19 Burst results for "Rhonda Patrick"

"rhonda patrick" Discussed on Babes and Babies

Babes and Babies

06:57 min | 7 months ago

"rhonda patrick" Discussed on Babes and Babies

"That thought before too I remember thinking I was just so tired and I'm like man it'd be so much easier. If veto could just give her bottles I don't have to like. Pump or worry about it. So he could get up in the night there too and And it was just reassuring hearing the science behind breast milk and I learned so much because. It's so amazing what our bodies do and how we are breast milk changes and just all the. I guess I don't know the right word I guess ingredients just all the factors in it that are beneficial to you and the baby. So she's going to educate us today on that and I can't wait for you guys see her interviews I'm going to get right to it. All right, everyone I've Doctor Rhonda Patrick here who I'm super excited about I've been following her for quite a while and she is a doctor and biomedical science and she's an expert on nutritional health and I've loved following her because she comes out with so much information. She's that person at dives in deep into fact since statistics and the science and just gives it to you real and so I'm so excited that she's here to talk to us about the science of breast milk. So thank you so much for coming on. Elizabeth for having me and as I mentioned earlier when we were chatting. A. Huge congratulations to you You just had your daughter. Was It ben like three weeks not even yet right not even been. Two and a half I feel like it definitely starts to go into a blur. So she was born on. September first. Yeah I mean the first couple of weeks or kind of like you're in a cave to because you'd like don't go outside. But like just a little background about myself, you know I am a scientist by training. Not a medical doctor. So I have a PhD in Biomedical Sciences You mentioned I've done research on aging using little nematode worms looking sort of the genetics of aging done research on cancer. And Cancer Metabolism. at St Jude, Children's Research Hospital which is where I did all my graduate work research and then I went on to do postdoctoral research in nutrition and metabolism where I did more work on the clinical side. Looking at how micronutrient deficiencies can affect metabolism can affect. You know basically the way you age and. So you know I. At that point sort of took A. Different Path from doing you know bench work and. Research and science at the bench and I decided to to get more into the communication aspect of it where I communicate science behind a variety of what I think are low hanging fruits, things that people can. Apply in their lives now to have a positive impact on their health mental health physical health have an impact on the way they age disease prevention and things like that. So that's that's my passion But three years ago I became a mother I gave birth to my son almost exactly three years ago so. So, of course my. My interest. Are are still an aging, but also now sort of shifted to child development. So that sort of a more more focus of your podcast is. yeah. Well, when you talk about aging I feel like that's obviously a whole nother episode but I know any mom's listening their ears perk up there like aging. Do you have secrets for like not aging you know 'cause there's so much information out there but I mean you dive into the micronutrient deficiencies which I mean again, that's such a wide topic, but you see so much just even in environmental change in our soil and so many different things that are affecting every single aspect of our lives down to now even breast milk. So the health of the MOM. I listened to your video which was fascinating because. You know it's amazing how resilient our bodies are our babies are. And how we're still. They're able to get the things that they need, but not all food is created equal. Yeah. You know. So the first the first food that a baby gets is ideally breast milk and I went before we talk. About a lot of the benefits of breast milk just sort of briefly mentioned that you know none of this is to diminish the hard work of mothers that have formula or partially form the Fed infants I mean there's You know there's there's many reasons challenges to some women who unfortunately can't breastfeed and so it's just important to realize I. as you mentioned earlier, you know the humans really can adapt and not only that but thrive in. Broad range of conditions. So that's not to say that you know babies that were that were Formula Fed Joan Excel right. So this is something I think. I'd like to mention sort of upfront. Absolutely. But Breast milk, it's it's it's very different from from you know cows, Malcolm, there's lots of really just amazing components to it. You WanNa probably the the most interesting aspects is the. Their breast milk has something in it. That is it's a complex indigestible sugar. It's called the human milk oligosaccharides or HMO's for short. Like two hundred different HMO's in breast milk and. They are. So it's basically a third most abundant factor after knock toast and fat. But they can't be digested by the baby at all and yet it's like the third most abundant factor and milk isn't that interesting right? Why is it there? How it has a very special purpose of setting up and feeding the infant gut microbiome, which you and I were chatting about a minute ago. So the bacteria in the gut. Do. Quote unquote eat these HMO's they ferment them and The. HMO's. Help to. Basically ward off any potential pathogenic type of bacteria that can grow and they really just. Help. The what's called commenced bacteria or the healthy bacteria in your gut flourish. So that is super cool you know that. You've got this these these complex indigestible.

HMO Biomedical Sciences Doctor Rhonda Patrick Fed Research Hospital Elizabeth postdoctoral research scientist St Jude Joan Excel Malcolm
"rhonda patrick" Discussed on Babes and Babies

Babes and Babies

02:06 min | 7 months ago

"rhonda patrick" Discussed on Babes and Babies

"I am a proud military spouse and have one nineteen month old son and pregnant with my second I work part time from home in real estate. I. Am Jamie and I, am a rock Mama. Welcome back to the Miraculous Mama's podcast I'm your host Elizabeth Joy, and we believe in empowering women through storytelling an education and today is going to be educational because I have doctor. Rhonda Patrick on who is a complete be A. She's awesome. I've been falling her for a long time She's so smart and we dive into the Science of Breast Milk and I'm super excited share this episode with you because it came out I got an interview her at a time when. I thought that my nipples were falling off and breastfeeding has been a huge struggle for Jovian I because she has a tongue and lip tie, and now we're going to therapy and it's just her latch hasn't been Kirk. And so breastfeeding has been really really tough and and I knew it was going to be hard from hearing from other people. I, mean everybody that you talk to you thirds. It's not. Just, something that comes easily your babies learning you. You're learning your baby, your body has to make. Some changes and there's a lot that comes with it and so I knew that it wasn't gonNA come easy. But I wasn't prepared for dealing with an oversupply and a baby with the tongue and lip tie and just you know she was in the nick you for the first week so as pumping. and now. I feel like we're getting into a good routine and it's becoming a little less painful. But It was so good to hear the like hear her talk about. The Ben of the benefits of breast milk because. I know that there's those nights when you're exhausted and you're pumping or you're feeding and you're you want to give up and. I I had.

Rhonda Patrick Jamie Elizabeth Joy Kirk
"rhonda patrick" Discussed on The Joe Rogan Experience

The Joe Rogan Experience

09:45 min | 1 year ago

"rhonda patrick" Discussed on The Joe Rogan Experience

"You're not sleeping enough. You're not getting real sleep because you're constantly being woken up and shocked into the state of like no. It's really bad it's bad for you and it's bad for your spouse like my mother-in-law has to go. She goes into the guest room to sleep after they go to bed because she can't sleep like really bad. Do you have to do the the I wanted to kill the guy? You've no idea it was like I just stopped like having someone that's nores is like can't sleep. I can't wear my ears are like earplugs first of all. They're not comfortable for me. I've really tiny ear canals. And just like can't some people can sleep with your plug like I just can't just yeah. Snoring is a real issue and it's usually an issue of some sort of impeded airway. Yeah Yeah I'm glad I don't have that but the nightmare thing I'm just the melatonins helped so yeah hope you for sleeping. Oh I mean I think that going basically like having a good circadian rhythm and like bright light exposure in the early morning like it really does help like there was a time when I would you know like I lived in Oakland. I was just in this dark little apartment. And you know like it just wasn't really great for my circadian with him because I would wake up in the morning especially like on weekends and stuff like you know. There's no light coming in and I didn't I wasn't I didn't live in a place that was like I could just go outside. And frolic you know so frolic and Oakland don't really go But yeah bright light exposure. Big Too big. It was like a huge thing and the red light so I have. I do the Phillips you. Where like five o'clock all the lights in our house Go read dot makes a huge impact on my son and his sleep cycle like because Children are really sensitive to light because they don't have cataracts and stuff and so they're they're like you know the Melatonin is not being produced so Like if we go travel or go to my inlaws lights on. I'm like going around the house turning off 'cause I want my son to go to bed at an hour. You Watch do you if you're looking at your screens. Dis Blue Light blocking glasses. So I I have like all the APPS and stuff and most of the time like I turn my my. My phone screen is like down and they have black background and all that. But I don't wear glasses. I just those are great. You should look into the blue limelight because when I actually get a chance to watch. Tv like it. It doesn't happen much because right now my son falls asleep like nine and he wakes up at six and so like shoes. I go to bed really so I'm like wondering when do I. When can I cut the NAP? Out Like googling everything you know just trying to figure it all out so you have to keep napping until three I I gotta like decent more reading. Because it's not it's not uniform. I know my youngest. Never WanNa take naps. She's like fuck off staying awake. Oh my son doesn't WANNA take. He doesn't WanNA sleep ever wants to party all day every day man. He's like it'll start to see he's starts to get dusk and he's like it's still daytime time and I'm like for a little bit. It's GonNa be nighttime soon. What about if you get him? Active exercises yeah. Well it's we used to go to soccer class and stuff and go to the park but it's hard with the shelter in place right now. You pent up energy so we've been doing like yes so I've been trying to like take them you know like we do like hide and seek and run. Run run where where amount. But you know I think I think the bright light exposure for him taking him out in the morning is really important and now that we you now now. I'm able to do that more like I feel safer there so Especially being outside. I don't I'm not as concerned so like I think that's really important. From bright lead exposure is just. There's just study after study. Showing it sets your circadian clock boom. It's like okay. This is this is this is like the morning and your circadian clock starts and then you know so you become sleepy when you're supposed to come become sleepy as long as you're not in tons bright light at night But that's been probably the biggest thing by the way you know what's actually talking about. My Glucose Monitor my continues monitor. We're talking about popcorn and you know the biggest thing that really affected my glucose levels wasn't popcorn was actually lack of sleep really. Yeah big time effect like particularly if I wasn't exercising like like almost pre-diabetic level. Fasting Blood Glucose like when this is this is when my sleep was being disrupted when like my son was like younger. So I've been wearing. My Continuous Glucose Monitor for a year and a half. Maybe two years you wear this. What is it remind minds right here? Oh you have a little patch that you wear on all them. Yeah not diabetic. No love seen a guy who wears one of those but he's diabetic. Yeah I mean I'm wearing it because I'm sort of trying to understand how different foods have different lifestyle changes like. How long have you been wearing? I got it probably right after the last time I was on here. Okay right literally just constantly. Where for years and I've been where. Yeah it's been it's been almost maybe two years almost two years a year and a half but I most the time constantly whereas sometimes because it only it's like the central last for ten days after change it and sometimes I like forget and a couple of days ago bar and then I start like eating the pomegranate because my son loves and I'm wondering what does this do I click but the lack of sleep because he would wake up like I would be getting interrupted multiple times at night like you know where it was like. I don't know he was going through some developmental stage and stand in his crib. And it's like so I was. I was getting woken up multiple times at night for like prolonged periods. Jerry Very Lake Fragmented Sleep and I was nothing changed with my diet. And My Blood Glucose my my fasting blood glucose levels. If I'm might exercise routines dialed in. I'm not like shelter in place you know it's about you know mid eighties And so I was up like I was up to like lane. Fasting Blood Glucose would get up sometimes too like if I wouldn't exercise like one make wake up in the morning and I'm like one zero six seven one nine so big and it was capable. The lack of sleep causes you so many studies published. We did a video on it and like its defects like the insulin secretion sensitivity like all that stuff. It's all being affected. So it's one of the reasons why like shift shift workers like really are prone to type two diabetes. You really are phone so is so important. Poor people has got to be one of the worst things for your body. Nurses like their doctors. First responders anybody's working the late shift. Dan Dan had his appendix removed. Like he so he had this crazy story. But you probably have to go crazy. Is it? Well it's pretty crazy. Actually so he had this appendix thing happened. We were busily visiting his parents in Memphis and it was like Christmas Eve and so he had to go to the hospital. He was like the bad. I need to go to hospital so we went to the hospital. Like yeah you have appendicitis. But he didn't feel comfortable getting. It removed there because there was just a bunch of factors. That wasn't his doctor like up so he got this antibiotic treatment like sent home a couple of days later he got some treatment and then it came back like a couple of months later or a few months later back when we were home but he was like all of a sudden like the first time he had it. He was just like paying. I should go. Something's wrong the second time. He was like vomiting. And like you know. I didn't WanNa like my son was sleeping. It was like two in the morning. He woke me up so we call the I. I call the ambulance just like you know. He's vomiting know if ruptured because it can be serious but anyways these I my whole point was the first responders they came and they were just like yeah. We don't ever sleep like it's like we don't actually. It's just so awful for them. Terrible for you so anybody's working the late shift. God that's gotTa be so bad for you. I used to deliver newspapers so every morning. I was up at five o'clock in the morning and I was also doing comedy does going to bed really late at night and I was always tired. I just would be sitting here. I just fall asleep. That's awful terrible. A lot of a lot of people are sleep deprived a lot. Yeah A lot. Yeah it's huge factor. Yeah well I think we covered a lot today we got. We got a lot in the vitamin D. Information was so fascinating all of it appreciate you very much. You're always an awesome resource. Really Ain't you're awesome and talk to having me back on the Pike. My pleasure anytime. Tell people how to find. You found my fitness fitness tunes. Podcast as well as fitness youtube channel found my fitness website. Foundmyfitness had found my fitness instagram Alma. Fitness twitter all right. Thank you Ronda. Appreciate show by Buddy. Thank you friends for tuning into the show and thank you to our sponsors. Thank you to legalzoom whether you need a last will or a living trust or a advance health care directive. You can do it all legalzoom so many things that you would've normally had to go to a lawyer's office to take care of you can do online..

Melatonin Oakland soccer Phillips Foundmyfitness Dan Dan Jerry Memphis
"rhonda patrick" Discussed on The Joe Rogan Experience

The Joe Rogan Experience

12:30 min | 1 year ago

"rhonda patrick" Discussed on The Joe Rogan Experience

"'cause I have a few that I've tried from other the the tincture that I take from. Cbd MD and it doesn't get me high at all. But I've had some from other companies where I'd have like three drops full. Oh okay how does it help your sleep? Yes it is the. Thc is required to you know. Different people have different results when it comes to. Cbd and some people find that CBD with THC benefits them more and some people find that it's just the CBD itself but CBD. The company. That I use what I really like. Is They have a bunch of Muscle creams and like stuff. That you rub on the outside of sore muscles that's fantastic. It's really good pantries into the skin and just really good at alleviating soreness and I had so like one of my old colleagues science colleagues was That were measuring some samples from like different. Cbd products and like the majority of them didn't even have much CBD in them at all like. There's just a lot of I mean. I mean this has been shown with vitamin vitamin. You know vitamin supplements as well. There's been so many studies showing even vitamin D supplements. Like it'll say it has ten thousand I you but it only has like six thousand like there's been sampling where you like you go to like walgreens or CVs just whatever random place placing grab the vitamin that they don't have is the concentration in isn't high also those like ECHINACEA. Things like a lot of cloverleaf clover. Because it's not regulated kind of bullshit anyway. Like what does that do for you to Jack? Up Your Immune System. That's buddy always told me that they were all sick all the time. The people there terry interest in taking a fishing to know. I know I haven't looked into the ECHINACEA someone like someone asked me about. The elderberry So so I looked into that and because I was like is that like an ECHINACEA thing but and there's some actual legitimate research. Elderberry has been shown in randomized controlled trials to affect the immune system in lower colouration. And stuff like that you know so are you a fan of a fan of Kabukicho. Used to drink. What is the one I I drink the dark one? Ginger Lemon Darna can't remember the name. Um Tease no I used to. But then they're they are sugar that the sugar in that wants too much of the one that I drink is two grams per serving two servings. So there's only four grams of sugar. The sugar though is what helps the fermentation helps the fungus grow right. I think this is the. Gt1 had like eight grams so it was like twice as much and the other and the ginger lemon I like the Ginger Lemon Law and unlike this one tastes better so ginger lemon does the the one that I'm getting it's like it's founded like whole foods and sprouts and it's not the same amount of active culture though that's the question. I don't know it's in the dark bottle. You want home dark bottles better while the dark bottles better in life because it doesn't permit in the Sun as well doesn't the sun doesn't penetrate okay almost like uv protector got got microbiome. Health is important for function and it really is like like. That's another thing we're calling him. She loves love it do so I would. What's the brand I buy it? Buy It from sprouts or whole mother-in-law laws that we have some here. Yeah it's so delicious too and I love it with meet meet. We've we've been like we have a bunch of Elk Burger. We we ordered online ordering on. No no no no. I'll give you some here. We have we were like you early on. We were just like we freezers. I need to Burger. I need all the work. I'm just so thankful that it's not as bad. I mean I really am as well but I think our government needs to make an adjustment. They need to recognize that. It's not as bad as started opening things up but there's so many people that are just the sky's falling the sky's falling still. They're still saying there's still screaming from the rooftops we can people are dying. People are dying every day from everything that testing. I think that's GonNa make a big difference in become less scared as these as these therapeutics do March which which which they will. I'm sure absolutely but what I really wanted to talk to you. The reason why I wanted to bring you in here. Is this conversation that we just had to talk about. What are the? What are the methods that you can use to help boost your immune system? Keep your body healthy. I think we got it dialed in so vitamin D seems to be very critical sawn if you have it if you don't bath vitamin C. Orally you need a big dose and it's still not going to have the same effect if you can do ivy. You don't need to do but once a week and the zinc zinc let's Quercetin for your and then sleep sleep giant and Mike rebound health. Do you use anything to help you sleep in terms of like meditation. App or do you so I use Melatonin okay. Here's my way I used to not so. I have a history of night terrors. And well it's like when I when I'm stressed out particularly it flares up and it happens like when I think when I'm shifting from one sleep stage to the next where I am asleep but somehow I wake up but I'm not awake and I can still but I'm moving my body and I think that someone's in the room and that they're gonNA come get me and I flew out I scream and it's happened where I scare Dan. Of course he's like in the middle of sleep and it happens in my sleep cycle. So it's like but I've so I started doing. I started reading about this stuff. Like I don't want to like the treatments. Were like Ben's owes on my hell. No I'm not GonNa Take Ben's that's been shown to like cause dementia right so let's of terror terrible yes it. It's very addictive. And then like if you if you come into it I mean it can like you can like go through serious like die. Jordan Peterson just went through all this and literally. Yeah yes and went to Russia to have some sort of crazy medical detox awful. He's still suffering from it. I mean he's been fucked up for like a year. Wow that sucks so. I didn't WanNa do that but there was. There was some studies showing that high dose Melatonin. you know more in the ten milligram range sorry. I'm taking nine milligrams a night and I totally stop having for the most part dances. Yeah like I went through one episode where what happens when someone has a nightmare is like if someone else in the sharing the bed with you like tries to stop you or help like because I'm still asleep. I'm not aware that that's my husband doing that. And I really think someone's trying to get me so I just go into like crazy mode and I like I like somehow like crawled from our bedroom all the way out to the living room and by the time I woke up I mean I had bruised myself I was like how would I get out here. You know like this is like the worst. The worst. That's ever happened to me so usually I just scream and wake up and I think someone's going to get me. Melatonin totally totally stopped. It totally stops it. I measure I track my sleep as well and and I think that you know. I don't know the sleep stage stuff. How accurate that is. I think is very accurate but Duration is pretty accurate. So so what did not executive Tommy like how much time I'm in deep sleep are ordering. Oh that's accurate. I think that the I don't think the sleep stages accurate. Because like that's like you have to look measure brainwave like it's measuring. It's I'll tell you why because I've had multiple incidents when I was nursing my son back when I was nursing my son where he was on a nursing pillow and I'm very relaxed. Of course I'm nursing him right and making oxytocin and I'm like scrolling on my phone reading and it it calculated me as being Rem Sleep and it happened. It happened more than once. There's other times Dan and I don't we don't have a TV in our room bedroom. But when we go travel we're gonNA tell when bad sorely bad watching your show and I'm like totally relaxed in bed and it's totally putting me as calculating as asleep. The Mike you know calculates heart rate and movement And Body temperature. So you know I I like it I do I just. I don't think that it's totally accurate. And during my only real way to measure that. Is Those Little Suction Cup things you put on your head right. I did a sleep study I have sleep apnea so yeah so I had to do that. Do you. Do See papper. No I have a mouthpiece amazing yeah it's a mouthpiece because my father-in-law has apnea and there's a doctor. Dr Karachi and he's very wacky Guy Rope Ian Yeah missiles to write that down. Is that GONNA look them up? Yeah you can find it. Brian Caribbean knees in Tarzana. Yeah pretty sure isn't Tarzan. He used to be out here well. He was in Tarzana. And then I think you might have moved to Sherman Oaks. Anyway you'll find I'll find it all to you. But anyway he devised a mouthpiece it has like a little tongue oppressor and for me. My problem is my my neck is very thick. There it is what is a full breath. Solution C-PAP ALTERNATIVE DOT com. Yeah it's The idea is a lot of people. Have a problem with paps they. It's uncomfortable wearing your face. That's how I felt and so this mouthpiece asleep apnea mouthpieces. Sits in my mouth in the tongue oppressor keeps my tongue from sliding back and closing my airway. Wow so I I was okay. You did go on so I went in. I had a sleep study done. It was bad. It's hard to sleep. Probably when you're in those right like but I did sleep. You know because I was I was sleep deprived. That's what it looks like so see it sits in that little tongue thing pushes down on your your actual tongue was like they'd have to get fit like Yeah you go in there and mold exactly. Yeah it makes a big difference awesome. I've gone places and forgot it in a panic. Like fuck yeah So THAT'S A. That's a huge thing that I because I was like am. I just like freaking out because I'm like not getting enough oxygen or something. But they had me do a pull them or thing that lot of wrestlers and athletes football players. Get it because your neck muscles get really big and when neck muscles get big if you have a big tongue and I have a big tongue when I lay down at closes the airway so my tongue slide. Oh Yeah just associate with obesity. Yes well they get fat. That's one of the ways that they there's operations that they do to Try to alleviate it and they just cut out some of the tissue inside your mouth and then they also cut out your Boyd. Because I wouldn't be able to talk for like a month right if you don't wear. Do you snore? Oh a crazy that when you wear it. You don't snore. Yeah your wife must bub it before it was an also choke. I can't breathe you know because I am bodies forcing to adjust. I remember. I was on a plane once and there was this guy behind me news. A kind of a heavy fellow and he was He was really snoring loud. Who's laying on his back and really snoring loud and then he would go without breathing for multiple seconds and I filmed him and I. I told him when he woke up. I go hey man I go do you know you have sleep apnea. And he's like no go. Listen I haven't to I go. You got to do something about it. I go you hold your breath for long periods of time because really our show you. Yeah so I showed him. He's like fuck and I go. Yeah Dude this is really bad. It's associated with so many different things is associated with high blood pressure heart attacks the risk of all sorts of ailments. Plus.

CBD Melatonin Cbd MD Dan Mike soreness Ginger Lemon Law Jordan Peterson Tarzana Elk Burger Kabukicho Jack Russia obesity Ben
"rhonda patrick" Discussed on The Joe Rogan Experience

The Joe Rogan Experience

02:06 min | 1 year ago

"rhonda patrick" Discussed on The Joe Rogan Experience

"Like you know. There's there's homeo- static processes in these cells and stuff and so is it. Actually I was doing the sauna too hot at one point time. I was doing it at two hundred and ten degrees. Because of crazy layered laird. Hamilton had been convicted. That's nuts did I've done I haven't done. I have like I've I've been to to Rick Rubin's House and we've done like it was like two hundred and something barrels on their die talk but like I I was about to like go to one of his like literally going get on a plane and go to quiet and I'm like I'm doing this expertise thing I'm bringing my son. We're going to be a trip and this was happening in March Right when it all went down I was like okay one day one day Larry. We'll do one table do it. So he gets in over two hundred degrees with a fucking air bike with oven mitts on this crazy asshole is riding in air dynasty. And I say all with all due respect because I love the guy. But he's right. I hear them airtime machine in a fucking sauna bro. I so I did that. Two hundred I bet you because they liked you the same protocol and this was like two ten or twenty. It was so hot like like like I I was. I was like on some kind of mind altering drug show. Like and that's that's the point with those guys. The other thing that happens is and then we'd go into this ice bath and there's like this bath right outside and we're like did all this is and like. I said I was trying to impress. Rick Says Staying. Nice long as they could you back into the sauna and and like getting back into this two hundred ten or twenty degrees on and you feel like it's like room temperature because you were just in this ice bath. It's the weirdest feeling then you do that. Like we did it like three or four times. I don't remember but but I was like I started out the conversation. I was like he chopped proteins and I was like talking science and at the end of the conversation. I was just billing everything. Oh Look.

Rick Rubin Larry Hamilton
"rhonda patrick" Discussed on The Joe Rogan Experience

The Joe Rogan Experience

04:01 min | 1 year ago

"rhonda patrick" Discussed on The Joe Rogan Experience

"More often than the are in New York. We're tougher now clothes wearing t shirts. They're wearing shorts. You know you have more skin exposed. Someone might have done that study. I would like to see that study because it makes sense. Look and people are Shittier over there. Maybe that's why they're shittier. You know I mean. They're cold and grumpy Sure but also maybe that is not feeling well because vitamin D deficiency plays a factor in that as well and I would also like to see something done on whether or not that contributes to how many people get sick over there because when I lived in the East Coast when I lived in New York. Got Sick way more than get sick out here. I'M FOR SURE HEALTHIER. More cognizant definitely track think. All of those things player will personally. I think that you know that. There's been enough evidence showing that vitamin D plays a role in particular respiratory infections. I E PSYCHOSOCIAL STRESS STRESS. Cortisol like that that dampens the immune system. You know so when you are stressed. You're you're you're basically you're not in a good situation to to fight off as you were mentioning with your friend when you're stressed out like your immune system is is dampened and you're you're more susceptible to illness for sure and that's also that's also known. I think all those things and then the sleep the end. That's why it's so rough with all these people stuck inside and stressed out. You know all this. The financial pressures that people are experiencing right now because the lockdown. Yeah it's really it's so odd horror BIF- yeah. It is horrible horrible and start getting better. I hope I just hope. I hope that you know we can reopen the economy in a very safe manner where we don't have like flare ups that we don't want to be set back to like shelter in place again like full-on you know. I'm not GonNa do it again. I'm definitely not going to do it the way it was before. If it's the same disease. I don't think it's warranted. It doesn't make any sense to me. I not exhausted right. I think social distancing make sense I think sanitizing making sure you're using hand sanitizer and cleanliness and all that good stuff and if you want to wear a mask and public that make sense to okay. I get it but this was like inside when you're in places I think like if you're going grocery shopping yes sure but test people. How about that absolutely at work? I mean I test everyone that comes in here you. You told me he'd been tested. And I guess got tested again on Sunday at tested. An clear and I did that right when I got back from Jacksonville Florida. Even everybody's been tested. I'd like to get tested again. Just just for the fuck yeah. I'm hoping that the accuracy of the PCR tests improves. I don't you know I don't know if there's like a bet. You mentioned one test. That might be coming out. I hope that's the saliva but I don't you know I'm not sure. What factor do you think When we're talking about Saunas before one of the things. This is a respiratory disease and this is something where you're breathing in these particles and from what I understand. This is a vulnerable virus in terms of the the temperature that it can survive in. Obviously it's in your body but when if it's in your nostrils if it's respiratory tract and you're breathing in that heated sauna air. Does that have any effect at all on viruses? I think know that hasn't really been studied If the virus is like right in your nostrils I don't know maybe but I think it's already like getting it's already getting inside the the respiratory area like your body's kind of maintaining homeostasis so like the reveal retail some of it off and reduce the viral load. I don't I think I think you don't want to speculate. Well now. I think what's actually the sauna is actually. Just it's improving your immune system and I think that doing the sauna is making you more resilient against against infection like they're you know like like that's been shown there's been small trial showing that people doing Asana I forgot the the. But they're you know they. They were much less likely to.

New York vitamin D deficiency respiratory tract Cortisol East Coast Jacksonville Florida
"rhonda patrick" Discussed on The Joe Rogan Experience

The Joe Rogan Experience

10:33 min | 1 year ago

"rhonda patrick" Discussed on The Joe Rogan Experience

"Keep six feet of distance between you and those outside your household you fucking been doing comedy beds. Have you been? Were like start writing no no. I've written anything shed but I've been I've decided to just just except where this is and then when comedy clubs are about to open up then I'll start writing again but I'm just I mean just accepting where this is and I want to have an honest take on it. I don't WanNa be manufacturing a take. We're trying to come up with some sort of a hot take on how I feel but I wanna know how you feel about this and I really feel about. This is very different now versus the way it was in. March because in March I was concerned. I was like jeeze crisis. Could be terrible like we really have to stockpile food. We really have to make sure that we have water purification. We really have to be careful here. Now I'm like you gotta be careful. These fucking politicians. Now I'm in the place where you have to understand. These people people are starving. People don't have any money you're telling people can't go to work but you telling people that can go to work in some places like why is it okay to work at target but it's not okay to work in a family business. Why is it okay? Well let's let's figure out testing let's quarantine the people who are sick this strategy that you guys have you not adjusting adapting. You're not adjusting and adapting to the numbers mortality numbers too because their way lower than they were before push. Now we have this. Understanding of the ACE is symptomatic. People and how many people have tested positive? That are eysenck dramatic. It's off the charts. It somewhere in the range in in many studies seventy plus percent of people that getting contact with this are symptomatic test positive for the disease. That's crazy ASEM. Yes so that's the thing we gotta be careful about to be careful about forty fifty could be like. There's probably a range friends tire disease. It's out of their system. They never felt yeah. I have one friend who he did. He had tightness in his chest but he actually was in outside of Han in December so he was like got it at the time he just thought it was a little like whatever that's called tests. Yeah but it was mostly tightness. He said it wasn't like you know that's just crazy about this. It's so there's so many variables in terms of like how people how people are affected by it and what goes wrong. There are so many variables. Here's your your your genetics. There's immune system. How is your immune system shaped what your there's your diet that's included in your vitamin D status. You're you know there's there's you know the other interesting thing and and there's been no studies with SARS Cov too but there have been influenza studies showing that viral dose. It's really interesting studies. That have been done where I don't know who volunteers from these studies. But like sign me up to in. I want to be anyway. Louis Somehow get healthy people to do that and there's been these studies where people are like intranet inter nasal like they'll give them various tighter of influenza virus and they try the point of the study is to figure out what viral dose and they have some measurement like envy in tissue culture number or whatever and they found to make people have symptoms right and they found with influenza forgot which a or something I think one of the strains was like they could do a certain dose. I tend to the seven in Tissue Culture. Or whatever units were seventy percent of people would get like symptoms ranging from fever cough and all the influenza know flu symptoms but then when they went down to from ten to seven. Let's say they went down to ten to the five. Only ten percent of the people were getting so like. It's kind of interesting that viral does at least with influenza and there's actually been some other studies I think measles also that it is it is a thing not something that you wanna like. Go and experiment with yourself but you know that's another possibility right for sure we hear about nurses yes? They're getting way more sick right because there. I mean that could be one reason right there. Their actual job is to be around infected people in their intimating these people and their their h two can't practice getting writing their faces right but some of them. They have poor especially in the beginning. When you're seeing these people that were like using makeshift masks and jazz trying to horrible. Yeah I think with the masks you know for for people I mean reopening the economy and you know some places have been more successful you know even even Japan and stuff where you know the wearing the masks like the cloth. Mass doesn't do much to prevent you from breathing in maybe a respiratory droplet or something or aerosol that you know but it will prevent you from spreading it you know to to to a certain degree like. I get that people don't WanNa wear masks like it. Sucks like who you know who wants to wear a mask but maybe to open up the economy again like now? Maybe like everyone could wear a mask if they're going to be inside around a bunch of people either keeping the economy close keeping the economy close. I'll be willing to do. It's not gonNA be forever. It's not going to be forever because we're going to figure this stuff out. We are like it's already. We're already finding repurpose reputation. Monoclonal antibodies people working on. That's GONNA be coming soon. The monoclonal antibodies. So the whole point of that is that they're identifying antibodies that can neutralize the virus. And they're going to grow them and manufacture them and given people. It'll help treat eventually. They'll identify when that were kind of a time line. Do you think this. I think that I think things are going to think that these therapeutics can start the so like Jesse Beers already been identified and there may start to identify the ones like the pancreatic pancreatitis drug in Japan chemist. At something There's the Pepsi I mean there's a lot of different repurposing drugs that are being investigated You know and I think over the next couple of months and then general already. Doing one of these monoclonal antibodies. I think in the next couple of months We'll we'll have more therapeutics than we have Right now. At that that'll that'll make things. Less scary people will be less scared of getting sick because the have you know they'll have a better idea of. Oh we have some more. You know things that can therapeutically treat this successively. Hopefully people are going to start looking at the vitamin D. I really like I really hope that If not just I hope people are going to. You know take their vitamin D. Your doctor to take it. You know But Yeah I think then a couple of months. Can you wear a mask for a couple of months? And the. Here's why it's not gonNa work to just have the people that are vulnerable? Wear the mask because the cloth masks isn't going to prevent them from getting. You know aerosolize droppings. If you're spreading asymmetric which is that. It's been shown that you if you already some dramatic that CDC study. I mentioned a while ago. About how pre-symptomatic say symptomatic. After a week when they came back to measure the people again they found that out of the thirteen ten of them actually did get symptoms. The other three that were to matic had they were they were spreading. I'm sorry shedding as much virus That could make them. You know basically contagious and be able to transmit strain so the point is I think that I know. People don't wear mass. I have I have family members that like infringing their freedom you know and like it it does suck and I know people are were thing is like also children. I don't know how to tackle that issue because it's really hard. That's that seems a little more difficult but like adults you know you know. I think that if you're working when your your your restaurant back up your you know like that seems like a good compromise right. Doesn't the children with this disease because some children are getting sick? But it's a very small number but many children are getting in contact with his this disease and how many of them are a symptomatic but are spreading. So they've been. There have been quite a few studies looking at Children that are a symptomatic. Children that have mild symptoms and children that are symptomatic and So far so far the studies have shown For the most part that children even that are as symptomatic are shutting as much virus as both children that are symptomatic and adults. That are some dramatic meaning. They're like they're able to transmit it. They're shedding the virus. Right Sprinkler Systems. They are they're serling like I used to never get sick and then I became a mom and I think first of all the first year it hit me hard. Because I wasn't sleeping. You know because you have to like every three hours you gotta feed the baby giant. Factor immune system. Oh sleep is huge. We didn't talk about that. I know you've had walker on the hot item. I mean he's talked about it before and lots of other. Researchers have studied. This sleep is so important for immune function so important. I but I mean we're all not no one's working so they're probably getting more sleep now but they're also stressed out and they have anxiety particularly their bills are piling up and they have no income through. It's awful it's awful. It's awful awful for so many of these people that didn't do anything wrong. They didn't do anything wrong. Built a business and now that businesses crushed man. I think you gotta get the option. You gotTA give people the option to go to work you have to you. Can't you can't do this especially if it's an option but we're yeah? This is not the plague that we thought it was going to be. This is not the horrible tragedy. It's not it's definitely like Allegri with you on that like I think like a month and a half ago I mean I thought I was GONNA see body bags in the street. I was I was like this is GONNA be really bad. I was terrified and it thankfully has not been that bad. I mean New York City got hit pretty hard but you know. We've we have been on lockdown so that has to be accounted for you to see in New York City particularly when they were getting hit. You GotTa think this is New York City in January which is January. It's winter time. People are not going outdoors. I wonder how much the vitamin D deficiency varies dependent upon rights winter winter. It's been shut that it's been seasonal offensive showing that vitamin D levels are much lower in the wintertime. It also correlates. There's been studies correlating with seasonal affective disorder. And all that. But yes January all those vitamin D deficiency is lower for sure would like to see a study on whether or not it varies between the East Coast and the West Coast because over here. We do have all these sunny days outside far.

influenza New York City vitamin D deficiency Japan ACE fever Han Allegri Louis Pepsi Jesse Beers CDC serling walker East Coast West Coast
"rhonda patrick" Discussed on The Joe Rogan Experience

The Joe Rogan Experience

11:17 min | 1 year ago

"rhonda patrick" Discussed on The Joe Rogan Experience

"Like it's pretty intense like holding those positions and stuff like your heart rate does start to elevate. It's like just from that alone adding on the sauna which makes moderate physical activity. That's been shown absolutely mimics it and then all the studies have shown that on top of that. I mean that's like it's it's super intense. It's the the really cool thing about and I want to get my mom. I think we move on to our home where it's not like the office like I want to people that are not people that are sedentary and people that are sedentary for whatever reason maybe they're sedentary because they're disabled or maybe they're sedentary because they've had a lifetime of being sedentary and it's it is just hard to get them motivated to go exercise like this sauna to me is like that's so important because it's giving these people are potential cardiovascular workout. No it is. That's been shown it's giving them a cardio vascular workout without having to force them to go for a run are going down a bike that people think like when you tell them go sit in the sauna. They think of a SPA like I wanna go do that. You get someone who's like like my mom. She's she said in Teri. She's not like physically active person and she needs to be but like the Sauna. That's that's Kinda my goal is to get are doing and we'll have to start slowly because you have to adapt the heat shock proteins. Help with as you the more the more time you're exposed to heat stress and the more adapted you are like the the heat shock proteins increased quicker so it's part of the adoption process as well of you know being able to handle the heat stress but like. I want to get her to do that. Because like any you know any cardiovascular improvements can help her moods can help her her. All cause mortality. That's been shown you know four to seven times a week. Forty forty percent. Lower all cause mortality Cardiovascular mortality fifty percent lower. You know so i. I think that's a really cool thing about the sauna is that you can get people that are disabled people. That can't go for a run. You know I mean I still think exercise I mean that's the best thing ever period for everything you know for everything it's just gonNA overall improve the way you age. And that's GonNa make you more robust and resilient to anything sauna to me is it it. There's so many benefits but one of the big ones is that muscles feel better. They feel looser. They're not as sore like when I have hard workouts and I get in the Sauna afterwards. I feel like my recovery's more rapid interesting. That's interesting. Yeah I because I don't do resistance. Training Shame on me. I don't I don't have that same perspective but it there there have been studies at least. We're localized he. On people. That had limb mobilized. I don't remember what it was but after a week People that had the heat treatment local heat treatment had almost forty percent less muscle atrophy and in and huge in animal studies. And like I remember. I shared this animal. Study an article. I wrote years years ago. Before the human said he came out and like critics. It's animals and you can't say does this and I would get on the mechanism and they showed it with heat shock proteins. And there's all no like and I was so happy when he said he came out. Because I was like told you told you motherfucker. Say She was just a few of those. Those guys that you just like you like. Maybe just I don't know like do a big comprehensive search the literature and understand things and don't have that exact said he just yet but like. I know that it's going to help with muscle atrophy. So people love to dismiss things. Don't they yes they really do even even if they're wrong they just love to like fixate on confirmation bias a little possible potential things. Yeah so just being open minded and going I think that happens a lot too with like social media because like for if I share one study I'll share like an epidemiological study and it's like it's twitter. You know I'm doing one hundred and forty carrier or whatever the chain I don't know what the characters are now but I'm doing a small number of characters and I'm just sharing one study and if it happens to be a non randomized controlled trial you know correlation doesn't you know doesn't causation. It's like sometimes I just share a story because one. I think it's interesting or too because I've read a bunch of you know evidence surrounding this topic. You know about all the other clinical evidence all the genetic have all the animal like an and so I have a knowledge base here and so I share a study that maybe isolated in and of itself not the strongest study. But you know it's like Chandler comments. I can't someone else. This strike up a conversation in a Porta potty because it affects me like I'm the kind of person where I like to make people happy like it. It bothers me when people are like unhappy. It bothers me when people like. Don't go on twitter period because most people are unhappy or youtube. Now I mean I guess that's not really the case I for me at least the bigger audience that for you for sure. I mean the bigger your audiences. The more you get that. This is what I try to explain to a friend of mine who is on the podcast who read the comments and I go juice have to stop and think okay even if just one percent of all of my people that go from instagram. Like if you're reading the INSTAGRAM COMMENTS. One percent are assholes just want which is probably really conservative right? He had a room full of people. There's one hundred people in the room. What are the odds was going to be an asshole? It's one hundred percent right that means there's ninety two thousand assholes that's only untenable. You can't manage that right ninety. Two thousand shitheads who have fast their whole life and they wanna just beer Gary Barrett. They WANNA shoot people down make people feel bad. And just yeah. It's not worth it. I don't and I feel for those people I I genuinely. Do I feel for people that are in that state where they realize they're not they're not happy they're not happy with their own performance not happy with their life? They'd probably not happy with the relationship or the job and they just want to spew nonsense negative garbage. Yeah I mean that's that's the problem with not being suspicious delicious yeah tool cliff twenty five milligrams all right. Thank go get some other flavors to the the problem with that is. You'll fixate on. The one person says the negative exactly. It's a natural human inclination and that fixation for me keeps me up at night. I lay down. It doesn't happen much anymore because I try not to read of guns much better. Do you know what I'm talking about. The early days of social media before he got a handle on it. I'd be like fuck this stress like so taxing you get into discussions with people are like what am I doing? I think it's important to be critical and get like you know. There's there are people that are really trying to make prove something. And there's there's all sorts of incentives for being hypercritical if you had rational people who are kind folks who have interesting viewpoints and they looked at something and they found something to be wrong with that and they handled it with grace and some sort of Monica of dignity and kindness. That'd be great. I mean there. Are Those people sure like if you were having a discussion with a good friend and the good friend was looking at something he said and said I disagree because of this look I have conversations with good friends all the time even on the podcast where I disagree with them but we handle it like friends may but that's the problem with twitter's it. You don't see that person you don't you don't know them you don't. WanNa please them. He just want to be mean you know. And that's what a lot of people are doing just getting their rocks off there and I feel like now for while during the pandemic when it started. In the lockdown started people were nicer. There was less social justice. Outrage was less but now it seems like as time's gone on people getting more frustrated and more desperate and more depressed because they're locked up it seems like it's ramped up its talk. This is unprecedented right. Being it is I I miss miss my life before the pandemic ms taking my son to the park and miss our our soccer classes and music classes. I miss it. It is hard. Kids are having drive by birthday parties. They drive by with fucking balloons yell at the window. Happy Birthday like fuck. And they're never GONNA forget this. Then they're going to get a weird. This is to do an alter their classrooms on ipads. This is so weird. See My son's at an age. Where he's this. He's not going to really remember. Well I mean depending I. I really think that I think things will start. We'll start to get better. Well it's the dozen. I'M GONNA move to place where it's better because I think the way this co- this state is handling in his fucking terrible. They're treating us like we're infants. Some of the list. They've given you a proven activities and Nana proven activities. That's highlighted for me because I don't know if you've seen having I didn't even know that pull pulled up Jamie there so fucking stupid because you gotta realize these people that are writing these lists. These are not experts. These are bureaucrats. These are politicians. These are people that really have no business telling you what to do and what not to do. They're fools but they're in a position to influence millions and millions of people so they have the ability to tell forty million people what they can and can't to make the largest secondary this look at this athletics badminton singles throwing a baseball softball. Bmx writing canoeing singles. Crabbing you know crabbing. You'll find crabs cycling exploring rock pools. Oh Can I can exploit rock pools you fucks gardening not in groups golf singles walking no cart. Why why can't I take my car? Who are you well? Hiking trails paths allowing distancing horseriding singles. Jogging running it gets gets grosser meditation. Oh you can do outdoor photography. I didn't know thought that GONNA kill everybody. What is what is what is the top of this. What this headline. What is this page outdoor activities? It gets worse? Kids scroll down. It gets so stupid towards the end. Soft Martial Arts Tai Chi Kung not in groups cheek hung they listed the martial arts like fuck off table tennis singles trail running trampolining. Oh can I get a trampoline? Thanks did know how about this one? Watch the sunrise or sunset. How about wash the car? Wash the car. Oh Great. That's something I thought. Rocks reform from the fucking sky. And I couldn't wash the car. Jesus Christ but that's what drives me bonkers in all cases you should only do these activities alone or with members of your household..

twitter muscle atrophy Martial Arts Tai Chi Kung Gary Barrett soccer Chandler Monica baseball Jamie Bmx softball
"rhonda patrick" Discussed on The Joe Rogan Experience

The Joe Rogan Experience

03:49 min | 1 year ago

"rhonda patrick" Discussed on The Joe Rogan Experience

"Like the only the only really choice if you don't have the hot Donna and our homes on it. What About Coal Chuck Proteins? And the I mean how much difference between taking a really cold shower ice bath versus Kreil cryotherapy the place that I took you to. Yeah so I mean there's there's differences in I mean so it depends on how long you're staying in a cold water cold shower like actually being submerged from if you're making the ocean or something or lake and you're like from your shoulders down like that's probably much more powerful than just having the shower on but by the way the shower like some days. I'm like matter this. This is not cold at all. You know it's just so variable whereas you like southern southern California live on the border of Mexico yesterday so so so most of the time now show right after saw like my shower time now and so like I. It's I do about six minutes and it's so easy for me I totally have adapted and I'm not sure if I've just totally adapted or if it's just like my faucets isn't it just doesn't get cold out cold. I really doesn't Today I took a cold shower From home and my son is not there and I did just because I wanted to. Have the mood affects north and effort. And that's been shown to be increased And it was much colder but then again it was a different shower. I'm not sure if it's because I didn't have the hot before you know beforehand like the huffing hot and getting the cold shower like it just feels really shock but the culture shock. You asked me coach the that that hasn't really been measured in humans Is Measured Most? The time with culture is norepinephrine release and we're friend in plasma and there has been studies correlating nor up in plasma upon cold exposure norepinephrine release and plasma to In the brain where it's involved with like mood and focusing attention so there's been studies where like you do a two minute cry. Oh whatever the average temperature it's really cold minus two forty s Yeah and then that could be compared to like you know a longer. A longer duration degree I think fifty degree Fahrenheit water or something like that. I don't remember the exact time but but it is comparable but you have to stay in a longer duration so some people prefer ice baths. Some athletes prefer the ice bath versus cryotherapy. Even though it's probably more painful because it lasts a lot longer. Have you done those? I've done it. I've cry the so I've have you ever done the cold shower after your sauna. Yes do you like like it a lot like it particularly after hot? Yoga after after hot. Yoga is especially in the winter when it's actually cold the water's cold. That's what I love it. There's something mood enhancing. I mean these things also affect the immune system but also very relevant both cold and hot they both have been shown to increase lymphocyte numbers and also like other milot cells and stuff and people. But but like there's something like I've done the sauna and then gone into an ice bath and then you know it's just really hard. It's cold I mean you feel good but man you know. I think just like the guy's house I was doing and I was trying to impress them so you know I'm hardcore this but it was. It was pretty intense. I do I do want to get some kind of like they have those like ice baths that you can like regulate regulate the water temperature ones that you plug in. They're not ice baths Litas cooled like yeah. We wanted to get one here. We're probably GONNA wind up doing that. Get one here because showers and the shower Nickson as kind of useless to who uses the here. Jamie just me. You don't use. The Sauna is occasionally occasion. Yeah I also had a gym. I was going to you. Do use the that right. Yeah.

Kreil Donna Jamie California Mexico
"rhonda patrick" Discussed on The Joe Rogan Experience

The Joe Rogan Experience

12:31 min | 1 year ago

"rhonda patrick" Discussed on The Joe Rogan Experience

"One hundred eighty degrees for twenty five minutes dude. I do one hundred and eighty degrees for twenty five minutes. Who'd unless it's one hundred and ninety one hundred eighty eight then? I'll do twenty but yeah I do twenty five at one hundred and eighty so seems to me. The sweet spot. You know. I've been doing it every single day of the quarantine because I have a son in my house. Do you have on in your house. We were in our office just home off. It's like it's like well. It's not in our home but it's yeah just next door so we've got that literally you're not gonNA believe this like like three hours before shelter in place was putting putting California. I mean I couldn't believe it. Well we we had ours done just a few months before I mean it was just. I was thinking God if we didn't have this in the house and you couldn't go anywhere. Luckily we have one here so I could use the one this year. But it's a godsend manages. Everything's a game changer. It's a game changer. And I've been doing so I haven't had a warm shower sense since the shelter in place since I got my I I. It's amazing like I do. I don't want to make people feel bad. Look I went a long time without Asana. I know what it's like. I was doing hot baths and we can talk about. It is but there is something about the sauna and the cold bath the culture. Sorry the cold shower that is just it is game like I'm so much more relaxed and this is like I think I've told you the story. The whole reason I got interested in the sauna was because I was graduate school doing it like every day and I was like this is amazing. I am so much less stressed. I am like calmer more relaxing. I'm your something's happening so I was like into the not. Even all the muscle and all the cardiovascular mimics cardiovascular exercise really has a big difference in my cardiovascular activity it's been shown to New People. There's a study this was I think very loukine. And WHO's a friend of mine? Just he's like the best the leader and Santa Research and Finland. He published a study where they looked at Cardiorespiratory fitness and Cardio I think Cardi other cardiovascular disease risk markers in people that were physically fit physics. Sorry physically active plus the sauna or just physically active. So so phys ed just on a alone. So physical activity was like the king so like if you compare physical activity alone to Sano alone. Physical activities the best improving cardiovascular health saunas also good sauna and physical activity together. We're better than the physical activity alone which I was like yet. That's what you want. I don't remember that was like you're you're asking me like six months ago or more but that's what you want right like you want like you like. I'm already physically active. You're more physically active than me. And so but that's what you want is like the combination makes a big difference. Once I started doing during the lockdown one of the things I noticed the runs that do the last hill is fucking brutal and I always finish on this last hill but now I've been able to run that last hill the last hill. It's like a market difference when I hit the hill. I'm like wow. This is crazy either. I'm getting better shape and I know I am for sure but it's also I gotta think the Sauna has a big impact because it feels like I'm on a drug. It feels like I'm on. I don't know what he feels like. But I would imagine it would feel something like this increased. Cardiovascular benefit is very noticeable totally totally. I mean there's been some small studies looking at. You're talking about performance enhancements. There's been some small studies showing that particularly with endurance. That there is a performance enhancement. I think it was cycler. Maybe it was running running and cycling. Never measured your heart rate during it so yes. So here's the thing with that like at first. I was like terrified to do that. Because I didn't want to ruin my apple watch you like ruined her and like Kevin Kevin Rose was like no. Just put your hand on. I do all the time and like like he's the Tech Guy. So I'm like Kevin Rose tells me I can take my Apple Watch hot frigging. Casanova do it right so you know my heart rate it it can get up to like one twenty but the thing is is that there is adaptation. That happens. So you're basically like you. You're you're becoming adopted and so your heart rate doesn't increase as much like over time and I'll be I'll be honest. I stopped wearing my watching there so not measuring my heart rate anymore. Together whoops trap. The trap was no problem at all. Yeah The H. O. P. One I'll have one sent to you all right there. One of the sponsors the podcast but I love it. I would love to have something to measure it without having to take my watching there because I don't like setting like it's the measures it really well and it'll give you could actually market down as an activity and show you where your heart rate's. You had a mountain of data. It's really good cool. Yeah let me I also great for sleep shows. You like really accurate sleep. It actually has a sleep. Coach built in so it shows you. How much sleep you got. How much recovery. Recovery's out and what you need and it'll even tell you you know. Hey you should go to bed since you beginning up at six o'clock in the morning you should by ten tonight Nice. Have you noticed in effect? So I've been doing this on a everyday starting as a week because I would do it every day but I got to have more time with my son but have you noticed an effect on your sleep at all relaxed deal. You need more sleep like you know like when you're working out hard like sometimes require lake more more sleep. Yeah yeah boy when I do squats for sure anytime. We do lunges and squats heavy leg days. I'm Zombie for two days. And like if I have a particularly intellectually challenging podcast. I'll skip leg days because I know I'm just going to be too stupid. I've done it before. Coming to my. I can't form weird's what's not if you see what I'm doing this weird. There is a study that linked on there was a link between like leg strength and cognitive function. As very strong like the more strength you had like the improve. It was like some kind of crazy number two. Yeah it just makes sense that if you have more legs strength that means you're doing more activity that means you get more blood flow that means you. Everything's probably because it's such an enormous part of your body when you look at your musculature. The large percentage of it is from the waist down. And when I do When I'm doing legwork like doing most of what I'm doing is kettlebells but I'm doing lunges and presses squats and all these different things with heavy kettlebells. So it's like a lot of weight that your muscles are pushing. Dan Is always trying to get me to do squats. Like I don't know what backing when I was in Grad School is doing squads and I was using the stuff and then I was doing. I guess what are they called Lake presses? Yeah and I like injured myself and in this Scottish Cup. What's the other one that's like Skydeck? There's another atticus is a nerve that comes from your is like right here. Yes well you know what from though. I don't know what I I don't know what it is calling bull SCIATICA. Most of the time. What you're getting is your lower back. You're having your disks or protruding and your disk herniation of the disc or if you have a bulging disc it's pushing against your nerve and that's sending that pain down usually your but in India back your leg in along those lines right. Is that what you were getting paid? Only it doesn't go into my leg. It's just like this like right. Yeah Yeah Yeah that's it. That's a lot of times you think it's that area but it's not it's your back and it's your back with the disc pushing into the nerves. Have you had an MRI? Now you should have an MRI. Because I'm here to squat. Looks like every time I do that I get a flare up and it's like I'm sure amount. Well there's other things you can do to strengthen that area but first of all there's a machine called reverse hyper it's fantastic. We're I hyper out outside. I'll show it to you but it was created by this guy. Louis Simmons from Westside Barbell. He's a he's a genius he's given US A. He gave us new platform to. It's amazing to what does that think call. Jamie it belt. Squat Belt Squat. I love this thing because you wear a belt and the wait is actually pull the weight behind you. I'll show how how it works before but you're on this platform and all the weight is on this belt instead of on your shoulders so you can have like two hundred and fifty pounds or whatever it is but it's all being carried see. That's that's the thing right there the machine but that's yeah that's similar to what we have but the machine that we have is a little bit more complicated but the point is this guy comes out in pictures of females doing only guerrillas big giant youth. But the the reverse hyper the reason why it's so special is forget about this. For a second hand there's a girl using that That is more primitive version. The one that we have out there the new one that Westside Barbell Cintos is just a cable to come to the floor and the weights are actually behind you and it carries you carrying all the weight on your hips with strengthens the legs without putting a load on the back. Which is fantastic. I like that for that. So you can get all the legwork. You get from squats. But you don't get the pressure on the disks and then the reverse hyper is machine that he actually invented Lou. Simmons invented it because he had a herniated disk and the doctors are telling them. Hey we have to operate on you because you have this compressed disk and so he's a very smart guy and he knows so much about physical fitness and weight training hit. That's Louis Right. There he came up with this machine so he said well listen if if something compressed something can decompress it so he came up with this machine. This machine reverse hyper does on the lift. Its strengthening the lower back muscles. But then as you drop it down it's swings low and it actively de compresses of your disks. Wow be so scared that's GonNa aggravate you. Trust me first of all you can do it with no wait the first you can do it at first with no wait. And that's a lot people are when I introduce people to have. I do no wait but for me. It's been a giant game changer. So I do that. And then there's another thing by teeter teeter makes his decompression decks. It's called the DAX ex and from that you hang from the waist you like strap your I have that outside as well you strap your ankles into it and you hang from the ways. And it just all your. That's there so with that. That lady right there in that image. She's holding onto those handles. And that's how you get yourself down but once you get yourself down you just relax and all of your weight other guys doing it. They're all your weight is decompressing the spine so it stretches a spine out decompress it and it gives you a lot of relief so between those two particular pieces of equipment the reverse hyper and this decks to which which I fucking love that thing yeah. Dax too and that's when I get home gym. Yeah that's made by teeter. Teeter has two things that are really cool. It has those inversion tables which are great for you. Know the same thing you're hanging by your ankles and it's decompressing spine but I actually prefer this product from them because this completely isolates lays the back and you're not pulling on your knees and your ankles when you're decompressing it's all just decompressing the back and also you can do leg extensions and a bunch of you see people doing dips and other exercises from the The teeter but it's a great machine and it's just really specifically good for back. Health lower back health decompressing in and even strengthening it. Because you can do those back extensions so you hook yourself into it and you just lift your scared to do. But it shouldn't be. It shouldn't be scared to do it. Because that's what's going to protect. That area was going to protect that areas muscle and strength and also flexibility. That would be just incredible guarantee you. It's GonNa work because I'm so like the whole time. I had a gym membership. Or It's been like on Pas but the whole reason my head one sonnet. I'm scared to do like I do free. Weights free weights. And I'll do that but like I'm just scared of machines that get you a trainer. That's what I need to need. Because so many people fucked themselves up trying to do things on their own did and now..

Teeter Louis Simmons Kevin Kevin Rose California SCIATICA Louis Right Finland Sano Lake presses India Westside Barbell Cintos Dax Santa Research apple Casanova Grad School Scottish Cup Dan
"rhonda patrick" Discussed on The Joe Rogan Experience

The Joe Rogan Experience

09:48 min | 1 year ago

"rhonda patrick" Discussed on The Joe Rogan Experience

"The pharmacy kinetic data where it was like. No it's not the same thing like you're talking about seventy times higher vitamin C. LEVELS IN THE PLASMA. Like you could never do that from oral like it's not the same at all and before that was known. I guess maybe that that's why I've even heard people dismiss vitamin C saying that. Your body absorbs a certain amount. It's wasted if you take more than you. So here's the thing like so so maximum bioavailability does occur at two hundred milligrams and once you go above that like when you if you take five hundred milligrams of vitamin C early. You start to excrete a lot in urine. But that doesn't if you look at the plasma levels you're still increasing them much higher excreting more to but you're you're increasing your plasma levels more so you so you take hundred. Milligrams you get your plasma levels of Vitamin C. Up to ninety you take five hundred. You may get a little bit more. You take three grams. You get it to to twenty. You'RE GONNA be paying a lot out but you've got to twenty right and so if you look at these. These common colds studies. There's like randomize analysis randomized control trials Manassas. They've shown that like two grams is better than one. Gram for for Reducing the duration of the common cold Two grams better than one and Children who are more have more robust and adults alike. Adults like it reduces the common cold. Two grams can do something like twenty research. Ration- belly twenty percent or something and it's emergency. That company got a lot of Shit for their claims. The I to Graham emergency doesn't have laughing so so then you a two hundred milligrams or so there you go you keep looking down. There's more Meta analysis another Meta analysis that looked at two hundred milligrams up to two hundred milligrams up to two grams and that study. Kinda just lump everything together rather than the other. Study like okay. What happens is two grams in one? They did all the analysis and that was great because they got to the bottom of it dose matters the study it was like oh it. It reduces the duration by like four percent. Basically nothing so so. There's like all this. There was all these conclusions. It doesn't do anything well. Yeah two hundred. Milligrams look at that. Graph does it doesn't shit to your plasma levels like you're still at baseline so I think that people designing clinical studies like they need that needs to be in their mind before they design their trial. Okay what am I trying to measure here like I want to get? I need to like. I need a measurable like I need something to measure. And you've got to change right to get an outcome like if you want your trying to see what effect vitamin C has on whatever outcome. You'RE GONNA WANNA wait ray someone's plasma levels right so I guess it's good at the end of the day to know that two hundred milligrams doesn't do anything because then you go okay. Well two hundred milligrams doesn't do anything but it's also good to know that. Oh wait I take a higher dose. There isn't effect. So you know making this general statement. Oh Vitamin C. Supplementation doesn't do. Anything is not necessarily accurate in some respects. Yeah two hundred milligrams. It doesn't do much for the common cold but when you take two grams it can help and also other studies have shown that prophylactically you slightly better than like therapeutic like after the onset of symptoms. So if you do it like before symptoms like there's a better outcome as well so I mean that's all kinds of interesting so for you personally. If you had the option would you do it once a week? Iv I'm it's pretty interesting I've like I was doing it. I was actually doing it once a week before plano. Once a week is enough totally. I don't even know if it's necessary honestly on to be honest because again. It's a therapeutic treatment. I will say this like my one of my friends. She's a she's an MD and she has reactive. Airways there's interesting studies that have shown that intravenous vitamin C is like dramatically reducing inflammation as well. It's doing all kinds of crazy things but her cough and it was very transient. It only happened like while the vitamin C was high in her plasma. She's got this crazy Commun- you'd think she'd had co like. It's just like an constant nagging cough. You know that it completely one hundred percent one away I noticed it and she lick. My friend is a little bit. You know she's a little bit of a skeptic when it comes to vitamins or anything like that you know so I wasn't GonNa say anything because her and I have gone in so many debates about it so But she said something and I was just like you know I'm so glad. And so she now. She's wanting to do it like she's wanting to do like you know once a month at least so So I thought that was interesting again. I don't know that the intravenous vitamin C. is necessary. There's also interesting effects on like fat. Oxidation legal affects fat oxidation. Because it's important for carnitine which is an necessary for oxidizing fat like there's been clinical studies where people are like burning fat when they're exercising if they have vitamin C if they have low bottom in sea levels or not like burns much fat. It's because it's the CARNITINE. I thought that was really interesting. I didn't know anything about that. So we've been doing intravenous vitamin C. And Glutathione and a bunch of other stuff zinc once a week. That's we've been okay. Yeah another one. That's really important for immune function as well. An elderly people are more sink. Deficiencies not really common in the US. Most is found in really high noise tres. But not a lot of people oyster that meat poultry. You know if you if you eat enough of that. You should be getting enough thing. Overturns Vegetarians do they? They are more prone to zinc deficiency and in fact because the zinc is bound to Fi- tate. It's less bioavailable when they need to like eat like up to three times more. Rda needs to be like almost three times as high for them or they can just supplement which. I know a lot of Vegetarian. Do but yeah but zinc zinc's really important for function like there's been studies where they've depleted healthy people of zinc just transient and Like t cell function lake is all messed up so at lake totally messes the immune system up Randomized controlled trial showing the zinc zinc acetate or zinc glue. Khanate like lozenges They can Dramatically lower the duration of common cold is Acetate or glutamate which one superior so there was like. It was trending. That acetate was better. Trending meaning was nonsignificant Although it was like forty percent or twenty eight percent. I don't like I to me. Lowering and lowering the duration of the common cold by forty percent versus lowering it by twenty eight percent. I guess it was significant for whatever reason so there. It's the study concluded that they're both the same. Seems as though Acetate. Slightly better Baby slightly better But you know I am. Taking zinc is also a positive ion. So you need as INC for to help get in to cells So like course flavonoids. Quercetin quercetin found in lake apples onions. Buckwheat tease which is what I drink but you can supplement with which I also supplement as well. It's Questions interesting because a four. It's also been identified to have activity against SARS cove one antiviral activity against harsh cope one neutral properties as well. I don't know wrong. Has Emergency confusing it with something? It's got thin Olympic properties. Which means it can. It's been shown it's been identified as a possible compound that can clear out sin senescent cells. Which are those cells that are you know they keep with age? And they're basically like they're not dead but they are just like not really functioning and their secreting their secreting cytokines and things that age nearby cells. I always like to think of like as mentioning to Jamie that Maybe forty two next month and so yeah I have some great grey hairs and it's funny how you'll get one gray hair. And the other Gra. Here's a cluster around that one clustering and I always think of like because their cellular. Senescence happens in the MELENA sites. The are responsible for pigment. Say I always think about. Oh the senescent. Milan is creating all this pro inflammatory stuff. That's now accelerating the age my other nearby hair follicle causing them to anyways. Quercetin identified to clear away. So that's kind of cool for aging freighter hairs and I'll just for aging. That's just my lake and analogy for people to understand why senescent cells are bad because they leg age other nearby cells by secreting. All this stuff pro inflammatory things I forgot to ask you about vitamin D deficiency is red. Light therapy what would that have to do with vitamin D? I don't know. Do you know about these red light machines that people stand in front of the photo. Bottom photo bio modulation. Does that have any effect on vitamin D? That's not you know different. Yeah Yeah and I think that that itself it. It's an interesting field I would say that it's the marketings got a little head of a science for that but I do think that there's there's promised particularly for some Treatments you know there. There are some claims out there that are Sort of being backed up by very poorly done studies but I think I think there's some promise out there for it just makes you feel does it. Yeah it's interesting. I've been doing it I try. I wanted to do it before I even talked about it for months solid and I'd do it basically four or five days a week and I just. I don't know it's hard to tell because I do so much shit do you..

vitamin D deficiency zinc deficiency carnitine colds cough US Graham plano MD Rda MELENA Fi- tate Jamie INC Milan
"rhonda patrick" Discussed on The Joe Rogan Experience

The Joe Rogan Experience

13:39 min | 1 year ago

"rhonda patrick" Discussed on The Joe Rogan Experience

"Also be that SARS Cov one and it's involved with clotting so having lower levels may somehow even help protect against that's a theory it hasn't been shown but What is known is that people will typo. Blood are are less susceptible to contracting Copa Nineteen. That's that's definitely known But I mean I think there's so many things just there's so many factors that a lot of data needs to be passed out for sure I mean a lot of data that means progress out a lot of data that needs to be generated. And you know. We need higher quality data. We need know people to repeat stuff. I mean. Look what's happened with this hydroxy chloroquine stuff right. I mean I mean. It's just kind of a mess. Where initially it seemed like could be helpful and and then just more and more studies came out where it was not knowing not helpful it. Was You know? Toxic IS CAUSING. People tap dangerous arrhythmias and stuff you know. So that's that's kind of the the reason to be cautious when when you have something new and a small one small study like in the beginning. At least they're trying to figure out what the correct treatment for these people as they were just showing up in mass in the emergency rooms and they didn't really doctors they varied in how they approached it. My Friend Michael. His doctor didn't put on a ventilator and he said if I put him on a ventilator he's probably going to die right because he said his body is going to stop working. Because it's it's GonNa let the ventilator do the breathing forum it's going to give up and when he was talking about After the fact would Michael's talking about was how that is proven to be correct in New York and that some monstrous number like eighty percent of the bureau put on ventilators wind up. Not Just New York. I like a life had friends that are physicians. That have like you know in New Orleans. I mean same thing where it's like you know I. There was someone on my team. We were looking. We were doing some research on this and I didn't sort of dive into the whole thing but he was he was telling me that Ventilators do actually like cause more damage to the like like. He'd been reading some studies to confirm that and he was pretty certain that that ventilators actually caused damage in actually could like induced damage. Where it's like making it worse. So that's so specific all I know. Is that it it looking at the statistics. Like if you go on a ventilator and surely it seems like the outcomes not very. It doesn't seem like it's going to be very good but it's hard to say is that the cause of it or is a right there so fucked up by the time they get on a ventilator one of dying right well here. The there's been some really interesting data looking at like in the Philippines and Indonesia else nor I think New Orleans as well. They've looked at patients that have died and their vitamin D levels and in basically like in the Philippines you know people that for like every standard deviation increase in vitamin D levels serum vitamin D levels. You know the people had like an eight percent or eightfold eight times less likely to have a severe form of Cobra nineteen and if they had and they were twenty times less likely to have critical light critic critical form of cove nineteen In the in the Philippines in the Indonesia was a really interesting study where like they measured vitamin D and this was measured in the patients. There's been some vitamin D studies. Also were there like looking at you know countries that have been affected the worse and they all like have low vitamin D. And it's like okay well anyways that's correlation but also this but a little. It's a little stronger data. The in the in Indonesia patients that died ninety almost one hundred percent. It was ninety eight point something percent of patients that died with Kobe. Nineteen we're vitamin D deficient four percent of patients that died from covert nineteen. We're vitamin D selfish. Four percent only four percent. We're fight vitamin D sufficient. So basically they're all vitamin D deficient. That are dying go crazy right and New Orleans had some crazy crazy number. Be The mechanism that would cause so. I think there's all right can we? Can we get into vitamins? It's a big. I really think of you. I take five thousand a day awesome right now. I'm taking five thousand dollars a day. you know. Seventy percent of the population has insufficient vitamin D levels which is considered less than blood levels less than thirty milligrams nanograms per milliliter. Something that you your body can generate naturally if you're exposed to on a daily basis. Yes that's the best way to get. It is but the problem is is that we don't go outside anymore and you don't exactly now more than ever terrible recipe right vitamin D deficiency is. What makes it worse and then you're staying inside. You're not getting any vitamin D. Yeah you're becoming even more deficient you know like like somewhere like twenty eight percent of the. Us population is actually deficient like less than twenty nanograms per mil. That's defined deficiency. So there's a lot of in the United States As you mentioned you make it from the Sun so particularly UV radiation. There's a reason why I want to talk about this You make it from radiation exposure. You know basically you're it's made in the skin and But you know there are certain times of the year depending on where you live and more northern latitude where you've isn't even hitting the atmosphere making vitamin D. Also if you have darker skin Melanin protects you like the whole you know people. With darker skin people From Africa or India or South Asia the more equatorial regions there. Closer closer to to to the equator. And there's more UV radiation throughout the year and so as a protective mechanism to not get burned. You Have Melanin which protects you right. The problem is is that Melanin also blocks your your ability to produce vitamin D. But if you're out in the sun all the time you know in a place where you're getting radiation. It's not a problem. Well this is the very reason why people in places like Scotland and England have such pale skin exactly cloudy all the time so your body sort of develops its own ability to absorb more vitamins. Xactly so what happens when you take what happens when you take a person from from South Asia from India from Africa and you put them in Sweden or in Minnesota or in the UK and a place where you've radiation doesn't hit most of the year and you don't give them a supplement what happens is they become severely vitamin D deficient severely. And what happens when you take? You can throw this on the you can flip. Flip this over and say okay. What happens when you take the guy from the UK the Brit and put them in Australia like without any sunscreen without a hat? Yeah so I mean. Do you think that this could be a factor in why so? Many African Americans are getting hit so far. So here's the thing so African Americans. There's lots of African Americans are are are in the United States. There's been studies. African Americans are severely deficient there twenty eight times more deficient in vitamin D than than Caucasians. And it's it's it's because it's because they have darker skin and they're not getting an upset because people stay inside more people. Stay inside you know. It's not it's not like the old days when we were out. Hunter Gatherer and out in the sun all the time where we're inside all the time we're in school. We're working officer cubicle So the CDC. Obviously there's been studies showing that African Americans are more hit but they didn't really correct for tons of lake other factors. 'cause socioeconomic status is important hell other health factors you know and But there was a big city just released not long ago from from Lake the National Office of Statistics in Britain. Or something like that. I don't know what their official name was. But they released Some statistics from England and Wales and the I don't know what the correct name to say. I mean the blacks. They're basically living in England and Wales are four times more likely to die of cove nineteen than than whites when they when they adjusted all that data for socioeconomic status and other health factors. There were two times more likely to die so clearly socioeconomic status and other health factors are playing a role but through something else unidentified and I think it's Vitamin D. I think that you know. So you know the vitamin D like it hasn't the vitamin. I'M NOT SAYING THAT. Vitamin D is going to prevent you from getting covert nineteen or its treatment although I am involved in a clinical study where we're GONNA BE TESTING US. Very Small Open Arms Study. We can talk about but you know. I'm not a physician and medical doctor. I've never intimated anyone Said don't think I'm saying that I don't want people thinking it's a treatment I just want to. It's a hypothesis that needs to be tested and thankfully there are clinical. Trials randomized controls that are now ongoing and there some that are recruiting justice. Statistics that you've already listed about vitamin D and The people who had covert nineteen. Those are saying it's and also in Sweden there's a huge population of Somalis that have migrated to Sweden and they have been identified as being severely vitamin D deficient because a lot of the Somali off. The also like like autism rates are really high there. And there's this link between published golf that between Vitamin D and autism. But so there's been studies looking at vitamin D levels in the population. I mean they're are so deficient because you're taking again. You're taking someone WHO's supposed to be. Who's evolved to be getting a lot of Sun but not burn from it and then and then putting them in a place where they can't get any vitamin D from the sun and if they don't get a supplement like they're going to be deficient so much more they're like it's wreaking havoc in Sweden on this. Molly population is so logical. Yeah it's it's and then okay so elderly elderly are like insanely more deficient. Forgot the exact number obese also obese. People are like three times more likely to be but I mean deficient in the United States because vitamin D is a fat soluble vitamin. And it's less. It's been shown to be fifty percent less bioavailable. So you have to after you make it in your skin it's stored in fat and released and when you know basically into the bloodstream and then it can gets converted into a hormone. This hormone regulates five percent more than five percent of the human protein encoded human genome. It's a lot of that's a it's a hormone like. Can you imagine just walking around without testosterone your man? That's a hormone. I mean like there's a lot of people that are deficient in Vitamin D. It's a steroid hormone. It gets converted into a hormone vitamin. You know it. It's important. It's really important so I went off tangent but anyways what can I ask you this boy? Where office what is what is happening to people when they are vitamin D. Like what's happening in Vitamin D deficient? What is happening in the body? That's causing their immune system this this hormone deficiency not having this vitamin d whether it's through sun exposure. There's lots of things I mean. It plays a key there's vitamin D RECEPTORS. On like your immune cells and the reason for that is because when the hormone vitamin D hormone buying stood receptor it activates all these genes the genes do stuff. That are you know regulate immune function you know. There's there's studies that have shown people and I love these studies because because they basically take away the People's complaints about you know there's lots of epidemiological studies showing that low. Vitamin D is associated with disease XYZ. And everyone's like well you know they're out in this. They're not in the sun as much so they're not as healthy. They're not as physically active. And not whatever even though those confounding factors are usually corrected for its old at the end of the association right. Everyone's like correlations station which is true. But sometimes you gotta look at the full body data. You know There are genetic polymorphism so so there are people that have variations in genes that cause them to genetically have lower vitamin D. And so this this is called Rondonia. Random Ization you can take a person. That's that has genetically like it's genetically low vitamin D. You're categorizing them based on their vitamin D levels. You're categorizing them. Based on their gene and those people are more likely to die from respiratory infections. Just based on that alone. So yeah that gene it's known to lower. It lowers vitamin leads to lower vitamin D levels. And so like those people are more likely to die from respiratory infections than people. That don't have that which it's a great way of randomized people by their genes as opposed to doing a randomized controlled trial. Those have been done as well. There was a study that was over. Twenty five randomized controlled trials. People that were given a vitamin. D Supplement varying doses. Either weekly or daily monthly. Didn't work They're the people with low baseline vitamin D level. So people that were like deficient. They were fifty percent less likely to have a respiratory tract infection if they are taking the vitamin D supplement over fifty percent actually and people that had already normal levels still had a protective effect. There's the ten percent less likely so even people that were already considered normal taking vitamin D supplements helped prevent the respiratory tract infection. You too much vitamin D. Yes you can. You can too much so right..

vitamin D deficiency United States New Orleans Philippines South Asia Indonesia Africa England India Sweden chloroquine Michael respiratory tract New York Kobe UK Scotland
"rhonda patrick" Discussed on The Joe Rogan Experience

The Joe Rogan Experience

13:12 min | 1 year ago

"rhonda patrick" Discussed on The Joe Rogan Experience

"Saying you suck. It's embarrassing you go ahead like sometimes when I get nervous my I will start watering like. I don't think there's odd again. That's probably pretty normal. I mean your systems fired up and is probably trying to clear themselves right. Maybe you know I mean. I'm just speculating. Maybe people will message me after this. This podcast that happens to me you and I'll feel better like I'm sure doesn't sound that odd. That's certainly not embarrassing so I don't know why embarrassed by eyes watering if you're nervous thanks for being here really appreciate it. I am super at always happy to come. Well we've been talking and we've been talking about immune systems and this is one of the main things I wanted to talk to you about. What are these trick is always hearing is shelter in place? Where Mask don't touch anybody? Don't go outside but we're not hearing. What can you do to strengthen your immune system and I think as a public health public service health thing. This is one of the most important things that I think you can really focus and concentrate on an actual thing that you could be proactive about during this weird time. Yeah well definitely I think focusing on on you know lifestyle factors that you can you know possibly modulate your immune system and strengthen it is is important. What's interesting is that the immune system is doing just so much of course the past couple of months. I've been nothing but like reading about the immune system and trying to understand. Of course this new virus ours co two But I've just learned so much You know over the past couple of months and not an immunologist not an infectious disease expert. So you know. While I've had some training in all G I definitely didn't know don't know everything. There is to know but what you know doing some reading about like why are people's immune systems so different like. That's not the big thing like when you take like a young population as you get older. Your immune system does decline. I mean there's lots of changes that occur but like in general like people have different immune systems. And what's interesting is that there's been tons of like genetic studies done on like you know identical twins and they're followed over time and what's found. Is that genetic is not the major regulator of immune function Something in the environment and what this is what surprised me and I know it's not totally going to answer your question. But will we totally get to that? But the main one of the main things besides age that regulates immune system is like previous exposure to viruses like so I thought that was really interesting and in particular one one virus. The SCIATIC MEGA VIRUS SAMBI. Did you know between fifty to eighty percent of the? Us population has at least by the time they're like an adult has it permanently or I think it's a it's a virus so it's a lifelong thing and this is why it basically so it it. It changes your immune system. What are the symptoms of most people? That are healthy. Don't ever know they have it because there's no symptoms. Yeah unless you're immuno-compromised but most people that are healthy. They don't know that they're infected with say it again. What does it decide Omega? It's cmv sounds like something Godzilla fights there. It is so when so intrigue. But here's the interesting thing about this virus. Is that it. So this is one of the major things. Multiple studies have been looking at you know just immune variability and it's like cmv's been identified in multiple studies and the thing that the reason it got me interested. Because I was like eighty almost eighty percent. I could have right totally. Have it and it changes the immune function. It's totally different between young and old so so when you're younger and if you have it It actually enhances immune function so. They've done studies where like they they have given people influenza vaccine and oftentimes these vaccine studies are used to kind of test the immune response and like how. You're how robust your immune responses. Because you're you're given a vaccine and there's all different types of scenes pieces of an antigen or all different types of ways that you can you expose someone to Bacteria or virus but You have a response to it and the response is you know. Involves your adaptive immunity. You make what's called neutralizing. Antibodies that you know. Basically eventually buying the virus neutralize it prevent pregnant from entering the cell so people that have. Cnbc their young have a really robust response to the vaccine. Much better but older people have the complete opposite where it's like you know. Delete -arious and the reason for that scientists think is because basically this virus it's stuck with you lifelong and kind of reactivates every few years and like every time it reactivates it kind of trains. Your T. cells which are part of your immune system to to become focused on that. Cmv and so as you get older your your t cell population becomes more focused on fighting that virus and less so on other viruses that you're exposed to but this is a virus doesn't have any symptoms most healthy people don't have any symptoms with it. I know it's really weird so what. I'm wondering and the reason I'm even like going here at and it has nothing to do with you know taking vitamin C. or zinc and we can talk about that stuff and Vitamin D. But I just thought it so damn interesting because we hear all these stories in the news where you know some people are a symptomatic. Some people are you know. Some people are just really getting hard hit and these people. Let's say they're more age matched right. We know that elderly people are more prone to severe form. But it just made me think what if this you know. Previous previous viral exposure to something like. Cmv is kind of like also kinda shaping people's immune responses in some way. Surely people are going to be looking looking at that but I just thought that was a really interesting thing. Come across you know and then the other sort of on the same on the same along the same lines. As previous previous virus exposure is like something. That really seems to be something. That is a main regulator of how people like how your immune what your immune response is and so. You mean by how many times you've caught the flu. How many times you've whether you respond to it you know. Yeah I mean like you if you get. The flu is not. Is it like a three day kind of thing or is it gonNA knock you out for two weeks kind of thing? That's what I mean right so I mean if you if you get a sample like they're spending these ciro surveys where they basically that just means they. They'll they'll get a sample of plasma and look for different. Antibodies viral antibodies. And they'll find at any given points. A person has antibodies against ten different viruses. Just randomly you know. So you're you're constantly being exposed viruses. You're not always just don't succumb to them right. You're not always getting sick and so You know like another really interesting kind of thing is like you know there's so the SARS Cov virus It's part of a family of of current Iris's called the Beta Corona viruses. So harsh cove won the virus that was responsible for the original outbreak in two thousand and two or something. The mayor's one in the Middle East and then there's two different ones that are responsible for the common cold now. Corona viruses are only responsible between fifteen to thirty percent of common cold cases. So it's not like the common cold is is illness you get but there's lots of different viruses that can cause it. But what's interesting is that. There's been studies showing that these two. Beta by that are responsible for some of the common cold cross-react with So there's one that cross reacts with the SARS cove one which has very very the sequence is very homologous to Sarcoma virus and It's also been shown that the SARS Cov antibodies against the stars Cope. One can neutralize the common cold one. So there's cross immunity happening between these other viruses right and so there's been some studies by the CDC on SARS Cov to where they found basically That people that are infected with SARS co ff to also boost their antibodies against the common cold. One so you know. There's there's certainly I think a good hypothesis to be made that could potentially one or two of these common cold viruses could antibodies. You make against them could also somehow. Maybe maybe you know interact with the SARS virus neutralize it. I mean that's a big open question. That seems possible without. We don't have an answer to that. I think we will like. There's large there's large scale. Ciro surveys being done. I know at least three that I think his name is Dr Michael Bush's at UCSF. He's like he's he's doing like really large surveys where they're they're going to be analyzing. Sierra from people from like you know blood donors and stuff and like following over the course of several years to see you know just basically understand more thou- now what is the speculation if there's any sort of uniform speculation as to why you when you hear about prisons where a lot of these prisoners. I don't know if you've seen the video going around where one prisoner had Sars SARS cove to and covert one thousand nine hundred and spitting into a cup and then passing it around to all these other inmates so they could all get it so that they get released. So these 'cause they're releasing people especially California which is so wacky they're releasing sex offenders and there's been some really high profile releases of these horrible people that should be in jail probably forever. They're releasing them. It's like it it's really disturbing. But what would cause other than something like that? What would cause all these prisoners to not just be positive that makes sense but to all be a symptomatic. Is there any speculation as to why these large groups there was another one? That was a meat packing plant. Where most of the people were awesome dramatic as well. I wasn't I wasn't aware of the meatpacking one being matic but I did read about the one in prison and it was like blowing my mind like what's going on like that's insane. It's kind of like you read these stories. So so this is like there's one thing that it's important to keep in mind when we say hey symptomatic like you know there's a symptomatic in like a person that never actually get symptoms right and then there's a so there was a study done at the CDC a month ago maybe a little more where they measured like They did it. They did this national fair and jail swab test in a nursing home. Seventy something people and Thirteen of them tested a symptomatic like they had no symptoms but they tested positive but then they went back a week. Later and ten of those people had symptoms three racism dramatic. So and less. Like there's another like if you test someone and there is some dramatic at that time testing. That could be pre-symptomatic right in other words like you have to go back a week later and see if they have symptoms because that that's really important so so let's say even sixty percent were dramatically. I don't know if they went back and tested a week later. It was just like a single time. But that's what that's what this is. What got me thinking about this whole thing was you know in in the prisons and jails. I mean they're in close quarters and you got one virus that someone's exposed you and they all get it right so like what? If there's I don't know the percentage there but what if the krona viruses are going around there what if what if you know some some common cold krona viruses gone around and that those antibodies that they've made to neutralize that Beta coronavirus helping with the SARS cove to like love to see that tested to immunize people vaccinate people. When they go to jail. I was trying to figure that out as well because like the tuberculosis but one of the types of vaccines do for TB like Japan and some other countries where they've got a really low Death rate and so there that's test that's a clinical trial. That's now going on where they're trying to test. But I was trying to figure out your explanation because I would imagine it'd be simple for them to do that. You're entering into prison. They vaccinate you just to. I couldn't come to an answer. I was searching for that. The Internet is trying to figure that out but I think that's also a really good. I mean there's a ton of theories right I mean just you could go on and on and on but the whole thing that I just think that I would like to see more research and I'm just hoping that CD and other people are investigating these these other the crossing unity right like if there's if there's antibodies that you're making against another corona virus. Beta coronavirus in the same family as this one no one's had served one in the United States. That one doesn't that that's not as relevant as the common cold. That's that's very common. So you know. If fifteen thirty percent of the common cold is composed of chronic viruses..

Cmv CDC flu Middle East United States SCIATIC Beta Dr Michael Bush Omega Cnbc Ciro tuberculosis UCSF California Iris Sarcoma
"rhonda patrick" Discussed on The Joe Rogan Experience

The Joe Rogan Experience

01:37 min | 1 year ago

"rhonda patrick" Discussed on The Joe Rogan Experience

"Matter what happens you WanNa make sure that your loved ones are protected and that is why legalzoom continues to provide a reliable way for everyone to set up the right estate plan. Without leaving your home it starts with finding the answers to your questions. Do you need a last will and testament or living trust? What about an advanced healthcare directive? And what's a power of attorney? Well thankfully you don't have to figure out everything on your own legalzoom's online resources make it easy to get started. And if you need to speak to an attorney. They're independent attorney network. Is there to guide and advise you? Legalzoom is not a law firm. So you won't have to worry about expensive billable hours adding up. Take an important step for your family. Today go to legalzoom dot com to get started on a last will a living trust and more or find out how you can speak to an attorney for advice on the Right Estate Plan. Legalzoom where life meets. Legal my guest. Today is a treasure. One of the smartest human beings I've ever met She's amazing and it's always a treat to have on the podcast. A really wanted to talk to her. About what people can do in during his pandemic to boost your immune system and man we get some good stuff really valuable valuable information. I love her to death. Please give it up for the great and powerful doctor. Rhonda Patrick Joe Rogan Experience. Podcast we.

"rhonda patrick" Discussed on The Joe Rogan Experience

The Joe Rogan Experience

02:31 min | 1 year ago

"rhonda patrick" Discussed on The Joe Rogan Experience

"The podcast there fucking fantastic and it's you so versatile you can grill on them. You can barbecue. You could bake you. Can you could cook slow. You can grill things fast. I just I love it. And they're having a trigger day. It's an annual day. A holiday dedicated to traeger that encourages our entire nation to grill and celebrate all things traeger and the traeger day sale goes from. May May Fifteenth. Which is tomorrow too. Well you'll get this. Today may fifteenth to May Seventeen twenty percent off all rubs sauces and liners and they have fantastic rubs. The sauces are great man. I I love their rubs. There says sketchy catching on blackened. Rub their just a love. The rubs there so good so delicious again. I can't say enough good things about him. You could buy them online or you could buy traeger. Through ten thousand plus stores nationwide visit traegergrills Dot Com. That's T. R. A. E. G. E. R. Grills traegergrills DOT COM slash. Joe Use the Code Rogan at checkout to get free shipping on all orders were also brought to you by the mother in cash cash APP the easiest way to send money between your friends and family without having to hold paper cash cash Abbas also the best way to try to grow your money with their investing feature an unlike other unreliable bullshit ass investing tools that force you to buy entire shares of stock cash APP. Lets you invest in the market with as little as a dollar a fucking dollar? What's holding you back? When maybe movable bitcoin cash is also the easiest way to buy and sell bitcoin. So what the fuck do you waiting for and when you download? The cash APP entered the referral code. Joe Rogan all one word and you'll receive ten dollars and the cash. Excuse me and the cash APP also send ten dollars to our good friend. Justin brands fight for the forgotten charity. And we're we're honored to be a part of this program and very proud that through this program. We have raised a shitload of money and have built several wells in the process of building. Several more right now and my friend. Justin ran is literally one of the nicest human beings has ever lived. He's.

"rhonda patrick" Discussed on The Kevin Rose Show

The Kevin Rose Show

11:39 min | 1 year ago

"rhonda patrick" Discussed on The Kevin Rose Show

"Everybody kept rose here. Welcome back to another episode of the Kevin Rose Show happy twenty twenty a brand new year and so I'm really excited to have doctor Rhonda Patrick on the show because what better way to address in health and longevity in January. It's surely a topic that is on a lot of our minds. I for one. I'm going to try try. Mostly mostly Pasqua -Tarian Diet for this first month and get my blood work checked and see what it does to some of my numbers I'm also going to be cutting out drinking drinking for the most part because I have a plan to Japan at the end of the month I will be drinking in. Japan will be having Saturday and good Japanese beer but the first few weeks they will not have any any drinks and get by blood tested before all of that anyway. Doctor Rhonda Patrick is one of my favorite scientists. She goes in reads leads. All the published studies around health and longevity and really takes that information out of there that is too technical for the average person to understand and then translates slates it into things that we can incorporate into our everyday lives. This is the best way to get your health advice. People like doctors are always always four five ten years behind except for some Dr Peter but but the average doctor is is many years behind what the science is actually telling us to do. So if you want to know the latest and greatest it's best to go to scientists and thankfully do to podcast. Ron has a fantastic podcast and also a great website called foundmyfitness.com. She has been able to give us that direct link to scientists and so she interviews a bunch of great scientists and really help help us make better decisions earlier on so for example in this episode. We talk about mega threes. Why they're not all created equally and there's various this different forms of Omega Three? We talk about which ones that she takes. How much she actually takes personally? Lots of great information there because not only is she Understanding understanding the science to relate to us but also has published her own science around mega threes. And she's done a bunch of research in regards to make it through his impact on dimension in Alzheimer's so great to half talking about that we also talk about metformin which is very hot drug right now hot. I don't know if he can call a drug hot. But it's a very very popular drug at least in Silicon Valley For people take into extend life and some of the potential pitfalls that it has we also talk about a compound called so for vein gene which is found in Broccoli. She talked about at length on her own podcast about sulfurophane but there is some new data out there that we cover we also talk talk about a new brand of sulfur fame that she has imported that she takes so a lot of interesting stuff. There we cover sauna usage. Some new studies have come out there so a lot of really new things to chat about in this was a great episode. I really enjoyed it and I know that you will too so happy. Twenty twenty cheers to you really hoping that all of us happy and healthy this year Introduced some new healthy habits into your life and Hopefully subscribe to all of Rhonda Duffy as you'll hear her talk about later in the episode when she talks about all the new things that she's building for her website as well so I hope you enjoyed the show this is doctor. Rhonda Patrick Doc Rhonda. Thanks so much for coming back on the show you were actually my very first guest in now. I look back. And I'm almost like forty plus episodes deep so so thank you you for returning a totally. Yeah I totally remember that. For the first episode recorded a few years ago I was living in New York. I didn't have any babies like you didn't have any babies excite change definitely. Things have changed a lot. Becoming a parent is like the the definitely a huge change in the life. Yeah absolutely fluently. I'm just now returning getting enough sleep against the things are things are looking up especially for for Doria's well one of the things I wanted to cover. That has changed since as we last talked as you had really gone deep and published a paper around the phospholipid form of Omega threes than its benefits. I was wondering if you could bring us up to speed on that And what your current thinking is on Omega three supplementation so when it comes to talking about phospholipid. Dha When it comes to DHA General D H as one of the Omega threes? It's predominantly found in marine sources. Really what I care about. Is You know getting it to the brain. That's like my number one interest and the only type of Dha that crosses the the blood brain barrier is Dha that is bound to albumin which is a protein found in your bloodstream? Transports a variety of goodies. In addition to Dha to other tissues including the brain rain but there are two forms of Dha that are bound to albumin and these different forms are transported by different mechanisms so the first is Dha that that is not as terrified. It's not bound to anything other than albumen. So it's in a free fatty acid form and I often refer to that as Dha a free it's free it's not bound to anything. Aside from albumin. It gets transported across the blood brain barrier via this mechanism. That's passive diffusion. and which just means it's you know passably crossing the blood brain barrier and the blood brain barrier. There's a variety of things that you know. Make it up but but one of the things that's important in this discussion. Is that endothelial cells. Line the blood brain barrier and they're the endothelial cells are attached to each other by lied tight junctions so this passive diffusion mechanism. Where'd free? Dha gets across the brain depends on the integrity of the blood brain barrier so so Unfortunately as we age the blood brain barrier becomes compromised and this is even more of an issue and people that have an April four L. E. L. April four is just a gene and A Lil just means one copy of the gene. You have two copies of every gene one from your mom one from Your Dad's we have up to a liles of every gene and just bring people to speed if you have one copy of this gene. Your how much more likely to get Alzheimer's Disease People that have one copy of the April. Four ELEO are about to twofold more likely to get Alzheimer's disease and people that have no copies of it people that have two copies of it. It's not very common so about twenty five percent around. The population has at least one copy of it to copies much much less common. I don't know the percentage off the top of my head but you can figure the math out if you know. Twenty five percent has one copy what you know. Two copies would be but that increases the risk for Alzheimer's disease from anywhere between ten to fifteen fold in. What percentage of the population that is diagnosed? Those with Alzheimer's disease has at least one copy anywhere between sixty five to eighty five percent. Wow Yeah so this is a pretty big indicator then it is and we could spend hours talking about the reasons why that is and I do talk a lot about that in my paper that he published last October in Facet Journal but but basically to get back to the whole. Dha Part of the story. I mentioned that there's two ways it can be transported brain. This one form that's free you know not bound to anything other than albumin. It goes through passive diffusion however April before actually disrupts that because it does compromise the blood brain barrier and that even gets worse with age things like traumatic matic brain injury also compromised barrier. The good news is there is another form of Dha that is bound to albumin. It's a form that is a specific type of fossil so lipid form called Leisa foster title Coleen Dha or Dha Lice OPEC as. I like to call it for short. And that's also transported across the blood brain barrier through an entirely different mechanism uses a transporter called. MFS D to a and basically when this phospholipid form of Dha binds to the transporter the transporter flips it across the outer membrane into the inner membrane of the blood brain barrier potentially bypasses any defects for example apple in tight junctions. NFL's just mentioning. which by the way April before does disrupt tight junctions in lining the blood brain barrier? So I sort of argue in my latest publication that this specific Dha Lice O.. P. C. Form of Dha may be a nice way to bypass that defect that April before it causes or even just normal brain aging causes where you can get Dha into the brain is. Does your hypothesis here. That lack of this. Dha is a cause potential cause of of dementia yet specifically making people with April four more susceptible to it so Dha plays a lot of important roles in the brain. It plays a role in preventing and ameliorating a couple of the hallmarks marks associated with Alzheimer's Disease Tangles and Amyloid Beta plaques and that's been shown in clinical studies it's been shown that Dha supplementation. Can Dan lower the amyloid burden. And also tangle pathology in people have them so specifically people with Alzheimer's disease and it also can improve cognitive function The other thing that. Dha does it's really important for transporting glucose across the blood brain barrier and this is a really really major hallmark of Alzheimer's Disease Not Getting Glucose into the brain. Basically that is actually something that can be observed before any other clinical features of Alzheimer's disease and it's specifically specifically found early people with April four so DHA's important for increasing levels of the transporters that transport glucose across the blood brain barrier the glucose transporters. So I I always thought that you know people for a while. We're calling dementia or Alzheimer's disease like potentially type three diabetes ladies. I'm sure you've heard it called that before I always thought an increase. Too Much Glucose in the body would be a bad thing but here you're saying the brain getting a lack of glucose is the bad thing what I'm saying here. Yeah is that getting not having glucose in the brain can be a bad thing. But that's separate from obviously from like district. Blood Blood Glucose I levels and insulin insensitivity lick. Those things are all hallmarks of aging and cause multiple multiple problems for sure. It's kind of a different thing that I'm talking about here So like brain glucose levels are important for preventing a lot of the the hallmarks associated with Alzheimer's disease. And this has to do with with a lot of like very specific molecular mechanisms having to do with like forming cow tangles and stuff like that so not being able to get glucose into the brain can play a causal roll out hammers disease. And perhaps that is also linked to this type three diabetes that you're referring to that would be you know a completely separate but sort of a parallel mechanism Gotcha. Dha I think it could play a role in addition rice or Dha is important for getting glucose in the brain but also some new research does indicate that you know insulin. Insensitivity can reduce glucose getting into the brain as well so those things could even possibly center. Dr Dr who knows I mean it'd be nice to see data on that but in terms of getting the and the brain and like the question you kind of asked at the beginning. I'm and I'm sure people are wondering is like what what are the dietary sources of these different types of Dha the free Dha versus Lice OPEC Dha the one that's phospholipid form..

Alzheimer's Disease Coleen Dha Doctor Rhonda Patrick Alzheimer Japan Rhonda Patrick Doc Rhonda Rhonda Patrick Rhonda Duffy Kevin Rose New York Dr Peter Ron metformin Dr Dr Doria Facet Journal OPEC apple L. E. L.
"rhonda patrick" Discussed on The Kevin and Ryan Show

The Kevin and Ryan Show

11:39 min | 1 year ago

"rhonda patrick" Discussed on The Kevin and Ryan Show

"Everybody kept rose here. Welcome back to another episode of the Kevin Rose Show happy twenty twenty a brand new year and so I'm really excited to have doctor Rhonda Patrick on the show because what better way to address in health and longevity in January. It's surely a topic that is on a lot of our minds. I for one. I'm going to try try. Mostly mostly Pasqua -Tarian Diet for this first month and get my blood work checked and see what it does to some of my numbers I'm also going to be cutting out drinking drinking for the most part because I have a plan to Japan at the end of the month I will be drinking in. Japan will be having Saturday and good Japanese beer but the first few weeks they will not have any any drinks and get by blood tested before all of that anyway. Doctor Rhonda Patrick is one of my favorite scientists. She goes in reads leads. All the published studies around health and longevity and really takes that information out of there that is too technical for the average person to understand and then translates slates it into things that we can incorporate into our everyday lives. This is the best way to get your health advice. People like doctors are always always four five ten years behind except for some Dr Peter but but the average doctor is is many years behind what the science is actually telling us to do. So if you want to know the latest and greatest it's best to go to scientists and thankfully do to podcast. Ron has a fantastic podcast and also a great website called foundmyfitness.com. She has been able to give us that direct link to scientists and so she interviews a bunch of great scientists and really help help us make better decisions earlier on so for example in this episode. We talk about mega threes. Why they're not all created equally and there's various this different forms of Omega Three? We talk about which ones that she takes. How much she actually takes personally? A lot of information there because not only is she Understanding understanding the science to relate to us but also has published her own science around mega threes. And she's done a bunch of research in regards to make it through his impact on dimension in Alzheimer's so great to half talking about that we also talk about metformin which is very hot drug right now hot. I don't know if he can call a drug hot. But it's a very a popular drug at least in Silicon Valley For people take into extend life and some of the potential pitfalls that it has we also talk about a compound called so for vein gene which is found in Broccoli. She talked about at length on her own podcast about sulfurophane but there is some new data out there that we cover we also talk talk about a new brand of sulfur fame that she has imported that she takes so a lot of interesting stuff. There we cover sauna usage. Some new studies have come out there so a lot of really new things to chat about in this was a great episode. I really enjoyed it and I know that you will too so happy. Twenty twenty cheers to you elam really hoping that all of us happy and healthy this year Introduced some new healthy habits into your life and Hopefully subscribe to all of Rhonda Duffy as you'll hear her talk about later in the episode when she talks about all the new things that she's building for her website as well so I hope you enjoyed the show this is Doctor Rhonda Patrick Doc Rhonda. Thanks so much for coming back on the show you were actually my very first guest in now. I look back. And I'm almost like forty plus episodes deep so so thank you you for returning a totally. Yeah I totally remember that. For the first episode recorded a few years ago I was living in New York. I didn't have any babies like you didn't have any babies excite change definitely. Things have changed a lot. Becoming a parent is like the the definitely a huge change in the life. Yeah absolutely fluently. I'm just now returning getting enough sleep against the things are things are looking up especially for for Doria's well one of the things I wanted to cover. That has changed since as we last talked as you had really gone deep and published a paper around the phospholipid form of Omega threes and its benefits. I was wondering if you could bring us up to speed on that And what your current thinking is on Omega three supplementation so when it comes to talking about phospholipid. Dha When it comes to DHA General D H as one of the Omega threes? It's predominantly found in marine sources. Really what I care about. Is You know getting it to the brain. That's like my number one interest and the only type of Dha that crosses the the blood brain barrier is Dha that is bound to albumin which is a protein found in your bloodstream? Transports a variety of goodies. In addition to Dha to other tissues including the brain rain but there are two forms of Dha that are bound to albumin and these different forms are transported by different mechanisms so the first is Dha that that is not as terrified. It's not bound to anything other than albumen. So it's in a free fatty acid form and I often refer to that as Dha a free it's free it's not bound to anything. Aside from albumin. It gets transported across the blood brain barrier via this mechanism. That's passive diffusion. and which just means it's you know passably crossing the blood brain barrier and the blood brain barrier. There's a variety of things that you know. Make it up but but one of the things that's important in this discussion. Is that endothelial cells. Line the blood brain barrier and they're the endothelial cells are attached to each other by lied tight junctions so this passive diffusion mechanism. Where'd free? Dha gets across the brain depends on the integrity of the blood brain barrier so so Unfortunately as we age the blood brain barrier becomes compromised and this is even more of an issue and people that have an April four L. E. L. April four is just a gene and A Lil just means one copy of the gene. You have two copies of every gene one from your mom one from Your Dad's we have up to a liles of every gene and just bring people to speed if you have one copy of this gene. Your how much more likely to get Alzheimer's Disease People that have one copy of the April. Four ELEO are about to twofold more likely to get Alzheimer's disease and people that have no copies of it people that have two copies of it. It's not very common so about twenty five percent around. The population has at least one copy of it to copies much much less common. I don't know the percentage off the top of my head but you can figure the math out if you know. Twenty five percent has one copy what you know. Two copies would be but that increases the risk for Alzheimer's disease from anywhere between ten to fifteen fold in. What percentage of the population that is diagnosed? Those with Alzheimer's disease has at least one copy anywhere between sixty five to eighty five percent. Wow Yeah so this is a pretty big indicator then it is and we could spend hours talking about the reasons why that is and I do talk a lot about that in my paper that he published last October in Facet Journal but but basically to get back to the whole. Dha Part of the story. I mentioned that there's two ways it can be transported brain. This one form that's free you know not bound to anything other than albumin. It goes through passive diffusion however April before actually disrupts that because it does compromise the blood brain barrier and that even gets worse with age things like traumatic matic brain injury also compromised barrier. The good news is there is another form of Dha that is bound to albumin. It's a form that is a specific type of fossil so lipid form called Leisa fos title Coleen Dha or Dha Lice OPEC. As I like to call it for short and that's also transported across the blood brain barrier through an entirely different mechanism uses a transporter Called MFS D to a and basically when this phospholipid form of Dha binds to the transporter the transporter flips it across the outer membrane into the inner membrane of the blood brain barrier potentially bypasses any defects for example apple in tight junctions. NFL's just mentioning. which by the way April before does disrupt tight junctions in lining the blood brain barrier? So I sort of argue in my latest publication that this specific Dha Lice O.. P. C. Form of Dha may be a nice way to bypass that defect that April before it causes or even just normal brain aging causes where you can get Dha into the brain is. Does your hypothesis here. That lack of this. Dha is a cause potential cause of of dementia yet specifically making people with April four more susceptible to it so Dha plays a lot of important roles in the brain. It plays a role in preventing and ameliorating a couple of the hallmarks marks associated with Alzheimer's Disease Tangles and Amyloid Beta plaques and that's been shown in clinical studies it's been shown that Dha supplementation. Can Dan lower the amyloid burden. And also tangle pathology in people that have them so specifically people with Alzheimer's disease and it also can improve cognitive function The other thing that Dha does it's really important for transporting glucose across the blood brain barrier and. This is a really really major hallmark of Alzheimer's disease. Not Getting Glucose into the brain. Basically that is actually something that can be observed before any other clinical features of Alzheimer's disease and it's specifically specifically found early people with April four so DHA's important for increasing levels of the transporters that transport glucose across the blood brain barrier the glucose transporters. So I always thought that you know people for a while. We're calling dementia or Alzheimer's disease like potentially type three diabetes ladies. I'm sure you've heard it called that before I always thought an increase. Too Much Glucose in the body would be a bad thing but here you're saying the brain getting a lack of glucose is the bad thing what I'm saying here. Yeah is that getting not having glucose in the brain can be a bad thing. But that's separate from obviously from like district. Blood Blood Glucose I levels and insulin insensitivity lick. Those things are all hallmarks of aging and cause multiple multiple problems for sure. It's kind of a different thing that I'm talking about here So like brain glucose levels are important for preventing a lot of the the hallmarks associated with Alzheimer's disease. And this has to do with with a lot of like very specific molecular mechanisms having to do with like forming cow tangles and stuff like that so not being able to get glucose into the brain can play a causal roll out hammers disease. And perhaps that is also linked to this type three diabetes that you're referring to that would be you know a completely separate but sort of a parallel mechanism Gotcha. Dha I think it could play a role in addition rice or Dha is important for getting glucose in the brain but also some new research does indicate that you know insulin. Insensitivity can reduce glucose getting into the brain as well so those things could even possibly center. Dr Dr who knows I mean it'd be nice to see data on that but in terms of getting the Dha and the brain and like the question you kind of asked at the beginning. I'm and I'm sure people are wondering like what what are the dietary sources of these different types of Dha the free Dha versus Lice OPEC Dha the one that's phospholipid form..

Alzheimer's Disease Coleen Dha Doctor Rhonda Patrick Alzheimer Japan Doctor Rhonda Patrick Doc Rhon Rhonda Patrick Kevin Rose New York Rhonda Duffy Dr Peter Ron metformin Dr Dr Doria Facet Journal elam NFL apple
NAD+, Nicotinamide Riboside, and Nicotinamide Mononucleotide with Rhonda Patrick

FoundMyFitness

06:58 min | 1 year ago

NAD+, Nicotinamide Riboside, and Nicotinamide Mononucleotide with Rhonda Patrick

"I'm going to talk about a molecule that has become in recent eight years extremely relevant to the field of aging specifically. I'm referring to any D. plus which I will refer to. As N de for short and some of the related precursor molecules kills Nicotinamide riboside often referred to as an R. and nicotinamide mononucleosis tired often referred to as an these two precursor sir molecules are called an boosters which can both be found as consumer available supplements. Just in case. You've never heard of any. It's probably one of the most important molecules accuweather on the planet so important in fact that without it life would cease to exist to NATO boosters nicotinamide said nicotinamide mono nuclear tied at very high doses. This is an animal. Studies have both been shown to improve the way multiple tissues and cell types age including skeletal and heart muscle brain and stem cells. There have also I've been to preliminary clinical trials in humans showing nicotinamide riboside may raise energy levels in white blood cells. which is pretty darn cool however I still? I think there are many open questions that need to be answered regarding. Ad Boosters and I will touch on some of these concerns in this episode but the possibility that intracellular NASD may be increased from a supplement or several types of supplements is awfully interesting if not downright exciting for one. Simple reason energy levels decrease with age and a decrease in energy eighty levels across a variety of types of tissues is associated with many and naming many hallmarks of aging these hallmarks of aging that are associated with age related plated changes in the pool either directly or indirectly include things. Like loss of Proto. Stasis Might conroe Dysfunction Glucose Intolerance Insulin Insulin Resistance Cellular senescence altered epigenetics and more this is partly because the availability of promotes. DNA repair capacity while its decline is associated associated with the accumulation of DNA damaging reactive oxygen species another reason is because Nada's required for energy production so when energy levels decline as they do with age this results in less energy production in many tissues like the brain immune cells muscle etc.. That means those organs do not work as well as they once insted. During youth. When energy levels were maintained? Any ideas also required for the activation of a very important family of enzymes involved in longevity called Sir Tunes and the complete answer to why energy levels fall with age is still an open question. But there's a few things we do know. As we age chronic inflammation and immune activation two processes that consume NASD tend to go up and with them our need for DNA repair placing an immense demand on our energy pool. Meanwhile while our ability to produce and recycle tends to fall with age we're GONNA cover a lot of ground in this episode but I wanNA start with an overview of any D- Any any deal has a very important role in energy metabolism and can be synthesized in the body from a variety of dietary sources including the amino acid trip to fan which which is in tons of healthy foods like salmon spinach and nuts and the three forms of niacin which is vitamin B.. Three also found in foods like lean meats legumes veggies edges these three forms of vitamin B.. Three include nicotinamide also called Niacin nicotinic acid and nicotinamide riboside they are commonly referred to as Nice in equivalents but dietary sources of energy are not the major source of any D. The major source of energy is through a recycling mechanism that we will discuss later. The reason for that is because our organs require such large quantities of that it would be impossible to consume enough from our diet. So why why do we require such large quantities of any first and foremost energy plays a critical role in energy metabolism critical. Meaning without it. You can't make energy entity participates in back and forth processes of reduction and oxidation often referred to as Reebok's reactions these alternating conversions of NFC's oxidized form which Canady to its reduced form. An Age are crucial for the metabolism of glucose and fatty acids and the formation of ATP. Since both the oxidized is in reduced forms of amd are essential for these linked sets of reactions cells need to maintain massive concentrations of both and a D. and an age basically without these molecules. Not only would we cease to exist but life on our planet would cease to exist and it is also a cofactor for many different important enzymes in this context a cofactor means something that is required for an enzyme to work at has to bind to the enzyme and this activates the enzyme so it can performance function so. Let's talk about a few of these enzymes. Several these NATO required enzymes are inside the Mitochondria and this is another way and participates in the generation of energy aside from itself being a type of energetic currency it also acts as a cofactor for enzymes involved in the production of energy from glucose outside of the minor Qendra this is referred or to as glycolysis many types of cells us look like Hollis's as their primary source of energy. For example. Red Blood cells do not have any medical Andrea so one hundred percent of the energy. They require to perform their function of delivering oxygen and other goodies to other tissues in the body comes from glycolysis and plays a very important role in mitigating DNA. A damage you need repair damage to DNA. That is because any cofactor for one of the most important enzymes involved. In repairing DNA damage called part one the activation of part one requires an enormous amount of any D for example excessive DNA damage in subsequent one activation have been shown to decrease energy levels to twenty to thirty percent of its normal levels. The ability to repair DNA damage is important for longevity. LYMPHOBLASTIC cell lines established from blood samples of humans who were centenarians. One hundred years or older have significantly higher part one activity than cell lines established from younger individuals. That are seventy years old part. One activity has also been correlated with maximum lifespan. In mammals the higher the part one activity the longer lifespan. For example the activity of part one one was measured across multiple Mammalian species and the difference in powerpoint activity between the longest lived mammals tested which were humans and the shortest lived mammals tested. which were rats? It's was fivefold so not too much of a surprise but genomic stability which relies on energy in general and pop ones specifically maybe very important morton longevity is required to activate signaling proteins knowns or two which are highly conserved enzymes play roles in health span and longevity in multiple organisms uh-huh so to ends are linked to the regulation of variety of metabolic processes like the response to stress and the modulation of lifespan. The way they do this is through EPA genetic regulation so twins utilize ad to remove specific chemical structures called seal groups.

Nicotinamide Dna Damage Nasd Glucose Intolerance Mononucleosis Accuweather Reebok Sir Tunes Niacin Nato EPA Nada AMD Hollis Andrea
New Study Shows Health Benefits of Daily Saunas

The KFBK Morning News

01:14 min | 1 year ago

New Study Shows Health Benefits of Daily Saunas

"There's a new study out that in shows that taking a sauna has comparible health benefits of short moderate workout this study was conducted by researchers at martin luther university holly whittenberg that's m. l. u. it's located in germany doctor rhonda patrick you're about to hear from her in this next audio clip has a p._h._d. in biomedical sciences from the university of tennessee she also has a website is devoted to wellness issue she talks a lot about taking a sauna and the benefits of taking a sauna she recently appeared on the joe rogan show to discuss the overall benefits of taking asana including this study see this new study and an older study as well this older study is from about one year ago when those who regularly took us on experienced a forty percent decrease in mortality according to that study they following these men for twenty years they were in there between fifty to sixty five when the study started and those men that had been using this on a more frequently had a forty percent reduction in dying from many causes that aren't accidental okay i want to talk about the new study in just a second but this study that's a year old says that the decrease in mortality was dramatic in these people who took took him release four to five times a day they took a

Martin Luther University Rhonda Patrick M. L. U. It Germany University Of Tennessee Joe Rogan Forty Percent Twenty Years One Year