22 Burst results for "Remm"
Dr. Christopher Earley: The Science of Sleep (Or Lack Thereof)
"Chris. Can you just help us. Define the phases of sleep. What are those. the sleep. studies are grams that we'd have more or less broken sleep up into two big bits. Which is what's called non remm sleep and ren sleeping ram stands for rapid eye movement and bow. Quarter of your sleep is involved in this remm state. Which is the dreaming state. The non remm state can be partitioned into what's called stage. one stays two three and four with stage. Three in four really caught. Slow wave sleep stays one would be drowziness. We spend most of our time in stage. Two slate the deeper sleep so called stage. Three four tends to be a large portion of receive when you're younger and so when you're in your teens and twenties that's about twenty percent nubia sleep if you're in the fifties and sixties that's about three or four percents Did you say that the really quality sleep goes down to like three percent. When you're old well the deeper sleep our ability to maintain sleep in general from h. Point of view is a little complex but essentially the elements of sleep when we talk about states. Three four sleep that is much higher than the younger and gets less and less as we get older if i already gets down to a few percents as i mentioned after age of fifty so for the lay public. What's the significance of those stages. And what should they be targeting. And what do we do on a day to day. Basis that is either helpful or harmful to the stages that we actually require the biggest elements of sleepiest consolidation of sleep. Whether you're in stage two stage third stage four. It's how consolidate your slate is. What does it. What does that mean consolidated so humans unlike cats and dogs really need a continuous period of slate. Now we might be able to break that up into two sections four hour and a four hour sex but generally most people need between seventy eight hours of sleep and it needs to be fairly consistent from start to finish if you're awakening frequently at night that sleep fragmentation so the first and foremost thing is trying to get a consolidated amount of safe. That is from the time. Your head hits the pillow to the time you wake up in the morning that period of time should be seventy eight hours and basically you should be able to have slept through that full duration of the night. The second issue is that if the different stages of sleep are relevant to you experiencing a certain good quality safe as much as it may be involved in membrane and memory consolidation so the deeper sleep is in stage. Three four might be relevant to how you clothe onto certain memory. Generally you're spending most. Your time is stage. Two three or four. That's good if spending too much time what's caught stage one sleep. That's bad because states one sleep would be drowsy. You're sort of in sleep but alice eight. You're never really not quite into sleep yet. And so if you have a disproportionate amount of stage one sleep. Then you're more likely to experience a sense of not fully rested tired memory problems things like that
COVID-19: ‘little or no’ benefit from remdesivir: WHO
"Results from a UN coordinated international trial looking at four cave nineteen therapeutics have shown little or no positive impact on preventing death in patients infected with new corona virus, the Solidarity Therapeutics Trial, overseen by the world. Health Organization who found that REMM disappear hydroxy chloroquine, Lapenne Aveer. Rootin- and Interferon. appeared to have little or no effect on twenty eight day mortality or the hospital course of covid nineteen among hospitalized patients. The study involved more than thirty countries and investigated the effects of the treatments on mortality ventilation and length of stay in hospital. It did not examine other uses of the drugs such as preventive treatment, which would. Require further trials in a related announcement. The WHO said that Covid nineteen had also highlighted the increased vulnerability of people with high blood pressure to the coronavirus. The warning is based on data for more than one hundred twenty countries showing significant caveat related disruption to treatment for people suffering from chronic health conditions with findings showing these patients make up fifty to sixty percent of all deaths through covid. Dr Bent Mickelson director of WHO's Department of noncommunicable diseases said that more than one point one, billion people around the world suffer from hypertension mainly in low and middle income countries when it comes to call it nine, thousand, nine, hundred, hypertension, one, hundred and twenty two countries that has reported. US that in over fifty percent of the country's the healthcare services disrupted fully or partially fifty percent of the country's, and in addition we see a high number of is we don't have global figures yet, but we see in the rain show fifty, sixty percent of the people that are severely ill and died in hospitals from code have hypertension diabetes, and so forth and the working on the global targets.
Treatments from Gilead and Regeneron Move Forward in Battle Against COVID-19!
"Some glad to be back and have a good show for everybody. We're GONNA talk about a few interesting companies. That had some good readouts this past little while as well as ones that are upcoming. So we're going to start by talking about axiom. Therapeutics and their readout in Alzheimer's Disease Agitation. Or then GonNa move on and talk about Gilead add in all the updates. We saw their Endesa of your trials. Never GonNa talk about another company. That has some. Kobe related. Work going on which is regeneration. And I usually don't talk about mid large-cap biotech but regenerate is is an interesting one. Especially because I've touched on their main compound lia in previous videos so I thought I'd do kind of a deeper look into them and we're GonNa talk about that in big detail so with that. Let's just get ready to it. And the first topic I want to mention is acts on therapeutics so their company that saw a huge runup in twenty nineteen with the development of their drug. Axs Zero Five. Which is a combination of Dextrathoraphan and Wellbutrin and they've already seen positive readouts in major depressive disorder with this compound as well as a couple of other ones and they saw mixed results with treatment resistant depression. But I think they're going to move forward with some trials any way to confirm that data but what they also wanted to to look ad. And this is the data that in presenting here is the effect of access zero five in Alzheimer's Disease Agitation so one of the symptoms associated with Alzheimer's disease is this agitate that comes along with it and it occurs in around seventy percent of all patients so that works out to six million people in the USA. So it's a pretty huge indication in one that I didn't really look at in serious capacity before I took a position because it was originally planned for that treatment resistant depression but I think the stock had a lot of potential. Besides that so. We saw a readout this week. That showed a significant improvement in this. Cma I total score in patients treated with excess zero five compared to both be appropriate riches or placebo and view pro free on its own. Didn't have a substantial effect on Alzheimer's Disease Agitation. It was only when it was mixed with desperate dextrathoraphan in excess zero five that it saw this improvement so this is very beneficial for the song. I think it opened on that day you know upwards of one hundred and change and then it fell back down. I think it closed this week at ninety but very positive for the company and they need to discuss with the FDA how they're going to move forward and whether or not this is GonNa be considered a pivotal trial for them so we might see some insights in their Q. One earnings call which is taking place on. May eighth but is definitely impressive for the company and this molecule is going to be a huge revenue driver for them once they get those filings through and get approval. So that's excellent therapeutics and I'm still holding onto the thirty shares that I bought so let's talk about Gilead and their drugs death severe. That's been investigated right now for the treatment of Cova Nineteen and the importance around rim of your has less to do with Gillian specifically and more to do with how it's going to be implemented in the hospital system and prevent them from being overburdened as states kinda revamp up their economies again because if from desktop here has an effect in it lowers the time in which patients need to be in the hospital. The chances of the hospital system being overburden reduces substantially since we can you know get these patients in and get them out quicker. So that's why remm desperately is so important and we saw originally that Gilead published a study with regards to the compassionate use only remedy severe and that was only a single arm study. That didn't have really great conclusions to be drawn from but since then we've seen results from four studies and I'm GonNa talk about these in some detail because we heard that Dr Bounty announced that there were significant results in that they're going to move forward and approve rendez severe for Cova Nineteen and we also heard on Friday that trump is going to announce the approved use of reinvest fear for this so the four studies that we got results for our this China study that was published in the Lancet and this was an underpowered study so they weren't able to find patients who enroll in this study so they just took the data can the study published in The Lancet. The next one is this. Niaid study that was also a randomized placebo controlled trial and then there were two phase threes. That Julia did call the simple studies. And this is to compare the ten day treatment versus the five day treatment and the reason why they did this I believe is because they don't really have the commercial capacity to produce unlimited rendez severe. So if they can show that the treatment of as severe works just as well with a five day treatment they can save more doses for more patients. Let's first talk about the China study which was published in the Lancet a little while ago and this was a randomized placebo controlled trial in Severe Cova nineteen patients and just to note that this was underpowered. Despite the fact that they did statistics on it there weren't enough patients to really get the power that they were looking for from the outset. And what we see here is that patients treated with Rendez. Aveer were more likely to die if you look at this. Kaplan Meier curve and the hazard ratio was one point two three. Which means that. If you were treated with reservoir you had kind of a twenty. Three percent increased risk of dying the other attract that. I'm showing here is the viral load. So one thing that I was hopeful to see is that Rendez released had an effect on viral loads and the one thing to note though. Is that these samples were taken only from the news. Affairs in the oral faring. So that's kind of your nose area and your throat but not your lungs. So there's a chance that there would have been a significant difference if swabs were taken or if they did some kind of leverage to get samples from the lung and see whether or not rendell spearheaded effect on viral loads. In in that capacity the study also looked at length of hospital. Stay in that was also not significant in this study although the safety was actually okay. So that's one positive outcome from all this but given that this study was underpowered. We need to take these results with a grain of salt. But it's not super encouraging. That REMM has no profound effect in these patients specifically but they also went ahead and did this. Niaid study so we look at bat study. They looked at one thousand sixty three patients and these were hospitalized. Kobe nineteen patients so still in the severe range. And here's what the press release said preliminary results indicate that patients who received rendez severe. Had A thirty one percent faster time to recovery than those who received Placebo and the P value here is less than point zero zero one specifically the median time to recovery was eleven days for patients treated with severe compared with fifteen days for those who received. Placebo results also suggested a survival benefit with a mortality rate of eighty percent for the group receiving Rendez severe versus eleven point six percent for the Placebo Group and the P value here was point zero five nine so this is the study that I think Dr Found. She was referring to saying that there was a significant benefit to rendez severe treatment. And I definitely see a benefit if this is the difference in the time to recovery. The survival didn't have a significant effect. But even if there isn't a significant survival benefit if there is a benefit to the time to recovery. I still think that is profound and we'll be able to help the burdening of the hospital system. Which is what I was referring to earlier in talk so we still haven't seen a lot of details in this. Study some stuff that I'd love to see. Our viral loads led to look at the safety to see more details in in the effects. Endesa there had so. We don't really know exactly what's going on. But this is the study that I think the. Us government is looking at to say whether or not it is a drug with an effect that will be rolled out in the country and it looks like that's going to happen even before we are going to see the details of that study but it is what it is and then the last studies. I wanted to talk about. Are these simple studies from Gilead and this is an open label trial that looked at a five day treatment or attend day treatment and the results are that the study demonstrated that patients receiving a ten day treatment course of Amdex aveer achieved similar improvement in clinical status compared with those taking five treatment course and the odds ratio here is point seven five with a ninety five percent confidence interval of point. Five one to one point one two on day fourteen so this is good news. It shows that they only need to treat rim desperate for five days and it's GonNa be not significantly different than they treated with ten days and we've been seeing a lot about Gilead having around a million doses of rendez severe before the end of the year so given that only five day treatment is needed. They're going to be able to save rim desperate for more patients. And that's a good thing because like I said I don't think Gilead expected at the beginning of the year have to roll out the commercialization of severe. But they're gonNA have to do that. Some capacity and in this way can be able to save some doses for a lot more people and I I put a little note here about the safety so breathe three or higher liver enzyme. Lt Elevations occurred in seven point. Three percent of patients with three percent of patients discontinuing rimmed as severe treatment due to elevated liver tests. So this is kind of a negative thing that is going to affect a decent number of patients because I think a lot of the comber abilities of Cova nineteen patients are issues related to their liver
Dr. James Taylor on Chronic Pain and How CBD Inspired a Transformation in The Waiting Room
"Today I'm really excited because I'm joined by doctor. James Taylor from North Carolina in some of my home stomping grounds in the southeast James. Thanks so much for being willing to take the time and speak with me today or Jason. It's modern thank you. Yeah totally okay so just to prime our listeners a bit. Do you mind speaking a little bit about the work that you do. And how it connects to to Hampton CD and all that so are merely a pain physician we have seven pink clinics in North Carolina it was the opioid crisis. Prices that got me involved. Oh in the CBD space About two years ago as premiers coming from medical boards and hospital administrators straighter on We've got to change the way we manage pain CBD came up and opportune time for our medical practice to look figure out what is what do or what is it not do. Offer patients in pain It was very taboo back then in North Carolina to Even even think about this bring it into our a practice So initially when we did that we had a symposium and we brought a lot of people to the symposium we brought the police sheriffs departments attorneys board and members You know anybody we could think of that. Might want to object and so we gave him the opportunity to object if we were going to bring. CD into the State of North Carolina and start using it with the patients No one objected They all agreed were in the middle of an opioid crisis. And we gotta pull out every tool we possibly can use in order to positively affect that So our journey only began their our. We studied some patients and felt good about continuing to recommend this to our patients. And we've just continued to try to understand this this even better of of what it's doing for these folks and how we can positively impact. Their lives in that journey has been a very up and down journey journey. A- and so being new into the cannabis space You just don't realize all the variables that you're going to have to deal with but it seems like we take two steps forward one step back. Three three steps forward four steps back in so that kind of roller coaster. I'm understanding what folks in the canvas world have been up against so the last number of years. Yeah and I've got to say I'm a little surprised that there wasn't much resistance in those early conversations. But that's that's great to hear as well just that there's A desire to try to bring in any safe tools that can be brought in to try to alleviate some of those opioid problems that we're that we're dealing with now and what it What forms of? CBD are being administered in North Carolina. Because I have to admit I'm not super familiar with what's Osman going on there. Recently are people using Like tinctures or edibles different. What types of products are they engaging will primarily tincture In our medical practice we stuck with tincture. We wanted to keep it simple. Yeah you know. Our patients aren't the the most educated and we typically serve the poor and the elderly orderly So we didn't want to bring a large variety of different things so the tincture. We kept it simple. But in the state of North Carolina of of him stores are opening up all over the place that have Food products the smokable him The tinctures bay products The whole Gamut You know the North Carolina and FDA. They have come out a pretty strongly to say. Hey we don't want this food products right but they still sell them. And nobody's out a monitoring regulating them in. Uh we'll see where all that end. Yeah it's it was interesting to me to see Saw Picture very recently of a store in Tennessee that was a CD slash him dispensary and it was set up very similarly to all the cannabis dispensaries. You see you out here on the West Coast or in states that have legalized. But it's all hemp products. That's fascinating to me. That that's spreading across the country and giving people access to canvas products even if it's in that limited CD sense that they wouldn't have access to otherwise. Have there been to your knowledge. Any issues regarding Product safety contaminations or MHM product consistency in that realm. Oil is for the public standpoint. I don't think the public of of see's much of that. I think there's a couple of news articles where some product came in how they came from out West that probably contained. THC mother was not a hemp to rob product worked but there has not been a lot of media attention on Tainted are bad product of now we have a laboratory and we do testing So half my patients take a product that we kind of oversee from growth to extraction the other half of my patients take products they get online So that's very good for me. I'm able to see what these other products are In the new all take sometimes these products from the patient and test them and see what's in them in so we're discovering quite a bit Eh. What's on the label is not necessarily what's in the bottle? Yeah you know tattle on anybody But I think it's a bigger problem than we all realize. Yeah I completely agree just for my own analytical work that I've seen there's Quite a lot of inconsistency batch to batch When manufacturers are making products and then sometimes the differences in product compared to label sometimes that's genuine just product manufacturing variability and sometimes it's militias sometimes? It's just outright companies lying in order to get product somewhere where they it can be sold. Can you speak a little bit to how you know. So you specialize in pain in trying to to help people deal with particularly Egli chronic pain How do patients seem to be reacting and under what kind of dosages yet great question so when we initially brought it into our practice We took one hundred patients in. We studied them at that point. We didn't know that there were different. CANNABINOID profiles we didn't didn't know how to dose it We just did not know a lot. We just put this bottle of CBD in front of a hundred patients And said take a half a dropper twice a day and that should last in thirty days and now come back and tell us what happens and we follow them over about a three month period of time so with not even much knowledge we Able to gain so much insight. Now's a pain physician. We were looking for a pain reduction and of them. Not Needing their opioids And what we found on our initial survey is there. Pain did not affect their pain whatsoever. but what we found or was number one. They slept so much better interesting. He came back other sleep. Went from about four four and a half hours to six hours a night and they started reporting that they were dreaming though so we set. Gosh this is good. You're sleeping better. You're dreaming you're getting more restful sleep deep someone who's got a chronic medical condition. This is very valuable to give you that a rejuvenation of that you need in order to face the next day With your continued chronic condition. The second thing they came to us and told us is that they're anxiety level was less that they were less anxious in. They found that when they were having an anxiety flare instead of reaching for alcohol or Benzodiazepine which we know those plus narcotic will equals death? They were reaching the battle hymn the very quickly they realized if they took other tincture within twenty thirty minutes their prices was starting to dissipate. And so we saw this as risk reduction. Yeah Yeah Yeah exactly. So we can protect our patients out. This is a wonderful reason to continue to pursue those. Yeah and that actually echoes a lot of what I've heard from other physicians and nurses. That have talked to that. Sometimes the therapeutic response you get from canvas product isn't necessarily a direct reduction of the symptoms that you're necessarily targeting but Hits other symptoms that accompany that problem that over time are likely to have a positive effect on the core issue that you're trying to treat as well is it's interesting to hear about People people starting to dream again so that indicates that REMM cycles must be being established for anybody. That's sort of unaware have chronic pain. Wake you up constantly throughout the night and so it's hard for your body. Hit actually sink into the. You know that that depressed and to these rim cycles where you'd really Be Having having you know more lucid dreaming and that sort of more intense dreams And so that super fascinating and there's a lot of debate out there right now about how. CBD Canvas Broadly Affect Sleep is there are mixed voices about that and especially when THC's involves so it's interesting to hear from your perspective and a place that is not dealing with thc that you're seeing positive outcomes with sleep 'cause in areas where they are working with thc it's not what has straightforward. Is that because T- can actually interrupt rim cycles and end. It depends person a person of course to we also so saw that initial observational study. The patients came back instead. They were hopeful and for it. I is perplexed us You know we did. It's a literature. Search found that yes. D- Aachen affects. Serotonin Osso we thought. This was a mild anti depressant effect But over the course of of these last years we realized it's more than that it's neurogenesis it's neuro plasticity. These patients brains. Were starting to grow into win. Your brain starts to develop new luke pathways you all of a sudden have hope you don't patients who are in pain. Chronic pain I think have a form of PTSD you know and they just can't. There's just stock. They don't know life is going to be like this the rest of their life. It's never going to get better kinda stuck in this. RUT IN CD allowed them to have hope in that hope of translated into a lot of positive things in our clinic before our waiting room was it was awful as miserable place to be ENSO's very depressing But all of a sudden replaying reggae music people are talking to each other and sharing. Their experiences really changed our atmosphere of our clinics.
"remm" Discussed on The School of Greatness with Lewis Howes
"To sell things put michael jackson on a commercial for thirty seconds and everyone that doesn't work anymore so fine what works for you and make sure you have a point of view. It's amazing. This questions called three truths. Okay so imagine it's your last day on earth <hes> many years from now and you've accomplished everything you want. You've created created every restaurant concept fitness written the books. Whatever you wanna do you've created and you've got no regrets yup. Whatever reason you've gotta take it all with you so all the restaurants to go with you. Wherever you pass and you get to leave behind three things you know to be true about all of your experiences in life that you would share with the world kind of like your three lessons to humanity and that's all people would have to remember you by. Would you say your three lessons or three truths. Wow this is two people. Pause on this because this is a whatever's off the top of your mind right now doesn't have to be i would want to leave. This world all to know is that we lessons. Three lessons have real relationships. Many many likes. Many friends doesn't equal many real friends. One partner in one best friend is bigger than any of that. Well just one just one one love in one best friend. If you can die with that you are you are way better than most people on this wall yeah okay. That's that's one to to what you love and you'll never work daniel life whereas i love doing. You'll never work life. What if your work. If you work is fun. It's not work yup number three. Take care of your body or no. This is possible man. It's true health everything. A a healthy man has ten thousand problems sick man has one..
"remm" Discussed on The School of Greatness with Lewis Howes
"Phone for the first hour that i'm awake. I do my twenty minute meditation tation a drink my one liter of water. I work out six days a week. I'm unapologetic for that hour and a half so i will not regret <unk> starting another business in order to not have to do those things so i think i'm i'm trying to accomplish those things by. I will regret if i do. You're not continue to grow if i do not continue to listen to people if i start to believe my own b. s. again yeah if i revert back to the six year old or twenty twenty six or thirty one or thirty five year old version of myself that that stopped listening to others that started to believe my own the as if i revert back to that guy i will be. I'm really disappointed and i will be very regretful that i could not have learned from these opportunities that i had that would be the biggest regret if i go if i go backwards instead of forwards to that guy or any other version of myself from the past. I would be really disappointed yourself well that would that would be that. Would it'd be a real a real disappointment. I'm inspired man. I didn't know what i learned from you but i'm really inspired to go to catch more guy gets you into rumble rumble mile away not even and how can people support you. I've got i got three questions for you finally but how come people support you with your endeavors right now. I continue support where we have you know we have. We have catched. Roma were opening catch stake in september new york city. It's a fifteen thousand square foot four hundred fifty restaurant steakhouse house at the i think steakhouses needs to be redone and i think there's a twenty twenty version of it and we're excited to give it a try to try to hit that so that's a that's a big one in a new one for us. We're opening our second that can concept for rumble which is our treading concept which is half treadmills have a weight and rumble. Boxing is half the class boxing and the other half wait so we're just boxing. We taught you something. We didn't think you didn't think you know how to do it. We got to do it and in treading. We're gonna we're gonna make you enjoy something that you don't like doing which is running right. No it's not fun to run experience lo-look ashington the music and the lights party like a soul cycle feeling look. I think so cycle was the king of finish. There's certainly the they're the geez of this game day are what inspired me you to get into the group fitness and i think they've done cycling. We are really we were very excited to do boxing and we're very exciting to do with now trading so that opens at the end of october in that opens in twenty third street down the block from romo boxing and also in san francisco simultaneously in the marina here to l._a. To it is maybe we're work. Trust trust me. There's space the team. The one thing i can guarantee that the team that we have working hard to get it wherever wherever it makes sense to have so for me those those are things that are great honestly i if anything here is valuable in some way can help you use it and then if anything more importantly you use it and it works works share it yeah. That's that on instagram twitter what you spend time on personally online. I'm on instagram. My name's eugene rim <hes>. I think i have a twitter better. I think it just connects to my instagram but yet i'm on instagram eugene raymond website to you personally or no no oka <hes> no instagram message tag you all those things instagram's are mad and <hes> you know i i take breaks from instagram now on a regular basis. Take probably a you know a week a month off but i think if people there's a lot of entrepreneurs that listen i think if people wanna learn about branding and culture go follow catch instagram and rumble because you guys an amazing job of creating like this experience people and i think they can learn a lot in their businesses. We have a small business. You're a solo entrepreneur..
"remm" Discussed on The School of Greatness with Lewis Howes
"Seeing kevin durant de'andre andre door delivers. What do you mean covers people and people in the room. I'm sorry the restaurant at seven hundred seven hundred fifty people in l._a. Or l._a. I was here last night. We're in los angeles so those six gentleman had a great experience right but if we just focus on them the other seven hundred plus. That's a miss so i think the best way to get all of this to work is make sure that everyone is hand on narrow people with way more relationships than i do way more people in their cell phone than i ever have and there are many many businesses that start with celebrity that are complete and total failure big time in fact. I think if you did a case study daddy on it. I think it would be probably nine to nine to one ten to one of successful business started with celebrities versus those for everyone is that what because for everyone randy gore gerber and george clooney who absolutely loved their product and create qasim he goes. There's nine hundred and ninety nine who are inauthentic to the brand. I wanna make money or maybe they are authentic to the brand but don't have the the business practices involved or don't have the timing or donors partners so they maybe they don't have the capital title. Maybe they don't have the team and maybe they don't have the timing so for every time someone refers casa migos which i really just enjoy the billion dollar business amazing randy gerber over who i who used to work for his love tequila since the day i met him when i was twenty four years off he he knows this business and they both enjoy their product. Mike hillman as well so that's why everything had to work. They had their authentic. They're back financially. They probably ran a great business and they also oh had all those relationships. It's never one thing so someone's listening to this looking for a silver bullet for success. It doesn't exist because if there was one everyone would just mimic and as soon as they mimic it it will change the yeah you no longer unique so how important relations been few over the last fifteen years since since he started ten june and have been in the business. Have you cultivated these relationships consistently for fifteen years. Have you burned a lot of relationships from certain the things i think a relationship guy i work really hard on relationship. I try to put relationship before dollars in almost everything i do which is why i love love having partners so to me and this isn't the case in my business but if i did ninety percent of the work and you deten and we were co partners i wouldn't care hair-splitting at fifty fifty with you because the result is i want to say to me that ten percent that you do might be really special and allow how is to create this one percent product so i don't really have an issue that so my relationships are priority to me. I care about friendships. I care about relationships. I hope i haven't burned a new relationship. I'm sure everyone has burned a relationship. I would never want to and sometimes though you have to look at someone in the say what you're asking for is unreasonable. Yeah i would love to make you happy but it doesn't work for me and if that's a burning of a relationship then that's a burning of relationship..
"remm" Discussed on The School of Greatness with Lewis Howes
"Got square braun even probably more investors and how do you wanna track. Those investors and these are people with big egos a lot of big successes who are saying you know what i deserve. Thirty percents whatever it is how do you divvy it up all the investment and still make it worth it for you with four partners tons of investors. Everyone thinks that they're responsible for the amount of clients is getting or the success the promotion how do you manage all the ego and energy of that all you manage. Everyone else's ego by controlling your own so you start by saying that this doesn't doesn't happen because of me and then you and then for me personally. Eugene ram says i can't do this by myself without this team without this team. I'm i'm a team guy. I'm i do not like doing businesses by myself. I love my partnership with mark until man i love my partnership with the rumble founders i love my investment community unity from from equinoxes and harvey steve atkins scooter and blake and all the other celebrities so to manage everyone else's eagle. You must not have one and for me. That's super important to me. I remember tommy hilfiger. <unk> said data speech he said i'd rather be a small piece of an elephant and a large piece of a and i'm interested in doing big things but i certainly know that i do not have the skill set to do all aspects of this business so that's the first thing you need. The second thing you need to do is treat. Everyone equally so everyone involved is an equal participant and everyone's money is the same and everyone's everyone's ruins believe as the same so no matter how much they put in everyone's treated the same and no one's responsible to say. I love rumble. Here's ten bucks now. Say it again and and say it again so that's the other thing with our social media. We have never done a paid pay to play in our entire life. I have never paid a human being to walk into catch and say have dinner and posts about it. We have never paid a single human being to walk into rumble and say i'll give you five thousand dollars for this post. Never but what we accomplished meals or classes reserved yeah. We'll do what we would do that do that to you. I would do that because that's that helps and adds value to everyone else's experience so that's part of the business model but as far as a pay to play thing we don't do that so i think it's really important that everyone is treated the same and then for me. It's it's not one thing like oh. I know a lot of people a lot of people know a lot of people so you have to know a lot of people you have to have a great track record or at least a track record where you've been honest throughout the whole way where people wanna do business to you you so great product an honest track record and then you really just gotta make sure that they love it because if they love it. They're down to do it much more and then you have to make a decision here. She wants to do it for the right reasons down to have them but if someone's trying to get more or less think they're more important. No one is more important than the whole yeah rumble. Boxing is the brand that is the important product. A team in the people who work rumble boxing are the most important thing catch eugene remark burma silman fatigue not is not the priority for catch. It is the brand that is the food is the services vibe and if last night it's it's kevin durant and the andre jordan they're they're important but no one individual makes it. We did seven hundred eighty five covers last night on a wednesday. Everyone enjoyed seeing.
"remm" Discussed on The School of Greatness with Lewis Howes
"They're from because we had so many yeah so having that those principles so that was super challenging and i remember sitting with five friends my best friends from college and we'd we'd take a ski trip every year and we were sitting poconos. No no more action now now. The go-to speeches we go west actually don't know what he's skiing here. It is easy. It's it's not good. <hes> i only started just giving us thirty two but i remember we were sitting there and we all said what would you like to change in this upcoming year just in a conversation and everyone answered and he came to me you and i said i think i'm doing everything right. I think i got it all handled while i think i'm i'm working on my business. I'm working on my health. If i'm working on my spirituality i'm working on my relationship on just great and i came home from that trip and i think literally there was a light switch of just just that's when every challenge started coming wow so i think it's almost comical that what your ego will allow you to believe steve i the reality that sets in and i think ever since then i'm just more much more cautious and much more checks and balances. I had no checks and balances owns is to feel that way. It was just a feeling and that's a challenge between gutten data right like i'm a big. I'm a big guy but you better have like that's that's like <hes> if you run a five minute mile but i can run a ten minute mile but i got g._p._s. of where we're going to but you're running in a circle so you may be more more of an athlete than me but without that g._p._s. You don't know where we're going to reach that mile point so i think data as i've gotten into my late thirties and now in my forties using data to support my gut is the best balance of both in any one in any extreme is a terrible way hey to do business me. It will work once in a while but if you wanna keep if you want a good batting average right doesn't work yeah. It doesn't work as true man. You got another data of live okay..
"remm" Discussed on The School of Greatness with Lewis Howes
"Because we're in the business a fund. That's a challenging thing about the business of fun. It can be really fun but you better find the structure to it and if you're all structure you're boring. You're boring and then you're a widget company and then people won't come to your restaurants gyms or anything like that. So we went through this process of fourteen. The world told the way we did it was wrong and it snapped us back down but that was the best thing that ever happened to us because it allowed us an opportunity to retreat reset refocus probably get some coaching and mentors because again going from one to fourteen. Who's gonna tell tell you you're wrong. When everything you do is right as working is working so and that's important because if you came to me renounce it. I'd like to open up restaurant. I said i'm gonna say you're gonna fail. You didn't even tell me the idea and i'm going to say ninety five percent right just because you say you want open up a restaurant. It's going to fail so you really. We wanna make sure in the beginning you listen to that five percent really yeah. I get that most are gonna fail but that's not this. This is going to be different and you need that to be successful in the beginning but after a while you have to start understanding that i should probably start listening to a few more people because we know how the story ends yeah just like every athlete that makes one hundred fifty million dollars in burns it all. How's that possible their whole life since they've been five years old. They're the best at what they do. They're the best kid in their middle. Schools are the best kid in their high school. They're the best in their college. Why would they everything it's going to nj talents never going to run out -solutely why would they think of it ever gonna end and you can understand dandy now and even i can understand now. You get caught up and that's when you slap back. That's when you reset and with that reset. We found on this diamond. The diamond is catch and it wasn't four a._m. Nightclubs seven days a week it wasn't multi concepts mexican food and this wasn't multi see city it was catch and you're in new york city and that property was reshaped and it was led by great food great service great revive in that was put into place and our basic core principles of running the business take care of the staff staff will take care of the guests guess we'll take care of the bills in the past it was i need money so i'm gonna take care of you the guests and staff you better work because you're making money too so so i had it backwards and i take full responsibility for that in the past. I was the other thing. I blamed other. People blamed employees that worked for us. I blamed developers developers and partners and other other people but quite honestly i i made the decision to hire all those people so as soon as you take accountability and responsibility for your failures and other people may not have executed but you hire them. <hes> you decide to put him in that position. You chose not to pivot earlier. You chose to go down the path. You didn't instruct and inspect you cut them on for a year or two years hoping they change and hope it's not a strategy yeah and that that's a big one is not a strategy. I hope this works. That's not a strategy uh-huh that is almost just blind faith and occasionally bind faith works but i think if you're trying to be successful in a percentage game you need need more than blind faith fourteen to focus on catch expand to los angeles understand clubs nightclubs. Stop then then yeah you said we're done with a nightclub wasn't one moment where twelve places close but you know ten june in its eighth year. Stop being successful. We we gave it back to the our partners. Onus decay upstairs eben arthur's had run. Its course the club below. It has run. Its course atlantic city which was a two point four four billion dollar casino where we were doing incredibly well. The casino went bankrupt.
"remm" Discussed on The School of Greatness with Lewis Howes
"I must say it's right or wrong. I think about it often and i think about what life was like when we had when mark and i had one nightclub and we lived in a cool apartment three blocks from the club and i think it's i think it's growth and i think it's evolving and i think it's opportunity to grow other people because at the end of the day if you're not in service to others you'll be incredibly lonely true. That's <hes>. I really feel that what if you're given a platform to create things that more people can enjoy that can employ more people that can then make them enjoy things and do more things like that's exciting to me so at twenty five or thirty one club would have been enough but that's not enough if you want to grow. It's really important to know what your limit is. Am emma you know. I i've gone through several times where i think my limit is. This i push it and then the world slaps me back. So how did that happen. I mean look we had led from one venue june. Which was the hottest nightclub in two thousand york and the country it was it was certainly certainly something special and it was something we certainly weren't expecting every celebrity all the models all the important people right day. One was kanye west jay z penelope. That'd be crews are first birthday party. Mark and i are both born on the tenth of june so we call the ten june really wanted to make sure everybody knew <hes> <hes> involved at all you know of course not but and i think it's okay at twenty eight twenty nine. You wanna make a name for yourself and there's no that's why i say that when people say like oh what's the key success i was like i have what has been successful to me what has failed to me and i'll share that and i think everyone has their own different version. I think there are times to be you too. Have you go into positive about who you are and then there's times to pull it back. There's no one strategy. I think at twenty eight twenty nine to make it about out yourself because it was about us and we were driving it so that went to one and fast forward to fourteen fourteen nightclubs and restaurants in restaurants restaurants atlantic city miami new york new jersey all of it and we had go back down to three one to fourteen said fourteen. We slap in the face we we. We thought it would be great to just continue to do it. The way we did it and grow it and that's where you have to learn about structure and strategy rations rations and stuff where it's it's not just the sizzle and you need the substance so now in two thousand nineteen its structure and culture and wearing a seesaw in our business on how to balance the a culture which is the fun because we're in the business a fund. That's a challenging thing about the business of fun. It can be really fun but you better find the structure to it and if you're all structure you're boring..
"remm" Discussed on Heartland Newsfeed Radio Network
"We roll around Remm cycle, and they give you a sleep score. Basically, they have Gema fide sleep. But new research shows people are so anxious about getting a good sleep score that it keeps them up at night. Know goes, you don't get a good sleep score. You won't get into a good sleep school. Parents have to Photoshop your face onto a sleeping person. You don't you know, people people like I don't know why. But to cheat their step counter they'd sometimes attack their dog we, we I learnt that from you, Peter, what would be, what would be the sleep tracker equivalent like attaching it to a corpse. No, it would be the stepsister a dog in the sleep is her cat. Doesn't sleep tracker customize it. Or does it tell you what you're supposed to do? It just gives you the raw data you're asking, I think, what it does because my phone does this without me. Asking it, it says, you haven't been getting enough sleep, sort, of lectures, you. Get more sleep your phone. Does this. Yeah. Do you turn your phone off when you sleep? Well, I've got lead this thing tells me time for bed, and then you go to bed. Yeah. So.
"remm" Discussed on NewsRadio KFBK
"Investment could be in jeopardy. Drywall cracks water intrusion and doors that are difficult to open or close are critical signs that your home's foundation may need repair, these problems won't go away. They'll only get worse if you're concerned about how to get started on your foundation repair. There's an easy way to pick a reliable trustworthy company that knows what they're doing and won't rip you off nor Cal. Remm Jack has created a free consumer guide. Seven things every homeowner should know before hiring a foundation repair company. It's free at foundation repair report dot com foundation repair report dot com, nor Cal Ramjet realizes that repairing your home's foundation is a big deal. That's why we've. Committed ourselves to overcoming every problem you may face with any foundation repair company. Don't wait foundation problems can turn into foundation failure. Get your free consumer report out foundation repair report dot com or Google, nor Cal Remm Jack Remm Jack repairing foundations since nineteen sixty eight. Every year millions of Americans use opiates to manage pain. Pain can be unrelenting overwhelming and all consuming. So why so many of us try to manage pain, only from the palm of our hands doctor, prescribed, opioids or appropriate in some cases, but they just mask the pain and reliance on opioids has led to the worst drug crisis in American history? That's why the CDC recommends safer alternatives like physical therapy to manage pain. Physical therapists treat pain through movement hands on care, and patient education, no warning labels required. And by increasing physical activity. You can also reduce your risk of other chronic diseases pain is personal but treating pain takes teamwork. When it comes to your house, you have a choice, choose more movement and better health. Choose physical therapy. Visit move forward P T dot com to find a physical therapist in your area. This message is brought to you by the American physical Therapy Association news ninety three point one, hey. F. B K..
"remm" Discussed on The Peter Attia Drive
"In other words. Remm sleep is the new kid on the block in the time course of Evelyn Remm sleep fuss, the image later in the course of evolution. And Secondly, what's kind of wonderful is it emerged twice independently once in buds and once in mammals, so you could argue that well if deep nonren- sleep, which is much more educationally from an evolutionary perspective it's much old foam of sleep. Wouldn't it be much more necessary fundamental one and therefore wouldn't you die sooner? No salerooms. Seems the opposite because you'd say well for the same reason that the cockroach can survive the nuclear disaster, the avian mammalian pathways more, evolved, neuronal presumably, and therefore probably requires something essential in rim that when it deprives you it takes away your superpower, which is cortex. And I think that's exactly what it is. Which is when you look at anything that has essentially complex enough system. Maybe that's what the pressure for this thing called Remm sleep emerged, even though we know that non Rhames leap actually supports many, essential central nervous system functions like sign up, pruning, and some great sort of neural thinking the Glymph attic system, clearing up that sort of similar to your oxygen analogy. Which is when you go from being an anaerobic to faculty van aerob- to a robe who's going to be most sensitive to oxygen the nation. Exactly. And so it's always a dangerous scientific hypothesis where you can figure both ways. But I always. Found that interesting and it's commented, but I just wanted to note that full, you know, twenty minutes ago in kind of in defensive Remm sleep that, you know, if we should it will be worried about the amount of deep sleep that we're getting absolutely. But we also need to be worried about how much Rhames sleep at getting because from a pure mortality risk standpoint. Remm.
"remm" Discussed on Impact Theory with Tom Bilyeu
"Deep sleep Remm sleep from what we know in a lot of this is very new science, right? A lot more about memory consolidation. Right. That that's actually when your brain is playing things, you know, at three x speed to help you remember them by repetition. How we know it's happening at three X. So that's by looking at just FM, our eyes and various other EEG type equipment. There's even some new work being done and one of the things that they're showing is if you can actually implant a thought during the early phases of sleep, actually, you can almost potentially trick your brain to work on it during REM sleep on tell me more. What do you mean? How do you implant the idea there? This is very very experimental. So I think the idea is, hey, can you actually bring a thought either through a visualization through an audience or you go to bed you're saying there was immediate minutes while you're falling asleep. Yeah. Sort of like inception. It's starting to get pretty nuts out there. Okay. So. Finish up because this is so interesting. So what have they done in the studies like what necessarily owns on? Is it someone saying something to this is super experimental like nothing yet? They just had a conference all about this like, basically, helping people dream and have certain thoughts during REM sleep that can help them solve problems in their lives. So some really cool work. But yeah. I wish I wish I knew more. But it's literally happening as we speak. But getting back to sort of why these things are happening, and what you know. So deep sleep your physical body being restored. Right Ramsey thinking about your mind and.
"remm" Discussed on FoundMyFitness
"Signature in your EEG. That is predictive if you'll notice go lending is stage two and sleep spindles both of which seemed to have this bizarre sort of you know, coincidental spike right around this developmental phase of crawling standing walking so many things going on during the development. I'm I mean, it's just it's so fascinating there for sure language too. I mean when we've looked at this as well with teaching adults foreign languages, or even actually just mathematical languages or oughta fischel, grandma sleep is a huge component in that. But they also saw this fascinating thing with development, which was about not just concrete lending of individual facts. But the generalization of knowledge, so this is sort of the thing that I think separates us from computers. At least for now, which is that computers. Very good storing individual bytes of information in a way, very clearly, and we can do that to storing individual facts, but what computers don't do which is what we do is intelligently integrates an associate them together. So that we can extract overarching patterns and schemers and statistical rules about this thing called the world in which we live. And yes, I was just going to say that you can with infants you can teach them just these novel sounds, but an each one of these strings of sounds is unique and different. But there's something common about the grammar. That is binding an overarching across all of them. There is an overarching schema that you could learn in addition to each one of the individual facts after they've had a nap versus an infant that has not had a nap post nap, the infants have extracted and undestood the generalized rules of what they've been lending, not just the individual facts, whereas infants that have learned, but haven't napped have not sort of made the abstraction so mind being a nap Nathi, I've I should be rewarded for that. Right. Absolutely. And it stays from infancy all the way through to adulthood, if you napping, I'm not gonna well. There's a few double edged sword aspects of now. So I wanted to ask you a question you're talking about basically being able to connect the dots. You know, how how that's different differentiates us from what what a computer can do. I mean, one of the things. But is there a certain I remember reading in your book? And this is probably the part of the book that I was more skimming, you know, like now is the the the importance of Remm sleep and dreaming and creativity is that connecting because I feel like connecting the dots is some some, you know, require some creative thought to be able to kind of like put things together and come up with the big picture idea picking out. So is it known as Remm sleep important for that? Yeah. It does seem to be. So if there is so I mean, we could take a step back and think about how to sleep achieve memory processing..
"remm" Discussed on Speaking of Psychology
"Obviously, they don't have sit down exam dreams n even in our culture people who decide to be wanna be actors or musicians from an early age, though, have a variation. That's the dish in dream. They're not sitting down to take an exam, but they're showing up with their musical instrument. And they realized they studied the wrong piece of music or they can't find the addition hall. So so there's some variation even in those the standard ones. But, but there's something to the idea that there's some universal very frequent dreams, meaning something similar for most people who have them. In those feelings behind those streams could be like you said, maybe some some sorts of shame or some sorts of anxiety about what's what's going to happen to be tested in some way that sort of thing. So they're common feelings that underlie them well and yet different different shades for for different ones. But just in line with sort of what they otherwise our common metaphor, you know, if you quote feel exposed or feel naked that usually more of a shame social, disapproval if you're being tested, you know, that's more than a thority figure is evaluating. You sort of argue measuring up, you know, to society in general or authority, so in so the most of the recurring themes dreams are exiled dreams. But whether whether it's about sort of being competent versus being socially appropriate. Those those tend to be represented by difference. Sutphin things. And I've heard that that some people say that dreams don't mean anything at all that they're just random impulses from your brain when you're sleeping or perhaps just consolidating memories that sort of thing, and there's no deeper emotional meaning behind them. But, you know, many people do believe dreams are important that they help problem solve perhaps find inspiration, which I'll ask enough in a few minutes. But what is the psychological research? Save out the importance of dreams, and do we know what would happen if we didn't dream? Well. Let me answer the first the first part, I it's a little simpler there there is some research. There's a limit to how much you can deprive people of rim sleep. And it does have to be depriving Remm sleep. Not quite all dreams happen in rim sleep in one of the things that you see if you deprive people of ram sleep is that you begin to get more reports that sound like full-fledged dream narratives out of other stages of sleep a few of those happen anyway. But it's like there's some pressure to dream that..
"remm" Discussed on WMAL 630AM
"Care for yourself, which ultimately to be a good caregiver. You do need to take care of yourself. You've got to exercise eat, right and take your Jared tall, right? But seriously, caregiving is important. But to be a good caregiver you've got to take care of you. Gotta take care of you. If you only taking care of other people a time, you will burn out. In fact, that's why there's such a turnover in the caregiving business. There's a lot of turnover and families in caregiving. Sleep cycles, a wonderful application. You can download it on your phone. It's free to get the premium version costs you thirty bucks a year. What it does is? It actually listens to you. While you're sleeping. It helps you evaluate at the end of the night when the best time is to wake up, and it wakes you up then seriously. So I've used it for about a month now, and it will actually grade the quality of my sleep. It will tell me if I was snoring when I started how long I snored. It will also tell me that it woke me up towards the tail end of my sleep in a half hour window because I we naturally all of us naturally. Go in a rhythm of a cycle of sleep. I didn't understand this. So let me explain when you go to sleep. You're just not like asleep in this constant state of non movement in sleep you go deep into Remm sleep. You come back out, you drop interim sleepy come back out, you drop, a, sleep, etc. Sometimes you go two or three or four times sometimes twice. Sometimes once it all depends. Right. So. If you can wake up when you're coming out of it and maybe close to being completely awake. It's easier to wake up great idea sleep.
"remm" Discussed on REAL 92.3
"Me To be this weekend As the Now now you've got Was Sports Still won't be misfortune Remm stopping you Hey jake Guess Be. Praised, yeah you forget Because Between Hey Doc Komo I do Would you Two two The girls. Boys neighborhood crazy meter is, here All. Right, let's bring Heather into. The neighborhood Heather Hello Hello.
Study of sleeping fur seals provides insight into the function of REM sleep
"Sleep secrets from first heels i'm bob hershon in this is science update ma'am or rapid eye movement sleep comes right after our deepest sleep periods our brains warm and we experience vivid dreams many scientists believe rim helps us learn or regulates mood but by studying the unusual sleep patterns of first heels ucla researcher jerome segal and his colleagues have found a simpler explanation they argue in the journal current biology that remm activity heats our brains so we're less groggy gets the brain fully functional in preparation for waking first heels have sleep cycles just like us when they're on land but while living it c they sleep with just half their brains at a time to stay alert and keep from drowning and they then stop having rem sleep why seagull says that since they're never fully unconscious first seals at sea don't need the kick start that remm otherwise provides i'm bob hershon for triple as the science society.
"remm" Discussed on WCTC
"Hello remm heating in north brunswick is your heating specialist it's never too late to be proactive in having your furnace looked at with colder weather your furnace will be coming on or cycling more frequently it's better to have it checked now don't wait for an emergency save now and don't pay later remm heating has an impeccable record in helping thousands of homeowners and business owners they carry an a plus rating in service timeliness expert craftsmanship and dependability you come first you save money you get a job done once right we and love they'll back up everything visit they work aarporgcaregiving on don't overpay remm heating to learn is more your alternative to the those public companies service that announcement promise the so brought called to you by seventy aarp nine dollars fix and the ad council if it's too your good to be home true for it rutgers probably sports is there's go don't port be suckered full circle into offers jersey designed 1450 just to get in your door wctc we promise new you brunswick a great price a for beasley a great media job group period station check remm heating in north brunswick remmheating every street here dot is com ap horrific that's scene remm with playing two out m's at a high remm school heating in south remmheating florida dot com remmheating turn on your television dot com right now you're into snow see scenes ice and of more children snow is shorter wreak havoc running anarchy give for this winter their lives can you smarter and take nj what looks transit to be the download night teats the free nj transit app rail the customers school can purchase shooting in ten this trip country tickets and view we have bus not and light rail schedules even and receive hit more march specific travel alerts and advisories that'll make i'm coming your winter to the fore could you'd to talk better about alerts something to else be customized but let me to just the day's note times once again in cities for my colleagues of your commute download the app today visit nj transit dot com or kmm dot org to get started on your smarter winter commute heart disease is the nation's number one killer and stroke is number five let the good news is eighty percent of cardiovascular diseases may be preventable debbie where he is american heart month and the american heart association.
"remm" Discussed on Juicy Scoop with Heather McDonald
"He never pay later remm heating to stuff and yeah overpaid it well here's some ironic staff okay his nephew one of the three ts i believe still goes to my school yeah and at the last halloween carnival they had a carousel that they rent that they rent that is the former carousel from never land really yeah they could move it around lebanon they also had a michael jackson impersonator you've got the the 'neverland for anti carousel a michael jackson impersonator and wanted the end tito son michaels nephew that actually dad at the school but whoa whoa doing what was what was a michael secular personally doing farming something you do whether it's a three day cairn it in the that was going to be affect the nephew who i don't think they thought about it when they're podium or the horror the and then also that same neverland ranch carousel evelyn ridge is of onrunning it's are gone well the rides in the animals are gone yes remember that one monkey lawyer went to go visit greenville any through a shed at apple why windy starve yourself a good line she's likely to ever be brought extra cameras smoking falk off renewable i do it big fat baby that smoke did was to ask the now he's 35 with lung cancer and i don't know smoking i actually did you see a thing on him catch of where where he is now that he's not like eleven but heels nobody knows he's done cigarettes.