5 Burst results for "Peter Mccallum"
The Financial Guys
"peter mccallum" Discussed on The Financial Guys
"People like me, doctor Scott Atlas, doctor Peter McCallum. We were giving these people data for three. I wrote on directly Redfield while I was in the administration with the defense science daily as it came to me. They could never see it. They never knew anything. We gave it to them. The problem here is the incentivize. Then Santa wise by doctors, the medical, we are in this position today because of medical doctors around the world, especially in America. They refuse to stand up because they were incentivized by item and keeping their jobs or threatened. They refused to stand up to use early treatment. They had the government selling fraud about lockdowns. Doctors helped government selling fraud about these gene injections, achy, vaccines. They lied to the public. Doctors have no credibility anymore. Zero. No one trusts them. And they earn that lack of respect because then their actions cause the deaths of people and what you just said about that reason study by shakshuka. I noticed study shows that your three times are more risk. More than three times the more doses of vaccine you get greater than three doses. It's a devastating study because it really shows the vaccine divide the element booster where they are pushing on you now on children. It's based on a study of 8 mice. Not human details, animal data, rural data, but just eat mice and these vasters want to vaccinate 200 million Americans. 8 months. And I can tell you, I studied the data, the 8 mice got sick, the lungs got infected. In other words, this trial that they're using to get emergency use that they got from FDA, the actual mice got sick. You should not even approve it. Not even the mice made it. But this is serious though, to your point, doctor, like, I don't trust the Doc, my medical industry. Because in all honesty, now that I realized with COVID and no disrespect to the medical community, but
Science Friction
"peter mccallum" Discussed on Science Friction
"Create as x-rays bombarded it. So it's kind of like a negative image really. And so those numbers are deposited in a repository called the protein database and what I do is I take those coordinates and I bring them into my software and then that produces a 3D structure of whatever it is I'm interested in DNA or protein. What are you doing here? What are you animating? So our first animation, which was our flagship animation is called what goes wrong in cancer. And that's like a tour de force kind of overview of the mechanisms that can lead to cancer. Typically starting with DNA damage. We're subjected to forces in the environment that damage our DNA in our cells, sunlight, food, stress, chemicals, exactly. We're subjected to those things on a daily basis. And they cause damage to the DNA in our cells. And we have to have mechanisms in place that detect that damage. One of those particular structures is called P 53 and there are a number of people working on P 53 at the Peter McCallum cancer center because it is like a sentinel protein. It can actually detect and find DNA damage. And then it makes a decision based on that damage. How severe it is, whether it will slight the cell for destruction, or whether the DNA can be repaired, and then it calls in all these other pieces of cellular machinery that will then undergo the DNA repair process. It is known as the guardian of the genome. Interestingly, in cancer, P 53 is defective in about 50% of all cancers. So it's a really big player. And so what happens is you have an accumulation of DNA damage within that cell. And then combined with other factors. That can make that cell malignant. And it can start dividing out of control, which is then the advent of a cancerous situation. That is the drama of cancer that you are actually animating. So you can see here, this is magnification 4 million times inside a cell nucleus. So we've gone right inside. Oh, look at that. So you can see strings of DNA twisted as a double helix, which people are familiar with. Yes. You've made them light, blue, purple, green, yellow, and pink. And then this kind of other brought orangey pinky, so that's pay 53. So what is it doing right there? So it's come along the string of DNA, and it's found its special binding site, that it's locked onto specifically. And it's just sent a message to repair or destroy. Everything is moving. There's a real dance to this DNA. You have to kind of realize that molecules are not concrete. They are soft and they wiggle around with what's known as brownian motion. So yeah, they're constantly jiggling moving, wobbling around. And this kind of enables them to make contact with each other and with the molecules that they need to interact with to do their job. So yes, the structures are all based in data. What you see is how they are. However, the colors that I use complete artistic license. You do have to make strict decisions about what you choose to leave in and what you choose to leave out. The cell is a molecular soup full of thousands of molecules, all interacting at once. And if you were to try and display all of those, the viewer would have no idea what it is you're trying, the point you're trying to make. Myra are these animations also, can they change the way scientists understand or think about the problems they're trying to solve at the molecular level? Have there been revelations? That they couldn't have imagined without the help of a visual moving dramatic representation of what they're working with. Definitely. Often when they see the structures after I've built them. They sort of say, oh, didn't really imagine that it looked like that. And it has the power to take their research in different directions. Has it shifted your own understanding of cancer? Or your own perceptions of cancer? It has. When my own husband developed cancer, people were so sort of sympathetic and felt that I must be completely devastated by this. And I was. But at the same time, I knew he was in such good hands and I knew that he would come out of it and that he would be okay. And he was. There's so much going on and there's so much great research out there and so many fantastic treatments that are helping to combat this or what used to be an invisible killer. That's changing now. In some sense, you know this disease more intimately than most because you've had to climb inside its mechanics inside the cell. It does give me quite a privileged view on what's going on because as you say, I get to actually interrogate these molecules I get to put them in software, walk around them, spin them around, turn them upside down, have them interact with other molecules. So yeah, you become quite intimately involved with them and attached to them. And I think with that sort of intimate knowledge, it takes away the fear of cancer and because we know what some of these molecules are doing and how they work and why they're important. We can do our best to work with those. And find out ways around them. Thankfully, the machinery inside ourselves mostly works for us, not against us, and there's an incredible artistry to how it all functions, that artistry in nature, but first captivated Meyer as a child. That's what I want to bring to people. It's so complex and gorgeous. I think if people realize that it was there that they would have a much greater respect for their bodies and their biology and would make a much more considered effort to look after themselves. And also have a much clearer understanding of why things go wrong in situations like cancer. Maya, thank you so much for joining me. And telling me what you do. Thanks a touch. It's been a pleasure. Doctor Mayer biomedical animator at the paina McCallum cancer center in Melbourne. And I'm wondering if you're a scientist who has made a career out of art instead or found a way of marrying the two. I would really love to hear from you, get in touch via the science friction website, or you can find me on Twitter at Natasha Mitchell. Share the podcast, spread the word, leave us a review on Apple podcasts, too, if you get a chance, it really helps others find us. And I'll catch you next week. Have a good one. Bye. You've been listening to an ABC podcast, discover more great ABC podcasts, live radio, and exclusives on the ABC listen app..
Science Friction
"peter mccallum" Discussed on Science Friction
"Me. What is it about that era of fashion? 40s 50s 60s? I like 50s for daywear because it's quite demure and can be quite conservative but also glamorous and I love 60s for evening wear. It's quite daring. I think it was a time of great kind of design innovation and the rise of feminism as well. And the way women raised their hemlines and took off their bras and did whatever they wanted. But the 50s wasn't like that. The 50s women were still constrained and some of the fashion you wish. It's absolutely stunning, but my question is how do you reconcile that with the kind of strong contemporary scientist, a woman with a PhD now? Yeah, you're right. A lot of 50 fashion can be quite constrained and corseted and quite structured. I don't know, I think something about the feminine of it, I find quite powerful. That's a source of strength and that's the source of power. I certainly don't wear the corsets from the 50s. That's for sure. I do like to be comfortable. So she was expressing a self creatively outside of work through fashion and flamenco. But after years in sales, she started to ache for a more creative career, too. And that's what we're exploring in this scratch that each series here on IBC radio national science friction. People who find a way of using their scientific training to become artists for Meyer, it was a chance conversation that changed the course of her life. So I just randomly expressed my frustration to one of the receptionists at way high one day. The Walter and Eliza hall institute. Yes, that was part of my sales patch at the time. And I was there visiting and I just said to her, I look up just really need more creativity in my life and I'm trying to think of a way of bringing art and science together and I don't know how to do it. And she just said, oh, you need to meet drew. And so she turned around, walked through a door and then dragged this out of his office. And he introduced us. He was Dr. Drew Barry. I biomedical animation. The way high. This is a guy who's won Emmys for his animations. He's one Amy's and Beth is and he's a scientist. He comes from a cell biology and microscopy background. Yeah, then became the kind of the Photoshop guy and then he approached the director at the time and said, oh, you know, I'd really like to try this animation gig. And she said, yeah, go for it. And so he developed that whole idea really. He's a real pioneer in the field. And he's considered the world's leading exponent of the art form and so yeah, I met him and he showed me his beautiful, beautiful work and I just was blown away by it and thought that seat. That's exactly what I need to do. Dr. Drew Barry became Myers mentor. She said about doing a multimedia and design course at Swinburne university, built up her portfolio, used it to get into the competitive animation course at the Australian film television and radio school. And she hasn't looked back. She is now an award winning biomedical animator, so she brings to life. The teeny tiny world of the molecules inside your cells, the proteins, the DNA, to help scientists and patients. At the Peter McCallum cancer center, understand what goes wrong in cancer and how new treatments might work. Your animating the processes that occur inside our cells in cancer. Cancer is a sinister thing. I mean, it's just biology, but it's also deadly. It's distressing. And so how do you think about that when you're creating what looks like a really beautiful process, you know? It's colorful. There's an aesthetic to it. You're dealing with something quite grim. Yeah, one of my friends said to me, are you making cancer look so pretty? You make disease look so pretty. On the one hand, I thought, oh wow, that's great. And then on the other hand, I thought, you know, is it really appropriate to make something that people find uniquely terrifying? Look beautiful. But then I thought, what I'm really hoping is that the color and the beauty of the landscape actually is making a comment about the complexity of the molecules themselves and how they're interacting. I hope they do is that they can give people a sense of optimism about where cancer research is going. I think people have traditionally had this idea that cancer is a monster. And there's nothing we can do about it. And you can just curl up in a ball in the corner and die. But I think people are probably failing on a way that scientists are making great inroads into understanding mechanisms of cancer. And this is a time of great optimism in cancer research. We've got these incredible new treatments such as chimeric antigen receptor T cell therapy, in which you can actually genetically engineer modify a patient's own immune cells to seek out and specifically destroy cancer cells. Traditionally scientists have not been all that great at explaining to the lay audience what it is that they do. And that's what animation does, because it unfolds before your very eyes. At the moment, we're actually developing a resource for use in the clinic to explain to lung cancer patients about a mutation that causes their cancer. We're going to use this in the clinic to show it to them and to explain exactly where this little pinpoint is, where it goes wrong. And then we're going to explain how a new medication can be used to actually interrupt that mutation and to get around it. That might help them make decisions about whether they want to be involved in clinical trials or not to test that particular medication. Where do you start to animate something that we can not see directly? I mean, even scientists. They have to use instruments to probe in the dark. But even then it's sort of abstract, isn't it? Give people a sense of that. You can only really see molecules with an electron microscope. And the images are built up from stacks of images, so like little slices through the molecules that you then have to kind of stack together to build a 3D image. The other way that you can actually determine the shape of molecules is with x-ray crystallography. And that involves bombarding your molecule with x-rays and then the trajectory that the x-rays take as they make contact and then bounce off the molecule. So the XYZ coordinates in space tell you the shape and the volume of the structure. So you're not saying that structure directly, you're actually just saying the scatter pattern that the structure would.
Science Friction
"peter mccallum" Discussed on Science Friction
"An ABC podcast today, doctor Paul Johnson is a Professor of medicine at the university of Melbourne, among other roles. But back in 1993, he was a young physician, working at the Fairfield infectious diseases hospital in inner Melbourne. And it was a personal connection that would set off everything that came next. Our family had just bought a holiday House in east cows in a region called silver leaves. And that's because, unfortunately, my dad died relatively young and he's leftovers sabbatical. My mom and my wife and myself got together and we bought this house as a memorial almost to him because he used to love going down there, but he only ever had the chance to rent. We weren't that well often we were kids. Cows is the main township on Philip island. A beach holiday spot two hours drive southeast of Melbourne. The island's usual claim to fame is the local population of little penguins. But this was a different story. All of a sudden, I was seeing people at the Fairfield infectious diseases hospital in the central Melbourne. Who seemed to have these rather horrible ulcers and their street addresses were quite similar or in the same area as we just bought this house. A handful of patients was presenting to the hospital with these severe skin lesions that refused to heal. These often appeared as a bull's eye wound, quite deep, red, and pustules at the center with weakens surrounding skin. Paul started to investigate these cases, more closely. I put a little group together and we started having a look around. And we found that there are clustering around the golf course, so all of the people who had cases, if you draw them on a map, they all seem to cluster around the golf course and that swampy area near the golf course. Whereas, on the other side of cows, which otherwise was similar, there was no cases at all. So it was extremely local. At the time, Paul had been searching around for a research project to sink his teeth into. And here it was. Mysterious ulcers, popping up in this one sleepy beach town. And as he soon finds out, this mysterious disease, it does have a name. Actually, it has a few. So it used to be called bean style also in Victoria. And it's been called daintree ulcer in mosman ulcer and far north Queensland. It's been called sick belong a cpac and New Guinea and the name beru also actually comes from East Africa. But the reason there are so many local names is because people realize this very local characteristic that you get it in certain places. And it's this last one that the World Health Organization would decide on as the diseases official name. Paul was going to investigate beru ulcer. And he wasn't going to do it alone. I'm Elizabeth cool ass, welcome to science friction. Are we seeing infinitesimally Mitchell for a couple more weeks? And today on the show, how a sideline research project would turn into a 25 year collaboration to figure out how brulee also functions and how it spreads. It's like a really interesting, almost murder investigation. And this Odyssey, it's really a parable for how science works. And often finding something isn't the way you thought it was, it's much more helpful. But now after a quarter century, two Melbourne scientists are getting very close to some answers. Okay, Paul, before we get into the mysteries of what we don't know, let's get into what we do know. Would you describe what it is we know about the bory ulcer and how it functions. So it's basically an environmentally acquired infection of the skin. Basically something happens to you when you go into an environment where the bacteria is and for many years it's been a mystery where it is in the environment and how you get it when you're there. And really interestingly, it seems to only take an afternoon or an hour even in what we call an endemic area to become at risk of acquiring it. And if you do acquire the infection, it can often be very hard to tell. It's got a very long incubation period. So it may be many months before you notice anything. And typically you notice a small growing thing that we call a lesion and it keeps growing. And it doesn't usually hurt too much. But it just relentlessly progresses. Over the years, doctors like Paul have pieced together the movements of people visiting endemic areas for short stretches of time. Things like going to Philip island for a day trip. And they figured out that there's usually a four or 5 month lag between assumed exposure to the bacteria, and the first presentation of an ulcer. In some cases, that can take 9 or ten months. So you've got no idea it's there, and it gives the infection heaps of time to grow. And now, if left, it can become very destructive slowly. It kind of spreads quite widely in the fat layer between the skin and the lining over the top of the muscles and the bone. So in that space between skin and the deeper structures. And also that you eventually see on the surface, which may not be there initially, is really like the middle of a donut, so you see a hole in your skin appearing, but the problem is already quite a lot bigger and gone well beyond what you can see. So what's on the surface is a kind of tip of the iceberg. It can be typically in the disease family trait, baruch also is closely related to leprosy and tuberculosis. Cases were usually found in tropical, rural areas of West African countries. Places like Ghana, Côte d’Ivoire, Benin. Left untreated, the legions can grow so be that people are left with terrible scarring or can lose the function of a limb. So when the disease presents in Victoria, it's something of a fantastic paradox as Paul puts it. Meanwhile, here we are in Victoria. We've now got one of the highest rates in the world. And we are seeing it in fully developed country in urban and suburban settings. And yet people are turning up in the winter to their doctors with a tropical disease occurring in a temperate part of the world. So that's the paradox. The reason it turns up in the winter is because of this long incubation period and people do get infected in the summer. But the fact that we've got a tropical rural disease in a temperate first world city is really interesting. In Australia, the first recorded case of beru ulcer occurred in the 1940s in bendale, a small town about 300 kilometers east of Melbourne. Not long after that, a group of Australian scientists, including sir Peter McCallum. They identify the bacterium that causes the disease. Mycobacterium ulcer or M also runs for short. They have also been small case clusters around the daintree river in far north Queensland, and some near rockhampton. But for decades, they were just a few cases each year. Then, across three years in the early 90s, 29 cases emerged around that one golf course in Phillip island. This had been an infectious disease, rare enough and dispersed enough, but no one had paid too much attention, except for a small number of dedicated researchers..
America First with Sebastian Gorka Podcast
"peter mccallum" Discussed on America First with Sebastian Gorka Podcast
"Let's go to mark who's been waiting very patiently in new jersey mark. Welcome to america. I thank you dr gorka and congratulations to our british cousins poor declaring their freedom and to the parents of our country for pushing back at school board meetings of this critic. Crt critical child. I'm sorry critical race theory which is child abuse. But my point is this Speaking of a crime as mr biden is going to address crime. It's out of control. In every democrat city. A thirty one year old female graduate student of criminology was just stay up to death in chicago where police are not allowed to chase the criminals. Courtesy of ms lightfoot lori life with the police policy and biden and harris has failed sir. They have failed in their primary duty of protecting the people of our country by knowingly knowingly leading in and deliberately allowing criminals drug dealers and spent little drugs to come over our border over the mexican border on checked and killing innocent americans and hurting them not only. Why should anybody be surprised. We're talking about an individual in the personage of the current vice president who helped fund raise for the violent radicals of black lives matter antifa. They have no respect. You want just a number. You're just a tax payer and if you are republican you are the enemy to these people and yes you are right mark. They are endangering all of us but we will not let them get away with it next to the patriots from the loudon county. School board meeting and dr peter mccallum here on america focus..