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"north adelaide australia" Discussed on NEJM This Week - Audio Summaries

NEJM This Week - Audio Summaries

08:49 min | 1 year ago

"north adelaide australia" Discussed on NEJM This Week - Audio Summaries

"Vaccine Foresee men be was introduced in the United Kingdom as part of the publicly funded infant vaccination program these investigators assess the effect of this vaccination on the incidents of Manila Cockle Group B. Disease Four for C. men be uptake in England remained consistently high data from the first three months of twenty eighteen. Showed that ninety two point. Five percent send children had completed the primary immunizations by their first birthday and eighty seven point. Nine percent had received all three doses by two who years from September. Twenty fifteen through August twenty eighteen. The incidents of Meningococcal Group B. Disease in England was significantly mificantly lower in vaccine eligible cohorts then the expected incidents sixty three observed cases as compared with two hundred fifty fifty three expected cases with a seventy five percent reduction in age groups that were fully eligible for vaccination the adjusted vaccine affective nece against meningococcal groupie disease was fifty two point seven percent with a two dose priming schedule for infants and fifty nine point point one percent with a two dose priming schedule plus a booster at one year over the three year period. There were one hundred sixty. Nine cases of of meningococcal groupie disease in the vaccine eligible cohorts and an estimated two hundred seventy seven cases were prevented the foresee I see men be program was associated with continued positive effect against meningococcal groupie disease in children in England and Protection Shen after three doses of the vaccine was sustained for at least two years meningococcal B. Vaccine and meningococcal carriage in adolescence in Australia by Helen Marshall from the women's and children's Health Network North Adelaide Australia the role all of the new meningococcal group B. Vaccine Foresee men be in preventing transmission and therefore inducing population heard protection and is uncertain in this study the investigators used cluster. Random is Asian to assign according to school students in years. Ten to twelve age fifteen fifteen to eighteen years in South Australia to receive foresee men be vaccination either at baseline intervention or at twelve months. Wants control a total of two hundred thirty seven schools participated at twelve months. There was no difference in the prevalence of carriage of disease is causing end meningitis. Between the vaccination group two point five percent and the control group two point five two percent there were no significant significant differences in the secondary carriage comes at baseline the risk factors for carriage of disease causing end meningitis included later later year of schooling current upper respiratory tract infection cigarette. Smoking waterpipes smoking attending pubs or clubs and intimate kissing. No vaccine safety concerns were identified among Australian adolescence. The foresee men be vaccine had no discernible effect. act on the carriage of disease causing meningococcus CY including Groupie Lee Harrison from the University of Pittsburgh writes in an editorial to`real that the results of the study by Hani and colleagues suggest a substantial effect of foresee men be on capsule or invasive meningococcal group group-b disease in children in the United Kingdom. This is good news and highlights the real world effectiveness of foresee men be in the study by Marshall Dylan colleagues. No appreciable effect of foresee men be on the prevalence of carriage or the acquisition of strains of any capsule or group including meningococcal an injured cockle group B was detected. The lack of heard protection conferred by foresee men be against encapsulated meningococcus. I is the bad news. What are the implications of these results? For Policies on meningococcal immunization first three doses of foresee men be provided approximately oximately sixty percent protection against invasive meningococcal group B. Disease in infants. This provides assurance of effectiveness through immunization station programs by extension and on the basis of other studies cited by lead honey foresee men be is probably effective in other age groups such such as adolescence and for control of outbreaks caused by meningococcal strains that are covered by the vaccine second foresee men be does not provide heard protection against encapsulated meningococcus site so it will protect only persons who are adequately immunized it has taken decades aides of research and development to finally have licensed manindra cockle groupie. Vaccines The studies in this issue. Underscored the major progress that has has been made however they also highlight the need for improved meningococcal group B. Vaccines L. A.. GOLIC's thanks for heavy menstrual bleeding in women with uterine fibroids by William Shlef from Thomas Jefferson University Philadelphia Uterine. Uterine fibroids are hormone responsive neoplasms that are associated with heavy menstrual bleeding into identical randomized. six-month month phase three trials Ella golic's an oral nat atropine. Releasing hormone antagonist was administered with hormonal. Add back therapy Ester dial one milligram norethindrone Acetate zero point five milligrams once-daily in women with fibroid associated bleeding. The primary endpoint was menstrual. Blood loss of less than eighty milliliters during the final month of treatment and at least a fifty percent reduction in menstrual blood blood loss from baseline to the final month criteria for the primary endpoint were met in sixty eight point. Five percent of two hundred six women in the first trial and in seventy six point. Five percent of one hundred eighty nine women in the second trial who received Ella Golic's plus add back therapy as compared with eight point seven percent of one hundred two women and ten percent of ninety four women respectively who received placebo among among the women. Who received Ella Golic's alone? The primary endpoint was met in eighty. Four point one percent of one hundred four women in the first trial and in and seventy seven percent of ninety five women in the second trial hot flushes in both trials and metro. Raja in the first trial occurred significantly more commonly with L. Golic's plus add back therapy than with Placebo Hypo allergenic effects of Ella. GOLIC's especially decreases. In in bone mineral density were attenuated with add back therapy ella. GOLIC's with add back. Therapy was effective. In reducing heavy menstrual bleeding reading in women with uterine fibroids tempera to Munib for the treatment of active thyroid eye disease by Raymond. Douglas Douglas From cedars-sinai Medical Center Los Angeles thyroid eye disease is a debilitating disfiguring and potentially blinding being peri ocular condition for which no FDA approved medical therapy is available. Strong evidence has implicated the insulin. Like like growth factor. One receptor I. G. F. One are in the pathogenesis of this disease in his face. Three trial eighty three patients with active active thyroid eye. Disease were randomly assigned to receive intravenous infusions of the I. G. F. One are inhibitor. TEPPO tomb you MAB OR PLACEBO CBO once every three weeks for twenty one weeks at week. Twenty four the percentage of patients with prosise response was higher with TAP Wpro to me Mab than with Placebo. Eighty three percent of patients versus ten percent with a number needed to treat of one point. Three six all all secondary outcomes were significantly better with tempo to Mab than with placebo including overall response clinical activity score of zero or one.

Ella golic England GOLIC United Kingdom Manila Cockle Group upper respiratory tract infect South Australia Helen Marshall Lee Harrison Marshall Dylan Thomas Jefferson University Ph TAP Wpro Australia Health Network North Adelaide B. Vaccines norethindrone Acetate Munib Douglas Douglas Hani cedars-sinai Medical Center Lo