17 Burst results for "Serotonin Syndrome"

"serotonin syndrome" Discussed on Impeachment: A Daily Podcast

Impeachment: A Daily Podcast

04:31 min | 4 months ago

"serotonin syndrome" Discussed on Impeachment: A Daily Podcast

"They'll put that into their body so that to me kind of really speaks to the scientific literacy in the united states and how bad it is there how people don't understand what evidence is and what an arbitrary type of assertion is about some treatment that might work because of this rather than no body of evidence that that gets that gets Kind of evaluated over time and it's peer reviewed and and become generally accepted. Because it works it's reproducible all of that all of those principles of the scientific method that you learn in grade science class. I think most of this country has forgotten that another drug. I read about this week. fluvoxamine antidepressant is currently being used to treat severe kovic. Is that right. So fluvoxamine is a it's a. Sri a common type of antidepressant drug in there was an initial trial that was published in. I believe jama. That was positive that showed that there was some benefit in decreasing decreasing complications from cova nineteen. But it was a small study and it needs to be followed up so i mean does have some data behind it but again another thing that from the scientific method just remembering from your fifth grade science classes reproducibility. You wanna see more studies anyone to see them in larger swath of the population to make to make sure that this is not a spurious result and remember you lots of people in this country already. Take an antidepressant similar to fluvoxamine. And you don't want to be mixing fluvoxamine with zoloft or prozac or whatever. It might be because you could get a dangerous complication called serotonin syndrome. So this is something that needs to be studied more before it can be operationalized. There is a positive signal there. I'd like to see more studies on fluvoxamine before i would Prescribe them but people shouldn't be doing this on their own and if they are doing it make sure you talk to your doctor about other antidepressants. That you may be on that could interact and cause a dangerous and deadly reaction called serotonin syndrome..

united states Sri serotonin syndrome
"serotonin syndrome" Discussed on No End In Sight

No End In Sight

02:48 min | 6 months ago

"serotonin syndrome" Discussed on No End In Sight

"When the entire medical board was established for that purpose to shutdown other medical schools on whiteman be doctors that has shaped all of our care. This is the united states example. Although i know that that didn't only happen here onison in north america and the uk in a lot of europe like we're all coming from this same one like how do we keep everybody else out of this field by making it not helpful and kind of few i got. So this is like one of my special interest but looking at link betty Medical history and like this is because one of the things. I've always been so interested in is like. When did we get into this idea that it is dangerous to treat yourself. Because it's such a kneejerk reaction. This is a large part of why. Stop being as active in facebook. Chronic illness. I because i talk about this stuff. And i'd have my post would get deleted. They have disclaimers and understand why they're also wanted to protect themselves from why ability and they're also like there are predatory like mlm people who. Hey have you tried this. Essential oil it hard for that reason. Yeah but there's also this knee-jerk reaction that oh my god. That's so dangerous. And i'm like i've literally had serotonin syndrome because of medicine that i was prescribed. And then also the doctor didn't recognize serotonin syndrome because it wasn't on the monograph. How am i supposed to believe this is more dangerous. I it is dangerous. All of this is dangerous and like why is this. Not an acceptable informed. Risk that i can take. Why is it perceived so much riskier. It's really interesting. Because there's this case from i think the fourteen hundreds and france and it's this woman called jacqueline diffley. See choose one of the first trials of unlicensed practice of medicine and so she was a woman who was obviously very well educated because she was reading using the same tax that these among the professional academically educated doctors were using she was using the same treatments so therefore was obviously reading..

whiteman north america europe united states uk serotonin syndrome facebook jacqueline diffley france
"serotonin syndrome" Discussed on No End In Sight

No End In Sight

04:37 min | 6 months ago

"serotonin syndrome" Discussed on No End In Sight

"Really love to emphasize that it is not a stimulant. It's a wakefulness promoting. Ada they don't know exactly how it works and at least one of the past leads by which they think it works is the same way that stimulants works so it's all a lot of rhetoric. Intentionally misleading technical language. Yep it's thought to work sort of through dopaminergic pathways. It's also thought to have some. Sarah urgent action. Which in hindsight. I realize probably i was having so many side effects because a i was also on prozac at the time shockingly. I was dealing with a little bit of depression by the end. But also i also do not tolerate crtv jack medications while at all because which i did not know at the time. My mastel disorder. One of the things mass cells releases serotonin and once. I learned that plane. Why i've always had symptoms of mild serotonin syndrome. Whenever i've gone on urgent ned. Yeah so i was. Basically experiencing like mild moderate serotonin syndrome on national for months with no context for all of these changes right and like the side effects Scary my mom was like your personality and your whole affect changed on a dime when it kicked in it was wild. It's so hard. In general like med side effects. This episode will come out later than right now that the recession might have moved but when we were recording in early december kovic. Vaccines are like a hot topic. Though i feel like this exact thing that you're talking about about like yeah. This drug is like really good for a lot of people. I had every single system impacted. And it's like oh right. We don't have good side effects. Data on anything. I feel so deeply nervous about the cova. Edit i'm not even talking about on twitter because i do not want to deal with what mentions will look like if i do but i don't know if you know about this. But what are the h one. N one vaccines in. Two thousand nine is thought to have caused narcolepsy and a lot of people. I don't think it did in me. In hindsight i thought for a while it might have because my sentence started getting a lot worse. It's all complicated too. 'cause my massol symptoms started getting so much worse. I did get swine flu. I also got the vaccine. Really lucky i literally it was probably pre-symptomatic i got the vaccine and then about two days later i came out with full blown swine flu and it was in the months. After that that mastel symptoms started getting on ignore ably bad and it was over the following five to six years that it just progressively got worse and worse and worse. We jumped because of me talking about that time. Wise did much happened between like a ha it narcolepsy and then like i'm living my sort of regular life and like bow flu so actually the narcolepsy. I found out well after the swine flu. Oh yeah you were talking about it for that reason. Yeah the swine. Flu is in the first semester of my last year. in undergrad..

mild serotonin syndrome mild moderate serotonin syndro kovic Sarah depression flu mastel twitter
"serotonin syndrome" Discussed on The Model Health Show

The Model Health Show

05:46 min | 6 months ago

"serotonin syndrome" Discussed on The Model Health Show

"Efficiency. Serotonin is the building block. It's a precursor for building melatonin. Which is a well noted sleep. Regulating hormone in serotonin is kind of like the opening. Act for melatonins. Performance is kind of like the hype. Man for melatonin sleep relating abilities and also within that serotonin while sleeping helps to regulate and move us out of certain phases of sleep as well so has multiple impacts on our sleep efficiency very very important now. So these are. Some of the things that serotonin is well established to do that. Seem very beneficial but like with all things. Too much of a good thing can turn into a bad thing. And so what happens when we have too much serotonin. Let's touch on that. For a moment will this is called. Serotonin syndrome in typically. It's brought on by medications. That influence serotonin which can cause a whole host of issues ranging from acute issues like nausea and headaches to chronic issues like reduced bone density and osteoporosis. Are sarah too much. Serotonin can create conditions where we have low bone density and even osteoporosis. So that tells you right there that serotonin neurotransmitter and hormone has a big impact on our bone health. So really really interesting stuff there. Also we want to keep this in context because too much serotonin is not the issue for most folks today. It's oftentimes today. The issue is abnormalities with serotonin. In the opposite direction including serotonin deficiencies in inefficiencies which low levels of serotonin in the cerebral spinal fluid for example is associated with increases in violence insomnia excessive hunger suicide in more negative associations partly because serotonin and its metabolite. Melatonin play a major role in mood. Appetite regulation the sleep centers of our brains in regulating our sleep quality and so much more. Now this is just touching on how powerful this hormone slash. Neurotransmitter is in our bodies. But it's important for us to always keep in mind that none of the compounds of the body creates operates in a vacuum. None of these things. If we're targeting just one thing it's inherently going to affect everything else in everything else is inherently going to effect that one thing. We're targeting so let's take hormones for example. Hormones are chemical messengers that communicate and send messages throughout all the cells in our bodies are so. It's kind of like these metabolic. Dmz direct messages. That are going from cell to cell communicating these messages giving instructions signaling behavior signaling needs and when these. Dm's are starting to flood with the particular hormone for example. That kim metaphorically caused things start to go to spam and down regulate the sensitivity of that inbox for that particular hormone all right so we have to keep that in mind now..

osteoporosis Serotonin syndrome nausea headaches sarah insomnia kim
"serotonin syndrome" Discussed on Cardionerds

Cardionerds

02:54 min | 1 year ago

"serotonin syndrome" Discussed on Cardionerds

"S p o of ninety seven percent but he was on the vent at that time stars is physical exam goes was notable for he was intimated he was unresponsive. He had a present gag reflex but no response to commands or two deep pain. His people were equal and reactive. There was no neutral rigidity noted. His cardiac exam is unremarkable. He's tackle cardiac rhythm is regular is a normal s one in a normal to know murmurs out spur noted. At that time s- were clear Fully cather was placed. His skin was warm and intact without evidence of skin breakdown or any rashes. So i just have to ask shod help us user voice demonic to evaluate this patient at this point absolutely the moist demonic has all the answers. Were still missing. Some important data points that will get to later with the labs which will answer a lot of our metabolic questions. But i think there's a couple easy things that we can move up and down on our list so since the patient is vented appears to have normal oxygenation we can get rid of the owen are moist that high fever and being who refer lee warm really support the i in the moist which is infection. The neuro exam doesn't really help me. Localize any stroke. Since the patient was on picks a ban. I am concerned a little bit. That he might have had a large hemorrhagic stroke which could cause something like this the previous time course that he had leading up to this event may not fit with then for our t. i think toxins. Perhaps the fleck night would cause this change in mental status. Minimal responsiveness need for event. The fever though is probably one of the more important pieces of data that we have which points either to sepsis or some other toxin that might be causing that. Yeah i agree sean. I think the fever is such an important piece of the puzzle at this point for flick night will be helpful to see the ekg. You know your whitening and conduction delays. That were not present before and then for preah just to contextualize his neurological exam. The fact that he wasn't responsive to pain at was his patient. Like under heavy sedation. At this point perry intimation was he. Just recently paralysed or is truly oxidation. He is not responsive to deepen. Because it really changes how we approach. This totally agree. He was actually off sedation at the time of this exam. Wow so extremely concerning for fever. We consider of course infections. But we also consider other causes of piracy elect serotonin syndrome or neuroleptic malignant syndrome. That can also cause altered mental status with fevers toxic. Costs would be another one to consider also but again. We started off with altered mental status and our doing detective work with his vitals. Sumo have the ekg the medication history and all the other pieces of puzzle. So let's fill in this puzzle and get more data absolutely so in terms of other work of the was obtained in the emergency department. He had an ekg done which is demonstrated here. He was technocratic kartik but really no other significant abnormalities were.

fevers preah lee serotonin syndrome cather neuroleptic malignant syndrome owen sean perry
"serotonin syndrome" Discussed on The Drug Science Podcast

The Drug Science Podcast

05:41 min | 1 year ago

"serotonin syndrome" Discussed on The Drug Science Podcast

"I looked at plasma concentrations of. Mt. So they decided in order to get people to that state you'd have to give him twenty five milligrams. So I said, well, the principal function of the land is producing Melatonin. It makes about twenty five microns in twenty four hours, and that's what is supposed to do is it now you wanted to make twenty five milligrams of Times more. It's just not going to happen. So I got a lot of pushback and then people said, we know this and the enzyme that myth leads. Into lameda methyl, transferase I N T. Occurs throughout the body in the lungs and people said, well, what's different went to therefore, we know the First Study of Mt was done by Julius Axelrod and he took some rabbit lungs made. through tritium labeled radioactive s identify any to see what came out what came out with N Methyl Serotonin didn't get the MTA and actually I've had some discussions recently with some colleges I said what does end methyl Serotonin do because if you've got I, N? T. If that's preferred substrate. Yes of Serotonin Syndrome maybe that's an enzyme the somehow deactivated. Does it have less of as constrictor in there's no literature Ronin Tony. But anyway I said you know it doesn't make sense. There's no evidence. To match you to smoke to get an effect. Pineau can't produce that none. There's been another paper that they've done. They said, well, the the Messenger are a for an empty in the brain pinal gleaned so. That must mean is producing D. N. T. in all that there's it's just the it's scientific pseudoscience speculation. So basically I don't think that's what's going on when you have announced a funny experience, you don't need invoke the formation of endogenous GMT. But there's another area that I think is really important and there was a Webinar on psychedelic couple of weeks ago I think it'd been on it. I was talking on. The question was being raised and you've helped with this a lot was about the fight to be receptive risk with current drugs because as we know the site assigned LSD. DMC They have some impact on this five hundred to be receptor. And there's been. People using the to be receptor as sort of scam among. These drugs could be dangerous. You just explain to people know what that theory is and how you kind of dismissed it in terms of the.

Mt Serotonin Syndrome Julius Axelrod MTA Pineau principal Melatonin LSD
"serotonin syndrome" Discussed on MMA Roasted

MMA Roasted

03:34 min | 1 year ago

"serotonin syndrome" Discussed on MMA Roasted

"Let's say for sure any thoughts on this. I have a question regarding mushrooms for my girlfriend actually has an epilepsy we know she has seizures every now and then do you think there's any future or relation between mushroom psilocybe and all this stuff and epilepsy cuz I know epilepsy it's just like something's faulty wage. Wiring of your brain. I know if you take a heavy dose of mushrooms that could alter that wiring. Do you think in the future or even now if there's any studies going on with mushrooms relating to epilepsy? Oh did we we've got we've a CTI and a TBI study. We have a PTSD study that we're not just the only ones there's multiple people doing it right now. And yeah with with epilepsy so my former ex Alicia boss who was a web who was Frank Shamrock in the WWF. She has epilepsy and you know, so I'm very familiar with it. And it's that shit snarly like I'm home. I feel so shocking bad for her. But yes, so the the neural connectivity the the electrical impulse in our brain that connects everything. Yeah, that's that's from from amyloid plaques up the information. So when you when you have an anti-inflammatory diet and specifically paired up with psilocybin who has an epigenetic neurogenesis the healing of the brain matter itself off. Oh, yeah, it can help and it's a big thing is is what medicine are they if they're on an SSRI this can give them something called serotonin syndrome, which is too much serotonin in their body wash. So it's about getting them off Pharmaceuticals which are the devil. I mean, I told everybody was addicted to painkillers for 20 years. The one time I got off of painkillers. I I was the best in world, you know, and I don't care that's besides the point but it's knowing that I was able to fix myself if I can do this anyone can do it and I just have the tools to show people. Yes, you know what it costs money. I have a feed off you but but we do integration like like it's it's it's fixing the brain itself there and then dealing with the rest after do, you know the traumas and all that stuff pop up because as a child your childhood trauma, you're not going to remember cuz you're a kid your brain hasn't developed yet. But but as dr. Gabor mate through the the compassionate inquiry program that he's made he has a dog. That the trauma is stored in our tissue. So your brain doesn't remember but your body does so when you can drop the default mode Network or the fear response in your brain, you still picture your brain is a little circle. Okay, you have a circle here that your brain all your bad thoughts and traumas are in a little box in the middle. Well modern therapy can't get in there because the default Moto protects you but see when you have the fear response drop down then you can get in there and you can go like oh shit. Okay, I can deal with this. This happened to me. Like what the fuck? Okay. Well, I knew this happened but I hate it. I mean there's been serviced copy of my life. I am I totally forgot about and you deal with that and then you you don't have anxiety. So your anxiety depression all this stuff like a fighter going to into a cage. I'm a pussy because I got scared cuz I was in the in the cage know you're not you do this every day. You're a fucking sure you're a drug God. You're a fucking Champion for just being here in the first place. Okay, ma'am. It is you're in childhood traumas and addictions that are are trying to drugs that leading to addiction and leading to these this anxiety coming out at the worst possible time, you know, you're in front of all these people this pressure all the cameras and you get scared..

painkillers serotonin syndrome PTSD Frank Shamrock psilocybin TBI Alicia WWF Moto dr. Gabor
"serotonin syndrome" Discussed on Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

03:17 min | 1 year ago

"serotonin syndrome" Discussed on Real Life Pharmacology - Pharmacology Education for Health Care Professionals

"Are At. So thinking about that dosing, we need to think about adverse effects of we get aggressive with the dosing. The side effect, you're most likely to see or at least the one I've seen most often clinical practice is nausea in maybe more specifically diarrhea. So search aline has been nicknamed squirreling. Because it definitely causes. Diarrhea more frequently. Than, some of the other ESA Sarah so that is definitely one big differentiating factor. With circling compared to some of those other agents within the the class there. nausea I mentioned as well. It's important to note. That patients May. Become tolerant. They May Kinda get through the initial period and it may be okay for them to continue that. Obviously, you're going to have to look at that patient clinically. How severe is the nausea? House fears the diarrhea. And what are we going to do about it do just back off on the dose for a period of time. So maybe starting at fifty milligrams, they're having problems. Can we just back off on that dose You know if you start loads, may we can go to every other day for a period of time and then you don't ramp it back up again and and it might be okay that way. So you're GONNA have to work with patients. They're obviously we can switch potentially to another S. SRI is well that may have a lower incidence of those gi adverse effects so. Important, to think about that work with patients clinically assess if they have had any benefit. Which I'll talk about a little bit here as far as how long that generally takes But yeah important to to work with with patients on that and assess the. Severity of symptoms versus the the risk of of continuing there. Of course, all Esser is have that box warning on suicide allergy risks. Suicidal thoughts important to remember that monitor patients closely certainly as were starting in an increasing doses. A CNS. Happen Fatigue Insomnia. Dizziness dry mouth I would say it's not. Incredibly common. It as far as we think about fatigue versus insomnia, I have seen both happen So definitely, you know just just pay attention to what the patients reporting and checking in on them in monitoring them as is certainly important. Sexual. Dysfunction significant problem with s are is in general search aline is no different there. So. That's something that's sometimes forgotten about and not asked about by healthcare professionals and it might be something that patients may be sensitive about reporting as well. So I keep that in mind the important to ask and assess for that as well. Serotonin Syndrome. I'll talk a little bit more about that with drug interactions and in some medications that.

Diarrhea nausea insomnia aline Serotonin Syndrome Sarah Esser
"serotonin syndrome" Discussed on Stuff To Blow Your Mind

Stuff To Blow Your Mind

08:19 min | 1 year ago

"serotonin syndrome" Discussed on Stuff To Blow Your Mind

"Due to drug interactions can cause potentially fatal condition known to Serotonin Syndrome right one key interacting interaction where it can occur is is with Iowa Ska and. And certain antidepressants, yeah, which is a reason that is often stated like you should be very careful if you are engaging in what's called freelance therapeutic psychedelic us well. Yeah, exactly I mean that's one of the things that We alluded to and I. Guess we'll talk about more. Is the episode goes on? Is that even though we've established? PSYCHEDELICS have relatively low recognized risk when compared to many other drugs. It's not impossible for them to. Represent especially when you think about how they may interact with existing psychological conditions or other drugs that you might be taking right so back to Serotonin while Serotonin does seem highly involved in the internal regulation of mood, it's mechanism is somewhat complicated it's also involved in a number of other processes throughout the body and brain that aren't directly related to mood. At least as far as we know, for example digestion, the like the vast majority of the body's Serotonin is found. Found in the gastrointestinal tract, and it has something to do with the regulation of bowel movements. I'm sure some comedian out. There has a great joke about like they're the depression. Slash bowel movements, serotonin thing I don't know. Haven't put it together in my head, but run with it, somebody Serotonin also has a lot of other uses in the body. It apparently somehow seems linked to the regulation of sleep to bone metabolism. So you know like the creation Osteo? Blasts Osteo. OSTEO genesis sexual arousal blood clotting, so there's a lot of stuff going on. And according to the PSYCHEDELIC researcher Robin Elkhart Harris Who's going to show up in research that we we'll talk about later quote, a compelling unified theory of brain serotonin function has not yet been established. This is likely due to the exceptional complexity of the serotonin system with its fourteen plus receptors over twice. The number identified for any of the other major neuro- modular systems, so there are A. A, lot of different, basically holes in the body in the brain for that molecule to put its peg into, and they probably all do slightly different things or maybe largely different things, nevertheless, it is clear that Serotonin play some important role in psychiatric disorders like depression and one recent theory. I thought this is pretty interesting. It's probably not conclusive. We appreciate you don't have a agreed upon theory of Serotonin yet, but one recent theory is that in Carl. Hart Harris's words Serotonin? Are Important for? Mediating an individual's sensitivity to context so serotonin might play this important role in the brain for like increasing the salience of contextual things in the environment interesting, but where to psychedelics come in, so what happens is the classic psychedelics appear to bind to a specific subclass, of Serotonin, receptor known as the Serotonin two, a receptor in these receptors are found concentrated in the human cortex. The CORTEX is the outer layer of the cerebrum brain, which is associated with a lot of higher brain functions like sensations. You know visual Cortex, the auditory CORTEX. It's associated. Centers for speech and language for voluntary action and stuff like that so when you take a psychedelic like LSD or suicide and mushrooms, the active compounds make their way into the brain, and they sort of play act as serotonin binding to these Syra two a receptors. Now because we have such a limited grasp of the role of Serotonin to begin with, we don't fully know how to interpret the Niro. Chemistry here like what's happening with the Serotonin receptors that's associated with or creating the psychedelic experience, but Robin Harris hypothesize. Is something really interesting? The Socar Hurt Harris says that quote Serotonin differentially encodes behavioral and physiological responses to uncertainty so under this model. You'd have like another serotonin receptor at one, the Serotonin one a receptor in car hurts Harris, says quote that provides Basil Control. Control during normal conditions be a moderating emotion and anxiety and promoting a generalized patients, but the two a receptor which psychedelics have these agonists properties for the PSYCHEDELICS SCO in the to a receptor quote is hypothesized to engage more during conditions of crisis when the above mentioned default mechanism becomes sub optimal Eg when an individual's internal and or external mill you become so changeable, indoor, inconsistent with his or her prior beliefs and behaviors that significant revisions become mandated in other words Carl Hart harasses hypothesizing that psychedelics provide a neurochemical. neurochemical hyperstimulation to receptors in the brain that normally work during situations of crisis in change to quote relax prior assumptions or beliefs held at multiple levels of the brain's functional hierarchy, perceptually emotionally cognitively philosophically G. in terms of biases in so doing it opens a door to heightened sensitivity to context an ideal precondition for effective change. So that was really interesting to me like it to be clear. We still don't know of this hypothesis of what's happening is correct but it seems informed by what we do know about. About serotonin receptors in about the Niro Chemistry of psychedelics and I guess the idea is that they sort of mash frantically at buttons in the brain that naturally when pressed caused the brain to break internal habits, associations and traditions at every level from the senses to the beliefs interesting, so in the same way that a basically like a traumatic experience can change or alter our our our preconceptions about the world, or in the same way that glimpsing something marvelous say like seeing the Grand Canyon for the first time might. Have some at least minor change in the way you think about about the natural world like the the psychedelic state is kind of like leaning into those The those kind of experiences though that facilitate change I think that's right. According to this hypothesis, at least in this does seem to ring true to me based on everything else. We add It's Kinda like how I. Think we've talked about this on the show before. How it really seems like it's easier to break habits or make changes in your life while you're on vacation or in in any other kind of doesn't to be just vacation while your external contextual circumstances are different you know you're faced with a different environment different stimuli. Maybe you're meeting different people. You're facing different challenges or problems that seems to give rise to processes in the brain that makes us better at changing what we've done and how we've been before, and it makes sense right, because if we as an organism, we change location we change will. We changed set and setting. You know we we end up having to update our priorities, and our our judgments about where we are, and ultimately who we are and so it seems like under this hypothesis, psychedelics may be doing something like that, but in an even more intense and chemically focused way right and. It's interesting in. In a way that does not necessarily require an experience of trauma, right or or some sort of you know tremendous physical travel well, but there are interesting parallels to trauma I mean again. This is something that's very common in the reports that we've read about with the participants of the Marsh Experiment people very often report having some kind of experience of dying or going through some great trauma during their trip, and yet after their trip on the whole, they report positive effects and. And changes in their mindset in their life so I i. don't think we should necessarily discount the the relationship trauma..

Serotonin Syndrome Hart Harris Robin Harris Robin Elkhart Harris Iowa gastrointestinal tract Marsh Experiment researcher Carl Hart LSD Niro Grand Canyon Basil Control
"serotonin syndrome" Discussed on Limitless Mindset

Limitless Mindset

03:23 min | 2 years ago

"serotonin syndrome" Discussed on Limitless Mindset

"Can always just reach out to me and and I will give you a bit of frank feedback. First of all is five. ht P. This is a commonly sold sold remedy for improving mood or managing symptoms of depression but rigorous research done indicates that it's not a very very good monotherapy four depression. It didn't outperform placebo when used a loan for depression. Russian the real concern with it though is Serotonin Syndrome five. ht spikes the neurotransmitter Serotonin and too much serotonin results in a bunch of nasty symptoms leading up to and possibly including being death. That's right it rare conditions a few capsules of five. HDP is not going to kill you but combining five ht P with other serotonin boosters. Things like Saint. John's Wart Amphetamines Ecstasy. Dec- MD and MBA or some other pharmaceuticals. I linked to a list is risky. There are better solutions for for regulating mood and addressing depression. You WanNa look into on the nutraceutical side. Things like a Rodeo Rodeo is excellent for depression and mood and you WanNa look into things like meditation makes a big difference. I advise passing on five. ht P next risky nutro. BEC- is a draft hill. This nasty tasting drug is is the pharmacological antecedent to modell developed in the nineteen seventies. It's an anti Ayar Drug that doesn't enhance cognition wakefulness and motivation. Nearly as much as would affect does there's also some liver damage risk if you're taking it regularly since it's off patent it's very cheap and for some reason a lot of newer bio hackers order and try it like most things in the nineteen seventies Adra. Fennell belongs things in the dust bin of history. Next risky category really is amphetamines. So this is going to include. Clued things like Ritalin adderall and vivants to keep rowdy kids sedated in painfully boring in public school classrooms. Big Pharma created this category of amphetamine-based h drugs for little ten year old. Tommy Tommy and suzy to take daily amphetamines probably do help. Some struggling with ADHD but doctors. These are way too willing to prescribe them for frustrated parents. But they do have a number of well documented side effects.

depression Serotonin Syndrome Tommy Tommy Big Pharma frank liver damage Dec- MD ADHD adderall Fennell John Adra suzy
"serotonin syndrome" Discussed on Core IM | Internal Medicine Podcast

Core IM | Internal Medicine Podcast

12:21 min | 2 years ago

"serotonin syndrome" Discussed on Core IM | Internal Medicine Podcast

"Productivity developed influence. But sorry can I get it already have to go onto the next okay. So so let's answer some of these questions for you folks so lear first question they ask what medications the patient is currently taking Losarte Kalonzo Ping Haloperidol in the theme. He's also prescribed Hyphen Hydra Ming as needed for sleep. Nothing else next. They asked whether the patient immuno compromised in any way kind of a broad question. Since there are many forms of immuno-compromised. Maybe you should make them atomised. Maybe but you know what you don't say no to your former program director or the Vice Chair for faculty affairs n regardless. The answer was the same across the board no he had a fourth generation. HIV HIV screening tests on admission which was negative. A Hemoglobin A. One C. Measurement confirmed that he wasn't diabetic. He didn't appear severely malnourished. And he wasn't on any immunosuppressants suppressants Or for that matter any other medications aside from what you just said third question. They wanted to know how the patient initially presented to the psychiatric unit as it turns out the patient living homeless shelter in Watson in by staff lear who reported that he was behaving psychotically responding to internal Stimuli Stimuli Garden in electing his self-care however he was not violent or agitated naughty he appeared this dynamic and in terms terms of the time of year. This case occurred in early July in the Northern Hemisphere. So No. This wasn't the flu so this show being called who feeds. We appreciate appreciate the thought. It's interesting I only. Because most psych admissions tend to be fourteen days from insurance perspectives. I no I haven't I I'm curious as to why you want to know how long just to see if it was something they brought in from the outside. Yeah exactly exactly so Sort of this idea of how he presented if he was coming in toxins If he was coming in with the viral encephalitis lightest would anticipate there to be a lot of overlap in that they wouldn't have taken fourteen days for him to present with that. This tie feet report allows us to get rid of the TUCK DOC screen with the exception of the idea that somebody's bringing in something to be toxic curtain withdrawing or something that otherwise The whatever that is eight and nine seventeen days too long too long for a lot of things and I'm very fixing is backed actors medicines again other any meds that were added or changed once he came. Yes no patients hosts V taking to make doc outpatient the positive those medications were resume during hospitalization. But it's unclear what he's actually cheating them okay and when he got into the hospital he was those were reinitiated. That's right and Iran and anything else change from hospital day. Two to the ninth today. I'm sorry in terms of his his meds he helped Heyerdahl added a four two milligrams twice today so the his med list suggests that has underlying thanks psychiatric illness to begin with. And so it's reframed the the way I'm thinking about this now. You know the way I heard the chief complaint in thought of the context of this conversation thought it would be be a primary psychiatric presentation of a disease process that would unify neuropsychiatric symptoms on this high fever. The fact that he comes to his initial presentation on these medicine's suggests that this is a chronic process. And I'm less inclined to tie them together. Okay so just to review So far we have presumably ably immuno competent thirty nine year. Old Man with schizophrenia. In the psych unit started on Clause Opinion Lithium followed by Hal payroll and then a little over two weeks into his hospitalization. He developed this fever and this point they requested a complete blood count on the day of the first fever. Look total white. It's normal five point to forty seven percent. Neutral fills twenty eight percent beams. Sixteen Percent Manos seven percent heels in relative terms Luma. nosing eels are modestly elevated but to save fuel a tropical doing the math. The absolute outcomes are within normal limits. The hemoglobin platelets. Let's our normal our discussions than asked for a hypnotic panel those results. The Trans eminences were slightly elevated. Ast Eighty three eighty four four International units per liter which is a little bit over twice the upper limit of normal These had been normal when last checked on the first day of his hospitalization meanwhile the alkaline fossil tastes and bill. Rubin measurements were both within norms. And this point. They shifted to physical exam. Late asked whether clones US hyper reflects the out or by Therese's wore person finding slough would be system was Serotonin Syndrome. They also asked whether there was any Richard Ity knows were all absent. They also wanted to know more about the pattern of the fever. How high did it reach? And how many days did it last. Well the temperature reached a maximum of a hundred and three point six degrees Fahrenheit and he was persistently Febrile even after seventy two hours. Every single temperature was measured was elevated. Did in spite of repeated doses of I just think that his degree appear exit is unique one hundred three point six is yeah and the acuity of this is also drives me in a particular way. I mean it again like you said. It's against hygenic infections. Also against any one of the sort of more chronic will great TV for example for somebody to suddenly show up with a fever of one hundred three. Have One of these other infections does. It isn't infection but does not causing elevated white count and just that's out there. I mean that's a tunnel syndrome Iraq of cleanliness. It makes less likely so we're at ten questions and at this point Dr Cox asked whether there was a rash and yes there was it was a diffuse eruption of pustules and Papillon's by asking follow up questions are discussing establish at these lesions were scattered across the face. The chest trunk back in arms what the legs seemed relatively spared. There were a few lesions on the palms none on the souls and nothing in the mouth or on the genitals when asked the patient denied that these lesions were particularly particularly painful or periodic in fact he barely seemed to register the presence of the rash at all as he couldn't exactly recall winner where it started for what it's worth notes it's written by the staff psychiatrists earlier that week hadn't mentioned any rash. A Siphon the rush the risk of his physical exam was relatively on remarkable. He had the soft systolic murmur in the pulmonary area. Latina that radiate. The lungs were clear. There was no appreciable he paddled splint or medically or tenderness there were no joint infusions. The prostate was numb tinder on rectal exam. And it's at this point after asking roughly fifteen questions having her her that story that exam and some very basic labs that are discussing proposed the correct diagnosis I have to say I was surprised. They got this so quickly. I had a long list of answers prepared to questions. I thought they were going to ask. What did you think they? We're going to ask. I mean this is just getting back to something you talked about in our last episode. About how expert clinicians often spend a great deal time thinking about who the patient is and what dirt risk for. You know what felt of embarrass called the enabling conditions. So I expected. They'd WanNa know more about who this patient was. We could still run down list in case any of our listeners. A nurse one Lewis Information. Sure Cindy so more about this patient. Well he was born in West Africa. He had emigrated to the United States in his early twenties. Mace and had been living in New York City for the past five years. He said he had not traveled outside of New York City. Within the past six months he was unemployed and as you said Cindy he was living in shelter he had used marijuana before but otherwise denied any substance use. He had not been sexually active within the past year. There was no significant family history He had a father and brothers in Africa who were as far as he knew healthy We also have have some other test results that you folks may or may not be interested in The basic metabolic panel was normal. The urinalysis was normal and cultures. Ultras of urine and blood showed no growth through seventy two hours. His chest X ray was read as clear. The Serum Creatine kinase on the day of his fever was slightly elevated to to eighty three units per liter. This rose over the next forty eight hours to two thousand Before down trending spontaneously thereafter clause subpoena and lithium lithium levels. Were checked on the day of his fever. Those were both within target range as I had said before the HIV screening test was negative he also had an HIV test that was percent and this too was negative The RPR and TPP a essays were both negative and a urine pr for Ghana caucus was negative. And I think for the most part. That's all the data that we had.

Febrile lear US Cindy flu New York City Haloperidol Northern Hemisphere Ghana program director Serotonin Syndrome Heyerdahl Iran Vice Chair Hal Africa Richard Ity Rubin WanNa Lewis Information
"serotonin syndrome" Discussed on Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

05:41 min | 2 years ago

"serotonin syndrome" Discussed on Real Life Pharmacology - Pharmacology Education for Health Care Professionals

"We've we've also got a general materials for clinicians in general so if you're a nurse Practitioner Maybe a MED student physician nurse. We've got Materials they're a just recently reduce released a drug interaction book so Go check that out out cover Easily the top two hundred drugs In that book and point out some of the most common interactions and more importantly really Some questions to help assess those interaction and identify how serious some of those drug interactions are so definitely go check out all those resources. All the links MED DOT com slash store. Okay so let's finish up on. Drug interactions with with DOXA pen. So the biggest one from a metabolism standpoint with Doxa Pin. I think about Cyp two D six. So Docs happen is metabolised by CYP. Duty Six so. If we have an inhibitor or inducer that can alter the concentrations of dachshund specifically some of the most common inhibitors. I see us. be appropriate appropriate on PAROXETINE fluoxetine. Those drugs can inhibit CYP duty six. which is going to lead to hire dachshund concentrations and that potential to run into some of those and I call and I- histamine type adverse effects? Now there are a few other drug interactions besides sip. Twenty six that I wanNA mention Serotonin Syndrome. I kind of talked about that already. additive effects with assessor is You know maybe a Traumat- all all those type of medications that have Serotonin SEROTONIN IRGC activity. Docs pin could add to that. So something that you know. We keep an eye out for and obviously recognize if patients are on higher higher doses of some of those serta energy. Drugs Docs happen. Could increase that risk for Serotonin Syndrome antics synergic additive effects. So I think of you know some of your over the counter antihistamines. Maybe a situation where a patient pick something up over the counter. Maybe they start. Taking docs happen they say. Hey this isn't you know working really well or I needed to work a little bit better. So now they start taking over the counter sleep agent you know a UNISOM of Benadryl diphenhydramine to Kinda add to that insomnia Benefit or that. You know sleep tape effect while we're also doubling up on those annacone urge effect so your your confusion your Dry mouth dry eyes. Those can all all be added on top of. What docs happen already? Does their sedation. So sedative effect You know not just from an anti cholinergic antihistamine perspective. But if we've got other sedative so you know a transit on board if we've got Benzoate as subpoenaed board opioids onboard that in combination with oxygen. Could kind of exacerbate that sensitive type of fact. So what you might WanNa to do in that situation is obviously be more conservative maybe with dosing and or reduce some of the other agents that that may be sedative for adding this on board When you're adding any new medication for insomnia I strongly encourage you to take a look at that medication regimen in make sure that patients aren't already on something for insomnia? This is one of the areas of Poly Pharmacy that I see all the time time. So patients search taking Melatonin over the counter Then you know doesn't work for them. So maybe they are doesn't work very well. So then they reported to their the primary care provider. Their primary care provider adds something They come back months later. I'm I'm still struggling with sleep. You know that that type of thing and then we get a new medication or a different medication on board or they go. Try another over. The counter supplement or medication K.. So this is really an area where we can Pay attention make sure. Patients are taking multiple multiple medications for insomnia because that definitely gently happens out in practice at something. I see on a pretty regular basis more often than I would certainly like to see it so definitely pay attention to that adverse effect in that risk for drug interactions and accumulative type effect. And then one last one cutie see. Prolongation is a potential hinshaw concern with Docs pin. And it's obviously going to be more concerning. If we add it on board to other drugs that can add to that effect mcteer anti arrhythmic like Ami Odor Own Your QVC prolonging anti psychotics for example. So there's lots of different medications that could prolong the interval But that's definitely a risk assessment That you need to think about it and talk about and I do talk about some of those cases and Kinda my strategy and approach in dealing with some of those cases In my new book Clinicians Guide to Common Drug interactions in primary care hair..

Serotonin Syndrome insomnia IRGC I hinshaw Poly Pharmacy histamine PAROXETINE diphenhydramine Melatonin fluoxetine
"serotonin syndrome" Discussed on Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

06:59 min | 2 years ago

"serotonin syndrome" Discussed on Real Life Pharmacology - Pharmacology Education for Health Care Professionals

"Admitted one dot com slash store when that's out in around the first of January in twenty twenty is my goal so By the end of January two thousand twenty that drug interaction book should be out anyway. Let's get into the Drug we're going to talk about today. And that is flu oxygen so I went into a general overview view regarding Selective Serotonin reuptake inhibitors. You can go back Get a little bit more broad view of This class of medication in general if you like I wanted to Break these down further because there are differences when we're determining whether we're going to select one s assessor I vs and other so I wanNA highlight some of those differences Today for sure so SSI obviously it can increase. It's basically the effects of Serotonin within the brain Which helps manage depression anxiety These drugs have been shown to would be helpful in OCD PTSD Some eating disorders as well. So lots of potential clinical uses which is why you see flu oxygen and a lot of the other SRA's so frequently and in practice of course the box warning is is a class effects increased risk of suicidal thinking and behavior That boxed warning does remain in effect there adverse drug reactions Again kind of across the board with us. Rise you've got sexual dysfunction that Serotonin Syndrome risk Again extremely low does not happen in practice. Hardly ever I mean I've only seen or heard of really a couple of cases Not that it isn't something we shouldn't pay attention to or or be on the lookout for but again just in in context it is extremely rare or not something that you're you're gonNA see on a weekly basis or monthly or or anything like that. It's it's less common than that In most situations I flew oxygen specifically I J upset nausea that that can happen With this one certainly intends to have a little bit more more of that Jay upset and more specifically diarrhea. Maybe than than fluoxetine does One unique thing about flu oxygen unit amongst long-sought. Assessor is I would say it tends to be a little bit more on the activating side. So if you've got a patient that struggles as with insomnia already. We might lean away from fluoxetine in favor of another Antidepressants or another. Sri Can dosage forms. So here's a unique thing with flu. Oxygen there actually used to be. I believe it's been discontinued now. I I haven't seen it in in years But there used to be a once. Weekly dose for Fluoxetine. Okay and and one of the reasons that they could get away with. This didn't really gain much in in popularity. I don't think I don't recall it ever gaining much Use The reason can have a once weekly dose is because the half life of flu. Oxygen is significantly long. Okay Eh so that is different from a lot of the other. Assessor is and it has the longest half life of all esser is so that allows us to potentially dose this less frequently so the patient misses a dose of fluoxetine. which certainly can't happen in real life? it is less likely to kind of interrupt their concentrations and their levels as much as you you know missing a dose of a shorter acting agent Maybe like PAROXETINE for example. Okay so that's one important point regarding the pharmacokinetics Alex and the longer half life of fluoxetine. Another situation where this may impact our patients is if we're tapering down owner tapering off of Sri so again. Let's take paroxetine. As as a potential example. Here proxy team has a shorter half life life compared to flow oxygen with a really long half life. When you've got a really long half life you tend to have more of a self tapering ring type effect because those blood concentrations drop more slowly because of a longer half life so what this means means in clinical practice is you potentially could be a little bit more aggressive with tapering down? Enough Loook. Sixteen then you would with paroxetine. Potentially because it has that flew oxygen has that self tapering Type effect and in the setting of we abruptly discontinue a medication to quickly. We can run into discontinuation syndrome with with Basically any of the Esser is so again. fluoxetine might help To kinda minimize that that discontinuation syndrome You know Kinda those. Those withdrawal symptoms of of the drug people can be anxious nauseous Those are two prominent symptoms of kind. Hannah this disconnect Discontinuation Syndrome pharmacokinetics wise. Another really important thing with flu. oxygene is It is primarily broken down by CYP Tutti six so in Pharmacogenomics We think about this enzyme breaking down the drug it. We've got patients that are slow metabolisers at the enzyme. Cyp Two D six. They are more likely to experience higher concentrations and more effects potentially high-risk toxicity with flu oxygen. If they are a rapid metabolize her we would likely Not See a benefit or less likely to see a benefit because the body is naturally chewing up that drug much quicker and deactivating it In a much quicker fashion if they are a rapid metabolize sugar at CYP two D six..

flu fluoxetine PAROXETINE Serotonin Syndrome esser CYP Tutti OCD nausea Hannah Pharmacogenomics Jay flu. Alex
"serotonin syndrome" Discussed on Oregon Rooted: The Dirt Show

Oregon Rooted: The Dirt Show

11:43 min | 2 years ago

"serotonin syndrome" Discussed on Oregon Rooted: The Dirt Show

"Be like. Hey Bro Oh you ready has this This really cool story and I actually wore the shirt today from a music festival. I like it man. I did picture that says Brownies. Says don't blame it on the I. Aw Ten Sleep Wyoming Za Music Festival out there and invited to go. I brought a bond verb this summer. I and it was hot and it was so hot out there and I ended up making these brownies. Out of an ounce you know just in a in a camper right there at the campground right down the road from the music festival and I was telling everyone I was like Oh man you know. I'm Kinda scared to those house. I would need more than like an inch an inch square while Later that day turns out. The people enjoyed the brownies so much they they more and more in a few people. Well we're talking about that neighbor. I have that she makes the positive Tori. I'm interested. You gotta be careful man because as stuff kicks in like ten minutes and you can easily overdo it. The problem is I think is that people don't have unless it's tested cannabis. You don't know really. What the percentages you can guess right but you know what you guess might be you? You don't WanNa Guess Hi you're like this can't be that good it's not twenty percent will say it's seventeen and really it's twenty two or some shit you break it down and stick it up your but if think it's GonNa you know you don't know right so she says she's ran into some problems. He went to the hospital three times knowing that she's going going to overdose but that she was that uncomfortable. I wonder if he was racy or she was just like. I didn't go any I don't know. But she said that She filed the she filed a formal complaint because one of the time she went in they they told her. There's nothing they can do for that. It was just cannabis and there's nothing nothing you can do Bullshit anyway. She complained the fuck they took her in and took care of her. There's nothing you can do though because a little dehydrated got an extra bag of sailing. Well that's what I'm saying. I might get probably mental for her. You know right and you know. Obviously they can do things you know cater cater to you or whatever but do you just have to ride it out. lay down in bed. Throw some covers over here you know. Turn the light out. Eat some ice cream. Take a shower that works for me. Yeah Ler long bath. That's the other thing. suppositories are potent. Also bath bombs. I have a lady that makes bath bombs out of roots. Now listen to this man. They're monitor beans and Dieter Pins in roots that are not found in the actual plant with. That said there's a lady that we Bhai bath bombs from very expensive twenty five thirty bucks a piece but she uses the concentrate from the roots. No kidding I'm GonNa send you home with one brother. No kid you take one bath in that. That's it and it's hard to step out like this. You want to make sure you're holding onto something. Does she ship I'm sure she does But it's interesting to say the least what I don't know what's going on in there. I don't know what action is going on. I don't believe there's teach in the roots it's If there is probably not much but I'll tell ya Whatever those turbines are compounds are in there? It absorbs I mean. Is that no no time it. Yeah it's it's yeah like when like that time of the month for my wife one of those bombs in their bloom dosed done but we'll send you with one of those so it's interesting to think that you know these types of products that we can explore them really changes things up and makes it even that much more potent I suppose. Well what do you think for the future. You know even All of these spreading projects in everything and even inbreeding you know like cheese family came from skunk that was inbred right right And I could see that happening. What other compounds are can we actually create new compounds? Sounds through breeding Stuff like thanks I think about you know and I only there's these big kick now CB or CBGB's CBS wins. Wins and I believe in CBN. Yeah well I mean. I think we're going to run the gamut with the boys. I think that we're going to exploit each one for what we can for sure I definitely like the CBN the non-australians man Something you smoke and you're going to bed I I'm a big Fan. Yeah Yeah for sure. A A lot of people are especially old school guys right on because that's what you're looking for back in the day I don- yeah. Yeah that's it but yeah. These guys are using breeding techniques to pull those out and raise those numbers so live like I said. I think that's kind of the future we're going to exploit every turpin and every cannabinoid to the fullest could see down the road where we're going to be like well I'm going to have a C.. BGN OR STRAIN CBD strain. I'm going to have a TC strain a and have a whatever strain you know. Sure but I was going to. Who's going to back by science and be fair with WHO's GonNa who's doing it to to know oh l. man? Why appreciate sit down with us like this man? Thank you for having me. It's all the way Colorado. It's fun it's fun to talk to you guys and you have your first interview in the studio. Yeah Oh man I that is amazing. It's a great studio here. You just don't tell about the mess. Uc Right now. You get to see the mess before all look pretty. This table is clean. Clean Clean Glass. Yeah never And we've got a few editions T in a mood. Man That's cool. Hey right I noticed. Issue like mine and I was determined to get you the same one couple more legitimate mouths if anybody hasn't seen him at Matt's man Mood Food Mats and those came from positive vibes down in Inglewood. What's up boys Colorado? Yeah shout out to you guys are going to be in the studio now. So that's cool. But they're legit like most people allies talking. You use those damn mouse pads. Yeah man those things filed a slider and gear get stuck all. Oh Yeah Massey But yeah the mood master. USA made fricken. This is even advertisement. I just think they're cool shit recycled material. They don't my DAB My rigs don't flat around actually. We're going to use this one for the nicer exit. Come in through Walmart Dude. It is a nice one and on mushrooms at no doubt that yellows vivid very remember you. You can get Sarah toasts are Serotonin. What cert- cert- Serotonin Syndrome is what it's called you can get Serotonin Syndrome from eating mushrooms? which causes what which starts to Numb the receptors rain? And they're blocked so man that's GonNa not be good. You can essentially wake up vegetable on mushrooms. I should think I mean your feelings right. They would just not be there right right right. I'm sure you can screw yourself on a lot of things especially if you're inclined to through it but what does it say man high body temperature agitation increased reflexes tremor sweating dilated peoples diarrhea. Yeah I get that with my First Cup of coffee man come on okay so so acute serotonin syndrome or long-term effects of it so use it. It is a different tool than the concentrate. I imagine you use it to if you want to get to that Eddie state right. I'm I'm I'm more of an organic sky like my flower. I like my joints. I like to the eat fresh. He's I like to eat dry dragon or so with fresh mushrooms. Man Can mushrooms uptake. Things that might be you know not good for you. I mean cannabis cannabis sequestered heavy metals. Such from soil. Fungus is a very very weird thing that we really don't know all that much about Top my colleges in the country these are studies it. I think are yet to be done but absolutely my belief. If is anything that comes from the soil can take from the soil. So I mean you know growing your own. Mushrooms is probably a good idea that if you if you want to have the best product. I'm very interested in this. I'M GONNA I'M GONNA look more into this This is something. I'd like to know more about but my assumption is yes you ha- you would like likewise. want to grow organically with mushrooms as possible. In what chemical would you know. What what synthetics would Let's say like A. PG are area's cannabis. What would that be to mushroom right? I don't know you already grown fatty mushrooms man. God I hope I don't have any. PDR's in there. I know what AH coffee grounds fucking. PDR's right there folger's no wonder you get Serotonin Syndrome. He's dose in the mushrooms themselves L.. Straight with coffee men so Yeah listing tinkerbell other than size is though like on those bigs mushrooms. Do they really does it really matter or is it just a kind of a trophy thing I didn't ask for it. Just became an and it's ask statically pleasing thing to me. Yeah I I like it. Yeah I like to try and beat the last wet way on the motion I get that but ultimately it's just it's the same as anything else in their own right and it's GonNa have the same effect as a small guy and you know a lot of people would tell you that the smaller winds actually have a little more of the the stuff you want in a man I tend to agree. I like Like a smaller mushroom But it is fun to too much down twelve grand mushroom the apple. Just what's your what's the deal on this. So people say that stems are different. High than the caps the caps the caps have it all is. Are you talking to Silla Sivan part correct. The cavs tend to have a little more potency. Okay and Yeah Ah I've tested this and I I would definitely agree. that an eighth of caps is a little better than an eighth of stems. All right. It's been decided I've wondered that for probably the last twenty five years of my life because I've been told that since the beginning and I've never you know done any official testing myself. I just eat that whole damn bag but well the first boxer you're gonNA check as it's easier to chew and put down yes it is the first check those stems man. It's like chewing on celery. I mean leather leather celery. Manet's Sir just pick it fresh. Get Sal ranch baby ranch some some of that blue cheese sauce or some No I don't. I would think that I would like fresh mushrooms better. Although there's just more to eat like you'd have them more that you're like chewing down. It's so easy they're so good had just. Can you take your mouth get blue from that shit now. No I haven't seen that now. Well the you know how. It's the blue not immediately if you eat enough of them. Yeah I sure could get blue.

cannabis Serotonin Syndrome Colorado Wyoming Za Music Festival cert- cert- Serotonin Syndrome Tori cavs CBS Uc PDR Dieter Pins CBN USA turpin Manet Silla Sivan official Walmart Inglewood
"serotonin syndrome" Discussed on Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

08:04 min | 2 years ago

"serotonin syndrome" Discussed on Real Life Pharmacology - Pharmacology Education for Health Care Professionals

"Brand name of this medication. Izzo Fran this might medication is primarily used to help manage help prevent symptoms of nausea and vomiting and with that it that nausea vomiting could be due to a variety of reasons so one of the most common medication induced Ah Nausea and vomiting situations with chemotherapy so we may use it in that setting particularly with agents that have high. I met a genetic potential. there may be various disease processes so in in my practice mostly in geriatrics geriatrics experience in geriatrics. You may see hospice patients on this medication that maybe through their disease process or something. They're they're having thing some some nausea and vomiting. another good example of a situation is Gastro Aparicio's from patients with with diabetes that may run into that issue there. I have seen on dance a Toronto used in that situation but I as a clinical pharmacists I I think about nausea and vomiting and when I see nausea and vomiting it immediately makes me think of of medications and you really gotta look out for Zoll friend when you see it as being one of those trigger type medications as Managing Zhang or potentially masking a side effect of another medication so some great examples of you know somewhat common medications that are we used out there so the gop ones so these are your Victoria's by Atas. things a true listen these things of those nature. I was those medications can cause a significant amount of of nausea and stomach upset so keep an eye out for those metformin foreman can cause some. Gi upset certainly did Jackson toxicity. CEO Cohen inhibitors in dementia. opioids kids can sometimes especially initially caused some some stomach upset and things drugs with dopamine agonists activity. I think of managing Parkinson's disease and if we get too much cinema we might run into some of that nausea vomiting antibiotics of course incredibly common cause of of stomach upset nausea insects as well other common example that I have seen cause some issues there so definitely look out for those trigger medications that we might be using on dance at Tron for economically so this is a selective five. Ht Three receptor antagonists essentially blocks serotonin cernan activity within the Chemo receptor trigger zone sometimes referred to as C. T. Z. And and this area is basically found in the brain specifically I believe the MINU Law Bogata but with that that's that's kind of the the Central Area Region that we've we've found researchers found to be the Control Center for Nausea in writing basically akin be triggered by substances substrates in the blood that run through that area that the body may trigger as you know poisonous or toxic and and we want to get rid of those in a very quick fashion there so that's where the the drug acts potentially there now. If you remember in the Z. There are other neural transmitters editors in play and dopamine is a big one there which I'm not going to talk about on this podcast much but if you remember some of our dopamine blocking type agents agents can be used to help manage nausea and vomiting as well. They're adverse effect profile. Usually it's thoroughly well tolerated from from what I've seen in in practice I would say probably some. CNS changes are going to be of the most common in within the adverse effect profile. Heresy May see some a drowsiness sedation type of facts. maybe dizziness maybe headache things of that nature but there's two specifically that I did want to mention that definitely do come up again very very rare these two do but some certainly something to think about so the first one cutesy prolongation and I'll talk a little bit about that in drug interactions thinking about other medications and risk factors as far as non medication risk factors that you've got to think about when we're talking about. ekg changes and that risk of tour sods due to cutie prolongation so low magnesium low potassium if a patient patient has a lot of pre existing heart issues that might be a patient at risk there as well and then certainly those those medications which all cover and Drug Interactions Serotonin Syndrome was the other rare but obviously serious potential potentially reported issue with these medications and particularly you think of other meds that would exacerbate eight that that Serotonin type of fact I have seen conflicting evidence on this so the FDA they've they've come out and Said said you know we've received reports on Serotonin Syndrome with on dance tron particularly maybe on patients on some of those other medications ends which all uncover and then. I I did see a review article that that says you know this isn't an issue and or there really isn't any true mechanistic way that we can hypothesize that there should be an issue because if you think think about it where blocking Serotonin so it should in theory depending upon the receptor have locking type of facts not additional serotonin too much serotonin activity so that one's still kind of up in the air for me. I guess as far as what do you do in in clinical practice. I have seen drug interaction flags. Come up for this and if somebody's on let's say Sir trillion or assessor I with that said I I certainly look at it. I think about it and Kinda way it on an individual basis risk-benefit type of assessment there so yeah. Hopefully we get some more research on this. I've I've seen a potentially both ways where some say yes. This is absolutely an issue and other research may be saying yeah. Maybe it's not really that big a deal so I would keep your eyes out in the future and see if we can figure out more info on that and help you know kind of settle how big of a deal if it is a big deal. Let's take a quick break from our sponsor and we will cover drug interactions when we get back if you're in the market for test prep material NAP plex P. S. B. C. ACP geriatric Afric exam pharmacotherapy or the medication therapy management certification which is a newer.

nausea Serotonin Syndrome dopamine Fran Toronto Gastro Aparicio diabetes Jackson Chemo Parkinson metformin CEO foreman Victoria Zoll gop Zhang P. S. B. C. Cohen
"serotonin syndrome" Discussed on Pet Life Radio

Pet Life Radio

12:07 min | 3 years ago

"serotonin syndrome" Discussed on Pet Life Radio

"You'll find us you will find this. Sometimes I get updates from some of the platforms that were on. Oh, yeah. Run that platform completely forgot because of that many of them, but no excuse not to listen to us, and you can listen to his anywhere in the world talking of in the world, Jim. You know, we have supporters from all over the world all over all of the world to charity events. We've got friends. It would businesses all over the world that supporters, and I'm in a group of people who have pet businesses and it's bit group and some really fantastic pet businesses. And I, you know, I have a hard time with groups is not really knowing what their rules and regulations are a can't keep going back to the nose candidate is kind of post that up close. Constand? I'll be honest with you. Anyway, I did ask a couple of days ago was okay for me to pose my charity event because we're looking for responses and people would like to donate. Now. Of course, this isn't a group of businesses, and I'm doing charity event golf tournament for animal rescue, and there was told no they don't they don't don't do local. But the thing is we're not local anymore. Knowing that company. Yeah. Now, you don't know who it was. I thought you'd that was when you told me about the other day now. Oh, no. It was. Yeah. It was the thing is is we're not local anymore. It's a little bit shortsighted. We are not local anymore. I don't care where you are in the world people get to hear about what you're doing. They like to support you. And so that's a shame. Shame. I do think that there would have been a couple of businesses that would may have enjoyed putting business cards and flyers and maybe samples of their products in bags because people by on the internet from all over the world. So yeah, a little bit disappointed in that. Well, but let me tell you something we never struggle for great support. And it's all coming together. So February running around this week. I have to say still got a lot more work to do this weekend. Now, there is say he'll sleep when you're dead. Well, you go through when you put on an event you go through a transformation a bit like the the it gets into a hyper drive mode. Does be preparation. Does. You start to run out of time. You feel like you're running out of time. I don't care. You can give yourself a year. You can give yourself six months. The taxes this year. Got a year to do it people. What we do this week? It was. We were nose to the grindstone you'll still especially events. Because the thing is you will always you'll you'll use every little bit of time if possibly got and if you feel that you've got extra time, you'll just add more elements to it. You'll still run around to get more sponsors more ticket sales. So it's just a lot of work and these faces it goes through all really excited. Yay. Yeah. Me save the date old avenue this day. This is my new Yay. Overlook responses as the next thing, you know, it's. Why why did I say yes to this? I'm only I'm getting into that face. It's every time. Then then once you paid your Bill is we like to say because it's like paying for a wedding when you do a golf tournament. So the money goes down. And then then the goal is to cover that. And once that's covered then like, oh can relax a little bit and keep pushing for your tickets. And and then you have a great time you run around all day yet. She feel that you'd never participated in your own event. And you didn't eat anything, and you didn't have a drink everyday great time, and then we put voters gathering and thank you video. And then we just all over again. We just do all over again can either a little bit more in my headphones. Jim. Sure. Thank you. Just a little bit more. If you don't mind. Oh, that's better way better. Okay. So let's start the show with a tip. This is a good tip for traveling. All right now. People having to flee where they live to get away from hurricane Irma right now. Speaking of our friends and business around the world, we do have friends in Florida. So yes, we do. Yes. We do. I know that they're going to be they don't I don't think they've accumulated at two of my friends actually out that one of them from where I grew up back home in England is out there. But I don't think they have to evacuate with is still after prepare to be safe. And that's important. So here's a tip this tip complex anybody's traveling with pets, and maybe one you've never thought of. But as much as we'd like to then go hotels have been thoroughly vacuumed. I never do. You never know what can lurking under the bed and tables and the chairs and when you arrive in your room before you pick decides to explore you should look into the furniture to see. There are any pills. The pills have dropped under the furniture and not been vacuumed up. Could be over the counter medicine. It could be it could be a prescribed medicine medicine, and both are very very dangerous Chia pets, and that's one of the top reasons is the top reason. Why pets get poisoned is medications? So when you go, and you travel, don't let them off the leash. You have a good old scouts around to one of your wait at the door. Have a good look make sure there's no medicines any kind under the under the furniture because that would be tragic. And might not even know if they've scooped up something that was under the bed. I mean, you know, I don't they will lick that up and it begun. And so I thought I'd then followed this with the top ten Doug poisons. And as I say that number one poison is prescription medication for people drugs that might be beneficial or even life saving for people supplies to some people too, though, doesn't it all this list is probably equally as warning to for people and kids. Oh, gosh. Yes. Yeah. Absolutely. Absolutely. I'm sure is the number one thing especially with children. So here we go. Here we go. And this is many many many medications can have the opposite effect impacts than it has with people. And it doesn't always take a large dose to Demet damage as in dog poison number one prescription medication for people. Some of the most common and harmful medications that poison dogs include prescription anti-inflammatory and pain medications can cause stomach and intestinal ulcers. Kidney failure. And this is this is on this subject. Never medicate your pets with human medication. I saw it yesterday. Someone recommended it to someone else's dog. I said you need to stop that. That's such the most dangerous advice I ever seen. It was so upsetting. Wow. I I was gonna do a show wasn't eye on people with Remm their own dangerous remedies home remedy dangerous home remedies because there are some home remedies very good and safe for your pets. But you've got to know your neighbors have a vet that says, this is okay to do it antidepressants can cause vomiting and serotonin syndrome, which is a dangerous condition raises the temperature in the heart rate and blood pressure, and it may cause seizures and blood pressure medications. So yeah, when you travel with your pet look under the furniture number two, what number two is number two for drugs now. Number two top poison in poisoning dogs. Why Doug show up the veteran vetinarians office? Chocolate. No, it's not that. Again. The insecticides is number two. Oh, yeah. Flea and tick products, you see I bet you anything when I said that you oh gosh. Yeah. What's been sprayed on my garden? What's been put on your pets is the number to poison the number to poison flea tick products? You may think you're doing Doug a favor on your plight. These products marketed to fight fleas and text, but thousands of animals are intentionally unintentionally poisoned by these products every single year. Yes, you are putting an insecticide on your pets and this problems can occur. If dogs accidentally ingest these products as well or if your dogs received small excessive amounts now, this is orally. But I also there is a warning to this that's Lee intake product, you actually, put on their skin is an insecticide. So you need to find yourself a different products and the one I'm going to recommend is one decide we talked about one decide didn't we we did it's all natural lots of these latex products. They they burn skins. They cause seizures. If you've seen the videos is heartbreaking. I mean, really heartbreaking. So be very. The top of the show as tons of questions yourself is this toxic is safe. Day growing up. We put those on our dog. We didn't know I know it's terrible. Oh, so terrible. The risks of what they would get from ticks and fleas was greater than the when what we didn't know about the products. What you mean? The products are more dangerous than the tech. We didn't know the danger of the products, but we knew the danger of the season. And so you lived with the risk. Thank you, just ask questions. It's a thing. You think you're going to do for your pet you someone's you questions, and you will come up with answers, you'll either. No, it's good. It's bad or you won't know. And then you have to do a little bit of research, but one decide is one of those products that is they they have I think they do three different types of products. They do pest control products unnatural which talks about in the previous show, you can catch that items. They do the flea and tick again, it's saying natural really shouldn't say the word natural because chrysanthemum flowers are used in your traditional pest control. And that is what is toxic to your pets. So I'm going to say safe products that you can read the nontoxic. I think that's the important thing. I think they do cleaning products. Can you check that for me? Jim. So there you go number two chrysanthemum. Yes, sir. Tara. No, no, no, one decide if they do cleaning products number three is over the counter medications as I mentioned at the top of the show, and that that means you're Tylenol G. I pro fans Advil Aleves as well as herbal and nutraceutical products and nutraceutical new fish oil joint supplements. So supplementation number four medications just as we can Pacific and by or killed by medications intended to help us cases of poisoning by veterinary drugs are not uncommon either. Some of the most common reports of problems of medications that include painkillers and de wormers. There was a. Medication pet medication company mislabeled drugs a couple of weeks ago for it to be much higher dosage than it should be for the pet. So that was scary. When that came out of household products from cleaners to file auxiliary never thought about file logs. I one file in our fire pick of of years ago. And it was so toxic smelling. It was disgusting. And I realize it's Goto real would. I didn't think about that. But yes, my own experience was that was horrific just as clean as like bleach. Completion people. They're also leading cause of poisoning resulting in stomach and respiratory problems. And not surprisingly chemicals contending antifreeze paint, thinner chemicals. Pulls. Yep. Also can act his dog poison and the pet poisoning system that may produce include stomach upset depression, chemical, burns, renal failure and death. Oh, gosh..

Jim Doug hurricane Irma Florida England Advil Remm painkillers Chia vomiting serotonin syndrome six months
"serotonin syndrome" Discussed on Pet Life Radio

Pet Life Radio

12:07 min | 3 years ago

"serotonin syndrome" Discussed on Pet Life Radio

"You'll find us you will find this. Sometimes I get updates from some of the platforms that were on. Oh, yeah. On that platform, completely because of that many of them no excuse not to listen to us, and you can listen to his any way in the world token of in the world, Jim. You know, we have supporters from all over the world all over all over the world told to charity events, we've got friends would businesses all over the world supporters, and I'm in a group of people who have pet businesses and it's bit group some really fantastic pet businesses. And I, you know, I I have a hard time with groups is not really knowing what the rules and regulations account keep going back to the nose candidate is kind of post that coming up. Plus can't stand it. I'll be honest with you. Anyway, I did ask a couple of days ago was okay for me to pose my charity event, these responses and people would like to donate. Now. Of course, this isn't a group of businesses, and I'm doing charity event golf tournament full animal rescue and was told no they don't they said, they don't don't do local. But the thing is we're not local anymore. Ali. Yeah. Yeah. That company. Yeah. No. You don't know who it was. I thought that was when you told me about the other day. Oh, no. It was it was the thing is we're not local anymore. It's a little bit shortsighted. We are not local anymore. I don't care where you are on the world people get to hear about what you're doing the light to support you. And so that's a shame. Shame. I do think that there would have been a couple of businesses that would may have enjoyed putting business cards and flyers and maybe samples of their products in bags because people by on the internet from all over the world. So yeah. A little bit disappointed in that. Well, but let me tell you something we never struggle that great support, and it's all coming together. So the Feb running around this week. I have to say still got a lot more work to do this weekend. Now, they to say he'll sleep when you're dead. Well, you go through when you put on an event you go through a transformation a bit like the it gets into a, hyper drive mode preparation does. Because you start to run out today for late you running out of time. I don't care. You can give yourself a year. You can give yourself six months. It's like goes with that taxes this year. You gotta do it people. This week. We were we were we were to the grindstone you'll still especially events because the thing is you will always you'll you'll use every little bit of time if possibly got and if you feel that you've got extra time, you'll just add more elements to it you'll still around to get more sponsors Momo ticket sales. So it's just a lot of work. And these are the faces that goes through really excited. Hey, hey, hippy saved the date. Oh, look every avenue this day. This is overlooked responses. Is it the next thing? You know, why? Why did I say yes to this? I'm getting into that face. It's every time. Then then once you paid your Bill is we like to say it's like paying for a wedding when you do golf tournaments and the money goes down. And then then the goal is to cover that. And once that's covered. Oh, can relax a little bit. Keep pushing you tickets. And and then you have a great time you run around all day. A yet she feel that you'd have a participated in your own event, and you didn't eat anything, and you didn't have a drink every time. And then we put votes his cousin vis danke video. And then we just all over again. Just do all over again can either a little bit more in my headphones. Jim. Sure. Thank you. Just a little bit more. If you don't mind. Oh, that's better way better. Okay. So let's stop the show with a tip. This is good tips for traveling. All right now. People having to flee where they live to get away from hurricane Irma right now. Speaking of our friends in business around the world, we do have friends in Florida. So yes, we do. Yes. We do not think that the going to be they don't I don't think they've activated two of my friends actually out that one of them from where I grew up back home in England is out there. I don't think they have to evacuate with is still after prepare to be safe. That's important. So he's tip and this complex anybody who's traveling with the pets and maybe one gift ever thought of. But as much as we'd like to think, oh hotels have been thoroughly vacuumed. I never do. You never know what can be looking under the bed and tables and the chairs and when you arrive in your room before you pet decides to explore you should look into the furniture to see through any pills. The see if any pills have dropped under the furniture, not been vacuumed up. Could be over the counter medicine. It could be it could be a prescribed Mondays medicine and both are very very dangerous to your pets. And that's one of the top reasons is the top reason. Why pets get poisoned is medications? So when you go, and you travel, don't let them off the leash as you have a good old scattered around to one of your way to the dole have a good look, make sure there's no medicines of any kind under the under the furniture because that would be Roger. And you might not even know if they've scooped up something that was under the bed. I mean, you know, infested adults they will lick that up and it be gone. And so I thought then, you know, follow this on with the top ten Doug Pleasence. And as I say that number one poison is prescription medication. The people drugs that might be beneficial or even life saving people's supplies to some people too, though, doesn't it all the this list is probably equally as warning to for people and kids. Oh, gosh. Yes. Yeah. Absolutely. Absolutely. I'm sure is the number one thing especially with children. So here we go. Here we go. And this is many many many medications can have the opposite effect impacts than what it has the people. And it doesn't always take a large dose to Demet damage, and as in Doug poison number one prescription medication for people some of the most common and harmful medications that poison Doug's include prescription anti-flemish story and pain medications can close stomach and intestinal ulcers. Kidney failure. And this is this is while we're on the subject the medicate, you'll pets with human medication. I saw it yesterday. Someone recommended it to someone else's dog. I said you need to stop that. That's such the most dangerous advice I ever seen. It was so upsetting. Wow. I I was going to do a show wasn't eye on people with their own dangerous remedies home remedy the dangerous home remedies because there are some home remedies. Very good and safe has got to know your neighbors have a vet that says this is okay to do. It antidepressants can close vomiting and serotonin syndrome, which is a dangerous condition raises the temperature in the heart rate and blood pressure, and it may cause seizures and blood pressure medications. So yeah, when you travel with your pet look under the furniture number two have you what number two is Jim number two for drugs now number two top poison in poisoning dogs by Doug show for the veterinary office. Chocolate. No, it's not that. But again, the insecticides is number two. Oh, yeah. Flea and tick products, you see anything when I said that you thought oh gosh. Yeah. What's been sprayed on my garden? What's been put on your pets is the number to poison the number to poison flea and tick products, you may think doing Doug a favor when you're ply these products marketed to fight fleas and takes but thousands of animals are intentionally unintentionally poisoned by these products every single year. Yes, you are putting an insecticide on your pets and these problems can occur. If dogs accidentally ingest these products as well, or if your dogs receive small excessive amounts now, this is all really, but I also there is a warning to this Lee intake product, you put on their skin is an insecticide. So you need to find yourself a different products and the one I'm going to recommend as one decide we talked about one decide didn't we we did. It's all natural lost of these flea ticks tick products. They they burn skins. They close seizures. Oh seen the videos is heartbreaking. I mean, really heartbreaking very. The top of the show as tons of questions yourself is this toxic. It's a safe. The day grown up. We put those on our dog. We didn't know now it's. Oh, so terrible. And then the risks of what they would get from takes and flees was greater than when what we didn't know about the products. What you mean? You mean, the products are more dangerous than the tech? We didn't know the danger of the products, but we knew the danger of the the tick. So you lived with the risk. Thank you, just ask questions. If you think you think you're going to do for your pet, you sesame bunch of questions, and you will come up with answers, you'll either. No, it's good. It's bad. Oh, you won't know. And then you have to do a little bit of research, but one decide is one of those products that is they they have I think they do three different types of products. They do pest control products unnatural, which talks about in the previous show. You can catch that they do the flea. And tick again, it's saying natural. I really shouldn't say the word natural because chrysanthemum flowers a used in your traditional pest control. And that is why is toxic to your pets. So I'm going to say safe products that you can read the nontoxic. I think that's the important thing. I think they do cleaning products. Can you check that for me? Jim. So there you go. That's number two. Yes, terra. No, no, no, one decide if they do cleaning products. Number three is over the cans medications as I mentioned at the top of the show, and that that means you're Tylenol ibuprofen, Advil Aleves as well as herbal and nutraceutical products in nutraceutical new fish oil joint supplements supplementation number four medications, just as we can. And by all killed by medications intended to help us cases of poisoning by veterinary drugs, not uncommon either. Some of the most common reports of problems and medications that include painkillers and de worming. There was a. Medication pet medication company who would mislabeled drugs a couple of weeks ago for it to be much higher dosage than it should be for the pet. So that was scary. When that came out five household products from cleaners to file eggs never thought about file logs. I one file in our fire pit couple of years ago. And it was so toxic smell in. It was disgusting. And I realized that needs Goto real would I didn't think about that. But yes, my own experience was that was horrific just as clean as like bleach. Complaisant people. They're also leading cause of poisoning resulting in stomach respiratory problems. And not surprisingly chemicals containing antifreeze paint, thinner chemicals pools. Also can act as Doug poison in the pet policing system that may produce include stomach upset depression, chemical, burns, renal failure and death. Oh, gosh..

Doug Pleasence Jim Ali Momo hurricane Irma Florida England painkillers Roger ibuprofen vomiting Lee serotonin syndrome Advil six months