35 Burst results for "Remdesivir"

Understanding the Virus with Dr. Howard Fullman

Medicine, We're Still Practicing

05:16 min | 5 months ago

Understanding the Virus with Dr. Howard Fullman

"So i are host the quadruple board. Certified doctor of internal medicine. Pulmonary disease critical care in neuro critical. Care my very good friend. Dr steven day back. How are you steve doing. Okay deceive. oh we have one of our favorite experts returning to us today Howard j fomin. He is board certified in internal medicine and gastroenterology and howard served a multi decade tenure at kaiser permanent day as partner ford member president of the executive committee chief of staff and chair of the quality committee. He has supervised over forty three hundred staff and over five hundred doctors. Howard is now seen your operating advisor at atlantic street capital for their medically focused investments. Dr howard foreman nice to have you back thanks to be here high stated it good to see hey steve. What's it like in the icu. With the kobe patients has it gone. It's been very rough at my hospital. The surges hit us really hard. We actually we had a mini surge. Back in may when everybody else seemed to be really struggling at this time it has hit us really hard we have about one hundred and fifty plus cove patients in our hospital and i bought twenty percent of those are in the intensive care unit and those that intensive care unit. They are all on high flow oxygen or intimated. So they're all very very sick. And howard what. Are you hear about kaiser. How are they holding up in all this. I just very proud of everybody. Credible courage by the patients and their families what they're going through doctors nurses respiratory therapist all staff level of dedication i think of the healthcare professionals are just miraculous people. Tired in was there the other day doing data the procedures. And just in what. I do which is way less difficult than being in the icu. For twelve hour shifts just wearing in the ninety five masks in a shield and all the p p being more cautious than ever and trying to make sure that the patients can get in and out so that they're not in the medical center. One minute more than is necessary. Cetera et cetera. Just makes the practice of medicine which is already something that's very challenging even more challenging but my heart goes out to the patients and that that's just a culprit patients Anyone who needs services. The hospital is having more difficult time than usual inside easy being a patient thunder normal circumstances that along under these circumstances. i'm sure they're all kinds of treatments. That have changed since our last conversation. I mean the remdesivir steroids in a number of other treatments that you guys have raised a bad situation. What's working the best these days. Dr steve in actually the one medication that really has shown to decrease mortality everything that we have is decadent on an age old medication. A steroid that's used to decrease swelling decrease inflammation in the body thus far as the only medication that we're using that actually has been proven to diminish with a twenty eight day mortality. We do give them de severe because there has been shown that there's been some benefit in terms of shortening the course of the disease and so it's still part of our protocol and so everybody who's coming in is getting a coverage for we call community acquired pneumonia in case they have bacteria on top of covid. So they're getting the usual medications for that which is usually as for miocene in something called stuff triax zone but the standard therapy provided you have good kidney function that you're not to overwhelmingly sick is the decca drawn remdesivir but it is the decca drawn. That by far has been shown to be very effective. I do believe for those people who are not terribly ill that are just starting to show signs and symptoms of covid that have various co morbidity is considerably overweight have diabetes a monoclonal antibody that has given an infusion. I believe has also been a game changer. Although i've not seen formal data in that way but those are the big three medications that we give. I mean you've got to look at what's going on here in the us and it's gotta frustrate both of you. Knowing how many people are breaking the advice may be needle one column rules because somehow those of us in the us don't like those things called rules. Frankly i've seen a bunch of parties. Go on in my town. There have been a bunch of weekend weddings and dancing. And what have you and it's almost like. What are you supposed to do as a healthcare organization to get the message across. I can't imagine. What would happen. To dr steve here if there was a surge on top of this surge. That's an important point in all of us in healthcare professions of. I wanna start again by saying lots. Lots of people doing their level. Best imply vincent. I feel really badly for people who don't have a luxury to be at home. That essential workers people who were living in very congested areas. Tranquil did very best. They can difficult circumstances. So that's important to make sure we now. The hard work difficult circumstances lots of people living under now everybody's violating these guidelines but there are people who are either inadvertently or something some cases intentionally violence

Pulmonary Disease Dr Steven Howard J Fomin Kaiser Permanent Chair Of The Quality Committee Atlantic Street Capital Dr Howard Foreman ICU Howard Steve Dr Steve Kaiser Ford Pneumonia Diabetes United States Vincent
Remdesivir combo reduces COVID-19 recovery time

Doctor Health Radio Show

00:20 sec | 6 months ago

Remdesivir combo reduces COVID-19 recovery time

"Reporting A two drug treatment is helpful for covert 19 patients who need extra oxygen, adding Vienna Inflammatory drug Barris seated EB The antiviral medicine. Rimm despair help these patients recover eight days sooner than those that were given Renda Zvehr alone. The study involved more than 1000 people with the Corona virus. That's

Barris Rimm Vienna Renda Zvehr
What Science Has Learned About the Coronavirus One Year On

Science Talk

04:58 min | 6 months ago

What Science Has Learned About the Coronavirus One Year On

"It's a really important moment to look back at our very different reality just twelve months ago. In december twenty nineteen the first infections were just emerging inside of china sars. Covy two didn't have a name yet and no one could imagine the global effects that the virus would have on us all but it was also clear that this novel coronavirus lit a fire underneath the seat of science so my question is how far has our scientific understanding about the biology and the behavior of the virus. Come since then yeah. We have learned some really critical things. About how the virus works and also importantly about how our immune system responds to it and how. This virus sars cope chew. Essentially causes our immune system to misfire in cases of severe covid nineteen and miss misfiring really centers on the very early immune responses that. Our body mounts. These are called innate immune responses this innate immunity is a part of our body that really uses sensors that detect pieces of pathogens. Like the co two virus that are not from our own body in once. These factors are sensors detect these viral bits. They sound out an immediate alarm system. That operates through molecules called cytokines and interferons. These are important for activating those later. Immune responses like t cells and antibodies. That we hear about and what we think is that. It's likely that people who sound this innate immune alarm early upon exposure to the virus and induced early in high levels of that interferon alarm system. Go onto pretty rapidly and effectively clear the virus so these might be the individuals with a symptomatic or moderate or mild disease however what scientists have learned. Is that people who go on to develop severe covid. Do so. Probably because in them. The virus causes a misfiring of that. Immune response so like the wrong sets of immune cells may be brought in and they might not deuce that early interferon alarm system. Quick clear strongly in they can't control the viral load. The virus amplifies to really high levels in their body so their body responds to this continued presence of the virus basically by increasing production of factors. That are involved in inflammation. This is an over exuberant inflammation or inflammatory response. And that's what leads to the lung tissue damage which is really a hallmark of code pathology. So what we've discovered. Scientists over the past year is that there are biomarkers. That can give clues about who ultimately goes on to get severe disease. Scientists have also discovered genetic. Differences are mutations that some people have in those innate immune genes that can contribute to poor initial control of the virus. I think that this understanding that there are essentially two phases of covid nineteen disease that initial phase that's dominated by viral amplification in a second phase that in severe cases is dominated by a misfiring of the immune response is really important is important because it ill. At they're two types of therapies. That are probably needed. Depending on the phase of the disease so drugs that charge it the virus directly to stop its replication is would be things like remdesivir that we've heard a lot about in the news or maybe treating with things like recombinant interferon. This is Something that's used to treat other chronic viral infections. Those types of therapies are probably only going to be effective at stopping nets first phase of the disease but are not going to be very effective If they're given during that second phase because it's then it's not the virus but the immune system that's driving illness so conversely drugs that damp a net over exuberant inflammatory response and decks. Methadone is one of those. These might be dangerous. If given during that first phase when you really want a rapid and robust immune response but could be helpful at dampening the damage that's caused by the immune system at later stages one of the key parts of understanding the virus itself. How find it is scientifically really about timing right. Exactly timing is really key to figure out how your body responds very early and later and you know the timing and dose of the virus that you might receive understanding how that timing or the kinetics of infection response are essential and we've made a lot of progress on that over the last year

Mild Disease China Chronic Viral Infections
Tlingit art on postal stamp, and COVID surge in US

Native America Calling

03:53 min | 7 months ago

Tlingit art on postal stamp, and COVID surge in US

"This is national native news antonio gonzales the art work of a clinker artists from juno alaska will be featured on a new post stamp set for distribution next year henry show with cage. Ns reports rico. Lana world is the founder of trickster company a design shop based in juneau that incorporates traditional northwest coast art into everything from t-shirts and stickers to skateboard decks and basketball's he says that an art director for the us postal service called him up one day he had apparently discovered some of Tricks are companies are work at the national museum of american indians. Gift shop in dc and That's sort of where our discussion began about. Making this design happen world decided to go with the scene from the traditional story of raven setting free the sun moon and stars for his design and he says he kept a national audience in mind in other so many depictions of of raven. The box of daylight story It almost a little bit like silly to do it again. But i felt like it was an important kind of desire kind of story that that gets a gateway for people to to learn about cricket culture. His design depicts raven escaping through the chimney as he is transforming back into human form. It's an exciting and chaotic scene. There are stars stuck in his feathers and the sun is in his mouth. Orel says he believes the decision to include. His art work on a stamp is part of a wider movement for better representation of native stories. I think the usps is sort of in line with everyone else trying to figure out how to enable indigenous people to tell their own stories. And so it's it's just an honor to be able to be a part of that and to represent. According to sealaska heritage institute the postal service had planned to unveil the stamp at celebration twenty twenty but the event was cancelled because of the pandemic. shi is working with the agency to hold a release ceremony next year. In hanes. i'm henry leash across the country covid. Nineteen rates are hitting all time highs. No one knows that better than the healthcare workers fighting the pandemic on the front lines. Kale c. c.'s. Brian bull talk to his sister. Traveling nurse who's just recovered from covid. Nineteen my sister. Tracy and i are both proud members of the nez perce tribe or as we call ourselves than ame- pu we're also both essential workers during this pandemic though to be fair tracy's put herself in harm's way almost daily since nineteen came to the us still. She was surprised when she tested positive herself. I did a lot of sleeping but looking back the whole first week and a half was a blur it was an early november and thankfully tracy's case came at a later time in the pandemic one knowledge treatments. A covid nineteen or much better than on its earlier stages my sister got the same regiment as president trump. Actually but she says things got tense when the texas hospital. She does stain him. Tried to discharge her after only four doses of remdesivir contrary to cdc guidelines. I feel that they were trying to discharge me because they needed the hospital bed. And i told her no that i would not leave until i receive my sister. I insisted on it. Tracy's now out of the hospital ready to see her grandkids in montana. She says everyone needs to wear masks and appreciate healthcare workers. I'm very relieved. And of course proud of my sister be well. Keep doing great work and i love you. Happy thanksgiving thank you. I love you too. Brian and happy thanksgiving for national native news. I'm brian bowl. And tony gonzalez

Antonio Gonzales Trickster Company National Museum Of American In Free The Sun Moon Sealaska Heritage Institute Us Postal Service Juno Juneau Lana Kale C Rico Brian Bull Orel Alaska Henry Basketball DC Cricket Tracy
"remdesivir" Discussed on UN News

UN News

03:00 min | 7 months ago

"remdesivir" Discussed on UN News

"This is the news. In brief from the united nations patients with covid nineteen should not be given the antiviral drug remdesivir the world health organization. Who has said according to data from the who led global solidarity trial. There was no evidence that remdesivir had any important effect on people. Dying over reduce the ventilation will speed it up the time it took for them to get better nonetheless. Who said that there was no proof that the antiviral had no benefit at all and stressed that further trials should continue into whether the drug might be useful for more vulnerable patients. his doctor janet diaz head of clinical a-. Who speaking in geneva. We recommend a conditional recommendation. So i want to highlight that. It's a conditional recommendation against the use of remdesivir and hospitalize patients with cobra. Nineteen regardless of disease severity. This did not prove that remdesivir does not have a benefit at all you know. Is there a subgroup. That may benefit more such a severe patients versus critical patients. Is there timing and disease that may benefit more such as early versus late latest data from. Who indicates that eight and ten people infected with covid report mild symptoms while around five percent. Become critically ill. There are also reports of more persistent longer-term symptoms. Who said more than thirty thousand people have now fled ethiopia's tigray region to sedan in just two weeks amid ongoing fighting and the un says that it is planning for as many as two hundred thousand to arrive in an appeal for two hundred million dollars. Un children's fund unicef said that about forty five percent of refugees with children under eighteen. Most people left their homes quickly and with nothing. Although some have brought their animal's belongings and harvest said unicef's sudan representative abdullah. Fadhel people were scared. We saw panic and fear in the eyes of many children. He told journalists especially those who might have witnessed artillery fire or airplanes dropping bombs in reference to fighting between ethiopian government and tigray regional forces sudan coasts more than one point two million refugees and two million internally displaced people. You're in aid. Agencies have said that the number of people arriving in the country some four to five thousand a day is unsustainable and potentially has serious repercussions for the whole region to northwest syria. Finally where the un human rights office wage chr has expressed alarm at disturbing reports of unlawful killings by defacto authorities and the continued detention of civilians including humanitarian workers. H chr spokesperson brevine. Shoshani also appealed for the release of a twenty eight year. Old woman are shallow a humanitarian and media worker. She was detained by state group. Hit terrier al sham in recent days. It confirmed that it was holding her. On so-called moral and criminal charges miss chamdo sanni said that her family has not had any contact with her and that she may be at risk of execution noel shallows cases among many others that the un office has documented of individuals detained or abducted and executed in the northwest and other parts of syria over the past year. Daniel johnson you're news..

remdesivir un syria unicef sudan chamdo sanni tigray geneva janet diaz noel shallows ethiopia Daniel johnson Shoshani representative
WHO advises against remdesivir use

UN News

01:10 min | 7 months ago

WHO advises against remdesivir use

"Patients with covid nineteen should not be given the antiviral drug remdesivir the world health organization. Who has said according to data from the who led global solidarity trial. There was no evidence that remdesivir had any important effect on people. Dying over reduce the ventilation will speed it up the time it took for them to get better nonetheless. Who said that there was no proof that the antiviral had no benefit at all and stressed that further trials should continue into whether the drug might be useful for more vulnerable patients. his doctor janet diaz head of clinical a-. Who speaking in geneva. We recommend a conditional recommendation. So i want to highlight that. It's a conditional recommendation against the use of remdesivir and hospitalize patients with cobra. Nineteen regardless of disease severity. This did not prove that remdesivir does not have a benefit at all you know. Is there a subgroup. That may benefit more such a severe patients versus critical patients. Is there timing and disease that may benefit more such as early versus late latest data from. Who indicates that eight and ten people infected with covid report mild symptoms while around five percent. Become critically ill. There are also reports of more persistent longer-term symptoms. Who said

Janet Diaz World Health Organization Geneva Cobra
Gilead's revenue rises 17% driven by sales of coronavirus treatment remdesivir

Bloomberg Daybreak: Asia

00:12 sec | 8 months ago

Gilead's revenue rises 17% driven by sales of coronavirus treatment remdesivir

"Gilead Science has reported a revenue jump of 17% that was driven in large part by sales of the code. 19 treatment room disappear. Even so, Kelly had chairs right now down about

Gilead Science Kelly
Covid: US gives full approval for antiviral Remdesivir drug

Balance of Power

01:40 min | 8 months ago

Covid: US gives full approval for antiviral Remdesivir drug

"A Corona virus being a vaccine being available by year end. And yesterday, the FDA of granted its first approval for a treatment, not a vaccine, but a treatment room disappear to Gillian. Scarlett Foods here with some of the details, and, of course, from disappear is one of the treatments that President Trump was given. After he was diagnosed. We saw Gilead Sciences, the company gap higher at the open, rising as much as 4.9%. This is a drug that was originally developed to treat Ebola, and it's now become the first covert drug to get FDA formal approval before that it was available. Under emergency used authorization. So Gilly, I can now move forward with marketing the drug, The new brand name will be victory. I'm not sure why they're changing in. There must be something more to that. But given that everyone knows that, as from disappear, it's a bit of a puzzle to me. Gillian had said it would charge US hospitals about $3100 for most patients now in terms of the numbers, analysts estimate 2020 sales will be about $2.2 billion. Cos. Expected to sell 1.5 million doses this year. One blockbuster drug, of course, can make a huge difference for biotech firm and Gillian will need it because it's getting a lower return from its research and development. Then some of its peers only 40% versus a 42% at Vertex and Bio Marin. Now the FDA approved and disappear for emergency used back on May 1st. But if you look at the stock price, it actually hasn't done that. Well. It's fallen about 23%. Sadie Group says that Gilead has first mover advantage. But that only goes so far because The drug will provide a short term boost for revenue. But sales were actually taper off in the second half, when there's more competition from vaccines and anybody treatments are in development right now make so much the scarlet food for that

FDA Gillian Gilead Sciences President Trump Scarlett Foods United States Ebola Gilly Bio Marin Gilead Sadie Group
FDA approves first COVID-19 drug: antiviral remdesivir

San Diego's Morning News with Ted and LaDona

01:04 min | 8 months ago

FDA approves first COVID-19 drug: antiviral remdesivir

"The first antiviral therapy, toe win Food and Drug Administration approval as a treatment for the Copen 19. The FDA approval allows Gillian to market the drug that way, also disgusting the benefits with doctors, nurses and patients. The company says the drug wass in short supply at the start of the pandemic, But production is up, and it's now widely available in hospitals. All right, so that's on the treatment side. What about the vaccine side? Yeah, well, some outside advisers to the Food and Drug Administration question whether the agency standards are high enough. A panel of about two dozen experts met yesterday. Some members think the FDA needs to tighten its safety and efficacy criteria for emergency authorization for whatever vaccine eventually emerges. One panel of said kind of like this quote. What we're being asked to do is build this plane as we fly it. That's actually a great quote. Good. Let's talk about Facebook. Yeah, well, that could be the next big tech company to be looking at an anti trust

Food And Drug Administration Facebook Gillian
FDA approves Remdesivir as first treatment for coronavirus

WBZ Overnight News

00:24 sec | 8 months ago

FDA approves Remdesivir as first treatment for coronavirus

"Has approved the first drug to treat covert 19 rendez severe. It's a drug, which President Trump received during his treatment of Corona virus. CBS News Medical contributor Dr David Again check mark next to the drug thing. It's FDA approved. But I have over the last several months been able to and use this and patients in the right setting with Kobe 19 affection and this will continue.

President Trump Kobe FDA Dr David CBS
FDA approves first COVID-19 drug: the antiviral remdesivir

AP News Radio

00:42 sec | 8 months ago

FDA approves first COVID-19 drug: the antiviral remdesivir

"The food and drug administration has approved the first drug to treat the coronavirus rem de severe rem disappear had been approved for emergency use in the spring president trump pushed for months for fast final approval specially with things at work yes if you're is made by Gilly AT and study leader Dr Arun Sanyal says it's an antiviral drug given through an IV for patients needing hospitalization and it is designed to slow down or stop the virus from multiplying so once the virus cannot multiply anymore then the virus load goes down and the body's normal heating systems can take over a large study found ramp disappear cut recovery time by five days on average at Donahue Washington

Donald Trump Dr Arun Sanyal Donahue Washington President Trump Gilly
COVID-19: ‘little or no’ benefit from remdesivir: WHO

UN News

01:45 min | 8 months ago

COVID-19: ‘little or no’ benefit from remdesivir: WHO

"Results from a UN coordinated international trial looking at four cave nineteen therapeutics have shown little or no positive impact on preventing death in patients infected with new corona virus, the Solidarity Therapeutics Trial, overseen by the world. Health Organization who found that REMM disappear hydroxy chloroquine, Lapenne Aveer. Rootin- and Interferon. appeared to have little or no effect on twenty eight day mortality or the hospital course of covid nineteen among hospitalized patients. The study involved more than thirty countries and investigated the effects of the treatments on mortality ventilation and length of stay in hospital. It did not examine other uses of the drugs such as preventive treatment, which would. Require further trials in a related announcement. The WHO said that Covid nineteen had also highlighted the increased vulnerability of people with high blood pressure to the coronavirus. The warning is based on data for more than one hundred twenty countries showing significant caveat related disruption to treatment for people suffering from chronic health conditions with findings showing these patients make up fifty to sixty percent of all deaths through covid. Dr Bent Mickelson director of WHO's Department of noncommunicable diseases said that more than one point one, billion people around the world suffer from hypertension mainly in low and middle income countries when it comes to call it nine, thousand, nine, hundred, hypertension, one, hundred and twenty two countries that has reported. US that in over fifty percent of the country's the healthcare services disrupted fully or partially fifty percent of the country's, and in addition we see a high number of is we don't have global figures yet, but we see in the rain show fifty, sixty percent of the people that are severely ill and died in hospitals from code have hypertension diabetes, and so forth and the working on the global targets.

Covid Solidarity Therapeutics Trial Hypertension United States Dr Bent Mickelson UN Rootin Lapenne Aveer Health Organization Chloroquine Department Of Noncommunicable Director Interferon.
Remdesivir Fails to Prevent Covid-19 Deaths in Huge Trial

WTOP 24 Hour News

00:27 sec | 8 months ago

Remdesivir Fails to Prevent Covid-19 Deaths in Huge Trial

"It comes to preventing Corona virus deaths. A large multi national clinical trial shows one treatment. Rendez severe doesn't work. CBS NEWS Medical contributor Dr David Vegas. My God is it will still be continued to be used in many patients until we have something significantly better, but it's a very important study to realize that this drug is not dramatic in terms of treating covert 90 Grand desert here is one Of the drugs President Trump took after he contracted Cove it

Dr David Vegas Donald Trump Grand Desert CBS President Trump
Trump receiving remdesivir antiviral drug as part of experimental treatment

Weekend Edition Sunday

00:48 sec | 9 months ago

Trump receiving remdesivir antiviral drug as part of experimental treatment

"Trump remains at the Walter Reed National Military Medical Center after testing positive for the Corona virus and showing symptoms of covert 19. He's expected to remain there for a few days for treatment that includes the antiviral drug grim death Severe NPR's Richard Harris. This drug is designed to stop the virus from mats producing inside the body. And the FDA has authorised its use, but specifically for people who are sick enough that they need help breathing. You know when it was tried in people with mild to moderate symptoms that actually didn't seem to help, But I should say that observation was based on a small sample, so we don't really know exactly where this drug is useful and a video president Trump tweeted last night, he said. He is feeling better, but at the next few days of his treatment will be the real test. The video came after contradictory messages that cause some confusion about his condition.

Donald Trump Walter Reed National Military Richard Harris FDA President Trump
Trump given second dose of Remdesivir 'without complication', 'not yet out of the woods', Conley says

Scott Sloan

01:09 min | 9 months ago

Trump given second dose of Remdesivir 'without complication', 'not yet out of the woods', Conley says

"To Americans about his condition, President Trump's Saturday evening tweeting a four minute video of himself talking directly to the camera at Walter Reed Medical Center. I came here wasn't feeling so well. I feel much better. Now we're working hard to get me all the way back. The president was sitting at a table papers on top wearing a blue sport coat and white shirt, No tie, he says he's starting to feel good, but you don't know over the next period of a few days. I guess that's the real test will be seeing what happens over those next next couple of days. Karen Travers, ABC

President Trump Walter Reed Medical Center Karen Travers ABC
Trump 'doing very well,' has started Remdesivir therapy, White House physician says

The Moth Radio Hour

00:45 sec | 9 months ago

Trump 'doing very well,' has started Remdesivir therapy, White House physician says

"Trump is doing very well. That's according to Dr Sean duly at the Walter Reed National Military Medical Center, where the president is being treated for symptoms of the Corona virus. We have monitor his cardiac function. His Kidney function is liver function. All of those are normal, and the president this morning is not on oxygen, not having difficulty breathing or walking around. The White House Medical unit upstairs, Dr Julie says, While the president is not on oxygen, now, officials air, declining to say whether he has been since his diagnosis Thursday. They say they're continually a treatment regimen that includes antibodies and at least a five day course of Ram death Severe

President Trump Walter Reed National Military Dr Sean White House Medical Dr Julie Donald Trump
White House physician says Trump is taking Remdesivir and 'doing very well'

American Medicine Today

00:57 sec | 9 months ago

White House physician says Trump is taking Remdesivir and 'doing very well'

"President. Is doing very well. I'm Pam Crusoe Fox news that from his doctor Sean Conley moments ago as the president receives treatment at Walter Reed Military Hospital for the coronavirus, Dr Sean Connolly saying, I'm happy to report the president is doing very well. He's not requiring any supplemental oxygen but in consultation with specialist we've elected to initiate them disappear therapy he's completed, his first dose is resting comfortably. That is, in addition to the Regeneron antibodies that the president Not yesterday morning while still at the White House. So Regeneron medicine veer the two experimental drugs. The president's getting then zinc, vitamin D Pepcid melatonin and Aspirin is part of his regiment. That's what we know. So far. Fox is Leland Vitter. The first lady is resting at home after testing positive for Copa 19, a spokesperson said today. Her symptoms have not worsened.

President. Dr Sean Connolly Sean Conley Walter Reed Military Hospital Pam Crusoe Leland Vitter FOX White House Melatonin Aspirin
Trump receiving remdesivir antiviral drug as part of experimental treatment

Weekend Edition Saturday

00:50 sec | 9 months ago

Trump receiving remdesivir antiviral drug as part of experimental treatment

"Trump's physicians as the president is being treated with room to severe. NPR's Joe Palka reports. That's a drug usually reserved for hospitalized Covad 19 patients who are quite ill. Rendez severe, is an antiviral drug made by Gilead Sciences. It's administered intravenously, typically to hospitalize patients for five days, 10 days for sicker patients. So far, the best medical evidence suggests the drug reduces hospital stays by about four days. It's not clear if it prevents deaths from Cove in 19. An expert panel, convened by the National Institutes of Health concluded there are insufficient data to recommend either for or against the use of ram best severe in patients with mild or moderate cove in 19. The president also received an experimental monoclonal antibody therapy made by the company. Regeneron

President Trump Joe Palka Gilead Sciences Cove National Institutes Of Health Donald Trump NPR
Trump begins Remdesivir therapy while spending the night in the hospital

The Morning Show with Orion Samuelson and Max Armstrong

00:39 sec | 9 months ago

Trump begins Remdesivir therapy while spending the night in the hospital

"And the first lady announcing they tested positive for the Corona virus. Friday night, we learned President Trump's campaign manager, Bill Stepien and former adviser Kellyanne Conway have also tested positive. The president will spend the next several days at Walter Reed Medical Center outside Washington. As for treatment, the president has reportedly been injected once with an experimental drug combination to fight the virus. And he is on rendez severe therapy. The president posted a video statement on Twitter before boarding Marine one. I want to thank everybody for the tremendous support. I'm going too watery hospital. I think I'm

President Trump Kellyanne Conway Bill Stepien Walter Reed Medical Center Twitter Washington
"remdesivir" Discussed on Coronavirus

Coronavirus

04:35 min | 10 months ago

"remdesivir" Discussed on Coronavirus

"A daily Rhonda of today's top news stories. Here's your latest according to a new report from the American Academy of Pediatrics and the Children's Hospital Association nearly one hundred, thousand children in the United. States tested positive for the coronavirus during the last two weeks of July. The report says at least three, hundred and thirty eight thousand children have tested positive since pandemic began the report comes as parents and education leaders grapple with the challenges of reopening schools in the fall more than seven out of ten infections were reported from states in the South and West, Missouri. Oklahoma Alaska Nevada Idaho and Montana were among the states with the highest percentage increase in child infections. New York City new, Jersey and other states the northeast where the virus peaked in March and April, how did the lowest percentage increase of infections? The report noted that children rarely get severely sick from the virus drug manufacturer Pfizer has entered into an agreement with delete sciences the maker of from desert here to manufacture the drug at its facility. In Kansas, the move comes as run desert near a drug shown to speed up recovery in cove nineteen patients is in short supply some US hospitals have been forced. To ration the drug after a severe covid nineteen patients, Pfizer will be one of forty companies in North America Europe and Asia that will be making the drug jellied says it plans to produce more than two million courses of treatment by the end of twenty. It also says it plans to produce another several million doses of Ram desert in twenty twenty one if needed reservoir is an antiviral drug that failed as a treatment for hepatitis seat but was tested in nineteen patients. A federal study of one thousand hospitalized patients found it to be effective against the virus on May. First, the FDA gave the. Drug emergency use authorization allowing to lead to sell de Vere Jill lead says, the drug is difficult and time consuming to produce as it requires a long linear chemical synthesis process that must be completed sequentially include several specialized chemistry steps and novel Substances With Limited Global Availability. The price for a five day course of the drug costs more than three thousand dollars. Larry cudlow the White House top economic advisor struggled to explain trump's executive orders during an interview with. CNN. Go ahead it should be eight hundred bucks I beg your pardon it should be eight hundred bucks for the unemployment eight, hundred or four hundred. Now, it should be it should be eight hundred dollars. If. The states step up we're prepared to match that should come out four hundred dollars federal four hundred dollar states. kudlow wrongly stated that enhance unemployment benefits would come out to beat four, hundred, federal and four hundred by the state. However president trump's executive order it will only provide four hundred dollars jobless payments in which states are responsible to cover twenty five percent. Kudlow said the White House expect states to use what he described as considerable overflow of previous stimulus funding to pay for the unemployment benefits. Some experts have said states. Will Not be able to use those funds for this unemployment aid. Since it is a new program offerings by Congress, according to recent studies alleged proportion of the population upwards of twenty to fifty percent of people may have t cells that recognize new coronavirus despite having never encountered it before the T. cells which lurked in the bloodstream of people long before the pandemic began are most likely stragglers from pass couples with other. Related coronavirus including four that frequently caused common colds. The presence of t cells have intrigued experts who say it is too soon to tell whether the cells will play a helpful harm for or entirely negligible role against the current coronavirus. If the cross reactive tesol exerts even noticed influence on the body's immune response, they might make the deceased mulder and perhaps partly explained why some people who catch the virus become very. Sick while others do not and lastly a reopened high school in Georgia that drew national attention over images of its overcrowded hallways had at least nine new corona virus cases reported in the last week and the switching to online only instruction while the school is disinfected photo circulated last week showing students crowded school hallway controversy arose after a fifteen year old student who posted one of the images was suspended by the school. This has been a round of today's top news stories from today in America..

Pfizer kudlow trump executive American Academy of Pediatrics US Ram desert New York FDA Children's Hospital Associatio Vere Jill CNN Kansas Missouri mulder Congress Oklahoma West North America America
"remdesivir" Discussed on Today in America

Today in America

04:34 min | 10 months ago

"remdesivir" Discussed on Today in America

"A daily. Rhonda of today's top news stories. Here's your latest according to a new report from the American Academy of Pediatrics and the Children's Hospital Association. Nearly one hundred, thousand children in the United. States tested positive for the coronavirus during the last two weeks of July. The report says at least three, hundred and thirty eight thousand children have tested positive since pandemic began the report comes as parents and education leaders grapple with the challenges of reopening schools in the fall more than seven out of ten infections were reported from states in the South and West Missouri Oklahoma Alaska. Nevada. Idaho and Montana were among the states with the highest percentage increase in child infections, New York City New Jersey, and other states, the northeast where the virus peaked in. March and April how did the lowest percentage increase of infections? The report noted that children rarely get severely sick from the virus drug manufacturer Pfizer has entered into an agreement with delete sciences the maker of from desert here to manufacture the drug at its facility in Kansas the move comes as room desert fear a drug shown to speed up recovery in cove nineteen patients is in short supply. Some US hospitals have been forced to ration the drug after A. Severe Covid nineteen patients. Pfizer will be one of forty companies in North America Europe and Asia that will be making the drug jellied says it plans to produce more than two million courses of treatment by the end of twenty twenty. It also says it plans to produce another several million doses of Rome desert in twenty twenty one if needed reservoir is an antiviral drug that failed as a treatment for hepatitis seat but was tested in nineteen patients. A federal study of one thousand hospitalized patients found it to be effective. Against the virus on May first, the FDA gave the drug emergency use authorization allowing to lead to sell Rim Desire Jill lead says the drug is difficult and time consuming to produce as it requires a long linear chemical synthesis process that must be completed sequentially include several specialized chemistry steps and novel Substances With Limited Global Availability the price for a five day course of the drug costs more than three thousand dollars. Larry cudlow the White House top economic advisor struggled to explain trump's executive orders during an interview with CNN. It should be eight Hundred Bucks I. Beg your pardon it should be eight hundred bucks for the unemployment eight, hundred or four hundred. Now, it should be it should be eight hundred dollars. If the states step up, we're prepared to match that should come out four hundred dollars federal four, hundred dollar states. kudlow wrongly stated that enhance unemployment benefits would come out to beat four, hundred, federal and four hundred by the state. However president trump's executive order it will only provide four hundred dollars jobless payments in which states are responsible to cover twenty five percent. Kudlow said the White House expect states to use what he described as considerable overflow of previous stimulus funding to pay for the unemployment benefits. Some experts have said states will not be able to use those funds for this unemployment aid. Since it is a new program offerings by Congress according to recent studies alleged proportion of the population upwards. Of Twenty to fifty percent of people may have t cells that recognize new coronavirus despite having never encountered it before the T. cells which lurked in the bloodstream of people long before the pandemic began are most likely stragglers from pass couples with other related coronavirus including four that frequently caused common colds. The presence of t cells have intrigued experts who say it is too soon to tell whether the cells will play a helpful harm for or entirely negligible role against the current coronavirus. If the cross reactive tesol exerts a modest influence on the body's immune response, they might make the deceased mulder. Partly explained why some people who catch the virus become very sick while others do not, and lastly a reopened high school in Georgia that drew national attention over images of its overcrowded hallways had at least nine new corona virus cases reported in the last week and the switching to online only instruction while the school is disinfected photo circulated last week showing students crowded school hallway controversy arose after a fifteen year old student who posted one of the images was suspended by the school. This has been a round of today's top news stories from.

Pfizer kudlow US trump executive American Academy of Pediatrics Rhonda Rome desert New York Nevada New Jersey Children's Hospital Associatio FDA mulder Congress Idaho Kansas Georgia White House Larry cudlow
"remdesivir" Discussed on Little News Ears

Little News Ears

10:00 min | 11 months ago

"remdesivir" Discussed on Little News Ears

"The He. Four I am men's Brim. And I'm Jake Brims Dad, but some people call me boxer brew. And here's the news. Desert Brand Ram. What are you saying rim dizzy here I love. Talking about. Everybody today is may first two thousand, twenty today is a Friday and it's international. Well around the world. Yes in much of. Europe, for example, they tend to celebrate the holiday. Rendez Aveer. I still know what you're talking about. Why are you? Why are you saying that? Man. Who? was. The Laura. Who, who was that Guy i? Say Dad Rendez of years this new medicine that. Is. Helping. With the corona virus all that's that's very good news like curing it. No. But I think foul chief who is a very important prison right now he's basically telling us all we need to know about being healthy and social distancing and things like that. So He's the National Institute of Allergy and Infectious Diseases director is kind of like the health spokesperson for the United States now Did you see Brad Pitt imitate him on Saturday night live by the way Let's Focus Bram. Oh sorry. So I'm remm deserve here it's a medicine that basically if you take it and you're already sick with the coronavirus, you can get better faster maybe like it makes it speed up thirty three percent in some cases not at all to be tactical I. Think it was thirty one percent faster but maybe it's easier if we just say thirty three 'cause that's an easy number to remember kind of Oh but thirty two percent does not so much right thirty, three percent. That's like one in three right like if I have. three jelly beans in my hand and to are blue and one is red and reach, and you don't look right that's the same chance probability right yeah yeah. But it's a start, right? Doors. So I like about the Big Bang the Big Bang is really really cool you're and Then really the we talk about the Big Bang with the TV show. No give me. A loud noise like banging on pots. So the Big Bang is a theory that a long time ago like way longer than anyone was on earth when there was like, basically, there was nothing what how could that be there was nothing? Yes it was like magic just spaced. Void void is like nothing. So imagine a long time ago. There's no earth. There was no Mars. There was no son Oh. This is kind of scary. It's kind of weird. It's like two thousand, one's to. Remind. So anyway, is there was nothing at all except for this big dense. Like a ball of power and energy right I once heard it was almost like the size of a basketball and that that very very dense ball exploded. Oh okay. This is really weird. Is this like your imagination to know is very well known theory that I believe most astrophysicists. Because there's evidence for it essentially If you look at stars, they make redshift redshift. Essentially you can use a special kind of like a telescope..

"remdesivir" Discussed on Squawk Pod

Squawk Pod

07:06 min | 1 year ago

"remdesivir" Discussed on Squawk Pod

"Sure that that all patients would have access and based upon. Price level based upon the immediate savings in the healthcare system that this medicine provides based upon programs from the government whether you're covered by a private insurer whether you're covered by a government. Sure whether you're uninsured. With Cova Nineteen. There will not be an issue with access for disappear and just want to focus on that idea that there are two different prices a little bit because you. You're saying that Gilead needed to take a different approach during pandemic to pricing medicine, but did the the middlemen the insures the the folks that are benefiting from that difference between the the net price on the gross price. They don't see the pandemic as a time when they need to be thinking differently about drug pricing while I think I. I think the community at large is definitely coming together to think about how to make sure that patients with Kobe in the hospital system are well covered, and that's true from the government programs to the way, the private insurers of approaches to the way the cares program is there for the uninsured patient population so the way that the research based pharmaceutical industry has programs to make sure that if anybody needs support for their medicines, day received that so I think the system comes together the system. Is such that you do still have these two prices in the United States, but most importantly. I think the way that we price. This assures that patients will have access to this medicine regardless of how you're covered or not covered in the United States and ask you also about supply. This is a difficult medicine to manufacturer and you've detailed how the company. Company is working hard to increase the supply of it now you say you expect to have two million treatment courses by the end of the year HHS is now saying that they expect to get one hundred percent of your production of the drug, four July ninety percent in August ninety percent in September does the rest of the world. Get access to this. This medicine well once again mega want to really thank the colleagues that I had the privilege of working with Gilead that from the moment that we knew that this medicine may be effective in covid nineteen. We begin to ramp up a very complicated supply chain, which used to take twelve months from start to finish, and now as we enter into the second. Second half of the year we've reduced that down to around six months. What that means is that as we go into the second half of the year, we have kind of an exponential increase in supply, particularly starting in September October, November and December where of the two million treatment courses that cumulatively there'd be expect to have by the end of the year. More than half of those will be available starting from September on so. In the next several months where we have the greatest need in the developed world where the medicine is currently approved is here in the United States, so it makes sense to put a large portion of our supply. To work for US patients right now and as we go into September and beyond and we see where this disease goes in the developed world will be prepared with the supply that allows us to make sure that countries have what they need I just wanted to ask you about whether you'll you expect to make a profit under him? De Severe, you've said Geli ads expecting to spend up to a billion dollars doing all of this investment in manufacturing and development. Will you make a profit this year on the drug we'll make. Make I think that's a good question. I mean at the end of the day. We're well aware of our dual responsibility here, which is never one to price it for access. We really wanted to make sure that immediately. When countries have approved for this medicine that price in no way got in the way of patients receiving the medicine, which is why we priced it at a level for the if you like the country's, but the least purchasing power engaged every price to take away those government price discussions that exist accordingly. And at the same time we understand that we're at the beginning of our investment in disappear as you know based upon the three gold standard clinical trials, this is shown a significant effect in hospital patients, but we want to continue to see how we can increase that effect per by combining this with other therapeutics by bringing it earlier in the disease, and now we're. We're just going to be beginning our studies. The inhaled version of this medicine so that perhaps we can get it outside the hospital, so we're well aware of our total responsibility here in terms of our ability to both invest for access and continue to invest accordingly for the future, this medicine pandemic, all right Dan. We really appreciate your time. Thanks for being with us. SQUAWK POD we'll be right back. You're listening to Squawk pod. Here's Becky quick. What come back, everybody, a growing number of conic brands are pulling their dollars from facebook to take a stand against what they say is facebook's failure to stop hate. Speech Julia Abortion joins US right now. She has more on this story. Juliet Good Morning. Good morning to you, becky well. FACEBOOK shares plummeted more than eight percent. Friday group of smaller companies organized by the end W., C., p. and anti-defamation league calling on facebook to crackdown, racism and hate. Speech has grown into a boycott of facebook by major brands starbucks, which was facebook sixth biggest advertiser in the US last year, spending an estimated ninety five million dollars according to. To Path. Matic's joined Honda Coca Cola. Unilever rising in smaller brands who said they would pause advertising on facebook now over one hundred and fifty companies have committed to a one month pause as part of the official boycott others leaving the pozo open ended while proctor and gamble is just saying that it's reviewing hate speech on all the platforms and reconsidering all of its. Its AD spending now analysts saying that more brands could influence others to join. Some of these big brands can influence others to join. That could expand internationally and Bank of America saying that they expect facebook to tighten restrictions on hate speech in possibly introduce some new fact checking policies now, the growing number of advertisers participating indicate that Zuckerberg's latest efforts didn't go far enough Friday. Friday he announced. FACEBOOK is cracking down on hate speech in ads, and we'll label incendiary post by politicians now as brands who are under economic pressure. Look to cut their overall spending. One question is whether they can realize that. Maybe they don't need the social platform as much as they thought that they did. Becky Julian just in terms of the economic impact of this. What's the guests at what it could be now that we've seen some of these big brands that are saying this is how permanent do you think it might be? And how difficult will it be for facebook to address some of these issues and try and win those customers back? We'll look right now. They're trying to address issues they're. They're trying to figure out. How both highlight the work that they've already done. and which changes they feel like are appropriate to make just making it look like they're caving to pressure in terms of the economic impact, I mentioned. starbucks has about one hundred million dollars in spending on facebook last year. Now that's just the US number. The.

facebook United States Becky Julian Gilead Cova Nineteen starbucks HHS Kobe US covid Geli Unilever Dan Julia Abortion Juliet Matic Bank of America
"remdesivir" Discussed on Squawk Pod

Squawk Pod

11:01 min | 1 year ago

"remdesivir" Discussed on Squawk Pod

"Any money at in the few times that they can fill up a plane so that it is a quote profitable flight. That's what they're doing on average however the average number of passengers on a plane right now is about seventeen and the problem is this you get too many planes and too much staff for the airlines. Take a look at Delta today. It said it's going to be retiring. All of the Boeing triple seven planes that they fly those are primarily on their international routes. They're also telling their pilot. They have fourteen thousand of them. They have seven thousand too many for the schedule that they are setting for the fall. Scott peter defazio would love to see the airlines. Make sure that the middle seat is always unoccupied and limit the number of people on a plane to no more than two thirds of the seat. If that were to be the case a hundred percent across the board the airlines would not make money. Fill a somewhat sympathetic. You know many are to the plight of the airlines right now. It just seems completely unacceptable. Some of those photos coming out of airlines. That are packed and people are clearly uncomfortable. There's not social distancing at all it just making people really uncomfortable and that's the point representative Defazio and that's why he's saying at a minimum. You need to have the middle seat. Empty so the question then becomes. How did the year lines turn a profit? Well if you're going to keep that middle seat empty and represented the Facia says go ahead and charge more for an airfare ticket for a plane ticket but you know how much more you'd have to charge Scott anywhere between forty fifty and sixty percent so now the the fair that might be a hundred eighty dollars turns into three hundred dollars and that has the impact of telling making people say I do. I Really WanNa take this light. Yeah maybe not right now. And that's the last thing the airlines need right now. Yeah I'll tell you what though could also though these sorts of pictures that we're looking at right now could backfire on the airlines in and of itself fill in that people who are seeing this right now are going to say you know. I was thinking about taking a flight but now I'm not if that's what the airlines are doing. So they're missing out on the money anyway. If people see these photos and don't fly absolutely it's all about comfort level in right now very very few people comfortable flying in the US if some of these planes though are packed the photos don't lie. Phil appreciate it very much. Thank you Philip Tonight. Here's what else is coming up on this. Cnbc special report this table. One thanks to go one. Restaurant owner rearranging seeds for reopening. Shows us? How he's doing it plus a first look at what your office will look like when you go back doctor now. Making arrangements for offices big and small shows us his strategy. We're back in two minutes rearranging America from offices. We need to be feet apart to restaurants what it will all look like. It's the new path forward for America this. Cnbc special report continues once again. Here's Scott Wapner. Welcome back. Let's get another check of futures at this hour after today's Wall Street rally. Pretty good turnaround on the street today. And we're turning around the futures as well a B. It slightly. We are in the green though across the board as four today. Those same green arrows. The Dow rising three hundred seventy seven points up for the first time this week. The strongest sector today add to be financials FIF- gains for American Express. Wells Fargo J. P. Morgan and Goldman Sachs all for a change helping the Dow. Well when restaurants open for sit-down service. We're going to see big changes. Of course tonight. What one owner is doing to get ready for that? It's a scene playing out behind closed. Doors at thousands of America's restaurants here's Andrea Day armed with an infrared temperature gun chef Rafael. A run is ready for the day. He can do business again when somebody gets into the door temperature. The needle never fever unwise. They're not it into your business. This chefs to New York restaurants. Shut DOWN TO DINERS BACK in March. This one is located in Westchester County. One of the state's earliest hotspots. He's okay you can work in any seven points. It's all part of the new protocol guidelines for re opening after Cova nineteen a documentary just received from his town's Chamber of Commerce. It's all designed to help virus proof every inch of his three thousand square foot eatery menu that everyday we used to clean sanitized. Make sure they were Nice presentable. Now throw away just like paper that once you know somebody touches declined touches it. It's just toss out in the garbage so this used to be our check presenter. No more because it's plastic. You cannot have. It uses the new way of presenting. Check your you go. All staff have to wear masks while they're working on when we all the seats at the bar have to he free fourteen barstools get carried away protocol. We need to be six feet apart. This Day passed the move forward. The restaurants tables are also getting the Cova treatment to have to go seeing shrinking down by chairs number of tables. It's quite diverse. It just hurts your heart. We need to do all this changes to lakeshore than our clients. Come out and feel safe. In the end chef Rafael carries away. Eleven of the nineteen tables and more than half. The chairs are gone total seats on the front of the restaurants. Where Ninety seats now. We're at forty one and this new normal will be tough on the business expenses that we have we would have. We would have to move out two hundred people a day so you have to turn this four times which is almost impossible to see because everybody wants to between six thirty thirty. The numbers are stacked against him but he says he's ready for the challenge. This is a new business plan. We're going to give one hundred ten percent sure that we survive and see the light of the other side of the. We have only one choice to succeed. We're rooting for you. Chef I'm Andrea Day. Cnbc Andrea thank. You we certainly are rooting for everybody. So that's the restaurant side of the story. Now Dr who is rearranging office space. Dr Robert Quigley is the senior vice president and Regional Manager for the Americas at International SOS. It's a company that provides medical consultations and services to workplaces DR quickly. Good to have you on our program tonight. We actually have blueprints of an office space from before and sort of after an ongoing project that you're working on. I'M GONNA put those on the screen. I'd like you to talk us through. What the new office so to speak is going to look like on the other side of this certainly and this office is clearly representative of many offices across America right now and the request that we are getting international last from organizations in every sector is. What do we do how to reopen up and we always begin by saying look? It's it's GonNa be like a dimmer light switch. He's not going to be an on off and what you see on the screen in front of you is a before. And after appearance of basic layout that we have proposed to mitigate against transmission of the corona virus in the new office but that is just a static picture wrapped to understand that there will be many protocols procedures that are shared between us and our clients with regards to practices. And what we've done is we've broken down the project if you like for all of our clients into employees infrastructure and then guest visitors vendors and we address each of those groups of people all of whom are potentially at risk as carriers. You look at the screen in the after appearance you can see how we encourage a single point of entry represented by Poe on the screen when one walks through that single point of entry. There's a screening station which may or may not be a manned by a healthcare professional. Typically not we do suggest to set the organization Alexa Hygiene Ser. Who is at least up to speed on? What are the appropriate questions? It should be asked in the event the individual comes in and they have a fever. We also have a room near that point of entry which we call the red zone and that's a room where one would be delegated if one at a fever and from there we have connected. Medical Emergency Response plans vigil to be assisted out of the workplace or going through ems. What I what I notice from from looking at these pictures it appears to me. Is that the office. Space itself is the same size. We just have a fewer number of people within that space as we have been thinking about. What the office itself would look like in the future and whether companies would actually be taking smaller footprints in a commercial building this suggests otherwise. Well it doesn't. It doesn't if you look at it closely. You can see that what we've done is we've tried to maintain that fundamental principle of the social distancing. So we've separated. What might be a quadrangular desk arrangement down with double or if you have a desk arranger that are long tables and chairs. We alternate Seats and we have been able to do that already in a variety of places and that seems to work very well so we don't necessarily have to cut down on the top graphic square footage as much as we have to carve out pathways and opportunities where one is not going to breach the basic at two meters six foot social distance principle which we know is so fundamental obviously in the context of universal precautions wearing a mask and washing one's hands and having sanitizer which we have located all over that particular blueprint in front of interesting work ahead for all of us as we think about this. Daca quickly. We appreciate your time so much. Thank you very much. Thank you I appreciate you joining US tonight. Here's what's next on this. Cnbc special report. He's demand behind one of the world's most iconic clothing brands. Joseph Abboud is with US next on the future of retail before the break images from around the world on the one hundred thirty seven day of the global pandemic.

America Cnbc Scott peter defazio US Andrea Day Cova fever representative Philip Tonight Boeing Delta Westchester County New York American Express Scott Wapner Joseph Abboud Goldman Sachs Facia
"remdesivir" Discussed on Squawk Pod

Squawk Pod

04:25 min | 1 year ago

"remdesivir" Discussed on Squawk Pod

"remdesivir" Discussed on Squawk Pod

Squawk Pod

08:29 min | 1 year ago

"remdesivir" Discussed on Squawk Pod

"Evening. I'm Scott Wapner on day. One thirty seven of the corona virus crisis the nation's former vaccine chief tonight with an ominous warning for the country. Twenty twenty could be darkest winter in modern history. The doctor charged with finding a vaccine for the virus. Demoted by the White House. Speaks out our window of opportunity is closing tonight his plan and what the CDC is proposing plus new fears. This country is in for a shortage of a drug. Many think. We'll stop the virus and we need to be six feet. Apart this table got to real ranging America this CNBC. Special report markets in turmoil starts right. Now here's Scott Wapner. It is good to have you with us on this Thursday night after the Dow snap three straight days of losses. Let's get our first look this evening at futures right now. It is early of course and they are modestly lower across the board stocks though. Shrugging off more dismal unemployment numbers and erasing early day losses. Today the Dow rose more than three hundred seventy five points after being down more than four hundred. Fifty early on financials were the best performing sector for a change. American Express rising more than seven percent late this afternoon. The New York Stock Exchange said it will reopen the trading floor to some of its brokers on May Twenty six today in Washington ousted vaccine official rick. Bright taking center stage testifying before the House health subcommittee. Warning the government's current response to the corona virus could lead to even deadlier months ahead. We are facing a highly transmissible and deadly virus which not only claims lives but also disrupts the very foundations of our society. The American healthcare system is being taxed to the limit. Our economy is spiraling downward and our population is being paralyzed. By fear stemming from a lack of a coordinated response and a dearth accurate clear communication about the path forward. I fear the pandemic will get worse and be prolonged. They'll be likely a resurgence of Kobe. Nineteen this fall. It'll be greatly compound at by the challenges of seasonal influenza without better planning twenty twenty could be the darkest winter in modern history. First and foremost we need to be truthful. With the American people. Americans deserve the truth. The truth must be based on science. There is no master coordinated plan on how to respond to this outbreak. We don't have a strategy or plan in place that identifies each of those critical components and we don't have a designated agency that is sourcing those critical components and coming up with a strategy to make sure that we have those supplies when we need them. Cnbc CONTRIBUTOR DR Scott Gottlieb with us once again he is the former head of the FDA. Of course Dr Gotlib. Welcome back the explosive testimony from Dr. Bright is where we begin tonight. What was your biggest takeaway today? Well look I think Rick's right in so far as we face challenges ahead with this pathogen. It's not going away. This is likely to come endemic. I think the tools we're going to have in the fall a very different terms of dealing with this. We're GONNA know how to contain outbreaks in the fall. Hopefully we'll have much better testing in place. Certainly we'll have one more drugs available to US eventually. We'll have a vaccine probably towards later in the fall that will be able to use but this is going to circulate and as this collides with flu season will likely face challenges trying to differentiate corona virus from flow and. This is more contagious than the flu. So if this is left unchecked which it won't be but if it's left unchecked we could face another epidemic heading into the fall now. I think we're GONNA be in much better shape to try to grapple with that and prevent it but those are the risks. Do we need a moore master and coordinated plan as Dr Bright suggested today up till now most of the critical decision making Dr Gotlib has been left as we know to the states. Do we need a moore master coordinated plan from the Federal Government? Well look I think at this point. The states have done a good job. I think it's likely to remain. A state led effort and I think the states are in a much better position going into the fall to know what they need. What we're likely to see in the fall is rolling out breaks. I don't think that we're to have another national epidemic. I hope not. I think we're in a position to try to contain spread but we're likely to see rolling outbreaks where cities become epidemic or states have large outbreaks. And then it becomes incumbent upon local officials to implement to try to control those outbreaks. And so it's not necessarily a national response. It's going to be a state by state response. My one concern is that no state wants to go first and so if you're a city that has now braked you want to be the city that shuts down your airport or your economy to try to contain spread within your city to put to create safety for the nation as a whole and we saw with. Seattle. Seattle is very reluctant to take those measures when they should have. San Francisco is really the first city to implement those tough measures and so hopefully by the fall. Governors and mayors will be in a position to take more aggressive action earlier to try to contain spread. If they're the ones that have that outbreak we're finally getting the CDC reopening guidelines. We've been waiting for those a Dr Gotlib to deal with schools and workplaces camps childcare mass transit bars and restaurants. How strictly should states be following those? Well they're they're greatly scaled back in terms of what we were expecting. And what the draft documents said that were leaked unfortunately to the Washington Post but we gotta look at those draft because the reporters got a hold of them and what was essentially released. Were some of the figures if you will in those documents some of the flow charts and so it's not very specific guidance system businesses and I've been talking to a lot of business leaders who are now developing their own guidelines on their return to work what they plan to do in the workplace and what they're generating is far more specific far more granular more detailed and frankly more aggressive than what's outlined in those flowcharts. Cdc It's not clear this represents the totality of what CDC is going to put out but if it does. This is pretty much top-line guidance what the businesses are going to do is GonNa go well beyond this. You use the word greatly scaled back. Does that put more people at risk doctor. Well it's it's not as helpful as it could be. I mean I think what you want. From public. Health officials is more detailed guidance that provides more granularity more specificity. To businesses businesses now need to make decisions about how to implement hygiene and workplace how to implement social distancing how to how to create a staggered workforce. So that you're not bringing people together in groups how to implement testing in the work site if you want or make it available the guidances would put out tonight really the flow charts. That will put out tonight. All make those recommendations they say. Businesses should engage these activities. But they don't provide a lot of specificity on how to do that now they link back to Information Soriano. Cdc website so that's a little bit more granular but it's not specific to the workplace and so businesses now need to go beyond these flowcharts. He's flowcharts are sort of top lying. These are the things you should be thinking about now. Business need to implement more detailed plans on how to achieve these goals. Sounds like business is going to be left to itself much like the states where to try and figure this out on their own including how to deal with children back to school. Which New York's Governor? Cuomo today said he's unsure whether schools will be able to open in September. Do you think they will? I think it's too early to tell. Look it's going to depend on what July and August look like and if we head into July and August and the infection rate does come down. There's a seasonal here. We believe that will be a seasonal effect. We don't know how powerful it will be but if the infection rate does come down heading into July and August and we'll coming off of August where there's not a lot of background infection. I think there's going to be an attempt to reopen schools in the fall now. Schools may take certain measures to try to reduce the risk. They may stagger classes. They may have students work from home one or two days a week. They're going to try to create physical separation. They may try to expand their campus. So there's things schools are going to do but I think they'll attempt to reopen schools. And then we'll have to see how this progresses if we have outbreaks around the country in certain regions in certain cities in certain states. I think you'RE GONNA see rolling school closures. Hopefully we don't get to the point where.

CDC Dr Gotlib Scott Wapner CNBC Seattle Dr. Bright Twenty twenty White House DR Scott Gottlieb America US flu New York Stock Exchange Washington Post seasonal influenza Federal Government House health subcommittee San Francisco Rick
"remdesivir" Discussed on Coronavirus

Coronavirus

04:04 min | 1 year ago

"remdesivir" Discussed on Coronavirus

"In thanks for tuning into latest current ivars updates. A total of sixty four thousand Americans have died from Corona virus and confirmed cases in the country have just passed one point. One million. The World Health Organization has extended its declaration of a global health emergency as global death. Toll reaches a quarter million the move three months after the organization's original decision to announce a public health emergency of international concern on January thirtieth at the time only ninety eight of the nearly ten thousand confirmed cases at occurred outside of China. The growth rate of the virus has slowed down in many Asian and European countries. But there is much concern over a rapid rise in new cases in Africa and South America where many countries have weak healthcare systems. That could easily be overwhelmed across the United States. Governors are struggling to keep stay at home owners and place amid rising demand from protesters to reopen the economy scientific in public health experts warned that reopening business restaurants movie theaters and malls to a deadly second wave of the pandemic the FDA has approved the emergency use of Ram Desert. Here an antiviral drug. That seems to boost recovery among Cova nineteen patients. Fda Commissioner Steven Hand said. The approval was made at Lightning. Speed calling it an important clinical advance the agency based its decision on the results of a government study that showed desert shorten the time to recovery by thirty one percent for Cova nineteen patients in the hospital. Those given the drug were able to leave the hospital and in eleven days on average versus fifteen days for those given placebo earlier this week. The White House announced an initiative to produce a cove nineteen vaccine. That could be available nationwide as early as January. Dr Anthony Fallacy said that the initiative coined operation warp speed would produce hundreds of millions of doses by January the CDC has announced a national initiative to speed up research on how the virus was spreading across the country bringing together at least seventy five public health institutions to study the virus genome understanding the genome can help scientists trace patterns of transmission investigate outbreaks and better assess the accuracy of diagnostic tests and the effectiveness of treatments and Vaccines Treasury Secretary. Steven MNUCHIN says private. Schools with large endowments should we turn federal stimulus loans? They received from a program intended for small businesses hit hard by the krona virus. Pandemic many prominent private schools have applied for the loans which are issued by the SBA to how businesses meet their payroll needs. Some schools such as Harvard have decided to return the amid public scrutiny. But others say they need the money the Los Angeles Times reported that a private school in Los Angeles attended by two of Mr Mnuchin children had accepted alone run by the SBA. The six hundred sixty billion dollar aid program formerly known as he paycheck protection program has been criticized for providing funds to large public companies ahead of mainstream small businesses. The money comes in the form of SBA BACKED LOANS. That can be forgiven. Recipients put the majority of funds towards payroll needs and lastly a new report from the CDC shows that more than four thousand workers at one hundred fifteen meat packing plants across the country have been infected with corona virus. At least twenty of the meatpacking workers have died from the virus. The news comes. President trump issued an executive order labelling meat processing as critical infrastructure enabling the Department of Agriculture to take additional action and keeping plants open superseding local regulation in total the meat and poultry processing industry employs about half a million people over the last month. Dozens of meat packing plants have been forced to close amid outbreaks straining. The country's meat supply..

World Health Organization Steven MNUCHIN FDA CDC SBA Corona Cova Los Angeles Times United States Ram Desert Harvard China Africa Dr Anthony Fallacy Los Angeles Steven Hand White House Commissioner
"remdesivir" Discussed on The Highwire with Del Bigtree

The Highwire with Del Bigtree

09:24 min | 1 year ago

"remdesivir" Discussed on The Highwire with Del Bigtree

"I want to tell you folks I don't want to tell you. This is who is running all of the medical decisions for the United States of America. This is his own personal study right and by the way. I'm not the only one that had problem with that. And packed with tipped us off to even look at clinical trials dot Gov was the virologist Dr Ddr riot in France who again is jumping up and down saying what kind of study is this. And why did you just hear? He pointed out could Anthony Fouled. She explain why the investigators the NAIAD RAM disappear trial did change the primary outcome during the course of the project April sixteenth. Removing death from primary outcome is surprising. Decision you're right about that. You're right I think that is a surprising decision. And what would make them make that kind of decision I mean? Could it be that? There were other studies around the world. That maybe weren't doing what they needed to do or showing what they needed to show. Actually there was the. Who Accidentally Oh. This is one. This is actually different stuff. The Lancet rim desert adults with severe. Kobe randomized double blind placebo. Controlled multicentre trial. What did you find out interpretation in this? Study of adult patients admitted to hospital severe Kobe. Nineteen desert was not associated with statistically significant clinical benefits. Now then we have this deal yet. Tumbles after latest data leak on Virus Drug Trials April twenty third. So this is all happening right. This is happening while bow-ties in the middle of his study in the Lancet publishing. What's going on? But then the WHO leaks out of twelve. That's not even finished in China is going on. And that was that the headline we're just looking at Dealey ads now tumbling because it is showing that you have what appears to be maybe an increased rate Gilliat shares. Where whip saw the second time in week after summary of Chinese twelve it's cove in nineteen drug appeared to show that it was a failure the World Health Organization which has been helping. Coordinate the global response to the virus said it accidentally posted the results on a website. That helps track therapies for the disease. Oh whoops we showed you. It's a failure. Sorry about that. Gilead quickly removed but details the Post reported by the Financial Times and posted by the publication stat. They showed that the drug wasn't associated with patients. Getting better more quickly and thirteen point. Nine percent of patients getting into drug died versus twelve point eight percent getting standard care so more people died. The study in question was one of two main trials in China for desert and looked at patients with severe cases. Kobe nineteen this group was considered one of the hardest to treat with antiviral drugs. Since by the time the disease becomes advanced. There may already be significant lung damage. In addition the immune system may spin out of control in some patients with advanced disease. A process that antibiotic liked. Gilead drug won't help with now. You'll add statement said the trends in the data suggest. Potential benefit from does desert particularly among patients treated early. The company said to the full data are being submitted for review and Publication. Follow Statement. The company said the data add to a growing but still inclusive body of evidence for room. Desert expects full results from the other two trials larger studies at the end of May. So what it's saying is our other trials that are going on. We expect to get a better outcome. We're hoping for a better outcome than this one which was described as a complete and total failure. By the way it looks like one of those other twos is already gone as I told you. They canceled this trial. That is being reported right here. That was a total failure. Probably because they realize we're killing people. We needed to stop this trial the other trial which had people starting Kobe. I mean starting to treatment earlier. It's been suspended so it looks like as far as we can tell it might be wrong. The only trial. Everyone's counting on now program desert is being done by Anthony Pouch himself. But let me point something out right. One of their complaints about how that study was being done. It was only on the severe patients who are most likely going to die anyway. So it wasn't really fair to reservoir Interesting why that is what we report when it's Rim desert beer but when that's the exact same case in the hydroxy chloroquine trial. We look the other way. I mean. Honestly folks this is seriously suspect. Isn't it you're already manipulative? Placebo Group and then you know these other. Trials are not turning out right. Is that why they start. Bolstering THEIR MOUTHS REMEMBER. They used the term statistically insignificant in in in the land saying it was statistically insignificant if there was a benefit at all. Well that what I say. Why would you start adding more people to try and see if you can add in and get enough statistical significance? All I'm saying is. I think it's clear that there may be some bias going on hold on. I mean told something right and so what it really lets us know is that Gilead a pharmaceutical company and NIH who works really closely owns its own patents to things is involved in what appears to be helping pharmaceutical companies. Is it possible that REMM desert just being put forward because you can charge more money? Maybe maybe that's the case we all know. This is the problem with cancer therapies. Right if it ends up being a vitamin nobody can make any money. You're never going to hear about it. Nobody's going to spend millions of dollars. Trials is that why they're trying to bury hydroxy chloroquine along with the fact it's GonNa Make Donald Trump look really bad. That's another added benefit right so number one. We can't charge for it number two. You know it's going to route. Donald Trump look really bad and for those of us that are on CNN and MSNBC and all the channels that are really funded in most part by the pharmaceutical industry. It makes us all look good. I'M GONNA throw out one more theory just because it's really odd. When you look at this you see when you look at all the hydro chloroquine hydroxy chloroquine studies all around the world. One Thousand Ninety nine percents success rate. You had a doctor in New York. I'm forgetting his name right now. Who had eight hundred people he treated? The LINKO had eight hundred people treated and said nearly one hundred percent. Success rate doesn't China's showed that hydroxy chloroquine was having nearly one hundred percent success rate. So you had the opposite right. What you have is successful trials everywhere but the one that about she cares about the FDA care about there was really done poorly by the va on a very specific population. That were already dying. We're going to make that raise all the great studies everywhere else. Now we reverse the thing right and now we're GONNA try to hide all the studies around the world. They're showing. The reservoir has almost no effect whatsoever and may actually kill more people. We're not sure. But it's statistically insignificant in a Lancet published study and. We're going to try and override those bad studies with the one being done by WHO? Dr Anthony Found and I was asking myself this and here by the way I show you facts right. I hope you know the difference between we're showing you things from a trial and then when we talk about theories. I have a little theory here you know. It may not be true but we're thinking about bias remember how badly they wanNA vaccine right. Anthony Power to keep saying really wants to normal life. Do we have a vaccine? I've talked about the Vaccine Unicorn. Whol STILL. You're not going to have a normal life until you have a vaccine everywhere. Bill Gates goes. He says you're not going to have a normal life until we have a vaccine which made me think well. Then why would they be keen on Rim desert here? You know I mean why are they going? I've been sort of speculating that they really want this vaccine and a great treatment like Hydroxy Colin Quinn. Been successful or racist the need for it right. If you can cure that you know five percents that are gonNA be severe and the point one two point three percent. That may actually die if you can cure them with hydroxy chloroquine the vaccines over. What if you recognize that? There's a drug that and remember what Bill Gates had right. Show me a drug. That's ninety five percent effective and then maybe then we can that. We don't need a vaccine as though he knows something right. Does he know that REMM desert fear is actually a really crappy drug. Is it possible? Is it possible that what we're hearing your records records all around the world of ninety nine percent effectiveness with hydroxy chloroquine? That what Anthony. Bounty is so excited about in this trial is this may have like a fifty percent success rate. We can maybe even cure if we put enough people in trial. We can take a statistically insignificant infinitesimal gain and make it seem like it's okay. Well thirty percent of people were healed now remember. It's only good enough. We're going to have to wait for the vaccine to really protect ourselves. I'm just saying folks. I'm just saying if you like that clip and be sure to check out our live broadcasts of the high wire every Thursday morning at eleven. Am Pacific Time. You can watch it on facebook youtube. I tunes and twitter. We'll see you there yeah..

chloroquine Kobe Desert Bill Gates Dr Anthony Anthony Fouled Rim desert China United States Donald Trump France Lancet World Health Organization America Financial Times Anthony Power Anthony Pouch facebook lung damage
"remdesivir" Discussed on The Highwire with Del Bigtree

The Highwire with Del Bigtree

14:19 min | 1 year ago

"remdesivir" Discussed on The Highwire with Del Bigtree

"Well okay you don't like hydroxy. Do you like something else. Maybe that costs more. Here's one of the things we heard that does show some hope. As far as Anthony. Pouches concerned the data shows that Desa density has a clear-cut significant positive effect in diminishing the time to recovery. This is really quite important for a number of reasons and I'll give you the data. It's highly significant. If you look at the time to recovery being shorter in the Rendez Aviram. It was eleven days compared to fifteen days. That's a P value. The scientists who listening of zero point zero zero one. So that's something that although with thirty one percent improvement doesn't seem like knock out. One hundred percent is a very important proof of concept because what is proven is that a drug can lock. This virus really wanted to take this infra second because I think him out to blow your mind. Does that sound like a very different approach to discussion about this drug compared to what we heard him say trump. I wanted to say. It's anecdotal right now. We really don't hydroxy chloroquine. I know that I know. I know the president's got a good feeling about it but I really want to caution. We should think about this. We don't know how else I mean. Honestly and then here is very promising. This is promising. This drug from desert here is really showing a lot of promise. And as though like there's one hundred studies that are rocking it out around the world right. I mean clearly rendez of your you know must be awesome now. Let me make this perfectly clear. I've been touting. We should be desert beer. Trials should be trying everything I wanNA find. Whatever it is that works because once you have a treatment even Bill Gates said. Hey find a treatment. That's ninety five percent effective then we don't even have to worry about a vaccine Bill Gates. Who by the way is telling you we're going away for vaccine and he is pretty darn sure. We're never going to find a drug that can be ninety five percent effective while I'm getting a little bit off track and you get used to be following this. You do realize that Dr Erickson in every other decent scientists in the world has already said ninety. Five percent of healthy people will recover from Kobe. Nineteen with no side effects whatsoever. So wait a minute. Hold on a second ninety. Five percent of people to be ninety five percent effective in order to skip a vaccine but nature itself. Immune system is ninety five percent effective. Killing this thing moving on most of us will get a cold some of us. You know maybe even more dramatic. I mean. This is what you've got to start looking at he right. Let's back Rim desert so what's going on with Remedies Abi Right. We all have to say God. Everyone's so excited. We're hearing the news that this great new thing it says. Dr Foudy says Rim desert trials shows drug has promised is FDA plans to announce emergency use. Fda's telling you stop using hydroxy chloroquine move over to Ram desert here all right. I WanNa take you through the only trial right now that we can find that's currently going on. Oh by the way. Guess WHO's doing the trial. Naiad the NIH Naiad being the specific branch. Right here. There it is National Institute of Allergy and Infectious Disease Who's the head of that? Oh wait a minute that's doctor. He's doing the study himself. No what are you so excited about. And wonder he actually knows that studies going on right now is showing so much promise. He's the one heading this study. Okay let's give them the benefit of the doubt right are really wanted to give them benefit out remember. Maybe he's not biased. Maybe doesn't have anything to maybe having CNN MSNBC. And everybody's saying you're the hero because you were right about hydroxy. Chloroquine has nothing to do with this. Let's take a look at the study shall we? You can find all this on. Clinical Trials Dot Gov first of all on February twenty first they laid out how the study would work percentage of subjects reporting each severity rating. On the seven point ordinal scale. Okay so they're gonNA have a seven point scale that would lay out all we were looking at. The ordinal scale is an assessment of the clinical status of the first assessment of a given. Study Day. The scale is as follows. One will get one category. I want to be very clear at one. Category is death. How many people die. We just heard the other studies showed how many people died in the chloroquine. Study a number to hospitalize basic mechanical ventilation or extra correal membrane oxygenation. Cmo number three will look at hospitalize or not. Non Invasive ventilation or high flow oxygen for hospitals requiring supplemental. Oxygen Five hospitalized not requiring supplemental oxygen six not hospitalized limitation on activities seven not hospitalized no limitations on activities. These are all the seven groups and very thorough trial. There apparently GonNa going to look at and how many people are going to be a part of mistrial we listed. Do we have that number? O- other than white hundred ninety seven substation each arm for a total of three hundred ninety four in this study. Now those of you that have seen my film back you remember that one of the issues that really was at the forefront of a whistle blower at the CDC named. Dr William Thompson was after. They had the study design. They started manipulating and changing the study. Okay now that's something. That is what really leads to being considered fraud. That's a fraudulent scientific. Study you can't start changing the amount of people on a study. He can start kicking people off. You can't change the groups you're looking at. That was all set ahead of time so that you don't have a biased interfering right we wanna make sure that biased cannot change studies as they're going along now. I WanNa make this clear because I'm sure someone out there is going to try and say I didn't say this on the other hand is kind of a brand new way to do studies right. This is what we call adaptive. This study we don't want to be locked in on. You know what we determined up front. We don't WANNA get into trouble at Dr William Thompson got into but to be clear and to study is really just designed to if you see that the drug is having so much success then maybe you want WanNa just bail out of having some sailing control group and start you know moving them into so that they're not wasting their lives and being put a danger. We know it works. Let's move them into the group gets the drug or maybe we WANNA say Geez. We're having such success here. We should test heidrick chloroquine against it. They want to be able to change. What the study can do all right? So it's an adaptive studied but with of that caveat in place for member that you know those would be substantial changes to the study. I want to show you this changes. That have happened to this. Study being run by Dr Anthony Fouled. She'd take a look at this. Oh by the way that we talked about Placebo Group right here. We go the placebo. Now Dr Fau has been known. Be Bragging that this is a really great gold. Standard Placebo Studies. Something that I've been asking for from in vaccines from the moment I stepped in this. Nih clinical trial from desert to treat covert nineteen begins. We urgently need a safe and effective treatment for cove in nineteen although rim desert has been administered to some patients with Kobe. Nineteen we do not have solid dated indicate it can improve clinical outcomes said Nihay director and US Corona virus taskforce member Anthony s bow G. M. D. A. Randomized PLACEBO CONTROLLED TRIAL. The gold standard for determining if an experimental treatment can benefit patients. Read that again because I really wanted to start locking your head around this because I'm going to talk about a lot of the next several months as they tried to avoid this process with a vaccine a randomized placebo controlled. Trial is the gold standard for determining if an experimental treatment can benefit patients by the way no placebo being used right now in the Nih version of the vaccine. That's under trial no placebo group as one point that out. So they're not using the gold standard there but let's stick with Rim desert here. They are or are they. I want you to look at this placebo. Is IT SALINE INJECTION? So the people have no effect whatsoever. No the supply and matching placebo is a layoff. Allies formulation is identical in physical appearance to the active layoff. Allies formulation contains the same inactive. Ingredients the drug resume. Desert is a single Diaz. Or is this got it. Okay so let's go to the non-active ingrains what are they talking about? We're looking at. The drug retinas appear in addition to the active ingredients. That lie off lies. Formulation desert contains the following inactive ingredients. Water soulful beautiful lethal lethal Beta Cyclo dextra sodium SP and hydrochloric acid and or. You chloride all right last. Two words sodium hydroxide. I'm sorry I have no idea where that SB does. But that other one those other two sodium hydrochloride. Can I see it again? Let me read it. Let me read it all right. Hydrochloric acid end or sodium hydroxide. These are things that pretty sure. When I've watched you know episodes of the Sopranos. This is what they feel like a bathtub with to dissolve the people they've cut into pieces. It's an incredible acid right. So here's the point. Why didn't they just give them a saline injection right? I mean you're giving them a known toxic poison in the placebo. Group is really weird. We've talked about this vaccines now. They're doing it in a drug trial. It makes absolutely no sense. You need to be able to say as they did in that really bad hydroxy chloroquine study more. People died that. Got This drug than those. That didn't get anything right. Well here they're going to try and say that well then our placebo group. But you're placebo. Group was giving a toxic chemical and I also wanted you to ask yourself about the legal or moral ramifications of that because by the way the definition of a placebo was supposed to be something that has no effect on the human body snow. We have a pure safety control group. We know that sodium chloride did I get that right. This time you by drug side. Okay wishes we know that sodium hydroxide is not having no effect on your body is definitely having effect on your body and that's in your control group so all these things we've laid out now. Let's look at what happens with this trial so we started out with. We had three hundred ninety four patients right well all of a sudden when we look at March twentieth about a month later all of a sudden they decide to increase the amount of patients on both sides there now changing the amount of people from the one hundred ninety seven to two hundred twenty for a total of four hundred forty people involved in the trial. We have no idea why that would be the case. But it's odd then you look at the placebo you know group and here they're say during the what am I looking at here. Why Oh okay here. We go on April twentieth. We through these studies. We do this together last minute but let me. It's really brilliant. If I can keep it together April twentieth now. Okay sometime later. They increase it again to two hundred eighty six study participants in each side. So now we're up in five hundred over. Five hundred people have been added. But here's what is interesting. This seems to be a problem now. The study is bigger than we ever planned on it being with this group. And so what do they say you know? What if we don't have enough of our fake placebo? That's got that toxic chemical in it then and only then you may have to use an alternative? A matching placebo of normal saline of equal volume may be given if there are limitations on placebo supplies. I mean. Isn't that outrageous? I mean why are we using sailing from the beginning and now that the study from whatever reasons bloating getting bigger and bigger? Now we're saying Oh you know what on those last if we run out of it go ahead to sailly really really strange stuff here. You are clearly manipulating your control group by giving them poison and you're obviously trying to do something by growing the group remember even though. This is an adaptive study. They didn't end the control group. They haven't changed the control to another drug because they're seeing so much success. I'm GONNA speculate here. I'm GONNA speculate that. Maybe the effect is so small that it's not statistically significant. They're saying maybe a little bit better outcome from desert but they'll have to stay with statistically insignificant. The only way you'd get around that by adding more people to study adding more people study. I'm just guessing here otherwise it makes no sense. What are you going to see? And five hundred and eighty people that you didn't see in the four one hundred and forty. Well then something really odd changes. They keep growing the numbers by the way it ends up getting to about eight hundred people. This study keeps bloating. But here's what I WANNA point out to you. That was really weird. Remember when there was seven categories we were going to look at well? Guess what happens to those categories in the middle of studying not bringing new new drugs new competitors? They changed the categories. Look at this all of a sudden on April twentieth. They cut the whole seven group of Seven. We're going to look at right now. We're GONNA look at number one. Three hospitalized not require supplemental oxygen to not hospitalize limitation on activities and or requiring home oxygen. And three not hospitalize. No limitations on activities You might say okay. What's the big deal? Well I always say one of the big deals. Is You no longer have a category for death? You no longer going to say one of the major things. We're looking at his death. How is that the case? Isn't that the entire point? We want to know if this drug keeps people from dying and the one category. You removed.

chloroquine Rim desert Nih Dr Anthony Fouled Placebo Group bloating Kobe Bill Gates WanNa Rendez Aviram Desa density Dr William Thompson CNN president Fda Dr Erickson Ram desert Dr Foudy fraud
"remdesivir" Discussed on Second Opinion

Second Opinion

04:51 min | 1 year ago

"remdesivir" Discussed on Second Opinion

"This is Dr Michael Wilks with a second opinion. Vaccines and medications will be the ultimate weapon used to beat Kovic. Nineteen and there's a giant race to develop the first medications vaccine driven both by Prophet and prestige. The potential market is enormous. This week we learned about the limited effectiveness of a drug called rim disappear made by Gilead Sciences but the story of that drugs development is far more interesting than was reported. The story starts with a universally fatal illness in cats called Feline infectious peritonitis or F-. Ip this nasty disease is caused by a corona virus and is surprisingly common in cats. Who spent a lot of time in shelters or rescue facilities? Dr Neal Peterson is a distinguished professor of veterinary medicine at UC Davis and has spent his professional career beginning in one thousand nine hundred sixty four studying corona viruses in animals particularly in the cat. He tried for years to develop a vaccine for F. I. P. Vaccines have never been highly effective against corona viruses. So this is something that the human Researchers Heaven appreciated. They haven't taken seriously so without a vaccine. That left only the option of medication. Dr Peterson worked collaboratively with Gilead Sciences. To look at their existing compounds for chemicals that might help with F. I. B. and we found two drugs that were highly effective against F- IP virus in tissue culture and a second drug was called rim disappear. This is the drug that this week. Dr Vouch e touted as being a benefit to people infected with Kovin we have had our little pandemic. That's been going on for years and we've been treating patients with basically the same drug having high success rate and nobody has even mentioned that it exists. No one paid any attention to the veterinarian who had great experience with Corona Viruses. Gilead refused to allow him de severe to be made for cats because there was very little money in it gilead was waiting for something really big that could result in treatment for humans and generate significant money. They tested the drug as a treatment for Ebola but it failed so they waited. According to Peterson Gilead was afraid if the drug was approved for and it showed some side effects it could prevent future approval for humans and squelched their chance of making hundreds of millions of dollars so rendez severe sat on the shelf and could not be used for cats with F. I. P. But enter the Chinese who also had a growing problem with F. I. P. in their own cats they saw the potential of the drug rendez severe for cats and they began to produce it themselves and interestingly the scented covertly to pet owners here in the United States but then came cove and the Chinese saw the drugs potential for treating corona viruses in humans and perhaps the rest is now history with the recent trials showing it is moderately successful in treating Cova nineteen and Gilead stocks. Shooting up of course one lesson that might go. Unnoticed are the important gems that lurk in the world of animal science. They had evidence from the TAT. But you see nobody ever uses that. Nobody references those papers from the medical side. They all talk about some experimental bow. Study or some primate infection study but they never mentioned the cat. Human medicine is often unaware of what's happening in animal health. As we now rushed to find a vaccine for cove there are also important lessons. We risk missing. You realize that we've been vaccinating krona viruses in cats and in poultry and swine and even some of the other species for decades. We know all the weaknesses and strengths of vaccines. We've studied Corona virus infection and pathogenesis in detail. Do you ever see anything in the literature? Saying hey the poultry. Industry has been vaccinating for infections bronchitis for decades. They never mentioned any of that stuff. Perhaps this speaks to the enormous importance of the concept of one health. That is the interdependence of all living things. This is Dr Michael Wilks with a second opinion..

Dr Neal Peterson Gilead Sciences Dr Michael Wilks Dr Vouch e Kovic Ebola distinguished professor UC Davis United States Cova
"remdesivir" Discussed on The Last Word with Lawrence O'Donnell

The Last Word with Lawrence O'Donnell

09:03 min | 1 year ago

"remdesivir" Discussed on The Last Word with Lawrence O'Donnell

"Now it's time for a special hour here on. Msnbc it's life in the time of Corona Virus hosted by Dr Zeke Emanuel and the Great L. E. Val shady thing Ellie. Thank you my friend. Good to see you and we'll see you again on Monday. How many people are sick with the virus in the United States? And when did they get sick answering? These questions are crucial but they have never been answered well and it seems that the federal government dramatically misunderstood what was happening in America as the corona virus outbreak began on the last day of February the CDC reported that Americans had tested positive for covert nineteen. Today the report number is more than a million and at least some of the death and economic damage sweeping the United States could have been avoided if we had only started testing for the virus earlier but even as more states prepare to open backup for business. We're far from the end of this scourge and the mid crisis lesson to learn. Is that our past failures. Do not need to dictate our future. Actions as global health official and former head of the World Bank. Jim Yong Kim wrote in the New Yorker last week. It's not too late to go on. The offense against the corona virus and there are promising signs that are nascent offensive. Efforts are working but will only succeed. If we're guided by one thing and that one thing is data there is no other way to defeat corona virus. All of our decisions must be based on the evidence available to us not on the basis of political advantage on the basis of misdirected protests. We can only succeed if we follow the science and that much is going to be our focus in the hour ahead tonight in a week with so many medical and science headlines to keep track of I am once again grateful to be joined by Dr Zeke Emanuel for the Hour Dr Emmanuel is an NBC News and Msnbc Senior Medical Contributor. It's GonNa give us much needed reality check on. The News of treatment breakthroughs and vaccine development also had major new concerns about testing labs that are sitting idle antibody tests that are widely wildly inaccurate and unregulated. We're GonNa talk about what's broken and more importantly how to fix it. Also Miami Mayor Francis Suarez himself a Kobe nineteen survivor. There's going to be here in a few minutes. Mayor Suarez is at the heart of the reopening debate in the country. While Florida is opening some aspects of its economy. The Population Center of Miami Dade County is staying shut. It is a difficult state versus city. Dichotomy that is playing out across this nation and that is so difficult because thirty million Americans. And that's most likely. An undercount are out of work desperate for their next paycheck tonight. We're going to examine the push to open up to get back to work versus the concerns of triggering a second wave of corona virus. If we open up before the science before the data tells it it is safe to do. So let's begin with the numbers. The United States now has one point one million reported cases of Corona virus. The United States has sixty four thousand nine hundred and fifty reported deaths from the corona virus. The FDA has issued emergency youth author- authorization for Gilead Sciences. Antiviral Drug Rendez Aveer for patients hospitalized with a severe case of cove nineteen the. Fda's not came after. Dr Anthony Fauci. The Nation's top infectious disease experts said the trial data showed that the drug had a clear cut significant positive effect in diminishing the time to recovery. Now we should note. This does not mean the drug should be used for all hospitalized. Patients previous research suggested the drug may have potentially dangerous side effects in some patients but the maker of Ramez Rendez Aveer Gilead. Sciences is hoping that they can expand. The drugs used for patents for patients earlier in the course of their illness. Here's the CEO Gilead Sciences. On the today show we were prepared and ready for this virus Because of some of the work we've done with this year for the past decade and at that. Same time that we put remm disappear into clinical trials. We also made the decision before knowing it was going to be effective to expand our capacity knowing the global crisis was and knowing we would have to be ready in the event that this turned out to be effective for patients so we have gone from around five thousand treatment courses to today almost one hundred thousand courses and because of our investments early. We think we will get to millions of treatment courses by the end of the year. Meanwhile America is starting to reopen more than half. The Nation's governors are relaxing pandemic restrictions in their states while hoping that the novel Corona Virus doesn't Spike setting off another round of closures. But there is good reason for that caution. A new report from the University of Minnesota suggests that the corona virus pandemic could stretch for two more years with recurring spikes until roughly two thirds or more of the population has developed immunity. And we have two pieces of news tonight from the White House. News is reporting that the White House has whittled the field of possible vaccines in its Operation Warp Speed Program from ninety three to fourteen which will undergo more testing in the next couple of weeks and breaking tonight. The White House is blocking Dr Faucher from tested for testifying before a House subcommittee that is investigating the corona virus outbreak. In response. The White House said it would be counterproductive to take away from his work but while he's been blocked from testifying before the House and B. C. News also learned late tonight that a spokesperson for the Senate Health Committee says that Dr Vouch will testify before that committee on May the twelve. Okay that's the catch up on where we are in the news. I want to bring in Zeke Emanuel. He is a physician who served as a health policy advisor in the Obama Administration. He's not now the vice provost for Global Initiatives at the University of Pennsylvania. Zeke great to see you as always as always we're loaded with questions for you and the first one starts with Rendez Aveer. What's the situation with the struck? So let's first talk about how relatives aveer works. The virus remember comes into the cell into a long cell and then gets ingested and has to reproduce and make a lot more viruses run disappear blocks that because it incorporates into the genetic code of the virus and break basically breaks it up and that stops it from reproducing. So what are these test results? That doctor was talking about basically. They started in the first of February and they've gone on for three months with over a thousand patients involved in the United States Europe and Asia The results were relatively sick. Patients does needing oxygenation or being on a ventilator and they left the hospital sooner after eleven days patients who got the placebo left after fifteen days when you looked at mortality while proportion of patients died in each Eight percent of patients died. Who received from disappear and about eleven point? Six percent die who received placebo. But that wasn't what we call statistically significant it didn't mean that it was enough. It could have happened by chance. So that was the result that led the FDA to say there's enough information here Probably the benefits are better than the risk. And we're going to give us an emergency approval. Dr Chee among others said that this was an encouraging step. It's clearly not a home. Run for anyone. Let me just say a couple of words and caution? This is good but not great. We're probably going to need multiple drugs to treat this virus again. We might have to move from disappear up earlier and the last thing I want to say is now that we've approved the drug. It's going to be hard to do a placebo controlled trial. So we're going to have to test all new drugs against run VIZ aveer and that makes it harder and will require more patients in any trial for this trial. We needed three months. That gives you a sense for how long these next trials of new therapeutics are going to be right and then to district. We talked about a little bit last week that it is much harder than you think. When we're trying these new drugs if you want to try and get a result out of that statistically significant you actually need a whole lot of people in the drug in the trial so there's there's complexity in developing therapeutics and vaccines thanks seek. Let's let's continue this discussion. With Miami. Mayor Francis Suarez March. Mayor Suarez was quarantined for eighteen days after testing positive for rotavirus himself. He as he's joining us now mayor. It's good to see you. How's your health? First of all thank.

Dr Zeke Emanuel United States Francis Suarez FDA corona White House Miami Ramez Rendez Aveer Gilead America Mayor Francis Suarez Dr Anthony Fauci Rendez Aveer Gilead Sciences Jim Yong Kim CEO Gilead Sciences Florida Population Center of Miami Dad CDC rotavirus Hour Dr Emmanuel
"remdesivir" Discussed on Coronacast

Coronacast

10:04 min | 1 year ago

"remdesivir" Discussed on Coronacast

"It's Friday the first of May God. It's May already know that it was Jackie. Remember what happened three days ago and this is only been going since End of December. It's extraordinary so we're inching closer to different Q. Is coming through a drug. That was originally developed. Ibala looks like it might be useful in trading nineteen but Norman. Give us the lowdown. How excited should we be getting about rim desert on a scale of one to ten four would be my be my skill here just a bit of background room disappear is an attempt by a pharmaceutical company called? Gilead had to create what's called a broad spectrum antiviral. This is the holy grail in antiviral drugs. When I was training and Mitch and there were no anti viral drugs. The antiviral drugs have been developed over. The years tend to be very specific to specific viruses and the ones that are broader spectrum tend to have quite a lot of side effects not very effective so desert veer showed some help Ebola. That's not so certain. They were hoping in marriage. The Middle Easterners Perjury virus. That might help that. Still not so certain but they were trying out here and in the lab at seemed to have a good effect on the covered nineteen virus. So they've been doing trials all over the place so the trial that was referred to by. Tony who is on the President United States Advisory Group? And he's also head of the National Institute of Allergy and Infectious. Diseases was actually a government. Funded Study National Institute of Allergy New Study about a thousand people in multiple centers. And what they showed in this trial and it's not been published yet and it's not been pure reviewed so as a way to go yet. This is a drug that's given intravenously to people in hospital. So it's not a tablet you can get your general practitioners office and what they showed. Was that the time to recovery was short-term so from an average of fifteen days to eleven days. Everybody responded for memories about fifty percent of people responded to this but they got a four day reduction in hospital which is not bad but not a huge game changer and it also showed maybe that it reduced the chances of dying. It would seem to make sense that it was reducing the recovery time that people will have less less chance of dying but that's not absolutely clear from the study and it may well be that they just didn't have enough people on this study to find out. How many people did they have in the study about? A thousand in the National Institute study. So that's a problem in these studies where you've just got to get enough people in a well designed randomized trial to get the answers you want and it may well be that even a study. That sounds big. Thousand isn't big enough to really show up. Or Difference in mortality rates. And that's at the same time or just after the Lancet published a controversial paper from China which was also trial over Endesa Vir which showed no effect. This is one way or the whol released the results accidentally they say last week. You really can't see anything about this Chinese trial. It was not well designed. People were getting all sorts of drugs and this was at a time when China was throwing the Kitchen. Sink people to try and see what might work you can. You can't blame them for that but it really corrupted the results of the trial. I'm not saying it was a corrupt trial. Just fate to the results of the trial. Not Enough people in the trial. I think that they were coming off the peak of their epidemic. And therefore there weren't enough people around to recruit to do the study and so you can't really hang your hat on anything on the on the Chinese study. But as twenty-five she said in the Oval Office this is the first sign that you can actually get a drug that helps and be glad of that and it means that you can only build on that for the future. So you mentioned that. Antivirus have side effects. Do we know what the side effects are for Rendez Aveer. That's the criticism of the release of these results. Preliminary results suggest. It doesn't have very many but people have said that before about drugs. And when you've done these randomized child's decided rates have come out. I think that's why you have to wait for the results of this trial to report it. Remember that you really only giving it to a very select group of people who are seriously ill in hospital in an interview this environment so there are already very sick. You and the net effect was benefit and so they got out of hospital earlier and probably fewer people died yet to be proven so suggests that it's not not making people worse in a fairly Dr Situation but to be more information to be gathered reviewed and even if they can replicate these results in other studies. Certainly not a magic bullet. It's it's reducing the risk of severe disease in people who already really seek which is great news for the means that Thir- maybe a principal here and how they've designed the drug where you could design it better and becomes better targeted. You find out why it's working and then you can more. Finally Target Future Drugs. He might be able to get a broad spectrum anti viral load of this but you might get an antique covered nineteen antivirals out of it eventually so in Australia. Lucky that we've got such low numbers at the moment. Is it relevant to our people here? Who was secret the moment you're still people dying. Unfortunately industry was the start breaking the residential care facility in New South Wales. This is given to people who are in hospital deteriorating low oxygen. Because if they're GONNA DO BADLY. Those are the people who get this and hopefully be diverted to a better course and hopefully you're a die and they would certainly use fewer resources if there's a big if results of this trial replicated in real life. Can we get really not for a second? Do we know what it is? What these sorts of drugs I doing inside the body that stops disease from getting too bad we know what room desert does. So what Rim desert does is that the form of genetic material that's in this virus is are in a desert so it's really while spectrum. It's really designed for our Rene viruses like Ebola and corona virus. And what it does. Is it interprets itself into the RN? As so that when the viruses replicating it doesn't replicate well because there's a big error there in the irony. You've really just stuffed up the Rene and therefore the virus fails to replicate right disrupts the code and then you can't progress. After that stops a.

Rim desert Diseases Study National Institute of Al China National Institute of Allergy Jackie Ibala Perjury Norman Gilead Ebola Mitch National Institute Rene Rendez Aveer Oval Office Tony Endesa Vir
"remdesivir" Discussed on Squawk Pod

Squawk Pod

07:45 min | 1 year ago

"remdesivir" Discussed on Squawk Pod

"Think in the same direction. Well you get more clarity when delayed releases results from its own trials. That's certainly true. There's there's three studies underway There's the NASD study. That trial met its primary endpoint. There's GonNa be more later today. from I think I believe Dr Fao she at a press conference there is also and I'm getting this right now. there's also Data that's going to come out from the Open Label Studies. They kill you. It's been conducting non randomized studies. But I think maybe we have more news on on this meg view. You have a different study or just more analysis of this one joe have exactly what Dr Godly was just referring to you and I assume he was just reading the press releases. I was just reading because Gilead just put out. Its own study results so that was the one we were expecting today. This is in severe patients with cove. Nineteen and as we mentioned it was an open label study and it was not placebo controlled so the data are difficult to draw obvious conclusions from the top line. Is that the five day and ten day dosing. Regimens appeared similar in this study. And Gillian says it's a compliment to the study. Met Its primary goal and that one was placebo controlled so the NIH results are the ones that are going to really tell us how well this drug worked. But what Gilead is saying here. Is that those two dosing. Groups regiments did appear similar. So that could increase the supply of the drug. They're also saying in the release here that earlier treatment did appear to be better for patients they say patients who received from desert within ten days of symptom onset had improved outcomes compared with those who received after ten days. They say pooling data across the treatment arms by day. Fourteen sixty two percent of patients treated early. We're able to be discharged from the hospital. Compared with forty nine percent of patients who were treated late of course because this is not bliss evoke controlled. We don't know those patients would have just gotten better by themselves. And if the impact of earlier treatment could have been influenced by other things. So that's why the results are going to be so critical to hear later today. Guys one one added piece here and I'm getting this right now so Coming across to me but I think that there's going to be a press conference later today with Tony. Fao going to talk about the NASD results. So it's possible that if that trial really does show a trend towards Positive outcome here Fda could authorizes under an emergency use authorization or under an accelerated approval fairly quickly But I would expect them to have a press conference so to provide more information later. Today you had said earlier. The good news is the five day treatment is just as effective as the ten day treatment that that means twice as much of this drug to go around but Meg d you or Dr Gotlib. Either of you know what kind of supplies we have for. Severe what kind of numbers. You could be seeing how quickly things could ramp up in order to get more of the drug made. Yes so Gillian has put out. What the supply it expects to be able to make is by. May they expect to be able to supply one hundred forty thousand doses of the medicine? But that's at the ten day regimen so if they can cut that to a five day regimen for a lot of patients that will significantly increase that supply. That's not a huge amount of drug. The company is looking at reformulating it into potentially oil deliverable drugs so into pill or into an inhalable drug. But that's not a slow process. I'm sure Dr Gotlib. We'll have more insight on that and on the potential supply and ways to increase that quickly than I would. So how long would that is that difficult to do? An oral formulation Dr Oil formulation would be difficult here because of the complexities in manufacturing this product. I think that there is some speculation that you can develop a nebulizer and inhaled formulations of this drug. That could potentially be efficacious as well but right now the issue is just GonNa be ramping supply. Gilliat it's been working with a lot of contract manufacturing organizations to try to increase supply but it's long manufacturing process at the complex drug manufacturers. So we are going to be supply constrained. I do think you're going to see more information coming very shortly from federal agencies and from the company talking about these results today and then talking about the process going forward and how this could be made available more broadly either under accelerated approval or more likely under an emergency use authorization which would allow commercial distribution of drug to make make sure more people can get access to it in a setting of the current epidemic. Scott where where is manufactured Menu I don't know for sure is the answer but it's manufactured at multiple contract manufacturers right now. I know that the company has been working with a lot of different manufacturers. And so it's not a single location where it's being it's all being manufactured says here and it's really about supply that it is increasing capacity with partners. North America Europe and Asia. And I think that probably gets to your question about the importance of where things are made to be able to supply. Kits will you had that op Ed in the Wall Street Journal or this week raising concerns about even if a cure or vaccine is developed at not having it manufactured here might mean that Americans. Don't get it I yeah. I don't think that the entire manufacturing processes totally within the United States right now they might be components of of of it or there might be some supply that you can do totally within the US. But I think aspects of the supply chain for this drug. Come from other parts of the world to your point becky. So you know that's why it. Gilead has worked globally to try to make this drug available particularly in China where I think. Some of the supply chain originates but The company's been working in the United States government. I think has been working to try to domesticate. More than manufacturing increase supply here. It's a complex drug to manufacture So you know. In some ways it's not an optimized drug it's can't be formulated into an oral agent very easily complex to manufacture it needs to be delivered intravenously. It does have side effects associated with it. So it's not a perfect drug what it is. It's a drug that was on the shelf. It's the first generation at the viral against Corona virus that can be effective for a certain number of patients. This is not a home run. I'm a cure by any means but I think that this can be very effective in the context of better treatment for patients a better understanding of how to treat these patients and hopefully other drugs. They're gonNA come onto the market in the fall. This is part of the better toolbox. We've been talking about better testing better treatments Dr. Do we talk about the time line with you? All the time. And the ability to try to give confidence to Americans and frankly those all over the world to go back go back to work to go back to some sense of normalcy and we've talked about a possible vaccine bringing that kind of sense normalcy. How does this change the dynamic? Meaning do you think that this drug based on what you know will create the kind of confidence and win. That people would say themselves. You know what? I'm maybe I'm willing to go out. Go Out and do what I'm GonNa do and if I get this. I'll have the confidence to know that I can take this drug and things might be okay. Is that yeah? We'll come into place. I'm in the same place I've been when we've had this discussion many times. Which is this drug. Coupled with the therapeutic. Antibodies ARE UNDER DEVELOPMENT BY REGENERATION VEER BIOTECHNOLOGY. Amgen and lily coupled which with much better testing that we're going to have the ability to millions of people week heading into the fall. I think that that could be a robust toolbox. That could mitigate the risk and help help reduce the fear. That if you get this that that is a race to the bottom that. There's nothing there to help you. We're also learning how to treat patients with covert much more effectively in the hospital learning what interventions to do and not do so. I think all of this is gonNA put us in a much different posture. For the fall. This is a part of that toolbox. We talked about that could reduce the risk of fall and allow us to get back to some semblance of our normal lives even with covert circulating in the background. Dr Gotlib Meg WanNa thank you. All especially Dr Gotlib and meg for getting on so quickly with that breaking.

Dr Gotlib Dr Gotlib Meg Wan Gilead NASD Gillian United States Dr Fao Dr Godly Amgen joe NIH Wall Street Journal Fda Tony North America Asia China Scott
"remdesivir" Discussed on Squawk Pod

Squawk Pod

08:09 min | 1 year ago

"remdesivir" Discussed on Squawk Pod

"For another week or two businesses will be encouraged to contain telework where they can so those are going to be some of the kinds of things that get implemented. The one thing that was carries about the recommendations. I think the states are unlikely to follow is the guidance that would permit gyms to reopen and also indoor venues entertainment venues sporting events. I think states are going to be a little bit more circumspect about those kinds of activities and bring them back after they've brought back workers. Okay Dr Scott Gottlieb. Thank you as always for your insight and perspective. It helps us a lot trying to understand what's going on next on. Swapan the hunt for a cove nineteen vaccine and the unprecedented collaboration between two Global Pharma giants to get out soon Sanofi. Ceo JOINS US. Believe one of the few companies will be able to make vaccine scale. That's right after this from CNBC Drugmakers around the globe are teaming up to fight the novel Corona Virus Pandemic which has infected about two million people worldwide. Just this week. European pharmaceutical giant Sanofi and GlaxoSmithKline announced. They are combining resources to develop Kobe. Nineteen back scene and aimed to produce a batch within the next eighteen months. Sanofi has also committed to donating one hundred million doses of the decades old anti malarial drug hydroxy chloroquine potential but unproven weapon against coca nineteen to fifty countries across the world. President trump has touted the drug as a potential lifesaver and governor. Andrew Cuomo has agreed to provide two thousands of seriously ill patients in New York hospitals in combination with another treatment Zithromax but there are critics of hydroxy chloroquine. Some say the drug could pose potentially lethal risks to those susceptible to heart conditions and Sanofi is also partnering with Startup luminosity six to create a smartphone corona virus test. There really is an APP for almost everything but it has become increasingly clear. That rapid reliable mass testing is one of the key strategies for successful containment of the outbreak. And for what comes after Sanofi. Ceo Paul Hudson joined Joe Kernan. Today on Squawk box to discuss. The company's Corona Virus efforts tells about the vaccine I First off with that was announced a week ago or so I guess it was announced on the fourteenth. So what does it involve? What's a platform in the proof of concept it's been done with other vaccines the method? You're using so good morning. Joe All thanks for having me on. Yeah it's it's a big step firstly. It's a collaboration of two large companies. Bring in the best. I have to find something to try and get back to normal life as soon as possible so we have to his backseat through. Next year. We believe the One of the few companies were one hundred years old survey we believe one of the few companies that will be able to make a vaccine at huge scale. We're talking one hundred four hundred six hundred million doses next year. It just going to be required to get that you know. We also have another shot on goal by the way which is anemone Cutting edge technology upbringing boastful. The only competitive with two vaccines two shots on go come with delight to be bringing them forward and and trying to do something. Tell patients next year by the coastal testing is also something that that everyone thinks in lieu of the eighteen months that you're talking about for a vaccine. If if you knew or that you already had it if you knew who did. And who didn't who was susceptible so there's a startup called luminol sticks so that what what your envisioning is a way for people not to go anywhere near the healthcare worker or a hospital setting or but completely able to do something at home self administer the test and then you go go into how that will work. And you get the results on your. There's an APP on your smartphone. How does it exactly? What do you envision? Paul limits is getting to normal next year restarting is going to be about vaccines about people whether they have the virus so not and you know we did. The collaboration on the vaccine three weeks for too long and then at the other end of the scale we partner with a small startup in in less than fourteen days. And we did it. Because it's quite clear that people need to people want to know where they stand at. Did they have it or not and they will. They will not always get the opportunity to get health costanza. Maybe they don't even want it so I'm using some cutting edge technology at plugging it into And using a saliva sample. You should be able to get a result in about thirty minutes. We to bring this forward by the end of this year. You think you know again will one of the few companies working diagnostics vaccines and indeed treatments at the Kevin Nineteen. I think the phone from we thought we needed to bring expertise in and in. The area is to convene a bitch interesting to be able to do that. Can you talk about a couple of therapeutics in one one obviously somewhat controversial donate hydroxy? Clark one hundred million doses and. That's not the only one that you're working on an interesting that so many anti or immune related therapeutics like anti Rheumatoid arthritis strikes might have some some benefit here because of the Whatever it is that corona virus does in the lungs in terms of cytokine storms etc. So you have A. You're partnering with regeneration. What are the prospects for cavs Zara? And what do you think of hydroxy chloroquine and its its benefits. Will you know we started looking at these medicines? Because of early anecdotal feedback from China Many different approaches for tested is medicines root for different illnesses. And we wanted to have no regrets. You know. If it'd been used experimentally. We wanted to step forward. Do the clinical trials do speed and provide the medicines. It seemed like something we've just simply had to do as a company and you know and that's what we've done just a week or two away from whether whether they are effective and cancels the disease at the patients. I don't think there's anything controversial. I think what really matters is to do the pinnacle studying finance and we couldn't wait because if we waited at before letting people know we provide them. It was just unnecessary. So we come to the front would make in the drugs. Available will do the studies if they demonstrate the effect. Then we'll bring them for patients across the world. It's not the controversy is not necessarily engendered by by the people working on the drugs Paul. That's for sure I won't. I won't point any fingers but we certainly do have some controversy associated with just about everything we do in today's world. We appreciate your time this morning and your efforts Paul Hudson. Ceo Santa Fan and came out. And I just can't my smartphones going to be able to do everything even you know. Test me for corona virus events but good luck with everything and and bring us back up come back and update us on some of this. Thanks Paul and that squad pod for today and for another week. Thank you for listening. And sticking with us as we worked from our couches to bring you interviews recorded on the phone on skype on Zoom. Who knows what will think of next squawk boxes hosted by Joe Kernan Becky Creek and Andrew. Ross sorkin there every morning at six. Am They can't go anywhere else. At least not yet. I wasn't that happy. The gyms are going to reopen right away. I've been enjoying not doing that when I got married dating. Stop exercising right. You're on TV everyday. Yeah look out to get this modest takes and analysis for our TV show right into your ears. Subscribe to Squawk hot. Where everyday your podcasts? We'll meet you back here on Monday. Have a good weekend and stay well..

Sanofi Ceo Paul Hudson chloroquine Ceo Dr Scott Gottlieb CNBC Andrew Cuomo US Kevin Nineteen Joe All Joe Kernan Becky Creek cavs Paul Hudson President Joe Kernan trump New York GlaxoSmithKline partner
"remdesivir" Discussed on Squawk Pod

Squawk Pod

11:40 min | 1 year ago

"remdesivir" Discussed on Squawk Pod

"Give safe and effective. It could become the first approved treatment against Kovic. One thousand nine hundred. The reporter who broke the story spoke to CNBC last night. I did interview a patient who participated in the study. He he lives in Chicago He. He was short at all the classic symptoms of Nineteen that you have heard about. He had to go to the hospital and when he told me. And this is just a single patient experience but what he told me was that essentially he started feeling better like a day after getting the best of your and he was in hospital for four days. You got four days worth of treatment with severe and he was discharged joining us right now to talk more about this and everything else since we talked to him so often. Dr Scott Colleague. He's of course the former FDA Commissioner CNBC contributor served on the board of Pfizer and alumina. Good morning to you. The market is rocketing on this news. As is of course Gilead stock itself. Gilead did put a statement out saying that this is only anecdotal evidence and we need to wait for the final reports and studies to be complete but Weigh in on what we should be taking away from this news and again I. I just mentioned why the important 'cause we also had conflicting news out of China where it appeared. They had stopped their studies and so a lot of the investment community and I think the business world was trying to understand. What's really happening here? But China stopped the studies. Because they couldn't fully enroll them because they stopped accruing cases in China because they're Had subsided so we're not going to get a chance to look at that China data but the Chinese doctors were trying to us from desert here so they did have some indication that the drug was promising that they wouldn't have been trying to reach for it against all the other drugs that were available to them on an experimental basis. This is one of growing number of data sets that suggests that reservoir is inactive drug. It's not a slam dunk. Data said there were two deaths in one hundred and twenty five patients that were enrolled in this this portion of the study this one arm of a of a larger study but most of these patients had severe disease so they were at higher risk of death and a lot of the patients did recover. According to the report that Adam I knew he was able to get from from that institution but it looks like the Drugs Act. We saw that many times on this. Show my hunch is that it's going to work earlier in the disease. Ovitz introduced early in disease. It can be an effective drug. It's not a slam dunk by any means. I don't think it's a cure for the virus but I think when used early in the disease. It's a good antiviral and a good first generation the viral against covert nineteen and as part of a broader therapeutic medicine cabinet. If you will that we might have available by the fall. Coupling this maybe with one of the therapy again by this development that could form a pretty robust treatment set against covert nineteen. Doctor let me understand. This is something you have to. You have to. You have to take it a hospital. That's going to actually be injected into you And when you say get added early. Currently it appears that most of the people were taking it already Either on oxygen or ventilators. Is this something that people could take even earlier than that that's right. I think that drug like this if if it works if it's active against the disease it's probably most effective when used earlier in the course of disease so the way this might fit in is when patients have covered nineteen and get. I admitted to the hospital. If they have risk factors that would predict that. They're going to be more likely to have a bad outcome. They might be dosed with this right when they get admitted. That's typically where you'd see a drug like this which blocks viral replication. Be Most effective. You want to get it in early before you have a lot of virus onboard. Sometimes once you have a lot of virus on board once the virus has been able to replicate in your body and you have a high level and it's created a lot of inflammation simply arresting viral replication at that point and reducing your viral load as. It will doesn't have his strong therapeutic effects. He wanted doses kinds of drugs earlier. That's how we use for example. Tammy flow the drug against flu. You WanNa get that dose early. You WanNa take a right when you first have symptoms to have the maximum benefit. I think that's likely to be how they use this drug. There's other studies underway with this drug looking at milder patients so looking at introducing it earlier in the course of disease. I think that's where we're likely to see the most robust treatment effect. We need to remember if this drug does work and suggestions that it is active against a disease and we do. We do understand that safety profile. Pretty well it was putting a lot of patients with the bowl as well. So there's a big safety database with this drug but if it does work. I don't think this is a cure. I don't think this is GonNa be the one one drug answer to this disease but it can change the contours of the disease and mitigate the worst outcomes for some patients Scott as you point out it might be in combination with a with a monoclonal antibody drug. Just like with the Bola but my point about one was used with with. Evola is and then I think the antibody drug worked better after that so it was Kinda supplanted by that but there is definitely efficacy for versus Evola and we have safety profiles based on so that. We don't really need to go through that. But you've never really pooh-poohed it should and rightly so because the mechanism is so understandable. I mean it should work. Because it's it's an analog of one of the base pairs that and it disrupts the preliminary the ornate dependent darning plumer. It should work and I don't know why people weren't more positive all along about rendez severe when I wrote about five drugs. Two weeks ago I wrote a Wall Street Journal about the five drugs I thought had the most promise for being available in the fall and having a robust and of treatment effect that they can actually change the risk profile for this disease and the five drugs that I called out was severe. In in the fourth therapeutic antibodies early in development by Amgen Veer Biotechnology Lillian regenerate and. I think one of those. Antibodies can be available by the fall. And you couple that with severe which might be a weekly active antiviral. That's effective particularly early in disease. That's a pretty robust therapeutic armor metareum that can change the contours of the risk profile for this disease. So I think people are always thinking that could pull through here. We do have a big safety database from a bowl remember. It wasn't effective against or if it wasn't effective enough to show benefit against the other drugs that it was competing against for master protocol in two thousand fourteen one of which was therapeut- again by by regeneration the same strategy regenerates now using against corona virus. How quickly could let's say you pull out all the stops? You can't do this off label even right now right so he needs. How quickly could you actually get this prescribable for people in authority a lot of tests and just say well? They're all part of a test. So there's a there's a broader data set available right now that probably going to be made public within days. Certainly within a couple of weeks I think that's going to include upwards of four hundred patients that data combined with the Compassionate use data that was published a week ago and the fact that they fully enrolled now very rigorous study being conducted by the nationalist health. I think that's enough data if it continues to trend positively to authorize drug under an emergency use authorization so you could see the drug made available under an e away by the Food and Drug Administration you know within a month if that data set continues to show good top line results that the drugs having a treatment effect because we understand the safety profile fairly well and now that that. Nih studies fully enrolled. The Food and Drug Administration is going to know that going to have a definitive answer on this one way or another because that's a very rigorous studies. You might not wait for the results that study. Knowing that studies fully enrolled in it will read out Mike give regulators enough confidence to make this drug available under any way. Dr a question that I keep seeing online differ doctors and reports talking about it. And I'm curious where you land this idea that there could be long term damage to your lungs and other parts of your body as a result of of this of this virus even if you make it through to the other side can you speak to that. How how does that work is their long term damages that just about the severity of of how much the virus takes over your body impart. I mean part of what you're seeing literature now is this equality of prolonged hospitalization or prolonged bout of critical care. But there's also a lot of things we're learning about. This virus virus is nasty nasty bug. It's a nasty pathogen. It's causing thromboembolic events. It appears we causing thrown events in patients that would previously on unrecognized so it could be the case that a lot of the rapid compensation that we were seeing patients. Would it'd be doing okay and then suddenly de compensate and require intimation in the hospital might have might have been from pulmonary. Embolism blood clots to the lung. We weren't we weren't generally looking for light clots early on because the protocols were to limit contact with patients so you reduce the risk of spread within hospitals. Say they weren't routinely doing echocardiogram of the heart or pulmonary. Embolism studies now that they are starting to do those things. They're finding that a lot of these patients have blood clots. And that's causing that the compensation and now more of these patients being antiquated in the hospital being given blood thinners. So there's a lot we're learning about this virus and things that it does. That's atypical for virus causing long-term sequentially and downward spiral for a lot of patients. Dr Gotlib you've heard the president's plans and and the idea that some states could be allowed to open up as early as today we are not opening all at once but one careful step at a time and some states will be able to open up sooner than others. Some states are not in the kind of trouble that others are in now that we have passed the peak in new cases. We're starting our life again. Obviously some of these governors in different regions are working together to try and make sure that they don't have different rules. Let's say between New York New Jersey and Connecticut. But how concerned would you be about some places opening up today? Are there states? That really is safe enough for that to happen and Windy. When do you think we'll we'll feel a little better about this or alternatively see a second wave well it's not a binary event I mean? I think you could start to see some states that haven't been affected that a more rural states and naturally social distance star to resume some activity for example. Some states have banned long care services and outdoor types of services. They might bring that back those a low risk and you might start to bring those back now. The wearing thing some certain construction activity might bring back. Some states already have allowed. That might stay home state of Connecticut. There's still that kind of activity going on even though we've curtailed a lot of other business activities so you could start to see some activity slowly. Come back to the states. That weren't affected. I think by and large the very effected states particularly in the Tri State area. Going to be looking to start resuming business activity probably mid mid. May which is what we've been saying all along. I think they're going to remain on that timetable. Because you want to see a sustained reduction in cases in wait one or two weeks after that we recommend two weeks and that puts you in mid-may but you're gonna see variability across the country and when people would stage do start to bring back activity. It's going to be a very gradual process. We bring back certain activity. Wait a week or two to see. If there's an upswing in cases based on your testing and your syndrome surveillance data from visits to emergency rooms and other things like that and then you might bring back additional activity and as we bring back activity going to put in place. Certain restrictions on what businesses can do to try to reduce social context? You'll have mandates like you have to check patients as at workers as they come in. Fever checks questionnaires. You can only bring back. Certain compliments of employees. You can't bring back everyone at once. People who are over a certain age or have risk factors might be encouraged to stay at home.

Food and Drug Administration China Dr Scott Colleague Chicago CNBC Connecticut Kovic Pfizer reporter Adam Wall Street Journal Commissioner Nih Amgen Veer Biotechnology Lilli Ovitz Evola Fever Embolism