23 Burst results for "Safran"

"safran" Discussed on Woman's Hour

Woman's Hour

05:45 min | Last month

"safran" Discussed on Woman's Hour

"Show. Curtis, please, can I just have some privacy? I'm only going in there to try some things on. Please. You know, she's right. She needs a privacy. Thank you. I'll go with her. Wow. Well, I'm joined in the studio today by actor at Safran hocking, who plays Lauren. And that little clip was chilling enough and, of course, if you watch the whole thing, it builds up and is quite terrifying. I wonder if you can tell us just a little bit about your character, Lauren, for those who haven't watched the show and what she's going through. Okay, hello..

Safran hocking Curtis Lauren
"safran" Discussed on Are You Just Watching?

Are You Just Watching?

05:33 min | 7 months ago

"safran" Discussed on Are You Just Watching?

"Else okay. I don't remember where he snuck him out of. But i'm pretty sure safran and that spoke cia. Agent hardy i think his name was. I think they were both working for seven for lucifer. San softened the bat. The big daddy right. Yeah but regardless of the fact anybody who had worked on such a project. Has you know the whole setup for that. Just that really bugged me that whole concept and it does make me worry about what goes on in government labs because you know whether wherever you stand on the current pandemic that we're suffering under. There is a lot of evidence showing that it originated least partially from a lab where they were working on a virus and whether it escaped or wasn't intentionally created intentionally set loose. Just pick your conspiracy but the point is that it probably did come from a lab and so it does make you wonder what people are working on these government labs and so it. This movie does kind of speak to hysteria of the situation. Since so many of us are working from home. I get to actually sit down and watch tv while. I'm eating lunch. One of the very few times that i actually get to sit and watch a program and i recently re watched the seven seasons of deep space nine over the last nine months or something like that and it occurred to me that one of the ways that star trek made aliens eighty million was to make them not abide by. You know natural law which is based in romans. two fourteen sixteen so gentiles. Who do not by nature have the law with the law demands. They are law to themselves. Even though they do not have the law they showed that the work of the law's written on their hearts or their consciences confirm this. They're competing thought. Either accused or excuse them on the day when god judges what people have kept secret according to my gospel. Jesus christ and it's the idea that there is a absolute moral law that exists in my point is is that when they wanna make a really bad villain..

Agent hardy safran cia San
"safran" Discussed on Conversations

Conversations

02:46 min | 8 months ago

"safran" Discussed on Conversations

"So the people who worked for philip morris. They have that story to tell their friends at dinner. Parties compared to the other cigarette giants if you work for british american tobacco or imperial brands which and the other two big ones you've got to say. You worked cigarette. Company philip morris. He gets to and and you get to believe that you're not working at cigarette company. You're working at a company. That's trying to end cigarettes. You're working in a science and dot up it so ingenious. I just i if we were all the smartest philip morris. I'm telling we'd all be living on the moon by now so you didn't get to go to the cube in switzerland because of it and you're stuck inside your you curious about that john but i was having the lunch thing. It was a very nice restaurant and it's only occurred to me at some point i'll wave. He's fine and then. I started getting paranoid. I'm going oh my god. He's he's fine like an east pocket and he's like recording this whole conversation like and it's going to be used against me at some future point and it was too late then accepted the junk. I was thinking. Oh my god he's got me on type accepting the junk it like. He's going to be able to use against me somehow. and then. Yeah when it happened. And the lockdown. And then i got the message from the dude and a very nice guy by the way. All these people are nice. He said to me all the obviously because of lockdown. Like it's it's off like you're not going to switzerland anymore. And i just thought oh my god. It's the worst of both worlds. Because i'm not gonna get to go on the junkers to the switzerland but also is perfect copy on type accepting these junket so a morally compromised at least by conventional understanding of that journalists compromise but didn't even get the benefit of the thin compromise. So yeah it was. The worst of world's john reveal the existence of an organization that i'd never heard of called p. m. impact what is. Pm i impact. What do they do. So it's a branch of philip morris or project to philip morris and they funding law enforcement projects around the world on a nominal level. It's i want to crack down on illegal cigarette smuggling and man. That's seems there's something to discuss that. Why is there an of law enforcement in america. That on the one hand is funded by tax payers but on the other hand. He's also getting some supplementary money. Frahm philip morris international then. I found this really interesting. Because it was part of my. I don't know annoyance or something that no one seems to be philip morris. Were just doing whatever they wanted. And no one was noticing and when it came to me. Finding out that philip morris were funding law enforcement around the world..

philip morris switzerland john Frahm philip morris america
"safran" Discussed on Conversations

Conversations

02:46 min | 8 months ago

"safran" Discussed on Conversations

"So the people who worked for philip morris. They have that story to tell their friends at dinner. Parties compared to the other cigarette giants. If you work for british-american tobacco or imperial brands. Which and the other two big ones you've to say. You worked cigarette company but philip morris he gets to and and you get to believe that you're not working at cigarette company working working at a company. That's trying to enter cigarettes. You're working in a science and text dot up it so ingenious. I just i if we were all the smartest philip morris. I'm telling we'd all be living on the moon by now so you didn't get to go to the cube in switzerland because of it and you're stuck inside your you curious about that john but having the lunch thing it was a very nice restaurant and it's only occurred to me at some point i'll wave. He's fine and then. I started getting paranoid. I'm going oh my god. He's he's fine like an east pocket and he's like recording this whole conversation like and it's going to be used against me at some future point and it was too late then accepted the junk. I was thinking. Oh my god he's got me on type accepting the junk it like. He's going to be able to use against me somehow. and then. Yeah when it happened. And the lockdown. And then i got the message from the dude and a very nice guy by the way. All these people are nice. He said to me all the obviously because of lockdown. Like it's it's off like you're not going to switzerland anymore. And i just thought oh my god. It's the worst of both worlds. Because i'm not gonna get to go on the junkers to the switzerland but also is perfect copy on type accepting these junket so a morally compromised at least by conventional understanding of that journalists compromise but didn't even get the benefit of the thin compromise. So yeah it was. The worst of world's john reveal the existence of an organization that i'd never heard of called p. m. impact what is. Pm i impact. What do they do. So it's a branch of philip morris or project to philip morris and they funding law enforcement projects around the world on a nominal level. It's i want to crack down on illegal cigarette smuggling and man. That's seems there's something to discuss that. Why is there an of law enforcement in america. That on the one hand is funded by tax payers but on the other hand. He's also getting some supplementary money. Frahm philip morris international then. I found this really interesting. Because it was part of my. I don't know annoyance or something that no one seems to be philip morris. Were just doing whatever they wanted. And no one was noticing and when it came to me. Finding out that philip morris were funding law enforcement around the world..

philip morris switzerland giants john Frahm philip morris america
"safran" Discussed on Conversations

Conversations

03:17 min | 8 months ago

"safran" Discussed on Conversations

"Have the same thing which are trying out which not forceful except the where. It's like teach the controversy and because my book it is. It's teaching the controversy. So i have no idea i might like what i'm doing because it's like with john's explaining these thing that no one knows about yet and even though it just sounds really bad. It's like better than nothing or something. So so i just think they thought well no one else is ringing them. So what happened at this lunch. Well i was pretty excited because there was a slight hint when i was at the booth in new zealand. The woman who worked for philip morris she did trump is kind of coded thing which would have been interpreted one way or the other where it was like. Hang on just like suggest. You might like pay for me to go on a junket to your headquarters in switzerland and i was dying hawk. That'd be kinda cool or whatever and then in the launch yes it was. it was Do you want to go to this. the cube is what they call it in switzerland. And that's interesting. You've got an offer to go to visit the cube. What in switzerland. What is the cube in switzerland. And that's when i do a science might also be the think tank area. I think i'd definitely it's like a science often bit. And i think maybe it's also you know what i think. They really clever things that was offered to you. What did you say. Oh i say yes. I could not believe my lot. I could not believe my luck that also during this book on how philip morris get their tentacles in everywhere and try to try to been things in their favor of like. Oh my god and now. They're doing it to me. I just couldn't believe my luck considered the study everything about them. These days suggests that they trying to look like apple yet rather than the tobacco company. Is that setting. You noticed yet. Definitely vice president was at a conference like a tech conference couple of years ago and she introduced herself as i'm senior vice president of science and tech startup philip morris and because this i cost has a computer chip in it she can say that and the employees feel really good because they're not working at a cigarette company they working at a and so sort of like an iphone that you suck on essentially the all the packaging is like an iphone. And you know it's about the i in front of it. Like i find but then also they have these dedicated stolz europe and they. They've opened a couple of america to and according to people who've gone and it's like you just walked pasta and you think it's the it's the apple store but get how ingenious philip morris by the fact that they get to say when other cigarette company anymore even though i by the way just to be clear they so eight hundred billion secrets. Yeah they sell the cigarettes wherever to the hilt wherever they can still sell them. This like is like for areas where that's no longer sustainable. Either for legal reasons or social reasons. But because. I'm put this this heat-seeking decide which isn't a cigarette. And because they say they're trying to get people onto that they say we're not a cigarette company. Where a company that gets people off cigarettes..

switzerland philip morris new zealand john apple europe america
"safran" Discussed on Conversations

Conversations

03:17 min | 8 months ago

"safran" Discussed on Conversations

"Have the same thing which are trying out which not forceful except the where. It's like teach the controversy and because my book it is. It's teaching the controversy. So i have no idea i might like what i'm doing because it's like with john's explaining these thing that no one knows about yet and even though it just sounds really bad. It's like better than nothing or something. So so i just think they thought well no one else is ringing them. So what happened at this lunch. Well i was pretty excited because there was a slight hint when i was at the booth in new zealand. The woman who worked for philip morris she did trump is kind of coded thing which would have been interpreted one way or the other where it was like. Hang on just like suggest. You might like pay for me to go on a junket to your headquarters in switzerland and i was dying hawk. That'd be kinda cool or whatever and then in the launch yes it was. it was Do you want to go to this. the cube is what they call it in switzerland. And that's interesting. You've got an offer to go to visit the cube. What in switzerland. What is the cube in switzerland. And that's when i do a science might also be the think tank area. I think i'd definitely it's like a science often bit. And i think maybe it's also you know what i think. They really clever things that was offered to you. What did you say. Oh i say yes. I could not believe my lot. I could not believe my luck that also during this book on how philip morris get their tentacles in everywhere and try to try to been things in their favor of like. Oh my god and now. They're doing it to me. I just couldn't believe my luck considered the study everything about them. These days suggests that they trying to look like apple yet rather than the tobacco company. Is that setting. You noticed yet. Definitely vice president was at a conference like a tech conference a couple of years ago and she introduced herself as i'm senior vice president of science and tech startup philip morris and because this i cost has a computer chip in it she can say that and the employees feel really good because they're not working at a cigarette company they working at a and textile sort of like an iphone that you suck on essentially the all the packaging is like an iphone. And you know it's about the i in front of it. Like i find but then also they have these dedicated stolz europe and they. They've opened a couple of america to and according to people who've gone and it's like you just walked pasta and you think it's the it's the apple store but get how ingenious philip morris by the fact that they get to say when other cigarette company anymore even though i by the way just to be clear they so eight hundred billion cigarettes they sell the cigarettes wherever to the hilt wherever they can still sell them. This like causes like for areas where. That's no longer sustainable. Either for legal reasons or social reasons. But because. I'm put this heat-seeking decide which isn't a cigarette. And because they say they're trying to get people onto that they say we're not a cigarette company. Where a company that gets people off cigarettes..

switzerland philip morris new zealand john apple europe america
"safran" Discussed on Conversations

Conversations

05:45 min | 8 months ago

"safran" Discussed on Conversations

"John into with vaping expo zealand with a group of people in the industry. That's where you met. Some people from philip morris. What happened when you approached them. Air will have to get on a knees. Eland because philip morris. When i first was interested in the story i contacted them and said like to write about your smokefree future. And they're like. Oh john we'd love you to come on in. That would be great. You can talk to wherever you want. We can show you whatever you wanted. Or whatever so i was like oh my god this is so so i run off to my publisher and our pitch them the book go on my god. They're gonna give me access behind the scenes and everything and they said. Yeah okay call on you know. They signed me on to do it. Then i i noticed philip morris got back to me wild so i contacted me again i go. Can i come in. And they said yea. Actually we've had another thing about it. And no and so i was like. Oh my god you jerks because this went through my publisher and got a book deal based on this and now you've left my flapping in the wind showed and then i noticed that we're going to have a stall that these vape expo in new zealand in auckland new zealand side just got on applying went there and then yeah like what can they do like so i just wanted up to the booth and awesome questions and much to the chagrin of people in the viper industry. They'd got the prime real estate at the expo. The lead like the biggest booth and it was also like right. Need the entrance. So you could not walk into this vibe expo. Without walking through the philip morris heat streak booth and people in developing a kind of a bit annoyed that got cigarette companies getting involved because it makes it all murkier but having said that. The people who worked for philip morris especially like the younger ones..

philip morris Eland zealand John new zealand john auckland
"safran" Discussed on Conversations

Conversations

04:19 min | 8 months ago

"safran" Discussed on Conversations

"There is no shortage of maori organizations. And mary flew like what is. That's a very specific thing. This one philip morris. That group does a friend in the uk. Since you pick from the london underground a billboard quitting smoking headline never looked back at that in its involvement with vice. The sort of edgy meteoroid guys. -ation game will in today's world e can't look at an anti-smoking campaign an issue. It's all face value. Because philip morris have built what i call them the book. These kind of shadow land created anti smoking campaigns at first blush. Seem like what. You'd get from quick victoria or the world health or when is asian or the hop foundational. Things like that. But they're actually anti-smoking hedge reverse engineered by philip morris to achieve the aims that they want to achieve and what other games now is. The time is just a shift. People essentially from cigarettes. Yes to the new high costs and he'd stick. Yes but at the moment. If you talk to a mainstream anti-smoking group that say yeah. We're trying to stop the tobacco trade while philip morris of being very clever. They're saying none. We don't stop the tobacco. Try to go out the smoking business. And then they claim that they knew device doesn't generate smoke so it's not the problem so they've started creating these anti anti-smoking campaigns that just little charlie mainstream in normal but the very tricky because in where the world holdover is i would say. Stop inhaling tobacco. Philip morris deci. Oh no no stop inhaling smoke and then they claim this new thing is in smoke. Eso in the london underground. That was the vice anti-smoking campaign. Then you go to the website. And it's like yeah. You should stop cigarettes altogether. But if he can't do that one sort of something been in between you know maybe try out e cigarettes which and obviously like quick. Victorio the woodhall. When i action wouldn't be saying that. Why don't they just in the vape business because stories of us congressional inquiries into big tobacco where they found correspondence between officials in the big tobacco companies. They admit the wearing the nicotine delivery business. That's what they call themselves..

philip morris london Philip morris deci mary victoria uk Victorio charlie
"safran" Discussed on Conversations

Conversations

05:12 min | 8 months ago

"safran" Discussed on Conversations

"That foundation they fully fund and indigenous health organisation in new zealand. And it's run by these. Mary woman and she presents the argument for philip morris in very woke wisely not even like conventional wise for instance. It becomes who a white people to tell indigenous. People what to do they should be indigenous self-determination therefore when you have like new zealand anti-smoking campaigns trying to tell marry people to stop smoking. Because they've they're highly overrepresented compared to other new zealanders in smoking that's like white colonizers trying to tell indigenous people. What to do. That's like white outside is coming in and being is and just just to be perfectly clear. There is no shortage of maori organizations. And mary flew like what is. That's a very specific thing. This one philip morris. That group does a friend in the uk. Since you pick from the london underground got a billboard. Quitting smoking headline never looked back at that. In its involvement with vice. The sort of edgy meteoroid guys. -ation game will in today's world e can't look at an anti-smoking campaign an issue. It's all face value. Because philip morris have built what i call them the book. These kind of shadow land created anti-smoking campaigns at first blush. Seem like what. You'd get from. Quick victoria or the world health or when is asian or the hop foundational. Things like that but they're actually anti-smoking hedge reverse engineered by philip morris to achieve the aims that they want to achieve and what other games now is the time is just a shift. People essentially from cigarettes. Yes to the new high costs and he'd stick. Yes but at the moment if you talk to a mainstream anti-smoking group i'll say yeah. We're trying to stop the tobacco trade while philip morris of being very clever they saying none. We don't stop the tobacco. Try to go out the smoking business. And then they claim that they knew device doesn't generate smoke so it's not the problem so they've started creating these anti-smoking campaigns that just little charlie mainstream in normal but the very tricky because in where the world holdover is i would say. Stop inhaling tobacco..

philip morris new zealand Mary mary london uk victoria charlie
"safran" Discussed on Conversations

Conversations

04:03 min | 8 months ago

"safran" Discussed on Conversations

"This is an abc podcast. I'm not a smoker. And i hardly ever encountered cigarette smoke in my life anymore. Sometimes i see people buying fags furtively at the supermarket and the pistons smuggling them in the street outside but other than that. I haven't been paying attention to be tobacco. And so. I missed it in two thousand eighteen. When philip morris international cigarette giant launched a pr campaign their ceo made this video for their website. Which looks like one of those apple. Corporate videos put out for new high tech product in this video. He announced the corporations new mission to unstuck the world. You're going into the territory which was completely unchartered. Nobody ever tried to smoke the word. The science exists today and there is no time to support to solve the problem of smoking. This is phillip. Morris international which makes.

philip morris international ci abc pistons apple Morris international phillip
GE and Safran Are Developing Cleaner Energy Aircraft Engines

The KFBK Morning News

00:17 sec | 1 year ago

GE and Safran Are Developing Cleaner Energy Aircraft Engines

"And Safran working on a clean energy aircraft engine, and they feel like they can get those tests started in a few years using hybrid hydrogen technology, and G says they can cut emissions. About 20% off of today's use, Novak says they have

Safran Novak
New York Gov. Cuomo Lashes Out at Critics As Outcry Over Nursing Homes Grows

What Next | Daily News and Analysis

05:14 min | 1 year ago

New York Gov. Cuomo Lashes Out at Critics As Outcry Over Nursing Homes Grows

"It's criticism of new york state coronavirus response. That's irritated governor cuomo to the point of lashing out specifically criticism of how the governor's office has been counting the deaths of cove patients in nursing homes. So i asked jimmy veal kind to take me back in. Explain how this data error could lead the governor to reveal a less savory side of his personality a side of himself. he's managed to keep under wraps at least for the last few months it turns out this data error. It's tangled up in some policy decisions. The cuomo administration made about nursing homes way back at the beginning of the pandemic. You have to start in the first week of march where there were lots of unknowns. Far more was was not known them was known and governor cuomo had had just sort of his did over a slow glide shutdown of the state finally came to pass on on march twenty. It took him a while to make the decision. There is a week of sort of incremental closures. Different people debated whether or not he should have acted faster. But that's sort of was was decision point number one decision point number two was concerned about hospital capacity in certain that the fires it already spread pretty widely. More people are getting affected in governor. Cuomo talks time and time again about images that he saw from italy where hospitals were overrun where patients were outside on gurneys or stuffed into hallways and people were essentially being turned away and he said so often that that was his biggest fear so in that environment hospital. Executive talked to the governor's team in said we've traveled. We have patients who no longer need to be. Hospital is but they're sitting in our beds because we have no place the discharge them the normally would get discharged homes either. I kind of probably or for a long-term residents but the nursing homes were saying we're really scared. We don't want these covy positive patients and so you have this tension between nursing homes and hospitals and what new york state did was it. It basically listened to the concerns of hospitals so march twenty fifth the state health department issued a directive which said that a nursing home could not refuse to admit a patient which it would otherwise be able to care for solely on the basis of being positive for covid nineteen a nursing. Home operator said this was effectively in order to take these patients in some of immediately objected. They immediately said we're concerned. This is going to exacerbate the spread of covid nineteen facilities but the order stood. Was there evidence that it did exacerbate the spread in their facilities. Well this is where it gets tricky. We know that thousands of patients were transferred from hospital into nursing homes around the state retreat march twenty fifth and may ten when this health department directive was re modified rescinded revert. You can you can take your so. The question is did. The corona virus come to nursing homes the result of this in july. The state health department put out a report which looked at the data and it looked at the dates of death. The dates of first positive cases in nursing homes around the state. It's inclusion was that in most nursing homes. The first introduction of corona virus happens before any of these patients were transferred before the directive was issued on march twenty fifth. It was staffers bringing it in. They lead that. It was safran because the correlation because the infection rates in nursing homes correlated with the surrounding community right. Obviously a nursing. Home doesn't exist. In a bubble people work there. You know somewhere else to live. And the health department said this was actually the factor even though nursing home operators said from the beginning. Hey this order. It's not helping. It's only hurting and to this day. There are operators to say that they believe it contributed to the spread. If not in some instances was the primary ause of the spread. It's unclear even now whether this policy forcing nursing homes to take in covid positive patients affected newark's total death toll that's because of a pretty grim calculus. It's possible that additional deaths in nursing homes were actually offset because freeing hospital beds allowed more coronavirus patients to be treated what we do know now. At least is that cova deaths in nursing homes. Were not being tallied correctly. That's because of a patient became so sick. They were transferred back to a hospital. That death was counted as a hospital. Death making it nearly impossible to understand. Just how much. The virus was ravaging long term care facilities.

Governor Cuomo Jimmy Veal Cuomo Administration State Health Department New York Cuomo Italy Safran Health Department Newark
A Look At The Building Blocks Of Stem Cells

Sounds of Science

04:43 min | 1 year ago

A Look At The Building Blocks Of Stem Cells

"From mouse models in one, thousand, nine, hundred, one to cloning Dolly the sheep to a couple of Nobel prizes. Stem cells have had an exciting half-century. But rearranging the building blocks of life is not easy and more importantly for patients not fast. However, newcomers on the market are ready to change the stem cell programming for the quicker. Joining me today are Mariangela, I o Vino Group leader integrated biology at Charles River Saffron Walden site and Mark Qatar. The founder of the cellular reprogramming startup bit bio. The are here to discuss the innovative technology created by mark and his associates and how it can be exploited by end users like Mariangela welcome Mariangela. Thank you welcome to Beautiful Safran. World. Nice, weather? Yeah. Not Bad. So can we start at the beginning? What are stem cells briefly? So stemmed has really the origin of any complex organism. Their form pretty much after an expert. And role is ready to reproduce all the cells. In the body of a human or or an animal. And the cool thing though is that Yamanaka in two thousand seven showed that one doesn't have to fertilized egg to produce stem cells. You can also produce them synthetically using salary programming, and that really has opened up the use of stem cells for drug discovery and can locations. Cool. All right. What practical uses do stem cells have for drug developers? I think that the DAW to using human cells in drug development this is really important because there's a huge translation gap at the moment between. The animal models and cell lines that are traditionally used right and. The high failure rates that you see in clinical trials. Yeah. Totally the boiled on to two things I drugs because they're toxic to human or because they don't work the human setting and so at the center of all this differences between the species used for drug development at us as the end uses. So you're saying is that the stem cells can be made from human cells and that way they're tested on human cells instead of a different species. That's exactly right. Okay. That makes sense. So how were stem cells traditionally used to create sells like brain cells? So the traditional paradigm was to try and repeat what happens during development when embryo grows in Utah and so researchers for the last twenty years or so tried to. Create protocols that expose cells to extra Selah cues, molecules that exist in the growing embryo and instruct them direct them towards particular cell fates. One of the problems that you have if you repeat this paradigm, of course, you're bought into the timelines of of Embryo Genesis, which basically means it often takes sixteen hundred days plus to generate human sale. and. The other problem that you have when you adopt this, this method is that you have to overcome the diversity that nature requires to create cells. So the worst thing that can happen during development is if a lineage, an organ or a cell type isn't produced raced. And Soak Nature seems to. Prevent. This using. CASSIE principles. So these cells make cell fate choices all along the way. If you think about a protocol that takes sixty one, hundred days with multiple steps were cells make these choices than you end up with inconsistencies. So inconsistency and longtime nine's really the biggest bottleneck introduced new Simpson about. So it's basically I, mean if we're trying to imitate nature nature is trying to make all of the organs we may be only want brain. So using nature's methods is a little bit tricky. So I would say if you wanted to produce a particular cell type, it's very tricky. In terms of producing elements of an organ. It's probably slightly less tricky although you still have the inconsistency question right and then this new paradigm called cell reprogramming. Which is essentially. An expansion or reverse engineering of Yamanaka reprogramming. Provides an alternative route so you can now very efficiently in very quickly. Produce. Human cells using. Synthetic biology paradigm

Mark Qatar Charles River Saffron Walden Mariangela Founder Beautiful Safran Yamanaka Vino Group Utah Selah Simpson
Building the Building Blocks of Life

Sounds of Science

04:48 min | 1 year ago

Building the Building Blocks of Life

"I'm Mary Parker and welcome to this episode of Eureka Sounds of science from mouse models in one, thousand, nine, hundred, one to cloning Dolly the sheep to a couple of Nobel prizes. Stem cells have had an exciting half-century. But rearranging the building blocks of life is not easy and more importantly for patients not fast. However, newcomers on the market are ready to change the stem cell programming for the quicker. Joining me today are Mariangela, I o Vino Group leader integrated biology at Charles River Saffron Walden site and Mark Qatar. The founder of the cellular reprogramming startup bit bio. The are here to discuss the innovative technology created by mark and his associates and how it can be exploited by end users like Mariangela welcome Mariangela. Thank you welcome to Beautiful Safran. World. Nice, weather? Yeah. Not Bad. So can we start at the beginning? What are stem cells briefly? So stemmed has really the origin of any complex organism. Their form pretty much after an expert. And role is ready to reproduce all the cells. In the body of a human or or an animal. And the cool thing though is that Yamanaka in two thousand seven showed that one doesn't have to fertilized egg to produce stem cells. You can also produce them synthetically using salary programming, and that really has opened up the use of stem cells for drug discovery and can locations. Cool. All right. What practical uses do stem cells have for drug developers? I think that the DAW to using human cells in drug development this is really important because there's a huge translation gap at the moment between. The animal models and cell lines that are traditionally used right and. The high failure rates that you see in clinical trials. Yeah. Totally the boiled on to two things I drugs because they're toxic to human or because they don't work the human setting and so at the center of all this differences between the species used for drug development at us as the end uses. So you're saying is that the stem cells can be made from human cells and that way they're tested on human cells instead of a different species. That's exactly right. Okay. That makes sense. So how were stem cells traditionally used to create sells like brain cells? So the traditional paradigm was to try and repeat what happens during development when embryo grows in Utah and so researchers for the last twenty years or so tried to. Create protocols that expose cells to extra Selah cues, molecules that exist in the growing embryo and instruct them direct them towards particular cell fates. One of the problems that you have if you repeat this paradigm, of course, you're bought into the timelines of of Embryo Genesis, which basically means it often takes sixteen hundred days plus to generate human sale. and. The other problem that you have when you adopt this, this method is that you have to overcome the diversity that nature requires to create cells. So the worst thing that can happen during development is if a lineage, an organ or a cell type isn't produced raced. And Soak Nature seems to. Prevent. This using. CASSIE principles. So these cells make cell fate choices all along the way. If you think about a protocol that takes sixty one, hundred days with multiple steps were cells make these choices than you end up with inconsistencies. So inconsistency and longtime nine's really the biggest bottleneck introduced new Simpson about. So it's basically I, mean if we're trying to imitate nature nature is trying to make all of the organs we may be only want brain. So using nature's methods is a little bit tricky. So I would say if you wanted to produce a particular cell type, it's very tricky. In terms of producing elements of an organ. It's probably slightly less tricky although you still have the inconsistency question right and then this new paradigm called cell reprogramming. Which is essentially. An expansion or reverse engineering of Yamanaka reprogramming. Provides an alternative route so you can now very efficiently in very quickly. Produce. Human cells using. Synthetic biology paradigm

Mark Qatar Mary Parker Charles River Saffron Walden Founder Mariangela Beautiful Safran Yamanaka Vino Group Utah Selah Simpson
Culture Cults Week

Feedback with EarBuds

03:22 min | 1 year ago

Culture Cults Week

"This week's theme comes to us from Sean Abraham Preston and is called culture colts. Here's why Sean chose this theme. He writes. Hi. I'm Sean Abraham Preston and the theme I chose is culture. Cults Chose the theme because I'm fascinated with Howard devotion to new cultural ideals can cross over into spirituality in the worship of other people oftentimes with dark consequences. Were especially vulnerable to this when we're searching for meaning in Tumultuous Times of change. Like twenty twenty, for example. Here, are the episodes chosen by Sean for this week's theme along with short descriptions of each episode. The first one comes to us from the podcast strangers and is called the sun the Goddess Leopoldo. It's forty six minutes long. Here's the description. Born in a coven of lesbian witches in a Haight Ashbury commune after the fall of Saigon Young Joshua Safran soon hit the open road with his single mother and things only got stranger from there. A. Word of warning this story contained some disturbing moments. The next episode comes to us from. You must remember this is called Charles Manson's Hollywood part three, the beach boys, Dennis Wilson and Charles Manson Songwriter. It's forty seven minutes long. Here's the description. In this episode, we'll talk about Charlie Manson's arrival in Los Angeles. We'll discuss Dennis Wilson's life and the role he played in enabling Manson's rock and roll delusions, and we'll explain how the beach boys came to record a song written by Charles Manson. The next episode comes to us from friends of the friend called the beautiful cripple part one. It's forty nine minutes long. Marilyn Manson fan and a Silicon Valley's tech, Colt Cross paths in an adventure that ends in supernatural sex and murder. The next episode comes to us from Decoder Ring and is called the basement affair. It's forty three minutes long. Here's the description. What are the real reasons people go on reality? TV. This episode follows the story of an Hirsch and Kathy Nardone two women cast on VH1's Frank. The entertainer in a basement affair a show about an adult man looking for love while living in his parent's basement. How did one performance artists and one accidental performance artists make it onto the show and how did they behave once they made it their. Their story highlights the ways that reality television distorts narratives, obscures intentions, and stereotypes women, yet it's still irresistible to audiences and performers like. The last episode of the week comes to us from invisible era and is called the end of empathy. It's fifty two minutes long. Here's the description. In. Is a show that runs on empathy we believe in it, but are we right? In this episode, we'll let you decide. We tell you the same story twice in order to examine the questions who deserves our empathy and is there a wrong way to empathize? Those are the episodes chosen by Sean for this week's theme Culture Colts.

Sean Abraham Preston Charles Manson Marilyn Manson Dennis Wilson Twenty Twenty Goddess Leopoldo Tumultuous Times Haight Ashbury Joshua Safran Howard Colt Cross Los Angeles Murder Hollywood Hirsch Kathy Nardone VH1 Frank
"safran" Discussed on KTOK

KTOK

01:43 min | 2 years ago

"safran" Discussed on KTOK

"Say one in the same we don't want to frame it is is they they are they're different yeah there definitely they're definitely separate they're definitely Safran Luna said the devil I mean that's a that's a small word processing giant force good good good I I was referred to as the lord of darkness the father of darkness indeed it is a a docking on of course no one introduction chaotic but it doesn't necessarily mean you will notice I mean malevolent to humans but that it is the force of change that that that you didn't in in Jackson the the the the chaotic force that is then counterbalanced by the life force the creek the union thing good luck that really create everything and keep everything sustained so that world of darkness is a necessary part of the whole connection issues we look back to Persian miniatures or Astorino them where it was understood that but or a monster of a gun of lighting creation was the exact equal offices of I remind you or the that the lord darkness I think they're not you we in our hand in favor Hanneke religion it's gotten to the mess has got to the point where where the jealousy that fifteen percent figure that's that's earth bound to hell bound or or whatever yeah that's a pretty name understanding of it the more ancient understanding was that the these things are come beyond good and evil they are they are necessary forces of nature and as the demons are no more evil than war is evil when I leave the city for lamb have.

Safran Luna Jackson lamb Hanneke
"safran" Discussed on KOA 850 AM

KOA 850 AM

02:21 min | 2 years ago

"safran" Discussed on KOA 850 AM

"I would require that the power of a very ancient very powerful spirit and and those are the ones I like to work with the mouse what are in your opinion demons where do they come from most most demons that will finally win once or in books giving ology you can trace them almost every single one of them you can trace back to ancients merry or to the canine and either of these are all almost always changing gods and goddesses and as well as one culture subsumes another yeah the truth seems to get instantaneously change by the more powerful culture or the language and their religion if you can change the gods of people worship attendance and to demand have you changed the words of those people use in their daily life you've got in mind and and sense that there is a a powerful powerful weapon used for as far back as we can see to civilization so most of these games actually are changing god most of them being much more ancient than than the gods are worshiped him later hands are the evil I mean the name demons seems evil yeah I'm not pulling the name dime on can you believe just basically about spiritual power genius and has developed a a negative connotation through time are the evil evil the transhuman concept they are powerful and they work in a way that is so mysterious to us as it is seems often to be chaos I mean do they work for the devils or do they work for god well this little little little more binary then I think we can really give us with this that god and the devil are really on the same don't say one in the same hole there but no one in the same issue they they are they're different yeah there definitely they're definitely separate they're definitely Safran Luna said the devil I mean that's a that's a small work for fishing giant force good good good I I would just refer to this as the lord of darkness the father of darkness and it is a a docking on of course now transaction chaotic.

devils Safran Luna
"safran" Discussed on 600 WREC

600 WREC

01:43 min | 2 years ago

"safran" Discussed on 600 WREC

"Say one in the same we don't want to frame it is is they they are they're different yeah there definitely they're definitely separate they're definitely Safran Luna said the devil I mean that's a that's a small word processing giant force the the the right I would just refer to this as the lord of darkness the father of darkness indeed it is a a doctor chaotic force no more introduction chaotic but it doesn't necessarily mean you will notice I mean malevolent to humans but that it is the force of change that that that even in in Jack's the the the the chaotic force that is then counterbalanced by the life force the Caribbean Yang that really create everything and keep everything for this thing so that world of darkness is a necessary part of the whole meeting actually fuse we look back to Persian miniatures or Astorino them where everyone just did that that was or a monster of a gun of lighting creation was the exact vehicle offices of I remind you or the that the lord darkness I think they're not you we in our hand in Iran that religion has gotten to with the message got to the point where where the jealousy assistant push the United States down to hell bound or or whatever yeah that's a pretty name understanding of it the more ancient understanding was that the these things are beyond good and evil they are they are necessary forces of nature and and the demons are no more evil than war is evil entity you for lamb have.

Safran Luna Iran United States Jack
"safran" Discussed on Bloomberg Radio New York

Bloomberg Radio New York

01:32 min | 2 years ago

"safran" Discussed on Bloomberg Radio New York

"Day thank you Peter Safran global macro strategies at all BC will be joining not better myself coming up next trade stimulus Powell and much more listening to be vague daybreak here wow hi I'm Jay Farner CEO of quicken loans America's largest mortgage lender let's talk credit card debt for a minute if you feel you're carrying too much of it you're not alone the average household in the U. S. carries over eight thousand dollars in credit card debt ready for some good news with a cash out refinance from quicken loans you can quickly and easily put some of the equity in your home to good use by paying off a lot of that high interest credit card debt a great way to take cash out is with our thirty year fixed rate mortgage the rate today in our thirty year fixed rate mortgage is four point one two five percent APR four point two two percent call us today at eight hundred quicken to learn how taking cash out with a thirty year fixed mortgage might be the right solution for you and for a record nine years in a row JD power his right quicken loans highest in the nation in customer satisfaction for primary mortgage origination call us today at eight hundred quicken or go to rocket mortgage dot com for JD power word permission as a Jedi part account rates of exchange between eight eight percent fee to receive the discount rate cover costs information in conditions causing water license in all fifty states and one hundred thirty thirty hi it's Jamie progresses number one number two employee leave a message at that hi Jamie it's you Jamie don't hang up you need to hear this you gotta quit wearing that aviator jacket nobody's buying it sorry you have to hear.

BC CEO America Jamie Peter Safran Powell Jay Farner quicken thirty year eight thousand dollars one two five percent eight eight percent two two percent nine years
"safran" Discussed on 77WABC Radio

77WABC Radio

01:39 min | 3 years ago

"safran" Discussed on 77WABC Radio

"Eight eight eight nine eight eight Josh that's eight eight eight nine eight eight Josh now, let's get back in the huddle with the financial quarterback. I'm just met about sat from. Safran? Just. She's just mad about me. Manda. Me. Okay. We have next. Tom. Go ahead. You're Josh Chilin ski.

Josh Chilin Safran Tom
"safran" Discussed on KNST AM 790

KNST AM 790

02:32 min | 3 years ago

"safran" Discussed on KNST AM 790

"Speaking about bees biscuits. I don't want to continue. Great name for a ban. Biscuits. What I can tell you this show without doing some very special shoutouts. Yeah. And I really encourage I know Texas would probably get some calls northern border everyone. I'm sure there's a lot of businesses throughout the United States that are doing this. But I really wanna give a shout out to the ones I'm aware of because I'm in Tucson, right? Yeah. So sufferin Indian bistro. Am I saying that Safran gosh darn close? It's closer butchering. I've been there the food is really good. And they've got two locations now Safran Indian bistro. One is seventy six or seven north oracle. Right. This is what is under site. They would like to continue to offer a free lunch buffet to all federal employees free lunch buffet to offer employees affected by the government shutdown. We know there's a great need to help. And there are many people out there still thank you to all who have posted their comments. I mean, they go on and on they said, please share. So I mean, that's what they're doing. That's video guidance. Makes me want to cry us. Honestly, does I think I might go out there and just sit out there and give away green shirts. Let's kinda cool. I might do that. I said there was a guy sitting there and on video and it looked like he was wearing a green light shirt. So another one we have is the parish. And it says for the entirety of the shutdown. The parish will be serving free goodies Gumbel and hush puppies to federal boys. Gomo sounds good is good to Louisiana food. That's really good. Yeah. The Gumbo wonder if it's real combo. It's gotta be right anyway, six four or five three hundred so go out there. The reason I mentioned these places is because not gonna get a free meal, but people that are supporting and you go through these businesses because here you have been this is that really care. They're not in Hawaii. Like Nancy wearing bikinis. Often Puerto Rico, they're here with businesses and they're offering this to help federal employees. It's I think it's awesome. Hush puppies. Great. That will what's his name like them? Not just as a son. Oh, yeah. He liked them. Puppies. Daddy..

Safran Indian Indian bistro Safran Tucson Puerto Rico Gumbel government United States Texas Nancy Louisiana Hawaii
"safran" Discussed on Hypnosis and NLP with Donald Currie

Hypnosis and NLP with Donald Currie

05:27 min | 3 years ago

"safran" Discussed on Hypnosis and NLP with Donald Currie

"Relaxed. Mentally examining your body for any areas of tension. And just allow those areas of tension. To disown. And dissipate. The deeper that you allow yourself. To move into relaxation. The better that you feel. And the better the chill field deeper. The choko. Bring your awareness cheer islets for moment. And just notice the quality of relaxation in your eyelids. Is it possible for you to relax all of the muscles in and around your eyes? So that they become show heavy. Show comfortable. And so tired that it simply feels as though it would be impossible for you to open them. And I wonder if it's possible. To allow that quality of relaxation. That same feeling of relaxation, and your I let. Just allowing that feeling. To flow through every muscle. If refi Bor. Every cell of your being. From the top of your hat. All the way down. To the tips of your toes. Every part of you. Relaxing completely now. And if any part of you is not completely and totally relaxed. Just do whatever you need to do. If you need to move your body in any way. You can do. So now. You can make any necessary mental or physical adjustments. Now that will help you to relax if in more. That's right. And to help you move further into relaxation. I'm going to count from one to twenty. With every number ally yourself to become more and more relaxed. More and more at ease. Higher. The number. The more deeply relaxed. You will become. More deeply, relax. Higher. The number. Mom. Two. Three, relaxing, more and more. Four. Five letting go. Sakes. Safran? Deeper and deeper lax. Nine. Ten. Aletta? Twelve. The teen. For ten. Fifteen. Sixteen. Seventeen. Eighteen. Nineteen.

Safran
Baltimore Ravens sign former first-round pick Robert Griffin III

News and Perspective with Herb Weisbaum

02:27 min | 4 years ago

Baltimore Ravens sign former first-round pick Robert Griffin III

"They need all of that extra room to stay safe there will also be rolling slow downs and lane closures most of those between eleven pm and four am so they won't impact the commutes but be aware a lot of this work is certainly weather dependent that's lee stole reporting some researchers at the university of washington may challenge a favorite genre of music komo's brian calvert with more on the unique mammals singing the tunes for ten years ocean agra for kate stafford and her team have been listening to whale songs but not just any whale that's the unique song of the bow head whale safran under team has quite a collection of bo head recordings when the times asked her to describe the unique style she said if humpbacks are like classical musicians bowheads are the jazz singers she goes on to describe the bullhead singing they shriek they moan they cry and they rattle and they whistle and they stafford says these creatures of the arctic breakout in constant song between november and april each year but the lyrics are different from year to year that's a lot of creativity considering a bow head can live up to two hundred years brian calvert komo news one forty one at komo news time for an update on sports with tom glasgow king felix gets his second start of the season as the gophers sweep of their two game series against the giants in san francisco johnny cueto will start for the home team and a game set to get underway at four fifteen one final in today in major league baseball from the national league braves knocking off washington to one robert griffin the third poised to resume his nfl career about thirty five miles away from where it started the former washington redskins quarterback has reached a one year deal with the baltimore ravens their head coaches john harbaugh i believe a players person and you know it makes us all the press conferences griffin was last in the league in twenty sixteen injury plagued season with the cleveland browns he started five games coming up with one victory southern cows.

Komo Cleveland Browns John Harbaugh Baltimore Ravens Washington Redskins NFL San Francisco Gophers Tom Glasgow Brian Calvert University Of Washington LEE Robert Griffin Washington Braves Johnny Cueto Felix Kate Stafford Two Hundred Years Ten Years