinated right so there's no vaccinate investing in the mix and so people deal with this. They recover some people get six and people can die which is always the way this world has worked and we'd take we give ample exit. We take precautions for the elderly and then without the injection people kit over it. They'd get antibodies and then it's done now. it's still there which is point. It's still circulating. But you're good doesn't bother you anymore. Sort of like when you got the chicken pox when you're a kid and never caught it.
"symptomatic disease" Discussed on Radio Boston
"You're more comfortable and not take any chances with current virus. No i would say no one important thing but with this east new With these new guidelines is that the game is changing prevacid. People here's nj chisholm you again. The vaccines clearly are not a force field. They're not armor that bills an impenetrable defense against infection and symptomatic disease is clearly possible. So i think it's a paradigm shift and just forces such reorient around new reality in the era of delta. Yeah i think you know before we were looking at these these recommendations Before we learn these things about delta and thinking if you're fully tax needed be in these endure dense gatherings and still feel pretty safe. That seems like it might not be true anymore. You know outdoors highly event highly ventilated areas. That still seems like it's okay but You know we know that these vaccines do keep you healthy out of the hospital. They help to keep you out of the hospital but for me. Personally when i'm thinking about this like why jump into a risky situation like a crowded bar. Now that we're lucky enough to have the data that we have now and i'm fully vaccinated but i don't want to be sick in achey and four su quarantine for two weeks or you know or anything else where nine know just a little bit more careful and and follow those recommendations of the. Cdc is giving now all right so angry. I'm going to ask you to sit tight. I will come back to you in a couple of minutes. But i'm gonna bring another voice in here. Jog preach shot. While is a lead investigator of the cove. Nineteen simulator which models the potential future of corona virus infection and death based on behavior changes is also a science. Excuse me a senior scientist at the mass general institute for technology assessment and an assistant professor at harvard medical school professor southwell. I think you'd like to be called jag welcomed radio. Boston thriving me jack. Thanks for being here. So i i actually kinda wanna start with the You have catbird seat. I'll never have have you ever modeled. Anything like covert nineteen before. Is it weird or different or is it just something like you've seen before only big thankless close. Un this is changing on weekly basis. The modeling is complex. What we are learning is changing. We have to been the models..
"symptomatic disease" Discussed on Radio Boston
"You're more comfortable and not take any chances with current virus. I i would say no one really important thing but with this east new These new guidelines is that the game is changing new people. So here's nj chisholm you again. The vaccines clearly are not a force field They're not armor that bills an impenetrable defense against infection and symptomatic disease is clearly possible. So i think it's a paradigm shift and just forces such reorient around the new reality in the era of delta. Yeah i think you know before we were looking at these these recommendations before we learn this these things about delta and thinking if you're fully tax needed now you can these indoor dense gatherings and still feel pretty safe. That seems like it might not be true anymore outdoors highly event highly ventilated areas. That still seems like it's okay but You know we know that these vaccines do keep you healthy out of the hospital. They help to keep the hospital but for me. Personally when i'm thinking about this like why jump into a risky situation like a crowded bar. Now that we're lucky enough to have the data that we have now and i'm fully vaccinated but i don't wanna be sick in achey and four su quarantine for two weeks or you know or anything else where nine just a little bit. More careful and follow those recommendations to the cdc is giving now all right. So i'm going to ask you to sit tight. I will come back to you in a couple minutes. But i'm gonna bring another voice in here. Jog pre chartwell is a lead investigator of the covy. Nineteen simulator which models the potential future of corona virus infection and death based on behavior changes is also a science. Excuse me a senior scientist at the mass general institute for technology assessment and an assistant professor at harvard medical school professor southwell. Well i think you like to be called jag. Welcomed radio boston. Thanks for having me jack. Thanks for being here. So i actually kind of want to start with the You have a catbird seat. I'll never have have you ever modeled. Anything like cova nineteen before. Is it weird or different or is it just something like you've seen before only big matt thank. Un this is changing on weekly basis. The modeling is complex. What we are learning is changing. We have to upgrade..
The Ben Shapiro Show
"symptomatic disease" Discussed on The Ben Shapiro Show
"Right that's a lot lower than the ninety percent against confirmed alpha infection but at sixty four percents still means that basically in sixty not basically sixty four out of one hundred cases where you have the visor to maxine you're going to avoid being affected with delta sixty four percent effective against symptomatic disease but again we don't care about symptomatic disease what we care about his hospitalization or death a hospitalization or death. Ninety three percents effective against delta compared with about ninety four percents effective against alpha so in other words these vaccines are extremely effective in preventing hospitalization death. Which last time. I checked is the main job of the vaccine. Now we get to the masking portion of what the cdc suggests there many problems with. What the cdc gesture in terms of masking so number one. They assume natural immunity is about five percent. Okay or about thirty five percent now. It's possible natural. Immunity is much higher. The many many more people have had this then the cdc is willing to contemplate in fact the they they created these models. Showing many people will likely be hospitalized in die or or the probability the increase in caseload. They saw natural immunity numbers. The big the big problem. Here is the model assumptions which they list here in the cdc report so they assume the vaccine effectiveness in preventing transmissibility is somewhere between seventy five and eighty five percent. Okay fair enough looking at the data. That's fair enough then. They assume that we have had fifty percent of infections reported in the united states time. This is wildly incorrect. There is no way that fifty percent of the infections in the united states have been reported ever at any time in the united states. It the reality is. The vast majority of infections already prevalent in the united states. Probably have not been reported. Scott gottlieb from fda commissioner says this is an utterly unreasonable assumption completely unreasonable. How many people out there who are vaccinated for example have had cold symptoms right. I've had a cold symptom. I've been tested. Because i've called symptoms and unvaccinated less five minutes the cdc was saying that i was protected against covert even being even having some dramatic from it. Hey so fifty. Percent of infections have been reported. According to the cdc wrong. That is completely wrong. Which is why. Scott gottlieb says we may be much closer to the other side of this peak then. Cdc's leading on other assumptions. They make wrong. They assume that for masking masking is going to be incredibly effective that source control meeting your ability to infect others. The masking prevents that by forty to sixty percents now. All of the data that they gathered unmasking efficacy were always very shoddy these were always very shoddy not real world data but even assuming that those data were correct the source control forty to sixty percent effective is again scott gottlieb saying not me. Those numbers come from control of the flu. The flu virus is much less transmissible than delta. Which apparently is transmissible was chicken pox so it is quite possible. Source control from mass is way lower than forty to sixty percent especially depending on the type of ask and malakoff mascots waylon that zing personal protection is twenty to thirty percents effective. Hey so masking in other words is not necessarily going to do very much here and as we've already seen in the uk you don't need a mask man. They'd in order to come down the other side of this particular hill k. Meanwhile they also assumed by the way that there will be no adjustments for other intimate interventions..
The Rubin Report
"symptomatic disease" Discussed on The Rubin Report
"To masks is better than one mask. But you don't have to have double masks is that right. I mean it became clear that cloth coverings that you didn't have to buy in a store that you could make yourself adequate. And then he wanted to fit bennett. So one of the ways. You could do it if you would like to is. Put a cloth mask over which actually here and here and here will you could get. Leakage in is much better contain double nascar. Dr fao g. We should have played the looney tunes theme song in the background of that thing. I mean tell me that is not absolutely incredible and are you going to tell me also that oh. The science was changing the whole time with that last year and a half while he was doing that that you know when you touch your face more because the mass that actually causes the problem. Is that not a problem anymore. Now that they want masks on us again and he also says masked might make you feel better right because they don't do anything now mask again even though you're vaccinated anthony fao xiaojie if you're watching this show. I am but a humble youtuber. But i have a recommendation for you retire. Go away just disappeared. Nobody's gonna come looking for you. We don't care where you go go down to florida where they've got to santa's not masking people. Because i have no doubt that foul. She is not masking himself privately at his dinners fao by the way as you probably know is the highest paid person in the entire federal government. He makes over four hundred thousand dollars a year. I have no doubt that he's also making all sorts of money from investments related to vaccines. Just no doubt that. All of that stuff is part of this I don't know how you can trust that guy. How can you trust that guy. How can you be someone who has some semblance of a functioning brain and at this point. Trust what that guy says. Trust when joe biden says if you're vaccinated now you do have to do. Joe biden or his handlers. Did nobody had an inkling that perhaps the virus was gonna mutate that. Perhaps there was going to be a variant and everything else and now there's some really extraordinary stuff. So swiss policy research group has analyze some data coming out of israel and this is really really incredible stuff. So let's let's listen to this. It's three bullet points. It's really extraordinary. Actually the latest data from israel which has primarily used the pfizer n. A vaccine indicates that vaccine effectiveness against delta corona virus infection and symptomatic disease has dropped from about ninety five percent to forty percent whereas effectiveness against hospitalization and severe disease. For example low blood oxygen levels remains at eighty to ninety percent see chart above comeback me for one second so in essence. What they're saying there is if you're going to get the milder version of the delta variant that it could help a little bit but that's not the way any of this was sold..
The South Florida Morning Show
"symptomatic disease" Discussed on The South Florida Morning Show
"And it's the right and the responsibility of afghan people alone to decide their future and how they want to run their country. Yeah which is the same. It was twenty okay. I'll put it at nineteen years ago. What changed nothing changed. It's not going to get better. It's not going to get worse. it is what it is. You know i guess the concern here is because you and i are both on the same page when it comes to get the hell out of there can you know. Bring everybody home unless there is an objective to achieve. Where is something to win. It is a national security threat to us. Otherwise get out right. And i mean at this point. What else can you achieve. Other than just policing i mean i. I don't know but you know. Of course you have a lot of people complaining saying well. The way relieving is wrong. You know we're we're letting the taliban takeover we're not leaving the afghans with enough resources to fight the taliban so how true that is. I'm not sure because on that the that's going to happen anyway eventually. I don't know if there is a right way to leave. That's you know we should have done it years ago. I was just so sick of month after month and year after year of american service gets coming home mangled or dead. Yeah for what sick of it. Just sick of loss of american lives over this mess with you know more. Maybe there is a better way as far as the way that we're exiting. I mean if we really are leaving them with you know scraps as far as the afghan forces mean help them out a little bit before you leave so that way they can at least fight the taliban when we when we go know. That's another thing too for twenty years. Shouldn't they have been trained up to where it could actually handle something. Obviously a generation of like new soldiers. You could recruit to actually. Yeah is it that. I maybe it is. I don't know. I don't know but the but the withdrawal has been accelerated so that's it august thirty. I think that's it. That's the underdog actually and maintaining authority. Diener until then. Okay sure sure. You're eight some annoy news about the pfizer vaccine. I don't know what to make this. What is going on here. Pfizer says it's starting to see immunity. Wayne wanna see that in those protected from covert with its vaccine. The pharmaceutical company says a data shows the vaccines ability to prevent infection and symptomatic disease. Search to cook declined. Six months after being vaccinated. Here's the problem then not talking. About how much decline. That is a little tiny minuscule amount or is it like a lot but it says the ability to prevent serious illnesses still very very strong so maybe they have to report it because it just loses a little bit but definitely not what you wanna hear. Because now they're going to grab this in the those who are pushing the delta variant and the omega variant in this eight variant and all this other stuff you're gonna hear forever and ever going to jump on this and say see. We can't go back to school right. Wait now that's that is the thing that you know they will latch onto this like. Oh well the third shot now before. The teachers are allowed back in school. Hopefully that is not the case because that would be very very distressing. Well either way. Here's what is in the news story from pfizer. The company does plan to seek fda emergency use authorization for a booster really..
The Big Story
"symptomatic disease" Discussed on The Big Story
"Twelve and ups or the eighteenth ups so you know with with the with children. I think that what we have to make sure first of all is that we're not giving them a dose that is much larger than what they should be receiving especially for marnie vaccines. We know that they're very immuno-genetic they can be very reacted genetic. I e you can have like immune side effects from them and we know kids do have a very robust immune response as well and so we want to make sure that those were giving them does not put them at a higher risk for having side effects. And so as we're seeing you know with the marnie. Maxine vaccines there. We are seeing reports of myocarditis happening at a higher incidence rate in younger people than than me see them in older people. Partially this is because myocarditis tends to occur in younger people more often than older people anyway. So that is in general but we want to make sure that things like myocarditis. There's not any. It's not much higher in younger children. And if it is than should do we have to look at different. Those are just if you have to look at different durations. Do we extend the interval in this population. These are all things that we have to look at so we need to make sure first of all the dose at they're getting the right does for their age group and then we have to make sure in addition to advocacy that. There's no other safety issues. That are occurring with these vaccines and children. You mentioned that delta's now becoming the predominant strain in ontario and in the rest of canada. We've gotten a couple of questions about how we know that the current vaccines are effective against delta. As you mentioned earlier. I think it can be really intimidating to see so many different numbers claiming to represent the same thing. So what do we know about vaccines and delta. I think what we know for sure at this point is that having two doses are complete series of vaccination is key for delta. And so you know goes back to the conversation on mixing and matching emory. If you've got five for your first dozen you're not able to get pfizer for your second. Does the the only by decision in that in that scenario would be to not get a second does or delay or second does and that's because getting to dozes is so incredibly important against delta. We have some data showing that efficacy or effectiveness against with against delta symptomatic. Delta with one does is only around thirty three percent for both astrazeneca as well as for pfizer but it jumps up to sixty and eighty percent for astrazeneca adviser respectively. And i think that what we need to also keep in mind. Is that what we're seeing now in. Uk and israel is that delta is highly transmissible. in fact it's at least fifty percent more transmissible than alpha which itself is fifty percent more transmissible than the original wild type. What we're trying to understand right now is whether delta can escape immunity and if so to what extent do that we see a decrease in neutralizing antibodies. But we don't anticipate any changes in t cells. Which is your other half of immunity. And so what we. We've been seeing so far up until last week was that the vaccines were exceptionally effective against symptomatic disease against delta. Unfortunately today i think you know. I don't know if you've come across but there's been a lot of new reports have come out basically today from uk and from israel that is showing even lower vaccine effectiveness against a closed. I was going to ask you about this. Yes oh around sixty percent so you know what they're what what we saw what we're seeing in israel and uk is that the efficacy seems to have for symptomatic deceased seems to have dropped from like high nineties to sixties but the efficacy against severe illness still remains high at over ninety percent. And so that is extremely. You're like of course you know haas's -ation in debts are lagging indicators. But we would have seen something by now and we have not so you know. That is extremely reassuring. We'll we are also seeing is that you know. A large percentage of the cases are in those who are unvaccinated in the cases that the people who are vaccinated. We're not seeing a subsequent increase in severe illness or hospitalization in them. The other thing. Also you know i think that sometimes headlines can be misleading. And the reason for that it's called base rate policy so first of all. We know that no vaccine is one hundred percent efficacious rate. And so if you have a large percentage of your population that are vaccinated. The number of cases in the vaccinated will increase. That's just bound to happen. So what i when. I mean base rate when i say basic policy what i mean by that is that say for instance you have a population of one hundred people and every single. One of them has been vaccine. You have one hundred percent vaccination rate in them you end up having one case of breakthrough cohen. So while you only have one case it translates two hundred. Percent of covert infections are in the vaccinated. That's your base rate policy and you're going to see more and more of this. As higher percentages of the population get vaccinated. The bottom line on delta is that yes we still need more data but so far what we're seeing seems very reassuring it does mean however that we have to continue to ramp up second doses like that is asking non-negotiable. We need to make sure we're going full steam ahead but getting everyone their second doses but it also means that we have to be more vigilant and we have to continue doing some of our non pharmacologic interventions to protect those who are vulnerable in communities. Such as those who. I mean a compromise. They may not actually mount an adequate immune response with even despite being vaccinated and then of course children who are not able to be vaccinated yet so i mean it looks good so far we need more data to come out on this but i am very reassured by the fact that even though you're seeing more symptomatic cases off of covert with those who are vaccinated. They tend to be generally mild illness. Sabina thank you so much for taking the time to explain all this stuff to us again. We will probably get more questions after this episode air. So maybe we'll check back in with you later this summer. Absolutely i'd be more than happy. Do thanks for having me. Sabina von miller clinical pharmacologist be best smart person to ask dumb vaccine questions to that. Was the big story for more head to the big story. Podcasts dot ca. Find us on twitter. Ask us questions. We will try to get them answered. We are at the big story f. Pin if you don't want your question public just email it to us will leave you anonymous. The addresses the big story. Podcast all one word all lower case at our ci dot rogers dot com and anywhere. You get podcasts. You will find this program if they let you leave us a rating. Leave us a review. Thanks so much for listening. I'm jordan heath rawlings. We'll talk tomorrow..
AP News Radio
The Latest: Pfizer: Vaccine effective up to 6 months later
"Fizer has got some new information about its coronavirus vaccine Fizer says it's ongoing study finds its vaccine is one hundred percent effective against severe disease ninety one percent effective against symptomatic disease even six months after the second dose and there are no serious safety concerns as Fizer which made the announcement with its partner by on tech companies say the vaccine also appears to work against a variant first detected in South Africa the Fizer vaccine is authorized for those sixteen years old and older I made a fall away
AstraZeneca Releases Updated Covid-19 Vaccine Data Showing 76% Efficacy
"This was seriously weird. Turn of events for astrazeneca. This week monday morning. We got the highly anticipated face. The results from its. Us trials seventy nine percent efficacy which came in better than expected but later that night at about midnight dr found institute released a statement saying the oversight board said those were data so now astrazeneca has given us the updated results just two days later and the numbers. They really didn't change too much now. Seventy six percent overall efficacy against symptomatic disease the efficacy against severe disease state and one hundred percent in people over sixty five and actually went up five points to eighty five percent and they did have a lot more cases to count here one hundred ninety as of today's results including eight severe cases strengthening that finding from one hundred forty one and five severe cases on monday. Guys how to folks looking at this after seeing kind of rollercoaster. We've seen this week and just saying the vaccine looks good. But the communications have just been awful. Dr not had bedell tweeting quote at this point. I'll just wait for the fda submission packet just to avoid any more roller coaster rides and a guys. A lot of people will be looking forward to seeing those data when astra zeneca files which they had said would be in the first half of april with the fda then three weeks later we should see fda's analysis of those data and we'll get to look at all of it itself but this has just been a weird ride made even more weird by the fact that these updated data didn't really change that
The Boxer Show
AstraZeneca updates report, insists COVID vaccine highly effective
"AstraZeneca counted additional illnesses left out of its disputed US safety study. The updated numbers show the covert vaccine candidate is 76% effective against symptomatic disease instead of the 79%. AstraZeneca claimed earlier in the week
Morning News with Manda Factor and Gregg Hersholt
AstraZeneca vaccine faces another setback after independent board questions trial data
"To the covert vaccine supply in this country is on the way. We get more from ABC News correspondents, definitely Ramos Biden administration announcing plans to ship 27 million more vaccine doses that's five million Maura than last week, including four million doses of the single dose Johnson and Johnson shot and 62 days since taking office. More than tripled vaccine output from 8.6 million doses 27 million doses. Officials in the Bidet administration, however, not confident that Johnson and Johnson will meet its own deadline to deliver 20 million vaccines by the end of March, despite the company's saying they can deliver. Obviously we're holding them accountable and working closely with them. This comes after AstraZeneca released promising results of its U. S vaccine trial. But just hours later, the National Institutes of Health questioning the findings, saying the company may have included outdated information. AstraZeneca reporting its vaccine was 79% effective at preventing symptomatic disease and 100% effective at preventing severe disease and hospitalization. The company acknowledging those numbers were based on data through mid February and is now promising to turn over newer data within 48 hours. 28 States have announced plans to green light covert vaccines for all residents who are 16 and older and those shots can't come fast enough Covert case is increasing in 16 states by nearly 10% just this past week. And there's good news and the treatment for covert Regeneron says data from their trial shows its treatment for Cove. It cuts the risk of hospitalization and death by 70% when given early on an infection and what could be a
Global cases falling. Is it the vaccines or something else?
"And around the world with starting to see cases full and they've been falling for a couple of weeks. Now which is great news outside of australia out. A wonderful little bubble here. The pandemic's obviously Causing a lot of havoc overseas. And so the question is norman. Is this just the tail end of a pandemic curve that we would have expected anyway or are we starting to say the vaccine at work. Now the answer is nobody can be very sure. But what i can say. Is that in people. Want to go back in the health. Report podcast. I interviewed chris. Murray of the institute of health metrics evaluation university of washington seattle and they're they're amongst the best models internationally of the pandemic and i think it was in november. He predicted that you would see. At the end of january beginning of february. They predicted that the pandemic would fall off. Are we mentioned this. On corona cast as well didn't we at the beginning of the year. Yes yes and the and he was saying that was independent of vaccine so in other words they weren't factoring in the vaccine at that point. Vaccines were really just getting going at that point and it was hard to know how how is going to evolve. And you where you were gonna get maximum penetration of vaccine so it was early days in the vaccination strategy so they didn't really factor it in his feeling. Was i think from memory that this is partly seasonal. The maximum effect winter had been reached. Even though there's obviously a lot of cold weather to go and that he felt that was the reason. And you have to assume that vaccination may well be starting to have any faked remember cases around the world. Very because usually it's somebody who symptomatic who's going to have a test and that becomes a case of covid nineteen but it's mixed in recent cases in there as well so it's the the definitions vary from country to country but nonetheless you would expect the vaccine to reduce the number of people. Coming forward for testing was symptomatic disease. This probably would have happened anyway without vaccination and it's going to accelerate presumably with it. Yeah i mean we've had millions and millions of vaccines all that now in the data that we were talking about a few weeks ago out of israel seem to indicate that we did a few weeks. People had a fairly good protection from the virus off the vaccination and so yeah the world health organization the night before last said that sixteen percent decline compared to the previous week intensive case numbers. And also very heartening li a ten percent decline in the death right from the previous week as well a lag obviously to the deaf rate or the number of deaths and i think that what we still don't have a fix on is what the covid pandemic is doing in low income countries. And we just need to remember that within low income countries this is not just a an ethical and humanitarian issue. This is a selfish issue for us as well. That new variance can emerge from low-income countries. If the pandemic is still running relatively unchecked in those countries. And if that's the case and you've got the fall is where they're doing more you're seeing is more. They're doing most testing. We don't have full visibility in what's going on in low income countries and the pandemic continues and the effect of vaccines is not kicking in. Because they're not vaccinating then you've still got the virus circulating with all the mutants that are being thrown off and those can spread and if we want control this pandemic and stop new variants emerging. We've got to immunize low-income countries. With a very high degree of probability. It's not just for their sake. It's for our six two. Yeah absolutely the virus. Can't mutate on. Its iron at cop mutai if it's sitting on a bench top boy. It can only mutate when it's in your body replicating and the more people it's replicating in the more opportunities. it has to mutai. That's right and most of these mutations will be harmless mutations like the one we were one we were talking about all last year but now the risk is that the mutants that the the the vars throwing off remember the virus does not have a brain. So it's not intentionally doing. This is throwing off mutants and four. The pressure of evolution is directing some mutants to survive. Where others couldn't your social distancing you'll get mutants that are surviving which can get around social distancing which means they're more contagious like the u k variant and as we vaccinate so you've mutants that are resistant to the vaccine will start to preferentially survive. So we just gotta get immunization out as quickly as possible
Will a coronavirus vaccine *actually* stop you getting COVID?
"Today is stuck to kirsty short from the university of queensland. Welcome kissy thank you very much. We've got heaps of questions to put kosti but they also have clustered around a similar theme which is about the vaccine and what it can and can't or has been proven to do what it hasn't been proven today so one of the things that we've talked about quite a lot on current cost is the distinction between whether the vaccine can stop disease in someone who's infected with covid whether it can stop infections at all. Why would we even be making this distinction. Yeah look this is such an important distinction to make. And i think at sometimes a nuance that gets lost in all the discussions of the various craven nineteen vaccines. The reason it's important to make this decision is because a vaccine that protects against just disease is great. And that's going to really really important job. In reducing the number of people that are hospitalized and really sick with covid nineteen but there is a risk that if the vaccine only protects against disease and doesn't protect against transmission. If you do sort of staggered introduction of the vaccine into the population you could have have individuals who vaccination that potentially become sort of silent spreaders of covid nineteen in so far as they don't develop even maybe symptomatic disease but if they can still be infected and transmit they could pose a risk to unvaccinated individuals. So it's really something that we need to dr and we need to watch and it's really something that we need to factoring into her in terms of how the vaccine is rolled out in the community disposable people who don't understand a to understand either is how you can get protection against disease and not against the virus and i think it's it's a really good question and it comes down to a little bit of the anatomy of at the viruses infecting. So if you imagine that a vaccine protects really well you'll lower respiratory tracts. He talking about your lungs and that's really important because you can imagine that as soon as you start getting inflammation virus replication in your lungs. You're gonna get very sick now. Think about your upper respiratory tract in contrast and. That's sort of we're talking about yours now if you get far replication in now you might not get that seat because it's you right and that's not the primary side of gas exchange but it might be really easy for the virus to transmit so once area is if you have a vaccine that protects the lower respiratory tract very well but not the opera spiritual tracked you could have scenario where you have a vaccine that protects against severe disease but it doesn't protect against disease transmission
The Bio Report
A Quest to Extend Life through Early Disease Detection
"Joe thanks for joining us here. We're gonna talk about quenching. Its effort to use technology to detect disease at its earliest stages. And it's audacious goal of extending life by ten years within a decade a i. I'd like to start with the u. Quenching grew out of a a lab that iran uc berkeley You have a masters in economics and a master's in psychology. Your career began in the advertising industry. With w p p and omnicompetent. How did you find yourself working with artificial intelligence and next generation sequencing to transform medicine. Well in a way. It's the circus is closing. So when i was born. I was born into a household of scientists and my mom and my dad bio scientists microbiology Next plank bene- germany and my whole life. All the way up to nineteen was busy just biosciences. I heard it every every day. Counted always intriguing. Not intriguing enough to make me study medicine. Which goes of the wanted me to but i found other things also interesting is typically economics in psychology and so for the first nineteen years busy got the not just a crash caused very intensive course off mike about d by chemistry and so i was very familiar with a whole field then decided you know the other things too in the world that i wanted to explore the advertising and marketing angles more random because i was moving on the strategic side of things and from there i found actually even though i loved you know thinking about innovation and growth. Which was my my main objective. At these elijah marketing firms. I felt more drawn to a financial side of things in it's via transition more into kind of strategic planning and finance. These are very large organizations of it by their doing marketing. Also have wbz's in two thousand employees. It's not a small firm and from there you know i did some strategic acquisition things for them and they had gotten in touch with startups a lot and i decided i wanted to actually switch sides and doing do something much more. Entrepreneurial did this worldwide in the us young then the entertainment circuit beck abbas busy looking at different industries from more from an investment perspective and you know biotechnology became more and more important Starting two thousand fourteen fifteen because some sequencing confidence of sequencing innovation and a and cloud systems reach a critical mass that enabled you know something. That's amazing new age of precision medicine. And you know. I was looking had multiple industries but that really caught my eye and brought back these memories from my first nineteen years and i felt very comfortable jumping a little deeper in looking at different technologies and then by a series of coincidences led to the point where i realize now we are truly at this complete in point in medicine and biotech and then all these things came together right my my bio bake around my financial background in my date of bakery digital bitten finance and Ended was as perfect confluence of really liking biology and details of sequencing on the chemistry left side But also the combination with complex cloud systems artificial intelligence and of course business model innovation. Which was a part of my career. These ten years of graduating college Yeah there's all comes together in this would be the future of medicine. He was gone gene. And our ambitions goto extent you the human life span by ten years within the next ten years and dad's executive technology stack. You need to do that. You need biochemistry. Sequencing cloud systems ai in a deep understanding of business model innovation. The company as i mentioned has rather ambitious goals for transforming medicine. What's wrong with the practice of medicine today. It must be ironic. Miss you asking there. But i can. I can outline that. The biggest there are two things that are really wrong about what's happening today. And these two things resulted in you know. Hundreds of thousands of american lives being lost every year. Like talking about covid. This is a much much. Bigger problem in kuwait. Just has guesses so two things wrong. Unim- on the medically process sites that the feet of medicine still fundamentally follows. The idea that medicine is about treating disease treating symptomatic disease and when you get how people die today. What are the biggest causes of death. It's cancer it's cardiovascular it's diabetes and metabolic diseases in its new problems. All of these are chronic diseases. And all of these diseases cannot be dealt with on a symptomatic basis. You cannot wait until you have alzheimer's and then try to do something about it. You cannot wait until you have late. Stage metastatic cancer. It's just too late so the first problem is ed. Medicine is reactive and symptoms driven when it needs to be proactive and prevention driven and ought to get their many things. Have to fundamentally change Need to be data driven the level of precision foreside statistical understanding to be a higher by by many many many magnitudes. That's problem number one. And the problem too is the business model of health care And i'm in the middle of this right now because we also started doing cooler testing and god reimbursement and things like that.
So what's the deal with this new coronavirus strain in Adelaide?
"I'm health reported taken tyler. Opposition and journalist author norman swan. It's thursday the nineteenth of november. Big day yes. Big day especially for people in south australia where yesterday we were hearing that. Not only have a south. Australians going into an incredibly tough lockdown but a short one. we're also hearing the chief public health officer nicholas spirited talking about how this strain that circulating at adelaide ease different. It's shorter incubation period. People with it don't seem to have as many symptoms. What do we know about this strain in adelaide and it truly is different or if it's just looking like it's acting differently. This was said during the crossroads motel outbreak. In new south wales when the virus spread from victoria it was said there was a shorter incubation period. More likely to spread E- symptomatically and explaining why there was a really significant superspreader event in that hotel in new south wales. Now we've not heard very much about that since that was certainly at the beginning. Now the saying the same thing here. Now i've i've spoken to a couple of people who kind of know how this virus behaves and they wonder whether or not in fact what's going on is that you've actually got super sporting events and they're so significant the super spreader events. You start to wonder whether or not the incubation short and could be true. It's still not clear what the virus is. What the subset of the covid nineteen viruses. The has been a stream code in for three nine k which has been picked up in south australia. It's not entirely clear whether that's the form that circulating not that's one that's growing uk europe and really quite common there. It's on the spike. It's where it looks the so-called h two receptor which is how you get the lock and key mechanism going into the The cell and people have looked at various strains and wondered whether or not there are significant characteristic. So what what are they talking about here is to use technical terms a short replication cycle. In other words it replicates very quickly but it infects people and the more like. It's more likely to cause a symptomatic disease upfront. That's the kind of picture that i suspect. The chief health officer in south australia was Was communicating whether that's going to bear out when you look at this and when you compare the data from europe i mean clearly it's coming from the uk. Certainly this in forty nine k. is coming from the. uk. The have been suggestions in the uk that they're getting some short incubation periods viruses with a symptomatic spreads. Certainly you've got a lower mortality rate but hospitals are filling up. So i think this is a story that had to pan out but it's clearly spooked the authorities now. The you cannot separate the lockdown from the belief that this is a short replication cycle more infectious virus could spread he symptomatically. That's what they believe. You got to try and extinguish this virus. You've gotta get outside australia and the only way to get this virus outer and extinguish it. 'cause you don't have any anti viral treatments is by lockdown and stopping people from mixing and stop them sharpened quickly and stop the virus spreading. That's the way to extinguish the virus. I'm reminded you had james hatfield back in march if you can remember back. That far on the health report norman. And he made the point that the golden rule of networks basically the family trays viruses. is that if it looks like the virus is behaving differently. Ninety nine percent of the time it's actually because of the epidemiology or the way that the humans the house of the virus are interacting with each other so could not be possible that it's just the way were behaving rather than the virus itself. Yes exactly that's the point. I was making a few minutes ago. Which was that could be. Just had some really quite dramatic super spreading events that were worried about. Its pizza parlor. Four thousand people for goodness sake are in isolation although now it's the whole population that's an isolation you also could. Well be the the behavior. Rather suddenly an appearance of a new strain that scott these characteristics particularly when the strain that hit from victoria into new south wales there were saying the same thing and they went quiet on that because in the end i don't i'm not so sure that the virus that they got into new south wales was so terribly different from the one in victoria and i don't think people were arguing victoria that it had particularly unusual characteristics.
Science Magazine Podcast
What happens to all the other COVID-19 candidates when the first one is approved?
"Now we have staff writer John Cohen. He wrote a story this week about an interesting question what happens to all the other covid nineteen vaccine candidates when the first one is approved. Hi John. Hi. Sarah. How are you? I'm good. He could be let's be honest. We're both sick of the pandemic. Yeah. Absolutely. Let me leave my house that my child leave the house. That's all I want to normal. Yeah. Normal. Let's talk about vaccine candidates. How many are in studies now under study now and what does the trial landscape look like at this moment? Know they're forty two in human clinical trials according the WHO list? The World Health Organization doesn't update list that was as of October second in there about two hundred in development. Of, the forty two in clinical trials tanner in the last stage of efficacy trials, the phase three, we're going to be mostly talking about what's going on in the US those numbers reflect worldwide vaccine development that's global. The US has four efficacy studies underway right now, and these are all part of what they like to call warp speed all part of operation more speed. Yeah. Yeah and so they're going through trials going through all the same steps, but that could change once one of them gets. Approval, why would something changed about? You know what's going on with the other CO bids scenes? The concern is that the mediocre might be the enemy of the better or the best the way that we've set things up in the United States the food and Drug Administration has a mechanism called an emergency use authorization. It's received a lot of attention because of hydroxy chloroquine because of rim, Desa there, and because of convalescent plasma and because of diagnostic testing, all of those have used this pathway for. Approval and authorization essentially is short of a full approval and it says, Hey, were in an emergency we only minimal data that gives us an idea of this stuff working and then we'll let it be used widely. So why are we worried about the other possible covid nineteen vaccines? If for example, one gets a UA by November I the FDA has said in a document issued in June that the EU a could be issued for fifty percent efficacy. That's a pretty low standard to begin with. As. Soon, as you authorized the use of one vaccine, first of all, this is an ongoing study because they're going to use data for an e you a most likely from an interim analysis someone of axion efficacy trial is scheduled to take six months. An Independent Safety Monitoring Board looks at the data at certain pre scheduled time points in the case of these efficacy trials they look at. The data early based on what they call? It's are basically the end points of the study. The studies are primarily asking the question. Do they prevent symptomatic disease that the number one question they're asking? So that's an event. If somebody gets a symptomatic disease and these trials are scheduled to have one hundred and fifty events to reach their final conclusions, but they're going to take peaks at the data. At fifty events, a net one, hundred events roughly at fifty events a company. If it had strong evidence that the people in the vaccinated group as opposed to the Placebo group were doing better, they could seek you a based on fifty percent efficacy at that moment they ethically in a quandary because the people who are still in this trial, blindly a receiving either vaccine or placebo ethically you could. Argue you've gotTa Blind and tell the people who are receiving. Placebo. We've got a vaccine that looks good. Do you want to get it? So you've undermined that study from reaching it's real and points of one hundred fifty events What's more? Every other study underway has to let the participants know that the US has issued and ethically you have to give people the option of taking a vaccine. The FDA's blessing. People might walk out a trials who are in trials. If you were staging a new clinical trial, you may well have to compare your vaccine to the one that has received the authorization. Well, it's much easier to prove that something is better than nothing. But what if you have a vaccine that's fifty percent effective and that becomes the competitor not a placebo well. Then, this new vaccine let's say it has sixty two percent efficacy. You're comparing sixty two percent to fifty percent not fifty percent zero. It's really hard to see that small difference or even if they're equivalent, let's say they're both fifty percent. So you need a much larger study and it needs to go on for a longer period of time and it costs a lot more money we. Don't have. It's not likely that people involved in trials for other vaccines or even the people in the placebo arm of the one that does get approved would have access to the sack seen. That's a critical consideration. If supply doesn't meet demand, then we have an easy you were only giving outlets twenty million doses to the top priority people healthcare workers then for the people in other. Clinical trials they have no other option. Then the issue is not this great ethical dilemma, but remember were speeding things up with operation more speed in order to pump out three, hundred, million doses of vaccine from one company by as early as the end of January. So this problem, it's not here today because supply doesn't meet demand, but it sure could be here in late. January and. February march April who knows what we're going to have in terms of efficacy data and who knows what we're going to have in terms of trials in their enrollment. Remember we have a couple of trials that have been stopped because of side effects. When you put a trial on hold that means it's not going to reach its end point for even longer and that's happening right now with two of the warp speed vaccines. In your story, we don't want just one vaccine. There's some good reasons to continue to investigate and to look further afield even after one is approved, can you talk about some of those? For one thing we may need different vaccines for different populations. The elderly we know with influenza, they need a much higher dose because their immune systems don't work as well as they age we may need one that's tailored for pregnant women. Pregnant women are GonNA, tolerate a risk factor much much lower than everyone else. You might need a vaccine that simpler to deliver for some parts of the world that doesn't have a cold chain issue or you need to keep it at. MINUS SEVENTY DEGREES CENTIGRADE. You might need a vaccine that's cheaper for many countries even though it's maybe sixty two percent versus sixty, eight percent effective, it might be a better deal at the end of the day because more people can get it for the amount of money you have on top of all that we want a lot of vaccines because more vaccines means more supply we have an insurance policy of something goes wrong at a manufacturing plant. If a side effect crops up when it goes into wider use, we have this backup of other vaccines. So there are loads of reasons why we want a whole portfolio vaccines ultimately to prove safe effective. That's the. Case that you have to make to participants people who might be involved in trials. Do you think it's going to be effective? Do you think people are gonNA still volunteer to get a vaccine or not vaccine that hasn't been approved? You put your finger on a really important issue and that's who enrolls in a vaccine trial why it's not like you have cancer that's going to kill you and you're enrolling in a trial because you've exhausted all medicines and you're hoping beyond hope that this new treatment will work and Save Your Life. That's a completely different motivation to join a trial. Then a vaccine when you are healthy, you're joining this to prevent something from. Happening so ethically, you can argue that well, that person most of these people are doing it for altruistic reasons the really doing it to help other people and you can ethically approach people in a study and say, Hey, look this one vaccine got EU a based on the early data that it's fifty eight percent effective. We'd like to keep you in this trial and it's a blinded study and we promise at the end of the study is one of the bioethicists I interviewed said we promise at the end we're going to give you the better vaccine, but will you stick with this for a while so that we can figure out if the vaccine that isn't For us is worth pursuing going back to your cancer example. There are cases where a clinical trials is happening the people in the treatment group are doing so well that it's no longer ethical to continue to deny that treatment to the placebo arm. That's not what's happening here. It is a different equation, some ethicists. That, even in a vaccine study, a person has a right to know if they're a participant whether they're receiving a placebo vaccine if there is convincing and compelling evidence that the vaccines working but keep in mind too and this is something that I think a lot of people have a hard time getting their heads around wearing a mask and social distancing goes a long way toward protecting you from this virus maybe even more than fifty percent effective vaccine 'cause then you're walking around. With none of this protection or you're not taking it as seriously exactly and that's called behavioral inhibition. If a vaccine leads to behavioral discipline habituation and people dropped their guard, stop wearing masks stop social distancing they may be putting themselves at more risk even though they have a vaccine in their bodies
The 'ludicrous' coronavirus certificate your boss wants
"We're hearing about this trend that seems to be starting with. Employers or schools or day care centers are requiring a carbon nineteen clearance. What people have to guard the pay and get basically a medical certificate? Saying that they're not sick and the Royal College of General Practitioners has put out a statement saying please don't do that. For number of reasons, chiefly, because it's kind of impossible, that's absolutely right. Employer should not be asking employees for that sort of proof, because the proof doesn't exist as we've said before you've never negative test, let's say you are infected with Covid nineteen and you get the test done on day one. It's a high likelihood of negative and hopefully more positive as days go on, so you could have a negative tested means absolutely nothing, and even if you're not infected the day after you do the test, you could be infected and the day before test doesn't matter, so you're going to have the test every day before you get to work. It's completely ludicrous. Ludicrous and really not the way to go, and what really should happen is that people with symptoms should not go to work and be tested to make sure they're not positive, and then even people symptoms shouldn't go to work, even if it's the common cold, or it might even be the flu and you gotta wait interval symptoms settled. We don't have to be isolated for two weeks. If you don't have covid nineteen, the difficulty with this is that GPA's at the moment especially more. I've alerted than ever. The last thing we need is more people trying to vie for that really valuable time. Jupiter are probably not that busy at the moment actually. Doing a lot of telehealth consultations, the surgery's going back into action, but the reality here is that you're asking for tests really meaningless in in the absence of the likelihood that you might be infected I think it's fair enough. If you're maybe a little bit of symptoms, you into a protest, you want to get tested. That's fair enough, but to ask this on a one off basis for a line to say the you're covered negative on one occasion. When in fact you might well be positive is ludicrous. So what should you do if your boss does ask you? You for one of these medical clearance certificates well I. Think should show them the release from the Sterling College of General Practitioners and we'll put that up on our website and you can find. They're pretty often. Take it in one of the things that they do say in their release from the pay is that there's not an unlimited number of tests which is of course true. What do you think about this? Perhaps discouraging people from getting tested because they don't want to be wasting them. There are plenty of tests. People need to test. They should get it done. But the would I mean would put an unnecessary extra burden on testing, and there is a cost attached to that, but we've got plenty of tests. I wouldn't worry too much about that. So question from Perry about why people is symptomatic. She's asking to raise such as why some people is symptomatic. Is the viruses only mall in these people? Can it be savvy and they still show no symptoms I think she's talking about viral. Load here, so let's be clear what we're talking about here. So this is somebody without symptoms who is covered nineteen positive call positive for the SARS covey to virus. That could be two situations one. Is that your? Throughout the course of your infection and the other. Is that your committee that you're having any symptoms yet? But in five to fourteen days you will develop symptoms, and so the reason why you could be asymmetric. Right through the course of your disease is that you got a very small doors of the virus? It's likely that the doors you get an. Organism, is related to the severity of disease. One reason why healthcare professionals can get very severe disease, so if you get a walloping doors of the viruses likely, you're gonNA. Get A walloping case of the disease. It's not true in everybody, but that's one reason so. That, you could be symptomatic. Probably the biggest reason why people symptomatic is their age and children beyond one year of age through too young I don't who'd through to fifty sixty years old, the likelihood of getting symptomatic disease increases, and it's almost certainly do in that case to the response of your immune system, because essentially symptoms like coughing sneezing feeling fatigued, are all symptoms not so much of the virus, but of your body's reaction to the virus, so it's like getting an immunization in your. Your arm it goes red and inflamed that your immune system responding to the immunization, and it's a good thing because it shows that you're reacting to it and similarly with your body, so your body is reacting strongly immunologically. Then you're more likely to get symptoms, and of course this severe covid nineteen disease is actually a disease of the immune system. It's an overreaction of the immune system doesn't mean to say if you get a few symptoms like fatigue or Or loss of taste, and so on that you're heading for severe disease, but it's a sign that your immune system is reacting quite strongly to the virus, so those are the two reasons those of the virus and your immune response related to your age in particular,
Wisconsin's Morning News with Gene Mueller
Protests spark fears of new COVID surges
"What happens when protests and demonstrations meet a genuine viral threat Dr Jon Rubin is the CEO of the medical college of Wisconsin is joining us live on WTMJ good morning Sir thank you so much for your time soul the tendency I think among some people lose that cincy for home got lifted the virus went away that obviously is not the case now add in the fact that people are being so active socially and politically with street demonstrations and such I would imagine this is just gonna be like a Petri dish for this virus to spread thanks thanks so much for the questions you have and it's an important one you know we did see our largest three day total of new covert nineteen cases last week what about seventeen hundred cases from Thursday through Saturday and that is of significant concern on the other hand we're not seeing a huge spike in hospitalizations or deaths at least not in the last week with regard to the protests at Lancaster by knowledge and the pain and anger that people are feeling about the killing of George white and the longstanding frustration about the slow pace of dealing with racism and racial disparities so no one in minimizing anyway the reasons why people would allow ranger which exercise our right to protest peacefully but I am concerned about the potential impact of the protests not just because of crowding in the fact that some people were wearing face coverings but also because we know African American and Latino populations and other disenfranchised minorities have a higher likelihood of contracting culvert nineteen and minorities have worse outcomes especially African Americans you know on down to lead their issues with the healthcare system that need to be addressed also including an inequitable access and unconscious biases some of our providers but I I do think the problem is a reflection of many contributors to health especially the social determinants of health any of those under guard a lot of the protests doctoring and some people are taking a met wearing a mask and and turning it into a political statement can you clarify what good masks do what good wearing a mask does yeah thanks for the question Jane this really shouldn't be a political issue this is an issue of Kurdistan solidarity what we know is if people wear either a cloth or paper paper update covering that they reduce the spread of their own respiratory droplets when they call cough or sneeze and that's really important way that we can prevent spreading cut a symptomatic disease to other people many many people now know that covert nineteen can be spread when you when you feel perfectly fine and in fact you may be your peak level of contagious missing a day or two before you start your own symptoms Dr at the beginning of this I think a big part of slowing the curb was to alleviate pressure on health care workers how are they doing it have we progressed in terms of trying to take some of that pressure off of hospitals and health care workers yeah thanks for the question again we're doing really well in Wisconsin I think we were fortunate that we were weeks to months behind some other municipalities and we learned a lot about the virus just in terms of how to take care of patients who need to be admitted to the hospital and who needs to go in the icy use so I think we're doing reasonably well we do want to make sure that people continually social distancing good hand hygiene and making sure that they're careful about talking coughing sneezing around other people so that we don't have another surge that can overwhelm the capacity of our health systems really don't well here Dr John Raymond the CEO of the medical college of Wisconsin joining us live on WTMJ only got about a minute left but I wanted to ask you there's a a conventional wisdom being spread by some that this thing is going to cook out as summer is upon us that the bug is going to go away got up to ninety plus yesterday so certainly felt like summer is there any truth to that well we all hope that it will go away but I would say that the evidence is a weekend that there's a weather related factor with covert nineteen factors take a look at the southern hemisphere more it's been warm and there's been very significant spread of the disease so we can hold but I would still say let's socially distance and protect
All In with Chris Hayes
Bernie Sanders Campaign: We Don’t Want Bloomberg’s Blood Money
"Senator Bernie Sanders campaign manager was asked if he would take Michael Bloomberg's money in the general election and he said quote it's hard no Bernie has said he's going to fund. His presidential campaign was smaller contributions. And I think we can do that now. Last month Bloomberg pledged he would use his vast wealth to help fund whoever wins the Democratic nomination now sanders campaign said they are not interested. Bloomberg camp tells. Nbc News that is fine with them. Quote I don't think it would be prudent to spend on behalf of somebody who did not want the response raises a fascinating question about the means and the ends here. The battle between billionaire cash and Democratic Socialism. Which is just one of the main stories of the twenty twenty primary here to talk more about this is on ungeared at US editor at large at Time magazine author of the book winners. Take all in the recent New York Times op. Ed The billionaire election. I think this question is an interesting one. Actually and I'm not clear. What the correct answer is I kind of understand from the sanders campaign particularly the primary. It would look kind of terrible for the brand Bernie Sanders. But I'm also not clear if that's the correct answer and a sort of optimal sense you know I think you have to add it all comes down as we've heard again and again to this question of whether you think trump is symptomatic disease and I think if you think he's this aberration and he's the entirety of the problem. Then you might embrace any means necessary to get rid of him including taking big money if you think. Our problem is oligarchy. If you problem I think our problem is people like Donald Trump having too much power in American life in a bunch of different ways and that he's one of the people who kind of slipped into a particular luckily lucky position for him. Then you don't WanNa fight fire with fire. And I think I'm sympathetic. To the view that you don't fight a racist sexist oligarchy who cannot read with a racist sexist allegoric who can read and is very smart. You know like I just don't think that actually works and I think the question for all of us in this campaign is. Is there a way because you're right? It is a moral dilemma. Because maybe you're not gonNA registered enough voters if you don't have money maybe there's a money help because a lot of things you can do with a billion dollars in Texas of course but part of the excitement of the sanders campaign but I would also say. The Warren Campaign is the strength of the message that they are something not of this plutocratic age and any dilution of that compromises the central thing that is animating people count compromise the central emotional pull of the campaign since the Bloomberg campaign. Here defend themselves. They would strenuously denied. That he's a racist and sexist. I want to say that on their behalf the I would stop and Frisk them. They're here to check You know they were. Yeah the thing about Bloomberg that has been really interesting to watch. Here is a very complicated tenure here in New York City it was. It was my mayor some part of the time. He's complicated figure many ways and quite when he said he's smart. I mean there. There were tremendously competent. Incredible people in fact in administration in that mayoral administration. Who did really remarkable things? Some of the record here in New York City but it was always open question to me of basically like the the value proposition. Michael Bloomberg was kind of like. What if we can have our own billionaire? I mean people would say this to me like what if we can take on trump with someone who could spend unlimited. What if we can take on trump who also kind of didn't give a hack almost kind of trump and I think he didn't understandable fashion that has been continues to be a very alluring idea to people and again it is possible to fight trumpism in a way that deepens the whole of trumpism and you think Bloomberg represent says yes because the the the sum total of trumpism. Isn't this particular guy. Who's so malevolent and hateful and a White Nash? That's that's one expression. That much deeper tendency has taken right. If you think about setting a precedent where anybody with a few billion. We actually have several people. Yeah many many people who can afford to do a Bloomberg's doing he can afford it more than others. But you've got a bunch of people who there were three billion at this kind of thing. Does every person now who has that money? WanNa do that and as you can see I described it before I was just looking at his his charisma last night. Bloomberg's and it really feels like I described this morning as like. It's like a large piece of cheese at eight a robot. I mean it's just like the complete lack of ability to connect both in performance charismatic way but also an inbound way right like someone who hasn't taken in for me it's people in a really long time and that's because and I'd done reporting on these people part of being a billionaire is no one tells you the truth after a pretty early stage in your life. Let me let me let me rephrase lightly. More charitable way robot which is that. He's not quote typical politician and when he was in New York part of what he was able to do because of his money was to kind of not do the truck and barter and all the glad-handing that you have to do is a politician. New York he just has come to politics in a totally different way because they say some people like precisely that right I mean that was the donald trump sell to his electorate was. No one owns me because I own everyone correct exactly and so he did. Do glad handing of a different kind of billionaire. Kind right right. I used to wonder this. In that Era New York you would have these the arts. Go to the ballet and it will be funded not by the city but by Bloomberg philanthropies while he was the mayor and it now appears he was doing was buying people buying nonprofits buying people who fight for the most vulnerable people who might be his biggest opponents as a guy who's behaved the way he has at work or done stop and Frisk and are now silent or supportive. There's this sort of ongoing question about. I'm very curious to see what he does next in terms of his durability this electric particularly in the wake of him having to kind of defend his record like all the other candidates have to us. It's always great to have you thank you so much still ahead. Could the results of South Carolina be the end for any democratic campaigns? Who's got the money in the staying power to make it through