40 Burst results for "Pfizer"
Fresh update on "pfizer" discussed on World News Tonight with David Muir
"Really wendy. Manufacturing started our engineering runs. And we've been in constant productions from plants in louisville and memphis up to four million doses ready to ship out within days of getting the green light and one hundred million by the end of june. That's when the country could see enough vaccine for all american adults and by the end of july my dern and pfizer will deliver the last of their six hundred million doses which would mean a surplus. I use the defense production act to speed up the supply chain for key equipment. That's already helped increase vaccine production but today some health officials concerned about the variants noting the recent plunge in cases maybe stalling with an uptick in the last three days. Latest data suggests that these declines may be stalling. Potentially leveling off at still a very high number we had cdc consider this very concerning shift introductory still. The vaccinate is picking up steam. The one hundred first airborne division deployed to orlando to support vaccination efforts there and those shipments delayed by the storm now flowing in the northeast new york adding overnight shifts at mass vaccination sites after getting extra supply. Lot has now come in so we're going to blitz this week all of this very encouraging johnson with us now from a vaccination cited city field tonight and that unanimous vote late today from the fda event visory panel so walk us through. What's expected in the coming hours. How soon we could see shots and arms across the country with one shot vaccine david. Final authorisation from the fda is expected within the next twenty four hours. Then on sunday a cdc panel will meet to discuss prioritizing the deployment of this new vaccine. Those first shipments could go out as early as monday with.
J&J COVID-19 vaccine could get FDA approval within days
"The fda is getting ready to authorize a third covid vaccine emergency use in this country. This one this vaccine is from pharmaceutical giant. Johnson and johnson. And if it's authorized it would join vaccines from pfizer and madera in the us vaccination campaign. But here's the thing those other. Vaccines require two doses. This vaccine from johnson and johnson needs only one single dose to be effective. Npr science correspondent. Joe palca is here to tell us how effective good morning joe morning. well one dose. that's exciting. How good is this new vaccine. Oh it's good. It was sixty six percent effect of overall in preventing moderate to severe disease and eighty five percent protective against more severe diseases. Now for people with good memories. They'll say wait. A minute i heard that madonna and pfizer wasn't that closer to ninety five percent effective and the answer is yes they were higher but those vaccines were tested before. Some of the new variants began circulating and prevent any five percent of severe critical. Disease is really good since the goal of the vaccines is to keep people out of the hospital and keep them from dying and the other thing about this vaccine is mentioned in the intro is that it's one dose which makes the logistics of getting it to people a lot easier to remember to come back so public. Health officials are looking forward to being able to distribute the j. vaccine. This is how anthony fauci chief medical adviser to the president. Put it on. Nbc's today show to have them come in and be in the mix with the other. Two is is nothing but good news. Nothing but good news. Foul cheat now. The process usually is before a vaccine gets authorized in advisory board has to approve it right. Well yes well. Though he has to is probably an exaggeration. It doesn't absolutely has to. The fda can approve things on its own lookout but like the other two vaccines. The the fda wanted to be extremely transparent. There were some questions about whether they were rushing the vaccine to the market before they knew it was safe and they want to assure the public that this was being looked at carefully so that committee has been around for a while. it's known in the trade as burg. Pack the vaccines and related biological products. Advisory committee i love that name ver- pack made of scientists and doctors with a variety of specialization relating vaccines before the meeting. Fda provides the committee with its analysis and they also make that analysis of the public So i asked. Bruce gallon president of global immunization at sabin vaccine institute. What he made of the analysis of the johnson and johnson vaccine. I didn't see anything in it. That i would think is going to be a show stopper for packed. Wanna recommend that. Fda act on so gallon is predicting the ver- pack will give the vaccine a thumbs up. How many doses. Johnson and johnson have ready to ship out. Well not as many as people had hoped a year ago when started trying to make these vaccines they all said. All we're gonna do this at risk manufacturing which means we're going to start making vaccine before they even knew it was going to be authorized even if it worked. And then they'd throw away if it didn't work and the government gave the money to do this but even with that company's still don't have the kind of inventory. The country needs in the case of johnson. Johnson they have about four million doses ready to go out the door and expect to have twenty million by the end of march and one hundred million by the end of june and remember. This is a one dose vaccine so one hundred million doses is one hundred million people vaccinated which is very big. Deal leslie and briefly. What is the timeline here. When the fda issued the emergency use authorization it could be any minute. I mean they knew it right after the meeting. They could do it tomorrow. That could do it in a few days. It'll be soon. I think if the committee gives a thumbs
Fresh update on "pfizer" discussed on John and Ken on Demand
"When the people wrote the law they said well you know an emergency we shouldn't you know also be able to mandate things. If i wrote the law i would say an emergency you should be able to mandate things because it's an emergency right. What do you think of the variants. Because i see these scary news stories and we had a doctor on yesterday from the university. Uc san francisco dr gandhi and and she thought that that the variant scaring the media was wildly overblown. Where are you on that. I love monica. Gandhi she is a voice reason in a sea of craziness so No i mean she's she's absolutely right so i mean we need to monitor the variants. You know we were doing a lousy job of testing and tracking these various where we're eager to sell all this equipment. You know for for sequencing but we don't use it ourselves in the public health system but now they're investing to to do that so we need to track it. We need to monitor. But there's actually very little evidence that it may that the various make things worse and we're the variants were in brazil and south africa. They did the vaccine studies. And the vaccines worked. So i'm in agreement with dr gandhi. Who's a deer longtime colleague of mine. Johnson johnson vac vaccines likely to get approved for emergency. Use any minute now do you. Should people have a preference between the pfizer. Dern style vaccine and the johnson and johnson vaccine or doesn't it matter They should you know. Get whatever they can get The soonest obviously the johnson johnson vaccine has an advantage. Is you only have to get at once as the plo. As opposed to getting a booster dose at either three or four weeks but all three were equally one hundred percent protective against hospitalization and death. There was a a small signal that you know. Maybe the johnson and johnson in one of those study settings you know wasn't as effective at preventing mild or moderate disease. But those are you know fairly trivial concerns. They're all hundred percent effective at preventing hospitalization and death talented. This i mean we've had a huge drop in all of metrics in the last six weeks. You think this is going to hold. I think we have very good. You know You know very good wins you know. Tell winds pushing us forward. I think you know. Unfortunately thirty to fifty percent of the population in many parts of los angeles Got infected. And now we've gotten a vaccine out. Nearly fifty percent of people sixty five or older have been vaccinated. County has done a great job with.
FDA allows storage, transport of Pfizer vaccine at higher temperatures
"And Drug Administration will now allow shipments of visors Cove in 19 vaccine at Standard freezer temperatures until now, ultra cold temperatures from minus 76 degrees to minus 112 F or required for shipments and storage of the frozen Fizer vaccine vials. The FDA says it has reviewed new data from New York based Fizer and its German partner by on Tech based on the new information, The FDA says the Fizer vaccine cannot be transported and stored for up to two weeks at temperatures of freezers commonly found in pharmacies. Mike Rossi, a Washington
Fresh "Pfizer" from Tom and Curley
"We're not. While this vaccine holds promise, requiring just a single dose, The biggest issue may not be quality but quantity. The disappointment in the J and J vaccines is that there are only going to have three or four million doses available. Now. What numbers would you have? Expected to have seen I would have liked to have seen having at least 100 million doses available. Now, that is Baylor Medical schools, Dr Peter Hotez. The number of Americans lost to covert in the past pandemic now it past year now about 510,000. But recent weeks have shown some or encouraging transgender Gavin Newsom says he sees light at the end of California's long covert tunnel. Now that the state has given out more than eight million vaccine doses, more than six nations in the world knew Semanales, California King Says have dropped from 17,000 to less than 6000 in a month and a half, and the positivity rate is now below 3%. He said he hopes to add the Johnson and Johnson single shot vaccine to the states supply. We anticipate receiving 380,300 doses of the J and J vaccine next week. Luciano CBS News Los Angeles Democratically controlled House is expected to vote tonight along mostly party lines to approve that huge panda neck stimulus package. The president has been pushing and pushing hard Speaker Nancy Pelosi salute a president Biden for his American rescue plan. Its outlook in the Senate. More cloudy. As for the president, he has gone toe weather battered Texas President Biden and the first lady arrived in Houston together. Welcomed by Texas Governor Greg Abbott, the first lady headed to a food bank, the president to an emergency operation center for a firsthand look at the recovery from the winter weather that walloped the state. My mother would say you're doing God's work at the Houston Food Bank, First lady Jill Biden.
The Latest: US loosens Pfizer vaccine shipping regulations
"Hi Mike Rossi you're reporting government regulators ease the temperature requirements for the Fizer coronavirus vaccine new data from the manufacturers has prompted the food and drug administration to loosen shipping and storage requirements for the Fizer Cole did nineteen vaccine the FDA says going forward the Fizer vaccine can be shipped and stored for up to two weeks at temperatures of freezers commonly found in pharmacies until now ultracold temperatures from minus seventy six degrees to minus one hundred twelve degrees Fahrenheit or required for shipments and storage of the frozen Fizer vaccine vials the chain should ease distribution and administration of the Fizer vaccine might cross CO Washington
Fresh update on "pfizer" discussed on NPR News Now
"So many more people who are very talented people. President biden is scheduled to visit a covid nineteen vaccination center. That's been set up a houston stadium later tonight. Wall street ended the day mixed territory. This is npr in the philippines. Kobe nineteen cases spike to numbers not seen in months the country getting six hundred thousand doses of the chinese vaccines sino vex. This weekend donated by china. Npr's julie mccarthy reports. this will be the country's first vaccine delivery president rodrigo duterte spokesman says mechanism to compensate filipinos. Who may suffer adverse effects or death from being vaccinated has been signed into law. The lack of such a measure to indemnify vaccine makers against damages has been holding up delivery aback scenes one hundred and seventeen thousand pfizer doses and over half a million shots from sino. Vacs do tae whose foreign policy embraces beijing will be on hand to receive the chinese vaccine researchers in brazil found it was slightly over fifty percent effective in healthcare workers which worries philippine doctors nurses and orderlies but the government says they are free to decline the sign of act. Shot julie mccarthy. Npr news in nigeria. Police a gunman abducted three hundred seventeen girls from a boarding school in the northern part of the country. It's the latest abduction of school children. In the west african country. Police say they and the military have started joint operations to rescue the girls. After the attack. In zamfara state several groups of armed men are known to kidnap for money and the release of their members from jail critical prices lower by the close down more than three percent and at sixty one dollars fifty cents a barrel on the new york mercantile exchange. I'm jeanine herbst and you're listening to npr news..
Will vaccines make a difference responding to the next outbreak?
"I'm health reported teigen tyler and physician in journalists alter norman swan. It's the last corona cast of summer fridays. twenty-six yes. We are on the last current cost of summer. And i feel like i am. Maybe potentially jinxing us by talking about an outbreak. But let's talk about the scenario norman. Where if there was another outbreak in australia. Now that we've got vaccine in the country vaccine which we know is quite effective at preventing disease and infection. Would that change the way. We've been responding to outbreaks in the past year. Yes would and in fact. I think we were probably the first out. Let's talk about. It was called ring vaccination. And it's now part as far as i understand it over the national immunization or vaccinations strategy. So what you do is as you do your contact tracing you would ring-fence vaccination around the person who's got the disease and the people that have come in contact with and maybe even the people that they've come in contact with so primary contacts and secondary contacts and you would do that with the pfizer vaccine because you've got a strong response early and is only three weeks between doses so within three weeks you're fully immunized rather than the astro which might take twelve weeks to get up to that sort of level of antibody response and so a and it's a race against time so that you because the incubation periods five to eight days but what some of the research is showing is that you get an early response to particularly the pfizer vaccine. Maybe even the astro too so you get a pretty good resistance there early on so that would be a good way to respond to outbreaks prior to very large percentage of the population being covered. So when you vaccinate sometimes depending on the disease some vaccines take a couple of weeks before you get an immune response. But then there's other vaccines like rabies. Where if you get bitten and you think that there's a chance got exposed to rabies. They give you a vaccine then. Do we know what the fires a shot does. Whether it's the sort of vaccine that you can give after exposure and give you some protection while it is all about the maths which is the incubation period versus the time for the vaccine to work so smallpox that's how they controlled. Smallpox control smallpox by massimo. Certainly helped but in places such as africa they controlled it by ringfencing and controlling the spread from that and so they find they find a case a main they ring vaccinated around the person with smallpox. So that in for anybody who might have contact come in contact with that person was protected and in that case the vaccine for for the smallpox vaccine worked faster than the incubation period of smallpox. In this case it's lying ball but it's worth doing because it's likely that you would get a responsibility and you're doing two things by this ring. Fencing are ring vaccination. I should call it. You are protecting somebody against severe covid. Nineteen disease the second thing you'd be doing is trying to prevent transmission and you'd hope those two things go hand in hand is a bit of evidence from israel that they do but it's not strong
Fresh "Pfizer" from The Editors
"Million doses come from the manufacturers to the states and the states are just not getting them out there into people's arms. Now you could say oh well jim. This is bad weather and yes to ago about ten days ago. We had really bad weather. The deep freeze also ted cruz and his vacation and all that stuff. And okay yeah. That's that's eight but we're we're now nine days past that there could be some You know factor and kind of domino effects down the line of the sort of thing but you pfizer. Moderna seemed to be able to get the doses to the states with with no real problems these days delivering like four million five million doses a day some days so the question is what is the problem in getting them into people's arms a couple of weeks ago. The biden administration said to a bunch of states. We're going to help you distribute them. We're gonna federally. Funded.
Pfizer Covid-19 vaccine works well in big 'real world' test
"Major peer reviewed study of the real world effectiveness of the Fizer covered 19 vaccine has just been published this morning, and it's very good news. The paper in the New England Journal of Medicine based on data from 600,000 people have received the Fizer by on tech vaccine in Israel that data showing the vaccine reduced, symptomatic covered 19 by 94% and severe illness by 92%. And people have gotten both doses of the vaccine. Those who just got in the first, Oh still showed a significant reduction in covert 19 cases. Study ASSESS data gathered in December and January time when the so called UK variant of the Corona virus was already circulating in Israel.
A third Pfizer dose? The Covid-19 vaccine maker is studying booster shots.
"Effectiveness it preventing Corona virus infection after two doses of its vaccine visor is now seeing what a third dose might do. The company announced today that a booster dose is being studied among people who received their first doses of the vaccine more than six months ago. You're not
Fauci urges Americans to take whatever vaccine is available
"A third vaccine is likely to soon join the covert nineteen fight but the nation's top infectious disease expert is urging Americans not to be picky Dr Anthony Fauci knows people look at vaccine studies and compare effectiveness seventy two percent versus ninety five percent and so on they may then decide well just wait for the next more effective one that I think is not a good idea algae on NBC news today show saying people should be confident in any vaccine the FDA approves for emergency use when the vaccine becomes available take it Johnson and Johnson's vaccine will take its turn before the FDA's independent advisers tomorrow and felt she's looking forward to with joining the dharna and Pfizer vaccines already in use they have to it's fine to have three is absolutely better soccer mag ani Washington
Pfizer's vaccine trial data holds up in the real world
"More again on the pandemic and the promising news about vaccines that Seems to continue to pile up of late. We're joined now by Dr Amos, a doll jah, senior scholar at the Johns Hopkins Center for Health Security and a professor of the Johns Hopkins Bloomberg School of Public Health. It's always good to get your insights doctor and I want to get your take on this latest study out of Israel that seems to verify the clinical data we got on the Fizer vaccine that it seems to be Just about a super effective in the real world as it is in lab settings. What do you make of this pure reviewed study? This is great news because we always know that it's one thing when you're in a clinical trial, and you've got a lot of protocols and certain people who volunteer for those clinical trials, and then you move from that setting to the real world where things can be a little bit more messy. Are there a lot of variables that might not have been accounted for in the clinical trial, and that's what we really understand how effective the vaccine is moving from F ethical efficacy Studies to Real world Effective ists. I think this is good news, and it really cemented the fact that these vaccines are the passport and the way we get our lives back and put this pandemic to rest doesn't make you think that vaccines could get us to herd immunity that it'll be vaccines alone. That could get us to that step that we all want to see. Do you think that vaccines will eventually get us to herd immunity? But it won't be vaccines alone because already one third of the population in the U. S likely has some level of immunity from prior infection. Herd immunity, although it's a major milestone to reach. It's not the only thing I think to me the biggest The biggest milestone would be vaccinating are vulnerable populations completely so that this virus can never cause serious illness, hospitalization or death again that it could never threaten hospital capacity. I think we were will get there first. And then eventually herd immunity will will come. So I think the key is really taming this virus, making an unable to cause serious disease. And that's why our vaccine allocation process is geared towards those who are most likely to have severe disease. And I think we'll get there first. Before we hit hurted me. Did he speak about vulnerable populations? Doctor? I wonder if you're also thinking about the racial disparity that we continue to see in the vaccine distribution effort we saw Further evidence of that on the Bloomberg vaccine tracker just yesterday. What's it going to take to sort of bridge the gap between black populations receiving the vaccine and white populations? It's going to be very, very challenging. And I think that The more people that get back stated. The more people in those communities that are vaccine hesitant or afraid to get back there because they're on trusting of the of the vaccine or public health authorities. The more they see people get vaccinated and nothing untoward happened. I think the better it is. But I do think we need specific outreach to those programs to those individuals specific programs that really trying address their concerns almost on individual basis, because if that group does not get back stated they still represent they represent some of the people that are most risk for. Of your disease. They're disproportionately the ones who've died from this. We have to do better in order to put this pandemic to an end. And I think it's going to be challenging. And I think we're gonna need the innovative solutions. We're going to the community leaders to really Show people the data and be very transparent about how effective these vaccines have been in go through all of the safety data and hopefully persuade them to get vaccinated at much higher rates than they have been. Our last minute here. What's your level of concern about some of the latest variants we're seeing reports on with there's a New York Times report just this morning about a variant in New York City that seems to be spreading pretty rapidly and could blunt the effectiveness of vaccines. Yeah, it's hard to know exactly how to take all the news of the variance. We know that this virus has been making variants as soon as it jumped into humans and most very instead from made headlines have never made The New York Times Because they didn't change the way the virus behave. But there are some that appeared to have made the virus more contagious. Some that have Changed the way the virus interacts with the immune system and those air more concerning, But I do think when you look at our vaccine data against these areas, including ones that are more Troublesome like the one that they call the South African variant of the resilient variant. The vaccine's still do remarkably well on what matters. Preventing severe illness, hospitalization and death. So I do think that the goal when it comes to these variants is to stay ahead of them by accelerating vaccination programs to the fastest possibles rate. Some of these various don't pose a problem, but I think we need to do better attracting them and understanding them. But not everyone that you see is going to rise to prominence and I think we're getting better now at tracking them. Sequencing, and so you're going to hear more about various, but not all of them are going to be of the same important that it's gonna take some time. Specifically all of that.
Johnson & Johnson COVID-19 vaccine deemed "safe and effective" by the FDA
"And johnson. It's been shown that they're vaccine is effective at preventing hospitalizations and severe effects of covid. Nineteen this from scientists at the fda we're seeing about. I think it's sixty six percent effective when it comes to moderate to severe cases of covid nineteen so matthew. Tell a little bit more about what we're hearing with. His johnson and johnson vaccine right so what happened. Is that johnson. Johnson released data about a month ago. You know press release but the process for evaluating these vaccines is that they go through the fda and the fda really unique in the world independently looks at the data and re analyzes the data that the company produces and its own report and then hold a public meeting which will be happening friday and so the documents before the public meeting came out and they had some good news both some really clear data on hospitalizations and a general sense of approval from the fda researchers. Sometimes they're not as positive so it looks like this may be another option now. The big plus is on. This is one. It's a one shot dose. So you don't have to go back for a second jab in the arm and also doesn't need to be kept frozen like the pfizer derna vaccines do so shipping and handling of all of this will be a lot easier much easier to transport and that's a big advantage. It does not look like we're gonna have a huge amount of supply the start off with so it doesn't dramatically change how fast we're going to be any shots into people's arms but for a lot of people i think in a lot of experts i talked. You think this'll be a great option. It's one and done. I think some of the numbers. I saw the might have about four. That are produced right now. Ready to send out so it gets approved. They can get those out really quick but it wouldn't be until april possibly where they can really ramp up production to start distributing that right and will also be getting over that where they're hundreds of millions of doses of the two vaccines have the madonna and fayza biontech vaccines. That are expected to arrive in the us by july. So there's gonna be a lot more vaccine available. The jj supply will ramp up and we'll be getting more of those other two vaccines that leaves. There's a vaccine coming from nova vacs. We don't really know about how much will getting the early results issued press. Release again good and we're waiting for. Us results on the astra zeneca vaccine. Now some good news. With his johnson and johnson one is its effectiveness against these variants. That we've been hearing a lot about so it fared better than expected when it comes to those. I the way to interpret. That is we'd seen some results and the new results that they showed today look a bit better than what we'd seen in terms of variants. There's still does seem to be decreased. Efficacy against the south africa variant. Three five. Which is really the one that we're all worried about but it did look better than what we've seen previously and what j. j. has said it seems like with those variants. This vaccine is still preventing severe disease and hospitalization. Which are the key things. We've always wanted from vaccine here. The idea that you'd prevent a symptomatic infection or mild cases kind of bonus compared to just making sure that people end up in the hospital hospitalizations numbers were good on that front. What did we see when it comes to side effects. I saw that there were a few unexpected side effects. Although these are very rare you know but The expecting side effects the kind of pain in the arm the headache fatigue. That's pretty much in line with the other two vaccines. We have that right now. There were some rare events that occurred more often in the vaccine in the placebo group. Keeping in mind that forty thousand people were in this trial. There were fifteen serious blood clots including some. Dvd's in that exciting compared to ten in the placebo group. That's something the fda plans to monitor there was also some rini ears in the vaccine group and not in the placebo group. So that's kind of an odd one that will wanna watch again. This is really a prelude to friday win. Some of the top experts in the world are going to gather on zoom call and go over these data that the fda assembled we'll be live blogging that stat. That's when we really find out a lot about any medical product. It's it's one of the amazing things. The fda does now an interesting thing in all of this so public health officials might have a messaging problem when it comes to pumping the johnson and johnson. One out when we're seeing guys like pfizer maderna's say that their vaccine is ninety five percent effective against corona virus. Just listening to numbers right. This says sixty six percent. So what are they going to have a challenge in getting people to want to take this one over the other or you know how how to work out. It's really important to realize that particularly between those three vaccines. The getting vaccine is much better than not getting a vaccine. The change vaccine may be on par after a second dose and that study is being done but unlike visor during the second dose is going to be months after the first and then also slows down the study. She gotta wait right for people to get their second dose. So we're not expecting those data until kinda summerish but the big thing is for a lot of people. There was also the appeal of a single dose here. And i don't think we should understate that. And the effect on severe disease is big so the problem is gonna be the in the initial rollout. You really want people to take whatever vaccine. They're giving because being vaccinated is so much better than not being vaccinated. And that is part of the path to get in the world back to normal and public health. Authorities are absolutely going to have to articulate that now again because there's not going to be that much supply of this initially. They're going to have time for a learning curve right now. the demand for vaccines clearly outstrips supply. That's why you're hearing so many stories of people desperately logging on trying to get vaccine. What scott gottlieb used to run. The fda has raised the issue of you know. We're we're going to reach a point where the people who wanna get vaccinated we'll have been vaccinated and we're still going to need to vaccinate more people and that's when convincing people who are less sure to take vaccine in to take the vaccine that's available is going to become more of an issue last question briefly pfizer moderna vaccines are based on 'em a. What kind of platform is the johnson and johnson. When using this like theatrics annika vaccine is called an ad no virus which is a kind of virus that is used to the same kind of ideas marin a the instead of traditional vaccines were you inject the protein that your immune system sees and then learn to recognize an attack. These sneak something into your body that makes a lot of proteins. You make a lot more protein and then the body recognizes that an attack it in this case they're using this virus which is kind of a cold virus to sneak some genetic material in and that makes the spike protein from the sars virus which your body then learns to recognize and thereby has antibodies that attack the virus
Pfizer COVID vaccine found 94% effective in real-world study
"A real world testifies vaccine and more than half a million people in israel confirms that even after one dose it's very effective at preventing serious illness or death ninety two percent effective at preventing severe disease after two shots and sixty two percent after one and it was equally effective in young people. And those over seventy. The fda is one step closer to authorizing johnson and johnson's one dose vaccine for emergency use panel meets tomorrow to make a recommendation so far. The fda's review noted the vaccine to be sixty six percent effective overall in preventing moderate to severe covid nineteen and it has a favorable safety profile.
A Small Molecule Cancer Drug That Promotes an Adaptive Immune Response
"Matt. Thanks for joining us. It's a pleasure nice to meet you. Danny i'm glad to be here. We're going to talk about fos flatten. Its lead therapy. Which has multiple mechanisms of action and how it works to enlist the immune system to kill cancer cells. Let's start with your lead therapeutic. Pt on twelve. Which is a first class. Harrow phosphate platinum conjugate. Break that down in simple terms. What is it thank you. That's a good question. I think maybe i'll just briefly tell you a little bit about the company and how we got to where we are with this molecule. Pt one to foss platin- therapeutics was founded by myself. And our ceo robert fallon my fellow co founder in two thousand ten and we really built the the company around this family of compounds that we in license at the discovery. Stage which comprise these Family of these first in class pi-rre phosphate platinum conjugates and based in new york. Although these days that that means something different than it used to We have a nice Small office here in midtown with our management team. Of course now are all working remotely and we worked our way through preclinical and early clinical development by running collaborations around the world. We've actually had worked ongoing in fifteen countries Since we started and These are academe amick. A- collaborations contract research organizations clinical sites but also industry collaborators We we have a an existing collaboration with pfizer and their co-development partner. Md serono or merck darmstadt on one of the combination programs that were running and we're still private company in early phase two development with pt. One too so to your question about pt to is a small molecule and actually to our knowledge. It's the first anti cancer agent containing a pirate phosphate and This has implications on its safety. Its pharmacokinetics to mechanism of action. And even on its. It's targeting where it's delivery within the body and i'm sure we can get into that further as we go. I generally think of conjugated therapies is linking targeting mechanism to a- warhead. I take it the way. Pt one to works is a bit different. What exactly conjugated in pt. One two and what to each those components do it's a great question i think we. We certainly are not an antibody drug conjugate. I don't want to give that impression. I think we're thinking of conjugation. As a medicinal chemistry term that goes back to certainly before the advent of of adc's in cancer care Our inventor of the late refunder bose was actually the first researcher able to successfully link or conjugate a pyro phosphate to platinum core molecule. And of course Platinum molecules with platinum in their core have been a mainstay of of cancer. Care for some time now. He was really seeking through his work in medicinal chemistry To find a new paradigm for a platinum containing agents he did so by congregating power phosphate. And what that does is because the para phosphate is so strongly linked. It remains intact for the most part in the body theory differently from cytotoxic agents and certainly from other platinum containing agents Pyro phosphate also benign in the body Native to healthy cells so you'll the respiration so we're not adding something that's in and of itself toxic
FDA says single-dose shot from J&J prevents severe COVID
"The food and drug administration analysis finds Johnson and Johnson's single dose vaccine offers strong protection against severe covert nineteen the report confirms that overall the vaccine is about sixty six percent effective at preventing moderate to severe illness from covert nineteen FDA advisory board member Dr Paul Offit you wanted to keep you out of the hospital added the intensive care unit and execute and and certainly all the vaccines buys Russian drug acts in the past and Johnson thank you to do exactly that that's what you want I often ask people shouldn't be dissuaded if the Madura and Pfizer shocks appear more effective in trials it's always subtle differences in the way that those trials are done it may make the difference is that I think you see here but that aren't necessarily relevant when she got in the real world the FDA is expected to make a final decision on emergency use of the Johnson and Johnson vaccine within days Ben Thomas Washington
What happens if you get the wrong dose?
"And so norman vaccine relative happening the government indicated earlier this week. That in the role that they were going to be mistakes made and we saw one of your day. We saw an idea year old man and a ninety four year old woman in brisbane though given the incorrect dose of the five vaccine and they're not sure it's all under investigation at the moment. They may have been given up to four times the amount of vaccine. So can you guys on a vaccine is it. Is it a safety problem. And what have health authorities done right and wrong in this situation. Well the first thing i want to do is give a huge shy type on this to both the commonwealth and queensland health because this is the textbook way so if you are feeling a corpus are unsettled about this in terms of the rollout of the vaccine i on the other hand find this reassuring hugely reassuring because what happened here was. Let's just go through it. There was a mistake. Made the nurse notice it and called it out and the authorities have not hidden it. They've been transparent about it and there's going to be an investigation and we'll learn from it. That's exactly the way safety and quality should work in healthcare. Mistakes will occur all the time. This just not happen more than once. It's unfortunate for the people who experienced them but human error is inevitable but the way to deal with it. Is that anybody who sees a mistake. Be able to call it out so for example if you're a daughter scrub nursing theater and you see a senior surgeon to making a mistake you call them out on and you are transparent about it. You don't hide it and so nothing has been hidden here since gives me huge confidence that the system is going to be safe and protect against human error. So i'm i'm reassured. By second thing is what about the man and the woman who were immunized. Is this a risk for them. The have been trials of the pfizer vaccine where they have tried out higher doses and my understanding is that those higher doses where safe did not produce side effects. And i think what's happened probably over. The course of the trial is to preserve the vaccine. They've tried to fight the lowest does. That's most effective and that'll be the does that's being administered. Not in theory. You could possibly get out of over reaction in the immune system. That's possible particularly with these mini vaccines but the fact that these people are elderly. They've got reduced immunity in the first place. And it's unlikely you're going to get that problem so you can have problems with too much vaccine. But hopefully they will be fine
Pfizer and Moderna ramping up coronavirus vaccine supplies
"Is being delivered. Fizer and Moderna expected by the end of March, they'll of triple the number of doses delivered so far, and Johnson and Johnson could get emergency use approval of its vaccine candidate by week. Send prepared to ship immediately upon emergency use authorization. Nearly four million doses of our vaccine Doctor Richard Nettles is a J and J vice president. It's a one dose vaccine that doesn't need ultra cold temperatures for shipping and storage. Our vaccine can be distributed using the existing supply chain and routine refrigeration. We used to transport other medicines. Today. Officials formerly in charge of U. S
Pfizer and Moderna ramping up coronavirus vaccine supplies
"Million americans have received. At least one vaccine does while hospitalizations continued to decline now at about fifty five thousand and today top back in makers were grilled about. Whether they'll be able to deliver the doses. They've promised. Tom castillo has more with the fda expected to grant emergency authorization for johnson and johnson single-dose vaccine within days. The hope is that vaccine supply will meet demand within months so far nearly twenty million americans are fully vaccinated today. Congress asked all five vaccine makers for a status report in current production levels. Are you going to be able to meet that deadline visor. We anticipate that we will be on track to deliver those three hundred million doses before the end of july moderna. Three hundred million by the end of july. We do believe ron type to meet those deadlines j. and j. As soon as next week we are on track to deliver that. What does this by. The end of astra zeneca not yet approved. We'll deliver the three and a million auto novak's not yet approved. We would be prepared by the end of june To produce that hundred million doses all of those doses could lead to a vaccine glut in the us. Meanwhile la's mass vaccination sites are back up and running after being resupplied and several states are now prioritizing teachers including california oklahoma tennessee and connecticut. In new york eighty-one people who received shots have learned. they'll need a third shot because they're vaccine doses had not been kept cold enough though pose. No risk vaccine makers say. It's still not clear. How long vaccine protection less. Unfortunately the only way we will know about the duration of protection is overtime vaccine makers say that's why they're looking at new booster shots that may be required for years to guard against new virus. Variants
Pfizer and Moderna ramping up coronavirus vaccine supplies
"Drug makers of the coven 19 vaccines were on Capitol Hill, answering questions about the limited supply visor and Moderna say that they'll have 220 million vaccine doses. And they'll have them ready by the end of March. Johnson and Johnson's vice president of medical affairs, Dr Richard Nettles, says they're one dose vaccine is expected to get a green light from regulators very soon. We will have 20 million doses of the vaccine to be made available by the end of March, and we're prepared to ship immediately upon emergency use authorization. Nearly four million doses of our vaccine. The pace of vaccinations has been picking up nationwide, but health experts are really worried about a number of variants of the Corona virus.
UNICEF begins shipping syringes for the global rollout of COVID-19 vaccines
"Critical task of ensuring that all countries have enough medical equipment to vaccinate people safely against covid nineteen gathered pace on tuesday with news. That one hundred thousand syringes have been sent to the maldives ahead of an inoculation drive. The shipment is part of the first wave of syringes and safety boxes organized. By the un children's fund unicef over the next few weeks the agency plans to dispatch more than fourteen and a half million single use needles to more than thirty countries including cote d'ivoire sotomayor and principi. These include the point. Five milliliter syringes. Which meant for use with the astrazeneca vaccine while the point. Three millimeter version is for the pfizer bio entex shot in total unicef aims to supply up to one billion syringes and ten million safety boxes to countries in two thousand and twenty one ahead of the broader rollout of new corona virus vaccines in eighty two low end low to middle income countries
Pfizer COVID-19 vaccine greatly reduces virus transmission, Israeli studies show
"To Israeli studies have found that Fizer Cove in 19 vaccine greatly reduces virus transmission. Shedding light on one of the biggest questions of the global effort to quash the pandemic. Data analysis and a study by the Israeli Health Ministry and Visor found the Fizer vaccine developed with Germany's beyond Tech. Reduces infection, including an asymptomatic cases by 89% and in symptomatic cases by 94%. The findings air from a pre published study not yet peer reviewed but based on a national database that is one of the world's most advanced a separate study. By Israel's Sheba Medical Center, published Friday in The Lancet medical journal found that among 7200 hospital staff who received their first dose in January There was an 85% reduction in symptomatic covert 19 within 15 to 28 days with an overall reduction of infections, including asymptomatic cases detected by testing of 75%. More research is needed to draw a definitive conclusion. But the studies are among the first to suggest a vaccine may stop the spread of the novel coronavirus and not just prevent the people vaccinated from getting ill. Dr Jon Swartz and Burn cold clinical professor emeritus of infectious diseases at the UC Berkeley School of Public Health. The implications of this are enormous Republicans standpoints in vermin individual standpoint. If if the If these numbers are even numbers significantly less than this hold true, that is that once fully vaccinated. Well, first of all we know once fully vaccinated. It's Very, very, very, very unlikely. We're going to get seriously all and there's no evidence that you'll die after you being fully vaccinated. So we know that. But what if after you're fully vaccine, you get reinfected. We know you're not gonna get sick, but you could spread it. But what if you can't spread it? Or what? If it's very unlikely for you to spread it? It's gonna really mean that our masks they're going to come off sooner that we're gonna be hugging her loved ones a lot sooner right now. I'm fully vaccinated have been fully vaccinated now for this Just actually, three weeks today, um If I knew that I couldn't transmit this virus to my loved ones, I would My strategy would be very different. If I may ask you really come off. I could be hugging. Uh huh. But I don't know that yet, And so I have to still remain vigilant. And that is where a mask and social distance to be absolutely certain that I can't do that and think about all the health care workers. If the health care workers knew that they didn't it once they're fully vaccinated, they wouldn't transmit that would make an enormous difference in the hospitals. And think about just Transportation. It's just goes all the way down the line. So the implications are
"pfizer" Discussed on Pwned: The Information Security Podcast
"What's up everybody this zach. I'm here justin justin. What's up so we are here with another breach of the week. And this is a doozy. This is So we're looking into iser and a data breach that they had due to unsecured cloud storage which hits on a whole bunch of the things we've talked about in the past one being and that really important data that you do not wanna get released because that creates all sorts of not just like the general like. Oh this sucks that there is a release but you've got like regulatory issues. The deal with generally frowned upon. If you yes. I mean the health information general is just not you know. You don't want anyone known about those like weird things you have wrong with you and so you've got some hip but more. Interestingly was also a failure like it looks like they were trying to do a good job so they have cloud data. Which we've said is a good way to sort of segment data off your system and protect it. Everybody's always get good intentions. But the breach was caused by unsecured cloud storage and they. It's it was found basically to be a miskin figured cloud storage system or they just set up their google cloud. Which i guess. I don't know when i think of google cloud i. It seems like that's something that i wouldn't expect a company like pfizer to do like i would sort of think that they've got their own system. And that's visors a multinational and obviously they're right now. They're probably making ungodly amounts many. Because i think they're one of the candidates that's trying to make the this is very reminiscent to a bank capital one. Yes so same. Same thing out while they were they were amazon. Yes cloud so i guess similar i hate capital i should probably say. Hey capital one wrong word. I really visually. I've had a few credit cards in my time. Capital was one of the worst ones. That i've that i had i. I couldn't get out of the card. I tried to pay it off in that. I wanted to shut it down. They like wh- like i had to go through so many layers to actually shut the car down. It's like they got me. He was one of those things where i was at college. Groundhog day. Pretty much like is it done like. Oh no you need to talk to this person but it was in college in. You know how that goes you like offered. Here's a credit card to go. Whatever you want about a really crappy laptop with it which was even more disappointing laptop stunk. It no god. Now that thing. I think i sold that to some poor doodoo about computers than i did or yeah yeah i feel bad but i was young johnny better so in this case though like so it sounds like maybe this has a little bit to do with what we and i don't know when this is gonna come out so we've either talked about it or we'll talk about it like privilege access. Which one of our partners. Cyber ark deals worth But the sounds like it might have been. It was a misconception geared cloud that that opened up access so i'm guessing it means they probably there was there was roles that maybe were created that provided someone an avenue in that should never or a path was created on accident. Or it's not a not a ton of information about the care that i can see but it looks like ms configuration at the storage level. It sounds like they caught it. Maybe during an audit or something that it was like they didn't know about it like wasn't captured as it was happening or there wasn't like maybe the indicators has sort of traveling through the system it sounds like maybe they were like. Oh yeah that looks like someone maybe got into this. That shouldn't have and downloaded the data. that shouldn't have. Yeah which is which is usually happen. Which could even be. I mean i guess. Here's a question so this isn't this isn't the first breach for pfizer. They've had a long history of Let stuff go okay. So that's true. I mean you know there's companies feel very evil. Even though they do really good things. I think it's just because there's so much money involved. That just feels like one of those very evil things so just out of curiosity if this was so. Let's say this was caught during an audit for instance. So this it doesn't necessarily mean that there was ill intent right so it could have been like an admin who maybe was or someone you know got fired in on their way out. They're like oh. I need to back these up before i leave. And they're like oh. That was not supposed to have been done that way. That could technically be considered a breach because it sort of approach. I'm guessing in this case. They wouldn't have announced that if the data had gone into somewhere where it could be exposed by right but it doesn't always mean that you know necessarily that. There's ill-intent right. It could have been done through. An accident and exposure occurred
"pfizer" Discussed on Coronacast
"So i know in that. Within the last few weeks and month there's been millions and millions of devices of coronavirus vaccines going into people's arms. All around the world and one of the front runners as we talked about in detail yesterday. Is the fires a shot. So when we've been looking at things in a clinical trial setting get an idea of safety and efficacy and all of those other scienc- words now that we've seen this thing rolling out in millions and millions of people globally. What extra detail do we now have about. Especially the sizes shot just to really tease that out. A little bit from what you said is the trials have been done on an average of maybe forty thousand people which means twenty thousand people get the vaccine twenty thousand people gates the placebo. All that tells you is does it work and is it safe. In twenty thousand people compared to placebo. So what happened. In in the phase three trials of pfizer moderna and astra is that they showed effectiveness to a varying extent and they showed that there were no serious side effects and therefore good to go to approve and release over. There are more daughter to balut tat. Which is what's happening here in australia. So that's to but rare side effects are only going to emerge after the trial just rare side effects but side effects where in the real world. You're not as selective as you are on the trial so a good example of that with pfizer. Thanks seniors the in their trial. They did not recruit people who had a history of nfl shock of severe. And what happens when it was released. One of the components almost certainly was causing antic shock and people who are susceptible and therefore. Now there'd be very careful about fis are and allergy and people with nf alexis. Let's assume for example that the norwegian norwegian cases of these frail terminally ill. Let's assume that that is linked to the vaccine. Oh vet still a question as we record this corona cast then what might happen as a result of that is even. If it's just precautionary you might say. Look people who are over. Eighty five frail and if you think that they might die in the next few months. Don't give them this vaccine just to be so you kind of refined the indications in other words the group of people for whom this gets the you get the vaccine and it's really only possible when you re rolling out to millions and millions of people and might be a one in a million side effect which is really really serious which you can't avoid by refining. Who gets it award in which case the vaccine might have to be ceased and move on to another vaccine and those are the things that you learn as you move on now. The good news as we said last week on krona cast. Was that when you look at. Israel still not being published but if you look at israel where they got really great electronic records that are integrated and they compare the people that they've immunized with the people yet to be immunized it looks as though there's reduced transmission which is really the the pot of gold at the end of the rainbow for these vaccines. So you're in good things and you things that are maybe problems and <hes>. It's unprecedented that within a year of this infection hitting we've not only develop vaccines and trialed them that they're now have been given to maybe twenty million people a lot of which has recorded in good electronic databases so that you can get onto this post marketing surveillance. I mean some drugs for example. Take years to find these side effects. And sometimes they're missed for years because doctors are really lousy at reporting side effects. And then you find the find the might this way. They're going to be find out much sooner more effectively and be able to find out whether it is coincidence or really attached to the vaccine
"pfizer" Discussed on Lovett or Leave It
"Don't go anywhere. there's more of love it or leave it coming up. Love it or leave. It is brought to you by lord jones. We have a new sponsor to a really excited about lourdes. Jones makers of the world's finest dvd product cbd is all the rage these days but pioneering brand lord jones is considered the gold standard for years. They've been changing people's lives with their premium cd products. Laura jones has been favored among celebrities worldwide. Showing up in the instagram feeds of hollywood's. Biggest names wow stars. They're just like us on cd. Another inviting you to experience. The finest cbd products available like some of the biggest names in the world from world-class skincare to tinctures to decadent. Gumdrops confections a phrase. That's come so natural to me if you're curious about what. Cbd can do for you trust us you want to start with the vast and they are the best jones great It's very nice stuff. I'm a huge fan. Here's the thing. I've said this before. And i'll say it again. They're cbd there's thc sometimes it's hard to not have either right versus nothing. You might want that. Thc but cbd instead of t. h. e. That's a great call. I really recommend that you know you follow your own advice. Sure i do.
"pfizer" Discussed on Lovett or Leave It
"How are you thinking about this challenge right now about how we make an argument for democracy itself how campaign for these sort of bedrock american principles that seem to have lost purchase in one of our two parties. I don't have an easy answer for that. But i will say that you know looking back not just on the election results but thinking about this in the in the sort of sweep of history you know maybe we should have pointed out the corruption a little more aggressively and not assume that. Just because some pollster told us that. Aca was the main thing that it was always the main thing now. There is a theory of the case. That when you're dealing with elected leaders with fascist tendencies that if you freak out too aggressively about the behavior right about the anti-democratic behaviour that you can't win this arguably happened with berlusconi and there are other examples of if you don't focus on bread and butter issues you sort of never get over the threshold of actually winning a working majority. But i think it's just worth pointing out that you've got Seventeen attorneys general Hundred i think a hundred members of the us house who wants to overturn democratic election. There are plenty of elected republicans. Maybe not quite half of them. But a really strong and alarming plurality of elected republicans who are proudly saying that they want to overturn the election on the basis of nothing other than their guy didn't win. And and if we don't make the case that that's disqualifying for them as a party. Then shame on us now. Does that mean it's the main thing we're talking about. Every every time we open our mouth. Maybe not but i feel a little sheepish about the extent to which i prioritize message discipline. Right right Over my own instincts to say these people are actually overturning. Everything that we hold dear. You are among many. That have been sort of sounding this alarm. It's it's actually. I think it's harder problem. Which is we can't solve it in one election right like okay. We talked about it more. The problems deeper than that right because it takes a very long time for these kinds of ideas. It seems that this rejection of democracy has been taking hold for a very long time. It seems like we have to just be honest. That talking about it won't be the answer for a long time. We have to make a really concerted long-term case to figure out how to convince millions of seventy five million some odd people they voted for donald trump who maybe are receptive to an argument. That democracy is a good thing. Yeah we should try to uphold that well you know. One of my colleagues in the senate was talking about part of the reason for the distrusted institution. You know there's the party problem. There's the fox news ecosystem and facebook and talk radio but it is also that institutions have stopped working for people and so it's not just a theoretical thing or filter bubble or question of what our messaging is it's that the institutions that people used to rely upon whether it was their union or their church or their government to make their lives better are not making their lives better to the extent that it used you.
"pfizer" Discussed on Lovett or Leave It
"Genius. It's simple that gets here. That's the bug the earworm. That's gonna win so good so good. John the guy that they made his nose bigger in an ad so he'd look a little more a wink. Wink you now. What a little more little more new york. Yeah little uh must see tv. Yeah that was when it was Seinfeld and riser and jonathan silverman and one strain. She's a little must see tv. The three parentheses of times man. That was what a block that was Triumph for the jews. And now melges. I will say this. I remember like kasai was on and i remember we go onto the festivus episode and it was like. Am i on mars. Are we sitting here pretending that george costanza is christian like am i an outer space. He's italian right. Jerry stiller his dad. We're talking these are non jews. These are people that have christmas presents. Play italians. I know but it was a shock to me. I didn't play at tough italians right. No i feel like deniro. there have been some. There's been some we've gone in both directions we've gone. both directions. scenario gets to play anything. The rain bronco played jewish in goodfellas. I believe yeah. I believe her character was jewish. Yes carol parents were none too pleased with that situation and i felt very true to me in georgia. It was announced. That joe biden might send pete buttigieg to china as ambassador after comma. Harris made the suggestion to joe biden. Zoom with her camera off sounding suspiciously like amy klobuchar. Exacting revenge yeah. I don't mayor to china. I think it's cool. I think it's cool if takes on that job. That's the job. George h w bush at. It's a really big ambassadorship. Just like the idea of amy klobuchar having carried a grudge and somehow managed to take over a comma harris zoom with with joe biden to kind of pull the strings. And it's like i am. You know. I imagine amy klobuchar descending from the ceiling in my mind amy. Klobuchar has become a kind of john wick figure who Scorched earth occasionally. Must you call upon her powers. It's funny everyone understands why like john. Wickets is dodd killed. He's going to murder a lot of people and it will be justified but human beings gang kills just like. Hey in the film face off. There is a moment in which nicholas cage in the body of john travolta or john travolta and the body of nicholas cage. I don't remember but one of them ends up in a prison. Just the prison you know and has to escape and he shoots his way out of the prisoner he. The prison just thinks it's a mastermind sue criminal. We know as as members of the audience that that's actually the the good guy in the body right so the good guy and the body. The bad guy has to escape from jail to the city but he shoots his way out of the prison. And i remember just sitting there in the theater being like from the point of view of the people working at the prison. This guy sucks just murdered. I always wanted to see a movie where it's like the good guy round killing a bunch of people and then it just goes to one of the people kills and you just back up and watch their whole life up until that point or those one of those fruit stands that james bond drives through. Yeah the faa..
"pfizer" Discussed on Lovett or Leave It
"The order certainly could have been as it allowed to host of confusing and seemingly contradictory exceptions. But i will say. Sarah i barely been able to keep up. I was really. I was at this amazing seven course dinner at the french laundry. They do this truffle. Foam it's exquisite gavin. Newsom gag right. Well you know what they've been so many people issuing orders and then going on various trips and restaurant meals. I mean it's not. The mayor of san francisco. Did something similar with the mayor of austin. Did something similar politicians across the country have been issuing these orders violating them and then and then like i don't know about without naming i won't name names but i don't know about us there but i have heard about one too many fancy. La rich people having secret events. There are so many people playing fast and loose. I can't even believe it. I don't trust anybody. I see my my dad's eighty three so and i see him at least once a week usually more. I can't take that shit home to him. No absolutely not. He's elderly he's elderly. I just turned fifty. I kept it real low key at a party of not even fifty people in a really small space first of all. I don't think cove it's going to believe you're fifty come on koa. No way are so. Yeah go ahead. You're too pretty to get cova. And so people are saying that people are saying a lot of people are saying that bernie sanders and republican josh. Hawley of come out for another round of stimulus checks in the white house has agreed to support six hundred dollar checks which would go a long way to paying off. Everyone's rent from the first two weeks of april very good. That's marvez snarky thing stark little snark little listener in georgia runoff news. Senator david purdue didn't show up for his televised debate against opponent john up and instead was represented by an empty lectern. Sadly debate ended in a tie off. I'm just voter us is off all right. Vote your ause off. Just kidding simple jingle. It's your johnny jasa. Ross the warna for georgia and the us a simple. Thanks a.
"pfizer" Discussed on Lovett or Leave It
"It used the code love at ten as they say in scotland. Sloan jay which has golic for. I'm excited to see tended in my house..
"pfizer" Discussed on Start Here
"It's friday december eleventh and one step away. From a vaccine we start. You have a favorable vote. The button food warp speed is sitting there. All the fda has to do now is pushing like tens of millions of americans who carry app pens and are going to want to know the answer to this question of scientist voted on the pfizer vaccine. And what they still have before there was a vaccine. How much did the white house one you listening to scientists. Anyway you have your political appointee really doing a lot of the white house. The president's bidding a missing email could some answers. Protesters got aggressive over police brutality. What happens when police of victims family during pandemic in cop rocks. And you have these makeshift spike strips. Put a board on it. The new breed of protests in oregon from abc news. This start here brad. Mielke there is going to be a moment. Could be today could be tomorrow's maybe sometime next week but there is going to be a moment. Soon when the food and drug administration will likely say okay. The pfizer vaccine that has been approved in the uk. It's been approved in canada. It's got the green light here. as well. at basically that moment pfizer is going to try to open their garage doors and senate millions of doses of vaccine out the door. Like unless you lived through world war. Two you will have never seen a government mobilization like this on our shores. I would not trust donald trump however throughout the year. People have been nervous about who to trust right. President trump downplayed the seriousness of the virus. Trump's opponents said hey if he's not going to be straight with us. Why should i trust is fda and would have to be a credible source of information that talks about the The efficacy and the and reliability of whatever he's talking about i will not take his word for we have one pet oedipus and that is discuss and vote on the emergency use authorization of the pfizer biontech cova nineteen vaccine. That is why yesterday was so big. The fda had this hearing there was a vote but the people voting were not from the fda. Most don't even work for the government. These were independent. Scientists who the fda invited to grill pfizer as hard as they could to determine whether this vaccine is actually safe last night. That group voted yes. Abc's and flaherty covers federal agencies and can can we skip to the end of the hearing. I like what what did that. Actual voting last night. So this was a big moment. Brad it was seventeen to four this panel of experts of very smart infectious disease. Experts and Doctors pediatricians okay. I think we are going to vote so great but let's pull up the on voting question on the and they were all asked one question which is looking at the data of this vaccine. Do the benefits outweigh the risks. And that concludes the vote. The we do have a favorable vote and that concludes this portion of the meeting. So and the majority voted. Yes so that's the bottom line like they. They spent all day essentially getting to that big headline question. What do they have to get. Now take me back. What are they have to get to first because there were lots of you know concerns big and small to deal with here so there is this concern about allergic reactions. We saw this in the uk with two people who had serious allergic reactions required. You know an epi pen injection so there were a lot of questions about that. They spend a lot of time on this broad who empty drag chief cheesecake lemon in life. And what we know. Is that pfizer had excluded people from their trials who were specifically allergic to the ingredients in their vaccine or who people who had had serious allergic reactions to vaccines in the past. So what they're trying to figure out. What is that mean. If i know somebody who has really bad allergies that they're not going to be allowed to take this vaccine at all or what. That was exactly that question that was asked mary can can. I just thought the one thing that will stop the if you look at the components of that vaccine which has the probably the longest chemical name of any vaccine. I've ever seen in terms of that the morning. Nobody's gonna look at that name and take you know i'm allergic to that. So here's what i would suggest. And dr often is a member of this panel. Said you know this. Tens of millions of americans who carry app pens and are going to want to know the answer to this question so it looks like the answer that they came to. Is you have to go back and study it. You have to take volunteers who are willing. Who have allergies and are willing to take this under. Close medical supervision You know having an epi pen nearby having medical facilities nearby But seeing how they react to it and really studying that. I think the practical solution is bucket. Die with issue is not going to die until we have better data. It looks like the fda is probably in a position to recommend the people who are allergic to the components of this vaccine. Not take it But it doesn't look like they're going to recommend that everybody who has a serious allergy a peanut allergy for example. Not take it. Hey does the vaccine so far has been does it. Keep me from getting the virus in the first place or is it. Keep me from getting the symptoms of the virus. Because there's a difference right. Like if i'm getting but just i. I've seen fine great. But i can still pass it along to people. In that case right we have very little information about what happens to people who get to that scene and then we get exposed to covid nineteen. So that's a big open question. That also came up in the meeting. It was really interesting because you know they don't study whether or not people are transmitting it on the trial what they essentially do is they give half the people a placebo and half the people the vaccine and then they send them out in the world and they see who winds up with covance cut limited risk assessment that i think the uptake in the community is going to be fairly poor and that something better so one thing that pfizer said that they want to do going forward is to do these surveys. These blood surveys samples essentially to figure out who actually has the virus. And whether or not. You're transmitting it because as you said if you get the virus you might still be able to transmit even if you have the vaccine in your body is working to fight it off. So that's just sort of a big unknown right now. You know the thing that they all agreed on was that it was really effective and that they believed that it was very safe that there were not serious side effects to this too perlman. Your question about pregnant women. I you know i think there's a lot of unknowns with Pregnant women for example. They never studied it on pregnant women. You're correct that we have very limited data on using pregnancy We are expecting result of a developmental and reproductive toxicity. Study In the animal to be committed to we did hear the fda officials talk about possibly authorizing this vaccine allowing it to be used by pregnant women as long as they know the risks that it hasn't been studied in that population..
"pfizer" Discussed on Skimm This
"Okay at the top of the show. We told you about the big news this week. About pfizer's covid nineteen vaccine as regulators on both sides of the atlantic start approving it for distribution. But getting that vaccine from pfizer's labs to your arm isn't a straight shot. The vaccine still has a long journey ahead and has declare some pretty major hurdles world's toughest obstacle course. there are three main obstacles. The vaccine has to overcome before it actually makes. Its way to a human to help explain. We called up wendy zuckerman and i'm the host. Ap of science podcasts. From gimblett media zuckerman is a science journalist and she told us the first major challenge in the great vaccine. Obstacle course is temperature. The fis of vaccine needs to be cold. It needs to be so so cold and it needs to be cold for quite a while. Visors maxine actually needs. The thermostat turned all the way down to negative seventy degrees celsius or negative ninety four degrees fahrenheit. Let's colder winter in antarctica and definitely way colder than the freezer in your apartment. The reason the vaccine needs to be stored in that way is because of the technology pfizer used to create it m. r. n. a freshman bio pop quiz. Bets messenger are in a. m. r. which is the basis for the fis. Evac sane is very unstable is supposed to be in a body your body of viruses body. It's not ever really designed to be out in the world and so one way that scientists just sort of slow down. The process of degradation is just to make things very very cold. Visors labs may be perfectly equipped to feel like the south pole but the vaccine still need to make way around the world without overheating so this vaccines obstacle course. Goes back pretty much right to the point. When it's made it needs to go from the factory they will be putting in its little capsule. then it'll be put into glass tubes. The glass tubes obviously can't have any cracks in them. They kind of any faults in the middle. They have to be labeled correctly. And it's boring stuff like labeling that one academic from harvard was like things go wrong with labeling. Think about the jim in finance. Who gets labeling wrong that happens in pharmaceuticals as well. Yeah seriously come on. Jim finance then it needs to go onto the truck. They need to have these specialized refrigeration capability. So this is not your fraser at home. This is not even a kind of freezer. That a lot of labs have trucks lots of refrigeration capacity going into hospitals doctors offices all around the country. You think about your local doctor way you get your measles vaccination or you get your yellow fever vaccination. They're not gonna have these specialized refrigerators so they're either gonna need to get them all. We're going to have to have like vaccine hot spots where everyone will just go and stand in line. And they're going to be the places that are equipped basically everywhere from the trucks carrying the vaccine to. Your doctor's office will need to have special subzero capabilities. Btw visor knows. It's pretty unusual to have an ultra cold freezer on hand. So they're producing some transportable thermal boxes. That can store the vaccine for up to ten days. Still that may not be enough. People in the medical community have raised concerns about the cost of these special freezers said some hospitals especially roland that have been struggling financially. This year may not be able to afford them. And even if price isn't an issue these containers which will store between one thousand and five thousand doses of pfizer. Vaccines can only be open twice a day and for no more than three minutes each time longer than that and the vaccines could get to warm. So temperature is the first major hurdle in the great vaccine obstacle course. It has to stay cold for a really long time and that's way trickier than it sounds. But let's say are vaccine gets labeled properly is in a freezer box on a truck and is transported to a special cold chamber within a hospital or nursing home so far so good. We've reached our next challenge finding enough people who wanna receive it so that the us can reach herd immunity. Seems like this shouldn't be an issue right. you know. Global pandemic over a million deaths no cure and all of a sudden a vaccine. Finally right. well not everyone's on board in order to reach what's called herd immunity when a whole community is protected from the spread of disease. It's estimated that sixty to seventy percent of a country's population has to become immune that can happen either through vaccination or infection but hitting that herd. Immunity threshold requires a huge portion of the public to get vaccinated and lately. There's been a lot of concern that not enough. Americans will show up back in september. A pew research survey found close to half of respondents. Said they want to get a kobe. Backseat if it were available to them. I know there's been a lot of surveys showing very high rates of people who are not interested who is scared of taking the coronavirus vaccine but as time passes people seem to be warming up to getting vaccinated in november november follow-up pew found that the number of people who said that they wouldn't get an available vaccine had dropped to below forty percent. I think that number is going to go down because truly when they did a bunch of these surveys. We didn't have any data on this vaccine. So obviously even if you ask me. Super pro vaccine love him. I'd have posters and t shirts with wendy loves vaccines on them. But if i didn't have any data on what the side effects were and what the efficacy was and you asked me. You're going to take a coronavirus vaccine. I'd say i'm gonna wait data. I and time helps. Because as people watch other people getting vaccinated. they might be more willing to do the same jerseys. When we're gonna have a lot of these vaccines going to be able to get my vaccine in the next two weeks so people are going to have time to get comfortable with this vaccine as well. Here's the thing the government and the healthcare system. He'll wait for people to change their minds about the vaccine and they needed to get out there and start assuring the public that the vaccine is safe starting with making sure people have access to accurate information about the vaccine and how to get one and a good old photo op. Can't hurt either. Former presidents bill. Clinton george w bush and barack obama have all volunteered to get vaccinated on camera to prove. Say those efforts are all working towards one goal making sure the public has enough trust in the vaccine to hit that sixty seventy percent per immunity rate which brings us to our last hurdle. And unfortunately this challenge makes the job of convincing people to show for one vaccination look kinda easy by comparison year comes because we're the pfizer vaccine to be effective. It has to be distributed in two dosages and people can't get those doses at the same time. You've actually got to wait a few weeks in between which is a problem because people might be lining up.
"pfizer" Discussed on Coronacast
"So now let's talk about vaccines today. And i want to talk to you about a couple of different vaccines. But let's start in the uk where thousands of people in the last couple of days have received the fifa vaccine which is really exciting. But one of the things that we've heard about. Is that a couple of people have had an anaphylactic like reaction. So how worried should we be about that. People have been discussing this risk with the peiser vaccine because it uses a substance code peg polyethylene glycol mackerel goal and what this substance does in vaccine and a couple of vaccines that use it. I think the one of the meningitis vaccines may goco vaccines use. It is kind of out the components in the vaccine and enhances the immune response so essentially what you've got. Is you want the strongest immune response that you can possibly get here and the probably ethylene glycol helps that to happen. So that's what that's about so it does rarely 'cause <unk>. Reactions interestingly as pfizer says the didn't get an to or allergic responses anymore in the placebo in the anymore in the active group than the placebo group in the trial but these people certainly sound as if they got an nf electric or type reaction within a short time. After the you'd have to say was the pfizer vaccine. That did it. So you're saying that they did have some reports of these sorts of reactions during the trial but they didn't think it was caused by the vaccine. Yes and theoretic and people knew there was a theoretical risk of that because peg is known to cause an actual reactions in some people rarely. It's also used as a laxative. It's seems like a very versatile substance knows how to job well while we're talking about allergic reactions. Can we talk a bit about egg allergies and why we still hear that. If you've got an egg allergy that maybe might not have certain types of vaccine misleading story. That's got into the general public where they believe that if eggs have been used in the manufacture of vaccine. And you're allergic. You're going to get an egg allergy. It's not the egg itself. It's the embryo within the egg that they use embryonic cells within the egg that they use to actually make the vaccine. Influenza vaccine is the one which commonly uses eggs to culture the vaccine and it doesn't contain the york. Can we basically contains little or no egg allergen so it is a bit of a myth. So vaccine allergies are actually extremely rare. I mean some people argue that it's one in one point four million dollars what. Gp's are advised as you got a very egg allergy child them with a vaccine that uses egg. Then you just keep them in the surgery for a little bit longer just to make sure they're okay but a lot of these vaccines are being developed for. Covid have eggs anywhere in the process using all sorts of different new processes. The nova vaccine uses insect cells to produce the vaccine so lots of different selves used quickly. Talk also about china's vaccine which came out really quickly and they were reporting quite promising results. But there's been some news reports in a taiwanese news outlet saying that. Forty-seven people in uganda had the vaccine. Have now tested positive for coronavirus. How much stead should be placed on this news. Report a runabout about zero. We'd be my esteem you know. It's a newspaper. Report might be true. Might not be true. Might be misleading. That could have been part of a trial could have been in the placebo arm of the trial who knows and is complicated by the fact that no doubt taiwanese taiwanese media just love any story which knocks the chinese technological supremacy off the pedestal. So you just take all that with a pinch of salt. It may be true. But i'm really what we've to do. Chinese not done themselves a favor by not doing transparent trials at least yet and so we just don't know what's going on there and that sort of darkness stories like this popout and it. Just don't do the chinese any favors because the chinese are pretty good. Researchers of are some clouds hanging over some of their vaccine manufacturers allegations of fraud in the past. Well
"pfizer" Discussed on The Current
"Development has moved at lightning speed in the uk. On tuesday the first patients started receiving their shots and it looks like we will be seeing similar scenes in canada very soon yesterday. We got the news that the first covid nineteen vaccine has been approved by health canada. The me is amazed that we no one would have thought. I think even when we looked back at the first discovery of the of the virus that less than a year later we'd be authorizing and then distributing vaccine the superior sharma chief medical advisor to health canada speaking shortly before the vaccines approval. The vaccine is produced by pfizer and biotech and it uses a brand new technology in clinical trials. It showed efficacy rates close to ninety five percent. I spoke with call pinot president of pfizer candidate.
"pfizer" Discussed on Boston Public Radio Podcast
"We didn't take any money from while it's true. In terms of the development of the vaccine there was a carrot dangled out there two hundred million dollar federal. I'm sorry is it is it. is it two billion. How much money is two billion dollar early to buy of the vaccine and it seems to me again in the spirit of fairness it's an incentive for pfizer to do. Its work knowing that if they succeed. The federal government's going to give them two billion dollars for their work product. Isn't that fair yes. I think that's important to point out. It's not the same thing you gave us the money to develop tourists but yes it is and i think to give the administration. It's do they did. Try to build up funds and get ready to stockpile pay for this. There are many manufacturers including five zero ready made a lot of this stuff and have it in warehouses. Were very cold knowing that if it works. They're going to get paid. That was A reasonable approach. One thing we could fight about The administration bits so heavily in vaccines that they didn't spend enough money on research for medicines to treat people who get sick if you looked at the budget. It's like ninety percent vaccine funding in payment for a winners and maybe ten percent for medicines. Thorough diseases that we combat and control by using drugs. Thank hepatitis c. We don't have the vaccine but we got a pretty darn good medicine eight. We don't have a vaccine but we have pretty darn medicines now so you know there are people who say well they over bet on the vaccines. They put too much over there. But you know what's interesting about. This is the trump administration has been downplaying the virus throughout saying it's over when it's not it's disappearance. Not i mean. Obviously they did go go hot and heavy into the vaccine end of things which admits the problem. So it's a weird dichotomy there you know it is it is. It's true and look some other interesting things so pfizer has an early Announcement ahead of everybody else. But there's a almost the same kind of vaccine being developed by a company called madonna expenses. Here from then pretty fast. It's the same two-shot heavy refrigeration thing but it would add more access because it's just another company with bigger supply. The world is going to need a lot of vaccine so there's room for more than one company and so some people may get one vaccine and another group of people may get a different vaccine. And maybe they'll be slight differences on efficacy. You know maybe ones ninety percent or better and maybe ones eighty percent but that'll be interesting to see how that sorts out in terms of which one you know you get so to speak. I plan to get them. All actually decided. But i'm sorry mortgage. Who's going to say this vaccine. There was some controversy among evangelical..
"pfizer" Discussed on The Charlie Kirk Show
"Let's play cut. Twenty four of how morning joe on msnbc called the stock gains the quote biden rally. Play cut twenty four this morning. Oh dal futures rose more than four hundred and look at that easy to you. Know what they call that that the biden rally o- joe scarborough and despite the fact that pfizer held onto the news about the vaccine which should be investigated by the federal election commission and should be investigated criminally they said quote gruber said that pfizer and the bio and tech had decided in late october. That they wanted to drop the thirty two case interim analysis. The fda was of this decision discussions between the agency and the company's concluded and testing began this past wednesday. This means that the statistical strength of the result is likely far stronger than it was originally expected. They had this in late october and they decided not to announce it why we already went through. How pfizer some of the top democrat. Political donors out there. Pfizer directly interfered with this election as a publicly traded company because they wanted donald trump out of office. The milwaukee city wires shows preliminary milwaukee county election records. Show at least four. Felons and eligible to vote. Casted absentee ballots in the november third. General election says milwaukee felons cast absentee ballots in two thousand and twenty election. We already have evidence of what something that's happening. Wisconsin and the trump campaign staff claims to have statistical evidence of fraud in wisconsin as the president's path. The two hundred seventy electoral votes continues to narrow because of the new results. The washington examiner says one member of president. Trump's reelection team who spoke with the washington examiner on condition of anonymity said ballot ticket. Milwaukee indicates illegal activity by democrats in the city the distribution of those ballots in favor of presumptive president elect joe biden the individual. Edged violates bedford's law as we've talked about an analytical framework used by statisticians when observing a set of randomized data points bedford's laws often used by election analysts both the united states and abroad to detect fraud or any sorts of improprieties in elections in third world countries. They look at bedford's law if they're trying to steal. Any sort of election and voter fraud is rampant all across the planet as it is here and benfits law should be reason enough by the republican legislator in legislature and wisconsin and michigan arizona and pennsylvania. And georgia should open up a criminal investigation immediately or hearings and ask how is of this possible. Can show the bedford's law on the screen. So you see. This is a law of large numbers. And you can see in. The bottom right is biden's data's that right. I can't quite see what we're looking at. Their bottom right is biden's data. Ucla every one of those other charts seem to behave in the same manner. And yet when you stuff this philly milwaukee and detroit and when you interrupt a flow of randomness which is what happens when you do not interfere all the sudden. You're going to have data. That violates benford law. the bottom is biden's the top trumps see. How trump's behaves in a certain pattern. And you see how biden's does not again. This is a law of mathematics. This is not just some sort of conjecture..
"pfizer" Discussed on The Charlie Kirk Show
"And who from pfizer was calling the shots. Here we already said pfizer. Gave two hundred and fifty six thousand dollars joe by one hundred fifty thousand dollars to the democrat senatorial committee one hundred six thousand dollars to dc services and the ninety nine thousand the democrat congressional campaign committee..
"pfizer" Discussed on P&L With Pimm Fox and Lisa Abramowicz
"Wherever you listen to podcasts. On bloomberg dot com. So we have a lot of coronavirus news today. Most of it is positive. Well a mediation say most of it but some of it is positive. Let's say the vaccine being developed by pfizer and biotech is preventing more than ninety percent of domestic infections in a study of tens of thousands of volunteers. We also know. Madonna is getting closer however on the other side of things. We know that more than one hundred thousand. Us citizens will be diagnosed today and we just have mayor. Bill de blasio in new york saying new york city is coming dangerously close to a second wave with an already. now that is above two. Let's bring in max nielsen. Who can synthesize all this for us and tell us exactly where we are. He has farm analyst for bloomberg intelligence on bloomberg news. Max talk about the vaccine. The market is rallying big on it. Is it enough to save us on. Its own so this is what. I'd call really good news. That needs a lot of context. So that ninety percent result Really strong indication that this is going to be an effective vaccine could stayed overtime as you get more data a little bit lower but it really does suggest that this is something that that's going to work and be useful. Pa- caveat is that it's not gonna be immediately available and it's not gonna be broadly available for a longer time I think the company's guided to fifty million doses worldwide by the end of the year. I thought enough only twenty five million people manufacturing is going to ramp up over time. But you know it takes time and you will still need other vaccines to be successful. Likely in order to Get a significant part of the population. Just you know with any sort of any sort of reasonable timeframe. And the other thing to keep in mind is that it's not gonna be ready particularly in sufficient quantities to do anything about the current sort of rampant outbreaks..
"pfizer" Discussed on Z104
"Tell me what she name came with. Let's get a couple of phrase look like my, my extra Pfizer. The program. So. Kitchen. Minute. Oh. Maybe let me put. I'm a big. I don't know. There's something in a way you Rollier is. Takes me back to pad or. Everything is good. The only thing that's good. China..
"pfizer" Discussed on News Radio 920 AM
"That Probably going to, get away, with. It but man enemies I'm gonna get it. Back to the phones people who are waiting a long time here and I haven't gotten. To enough of you, it's. Jerry in. Temperance Michigan welcome sir great. To have you, here. Great staff here rush reason I called is We have you know there have been really really silent I now they should. Know that they've been, lied. To and. I don't think there's any. Shelter that would. Put. Up with BMI too You see, you would think you, would think. They know they've been lied to but we don't know, that they know that common sense fails I can't tell you how many times I have the same? Question as, you if they know if they know they've been lied to what, are they doing about it or what are they gonna do. About what will they do about it Or do they even care in Pfizer Pfizer warrants many people say become rubber-stamping for the most part over the years But if if what we think, happened if this dossier was Primo evidence number one and if it's totally. Made up and the judges were. Not told it's nothing more than Clinton campaign research that it was not legitimate Intel I would think they'd be livid I would think they would be just livid at, having been lied to us this way and what some. Now there is an inspector general investigation of this going on and I'm sure the Pfizer judges are.