17 Burst results for "Plastic Syndrome"

"plastic syndrome" Discussed on The Stem Cell Podcast

The Stem Cell Podcast

04:37 min | 2 months ago

"plastic syndrome" Discussed on The Stem Cell Podcast

"They have deletions in all our part of chromosome. Seven while you know it's like fivefold lasts only about five to ten percent of the de novo amounts carry this deletion so that kind of suggests amongst other things that he's therapy related syndromes arise by a distinct mechanism from the the age related or whatever the other am l. danilo so that brings us a cam t to see. It's one of the tumor suppressors that have been defined and it's on chromosome seven it's shown to be deleted recurrently in Leukemia's that involved chromosome seven But despite this tumor suppression function so suppressor function when you knock out can t to see you. Don't get cancer. The mice don't get cancer and when you look at Age related colonial amount of tumors. You know in older human patients. You don't always see. This came t to see mutation so it it suggests that the deletion of can t to see alone doesn't cause cancer doesn't give a strong advantage to these malignant poetic cells and that it only giving other data the frequency in these therapy related that it only arises when you have these cumulative chemo cycles right so that was the basis for this. Study then you know cutting to the bottom line here with the mcgilla showed. Is that the way that came t to see works. And the way that the dysfunction came to to see works to bring about disease is that enhances the self renewal of stem cells but it doesn't alter their proliferation. Proliferation rates on specifically it. The deletion mitigates the the histone methylation in that occurs as As a matter stem cells cycle typically response to chemo. Hit them with chemo. And typically the agency cycle and they differentiate but the deletion of cam t to see mitigates that the epa genetic changes it mitigates that recruitment and in in inhibits that differentiation And that explains why you see these deletions more common in the therapy related than ended the novo. Because you need that. Prompt you need that. Insult of the chronic chemo to bring about the the enrichment of these cells in the absence of cam t to see so. It's an insight. It's an insight. On how maybe we could mitigate the The emergence of the syrup related mile. Despacito this plastic syndromes maybe by restoring the function of t to see supplementing protecting so. You know it's it's. I think it's a nice a nice study that that sheds light on something that we've already observed in the literature and assigned some mechanism to nice study. That's also reinforcing. The fact that cancer treatment itself is such a nightmare. I'm somebody who studies the effect of chemotherapy on the heart. And they're so many drugs out there that gather they can help alleviate the cancer phenotype but they can cause so many other issues too. So you know. There's a huge need for really improved. Targeted cancer therapies. So that you don't have some of these other off. Target effects of the chemo itself. But hey this is a perfect lead into our our guests today. The one and only dr willie lynch who back in the day was a an hse biologist himself a an expert on all things blood related. Just like you. I don't know from an expert. I have the interest though. But i guess that does bring us to our interview with william and she was trained in amount of who uses in malignant amount of police said. Oh s you. And that's what led him to his post ac post doc at the daily lab where he had tremendous and outsize impact in multiple fields in induced pluripotent stem cells. He's gonna tell us all about that But before we get to that. I have a quick message from stem cell. At the beginning of twenty twenty stem cell technologies conducted a survey asking scientists to help highlight the needs and challenges in the human pluripotent stem cell field..

william willie lynch today ten percent twenty twenty stem cell techno one about five Seven seven
"plastic syndrome" Discussed on WTVN

WTVN

04:22 min | 5 months ago

"plastic syndrome" Discussed on WTVN

"Blazer show. Along with Josh sees Thanks to the big basement dr dot com providing our live stream on 16 w tvnz Facebook page I am I guess just now is when this cause of death He's coming out now about Eddie Van Halen, right? I mean, we kind of knew what was going on. Yeah, he the TMZ over the weekend, apparently obtained his death certificate. And I can't remember, but I think they said it was like a cerebral vascular events such as a stroke, right? And then some blood disorder that I had a hard time pronouncing. Yeah, man isn't just plastic syndrome. Imagine if I'm a doctor, and somebody was sitting across from me and I'm like you've got on road One plastic syndrome. They're like, Say what? And I'm like You heard me. Stop it. Pneumonia, pneumonia, then. Lung cancer. Yeah. These are all underlying causes that they're citing those with the underlying causes. Yeah, they're also see listed a number of other significant conditions, including he's had. I did not realize how skin cancer he's had skin cancer. He had oral cancer. And then he and then after getting motorcycle accident back in what was that 99 or 2019? They discovered a brain tumor. So he was in a motorcycle accident last year. Minor I didn't even know about that. But I mean, like the guy was just riddled with all kinds of cancer. It was sad, atrial tribulation. Um, condition cause irregular heartbeat elevate Stroke risk. Well, that makes sense. If that was an underlying, and then he had that cerebral vascular events such as a stroke now, so he's riddled with cancer. He's got blood disorders, pneumonia and then the stroke is what killed him. It's kind of like how you the how they play the game, so covert on death certificates. It's like No stage four liver cancer, You know, heart disease but died of cove in you know that. So we're watching my wife likes watching Valerie Burton. Ellie, she does a calorie Merton Ernie Valor. Virdon, Ernie. She does the cooking thing, and she actually is a very good cook. When you watch her stuff and you watch her on TV and you know, fat No. What? Oh, my. Oh my gosh, I said facts of life. One day at a time was her show, right? Said Facts of life. You go way back when she was on. That means she's She's very comfortable in front of the camera. How she's very personable. She seems like somebody you would like to hang out with when you watch her her Valerie, of course, being Eddie's ex, and they divorced many, many years ago, but stayed friends but stayed friends because of Wolfy, obviously, and he was there. He ended up being the Bass player's player after Michael Anton. He left and so on. So I'm telling my wife yesterday go. This was on. We're watching I go. What age do you think Wolfie realized? My God. My dad is any fan Halen and was arguably a guy who changed the landscape of guitar playing and rock and roll and just go check off all the boxes. I wonder what age he determines, like Ding. He's like, man, My dad's e V H man. You know, probably 10 minutes. Overwhelming 10 or 12. I mean, I was little bit really. I thought it was also interesting to like I wanted you to know you were telling me something about him as well. What? He Yes s crazy. We all remember that. Dimebag Darrell Guitar player for Pantera and had his own band. After they broke up, was shot and killed over at the Roosevelt Roosevelt up now. In December of 2004 crazy one of the most tragic incidents in rock and roll history, and then we all know that that police officer First name is James. I forget his last name. Or maybe his last name was James Niggemeyer. Near you. Go. Thank you. Oh, yeah. Yeah. Had to literally Blow his head off on stage the gunman to stop the massacre or else who knows how many more people have died? 12 gauge So Dimebag Darrell was the world's biggest Van Halen van it I mean, he worshiped the ground. Eddie Van Halen walked on. They.

Eddie Van Halen Virdon skin cancer Pneumonia blood disorder Lung cancer Valerie Burton Van Halen James Niggemeyer Halen Josh Ernie Valor Michael Anton Ellie Wolfy Pantera James
"plastic syndrome" Discussed on NEJM This Week - Audio Summaries

NEJM This Week - Audio Summaries

02:25 min | 8 months ago

"plastic syndrome" Discussed on NEJM This Week - Audio Summaries

"Visit characteristics. Female PCP's generated equal revenue but spent fifteen point seven percent more time with the. Patient two point, four minutes. These results were consistent in subgroup analyses according to the gender and health status of the patients and the type and complexity of the visits. Female PCP's generated less visit revenue than male colleagues in the same practices owing to a lower volume of visits yet spent more time in direct patient care per visit per day and per year. Milo dysplasia syndromes a review article by Mario Cazzola from the fund. That's Yanni. IRC S Polyclinic Oh San Mateo Italy. My Lotus Plastic Syndromes MD s are Clonmel Hamadeh Poetic Disorders involving morphological defects and peripheral blood sight appeanas with a risk of progression to acute myeloid leukemia. Ds, occur mainly but not exclusively in patients with a median age of about seventy years and the crude incidents is four to five cases per one hundred, thousand persons per year, the growth and spread of. So medically mutated clone represent the pathos physiological process that leads to mdis and initiating driver mutation occurs in Hamadeh poetic stem cell that provides growth advantage over wild type cells. It's my progeny give rise to clone all polices which progressively expands and becomes dominant in the bone marrow site. A penny in at least one hematological online is an essential diagnostic criterion for MD.. s once common causes of Sido Pena have been ruled out. The conventional diagnostic workup includes bone marrow aspiration to detect morphological displeasure and lasts bone marrow biopsy to assess marrow cellular and fibrosis and conventional cytogenetics to detect non random chromosomal abnormalities. A patient centered care model represents the best approach to treatment. The initial step is assessing.

Clonmel Hamadeh Poetic Disorde Mario Cazzola Yanni San Mateo Italy Sido Pena Hamadeh MD..
"plastic syndrome" Discussed on KLIF 570 AM

KLIF 570 AM

05:09 min | 8 months ago

"plastic syndrome" Discussed on KLIF 570 AM

"A hotel? You think the hotel is going to be I'm sure there are some nice hotels out there right now and ugly letter, but Eh? Sterile enough location and much less quiet enough location for somebody who just had this particular transplant done, and they have to be isolated for 100 days. And the cost itself. 100 something dollars A night times 100 nights. No, plus your meals you know, we provide were one of only a few houses that provides all three meals thanks to our incredibly generous community who comes out and cooks for our families, But No. We provide all their meals so they don't have any meal costs. We have laundry facilities that and we provide the laundry soap so they could keep up with all of that. We provide their free haircuts. We have activities for the families. You know, we really try to make it kind of a one stop shop and have everything that they need right here. So that so that really their whole focuses just on getting their child will? Yeah, and enjoying To the best of their ability their time while they are here with their other siblings, because again, a lot of them are going to come in. That's something too that should actually be brought up is the child who is going through treatment and one of these hospitals. Oftentimes we'll have siblings. The entire family is able to come here, as opposed to Mom and dad having to leave. The other Children, maybe with a relative grandmother and uncle, relative whoever 100 miles away 500,000 miles away, so that they can come be with the child that's receiving treatment school or talk a little bit about that. When the child the child is in the hospital. Is getting their school. We're taking care of D S T. Teachers there, but they're siblings here logically still have their school work to do as well. Well, kind of depends on how long they're going to be here we've had if they're here for extended periods of time, we've had them enrolled in the elementary school or the school's right in our neighborhood. And so they continued to go to school here or they get homebound teachers that will come and we have a study loft and they can come in there and the library. So wherever they choose to go, they'll come and do the teaching there. Sometimes if they're here for about a week than that, and they know in advance that their home teachers will send work with them, and they'll they'll just bring their schoolwork with him here and then we needn't will provide tutors. We've got a lot of Teachers who are actually volunteers. And so we just send out a reason. You know an e mail to our volunteer base and say, Okay, we need somebody who can come help one of our kids with chemistry because that's not going to be me or me. So it's great to have a great group of volunteers, but we do. You know, Obviously we want to support them in any way we can so that they could continue their education. Continue some normalcy. Our family from Egypt. The sun is enrolled in the elementary school and the younger boy who's forests and head start and they're you know they're here for a long time, so they obviously don't want to get too far behind in school again. My name is hard. It's impact taxes, talking with Ronald McDonald House of Dallas. They are On bangle 47, 07 Bengal and Jill come back is a CEO. She has been for a couple of years now here, one of the things that's not in the room that seems odd at first is a TV but Jules going to explain it, and it makes sense if there's no TV in there, and the main reason is that the biggest benefit for families who stay at the Ronald McDonald houses the opportunity to meet other families who are going through similar circumstances. So if they're coming from some small town in Texas there, child may be the only child who has left heart hope a plastic syndrome when they're born, and they don't know anybody else who's going through that. Who has to have these multiple surgeries? They don't Nobody can. You know they've got their friends and family who want to support them, But they don't get it. Here we have Moses. We have our own little moms groups because oftentimes we'll have four or five families like that. At the same time, they have the same surgeons. They're going through the same surgeries. They understand the challenges that these that they're going through, and they can They bond and connect so quickly and become lifelong friends, and it truly is helpful for the families. To make another Other folks who were going through similar circumstances. It also gives them some perspective because they may come here thinking that what their child is going through is the worst thing in the world, and it is to them because that's their world that they get here. They see other kids who may or may not make it. They know that eventually their child's going to be OK. It just helps them understand. And if their child is not going to be okay, and they may lose their child that they're seeing other families are going through that. And and it just helps him to know that you know we're not doing this by ourselves. We're not alone. There's other people who were going through it, and they just support each other. So that is thie primary reason that we don't and we have all these great activities that groups come in to provide for our families, and we want thes. Our families that stay here, Tio. Enjoy that and have benefit from that. And for the civilians and the parents when we do art activities, I think that the adults the parents get this and grand parents that air here aunts and uncles. Whoever is here with that patient. It is much out of that It could become very therapeutic and it benefits them as much as anybody else..

Ronald McDonald House of Dalla D S T. Teachers Ronald McDonald Egypt Texas Jules CEO Bengal Jill
"plastic syndrome" Discussed on Mayo Clinic Radio

Mayo Clinic Radio

05:53 min | 11 months ago

"plastic syndrome" Discussed on Mayo Clinic Radio

"Clinic. Radio I'm Dr Tom, chives and I'm Tracy mccray, a bone marrow transplant also known as the stem cell transplant is a procedure that transplants healthy blood stem cells into the body to replace damaged or diseased bone marrow, and the cells can come from your own body. They can come from a donor, or they can come from umbilical cord blood stem cell transplants are often used to treat cancers most often cancers at the blood or immune system. Those examples would include leukemia, lymphoma and multiple myeloma, joining us in studio to tell us more is the director. Director of the bone marrow transplant program at Mayo Clinic hematologist. That's blood specialist. Dr William Hogan Welcome to the program. Dr Hogan thank you very much revenue. Tell us about the the bone marrow and stem cells essentially when we're doing a bone, marrow, transplant or a stem cell transplant, the idea to try and replace the disease bone marrow with healthy cells Sometimes we use the person's own cells, and that's appropriate for certain diseases, such as multiple myeloma or lymphoma, where the cells that we collect are not usually contaminated by the underlying disease for other diseases such as leukemia. Plastic Syndromes, we have to use south from a different person because the cells that we collect maybe contaminated by the disease, so there's two different types. There's one which comes from yourself autologous transplant and one which comes from somebody else and allogeneic transplant. The one where we collect you, the dialysis machine called Co., for Isa's is called a blood stem cell transplant. The one where we collect from the palace is called a bone marrow transplant, but sometimes we use the term. Bomar transplant locally. Now, what are these stem cells do so? The stem cells are kind of like the seat cells. If you have a garden and you plan seats, the what produce all of the plants. In the garden similarly for us, the stem cells produce red cells that produced hemoglobin that help us function and allow us to supply oxygen to our tissues, the white cells which helpless fight off infections and the platelets help prevent us from meeting. You mentioned that you're replacing a diseased cells in someone's Mero with fresh good stem cells. Are Almost all of these patients who almost all of these patients have. Or are there other reasons why someone might need a transplant? Yeah, that's an excellent question. The vast majority of our practice are patients that do have a form of cancer, usually blood cancer like lamm former multiple myeloma leukemia. My Plastic Syndrome by the way explained. Milo displaced central so my Otis plant stick syndrome. The old name used to be called pre do Kimia. This is a condition of the bonar with a bone. Marrow doesn't work normally, so it can result in two problems one is where the failure of the production of the cells in the bone row, or that they can convert into a form of leukemia, so it's an abnormal bone marrow problem where you can have either failure of production or transition to acute leukemia. How long have you been using stem cells to cure these or to solve these problems? So this goes back to the original bone marrow transplant was done in nineteen, sixty three at Mayo, and since the late nineteen eighty s early nineteen ninety S. we've been using more perfect stem cells, so you mentioned that the type of stem cell transplant by the way I think you were going to explain to us. Why you do these transplants, cancer is the most common reason, but there are other reasons. In our practice, the vast majority are blood cancers, but there are other types of cancers, so for instance germ cell tumors, which can affect a testicle, sometimes can be treated with a bone marrow transplant, and then there are other variety of diseases like immune disorders, bone marrow failure syndromes, diseases like sickle cell disease are Fallacy Mia, that can also be considered for transplant, and then tell us a little bit more about the source of the stem cells it depending on the type of transplant, so for some people that can come from the person themselves, and that can be bone, marrow, or peripheral blood, but almost exclusively now we use peripheral blood for that indication. For getting them from a donor, we have a number of options. The most common one that we would like to use is a matched sibling or brother sister donor, but sometimes we can use other family members and what's become more popular recently and more effective is half matched transplants are happy to identify transplants and oftentimes this expense donor pool so in a patient that doesn't have a matched brother sister than we may be able to consider another family members such as a parent in the case. Case of a child that has a disease or a child, the case of an adult that has the disease as a potential donor and with the recent technology that's allowed us to do half match transplant more safely. This is actually become a very significant of technology that's allowing access to a lot more transplants for patients, so it would seem to me like if you had the opportunity, you would always used the patient as the donor. Because then. You don't have to worry about rejection. And so tell us again why it is. You always do that for certain diseases. We know that a person's stem cells can be useful, so for instance multiple myeloma lymphoma frequently because the cells we collect don't are not involved by disease that we're trying to treat. Then we can give high dose chemotherapy to try and reduce our radical, the underlying Myeloma or foam, and then use the stem cells as a way to just repopulate the bone marrow after the high dose chemotherapy in that situation, most of the effect of the transplant is relying on the high dose chemotherapy and the stem cells are dare to repopulate the bone marrow. In an allogeneic transplant, the cells that we collect are not feasible one that we can't collect enough because they have an underlying bone marrow disease that doesn't allow us to collect the cells or that they're impacted by the disease south in the South we put back in would be malignant, and therefore wouldn't be a very good option so umbilical cord..

multiple myeloma leukemia Dr William Hogan director Mayo Clinic Dr Hogan Dr Tom Tracy mccray Isa lymphoma lamm Milo
"plastic syndrome" Discussed on EconTalk

EconTalk

14:43 min | 1 year ago

"plastic syndrome" Discussed on EconTalk

"To be a wreck emotional wrecks we have to help them and that comes from Really taking a human interest which means you have to bring all your emotional spiritual physical intellectual abilities to bear and learn how to concentrate and focus on what is The patients really shoot Not just the cure part but the healing part of it is act as important. I hope that answers your question in the aftermath of Your loss of your husband. You're right about the profusion of inappropriate things that people say and temps of consolation. I think about this From time to time I think people blunder Badly in in Jewish practice when you go to the home of a minor Jewish law says that. You're not to speak until the mourners speaks and I think people find this very difficult Our silence makes us uncomfortable and we tend to blur out things that often or worse than being silent. And you talk about that. Is it example on your own personal situation? But I've always thought about. This is one of those rare examples. Where a black and white rule like that is actually quite helpful. Sometimes those rules are just the best we can do. But the idea that to sit in silence with a person who's suffering saying nothing which the that silence yelling at. Us Often Talk Talk. Talk say something and just to sit there. And what the other person's speak I and I've always thought that injunction as being about allowing the is to keep you from saying something inappropriate but I think it also has a deeper meaning. Which is it's to get to listen. It's not just don't talk. It's listen and I'm curious. I I liked that rule. I think it's a really helpful rule to start but I'm curious what advice you would give people in situations of tragedy for how to behave and how you you don't have to go into the ones that didn't help you but I'd be curious if you would talk about some of the ones that that did help. I mean they were some wildly absurd reactions from people like Somebody gave after how he died and offered to take me out to singles bars and other person Wanted to Console me in a way but the manner in which she did. It was quite outlandish. Ezra I'm so sorry. Harvey died. But don't worry you'll join him soon. And you too can live happily. Ever after in heaven that was really breathtakingly strange to me And then there was that one of his gone but you look great that one. Don't be sad. You look fabulous. I think there's a terrible challenge in our culture is days that no one's allowed to be unhappy already. You know morning is against the rule so if if you look sad. I've got to try to cheer you up. I can't ever just let you be sad. GotTa find something. Your food's delicious. Your House looks great but lovely outfit. Yeah but it's actually the inability of people to communicate with each other. It's not particularly. I mean especially emotionally. So what you see around. You are people who are unable in fact not just to communicate with each other but then do give sympathy and to receive sympathy also in a way. It reminds me very much off the sound of silence by Simon and Garfunkel because basically that is the meaning of what is the sound of silence. is it the rustling of leaves. The sound of silence is is. Is it a flowing water? Brooke when you're sitting in a forest and listening to the sounds of silence. What is the sound of silence between two individuals and specially one one is A caregiver and the other is a patient. Very important to be able to take advantage of this kind of of syntax. I think that some of the Best Times I. I'm very lucky. Actually Russ because the tree the disease that I treat Mine Otis Plastic Syndrome as you know the pre-leukemic condition so patients live a long time off and then We have a very unique way of developing long term relationships. Because I'm seeing them every week or every other week and taking them. Through many many physically demanding situations like severe profound. Anemia compromising the quality of life Deeply and yet giving them blood transfusions which suddenly reverts them back to an energetic sell for a few days and when I see them during those days there's so different than where their hemoglobin was six grams and taking them through this for sometimes ten and twenty years and meeting them regularly. Every two weeks is a very unique privilege and in this In these interactions There are many times when we are just listening to music listening to things together or silence actually but being together and then suddenly speaking up and communicating at a level Which is so profoundly different. I think silence is underrated. One of the advantages of being the host of this program is I've become a better listener and forced myself to become silent us. Thinking about the Episode I did recently with Ryan holiday where we talked about Marina Brahma Veg. Who Sat in silence for days across from Stranger set of hundreds of strangers at the Museum of Modern Art for an exhibition a few years ago. That documentary was made of it. It's an extraordinary documentary. And I think we have a tendency to think silence is. Nothing sounds wasted. Silences is when nothing happens and yet for me increasingly as get older and get better at silence. I'm not great at it. I get a little better there the deepest times. The most unforgettable times are often just being present for someone And that was a big part of your daily life is a SA- cancer doctor. Yeah absolutely I mean I think the many people who are devastated by silence and cannot tolerate it Have to be distracted by all sorts of devices or general Things in life find that once they learn how to appreciate it. It's silences responsiveness. We can listen to things behind the clamor of the world. I want to try something a little bit strange at the end of this conversation but before he don't WanNa let you close and and talk about If you have much optimism and you've seen a lot of suffering and a lot of joy you write about this book in a Beautiful Way There's some despair at the state of things which I think listeners have heard in our conversation. Are you optimistic about the future? Do you think Think there's hope for a better approach to to these challenges. I almost feel like life nets that the world is the best of all possible worlds because I do feel very optimistic. I think that's Voltaire. Does I think that's Voltaire's is candidate is is it also live? Does he say that too? So all tare rotate Candied as a parody of life. Okay he made fun of life since he was poking fun at okay absolutely doctor. Pangloss is in candied. That's who live. Knits is supposed to be because doctor pangloss forever declaring in canty that always the best of all possible worlds but noses dare because the spectacle had to rest on it. Yeah that's So I but at the risk of sounding like lions I do think that the technology's super bright dolorous I mean I could not have imagined Twenty years ago that I would be living in a world when I go back to Karachi and I'm caught in a traffic jam and when you're caught in traffic German in Karachi at the red light often the homeless people and beggars will start knocking at your door. This started happening to me recently but in Karachi beggar started knocking on the door and before I could bring the window down. His cell phone rang and the onset the cell phone and look very concerned so when he got off the phone I said is everything. Okay now I got worried about it. And he said no no. Everything is fine. That was my wife on the cell phone telling me that there's a bigger traffic jam near the universe. She's telling me to take and Lubar to get there. Technology has such Bala to transform entire daily. Lives I mean been new asked me or commented earlier on that survey difficult insurmountable almost problem. I beg to differ with you on that now because I think that the paradigm shift overnight like it did from typewriter to a word processor from having a telephone boots to make calls to even homeless Beggars in the most impoverished countries in the world having access to the To to computers whose GAVIR carrying in their hands with powers that were unimaginable. Just two years ago so all. I'm saying is instead of going after the last cancer cell all the time yes. We should continue doing that for our current patients but at the same time. Let's turn to the first settled. Let's set the new goal. Let's incentivize the school financially and let the race begin and then what we have seen can happen. Is that the human genome acquired collaboration and competition simultaneously between hundreds of thousands of investigators. But then what? Twenty years ago took fifteen years to do to sequence the first genome and cost over a billion dollars. Today can be done in a few weeks for the cost of a few hundred dollars. This is where technology can transform. Everything within a decade is. What I'm saying and at the RE technology's moving it will be faster and faster going ahead. I'm fairly optimistic for the future of cancer. I WANNA close said trending a little bit different. I want to close with a Actually GonNa sing something which Lata character. I don't know if I've ever Sung entirely Sung something on this program before but There's a paradox in your book which is is. I've made it clear I think there's there's a lot of Despair and sadness in the book and yet there's an immense amount of joy and you've really all the patients who many of them Who passed away the one who passed away our immortal because they're in your book. Their song is is out there. answer really Credible thing one of the things that you're forced me to think about is The preciousness of life. And how somehow how is it possible that we have this great gift? We know it's finite we don't like to think about that. It's fine but we don't. It's our great tragedy and our great knowledge are great insight. We we go through life knowing it won't last forever and we think about it often as if it does which allows us to get annoyed at traffic jams and home repairs that don't work and all the petty disagreements we have with the people we love and It's strange that we can go through life that way for not careful While we all go through it to some extent that way so when I was thinking about that.

Karachi Voltaire cancer Museum of Modern Art RE technology Ezra Harvey Marina Brahma Veg Lata Brooke Russ Pangloss Ryan Lubar canty Simon Bala Garfunkel
"plastic syndrome" Discussed on Science for the People

Science for the People

06:20 min | 1 year ago

"plastic syndrome" Discussed on Science for the People

"When it's paid by insurance I mean I I have. I'm not personally a an American or live in the US. But I do have some friends in the US who I know forego preventive medicine or visiting a doctor until until they absolutely have to because of the way the health care system is in the US. I'm curious how much you think. This is a potential artifact of the expensive insurance system in the US and the way that's been set up and if that if that has any any influence on why we still kind of hyper focus in a bit on treating late stage or going to a doctor so late. I don't think so to Schilling. You have to be very honest. I think that the American system is still the very best system in the world and we are the leaders in the field and most areas in cancer research also and The reason that we can treat End Stage patients because we are affluent enough and can't afford it but not for long That's what I'm saying. So it is still the best system and the whole world looks to America for leadership. Where is our leadership? Now if we are going to develop therapies like car T. therapy that costs million dollars per patient. Which is good for a few thousand patients. Compared to one point seven million diagnosed in a year then the whole healthcare system will become Bankrupt and is on the verge of COLLAPSE HAVING TO SUPPORT FUEL. These expensive therapies. So right now. That's what's happening. I'm asking for a padded. I'm shift at least for the future. Let us imagine an invasion of better future. You know a lot of my colleagues will point. this thing to me and say ass be are all looking at the same thing but we are looking at the glass half full and you're looking at the class of fifty. I don't agree with that or shell because I'm looking at the whole loss. I want to see all of cancer treatment. I am not denying all advances. I'm not denying that we have cured. Sixteen puts in Beijing. I'm asking how can we do better? That's all very simple. Not JUST FOR THE THIRTY. Two percent were dying terrible debts but also the sixty eight percent were being cured. How can we do better by them? Also won in two minutes. One in three women will get cancer and in today's statistics. Why do we have to either receive slash boys and burn to live or die? A terrible death with with useless therapies. Can you talk a little bit about your MD s and am l. tissue repository and some of the challenges? You've had around getting funding to pursue research with this repository. That is a question that is really close to my heart. So back in Nineteen eighty-four When I decided to study really Yukimi online or dysplasia syndrome being an immigrant has helped me because had I gone to school in this country. My next step would have been to make a mouse model for studying mildest plastic syndrome but coming from Pakistan I depended on in instinct rather than on custom and tradition and my instinct. Mean that if I want to study this disease I should have sense from the patients I started. Banking sends back in nineteen eighty four today the tissue repository that. I have Houses over sixteen thousand samples from thousands of patients with MD as we have progressed in their disease and either gone and died of MDA's or are still living or have evolved into acute myeloid leukemia. B-samples are extremely precious. Because they trace the natural history of participants from pre-leukemic staged Wikipedia or pre-leukemic stage to a stage where it becomes viciously Malignant and kills the patient. We have cereal samples on them on the other hand. We have all the technology that has evolved whether we want to look for rare cells by using technologies of off Liquid biopsies by looking at a whole tube of blood and finding one abnormal malignant cell through. We're working with the pasture institute. Professor Patrizia Petrolini To find this kind of circulating tumor cell then we can also look at Oddity Dini proteins. We can look at metabolites biomarkers. We have all kinds of samples stored so that technology has beaten aboard. The tissue is available. Resources are what is needed. Resources to apply all the latest technology to so many compartments and to study them at all simultaneously in a few thousand patients and then subject the data to machine learning and artificial intelligence for analysis. And come up with the biomarkers the signatures. The combinations of tests that are needed to find the earliest footprint of cancer. It's all there. This can be accomplished fatty rapidly within a period of a couple of two to five years if we put our resources in this area and the idea That I began with is. Is the idea still have bitches once? We know the earliest markers of preview P me and then we can ask the question. Why did some healthy individuals get spree? Kimia? Even what made them susceptible. There's some genetic inheritance they had or was there some exposure or some Abnormal protein or micro environment that was abnormal in their bone marrow. Once we have that I that recognize which is which is going to definitely emerge from these kinds of studies. Then we can identify healthy individuals. Tired of getting really. And then you see me. And that's how we work our way back.

cancer US Schilling Beijing MD America Professor Patrizia Petrolini Pakistan pasture institute Wikipedia P MDA
"plastic syndrome" Discussed on 77WABC Radio

77WABC Radio

06:48 min | 1 year ago

"plastic syndrome" Discussed on 77WABC Radio

"To win two choices for free informative booklet and DVD Hey doctor leader men were back backordered but the eighty seven year old man he's a very as eight daughters who was born in Iran came here years decades ago as a daughter and grandson they came with a minute aid and he went to the big hospitals you have amassed his abdomen. scam he had a biopsy. he was found to have me as of the moment is abdomen. and the also the high PSA and the pipes the prostitute Greece of nine cancer. he had called us could be and the colonoscopy show polyps nothing more but he went to the hospital not for those reasons not for the cancer he went because he had difficulty walking for the last few months is that difficulty walking and speaking he's losing his voice is hoarse. his heart you can't speak and he wants to be helped and you went to a super duper big hospital number one of these are the most prestigious places in town and they were able to help with the went to another super duper big hospital they sent him home to well you know what they said a mom to do and that's not a very good thing and he came to us with what was most likely was called apparently a plastic syndrome some people with cancer have the cancer but the cancer's making no humor or substance that's harming the body and its believe this man that he has apparently a plastic syndrome he has a cancer is producing a substance harming as bodies we can't Walker speak. and he came to us that I examined him I went through his records and rather than something my home to die which is what the other place is dead we offer treatment to treat the massive muse of the though ms abdomen and his prostate try to get him back where it was a couple months ago we know that with new plastic syndrome that if you treat the cancer you can most likely get rid of the bad side effects of this parody of plastic syndrome so we offered treatment both of the music the the Allman the abdomen and to the height Gleason score prostate cancer. the intent and the purposes of course to try to control the cancer which is a good thing and also to get rid of this parody of plastic syndrome which is harming his life so terribly being unable to walk and unable to speak normally and this is the work that we do every day. and I want to speak about a forty year old woman from the Caribbean also she's married with one son he was diagnosed two years ago the right breast cancer one of the biggest super pooper hospitals he had a biopsy should a pet scanner doctors want to give her chemo she refuse and she transferred to another hospital. where should standard keymod standard radiation to the breast and then she had chemotherapy for a couple months then went to another hospital and no treatment then she lost her insurance of the gap and then she went to another hospital one of the biggest ones in New York City and she was offered more chemo which hasn't taken while the cancer is growing and it's growing extensively she has a mass in the breast of mass and the sponsors a lump of the breast her breast is massive filled with cancer right press that is again my fist is about eight centimeters have big hands big feet her mass of the breast is eight eighteen centimeters a mass of cancer this is a small woman probably I don't know size six or eight dress big woman with this massive cancer in the breast she said bleeding from the breast she is paying his distortion of the breast had a cat scan a week before she came to me at that other place and they showed progress of cancer. cancer's estrogen receptor project receptor her positivist receptor produce receptor negative. so I sars she's on pain medicines for this pain from the breast oxy code own Tyler alone get repenting and examined her. and she has this massive distortion of the breast total breast is gone there's modules growing through the prestige leading to rock hard Mart mass oppresses immovable left breast another hand is totally normal so she came we stage drop we got scans of her body and head and she has multiple brain metastases which were treating and of course she wants is to treat the breast also that's the work that we do every day every day for patients who have. the need we're here to treat the need. and I want to talk about a woman with another breast cancer does a woman who is forty nine years old born in New York City Meredith one child her sister came with her from Belgium. and this woman has a left breast cancer the patient detected it should a biopsy in the press you sound of a poor the different should carcinoma and she was scheduled to get testing of this woman who was diagnosed about five months ago. and she's being the value it one of the biggest hospitals in five months they haven't completed the staging which here we probably do in a day or two. so should a mammogram it was by red five hi this is vicious mass in the breast should alter some of the breast to five centimeter mass of the breast of multiple modules on their arm pit should an MRI in the pelvis photos of very in mass and that was in the five months ago nothing was done about that she never even got sick on the caller just about that the biopsy the brochure to poorly differentiated carcinoma of the breast with a high grade it was estrogen receptor negative for just receptor negative her weight is under sixty two pounds I examined her. and she has the seven centimeter mass of the left breast of multiple lymph nodes involved her lungs are fine the rest of her body and physical but the big mass in the left breast and multiple the floats vote so we got our staged up with an MRI scan and now she's deciding where she wants to go to treatment this is the work that we do every day we talked about the surgery on the breast you talked about no surgery talked about chemo talked about no chemo we talked about. read our treatment and we talked about all.

five months eight eighteen centimeters eight centimeters eighty seven year forty nine years seven centimeter sixty two pounds five centimeter forty year two years
"plastic syndrome" Discussed on No End In Sight

No End In Sight

12:40 min | 1 year ago

"plastic syndrome" Discussed on No End In Sight

"Rectum. I hope that's not too graphic. Anyone that's listening to worry on the table life so when she turned her fingers down to my rectum press they're almost i flew off the table and sound like it's not i knew that it wasn't my you know reproductive system and no i knew that it was my my my digestive system and plus. I mean i'm i don't normally look six months pregnant lady so anyway i was discharged home they did do i think they did the ultrasound and there was like an ovarian cyst. He'll spine relatively. Have we call him to people. I've had been rupture before and all that this back pain. This was different. I knew this was not so went home and then i i don don me. I'm like at that time. I actually didn't think actually. I wasn't sure that was a registered ngo de mytek. I was nash sure so but then once i went home like oh. You're in syria. Angela team again right. I call my allergist and exam like you have. We need samples up. There's a rescue mad for hereditary joe mccarthy rosier was sort of like epi for hereditary joe dina because does epi typically does not work on patients with hereditary ngo dima which is interesting because it's a different mechanism that causes swelling so gotcha auto it has to intervene somewhere else right yeah exactly so god a medical professional well good if you understand that that means everyone else who is not a medical alchol and so because sometimes i have to remember like sure everyone else can understand just your professionals. It's like funny within chronic illness patients because so many people have had so many medical experiences that most people have a more sophisticated language then mike near the general population but certainly not at not at the level probably of someone who has been through some kind of a program not at the level of my exactly. It's like to be really specific so it's like whoever it is all of the medical terminology relating to dare there there but it doesn't obviously apply to everything <hes> was. I gonna say oh so before you got discharged. You said you weren't sure you're and and they had tried some stuff but basically they just weren't able to get it under control. This was actually in the e._r. So i had gone to the e._r. A couple of days before before i got it made it okay. That's when i started having like the pain the difficulty all that show right. That's when i wasn't sure at dawn on me until i was back home than they stand on like wait. The minutes are caught. My allergies like the fears and he's like no me samples in the office. At this time i have my own butch clifton force on like so he's like oh come in so i go in. He gives me all this not all this but i think like two or three pages of literature along with orders to take back to the e._r. committed so just going to give this an e._r. Doctor because what's interesting is i did mention to the e._r. Doctor before i was discharged. I said i as you have a history of hereditary dima but she looked like i had about five hits. Yes not even yeah just went way over her head. She aegis is okay so i just let go like okay but then the next day was when i talk to my allergist and he gave me everything i needed so i went back to e._r. They admitted me they did treat me with fresh implies. I was in the hospital. I think think sixteen days over two weeks so it was a long time and we've tried the fresh frozen. Plasma just wasn't working. I don't know what was happening and i wasn't eating solids on the clearly quick break right all this nightmare and then <hes> i found that there is a hereditary angela dima center right in san diego california which is a two hour drive from wireless sound like well. How should make an appointment there so i can leave like see is is really what's going on but again in the back of my mind. I'm still like this doesn't explain everything. Explain these bazaar swelling episodes. I'm i'm having with anything else so i'm going to that appointment and basically that specialist was lie. I'm not sure like you might have hereditary ngo the type unknown which is kind of like a rare but you know i'm. I'm really looking at him like well along with my family history. I wouldn't be surprised atypical yeah okay so anyway. <hes> i ahead also made an appointment in march for august because with dr chia john chia is a special listen the emmy community doctors but he had like a five months way at that time made an appointment. I wasn't going to see him to august however ironically on the same day as my appointment in san diego. I got a call from his office. They had a cancellation for that afternoon. If we can make it we did make it that was nine months into my illness and on international awareness day and that's the day that i got my diagnosis. Whoa very ironic. That's a big day yeah and did you before the diagnosis. Had you started to learn about emmy if you're looking at that dr where you kind of going i think this might be it. I'm learning more about it or was kind of an accident to be very honest. While i was doing research my sisters were also doing research. I mean we you gotta come up with all other different kinds of diagnose that we tried and ruled out and then there in just crazy how the universe works so both of my sisters sent me links about emmy separately and they didn't even know that they had sent it to me like it was crazy. I'm almost at the same time so when i clicked beliefs and i'm i'm looking. I'm like oh my god. This sounds like me so so it was at that point that i made the appointment with dr chia but again tabby variability for like five months out so right in the meantime he has you do blood work before your appointment and one show blood work is complete than you are quote unquote eligible offer an earlier appointment. If there's a cancellation gotcha so that's how i was able to get him but it's just so ironic that my diagnosis would come on the day yeah ashley amy when it's uh when i wasn't even supposed to see him for three more months just like wow what crazy yeah how does that how crazy so go go ahead. I was just gonna say an woods. He covered by insurance just because you were talking about referrals and stuff before so what one thing that incident was nice nice with my particular age and i think most are like this but i can't speak for certain because that would be that'd be reckless when my h._m._o. Because is i had already seen and infectious disease specialists within my medical pool. I told you it was terrible. No <hes> i was able to request a second opinion outside of my medical gotcha and so you you could basically pretty much anywhere. I guess within reason anywhere i guess that my primary my insurance was anthem blue cross so wherever for a doctor to anthem blue cross i requested a second opinion and it wouldn't have to be approved through my medical group. It would just be anthem saying yes. You can get a second opinion at the soccer so my initial initial consultation with him was was no charge was just had to pay a co pay right and which would be expected anyway right yeah. That's normal no matter what unfortunately talk away so i did do that and then you know about the diagnosis day yeah a crazy and then <hes> i forgot to mention to along the way i even saw an ear nose and throat specialist because that the hoarseness in my voice ace lasted for a long time i can't remember how many months into the onus for a long time and what i learned as i have been sick longer is is that on days that i'm feeling worse. My voice tells the story so people who talked to me all the time if they call me and i'm having like you know one of my worst days <hes> they can tell right away. They're like oh. You don't sound rating hunger so it's interesting how my voice was is telling the story all along. I just didn't know but right like i said i saw your nose throat specialists and he was thinking like that there was so i do have local core paralysis on the right side that i've had for her. We've known about it at least ten years so but it's my core is paralyzed in the middle. Okay it allows me to still have a normal sounding non horse voice <hes> so well. It's because some doctors like oh your voices horse because you have the paralyzed car. I'm like no actually my voices. The normal paralyze core. That's not the problem so yeah that predates we date yeah the e._n._t. Who knew me well. He lomb was thinking that there was for about what he said. What else was long. There was us something but it wasn't explained. It still unexplained the systemic problems that i was having <hes> i still continue to see specialists even after dr chia just to make sure that there wasn't something else going on because oftentimes as you know what i mean have other illnesses going on there there was there was really that's true too yeah so i was found to have have something called para neo plastic syndrome and these abnormal labs again so for any foolish doctors that <music> beings. I'm pretty sure that i can't magically make my blood anyway plastic syndrome and basically sibley autoimmune odd onomic neuropathy okay <hes> so it's one of those illnesses that falls under the disorder nominee umbrella people a lot of people have like hots. Don't have pots that comes up all the time. I have a different thing. I don't mean not not mcnair rapidy with that <unk> neoplastic syndrome though i do so with that my automatic nervous system obviously doesn't function properly side issues with low blood pressure issues with low blood volume. I have <hes> i i give myself i._v. Hydration several times a week through my pores that i have in my chest i have you know if i stand up fast. Everything goes black young no that one. I've been fortunate to be always somewhere. I could buy and hold the wall or something so i don't hit the floor but still yeah i learned to fight and being very cautious about letting my feet dangling before i stand just to try to avoid <hes> collapsing when you're on the floor i also have quite a bit of difficulty with showering a- <hes> i'm not able to shower every day i am when i am able to shower after us a shower chair yeah <hes> even being on the shower chair. My heart still races at about one hundred and fifty beats per minute watch for people who are not in the medical field. <hes> adults aren't weight is sixty to one hundred beats per minute. You got his high so one fifty fifty at wrist because i'm in the shower sitting down. I'm not even standing so imagine. If i tried to stand up i would be on the shower floor. Collapsed passed out yeah <hes> and you think that's partly heat like that's part of it with showers right that is part of it because of the autonomic dysfunction. I don't tolerate..

dr chia john chia e._r san diego ngo de mytek ovarian cyst joe mccarthy rosier syria Angela soccer hoarseness california nash mike joe dina ashley amy neoplastic syndrome lomb mcnair
"plastic syndrome" Discussed on No End In Sight

No End In Sight

16:02 min | 1 year ago

"plastic syndrome" Discussed on No End In Sight

"Hi i'm brian bennett and this is no end in sight a podcast about life with chronic illness quick reminder that i recently started a patriot so that i can hire somebody buddy to help me catch up on transcripts. If you've been enjoying this show and you have a couple of bucks to spare then i'd be so grateful if you'd sign up as a patron at patriotair dot com slash no end in sight. I don't have any fun perks setup yet but as soon as i figure those out. I'll make sure that they go to all supporters today. I'm talking to ashanti daniel about emmy and this is a long list hereditary ngo dima an asthma and this is a hard one <hes> perennial a plastic syndrome that was just a word i'd never pronounced before and autoimmune autonomic neuropathy in my esteemed gravitas and masol activation syndrome. <hes> co morbidity are complicated as i'm sure you all know ashanti also worked as a nurse before getting sick so she's able to tell her entire story with that additional on on medical lines which is really interesting and informative before we start. Here's my disclaimer. This podcast is not intended as a substitute for professional medical medical advice diagnosis or treatment. Make sure you talk to your practitioner about any questions or symptoms. <hes> um.

ashanti activation syndrome autonomic neuropathy brian bennett emmy
"plastic syndrome" Discussed on 77WABC Radio

77WABC Radio

07:27 min | 1 year ago

"plastic syndrome" Discussed on 77WABC Radio

"About the eighty seven year old man he's a very as eight daughters who was born in Iran came here years decades ago as a daughter and grandson they came with a minute eight and he went to the big hospitals you have amassed his abdomen scam he had a biopsy he was found to have me as of the moment is abdomen and the also the high PSA and the pipes the prostitute Gleason nine cancer you could call us could be and the colonoscopy show polyps nothing more but he went to the hospital not for those reasons not for the cancer he went because he had difficulty walking for the last few months is that difficulty walking and speaking he's losing his voice is hoarse this is ours he can't speak and he wants to be helped and he went to is super duper big hospital number one of these are the most prestigious places in town and they were able to help with the went to another super duper big hospital they sent him home to well you know what there's a mom to do and that's not a very good thing and he came to us with what was most likely was called a parody of plastic syndrome some people with cancer have the cancer but the cancer's making no humor or substance that's harming the body and its believe this man that he has apparently a plastic syndrome he has a cancer is producing a substance harming as bodies we can't walkers speak and he came to us that I examined him I went through his records and rather than sending home to die which is what the other places that we offer treatment to treat the massive muse of the though ms abdomen and his prostate turning get going back where it was a couple months ago we know that with new plastic syndrome that if you treat the cancer you can most likely get rid of the bad side effects of this parody of plastic syndrome so we offered treatment both of the music theory Allman the abdomen and to the height Gleason score prostate cancer the intent and the purposes of course to try to control the cancer which is a good thing and also to get rid of this parody of plastic syndrome which is harming his life so terribly being unable to walk and unable to speak normally and this is the work that we do every day and I want to speak about a forty year old woman from the Caribbean also she's married with one son he was diagnosed two years ago the right breast cancer one of the biggest super pooper hospitals had a biopsy should a pet scanner doctors want to give her chemo she refused and she transferred to another hospital where should standard keymod standard radiation to the breast and then she had chemotherapy for a couple months and went to another hospital and no treatment then she lost her insurance at the gap and then she went to another hospital one of the biggest ones in New York City and she was offered more chemo which she hasn't taken while the cancer is growing and it's growing extensively she has a mass in the breast of mass and the sponsors a lump of the breast her breast is massive filled with cancer right press that is again my fist is about eight centimeters have big hands big feet hurt mass in the breast is eight eighteen centimeters a mass of cancer this is a small woman probably I don't know size six or eight dress big woman with this massive cancer of the breast she said bleeding from the breast chest pain she is the source of the breast he had a cat scan a week before she came to me at that other place and they showed progress of cancer cancer's estrogen receptor project receptor her positivist receptor produce receptor negative so I sars use on pain medicines for this pain from the breast oxy code own Tyler alone get repenting and examined her and she has this massive distortion of the breast total breast is gone there's modules growing through the press is leading to rock hard my master presses immovable left breast another hand is totally normal so she came we staged her up we got scans of her body and head and she has moldable brain metastases which retreating and of course she wants is to treat the breast also that's the work that we do every day every day for patients who have the need we're here to treat the need and they want to talk about the woman with another breast cancer does a woman who is forty nine years old born in New York City Meredith one child her sister came with her from Belgium and this woman has a left breast cancer the patient detected that ship a biopsy in the press you sound of a poor the different should carcinoma and she was scheduled to get testing of this woman who was diagnosed about five months ago and she's being the value it one of the biggest hospitals in five months they haven't completed the staging which here would probably do in a day or two so should a mammogram it was by red five hi this is vicious mass in the breast should alter some of the breast of five centimeter mass of the breast of multiple modules on their arm pit should an MRI in the pelvis photos of very en masse and that was in the five months ago nothing was done about that she never even got sick on the caller just about that the biopsy the brochure to poorly differentiated carcinoma of the breast with a high grade it was estrogen receptor negative for just receptor negative her weight is under sixty two pounds examined her and she has the seven centimeter mass of the left breast of multiple lymph nodes involved her lungs are fine the rest of her body and physical for the big mass in the left breast and multiple then flows vote so we got our stage stop with an MRI scan and now she's deciding where she wants to get our treatment this is the work that we do every day we talked about the surgery on the breast we talked about no surgery we talked about chemo talked about no chemo we talked about Ron our treatment and we talked about all the options and she's now deciding how she wants to be treated but I can tell you that most women that come here save their breast when I came to New York ninety seven percent of women with breast cancer the big hospitals were losing their breast here the same time ninety percent of women were saving their breast the breast cancer is the same the women the same the only difference is the mentality of the doctors here it registered in your doctor liederman group versus the big hospitals were surgeons often have a dominant or domineering role and we often see women with small tumors were told they have to have mastectomies well we know for most women there are treatment options and we.

Iran five months eight eighteen centimeters ninety seven percent eight centimeters eighty seven year forty nine years seven centimeter sixty two pounds five centimeter ninety percent forty year two years
"plastic syndrome" Discussed on 77WABC Radio

77WABC Radio

06:41 min | 1 year ago

"plastic syndrome" Discussed on 77WABC Radio

"With the eighty seven year old man he's a very as eight daughters who was born in Iran came here years decades ago as a daughter and grandson they came with a minute eight and he went to the big hospitals you had amassed his abdomen scam he had a biopsy he was found to have me as of the moment is abdomen and the also the high PSA and the pipes the prostitute Gleason nine cancer you could call us could be and the colonoscopy showed polyps nothing more but he went to the hospital not for those reasons not for the cancer he went because he had difficulty walking for the last few months is that difficulty walking and speaking he's losing his voice is hoarse his heart she can't speak and he wants to be helped and he went to is super duper big hospital number one of these are the most prestigious places in town and they were able to help with the went to another super duper big hospital they sent him home to well you know what they said a mom to do and that's not a very good thing and he came to us with what was most likely was called a parody of plastic syndrome some people with cancer have the cancer but the cancer's making no humor or substance that's harming the body and its believe this man that he has apparently a plastic syndrome he has a cancers producing a substance harming as bodies we can't Walker speak and he came to us and I examined him I went through his records and rather than sending home to die which is what the other places that we offer treatment to treat the mass of muse of the the home is abdomen and his prostate try to get him back where it was a couple months ago we know that with new plastic syndrome that if you treat the cancer you can most likely get rid of the bad side effects of this parody of plastic syndrome so we offered treatment both of the music the the Allman the abdomen and to the height Gleason score prostate cancer the intent and the purposes of course to try to control the cancer which is a good thing and also to get rid of this parody of plastic syndrome which is harming his life so terribly being unable to walk and unable to speak normally and this is the work that we do every day and I want to speak about a forty year old woman from the Caribbean also she's married with one son he was diagnosed two years ago the right breast cancer one of the biggest super pooper hospitals he had a biopsy showed a pet scanner doctors want to give her chemo she refused and she transferred to another hospital where should standard keymod standard radiation to the breast and then she had chemotherapy for a couple months then went to another hospital and no treatment then she lost her insurance of the gap and then she went to another hospital one of the biggest ones in New York City and she was offered more chemo which she hasn't taken while the cancer is growing and it's growing extensively she has a mass in the breast of mass of the sponsors a lump of the breast her breast is massive filled with cancer right press that is again my fist is about eight centimeters have big hands big feet her mass of the breast is eight eighteen centimeters a mass of cancer this is a small woman probably I don't know size six or eight dress big woman with this massive cancer in the breast she said bleeding from the breast his pain his distortion of the breast had a cat scan a week before she came to me at that other place and they showed progress of cancer cancer's estrogen receptor project receptor her positivist receptor produce receptor negative so I sars shoes on pain medicines for this pain from the breast oxy code own tile alone get repenting and examined her and she has this massive distortion of the breast total breast is gone there's modules growing through the press is leading to rock hard Mart mass oppresses immovable left breast another hand is totally normal so she came we stage drop we got scans of her body and head and she has multiple brain metastases which retreating and of course she wants is to treat the breast also that's the work that we do every day every day for patients who have the need we're here to treat the need and they want to talk about the woman with another breast cancer does a woman who is forty nine years old born in New York City Meredith one child her sister came with her from Belgium and this woman has a left breast cancer the patient detected it should a biopsy the pressures from the report of the different should carcinoma and she was scheduled to get testing of this woman who was diagnosed about five months ago and she's being the value it one of the biggest hospitals in five months they haven't completed the staging which here would probably do in a day or two so should a mammogram it was by red five hi this is vicious mass in the breast should alter some of the breast of five centimeter mass of the breast of multiple modules on their arm pit should MRI in the pelvis photos of very in mass and that was in the five months ago nothing was done about that she never even got sick on the caller just about that the biopsy the brochure to poorly differentiated carcinoma of the breast with a high grade it was estrogen receptor negative for just receptor negative her weight is a hundred sixty two pounds I examined her and she has this seven centimeter mass of the left breast of multiple lymph nodes involved her lungs are fine the rest of her body and physical but the big mass in the left breast and multiple the floats vote so we got our staged up with an MRI scan and now she's deciding where she wants to get our treatment this is the work that we do every day we talked about the surgery on the breast we talked about no surgery we talked about chemo we talked about no chemo talked about read our treatment and we talked about.

Iran five months eight eighteen centimeters hundred sixty two pounds eight centimeters eighty seven year forty nine years seven centimeter five centimeter forty year two years
"plastic syndrome" Discussed on 77WABC Radio

77WABC Radio

07:30 min | 1 year ago

"plastic syndrome" Discussed on 77WABC Radio

"Choices for free informative booklet and DVD Hey doctor leader men were back back order but the eighty seven year old man he's a very as eight daughters who was born in Iran came here years decades ago is a daughter and grandson they came with a minute eight and he went to the big hospitals you have amassed his abdomen scam he had a biopsy he was found to have me as of the moment is abdomen and the also the high PSA and the pipes the prostitute Gleason nine cancer you could call us could be and the colonoscopy showed polyps nothing more but he went to the hospital not for those reasons not for the cancer he went because he had difficulty walking for the last few months is that difficulty walking and speaking he's losing his voice is hoarse this is ours you can't speak and he wants to be helped and he went to is super duper big hospital number one of these are the most prestigious places in town and they were able to help with the went to another super duper big hospital they sent him home to well you know what they said a mom to do and that's not a very good thing and he came to us with what was most likely was called a parody of plastic syndrome some people with cancer have the cancer but the cancer's making no humor or substance that's harming the body and its believe this man that he has apparently a plastic syndrome yes the cancers producing a substance harming as bodies we can't Walker speak and he came to us and examined him I went through his records and rather than selling my home to die which is what the other place is dead we offer treatment to treat the massive muse of the the home is abdomen and his prostate try and get going back where it was a couple months ago we know that with new plastic syndrome that if you treat the cancer you can most likely get rid of the bad side effects of this parody of plastic syndrome so we offered treatment both of the music to the Allman the abdomen and to the hi Gleason score prostate cancer the intent and the purposes of course to try to control the cancer which is a good thing and also to get rid of this parody of plastics and room which is harming his life so terribly being unable to walk and unable to speak normally and this is the work that we do every day and I want to speak about a forty year old woman from the Caribbean also she's Meredith one son he was diagnosed two years ago the right breast cancer one of the biggest super pooper hospitals he had a biopsy should a pet scanner doctors want to give her chemo she refused and she transferred to another hospital where should standard keymod standard radiation to the breast and then she had chemotherapy for a couple months then went to another hospital and no treatment then she lost her insurance of the gap and then she went to another hospital one of the biggest ones in New York City and she was offered more chemo which hasn't taken while the cancer is growing and it's growing extensively she has a mass in the breast of mass of the sponsors a lump of the pressed her breast is massive filled with cancer right press that is again my fist is about eight centimeters have big hands big feet her mass of the breast is eight eighteen centimeters a mass of cancer this is a small woman probably I don't know size six or eight dress big woman with this massive cancer in the breast she said bleeding from the breast this page is the source of the breast he had a cat scan a week before she came to me at that other place and they showed progress of cancer cancer's estrogen receptor project receptor her positives receptor produce receptor negative so I sars shoes on pain medicines for this pain from the breast oxy code own Tyler alone Gabba Penton and examined her and she has this massive distortion of the breast total breast is gone there's modules growing through the prestige leading to rock hard Mart mass the presses a movable left breast another hand is totally normal so she came we stage drop we got scans of her body and head and she has moldable brain metastases which were treating and of course she wants is to treat the breast also that's the work that we do every day every day for patients who have the need we're here to treat the need and they want to talk about the woman with another breast cancer is a woman who is forty nine years old born in New York City Meredith one child her sister came with her from Belgium and this woman has a left breast cancer the patient detected that should a biopsy in the press you sound of a poor the different should carcinoma and she was scheduled to get testing of this woman who was diagnosed about five months ago and she's being the value it one of the biggest hospitals in five months they haven't completed the staging which here would probably do in a day or two so should a mammogram it was by red five hi this is vicious mass of the breast should alter some of the breast of five centimeter mass of the breast of multiple modules on the arm pit should an MRI in the pelvis photos of very in mass and that was in the five months ago nothing was done about that she never even got sick on the caller just about that the biopsy the brush showed a poorly differentiated carcinoma of the breast with a high grade it was estrogen receptor negative for just receptor negative her weight is under sixty two pounds I examined her and she has this seven centimeter mass of the left breast of multiple lymph nodes involved her lungs are fine the rest of her body and physical but the big mass in the left breast and multiple then flows vote so we got our staged up with an MRI scan and now she's deciding where she wants to get our treatment this is the work that we do every day we talked about the surgery on the breast you talked about no surgery talked about chemo talked about no chemo we talked about Ron our treatment and we talked about all the options and she is now deciding how she wants to be treated but I can tell you that for most women that come here save their breast when I came to New York ninety seven percent of women with breast cancer the big hospitals were losing their breast here the same time ninety percent of women were saving their breast the breast cancer is the same the women the same the only difference is the mentality of the doctors here it registered in New York doctor liederman group versus the big hospitals were surgeons often have a dominant or domineering role and we often see women with small tumors were told they have to have mastectomies well we know for most women.

five months eight eighteen centimeters ninety seven percent eight centimeters eighty seven year forty nine years seven centimeter sixty two pounds five centimeter ninety percent forty year two years
"plastic syndrome" Discussed on 77WABC Radio

77WABC Radio

07:30 min | 2 years ago

"plastic syndrome" Discussed on 77WABC Radio

"Free informative booklet and DVD Hey doctor leader men were back back talk about the eighty seven year old man he's a very as eight daughters who was born in Iran came here years decades ago is a daughter and grandson they came with a minute eight and he went to the big hospitals you had amassed his abdomen scam he had a biopsy he was found to have me as of the moment is abdomen and the also the high PSA and the pipes the prostitute Gleason nine cancer you could call us could be and the colonoscopy show polyps nothing more but he went to the hospital not for those reasons not for the cancer he went because he had difficulty walking for the last few months is that difficulty walking and speaking he's losing his voice is hoarse this is ours you can't speak and he wants to be helped and he went to is super duper big hospital number one of these are the most prestigious places in town and they were able to help with the went to another super duper big hospital they sent him home to well you know what they said a mom to do and that's not a very good thing and he came to us with what was most likely was called a parody of plastic syndrome some people with cancer have the cancer but the cancer's making no humor or substance that's harming the body and its believe this man that he has apparently a plastic syndrome he has a cancer is producing a substance harming as bodies we can't Walker speak and he came to us that I examined him I went through his records and rather than selling my home to die which is what the other places that we offer treatment to treat the massive maze of the the open his abdomen and his prostate try to get him back where it was a couple months ago we know that with new plastic syndrome that if you treat the cancer you can most likely get rid of the bad side effects of this parody of plastic syndrome so we offered treatment both of the music do the Allman the abdomen and to the height Gleason score prostate cancer the intent and the purposes of course to try to control the cancer which is a good thing and also to get rid of this parody of plastic syndrome which is harming his life so terribly being unable to walk and unable to speak normally and this is the work that we do every day and I want to speak about a forty year old woman from the Caribbean also she's married with one son he was diagnosed two years ago the right breast cancer one of the biggest super pooper hospitals he had a biopsy should a pet scanner doctors want to give her chemo she refused and she transferred to another hospital where should standard chemo and standard radiation to the breast and then she had chemotherapy for a couple months then went to another hospital and no treatment then she lost her insurance of the gap and then she went to another hospital one of the biggest ones in New York City and she was offered more chemo which hasn't taken while the cancers grow in and it's growing extensively she has a mass in the breast of mass of the sponsors a lump of the breast her breast is massive filled with cancer right press that is again my fist is about eight centimeters have big hands big feet hurt mass in the breast is eight eighteen centimeters a mass of cancer this is a small woman probably I don't know size six or eight dress big woman with this massive cancer in the breast she said bleeding from the breast his pain his distortion of the breast he had a cat scan a week before she came to me at that other place and they showed progress of cancer cancer's estrogen receptor project receptor her positivist receptor produce receptor negative so I sars shoes on pain medicines for this pain from the breast oxy code own tile alone Gabba Penton and examined her and she has this massive distortion of the breast total breast is gone there's modules growing through the press is bleeding to rock hard Mart mass oppressed as immovable the left breast another hand is totally normal so she came we staged her up we got scans of her body and head and she has multiple brain metastases which were treating and of course she wants is to treat the breast also that's the work that we do every day every day for patients who have the need we're here to treat the need and they want to talk about the woman with another breast cancer does a woman who is forty nine years old born in New York City Meredith one child her sister came with her from Belgium and this woman has a left breast cancer the patient detected it should a biopsy in the press you son of a poorly different should carcinoma and she was scheduled to get testing of this woman who was diagnosed about five months ago and she's being the value it one of the biggest hospitals in five months they haven't completed the staging which here would probably do in a day or two so should a mammogram it was by red five hi this is vicious mass of the breast should alter some of the breast of five centimeter mass of the breast of multiple modules on their arm pit should an MRI in the pelvis photos of very in mass and that was in the five months ago nothing was done about that she never even got sick on the caller just about that the biopsy the breast showed a poorly differentiated carcinoma of the breast with a high grade it was estrogen receptor negative for just receptor negative her weight is a hundred sixty two pounds I examined her and she has this seven centimeter mass of the left breast of multiple lymph nodes involved her lungs are fine the rest of her body and physical but the big mass in the left breast and multiple then flows vote so we got our staged up with an MRI scan and now she's deciding where she wants to get our treatment this is the work that we do every day we talked about the surgery on the breast and talked about no surgery we talked about chemo talked about no chemo talked about Ron our treatment and we talked about all the options and she's now deciding how she wants to be treated but I can tell you that for most women that come here save their breast when I came to New York ninety seven percent of women with breast cancer the big hospitals were losing their breast here the same time ninety percent of women were saving their breast the breast cancer is the same the women the same the only difference is the mentality of the doctors here it registered in New York doctor Lieberman group versus the big hospitals were surgeons often have a dominant or domineering role and we often see women with small tumors were told they have to have mastectomies well we know for most women.

five months eight eighteen centimeters hundred sixty two pounds ninety seven percent eight centimeters eighty seven year forty nine years seven centimeter five centimeter ninety percent forty year two years
"plastic syndrome" Discussed on AFP: American Family Physician Podcast

AFP: American Family Physician Podcast

01:43 min | 2 years ago

"plastic syndrome" Discussed on AFP: American Family Physician Podcast

"Years old risk factors for our C, C R, hypertension, tobacco use obesity and acquired cystic kidney disease. In the setting of N stage renal disease, occupational exposure to trichloroethylene also increases the risk of an mortality from RCC, Geno. What is trichloroethylene? Good question, Jake. So it's an industrial solvent. People who work in mechanics drycleaners oil processors in polyvinyl chloride manufacturers have higher risk of exposure, gotta other risk factors include familial syndromes, such as von hippo Lindau disease, which can increase the risk of developing our CC screening for our C C is not recommended and less in the setting of a heritable syndrome. That increases the risk for our C C like that von hip Landau primary prevention is based on management of hypertension, and obesity and avoidance of tobacco more than fifty percent of patients with RC our ase him to Matic and diagnosed incidentally, during the Rocco abdominal imaging for unrelated issues, the triad of growth, he Materia flank pain and palpable. Abdominal mass that we all learned in medical school. All is uncommon and is a sign of advanced disease. Other symptoms include isolated right sided varicocele, bilateral lower extremity Dima or a perennial plastic syndrome of hypertension, hyper, Kelsey, Mia and polycythemia diagnosis depends on presenting symptom. If an isolated right sided or non-reducing, bilateral Erica seals present get domino. Imaging gercy materials should be evaluated with C T Uraga Agassi in urology consultation for stocks copy, he material on a urine dipstick requires microscopy to confirm that greater than three RBC's per high power field.

hypertension cystic kidney disease obesity Abdominal mass Uraga Agassi Jake RCC varicocele Matic flank pain Erica Dima polycythemia Landau RBC Rocco Kelsey RC Mia
"plastic syndrome" Discussed on Novel Targets

Novel Targets

03:39 min | 2 years ago

"plastic syndrome" Discussed on Novel Targets

"Is try. It's a try specific killer engage her, and we have made bikes and trikes to compete with the cars in a bike is very simply to single chain of fees that one side is targeted to the receptor CD sixteen. So it's an anti-seizure sixteen Agnes stick single Chena fee. The other side could be any tumor antigen. We've most explored entice CD thirty three and Anchin on AM L cells and my legit plastic syndrome. So, but we've also made this to f- Cam things that are on carcinomas. So the difference between the bike and the trunk is tha. Get to single chain of fees to be functional you have to have a link or so that they fall correctly in Khanin dependent -ly bind to the Casal to the tumor target to make an immunological logic synapse in when you make these bikes in engage CD sixteen hundred in Casals, they have no proliferative signal whatsoever. They do engage tumor killing, but they have no proliferative signals. So what we've done with the tricks is we've taken the inert Lincoln and replaced it with the fifteen sequence in. Now, we have antigen specificity because we have two single chain of fees, and we have an fifteen molecule to give you the proliferative signal to survival signal in our data shows in vitro in an animal models at this is gonna be I superior than the bikes which only do the engagement piece, but don't give the proliferative signal. Seventeen to Miller presented a post on a second generation trike. He's developed avenue antibody construct. The link has been modified to shorten immune sign ups between the K selling Chuma cell with the idea that this will enhance efficacy. I hope we'll his clinical data ash moving on T cells have to lot of interest to recent FDA approvals within the with idea of inserting American Jim receptive into t cell in order to target antigens CD nineteen. So can we put a car into an encase cell, and k cells can also be modified by antigen receptors, you can generate car, and k cells today, most of the work that's been done on car in case cells has been done either in cell lines or cells that have been differentiated from either Jimeta poetic or pluripotent stem cells that they provide important proof of concept that you can modify an case L genetically and redirected. It just like you would t cell to a specific tumor type. I think that's one of the ways that we're gonna see an K cells expand beyond human logic malignancies and have the potential to be targeted to solid tumors or many different cancer types. If you can get the N K sell to be activated. It can kill the most chemo resistant tumor known to man. And so, you know, there's gold in them hills. And so learning how to mind our lab, we've developed Carin case cells that we've published recognized and can treat effectively globe. Last doma. We've looked multiply Aloma. We have data in acute myeloid leukemia. So, you know, putting the car onto the case L seems to working taking each piece and starting to combine these developing and harnessing technology, I e we can affect case with lengthy fires retrovirus we can start to really create our own tools..

Miller Casals Agnes solid tumors Jimeta FDA Chuma Carin Jim N K
"plastic syndrome" Discussed on Bloomberg Radio New York

Bloomberg Radio New York

02:04 min | 3 years ago

"plastic syndrome" Discussed on Bloomberg Radio New York

"Years well it's part of one of the products that there were most revellers are derived from and what are we expect going for this business it's doing and thirteen billion a year in revenues and uh growing it is at a sixteen percent clip exactly gene um is if the company that it is very very fully start oncology and their main product is a product called rebel amid and and this is sort of um the the blessing in the curse for this company both at the same time and that it is the overwhelming majority uh all their sales um to treat uh i'll let you said because i don't know how to my alone leave the miley us plastic syndromes and and my idea is another subgroup but it closely myeloma fail but that really drive the blockbuster nature of this drug and it is the company has been uh in the process of diversifying beyond rebel but rebel made of just such a behemoth of a drug um you know i think it reminds a lot of people uh uh siser and let the torn just how much of a percentage of the company that wound up being um men rebel made continues to grow and continues to be a a breed earn greater percentage of tell them and and i think part of why um led to the talaeh last quarter uh one rebel amid looked great um but everything else was a little bit of a disappointment and and and rebel omitted the bluffing the cash cow right now um but at some point it is a small molecule it will go generic there's a lot of debate as to when exactly uh gin our countries will come to market and and they are engaged in a patent litigation with a number of a potential generic makers uh to try to keep rebel amid branded as long as possible um but the the street concerns the investor concerns are um whatever the number is nine billion ten billion twelve billion uh whenever it go hits that generic class classify they're going to have a really hard time kind of selling a gap not not only to grow um but even to recoup a lot of the cash flow that wind up nothing um from the disappearance of that drug.

main product miley cash flow sixteen percent