35 Burst results for "Principal Investigator"
WTOP
"principal investigator" Discussed on WTOP
"$25 a month months with no annual contract plus upgrade to gig and save 20 a month over verizon go to xfinity dot com slash 10g call 1 -800 -XFINITY or visit a store today requires paperless bill in an auto -pay with stored bank account restrictions apply equipment taxes and fees extra after promo regular supply to internet service actual speeds very not guaranteed covers xfinity gig to verizon gig here's abby emery the senior machine learning engineer and principal investigator at noblis on the discussion tackling government challenges through science and technology sponsored by noblis we're seeing huge improvements in terms of machine learning architectures that are used to accomplish incredible performance and also the amount of scale that's available such as data and computational power these two things put together have really set the stage for a renaissance listen to the entire fashion on federal news network dot com search noblis tackling national challenges that continue to rise and change it rapidly can be difficult noblis can help noblis brings together the best of science technology and engineering to solve complex challenges like improving transportation and infrastructure systems countering threats from weapons of mass destruction and enhancing the operability of naval surface ships for twenty five years noblis has been an innovator with the federal government investing in advanced r and d enriching lives and making our nation safer noblis for the best of reasons visit noblis .org to learn more when it comes to one dollar small slippy drinks at 7 11 no one's doing it like you you're inventing new flavor combos throwing caution to the wind you're a frozen fizz whiz a pina colada prodigy you mix cherry and blue raspberry like a pro only you know the perfect ratio just when
WTOP
"principal investigator" Discussed on WTOP
"Testing streaming starting monday the company says select subscribers in canada and the uk will be the first to out try gaming on the tvs testing on pcs and max through the netflix website will begin in the next few weeks it's not clear how soon testing will be extended subscribers in the u s the vice president of games for netflix says the testing is the first step in making games playable on every device where members enjoy netflix tvs computers and mobile companies started pushing for employees to return to the office more than two years ago and utlp w business reporter jeff claybaugh says some companies have regrets about how they handled things early on a survey of managers by flex work software company envoy found 80 regret their initial hard push to return saying they would have approached it differently had they known how much pushback they'd get and policy reversals and concessions have left many feeling they have egg on their face as of july fifty nine percent of full employees -time have completely returned to the office twenty nine percent are in hybrid arrangements and are entirely remote sponsored by teeth keepers dot com dominion national offers dental and vision plans for everyone starting at under eight dollars a month at teeth keepers save dot com go to teeth keepers saved dot com and enroll today coming up former president trump in eighteen others have been indicted on criminal charges in georgia will have the details it's five twelve here's abby emory the senior machine learning engineer and principal investigator at noblis on the discussion tackling government challenges through science and technology sponsored by noblis we're seeing huge improvements in terms of machine learning architectures that are used to accomplish incredible performance and also the amount of scale that's available such as data and computational power these two things put together have really set the stage for a renaissance listen to the entire discussion on federal news network dot com tackling national challenges that continue to rise and change rapidly can be difficult noblis can help noblis brings together the best of science technology and engineering to solve like complex improving challenges transportation and infrastructure systems countering threats from weapons of mass destruction and enhancing the operability of naval surface ships for twenty five years noblis has been an innovator with the federal government investing in advanced r and d enriching lives and making our nation safer noblis for the best of reasons visit l i s dot org to learn more do you want to start manage or grow your small business the u s small business administration can help sba wants to see you win they want to see you grow they have been so helpful and so resourceful thanks to the sba my business is thriving today make sure you get in touch with sba and you will definitely be on your way to
WTOP
"principal investigator" Discussed on WTOP
"Church now coming in at 79. All right, Veronica, thanks. It's brought to you by Mervis Diamond Importers. Mervis means diamonds. For the best quality and value, nobody beats Mervis Diamonds. Visit Mervisdiamond .com. Still ahead here on WTOP. A legal way to avoid paying your taxes in Maryland. Sales tax, that is. Bluchert. $6 .52. Here's Abby Emery, the senior machine learning engineer and principal investigator at Noblesse, the discussion on tackling government challenges through science and technology, sponsored by Noblesse. We're seeing huge improvements in terms of machine learning architectures that are used to accomplish incredible performance and also the amount of that's scale available, such as data and computational power. These two things put together have really set the stage for the AI renaissance. Listen to the entire discussion on federalnewsnetwork .com. Search Tackling national challenges that continue to rise and change rapidly can be difficult. Noblesse can help. Noblesse brings together the best of science, technology and engineering to solve complex challenges, like improving transportation infrastructure and systems, countering threats from weapons of mass destruction and enhancing the operability of naval surface ships. For 25 years, Noblesse has been an innovator with the federal government, investing in advanced R &D, enriching lives and making our nation safer. Noblesse, for the best of reasons. Visit Tackling national Hope for the fans. After endless years in the gridiron desert, Washington
WTOP
"principal investigator" Discussed on WTOP
"Canada ever since the law was passed with school about to start for millions of kids who need it the FDA and Justice Department are calling on makers drug to produce more Adderall the ADHD medication has been in short supply for about a year from the Bloomberg newsroom I'm Larry Kofsky on WTOP overseas Asian stocks this morning the Nikkei is down by 667 points Kospi off almost 40 the is Hang Seng down 400 the Shanghai is off almost 30 good morning welcome into WTOP time now is 12 glad you're with us here's Abby Emery the senior machine learning engineer and principal investigator at Noblesse on the discussion tackling government challenges through science and technology sponsored by Noblesse we're seeing huge improvements in terms of machine learning architectures that are used to accomplish incredible performance and also the amount of scale that's available such as data and computational power these two things put together have really set the stage for AI renaissance listen to the entire discussion on federalnewsnetwork .com search Noblesse tackling national challenges that continue to rise and change rapidly can be difficult Noblesse can help Noblesse brings together the best of science technology and engineering to solve complex challenges like improving transportation and infrastructure systems countering threats from weapons of mass destruction and enhancing the operability of naval surface ships for twenty five years Noblesse has been an innovator with the federal government investing in advanced R &D enriching lives and making our nation safer Noblesse for the best reasons of visit Noblesse .org to learn more Good morning glad you're with us I'm the inline welcome in this is WTOP news former president Donald J Trump faces yet another criminal indictments this week federal grand jury looking into election interference returning an indictment charging Mr. Trump with four criminal accounts including conspiracy to defraud the United States. WTOP's Dimitri Sotis talks to Linnick Carol Washington Post
WTOP
"principal investigator" Discussed on WTOP
"87 gradually falling to the 70s overnight now 7 40 money news 10 and 40 past the hour brought to you by PenFed great rates for everyone and Jeff playback consumer inflation slowed to just 3 % in June down from its peak of 9 .1 % a year ago Thursday is national french fry day McDonald's and Wendy's are among change with free fries if ordered through their the Dow finished Wednesday session up 86 the Nasdaq rallied 158 Jeff Clabel WTOP news now 741 on WTOP extremists in the US military which came first extremism or the armed forces on this week's episode of the hunt with UTOP national security correspondent JJ Green doctor Michael Jensen talks about that Jensen is the principal investigator together with the profiles of individual radicalization in the United States project at the University of Maryland start program for the past couple of years my team at the start center have been looking at the nexus of extremism in US military service and we've been particularly interested in what might distinguish individuals with service backgrounds who participate in mass casualty crimes from those who commit less serious forms of either or just property crimes vandalism financial crimes things of that nature and one of the things that we found in looking looking at what distinguishes these two populations from each other is that extremists with military backgrounds who plan to commit large these -scale attacks have a much higher rate of administrative and punitive discharges from the military than the general military population and what we found is that about 25 % of extremists with military backgrounds who plot these mass casualty crimes received that type of discharge from the military which is far higher than the rate of administrative or punitive discharges in the general military population do you get the sense that in these cases the military came first or the extremism came first it's a mix so we've now looked at about 700 cases of individuals with military backgrounds that are radicalized to the point of committing extremist crimes and we've asked this question you know what was their level of radicalization when they joined the military what was level their when they were active in the military and what was their level of radicalization after they left and what we have found is there are individuals that are affiliated with extremist groups and movements that then attempt to join the military to exploit the weapons training and other skills that you see for military service but they actually make up a very small percentage of extremists with military backgrounds. Dr. Michael Jensen is the principal investigator for the profiles of individual radicalization in the United States project at the University of Maryland Start Center. The full conversation at wtop dot com search national security. JJ Green, wtop news. Be with us again next week at this time for another edition of the hunt. Sign up for JJ's national security newsletter inside the skiff at wtop .com slash alerts. We're not quite done talking about the military or extremism because both of those issues are kind of floating around a particular US senator from Alabama who's been holding up some nominations and some confirmations of high level military people in the US senate. We'll get into all that with JJ and Caldwell of the post just ahead on wtop. Hi, I'm rich McKenzie, owner of Metropolitan bath and tile. I had a customer call me recently and ask if I could recommend someone that could do a small repair in her bathroom. A little surprised at the question, I said, Mrs. Shepherd, we've done two other bathrooms for Why you. wouldn't you have us do the repair? She said, Oh my, I didn't think you'd be interested in such a small So it got me thinking, I wonder how many other folks out there wonder the same thing. Well, I'm here tell to you that at Metropolitan bath and tile, we love small jobs. If it's in a bathroom, we're happy to do it. Everything from re -clocking to a whole new bathroom. It doesn't have to be a big job make to us happy. Small jobs are large. Serving our customers with honesty and integrity, that's what makes us happy. So call us at 1 -800 -NEW -BATH or visit us at MetroBath .com. That's .com. MetroBath Bathroom remodeling. It's what we do. It's all we do. Visit our Our new showroom in Manassas, 744.
Bloomberg Radio New York
"principal investigator" Discussed on Bloomberg Radio New York
"Producer and self confessed space geek, Vicki vergale, digs into the science with the leader of NASA's Osiris Rex mission. This is Dante Loretta, regent's Professor of planetary science and cosmochemistry at the university of Arizona. I also have the honor of serving as the principal investigator for NASA's Osiris Rex asteroid sample return mission. I've read that the water in certain asteroids being almost like a gas station in space, right? Like you said, it would allow for hydrogen and oxygen to be broken down. I mean, I imagine you could distill it for even drinking. It really allows you to go much further into space. Do you see that as the next necessary component to get further out into space for human missions? Absolutely. For several reasons, one is you really don't want to launch your fuel off the surface of the earth because that's the most expensive part of your mission is lifting mass from the surface of the earth into earth orbit. Once you're out into the solar system, you actually don't need a lot of energy to move around. It just takes time to get to these distant locations. Aster rank is an organization they rank asteroids in terms of cost efficiency, both how close to earth they are as well as what minerals and precious metals are in there, but they had said that the top ten most cost effective asteroids would produce around $1.5 trillion of material. Can you talk a little bit about what materials are in there? Most asteroids are not hydrated or rich in water like bennu and yugo, which was the target of the Hayabusa two mission from Jackson. Most of them are metals and stony materials. The metals are dominated by your base metals, iron, nickel, cobalt, chrome, chromium. So you could make steel, a lot of steel in space, the basic components for steel making are out there, and that gets you all kinds of structure and capabilities. And then you're right, the platinum group elements, platinum, rhenium, Iridium, osmium, very rare, and precious on the surface of the earth are present in high abundances. What are you hoping to find from the samples when they return? Blues to the origin of life, full stop. We'll leave it at that. Yeah. Well, thank you so much. I really appreciate your time
Bloomberg Radio New York
"principal investigator" Discussed on Bloomberg Radio New York
"A bunch of guys about to turn blue. It's been more than half a century since Apollo 11 landed on the moon in July 1969, and it's still a thrill to hear those grainy tapes across time and space, but there's also a lot of brain power and money going to a whole different kind of space exploration that maybe you haven't heard as much about. It involves sending spacecraft not to planets, but to asteroids and hauling the precious materials inside them back to earth. But first, our supervising producer and self confessed space geek, Vicki vergale, digs into the science with the leader of NASA's Osiris Rex mission. This is Dante Loretta, regent's Professor of planetary science and cosmochemistry at the university of Arizona. I also have the honor of serving as the principal investigator for NASA's Osiris Rex asteroid sample return mission. I've read that the water in certain asteroids being almost like a gas station in space, right? Like you said, it would allow for hydrogen and oxygen to be broken down. I mean, I imagine you could distill it for even drinking. It really allows you to go much further into space. Do you see that as the next necessary component to get further out into space for human missions? Absolutely. For several reasons, one is you really don't want to launch your fuel off the surface of the earth because that's the most expensive part of your mission is lifting mass from the surface of the earth into earth orbit. Once you're out into the solar system, you actually don't need a lot of energy to move around. It just takes time to get to these distant locations. Aster rank is an organization they rank asteroids in terms of cost efficiency, both how close to earth they are as well as what minerals and precious metals are in there. But they had said that the top ten most cost effective asteroids would produce around $1.5 trillion of material. Can you talk a little bit about what materials are in there? Most asteroids are not hydrated or rich in water like bennu and yugo, which was the target of the Hayabusa two mission from Jackson. Most of them are metals and stony materials. The metals are dominated by your base metals, iron, nickel, cobalt, chrome, chromium. So you could make steel, a lot of steel in space, the basic components for steel making are out there, and that gets you all kinds of structure and capabilities. And then you're right, the platinum group elements, platinum, rhenium, Iridium, osmium, very rare and precious on the surface of the earth, are present in high abundances. What are you hoping to find from the samples when they return? Lose to the origin of life, full stop. We'll leave it at that. Yeah. Well, thank you so much. I really appreciate your time, doctor. My
Bloomberg Radio New York
"principal investigator" Discussed on Bloomberg Radio New York
"We copy you down, eagle. Listen, and quality base here, the eagle has landed. Tranquility. We caught the on the ground. You got a bunch of guys about to turn blue. It's been more than half a century since Apollo 11 landed on the moon in July 1969, and it's still a thrill to hear those greeny tapes across time and space. The U.S. and other nations are now working on well publicized programs to put people back on the moon and maybe Mars at some point, but there's also a lot of brainpower and money going to a whole different kind of space exploration that maybe you haven't heard as much about. It involves sending spacecraft not to plan it, but to asteroids and hauling the precious materials inside them back to earth. Later in the show, I talk with Bloomberg reporter Lauren grush all about the fast growing business of space. But first, our supervising producer and self confessed space geek, Vicki vergale, digs into the science with the leader of NASA's Osiris Rex mission. This is Dante Loretta, regent's Professor of planetary science and cosmochemistry at the university of Arizona. I also have the honor of serving as the principal investigator for NASA's Osiris Rex asteroid sample return mission. Can you tell me about the Osiris Rex mission and what you hope to learn from the samples you're getting from the bennu asteroid? Osiris Rex is a mission of planetary exploration in NASA's new frontiers program. So it's been sponsored by the agency in partnership with the Canadian space agency
Bloomberg Radio New York
"principal investigator" Discussed on Bloomberg Radio New York
"A bunch of guys about to turn blue. It's been more than half a century since Apollo 11 landed on the moon in July 1969, and it still a thrill to hear those greeny tapes across time and space, but there's also a lot of brain power and money going to a whole different kind of space exploration that maybe you haven't heard as much about. It involves sending spacecraft not to planets, but to asteroids and hauling the precious materials inside them back to earth. But first, our supervising producer and self confessed space geek Vicki vergale digs into the science with the leader of NASA's Osiris Rex mission. This is Dante Loretta, regent's Professor of planetary science and cosmochemistry at the university of Arizona. I also have the honor of serving as the principal investigator for NASA's Osiris Rex asteroid sample return mission. I've read that the water in certain asteroids being almost like a gas station in space, right? Like you said, it would allow for hydrogen and oxygen to be broken down. I mean, I imagine you could distill it for even drinking. It really allows you to go much further into space. Do you see that as the next necessary component to get further out into space for human missions? Absolutely. For several reasons, one is you really don't want to launch your fuel off the surface of the earth because that's the most expensive part of your mission is lifting mass from the surface of the earth into earth orbit. Once you're out into the solar system, you actually don't need a lot of energy to move around. It just takes time to get to these distant locations. Aster rank is an organization they rank asteroids in terms of cost efficiency, both how close to earth they are as well as what minerals and precious metals are in there, but they had said that the top ten most cost effective asteroids would produce around $1.5 trillion of material. Can you talk a little bit about what materials are in there? Most asteroids are not hydrated or rich in water like bennu and yugo, which was the target of the Hayabusa two mission from Jackson. Most of them are metals and stony materials. The metals are dominated by your base metals, iron, nickel, cobalt, chrome, chromium. So you could make steel, a lot of steel in space, the basic components for steel making are out there, and that gets you all kinds of structure and capabilities. And then you're right, the platinum group elements, platinum, rhenium, Iridium, osmium, very rare and precious on the surface of the earth, are present in high abundances. What are you hoping to find from the samples when they return? Blues to the origin of life, full stop. Yeah. Well, thank you so much. I really appreciate your time, doctor. My pleasure. Okay, we've heard about
Cyber Security Weekly Podcast
"principal investigator" Discussed on Cyber Security Weekly Podcast
"I've got a special guest Would be joined by nevada. Carta guy who is the principal investigator with the ira and i came sick and light in september with the darpa advanced which stands for defense advanced research projects agency darpa and they came second in the final of the dump a subterranean final challenge the. Thank you very much for joining us. Thanks for having me great end. Maybe the introduces to your role. This is sort of advanced robotics. Doing the dryness knows that the analytics maybe talk a story to data itself and so the prices. Because it's a bit of a story we can go in various wise the maybe just introduced introduces to the challenge itself. And maybe the who you are up against because coming second was quite a big deal. Yes i absolutely so bad. Up as you mentioned is the defense at research projects agency. So it's the opera. A defense research agency in the us funded by the us dollar and they have a history of setting fairly formidable challenges in robotics. Fall for the nostrand. The is very early challenges in autonomous driving literally kicked off the whole automobile medical industry and more recently had Other challenges related robotics A couple five by the focus on nuclear disaster. That wasn't robotics. challenge between nineteen hundred fifteen and the latest attritional stat as adopter each other strand for three years from twenty eighteen and the challenge of all sending a fleet of robots to completely unknown underground environments. That you don't have gps. You don't know where you are It's an extremely warm for radiocommunication. So there's no guarantee that you'll be able to connect your bots and the types of environments that they had they were closed into three categories manmade tunnels Like mining tunnels underground urban such subway and sewer systems and varies industry infrastructure on the ground and then the third category was natural. Caves each of these and rodman's have the unique challenges elements in terms of promising -bility and began to send various time self mobile platforms into these spaces. So we had to solve all those challenges and the actual the actual task sound simple enough. It's almost like easter egg hunt So they hide they they they played a number of predefined article ten classes in this this causes And you have one obel to send your robots because you can't send humans in a Only the robots robots can go in and the other caveat is only one human support lobbed to connect to a computer that can potentially communicate with the with the robots. So within this novel. You need to Find these objects. Identify the correct class of object and its classification problem and localization problem. So you know. Kate sent back accurate. Location of this object. Back to the Base station and then the human supposedly verify that senegal for the novel scoring server. If it's correct us core point and and these objects are presentative of what you'd find. In aftermath of niche is offering absolutely incidence. We have The mannequins representing human survivors. You have backpacks you have hard hats you have climbing group have mobile. Phones have Fire extinguishers handrails Pockets of high concentration of carbon dioxide evans. And that's just on the identification of the objects are you using the i and video analytics to automatically detect. That's a person. That's a fine on a device or object of some kind but again. The system is autonomously identifying these tagging them. As what they. I believe today absolutely out of the ten artifacts majority of them are able to be identified. We surely there are feel. feel things. That condu- racially such as the carbon dioxide concentration and then mobile phones they are they emit bluetooth and wi fi but everything else we did use the shouldn't so our perception system that is common to all of the platforms. Louis ended up deploying six agent so we had to flying robots to track robots and to walking robots each of them had very similar perception And they had camera systems that could identify she Or capturing majors but then yes we did. Use a deep learning based A system to to correctly. Identify the objects before they are sent to the human support former of occasion. And i noticed. dr read kindle his Cto in co-founder of which is a spinout commissioner of ad Data sixty one and we have interviewed the ceo of as well so that does the sort of mirage mapping of the area as well sort of as a ballpark figure how many sort of off the shelf or applications you using in all of this and mounted on top of each other or into into wind. Yes absolutely so you mentioned emerson is is is a company that spun out from all lab back in twenty thirteen so Far identified used to be my colleagues before. They spun out in jameson So they also subcontract with our partner in this challenge and so it's a really nice story here's a. b. matured a lot of technologies over the last three years through this challenge so one of them is a wildcat slammed technology. That's capable of doing. Doing mapping mountaineers localization and mapping and emerson happens to be one of all europe the licenses so they actually use the the slam developed an all lab in their hobble map for knocked hannity's available commercially. So if you want the The the same quality of mapping that we used in this challenge you can but just from from from companies like amazon and Via you'll also in the process of spinning company that specializes in wildcat slam and because currently focuses on the area domain and a lot of and These technologies that.
KQED Radio
"principal investigator" Discussed on KQED Radio
"The ground for perseverance is a big part of ingenuity is mission. That's in part because the little helicopters just to test vehicle it's not designed for scientific research. Xanatos thinks that will change in the future. Though drones will become valuable Explorers, a row to craft can fly up to a cliff side wall and take images of a cliff. We can dive into caves. Having that completely ran new perspective is something that we think is going to blow the doors open on exploration of Mars, and it's not just Mars. NASA is working on a giant drone to explore Saturn's moon Titan. The thing is the size of a small car, and if you're wondering how that's going to work Well, Elizabeth turtles, the principal investigator of the tight emission, says it turns out the moon is a perfect place to fly. It's got a thick atmosphere and not a lot of gravity. So physically, it's actually easier to fly on Titan than it is on on Earth Turtle and the rest of her team are closely watching ingenuity is progress. It's a chance for them to learn about flying another worlds. But also, she says, it's cool. It's just really exciting. It would see a vehicle flying on another. Planet. Although ingenuity isn't flying right this second, it's sitting on the surface of Mars, waiting for the perseverance Rover to catch up. But again, it's not a race. Jeff Brumfield NPR news This is NPR news. It's not always a race on the freeways.
The TWIML AI Podcast
Advancing NLP With Project Debater With Noam Slonim
"All right everyone. I'm here with no i'm slonim. Noam is principal. investigator of project. debater at ibm. No i'm welcome the podcast. Hey hello sam. Thank you for having me. I'm really looking forward to digging. Into our conversation. We're going to focus of course on product debater. And what's new everything about that project. But before we dive in deep there. I'd love to have you share a little bit about your background and how you came to work in a so I did my university in angels lhermitte and machine learning lab. This was laid to nineties. More or less. I graduated in two thousand and two and i walked mainly on Information to take methods cluster analysis and related goten and the main data that was considering back then was the textra later and in two thousand thousand and two i moved to princeton new jersey to do my can mean two thousand and seven i joined. Ibm search and i walked on value. Spacek and in two thousand eleven. I suggested to work on project the battle and this is what. I'm doing enough stan. Years also nice. Nice end was debater in existing project at that time. How far along was it. So he has an interesting history because You know we have this tradition in. Ibm lee search of fat grandchild In artificial intelligence so back in the nineties ibm introduced the deep blue that was able to feed the galley kasparov in chess. In two thousand eleven ibm introduced watson that defeated the all time winners of the tv glacier game jeopardy and just a few days after this event and eamon was sent to all the thousands of philly soldiers so ibm across the globe. Asking us what should be the next grand challenge for. ibm
Science Rules! with Bill Nye
Venus Missions: All the Burning Questions NASA Hopes to Answer
"The long the newseum drought is over. Here's planetary society editor. Ray pauleta ray. Welcome back and thank you for this. June ninth article double venus missions all the burning questions nasa hopes to answer no pun intended. I'm sure double it's now triple right. Tell us about this new announcement from the european space agency. Yes so we're actually getting not one not two but three missions to venus which is to be super exciting. The third mission is actually called envision. Yes say just announced. Recently that they're going to be sending their own spacecraft to venus which is just incredible. I mean it's been thirty years since nasa has sent spacecraft venus. The last one. I believe was magellan. So it's kind of wild that everything is just turning up venus. It's about time thirty one years since that. Lots of magellan. It's just absolutely crazy that we had to wait this long. We hope to have the principal. Investigators for both of the nasa missions. On pretty soon maybe we can get the vision Equivalent of a pi as well. There are a lot of questions that we hope. These missions are going to help us to answer. Even if they don't provide full answers you cover a lot of them in this article. One of them we go back to that drought. I mentioned at the top of this segment. Water there's all the speculation about did venus. Was it a much wetter place. Billions of years ago like mars. Is this going to help us with that. Yeah it's really incredible. I mean when you think of something like venus. It's hard to imagine that there is anything ever even just resembling an ocean on the planet right but was actually a good chance that hey there might have been a watery past so i think that with davinci plus the spacecraft is actually going to drop a sphere through venus's atmosphere and measure some of those noble gases that could be there and that seems to be a big clue in finding out whether or not venus ever had an ocean. And
The President's Inbox
"principal investigator" Discussed on The President's Inbox
"I think we should con- sense understanding regardless going on in the lab as gained functions Just briefly explained for me nicklaus. Because i imagine many people listening to our conversation really. Don't understand the role of the echo. Health alliance in how money went from united states government through a third party to the wuhan institute of technology. The some is a nonprofit in new york and his present is two piece of dasher so the money from dr fauci agency did not get direct. Who have you unc. dr dasha. Who is is the principal investigator. I mean he's the guy responsible for executing research on so. He didn't sub contracted the money to dr january. She at the wuhan institute. She is the woman who is known as the bat woman because she has done. Extensive research on bats. And i believe she's the one who demonstrated or her lab demonstrated that bats were the original source of the virus that gave us one correct as and she's made no secret of the fact that she has received money through the echo health alliance. I believe her. Cv list grant. She has received through that channel. Ride metro public record. So do we know what this grant money. Actually funded has that been made public well whilst we made public is an abstract of the ground. Proposals are the foreground proposal is still secrets. And we don't have exactly what she grants do. But if you read the abstract. It's clear that she was genetically in manipur acing viruses that she was swapping spying proteins from our large collection of novel viruses from one virus to another in a way the over certainly could have caused a again function now. Another very important aspect. Wina about a research researches. She didn't publish one paper in two thousand seventeen which again described how she was doing a spike swap. Experience and crazy. These two novas is able to infect human cells so she was right on the pathway to creating something light sauce covy to amazon. Would you would do nicholas why these experiments were being done. I often hear the phrase. I think you may have used in your writing bug getting ahead of nature. Yes the rationale for james experiments which just around the world day. It wasn't just up to she. These animal origin epidemics gain to occur from time to time. And you can. You can get ahead of them and bridge a half if you take the viruses from the animal before they copying pathogens. If you treat them in your lap making this mutation that relationships to create the pathogen the fear then you can predict when when of ours is ready.
Aviation Week's Check 6 Podcast
Giving Autonomous Aircraft a Moral Compass
"Hello and welcome to this week's check six podcast. I'm greg mark aviation executive editor for technology. Today we're going to ask. Will we ever be able to trust an autonomous aircraft. Nasa is working to ensure that we can and joining us to find out. How a my colleague. Guy norris aviation weeks western. Us bureau chief and our special guest. Marc scoop the principal investigator for at nasa strong flight research center in california a lot about tony and artificial intelligence in aviation particularly in the context of urban taxes an unmanned cargo aircraft. Tony and i are not same thing but they are potentially very complimentary using machine learning to train algorithms to automate takeoff and landing autonomously plan optimum flightpaths recognized obstacles and avoid collisions and identify safe. Landing sites along a route has tremendous potential to make aviation safer. But there is a problem. And here i will grossly oversimplify impart to avoid showing my own lack of real knowledge. The software used in today's avionics such as those pilots and digital flight controls is deterministic. That means the same in input always produces the same output and three rigorous analysis on testing. We can prove to the regulators like the faa that our system will always be safe machine. Learning algorithms non deterministic. Same input doesn't always produce the same output because of some change in the environment inner around an aircraft. It might decide to turn left. not right. And because we fully understand what goes on inside a machine learning algorithm. No amount of testing can guarantee to the regulated. The system will always behave safely. So how do we safely unlock all those great capabilities. That me and i promise.
NEWS 88.7 Programming
About 2000 Texas A&M Students Join COVID-19 Study
"Study to see how the cove in 19 vaccine impacts transmission of the virus. Researchers will compare to groups half that will get the cove in 19 vaccine right away. Well, the rest will delay for a few months. All the reporters Sarah will Ernst talks to principal investigator Rebecca Fisher about what this study could mean for young people across the country. So tell me, what does the study? What does it want to learn? And what kind of questions? Is it trying to answer right. So this study is actually speaking to answer some of the most burning questions, probably in the world right now. So how well and does it Prevent infection on Ben Secondly, say an individual does become infected who has been vaccinated? What does their viral content look like? So how infectious somebody, maybe So does the vaccine limit the number of viruses that a person is carrying? Yeah, so explain that to me. Why are these the burning questions of the moment? It's because we have been waiting for this vaccine with such anticipated And over the past year, But what we know as scientists is that vaccines they're not 100% effective, so let's be clear. Vaccinated. Individuals can pick up the virus and they can pass it on to others. The vaccine doesn't stop those things. The vaccine prepares our body to fight off infection, prevent illness, hospitalization and death. These studies are going to help us understand how transmission is curbed and how many members of a community do we need to vaccinate to hit herd immunity? Um, It'll also help us understand how we can potentially interact safely together as vaccinated and unvaccinated individuals. So the study it seems to me that it's chipping away at this question. When can
WGN Radio
"principal investigator" Discussed on WGN Radio
"It C. Vale's other world on it. Whoa! There we go. That's what that is. Hey there, everybody Steep hills. Other world on a Sunday afternoon at it. I look outside. I don't see a lot of people. Walk along the river walk. I don't know why That's the case now. Chicago Blackhawks hockey at 1 30, the Blackhawks and the stars and that'll be heard. Of course, right here on W G and Dr Richard Novak, principal investigator for Madonna Vaccine, head of the division of Infectious Diseases at University of Illinois Health. Welcome to the show, Dr Novak. Thanks very much for having me pleased to be here. Well, it's good to talk to you again, and I'll start with about a zillion text that I received and through Social media and it essence. This is the question I know about the campaign's about Getting vaccinated. Targeting people with vaccine hesitancy, But the problem is I can't get a vaccine and I will tell you question after question after question after question. That's essentially what folks are asking. Do you have any answer? Well, there is a really limited supply of vaccine Still, and that's that's the big problem there. A lot of AH large programs rolling out the minister vaccine. We had you. I help ever have a mass vaccination center open now at the credit One union one arena where we're vaccinating 1000 people a day, but the rate limiting step is not a vaccine. That accident supplies women and then by now we're in phase one B, which means that people who are over the age of 65 or essential workers. And get vaccinated, but it's not yet open to the general public. Yeah, but these are even people, You know? I mean, I've spoken to people I know whose father father in law. Whatever it may be, is like 93 years old, and that person can't seem to get a vaccine. Incidentally, I want to ask you about the Madonna vaccine in particular, which is the one You work down and thank you for doing that, By the way, What about not being able to get a second dose so they show up and there's no dose available that's happened Or maybe they aren't able to show up or cancel the appointment for whatever reason. Well, that is has been a problem. I'm when vaccine centers scheduled somebody for a vaccine they're supposed to at the time of the first shot scheduled the second appointment. And they should have adequate supply to be able to provide that that should be part of their system. Unfortunately, not everybody's s organizes. They should be in terms of maintaining that Um S o you to get some protection from the first dose, But ideally you want to get both doses to people. It protected. All right, So we just started here We have. I think 4000 phone calls. Our phone lines are filled. You could text as well. 312981 72 100. Dr Richard Novak is here. We're talking about the modern. A vaccine and W g n. It's 1 14. A little flexibility.
WBZ NewsRadio 1030
"principal investigator" Discussed on WBZ NewsRadio 1030
"If and when Mayor Marty Walsh heads to Washington. If the city were to do things by the book, Boston could have four elections between now and November of preliminary and a special election. Depending on when Mayor Walsh vacates the office and then the regular preliminary, an election this fall during a pandemic and a fiscal crisis that seemed unwise to many. So counselor Ricardo Arroyo introduced the home rule petition to just let the council president be the acting mayor for a bit the vote to get 0155 has received. Well votes in the affirmative, and one president, counselor. George, who was running for mayor voted president Counselors. Campbell and Wu, who are also running voted Yes, the Legislature must approve the home rule petition. Karen Regal WBZ Boston's news radio on the same day that Canada declares the proud boys, a domestic terrorist group. The FBI says the attack on the U. S Capitol may have been designed by the group's vengeance. Remember stabbing at a rally last year, a leader of the proud boys by the way, now under arrest, another one, faces charges of conspiracy as the investigation into the Capitol attack on January, 6th continues to ramp up. How about this? A robotics team at Worcester Poly Tech is now a finalist in the space Robotics Challenge. It's sponsored by NASA. A total of 123 teams worldwide started out in the qualifying round of competition. WPS Capricorn team is one of only 22. Making it to the final round there in the process of programming. Virtual robots to find and extract valuable resource is from the moon, co principal investigator Karlo pincer, Rowley says the goal is to use the bones natural resource is to support future space missions to harvest water will, in turn makes possible trusting makes fuel but then eventually will be used to our rockets. That will go back to where Before there were good marks, the Capricorn team would receive $185,000 if they place first. In the competition, which ends in July. Kevin Tonic left WBZ Boston's news radio is the Corona virus vaccine is about to hit the mainstream, CBS News correspondent Daniel Bacchus says. With covert shots on the way to pharmacies all around the country, a promise made by President Biden may soon become reality. People line up around the country, President Biden's coronavirus coordinator, says the U. S is well on its way to delivering 100 Million Covert vaccine shots in 100 days are seven day average. Daily doses administered now averaging over 1.3 million shots per day that news comes is called. The deaths are still rising. While new cases in hospital admissions are declining. And even as more Americans do get the vaccine, the CDC warns new variants of this virus could reverse Recent positive trends. But is there a lack of communication and education regarding the covert vaccine? And is that a factor in why some are not receiving the shots more from CBS is Meg Oliver 8% of Americans have now gotten there first shot, but reaching minority communities remains a vaccine roadblock. So are they vaccinating enough people of color? We really need to do much better. Unfortunately. Black Americans are getting vaccinated at only about half the rate of white Americans that needs to improve. People are dying. My patients are dying. My.
WBZ NewsRadio 1030
"principal investigator" Discussed on WBZ NewsRadio 1030
"Moving his covert 19 relief proposal forward on Capitol Hill. As Republicans have been looking for a smaller package, President Biden's expressing confidence there will be Republican support for his $1.9 trillion covert 19 relief package. The president, telling reporters before a meeting with Senate Democrats will govern public is important. But the president's drawing a firm line in Sand, telling House Democrats earlier Wednesday he's not willing to go lower than a $1400 direct payment as part of a covert 19 relief package. A Republican counter offer calls for $1000 payments to fewer Americans. Karen Travers, ABC NEWS Washington Blasting off to the final, so the space Robotics Challenge sponsored by NASA. Robotics team it w P I and Worcester, one of less than two dozen teams that are moving on a total of 123 teams worldwide, started out in the qualifying round of competition. WPS Capricorn team is one of only 22 making it to the final round there in the process of programming Virtual robots to find and extract valuable resource is from the Moon co principal investigator Karlo Pincer, Rowley says the goal is to use the moon's natural resource is to support future space missions. To harvest water effects face of liquid water on the moon appears water in the form of crystals and so being able to collect, it will in turn, make possible perfect mix fuels that that eventually will be used to our rockets that will go back to where four will go to mark. The Capricorn team would receive $185,000 if they placed first in the competition, which ends in July. Kevin Tonic, left WBZ Boston's news radio here on Earth A unique interesting find in Egypt. Archaeologists have unearthed more than a dozen mummies. Some of them had gold tongues in their mouth. Mummies were found in northern Egypt, many had tongues shaped from golden foil placed in their mouth. The theory is that the dead were given these golden tongues to better argue their case before the court of the Great God of Cyrus in the after life. How old are these monies? While archaeologists have also recovered coins bearing the name and portrait of Queen Cleopatra, she ruled ancient Egypt until her death in the years. BC more than 2000 years ago. Vicki Barker, CBS NEWS, London, You know Sometimes, when you ship the package, you can end up getting sent to the wrong place. In this case. Hockey sticks belonging to former Bruins Day of Ciara got shift Not dizzy, but a man in New Jersey. ESPN reports A man named Ariel Ben Abraham found mystics after we expected to receive some accessories for his clothing company. Hockey Sticks were big, too. Just like sitting with Ciara, Ben Abraham telling ESPN. The sticks are like 30 ft. Tall. That may be an exaggeration. 4 38. We're not exaggerating when we say Wall Street was this'll close to a third straight record day across the board, But Andrew Oh, day at Bloomberg. It just wasn't meant to be. Yeah, I kind of felt like a field goal in the closing seconds of the game that just missed the uprights. The Dow up 36 points at the close S and P 500 up four. But the NASDAQ, which had been up all day, and it down two points, losing that lead in just the closing seconds. Has the pandemic prompted more of us to buy more of our things online more often more of a set up accounts with PayPal, the online payment network. Reports a 24% increase in active customer accounts in the holiday quarter versus the year before that helped contribute to stronger than forecast earnings had papal with revenue topping a better than expected $6.1 billion and rode a Bloomberg business on WBZ Boston's news radio here..
WBZ NewsRadio 1030
"principal investigator" Discussed on WBZ NewsRadio 1030
"All that happens, and then 35. That's the high that's it for Saturday, But the Sunshine will be shiny 35 degrees right now. In Boston President Joe Biden is talking to Democrats about moving on his covert 19 relief proposal and moving it forward on Capitol Hill. Even though Republicans have been looking for a smaller package. President Biden's expressing confidence there will be Republican support for his $1.9 trillion covert 19 relief package, the president, telling reporters before meeting with Senate Democrats will give Republicans support. But the president's drawing a firm line in the sand, telling House Democrats earlier Wednesday he's not willing to go lower than a $1400 direct payment as part of a covert 19 relief package. A Republican counter offer calls for $1000 payments to fewer Americans. Karen Travers, ABC NEWS Washington Blasting off to the finals of a space robotics challenge sponsored by NASA Robotics team at W. P. I in Worcester, one of less than two dozen teams moving on a total of 123 teams worldwide, started out in the qualifying round of competition. WPS Capricorn team is one of only 22 making it to the final round there in the process of programming. Virtual robots to find and extract valuable resource is from the Moon co principal investigator Karlo Pincer, Rowley says the goal is To use the moon's natural resource is to support future space missions to harvest water effects. There isn't liquid water on the moon. But there's water in the form of crystals and so being able to collect. It will in turn makes possible actually next fuels but then eventually will be used to our rockets, and we'll go back to where four that we go to Mars. Capricorn team would receive $185,000 if they placed first in the competition, which ends in July. Kevin Tonic, left WBZ Boston's news radio, so Its inmates can get shorter their prison sentences by getting a covert vaccine WBZ TV reports. The Department of Corrections commissioner made the announcement in the letter day inmates offering earned good time which would grant them 7.5 days off. Their Senate's inmates will be required to read educational literature and watch videos about the vaccine and must receive both doses. Meantime, the Middlesex County jail As its first positive coronavirus case since late September. In fact, two of them two inmates at the Middlesex Jail in House of Correction and Bill Rika testing positive. Both have been placed in quarantine. Also nearly 100 70 inmates and more than 360 Sheriff's Office workers have received their first dose off the vaccine. Unique and interesting Find in Egypt, where archaeologists have unearthed more than a dozen mummies, including some with gold tongues in their mouth. Mummies were found in northern Egypt. Many had tongues shaped from golden foil placed in their mouth. The theory is that the dead were given these golden tongues to better argue their case before the court of the Great God of Cyrus. In the after life. How old were these monies? While archaeologists have also recovered coins bearing the name and portrait of Queen Cleopatra, she ruled ancient each Left until her death in the year 30 B c more than 2000 years ago. Vicki Barker, CBS News London To 38. He doesn't have a golden tongue, but he's got a golden voice. Andrew all day is it Bloomberg, the markets are climbing down. Yeah, Looking better here. Dow rising 95 that was having a tough most of the session. Up until now. NASDAQ up. 84 has to be 500 Rising 21 this after the nation's job market show signs of new life Here in 2021 Paycheck processor ADP reporting US businesses. Added 174,000 jobs to payrolls in January, far ahead of forecasts. This has nothing to do with the impending retirement of Jeff Bezos's Amazon CEO, but Harley Davidson is leaving Motorcycle makers. Boss says it is no longer selling branded apparel on Amazon's Web site because that's been undercutting sales at its own dealers. Harley is not the first iconic brand depart ways with Amazon. Nike made waves when it stopped selling sneakers and apparel on the site. Two years ago. Now gaming 98 now and you're owed a Bloomberg business on WBZ Boston's NewsRadio..
550 KFYI
"principal investigator" Discussed on 550 KFYI
"Medicines Anticoagulants, plus vitamin C, zinc and other nutraceuticals that we're using. We could really help people recover very quickly and keep people out of the hospital. And these were all medicines that we've been using. For 50 60 years they've been the medicines we're talking about are ones that have been FDA approved for many conditions that have been around my entire medical career and longer than that. We're looking we used in the first phase of illness. We used a throw myself or doctors. I clean and With think with vitamin D and high dose vitamin D actually has been shown to have a major role in helping people get well from covert and also helping to prevent the illness. And so have I. Ever Mexican and a doxy call Quinn been shown to be preventive medicines. And then if people have more difficulty breathing, we add, inhaled or World cortical steroids which are immune, modulating medicines, and they helped to decrease the inflammation. The virus causes and Yes. Then we are seeing that this virus causes a lot of tiny blood clots throughout the lungs and can affect the heart, The kidneys, intestines, the brain. And so we use anticoagulants. Well, he's our medicines. Primary care doctors use every day of their practice career why doctors have sat back and said, Well, we're just not going to do anything until people are sick enough to go the hospital. That's that's like waiting until somebody has stage four cancer. And then send him to the hospital and hoped that you might be able to save their life. If you treat really aggressively, then everything we do in medicine is focused on early, identifying the symptoms of the illness, doing the proper diagnostic work up and starting treatment as quickly as possible. That's what has me got a frustrating cause. That's ads. As I watched this, I have to be honest with you. I watched the hearing and I ended up getting angry, angry that it appears that covert victims are not being treated as early as they should should be, and are being denied drugs that could really help. Them. Did I see that wrong? Oh, you absolutely got it right And you should be angry with me in the position. I'm card of a coalition of positions put together by Dr Peter McCollough, who the cardiologists epidemiologist and he's vice chairman. Of the department, Internal Medicine at Baylor College of Medicine. I mean, a very prestigious and university, he's published over 1000 Medical Research papers. He's shared FDA safety. Investigations into drugs he chaired in the principal investigator on clinical trials. This man is phenomenal in his expertise, his knowledge his ability to look at the data. And it's just unconscionable were this coalition of over 300 positions that are from all over the world and we were in communication every day. There's Couple 100 emails exchanged by this group. Every single day about new developments about how you treat people whether the one of the medicines that are working what are the doses that are working and these air peer reviewed and You should be angry. Well, Americans should be angry. This has been a non orchestrated suppression. Rio thistles where this is what I want to know we got Dr Lee believes in the center ring. She's a director or past director of the Association of American Positions. Insurgents in your opinion, Doctor. Really, what is the number one driving motive behind some of these policies? I don't think there's any question political agenda to disrupt the U. S economy and the U. S election and the financial agenda to protect a windfall profit or Huge global pharmaceutical companies in the vaccine market you time. News Talk 5 50 K F Y I the Valley's talk station. I am your ring Master James T. Harris. We just had doctor leave the leaked into center ring of the conservative circus as she is a past director of the Association of American Physicians and Surgeons. She She? Her focus is medical freedom and free market approaches to health care. And what she said in this interview was actually mind blowing. She said that the way the medical community is handling Cove it is basically as backwards there waiting for people to come in. Come in sick. It be like, you know, waiting for somebody to get the stage four cancer before you start trying to diagnose him. Okay. This woman is an expert and one of the people that she works with the doctor Jane Orient. She was testifying before the Senate yesterday. You've heard Dr Orient into centering other conservative circuits. So all of these so called medical procedures and the things that we're doing to mitigate the covert 19 the subject governor do see is imposing on us is a bunch of garbage And we were right. When we talked about follow the money. The reason why Governor do see is causing so much pain to so many people in the state. Is political. And financial Let that sink in. It's becoming so obvious. Just like the stolen election is becoming so obvious. So overwhelmed, Overwhelming. But what do you do? Where do you go? Our courts are not going to do anything about it. We saw that which one to get. You know the Duce you to take his foot off small businesses Next. You don't do anything because we have a covert emergency. So says the governor and every other governor left leading governor in this country Yet yet we could look down. Look what's happening in Florida and see that they're not slowing down anything there. Governor, a conservative Has Florida wide open and it's thriving. New York has closed down and they got cases breaking out all over the place. And even though cases are breaking out all.
Sunday Standards
Chicago - Coronavirus in Illinois updates: 7,598 new confirmed and probable COVID-19 cases, 76 additional deaths reported Sunday
"Numbers are Ian. On Sunday, the Illinois Department of Public Health reported 7598 new cases of cover 19 that brings a statewide total number of infections to 787,573 Heidi pH is also reporting 76 new fatalities from Corona virus, which now means that 13,255 Illinois residents have died from the disease. 5160 people are hospitalized with the virus. 1103 of those patients are in the ICU with 643 of them on ventilators. A statewide positivity rate is 10.1% gave Salgado WGN. Chicago Mayor Lori Lightfoot was on CBS TV's face The Nation Sunday discussed have Chicago share of the first wave of vaccines will be distributed. She addressed concerns that people of color may not have access to the vaccine, so there will be an equity lens as it applies to distribution of the vaccine here in Chicago. And she said Once frontline workers are vaccinated, first responders will be next. She said. The city will follow the protocol set by the CDC to determine access to the vaccine. She expects about 23,000 doses in the first distribution. As Chicago prepares to receive the vaccine. We're learning about how the vaccines work. Dr. Richard Novak, director of infectious diseases for University of Illinois Health, is the principal investigator for the Moderna vaccine trial. He details how the vaccines work inside the body Express the spike protein, which is so your body makes antibodies to that spike protein. And then when you get the actual infection if you're enjoying counter Coronavirus, the antibodies you have with buying to the spike protein of the virus and keep that person getting into yourself. Dr Dr Novak Novak appearing appearing on on the the Steve Steve Dale Dale program program here here on on WGN WGN radio radio today. today. Don't Don't know know A A Democratic Democratic U U S. S. Senator Senator Dick Dick Durbin Durbin pushing pushing Congress Congress to to get get a a coronavirus coronavirus relief package
Morning Edition
Coronavirus Is Surging In The US
"One, But however you define it. Corona virus in the U. S is surging. Some parts of the country air passing more restrictions to try to combat the record number of cases this as we have yet another Corona virus outbreak in the White House. NPR's Alison Aubrey is with us now. Good morning, Alison. Good morning, Rachel. So when we say the White House we mean in the orbit of Vice President Mike Pence, several aides to the vice president have tested positive for covered 19, including his chief of staff. Nevertheless, the vice president decided to keep traveling to keep campaigning. What's the reaction been to them? You know, the decision to keep his travel schedule intact was made in consultation with the White House medical unit, the spokesperson said. Yesterday and pencils office says this is in accordance with CDC guidance for essential personnel there, basically making the case he has Essential work to do, including on the campaign trail. But public health experts Rachel are really questioning this definition. Here's Josh Sharfstein of the Johns Hopkins Bloomberg School of Public Health. He served in the FDA under President Obama. The vice president should be limiting interactions with others because he could be harboring the virus and he could wind up becoming infectious. And so if there are essential activities that he needs to do in person, he should take extra precautions to do those, but otherwise I think he should be staying at home. Especially given around the country, including places. Pence is scheduled to travel such as Minnesota. The viruses circulating widely, right, So let's talk about that. Alison. What do the numbers tell us about the virus right now? The U. S has been averaging about 68,000 new cases per day. This is about a 30% increase compared to just two weeks ago. In recent days, new cases have reached record levels in several states, Utah, Tennessee, Illinois in Chicago over the weekend. Stronger restrictions took effect of bars and restaurants must close earlier in the evening. This is part of a curfew in the city. Other parts of Illinois have stricter rules, too, including new limits on the number of people allowed together and Rachel. They're certainly a lot of reminders around the nation to stay. Vigil eight, right? Hospitalizations from Cove. It have been on the rice too. I mean, does that mean we're likely to see more fatalities in coming weeks? You know, probably there are still a lot of people dying about 775 people per day in the U. S. On average. That's a lot lower than the highs of last spring. Part of this can be explained by the increase in cases among younger people who are less likely to die. But Rachel there's also been an improvement in treating people in hospitals. Physician Anish Mata is an infectious disease expert at Emory University. He is also a principal investigator for the H M Death Severe trialled at Emory. Last week, the FDA gave this antiviral drug full approval. Red death, severe reduced recovery time to 10 days for 15 days and also importantly, run desecrated treated patients had less use of mechanical valve leaders and other advanced oxygen's airport techniques. Compared to patients who didn't get room disappear. Now it's important to point out Rachel. This is not a home run treatment. It hasn't been shown to significantly prevent deaths among very sick patients, but it does have some benefits and Allison doctors now have other treatments they can offer as well as from desperation. That's right. Doctors have more tools in the toolkit. Now they have You know steroids, such as Dixon Math Zone better information about when to put people on blood thinners. Overall, the death rate appears to have dropped. In fact, a new study that included an analysis of thousands of hospitalized patients found that at the start of the pandemic patients had about a 25% chance of dying. Now they have an 8% chance. So still high, but definitely improvement. Yeah, definitely So younger people, you know, you mentioned more younger people have been diagnosed with the virus. So as we start to think about Thanksgiving Is there any way Tio Tio ensure that college students don't bring the virus home as they leave for break? You know, if you have a college student coming home to you find out if they're being tested, many schools are offering or even requiring an exit test or a departure test. Just before students depart for Thanksgiving break. I spoke to David Paul Thiel, He's a professor at the Yale School of Public Health about this He says. Of course, it's easy to identify symptomatic people. But this isn't good enough. I'm worrying about the student who feels just fine but who happens to have been exposed recently and who could be heading home to visit an elderly relative. And so we don't want to be sending little ticking time bombs home for Thanksgiving. I completely agree that we need to have everybody tested within 72 hours of departure. Now. Not every school can manage this given the cost. But many campuses are offering departure test, including big schools like Ohio State and many small liberal arts schools, too. During such as families that have college age kids either, right? I mean, my own family. We're trying to figure out what we do anything. We're all trying to figure this out, right? Everyone started figured out. So what can you tell us of this boy now, Zim? Well,
Science Magazine Podcast
FDA clinical trial failures
"Now, we have contributing correspondent Charles, pillar. He wrote an investigative feature on SDA's serious decline in protections for patients and for data integrity. Hi, Charlie Hey Sarah, I'm not sure everyone knows that FDA has oversight of clinical trials. What exactly is this agency's role with respect to human trials? The FDA is vast agency with many responsibilities, and in this case, it has two elements of control over the quality of trials. One is whether patients are properly protected during the trials in also whether the data generated from these trials is reliable in his in keeping with the important goal of the FDA of approving drugs and devices that actually were but as you. Found in your investigation, the FDA enforcement has been light-handed slow moving and secretive. You give us some examples that you found shoddy clinical research practices, poor record-keeping that you came across in your dive into this one example that comes to mind as a organization in Utah that is a contract research organization that does clinical trials on behalf of drug companies. This isn't orgainzation that had enormous problems spanning almost decade problems with informed consent problems associated with conduct, its trials that called into question the integrity of the data in also the safety of volunteers these trials for serious kinds of drugs, end devices, including opiates, antidepressants, antipsychotic drugs, drugs for Alzheimer's and threats and. Other pretty serious ailments. What we found in looking at the FDA evaluations is that there were really serious problems that the agency itself warned the investigators might constitute for scientific misconduct, significant human subjects, protection violations, and perplexingly despite for investigations, the agency never cited this Organization for anything beyond just saying look, you're doing a bad job here. Now, never a warning letter never required any changes in the procedures. It never insisted that the principal investigator change operations in a way that would save our patients and data I just want to emphasize how important it is to protect people involved in clinical trials. Medical Experiments on human beings. and. There's a long history of unsafe practices in the bad old days. There were a lot of abuses of human subjects these days. There are pretty stringent requirements that there be informed consent of the patients who are participating in these trials that there be a very rigorous review of the trial so that these patients are well protected. The FDA looks both that the investigators and the Institutional Review Boards called I IRB's that are responsible for overseeing these experiments and what they often learn is that not just our the investigator's making mistakes or hindering their experiments in a cavalier or unsafe way but also the investigation process the review of that by the IRS. Is often not very adequate in the IRBE's themselves perhaps are run amateurishly or in a way that does not protect. Patients were the quality of the data that's generated by the experience. This is an investigative piece you've spent almost a year gathering information. What kinds of evidence did you collect well to basically every public source of data that the FDA publishes associated with their review of trials in? So that includes summaries in their various databases online. It also includes warning letters, which is when serious mistakes are made. They might warn the investigator or the I. R.. That they've got a problem that needs to be fixed, I also looked at the inspection reports that were available through the freedom of information, act on hundreds of these cases these are pretty difficult to obtain because the reports are only available under the foia in as a result, it can take weeks months sometimes years to get access to them. So what I'm trying To convey here is that this is a very difficult process. The actually lured what happened in the FDA's evaluation of these organizations because oftentimes they do not announce publicly what happened what about the drug companies that hire these institutions to carry out this research when there's really agreed just problems going on the worst case scenario is that a clinical scientist who was doing? These experiments can be disqualified from future research. This is for someone who has broken the rules and such agreed sway that they've endanger patients that they've intentionally submitted false data to the FDA here to the sponsor of the experiment. When that happens, there's no doubt that the companies who sponsored the specific experiments that were found to have been either fraudulent or so badly. Flawed those timed they're informed of it. The problem is that many times even those experimenters their long history of research is just sort of a black box. No one looks back to see him. They made similar egregious errors or conducted experiments that were tainted by fraud.
Science Magazine Podcast
FDA clinical trial failures
"Now, we have contributing correspondent Charles, pillar. He wrote an investigative feature on SDA's serious decline in protections for patients and for data integrity. Hi, Charlie Hey Sarah, I'm not sure everyone knows that FDA has oversight of clinical trials. What exactly is this agency's role with respect to human trials? The FDA is vast agency with many responsibilities, and in this case, it has two elements of control over the quality of trials. One is whether patients are properly protected during the trials in also whether the data generated from these trials is reliable in his in keeping with the important goal of the FDA of approving drugs and devices that actually were but as you. Found in your investigation, the FDA enforcement has been light-handed slow moving and secretive. You give us some examples that you found shoddy clinical research practices, poor record-keeping that you came across in your dive into this one example that comes to mind as a organization in Utah that is a contract research organization that does clinical trials on behalf of drug companies. This isn't orgainzation that had enormous problems spanning almost decade problems with informed consent problems associated with conduct, its trials that called into question the integrity of the data in also the safety of volunteers these trials for serious kinds of drugs, end devices, including opiates, antidepressants, antipsychotic drugs, drugs for Alzheimer's and threats and. Other pretty serious ailments. What we found in looking at the FDA evaluations is that there were really serious problems that the agency itself warned the investigators might constitute for scientific misconduct, significant human subjects, protection violations, and perplexingly despite for investigations, the agency never cited this Organization for anything beyond just saying look, you're doing a bad job here. Now, never a warning letter never required any changes in the procedures. It never insisted that the principal investigator change operations in a way that would save our patients and data I just want to emphasize how important it is to protect people involved in clinical trials. Medical Experiments on human beings. and. There's a long history of unsafe practices in the bad old days. There were a lot of abuses of human subjects these days. There are pretty stringent requirements that there be informed consent of the patients who are participating in these trials that there be a very rigorous review of the trial so that these patients are well protected. The FDA looks both that the investigators and the Institutional Review Boards called I IRB's that are responsible for overseeing these experiments and what they often learn is that not just our the investigator's making mistakes or hindering their experiments in a cavalier or unsafe way but also the investigation process the review of that by the IRS. Is often not very adequate in the IRBE's themselves perhaps are run amateurishly or in a way that does not protect. Patients were the quality of the data that's generated by the experience. This is an investigative piece you've spent almost a year gathering information. What kinds of evidence did you collect well to basically every public source of data that the FDA publishes associated with their review of trials in? So that includes summaries in their various databases online. It also includes warning letters, which is when serious mistakes are made. They might warn the investigator or the I. R.. That they've got a problem that needs to be fixed, I also looked at the inspection reports that were available through the freedom of information, act on hundreds of these cases these are pretty difficult to obtain because the reports are only available under the foia in as a result, it can take weeks months sometimes years to get access to them. So what I'm trying To convey here is that this is a very difficult process. The actually lured what happened in the FDA's evaluation of these organizations because oftentimes they do not announce publicly what happened what about the drug companies that hire these institutions to carry out this research when there's really agreed just problems going on the worst case scenario is that a clinical scientist who was doing? These experiments can be disqualified from future research. This is for someone who has broken the rules and such agreed sway that they've endanger patients that they've intentionally submitted false data to the FDA here to the sponsor of the experiment. When that happens, there's no doubt that the companies who sponsored the specific experiments that were found to have been either fraudulent or so badly. Flawed those timed they're informed of it. The problem is that many times even those experimenters their long history of research is just sort of a black box. No one looks back to see him. They made similar egregious errors or conducted experiments that were tainted by fraud.
Bloomberg Best
Oxford to resume trial of coronavirus vaccine it's creating with AstraZeneca, days after halt due to reported effect
"A closely watched vaccine trial is back on the University of Oxford and AstraZeneca have restarted a UK trial of an experimental cove in 19 vaccine. The study had been halted September 6th after one of the participants got sick. Oxford said in a statement that the UK regulator had recommended that the trials resume Dr Own Yama Oh Beulah Gu, principal investigator of the Pfizer, Phase three vaccine, try alight, Yale Mentioned the case today. The good news for that one participant is that it appears they're already recovering, and I think it's still unwelcome question if the disorder was caused by the passing he was interviewed on ABC is Good Morning America.
Tom and Curley
First American dosed with Oxford-AstraZeneca phase three COVID-19 vaccine speaks out
"Contenders are Corona virus vaccine has started a final round of testing in the US Get the latest from CBS Medical correspondent Dr Jon Lapook 23 year old Jacob Serrano is the first volunteer to be dosed in the US with either the Oxford AstraZeneca vaccine or a placebo. He has lost seven family members to covert 19 and says he wants to be part of the solution to save lives. No matter the cost. I know there was a break because it's like it's a trial, but I rather have us one step closer matter what it takes. Serrano was dosed on Friday at Headlands Gem Research Institute in Lake Worth, Florida Immune response was very encouraging. Dr. Larry Bush is an infectious disease doctor and the lead principal investigator for this trial site. He says he's optimistic. This vaccine is effective. More
WTOP 24 Hour News
Man who lost 7 relatives to COVID-19 becomes first American to trial Oxford vaccine
"For a Corona virus vaccine has started a final round of testing in the U. S. Researchers at Oxford University in partnership with AstraZeneca started dozing the first volunteers last week. During this third and final phase. The vaccine is tested for safety and how effective it will be of reducing or blocking cove in 19 symptoms. CBS chief medical correspondent Dr Jonathan Luke spoke exclusively with the first American participating in this trial. 23 year old Jacob Serrano is the first volunteer to be dosed in the US with either the Oxford AstraZeneca vaccine or a placebo. He has lost seven family members to covert 19 and says he wants to be part of the solution to save lives. No matter the cost. I know there was a break because it's like it's a trial. Bye. I'd rather have us one step closer, no matter what it takes. Serrano was dosed on Friday at Headlands Gem Research Institute in Lake Worth, Florida Immune response was very encouraging. Dr. Larry Bush is an infectious disease doctor and lead principal investigator for this trial site. He says he's optimistic this vaccine is effective in the phase one in two trials. A vaccine has been proven that not only do you get where bus neutralizing antibodies to fight the coroner Corona virus you get a T saw response another arm of the immune system to fight off the cells that do become infected. That's crucial in treating infections. Oxford University has been conducting phase three trials in the United Kingdom, Brazil and South Africa. Earlier phase is there was no evidence the vaccine causes serious reactions. Headlands research says. They're focuses on enrolling members of the African American and the lap next community who have been disproportionately affected by the pandemic. The numbers are pointing to that those groups of people becoming infected at a higher rate. And therefore that's a group that would highly benefit from vaccination. AstraZeneca says it plans to enroll up to 50,000 participants globally and is planning to start phase three trials in Japan and Russia. The company expects to have late stage trial results later this year. That is
Optimal Living Daily
This is What Most People Get Wrong About Willpower
"This is what most people get wrong about willpower by near a all of near and far DOT COM. You come home after a long day of work. Can you immediately curl yourself up on the couch and binge the latest Netflix's craze for hours while you scroll and Scroll your social media feeds and snack on potato chips even though you're on a diet, you look around and see that garbage needs to be taken out. Laundry needs to be folded in your child's toys are strewn across the living room floor. The list of productive things you could be doing seem endless. You can't seem to find the willpower appeal yourself off the couch to do them. Is a regular occurrence for you. Do you realize that you are in this? rut But can't seem to find the willpower to overcome it. You're definitely not alone in this situation this is called ego depletion. Ego Depletion is a theory that willpower is connected to a limited reserve of mental energy, and once he run out of that energy, you're more likely to lose self-control. The steering would seem to explain your post work defeat. But new study suggests that we've been thinking about willpower. All wrong. At the theory of Ego Depletion is true even worse holding onto the idea that willpower is a limited resource can actually be bad for you making you more likely to lose control and act against your better judgement. The real nature of willpower. In, a study conducted by Stanford Psychologist Carol to Wack and her colleagues published in the proceedings of the National Academy of Sciences too I concluded that signs of Ego depletion were observed only in those test subjects who believed willpower was a limited resource. They studied how people reacted when they were fatigued and told drink lemonade was sugar in it to give them a boost after the participants drank lemonade, the researchers evaluated how they reacted. It wasn't a sugar in the lemonade, but the belief in its impact that gave participants an extra boost people who did not see willpower as a finite resource do not show signs of ego depletion if to conclusions are correct that means that ego depletion is caused by self defeating thoughts and not by any biological limitation, and that makes us less likely to accomplish our goals by providing a rationale to quit when we could otherwise persist. Michael Ends liked professor of psychology at the University of Toronto and the principal investigator at the Toronto Laboratory for social. Neuroscience offers an alternative view. Dwight conclusions is like believes that willpower is not a finite resource, but instead acts like an emotion just as we don't run out of joy or anger willpower ebbs and flows based on what's happening to us and how we feel for example, to determine how in control people feel regarding their cravings for cigarettes, drugs or alcohol researchers administered a standard survey called the craving belief questionnaire. The assessment is modified for the participants drug of choice and present statements like once the craving starts, I. Have No control over my behavior and the cravings are stronger than my willpower. How people rate these statements tells research is a great deal, not only about their current state but also how likely they are to remain addicted participants who indicate they feel more powerful as time passes increase our odds of quitting in contrast studies of cigarette smokers found that those who believe they were powerless to resist were more likely to fall off the wagon after quitting. The logic isn't surprising but the extent of the effect is remarkable a study published in the Journal of Studies on Alcohol and drugs found that individuals who believe they were powerless to fight. Their cravings were much more likely to drink. Again, the same theory could be applied to other things as well such as working out dieting, self control and a relationship, but CETERA. A new, decision, making tool. Seeing the link between temperament willpower through different Lens has profound implications on the way we focus our attention. From one if mental energy is more like an emotion than fuel in its tank, it can be managed and utilized as such. For example, a taller might throw temper tantrum when refuse a toy but will as they age gained self control and learned to ride out bad feelings. Similarly, when we need to perform a difficult task is more productive in healthy to believe a lack of motivation temporary than it is to tell ourselves we're spent and need a break.
Doug Stephan
Russia approves first COVID-19 vaccine
"Russia claims it has approved the first Cove it 19 vaccine in the world. But there is skepticism about the product that came from the Moscow Institute. Meanwhile, work on vaccines in the U. S continues. Moderna is among the company's already producing a covert 19 vaccine before proof that it works. Everything has been Working remarkably smoothly. The patients are wonderful. They're here. They can't wait. Tio Tio make their contribution. Principal investigator Dr Paul Bradley says half the group gets the real vaccine. The other half a placebo. Everyone gets treated is that they got the same thing. On and we we wait. We watch We're looking for any side effects. Any complaints? I'm John Lawrence
Morning Edition
NASA to launch mission to Mars
"NASA spacecraft bound for Mars launches from Florida Today. It's one of three missions taking off this summer. While Mars and the Earth are in a favorable orbit. The new U. S mission is carrying something unusual for a spacecraft a microphone. From member station W O M F E Brendan Byrne tells you about it from Hiss. When the perseverance Rover lands on Mars in February, it will unpack a suite of scientific experiments to help uncover ancient signs of life on the red Planet. High tech cameras, spectrometers sensors, and this is the voice of Roger. Weeks speaking to you through the bars microphone on super Camp. Roger Weans is the principal investigator of the rover super Camp, a slew of instruments, including a camera, laser and spectrometer that will examine the rocks and soil of Mars for organic compounds, a hint that there might be further evidence of past life. Tucked away inside the super cam is the Mars microphone. And so what is there to listen to anything interesting? First of all on Mars, and so we should hear wind sounds. We should hear sounds of the rover. We might hear things that we never expected to hear. And so that's going to be interesting to find out. The Mike will also listen as perseverance is on board laser blasts nearby rocks, you might think we're going to hear like you. But you probably won't University of Central Florida Planetary scientists Addie Dove says the sounds of Martian rock blast will help scientists determined if they might contain organic material evidence of life on Mars. But it will actually sound more like this. Microphones on spacecraft are quite rare, really, because there's not much to here in space for sound waves to travel. You need an atmosphere sort of like a slinky, right compressed the sound waves in between the source and your ear drums. And then they make your ear drums reverberate. That's how we hear sound. Still, spacecraft microphones have been used before. NASA's insight. Mars Lander caught a snippet of sound capturing wind vibrations from two of its sensors, not exactly microphones. The observation was a surprise to mission managers. Engineers converted the vibrations into sound, speeding it up and shifting the frequency up by 100 times for our ears to hearing planetary society, says hearing things from another world would help build public support for space missions. For decades, The organization has lobbied for microphones on spacecraft, but those efforts have fallen short for technical reasons or lack of funding. So what will Mars actually sound like? That's still a mystery. The atmosphere of Mars is far less dense than Earth's and made up of mostly carbon dioxide. That's going to change the way sound works on Mars, says Weans. You could not hear somebody scream from a block away on Mars. On DSO. That's just that's life on Mars. But what we what we will be able to hear is our things that are close up, and it's going to still give us just a whole new world of information from this new sense that we will have on Mars. The Mike can also listen for mechanical issues as the rover moves across its landing site, Jezreel Crater. It's like when you're driving your car, and here a strange rattling sound. You know, it's time to take it to a mechanic. For NPR
Science Magazine Podcast
UK moving forward with megatrial for coronavirus treatments
"A UK mega trial designed. Test Treatments Cove Nineteen Haikai Sarah. We're talking about the UK's It's called the recovery trial and it hasn't differences with other ongoing trials of drugs for Corona virus. What are some of the big differences with recovery? The main difference in some senses said it's a really really big trial they have. More than two thousand patients now. In an outbreak like this if you really want to have really good clear, robust result, one of the most important things to include a lot of people to get a really strong signal of secrecy, that's something that recovery has been able to do, and really no other trial in the world has been able to get those patients numbers. This isn't a UK. And the United Kingdom has a lot of cases for its size. Is that one of the reasons that this trial has been success? Yeah, absolutely I mean if they didn't have that many. Many patients in the first place of today wouldn't be able to enroll that many patients some of the people I've talked to so for instance one of the scientists. He's from Norway. He was saying. The recovery trial is really successful in the sense that one in six patients that goes to UK hospital with Kobe nineteen ends up in the trial. Well, you can kinda wonder why they managed to include that many patients. One reason is that they have the National Health Service all the hospitals took part in that and the top doctors in the. The Nation wrote a letter to all the hospitals and all the staff. Saying you know here are the three trials that we want to prioritize in. Please try to include patients in these trials. If you can, so that's kind of how they they ended up with those huge patient numbers in the first place that allowed them to in a very short time. Get some some answers as a result of having all these patients enrolled and kind of coordination at the national level for recovery. They've seen a lot of results in a short time can. Can you talk about some of the drugs? They've been able to either give a thumbs up to or thumbs down to I one. That was a really big deal. Was the hydroxy chloroquine arm of the study so much has been set written about hydro or Quin, banning a lot of that was based on trials, either with very few patients or trials obsessional, so whether patients were randomized to either get hydroxy chloroquine or a different drug or placebo, but basically looked in retrospect and compared how patients did who got hydroxy in patients who didn't? The recovery trial date has the best data we have for civilian patients being treated with hydroxy chloroquine, and they didn't see a significant difference in how the hydroxy chloroquine group did versus suspended care. Group And they put that out in a press release, and within a few days, a lot of other trials that were ongoing that would clearly not have stronger results were ended. I wouldn't say it's quite the end of that drugstore quance Saga Probably, but certainly mocked the attorney on. And on the other side of the roster here we have a drug that actually help patients that were in the hospital, so that sex method zone. It's a steroid drug that's also been known for a long time quite cheap. It's widely available, so it's really nice drug to be shown to be effective against covid nineteen. There's been a lot of debate from the beginning about how much of the severe illness at the end in patients is really the overreaction of the immune system, and that's of course where the steroid drugs attack the pathogenesis really so they can have damp and. And Immune System, and the hope is that that will mean that that the symptoms of patients will be severe and people are more likely to survive, and then that turned out to be the case I mean they. They found that mortality when one third in patients that received accent medicine. That was really the first big randomized trial in this outbreak that showed a clear difference in mortality, the national. Health Service within hours after the result was announced, changed its standard of care to include some episode. This is pretty surprising. These aren't peer reviewed results. These are press release results. Yes. That's been a huge point of contention. There's just kind of tension inherent in this fast-moving pandemic between you know having really robust results in getting them out there as fast as possible and I talked at length with Martin Landry, one of the principal investigators of the about it his argument. Is You kind of get? The baseline results I. You can look at the data and see okay. There is a difference in mortality and might be some changes in the percentages, but nothing major, but then there's a lot of other data that you want to put in the paper that takes some. Some more work, so his argument was. This is an important resulted to change the outcome of patients right now so let's put it out and then try to get the paper out as soon as possible. After that in the paper ended up coming out I think seven days after the results. Yeah, it's a bit of a wild west. Now place is different. Hospitals have different standards of care like in the US. A lot of hospitals are using convalescent plasma. This is a blood product from a person has recovered from cove nineteen and they're using that to treat patients in the hospital. But convalescent plasma hasn't been subjected to the same level of scrutiny at the same level of evidence has been obtained. You know for that as a deck of Methadone the drug. We just talked about right and I. Mean that's the two points though that I find really interesting and one is. If you're going to give patients these drugs, anyway, you might as well be using that to generate data that then shows whether the drug works said they aren't collecting data on these treatments, so they are collecting data, very. Very. Often right, the problem is I. Mean it does back to what I was saying about randomized patients, you can treat patients with something and then say okay. We're collecting a lot of data and we'LL GONNA look back at how the patients did that. Receive Drug and how patients did that didn't but there's a hierarchy of evidence and really in that hierarchy a randomized trial just because it gets rid of all the bias season, who would receive a drug or not otherwise so everyone? I talked to really agree. Agree that we need in this particular situation that's condemning when you want to see as fast as possible whether a drug has a big effect on the hard outcome like do people die or do they survive what you need, a large randomized trials, and when you ask people why they do, it also goes back to what you were saying. A lot of people said when they tried to convince doctors to take part. The doctor say well, but I have a good feeling I think. I know what works, right. Right maybe I mean doctors sometimes willing to accept a lower standard of evidence to guide their decisions. It then becomes very difficult to get to that higher level of evidence because to do that. You need to accept that half of your patients are not going to receive whatever you believe to be the most useful. That's inherent tension in the whole enduring these kinds of trials when you have some observational data already, but you don't really have the kind of strong data that let's say with confidence. Okay, this worse. I'm here in the US. We have many many cases, but there isn't this sized patient group being randomized. Is that because of what we just talked about, or is it more a lack of coordination? The US has done one big trial though the National Institutes of health the first. Study that was a randomized placebo controlled trial that included a lot of patients. And did give a robust result didn't really see a difference in mortality, but it showed that patients receive from severe. Stay in hospital for a short time period. Why haven't more trials like that I? Think it is a lack of coordination. You can argue that the whole response in the US to this virus has been marked by lack of ordination, and then, of course it does help when you have certain structures in place so again. The National Health Service in the UK with all of these hospitals. Part of this National Health Service. Of course, it makes it a lot easier. You put in place this one structure, one ethical board, and then you kind of do it from there while if you have to piece together coalition. Coalition of different hospitals and different investigators, it becomes a little bit more complicated. I think right, but given the the sheer amount of cases, the US has had i. mean certainly data could have been generated that would have informed both the US and the rest of the world a lot better about what works what doesn't.
Sounds of Science
Collaborating to Cure Dementia
"Many of us will have to deal with dementia at some point in our lives whether as a patient or caregiver this terrible range of conditions affects five to eight percent of the sixty and older population at any given time. According to the World Health Organization the Dementia Consortium of Private Charity Partnership that Charles River joined last year is one of the organizations leading promising research on dementia treatments in order to discuss this condition and the research to treat it. I am joined by Sarah Almond Associate Director of integrated biology. Welcome Sarah Hi. Can you explain the purpose and organization of the DEMENTIA CONSORTIUM DEMENTIA Is SETUP BOY A? K. or outside research she k. Is a charity that focuses on. Alzheimer's disease it brings together. Active research is Pharma partners. Sarah's including Chelsea River in order to bring forward novel treatments dementia including outlines disease outside reset she. Kabc this research is invited to come forward with ideas for novel targets in Europe. Degeneration Your Inflammation Way. Them work with them to put together. What packages the funded by the partners? Anti Kate to prosecute he's talk and hopefully lead to novel treatments for Dementia. What do you think of the way? They've set up their organization. I think this is a great way to stop the organization because it brings together such a broad range of experience From academic researchers may have spent years really understanding the biology of targets to pharmaceutical companies. That know how to bring targets three two treatments actually effective in the clinic and also is a CRI where we have a broad range of so biology and chemistry capability so we cannot provide the word packages also have extremely experienced. Research is catchy. Help develop the molecules to treat these young coupled with the charitable input of the Vale Uk. He Project managed but also do so much to bring forward research in this area. Yeah absolutely cut covering all the bases. So what is Charles Rivers role in this group? You mentioned a little bit and you go into a little more detail. Charleston is WANNA to Communist with capabilities and drug discovery expertise. We provide strategic input into plans to de risk these targets and how to generate tool molecule suitable testing the hypothesis. We went with Alzheimer's Research K. And the principal investigator to proposals together. That income dreams that executed by then the appeal and US working closely together. They may do the basics. Hogging island allergy and we bring medicinal chemistry or HD CAPABILITIES. That actually will enable us to find a joke against that tailgate. We meet with the foul partners to finalize plans. And then once funded. We actually execute the work. Okay awesome I understand that a couple of research projects from the consortium have already been green lit Can you explain those proposals? She'll you're correct to Russia in progress of the two targets. One is fine as the Scott appears to link to Tau Accumulation ear inflammation. We aren't sure whether we need to be selective over a closely related kind as the. Pi is looking at whether ACHSAF. You've reduced this target. That doesn't indeed impact Taufel are. They should be China in Vivo. Mostly of onto molecule and vacation and which is a specific type of dementia or Alzheimer's. Or is that just a general Assignments towel face but particularly Alzheimer's disease at the eventual Gulf one is to the impact of the tour the killer produce on time phosphorylation. In an in Vivo model than the second project is two gene mutation I l s from tempo dementia the courses of pathogenic Rene to be produced. And we're aiming to block the expo this RNA. By targeting his with the protein takes out the Chris into the cell. When this new mix and Rene is exploited toxic repeat protein produced which then up today so responses and Kohl's neurodegenerative disease so the talk if allegations. This is actually already fairly strong. So we'll focus on producing told molecule capable of testing the hypothesis drug ability in Viva. And this is quite interesting that uses Zebra Fish Assay which is as a Pi Out Annika's scrap. The compounds can reduce the interaction between the protein. And the mutant. Aren a over So vice projects Charles River going to rub in Asia screen and then performed medicinal chemistry. Touchy try and get the molecules to kind of test with the viable targets. So how exactly is the consortium supporting this work on on these two proposals? So the consortium consists of Pharma Partners K. And they weren't. She formed kind of equal partners within that and they provide funding the project so they've also provided their expertise in kind of defining the key risks that we need to address in our plans and also technically hurt entice for example as I was research to see progress against small Stein's out payroll Consult here as a whole. I understand our work on dementia has increased substantially over the last year or. So is this because of a higher demand for treatment or is it more promising research avenues. Or is it both. I think by This been advances in understanding of neurons. Lemay tion in particular so this is triggered research projects. But also there's a shift away from the amyloid focused approaches for outside disease due to a lack of clinical success but equally dementia is still highly prevalent in and loss of US. Know people that'd be personally affected by this August. Just it's very hard Eric Tree but not one which people are going to give them. What is the importance of collaboration for researching these neurological diseases? They understand that. Probably the REAL STRENGTH OF THE CONSORTIUM. I think just touches found that there are Kiama nays area The SIS for those lost focus hasn't been successful in the clinic so it's clear that novel therapeutic approaches and needed and this takes time so rarely. We need different people to work together. Different functions work together so farmer actually reduce what they do in house and choose to those complex in return. Viva studies take years to fully establish in Zeros and so when academic academia follow charities and see arose all have complementary skill sets the they they research can be three to benefit the patient in the minimum time possible. Is it also a matter of the fact that CNN diseases are so complicated? And there's so many different factors going into the Mike. No one can be an expert in enough of the different areas of research to really do absolves ex exactly not. Yeah you know. And and so just by the nature of scientific institution you may get more time to focus on specific disease mechanisms. That PHARMACEUTICAL COMPANY. Just doesn't have the kind of time to dedicate starved to really building that level understanding but they may have a much broader range of complex models. That can actually help advance. This yet come has been unfortunately so we can you tell me about the psychiatry consortium which I guess is kind of an offshoot of the dementia consortium. Yeah it's it's basically has the same structures dimensions. Timonen is formed in consultation with a K. Who a kind of had a stake in his on. Psychiatry example schizophrenia or autism and this is obscene medicines discovery cats who are not for profit and are there the cats ponant which was set innovate UK to support innovation and use by UK business? So the psychiatry console is one of the indicates which is accelerating drug discovery and psychiatric
The Big Story
Will treating poverty reshape a childs brain?
"What does it mean to grow up for that sounded like a philosophical question? I didn't mean it that way. It's a real. How does a child's life change when they spend their formative years never having enough money living below the poverty line in some cases their family barely making it paycheck to paycheck? What don't those kids do because of that? What hurdles as a place in their path? How does it affect them? Down the road does the impact of poverty literally alter their brains. And if that's the case how can we change that a simple yep. Profound experiment aims to answer that question and perhaps even offer a controversial but effective cure for the damage. That poverty does to a child. What is that cure? While what do you think the cure for poverty is MHM Jordan Heath. Rawlings this is the big story. Shannon proud foot is a writer at Maclean's one of our favorite guests. Hope Shanna I don't either. Why don't you start by kind of level setting for us and in terms of research that has been done? What do we know about children who grow up in poverty? Okay okay so what has been known for years in all kinds of dimensions. Is that kids who grew up in poverty struggle across sort of staunching array of things. You know they tend to be physically smaller smaller. They tend to get sick more often. But for the purposes of this study the ones were most interested in are there's all kinds of of cognitive academic disadvantages. They have so that we know. Oh in very broad global ways. That kids who grew up in poverty tend to do worse in school than kids. Who Grow up more well off They have lower graduation rates. Their grades aren't as good. They have have less likelihood of going on to post secondary. But what was not known until sort of astonishingly recently is why I kinda Kinda came to think of the analogy as as you. You know we knew that that kids who grew up poor would kind of emerge from the woods when they finished childhood different point than richer kids but nobody had thought to look at the path of how they got there. Because there's different ways to have poor academic outcomes right which of their skills were lagging. What was what was going on there? And so one of the principal investigators on this new new study that I've written about Kimberly Noble who works at Columbia University. Her huge splash. She made early in her career. She's a neuroscientist was looking added. Exactly why it is. That kids who grow up poor tend to do more poorly in school and and and cognitively I'm so sh- she sort of unpacked the specific skills the specific regions of the brain the the wise in house of how poverty affects how kids process information and achieve academically later in their lives. And what does she learn so the big takeaway is that Kids who grew up poor tend to lag in language skills like reading and vocabulary and also in sort of what we might think of self restraint skill so the ability to ignore distractions to concentrate working memory that kind of stuff and then subsequently Noble Co authored authored. A big paper in two thousand fifteen. That made a huge splash again. In this area of academic research where they scan the brains of just over a thousand kids and teens and the average sort of the size of their brains they were looking at primarily. What's called the corneal surface area? So this is the the outer wrinkly part of the brain. It does a lot of the heavy lifting cognitively early and when they sort of correlated different different aspects of these kids profiles the one thing they found that was consistently associated with the size as of the coral surface area on the brain was family income so that raises all kinds of interesting questions about what's going on there and not immediately makes the leap to me. It's so compelling because it makes the leap from okay. There are different skills or different strengths. That kids were better off. You know have that kids who are poor. Don't but it's physically. We possibly reshaping their brains or at least associated with a different shape and size to their brains which is quite profound. It's something that you would just never expect to see proven. You might see the results of it but to prove that correlation is quite startling right and so using the word correlation Asian here is important because what Nobles Research and other people who've been working in this area consistently over the last couple of decades has shown is that we know that poverty is associated with all all these negative outcomes. That's correlation what nobody has been able to show is causation. Has What you could do is pull that apart and say okay but is it really. The fact that these kids are poorer that their brains are smaller. They have a harder time with these skills or is it that poor families are more likely to be in a single parent situation or have substance abuse or live in neighborhoods. That are kind of scary very like you just can't and scientifically say that it's the poverty that's causing this. You can only say that the poverty sort of shows us that this is occurring. So that's where this is new unbelievably ambitious but also incredibly simple and elegant study comes in that started about a year ago it will be ongoing for the next several years before we talk about that. Study because we're GONNA spend a lot of time on that. You mentioned that we tend to think and think of and treat the various disadvantageous effects of poverty offers. You know the the school skills that these kids can struggle within. What have we traditionally done to help them? When when those difficulties manifest yes there's sort of different steps along on the way where you could intervene if you start to notice that a child in grade one is struggling in school? And you know. They come from a disadvantaged family background where there's all kinds of ways you can kick in tutoring. You can have them go to special classes for extra support. You can make sure that there's an individual learning plan in place but those things tend to be a really ambitious that costs a lot of money either very time intensive and they happen quite late in the process because research shows that kids you know from from the age of two or even earlier you can already see the effects of poverty so if you're not able to identify the kind of downstream effects the symptoms if you will until they're in school and then try to sort of intervene and turn back the clock. Obviously that's a much much more difficult proposition. If you think about kids growing up in poverty have certain life experiences that appear to affect their brains in certain ways that then affects their learning potential potential. Well depending on where you intervene in that sort of stream of cascading effects it might be a bit easier. What if you could inoculate the kids against that whole all domino effect starting in the first place? It's almost like rather than intervening after someone has fallen ill with the disease in his experiencing symptoms. Would if you gave them a vaccine that prevented I'm from ever getting the disease in the first place. Now I'm certainly. This is just a creative analogy. I'm using calling poverty or its effects a disease but it sort of suggests that if the study study is born out there may be a more elegant more efficient possibly even simpler more effective way to kind of intervene earlier in the process before or the negative effects of already kicked in. And then you're trying to undo them so explain the study now and what it does. What is I guess it's called babies first years. Yeah babies first year so it's hugely ambitious. Seventeen million dollars in public and private funding very heavy hitting academic experts from across the US primarily so they're six principal investigators instigators who are sort of the top in their field at different institutions in different areas of expertise you have neuroscience economics sociology education. Things like that at what they did is they went to Maternity wards in four cities so they picked out New Orleans. Minneapolis Saint Paul New York City and Omaha and they deliberately picked cities cities where they would get kind of a nice cross range of rural versus urban different demographic make-up's and they recruited one thousand mothers within days of having their babies so they recruited created the right from the hospital to enroll in this study and there is effectively again because they're trying to establish causation. There's effectively a placebo group or control group and a treatment group and so all of the MOMS who are enrolled in the study will receive a debit card and every month money will be loaded onto that debit card. So sixty percent of the MOMS will receive. What's called a nominal amount of money? Twenty bucks so enough to be worth their while to stay in the study but not enough to really make a huge difference and that's essentially the placebo where you're giving them money. You're giving giving them a debit card. You're keeping them in the study and keep tabs on them and their kids but the amount of money is not really a difference making amount and forty percent of the MOMS in the study those in the quote unquote treatment in group are going to receive three hundred thirty three dollars a month. So that adds up to four thousand dollars a year which depending on your income bracket may or may not seem like a lot of money but all of the MOMS in this study are at or below the poverty line and so the idea is that because the families the MOMS and kids in this study are randomized into one group or the other? They're it just kinda drawn by a computer. If at the end of the study there are differences between the group that got more money in the group that got less then you can scientifically solidly say that. It's because of the money honey. That is the difference between the two and that would finally allow them to establish causation as opposed to just correlation in terms of poverty and all these negative in outcomes for kids. Well how will the study proceed. And how will they attempt to kind of measure this along the way. They've already started with what they call through to the year. One so what. The idea is that they will check in with the the kids and MOMS around the kids first birthday second birthday. Third Birthday the study is funded up to that point so far but they're now applying for continuous funding and there is is a pretty good precedent of really ambitious. Recall Longitudinal Studies that follow people over time being extended so you can easily imagine that maybe the study won't end when these kids are three. It might follow them until they're five until ten until they're twenty. There's fascinating possibilities there. But they will bring them into the lab and obviously the kids would be turning one to three on a rolling basis because the mom's been recruited all year. They'll do some brain scans of the kids. They'll talk to the moms about sort of how things are for them. On a day to day basis it will take a hair sample of the MOMS which allows them to measure stress through cortisol levels built a video of the moms playing with their kids so that allows them to kind of code for look at the quality of interaction between the parents and the kids and sort of how they're how they're mood is with each other and eventually down the road as the kids get a little older closer to three they will do more. Ambitious brain scans functional. MRI To show them better sort of specifically how the different areas of the brain are working size of the different areas and to really unpack sort of the differences that may emerge because they they don't know the end the research researchers very open about that. We can talk about what they think might happen. But they really don't know and either way the study should come out with a pretty fascinating fascinating robust answer about would if the real problem with an he's problem in quotes but if the real problem with poor families or four families is chess money and what if you just give the money like what if you don't worry about stuff like do. They have enough books in their house. Other kids enrolled in good preschool programs. You know do. The parents have a harmonious oneal relationship. Would have you just give them a chunk of money. Does that change everything a little bit. It's it's kind of has amazing possible implications or the answer might aby. No you know what it doesn't change that much. There is too much stress in the lives of these families. There are too many factors going on that money. Just can't cancel out so either wait you sort of end up with a really interesting answer will not put too fine a point on it but I can imagine that if this study did prove causation. Shen and did prove that look. It's not any of these other things it's just money that would really blow up some of the stigmas that are attached to kids in poverty. Yeah I mean there. There are obvious quite deep political implications here existential implications. You Know People's ideas about why some people have more. Some people have lost their ideas about how we as a society should help people or how much people should bootstrap themselves up. Those are pretty deeply held things right. Those are sort of the maybe the most hot metrics of by which we sort of see political divisiveness right now. So yeah I mean you're not going to convert vert everyone but it's always an interesting thing to have a solid scientific answer. You can point to know. The researchers are very careful to say they're not suggesting this panacea. They're not saying we should get rid of of all these ambitious. You know preschool improvement programs or parenting classes or anything like that and just give us families envelopes of cash. It's more that this is an interesting idea. That's worth testing. That hasn't been tested because there have been decades of testing that have gone on around. You know preschool programs parenting all that other stuff so we should road test this one too and no. It is a useful tool to have in the toolbox but absolutely if the answer comes back that guess what if you give poor families four thousand bucks a year. It improves a bunch which of things by enough to matter. Then that might suggest that maybe the only problem with those Pam families was that they were poor and if you give them a little leg up on the poverty already they can sort of solve all the other stuff themselves. There's also all kinds of other expectations baked into this about how poor people spend money and musicians about finances. And I when I asked I asked Kimberly Noble. Do you get us by people. Like what if the mom spend the money on crappy stuff like what if they make poor decisions in there you know buying liquor Acre cigarettes or whatever and she laughed and said we get that question all the time. It's one of the first things they get us because there's no strings attached to this money but the answer is that that just it doesn't really happen. They did a small pilot. Study to sort of test the feasibility of the debit card thing and out of I think it was eleven hundred transactions. Exactly three occurred at stores that could be considered liquor stores.
Environment: NPR
NASA Taps Snowstorm-Chasing Team To Improve Forecasting
"If you live in a place where it snows you probably know. The drill forecasters will predict a massive snowstorm. Grocery stores are emptied. And then there's just a light dusting getting. It happens every winter in part because we don't really understand how these storms work but a new study from NASA hopes to change that the impacts mission wants to improve our understanding of snowstorms and in particular of what are known as snow bands. Here to talk about the program. Is Lynn mcmurray. Principal investigator on impacts. Welcome thank you happy to be earned. So what exactly are snow bands. I've never heard this phrase before. Okay well within snowstorm which you have heard about the clouds associated with them Spent a large area. They can be you know is as far as Florida up to Maine but within those clouds. You have narrow regions where the snowfall is far more intense in the oftener organized in kind of a narrow narrow band and we just call those snow bands. Okay and how do you examine closely. These snow bands. I mean I understand that you're using to tair planes. Yes so this project a way we were going to investigate. These storms is fly to different aircraft. The first aircraft after fly high above the snowstorms. It will be equipped with remote sensing instrumentation. Okay and then the second aircraft will be flying inside the storm itself. I inside. It's making a different kind of measurements. It'll be measuring the environment in which the snowfall occurs. And we have these instruments called probes which which actually take pictures of the snow crystals themselves different altitudes you see different shapes crystals is absolutely fascinating. Eighty okay so how do these two planes help us understand how to predict snowstorms. So what we're going to be doing is investigating being the processes that create these snow bands. So trying to understand the science behind it and then also by because the one that's flying high has remote sensing instrumentation will help us be able to sense it from space better. The information from the remote sensing point of view view up above in inside. The clouds will also help us improve our forecast models which predict snowfall but need better Information about how that forms sue. How accurate do you think this study will help us get our predictions when it comes to snowstorms? Well hopefully much more accurate than we have now. right now do okay with the track of the large-scale storm certainly by twenty twenty four hours ahead of the storm but we don't have a good handle on a accurate predictions of the distribution of snowfall. Where it's going to snow heavily Lee where it's GonNa snow not at all and that's to do with these very small-scale narrow bands of intense snowfall so ultimately we'll have better forecasts of whether Boston or New York will get the most Snow Lynn? mcmurray is the principal investigator on Nasr's impacts mission. Thank you very much for joining us