19 Burst results for "Nicotinamide"
"nicotinamide" Discussed on The Radiant Health Show
"<Music> Yeah <Speech_Music_Female> I'm just I'm <Music> just thinking when you're talking <Speech_Music_Female> about you. Know obviously <Speech_Music_Female> stresses <Speech_Music_Female> You know <Speech_Music_Male> thing that causes <Speech_Music_Female> all sorts of metabolic <Speech_Music_Female> problems in <Speech_Female> right now. <Speech_Music_Female> She's a piece <Speech_Male> this <Speech_Male> is. <Speech_Female> <Speech_Music_Female> Stresses <Speech_Female> Sane Yeah. <Silence> <SpeakerChange> <Speech_Male> Yeah, <Speech_Male> it really <Speech_Male> is and big <Speech_Male> for a lot of people <Speech_Male> they don't understand. <Speech_Male> Why do I <Speech_Music_Male> wanna through <Speech_Male> baggage or KIA <Speech_Male> chips when I get home <Speech_Male> from work if I'm working, <Speech_Male> I <Speech_Male> look at that Tortilla <Speech_Male> chip bag. I almost <Speech_Male> want to hug it. <Speech_Male> You know it's <Speech_Male> like. It's <Speech_Male> all that salt. <Speech_Male> My want that <Speech_Male> crunch and <Speech_Male> you know they'll eat <Speech_Male> pass being full <Speech_Male> right, they'll. They <Speech_Male> won't be able to stop <Speech_Male> because their brain. <Speech_Male> Saying no, <Speech_Male> your belly might be fooled, <Speech_Male> but I'm not <Silence> satisfied yet <Speech_Male> and. <Speech_Male> Getting people understand <Speech_Male> the impact, <Speech_Male> you're not week. <Speech_Male> If you're under stress, <Speech_Male> it's <Speech_Male> understanding that <Speech_Male> you you may have <Speech_Male> a different senior digestion. <Speech_Male> A lot <Speech_Male> of people don't realize if <Speech_Male> you have insomnia. <Speech_Male> It's a disorder <Speech_Male> of hyper <Speech_Male> arousal meaning. <Speech_Male> Your brain took <Speech_Male> on too much stress during <Speech_Male> the day, <Speech_Male> and it couldn't unloaded <Speech_Male> it night <Speech_Male> and now <Speech_Male> has thinks it <Speech_Male> has to be at high alert <Speech_Male> at night, and <Speech_Male> so we need to do a better <Speech_Male> job at trying to help people <Speech_Male> to calm down and not <Silence> just give him an axe, <Speech_Male> or give <Speech_Male> 'em PROZAC or <Speech_Male> give them something you know, <Speech_Male> something you. <Speech_Male> Kinda <Speech_Male> quiet <Speech_Male> the ship. Let's <Speech_Male> teach them <Speech_Male> breathing. <Speech_Male> Give them nutrients <Speech_Male> like CNN <Speech_Male> or Laura <Speech_Male> or holy. Basil <Speech_Male> that help them <Speech_Male> calm down at night, but don't <Speech_Male> have such A. <Speech_Male> Such a <Speech_Male> high side effect profile <Speech_Male> and and <Speech_Male> get them to learn <Speech_Male> to manage their <Silence> day. <SpeakerChange> <Speech_Female> <Speech_Music_Female> Yep <Speech_Music_Female> absolutely <Speech_Female> can't can't agree <Speech_Female> more, so <Speech_Female> we have two minutes <Speech_Female> left, so is <Speech_Music_Female> there anything <Speech_Music_Female> that we didn't talk about? <Speech_Female> She <hes> <Silence> that. <Speech_Male> First of all. <Speech_Male> They're interested in metabolic. <Speech_Male> Oh, they can go to metabolic <Speech_Male> code DOT COM <Speech_Music_Male> or if they want to hear <Speech_Male> more about what <Speech_Male> what I'm doing out <Speech_Male> in the Industry Jim Lavalle <Speech_Male> Dot Com <Speech_Male> I. Think it's important <Speech_Male> for people understand <Speech_Male> no one's GONNA. <Speech_Male> Take your of your health <Speech_Male> benefits than <Speech_Male> you are, and <Speech_Male> no one will be bigger <Speech_Male> advocate. You know <Speech_Male> there's A. A lot of people out <Speech_Male> there like the <Speech_Male> care about people <Speech_Male> want them to <Silence> do their best, <Speech_Male> but it's <Speech_Male> individual <Speech_Male> responsibility to <Speech_Male> take that first step that <Speech_Male> matters, and I encourage <Speech_Male> everyone to be <Speech_Male> brave. It's <Speech_Male> work, but <Speech_Male> it's worth it. <Speech_Male> It's slogan I <Speech_Male> use nowadays that the <Speech_Male> explain <Speech_Male> no work around <Speech_Male> your health. It's work, <Speech_Male> but it's worth it because <Speech_Male> everybody <SpeakerChange> likes to feel <Speech_Female> good. <Speech_Music_Female> Yeah! <Speech_Music_Female> <Speech_Music_Female> That's for <Speech_Female> sure and you you're. <Speech_Male> More than likely. <Speech_Male> Your family <Speech_Music_Female> doctor is not <Speech_Music_Female> the person who's GonNa. <Speech_Music_Female> You know really teach <Speech_Music_Female> you about how to create. <Speech_Female> How I, always <Speech_Music_Female> say. I learned nothing <Speech_Music_Female> about health <Speech_Music_Female> when I was in medical <Speech_Music_Female> school or residency, <Speech_Music_Female> and it wasn't <Speech_Music_Female> until you know <Speech_Music_Female> after I, got out. <Speech_Music_Female> <Speech_Music_Female> <Speech_Music_Female> I learned your data <Speech_Music_Female> I was like wow. <Speech_Music_Female> <Speech_Female> Who actually knew how to <Speech_Female> create health and they <Speech_Music_Female> know how to <SpeakerChange> do that before. <Speech_Music_Female> <Speech_Male> <Speech_Telephony_Male> <Speech_Male> Exactly <Speech_Male> right <Speech_Female> yeah. <Speech_Female> Thanks so <Speech_Music_Female> much for being on my show <Speech_Music_Female> again. You're just a <Speech_Music_Female> wealth of incredible <Speech_Music_Female> information <Speech_Music_Male> and <hes> <Speech_Music_Male> just really appreciate <Music>
"nicotinamide" Discussed on The Radiant Health Show
"You would recommend to more specific for their particular institution. That's exactly right. So what you do is, you'll start off with. steph generates a report. So you get this really thorough report. It's about a forty five page report that goes through every lab. That's out of balance meaning cheater, trending higher low or out of bounce higher explains that any group solve the data into those groupings of you know adrenal thyroid pancreas. What I? I found. Is that people get confused when you when you show him elapsed and you're right in little notes on every page. What each one of those lab values me by the time they get to the like the third pays or I. Don't remember any of this. What we did was regrouped everything into five groups, and you're either in the green, yellow or the red. And all of the scores of populate into those areas, so it's easier to begin to educate people, but it's a pretty sophisticated lab test to start, and then yes, you could break out into other more appropriate tested you more indepth research for example that was auto immunity and you had to do like you know auto immune markers for Lupus or something like that that stuff that you would do when you're interviewing them and you see them. Maybe they've got a diagnosis, or maybe you. You pick up on something and you need to ask him about it. But I think the biggest thing that we still don't have is. A lot of times, people don't even know the basic things that they should do. and. That's the first start like a red blood cell magnesium as a way better way to measure your magnesium status than a serum magnesium, and you can get rid what so magnesium it leading labs, but people don't do. That often and magnesium once again core nutrient big big problems in the US because people don't eat vegetables don't have magnesium. It's essential nutrients gonNA. Cost problems, so pick up on all that. So Do you have any any insurance and said cover? The services that you do for. Is it out of pocket? Well all the all of like retraining physicians now all over that kind of all over the country, so all the labs because they are traditional labs and people are usually coming in with problems they are covered by their insurance. Right if they need a lab test, these are lab that aren't unusual for a for an insurance company cover. And then it's up to the doctor, so a doctors trained in it or for ourselves If people want to come in, they can either be insurance now, like hey. I accept insurance and I'M GONNA. Do Your you all of this that often your insurance co pay is going to be fine, or it can be a gas scenario where the point in saying. Hey I'm working with you more. Is Your coach and I'm taking an hour of time to go over this and plan your program, and it's more of a cash based situation and we have. We have healthcare providers. Nurse Practitioners doctors that do both. Like some of them are more cast. Pay Some more insurance based we're. We're just trying to get the message out that. We think people need to empower themselves. And be their best advocate for their help learn how for your away from your your best good and learn about your metabolism. Your metabolism just isn't faster slow. It's about what you do every day I mean let let's think about it. I have to be reminded debris through acid watch. About that. Right I mean we're. You know we. We've gotTA. Have things. Remind us that we need to breathe deeply. That's when you were were under a pre stressful state of being in in the United. States right now and really globally now and great. I bring awareness to that..
Why An Experimental Therapy for Inflammatory Disorders Could Help the Fight Against COVID-19
"Joe. Thanks for joining us. Joe. Thanks To be for here joining thing us. we're going to To talk be here about thing Aqua Lung Therapeutics we're going to talk about Acute Aqua Respiratory Lung Therapeutics Distress Syndrome Acute or arts Respiratory Distress and your Syndrome efforts or to arts develop a treatment and your for efforts this condition. to develop a treatment Let's for start this condition. with ours though. Let's What start is with it ours and though. how big What a health is challenge? it and how Does big it represent a health challenge? Does it represent about half a million people. about Every year get half air a million people. F- Every Acute year Respiratory get Distress air Syndrome F- Acute Respiratory in the Distress United States Syndrome alone. And in you know the United close States to alone. two million. And Maybe you know globally close to two million. so it's Maybe globally it's not a so uncommon it's it's not a uncommon Disorder Disorder But it is a extremely But it is challenging a to extremely treat disorder challenging because mortality to treat of this. disorder because mortality Anyone that of this. had gets a yard Anyone that had is gets Thirty a yard to forty percents is In Thirty the US to forty and percents it's probably In the higher US and it's probably Outside the US higher what Outside makes the it US so challenging to what treat? makes it so challenging Well to treat? it's It's sort Well of the ultimate it's in inch It's sort of in the ultimate the stress in to inch in the To stress to a human being To in that a human being They have in that multiple They attacks have on multiple attacks a variety of on Oregon a starting variety with of the Oregon lung though starting the the most with the common lung causes of though ARD the the s most are common causes sepsis of ARD which is s infection are in sepsis the bloodstream which is infection and trauma in the bloodstream and and trauma Smoking and elation will do it Smoking and elation will do that it Curiel and and viral pneumonias that Curiel and so and viral as pneumonias a result the and starts so off as with a inflammation result in the the lung starts from off those with inflammation particular in the lung from those Causes particular the Causes inflammation becomes the waves inflammation waves becomes of amplify waves waves inflammation of amplify that starts to affect inflammation other organs. that starts Like to your kidneys affect and heart other organs. Like and your ultimately kidneys and patients heart with AIDS and wind ultimately up. patients They with don't AIDS survive. wind up. They die from They that don't survive. multi organ They failure die and from that that multi he's organ organs failure and that weren't he's able organs to sustain the weren't able inflammatory to sustain injury the we've inflammatory heard a lot about the respiratory injury challenges we've heard that a lot can about occur the respiratory to people challenges infected that can occur with the to covid people nineteen infected virus with the are covid nineteen the ones virus who end up on are respirators the ones suffering who end up from on respirators arts and suffering what from role arts does arts and play in what the role mortality does arts of play patients in with the mortality Covid nineteen of patients with Covid arches nineteen probably the primary arches probably cause the primary of death in most cause of the cove in of nineteen death patients. in most of At the least cove in nineteen that's what patients. the the At least reports from that's China what the and the elsewhere reports suggesting from China and elsewhere suggesting Covid NINETEEN INDUCE. Cards Covid NINETEEN INDUCE. has a Cards lot of similarities to has a garden lot variety of similarities area to garden variety but it area also has some unique but it also changes has some that unique changes that may that not be typical. Air that may not S. as be well typical. Air and S. as well The ventilator and The ventilator Think this is an important Think this part is an important of the story. part of the That story. patients with That patients With Kobe with nineteen viral With infection Kobe nineteen or viral other causes infection of or other causes Respiratory of distress like I mentioned Respiratory substance or distress bacterial like I pneumonia mentioned substance trauma or bacterial and pneumonia you have trauma Increasing respiratory and you have distress Increasing respiratory your lungs. Start distress to fill with Lewis your lungs. Start to and fill with Lewis the work of breathing and when your the work lungs are. of breathing Our when full of your fluid lungs is are. very very Our full of fluid rate. is very very So these patients rate. generally run So out of these patients generally Energy run out of the fatigue Energy and they need then the fatigue later to help and they need then with later their respiration to help with and their so respiration the the and the so the the the irony the of of the this is that irony the ventilator of of while saving this your is life that the ventilator while because saving your your life new patients for an out because of your energy new patients agreed on for an their out own of energy agreed then on later their own also the major then later cause also for information the major as well. cause for information That's been as known well. for now sometime That's and been known for so now strategies sometime to and address so strategies a yes to whether it's address cove nineteen a yes induced whether or it's otherwise cove nineteen induced need or to take otherwise into account the fact that then need later to take contributes into account to that the fact inflammatory that then later burden contributes patients to that with they inflammatory burden patients with they as an academic. You've done functional as an academic. You've done functional genomics work that identified candidate genes that contribute to inflammatory disorders. Such as arts this led to a focus on the NAP. Jean what is Napkin? And what role does it play in the inflammatory cascade? Yes well that's That's exactly right. Dan we Early on when I was a cheap home area at Johns Hopkins the New Year early. Two thousands we are group there. through clinical trials that was published in the New England Journal in this clinical. We identified the fact that the later contributed some mortality in they already s and and the hypothesis was that the way that Ben later contributes mortality. It was it was causing excessive increases in inflammation so at that point my laboratory My Research Laboratory at Hopkins we We've again focusing very Aggressively on trying to identify genes. That might be involved in. How the ventilator induced that inflammation and This is how we found that gene. That's called NAM. Nam stands for nicotinamide Fossil Rizal Transfer. A is a protein that has a normal function inside the cell. But when it's secreted from the cell floats in the bloodstream. It is a very potent planetary mediator. And the reason we think NANCE's A pretty novel target for then later induced lung injury and they are s in general including cove in nineteen induced area. Is that this. Gene is induced very early. It's one of the first genes induce patient or a animals exposed to Mechanical Ventilation is this unique to the lungs or is this across inflammatory
"nicotinamide" Discussed on FoundMyFitness
"Flash P R E M I U am premium. Really folks. This is so much better than at and it affords me the opportunity to continue making foundmyfitness fitness into the best mostly free resource that it can be without further ado onto the podcast today. I'm going to talk about a molecule that has become in recent eight years extremely relevant to the field of aging specifically. I'm referring to any D. plus which I will refer to. As N de for short and some of the related precursor molecules kills Nicotinamide riboside often referred to as an R. and nicotinamide mononucleosis tired often referred to as an these two precursor sir molecules are called an boosters which can both be found as consumer available supplements. Just in case. You've never heard of any. It's probably one of the most important molecules accuweather on the planet so important in fact that without it life would cease to exist to NATO boosters nicotinamide said nicotinamide mono nuclear tied at very high doses. This is an animal. Studies have both been shown to improve the way multiple tissues and cell types age including skeletal and heart muscle brain and stem cells. There have also I've been to preliminary clinical trials in humans showing nicotinamide riboside may raise energy levels in white blood cells. which is pretty darn cool however I still? I think there are many open questions that need to be answered regarding. Ad Boosters and I will touch on some of these concerns in this episode but the possibility that intracellular NASD may be increased from a supplement or several types of supplements is awfully interesting if not downright exciting for one. Simple reason energy levels decrease with age and a decrease in energy eighty levels across a variety of types of tissues is associated with many and naming many hallmarks of aging these hallmarks of aging that are associated with age related plated changes in the pool either directly or indirectly include things. Like loss of Proto. Stasis Might conroe Dysfunction Glucose Intolerance Insulin Insulin Resistance Cellular senescence altered epigenetics and more this is partly because the availability of promotes. DNA repair capacity while its decline is associated associated with the accumulation of DNA damaging reactive oxygen species another reason is because Nada's required for energy production so when energy levels decline as they do with age this results in less energy production in many tissues like the brain immune cells muscle etc.. That means those organs do not work as well as they once insted. During youth. When energy levels were maintained? Any ideas also required for the activation of a very important family of enzymes involved in longevity called Sir Tunes and the complete answer to why energy levels fall with age is still an open question. But there's a few things we do know. As we age chronic inflammation and immune activation two processes that consume NASD tend to go up and with them our need for DNA repair placing an immense demand on our energy pool. Meanwhile while our ability to produce and recycle tends to fall with age we're GONNA cover a lot of ground in this episode but I wanNA start with an overview of any D- Any any deal has a very important role in energy metabolism and can be synthesized in the body from a variety of dietary sources including the amino acid trip to fan which which is in tons of healthy foods like salmon spinach and nuts and the three forms of niacin which is vitamin B.. Three also found in foods like lean meats legumes veggies edges these three forms of vitamin B.. Three include nicotinamide also called Niacin nicotinic acid and nicotinamide riboside they are commonly referred to as Nice in equivalents but dietary sources of energy are not the major source of any D. The major source of energy is through a recycling mechanism that we will discuss later. The reason for that is because our organs require such large quantities of that it would be impossible to consume enough from our diet. So why why do we require such large quantities of any first and foremost energy plays a critical role in energy metabolism critical. Meaning without it. You can't make energy entity participates in back and forth processes of reduction and oxidation often referred to as Reebok's reactions these alternating conversions of NFC's oxidized form which Canady to its reduced form. An Age are crucial for the metabolism of glucose and fatty acids and the formation of ATP. Since both the oxidized is in reduced forms of amd are essential for these linked sets of reactions cells need to maintain massive concentrations of both and a D. and an age basically without these molecules. Not only would we cease to exist but life on our planet would cease to exist and it is also a cofactor for many different important enzymes in this context a cofactor means something that is required for an enzyme to work at has to bind to the enzyme and this activates the enzyme so it can performance function so. Let's talk about a few of these enzymes. Several these NATO required enzymes are inside the Mitochondria and this is another way and participates in the generation of energy aside from itself being a type of energetic currency it also acts as a cofactor for enzymes involved in the production of energy from glucose outside of the minor Qendra this is referred or to as glycolysis many types of cells us look like Hollis's as their primary source of energy. For example. Red Blood cells do not have any medical Andrea so one hundred percent of the energy. They require to perform their function of delivering oxygen and other goodies to other tissues in the body comes from glycolysis and plays a very important role in mitigating DNA. A damage you need repair damage to DNA. That is because any cofactor for one of the most important enzymes involved. In repairing DNA damage called part one the activation of part one requires an enormous amount of any D for example excessive DNA damage in subsequent one activation have been shown to decrease energy levels to twenty to thirty percent of its normal levels. The ability to repair DNA damage is important for longevity. LYMPHOBLASTIC cell lines established from blood samples of humans who were centenarians. One hundred years or older have significantly higher part one activity than cell lines established from younger individuals. That are seventy years old part. One activity has also been correlated with maximum lifespan. In mammals the higher the part one activity the longer lifespan. For example the activity of part one one was measured across multiple Mammalian species and the difference in powerpoint activity between the longest lived mammals tested which were humans and the shortest lived mammals tested. which were rats? It's was fivefold so not too much of a surprise but genomic stability which relies on energy in general and pop ones specifically maybe very important morton longevity is required to activate signaling proteins knowns or two which are highly conserved enzymes play roles in health span and longevity in multiple organisms uh-huh so to ends are linked to the regulation of variety of metabolic processes like the response to stress and the modulation of lifespan. The way they do this is through EPA genetic regulation so twins utilize ad to remove specific chemical structures called seal groups..
NAD+, Nicotinamide Riboside, and Nicotinamide Mononucleotide with Rhonda Patrick
"I'm going to talk about a molecule that has become in recent eight years extremely relevant to the field of aging specifically. I'm referring to any D. plus which I will refer to. As N de for short and some of the related precursor molecules kills Nicotinamide riboside often referred to as an R. and nicotinamide mononucleosis tired often referred to as an these two precursor sir molecules are called an boosters which can both be found as consumer available supplements. Just in case. You've never heard of any. It's probably one of the most important molecules accuweather on the planet so important in fact that without it life would cease to exist to NATO boosters nicotinamide said nicotinamide mono nuclear tied at very high doses. This is an animal. Studies have both been shown to improve the way multiple tissues and cell types age including skeletal and heart muscle brain and stem cells. There have also I've been to preliminary clinical trials in humans showing nicotinamide riboside may raise energy levels in white blood cells. which is pretty darn cool however I still? I think there are many open questions that need to be answered regarding. Ad Boosters and I will touch on some of these concerns in this episode but the possibility that intracellular NASD may be increased from a supplement or several types of supplements is awfully interesting if not downright exciting for one. Simple reason energy levels decrease with age and a decrease in energy eighty levels across a variety of types of tissues is associated with many and naming many hallmarks of aging these hallmarks of aging that are associated with age related plated changes in the pool either directly or indirectly include things. Like loss of Proto. Stasis Might conroe Dysfunction Glucose Intolerance Insulin Insulin Resistance Cellular senescence altered epigenetics and more this is partly because the availability of promotes. DNA repair capacity while its decline is associated associated with the accumulation of DNA damaging reactive oxygen species another reason is because Nada's required for energy production so when energy levels decline as they do with age this results in less energy production in many tissues like the brain immune cells muscle etc.. That means those organs do not work as well as they once insted. During youth. When energy levels were maintained? Any ideas also required for the activation of a very important family of enzymes involved in longevity called Sir Tunes and the complete answer to why energy levels fall with age is still an open question. But there's a few things we do know. As we age chronic inflammation and immune activation two processes that consume NASD tend to go up and with them our need for DNA repair placing an immense demand on our energy pool. Meanwhile while our ability to produce and recycle tends to fall with age we're GONNA cover a lot of ground in this episode but I wanNA start with an overview of any D- Any any deal has a very important role in energy metabolism and can be synthesized in the body from a variety of dietary sources including the amino acid trip to fan which which is in tons of healthy foods like salmon spinach and nuts and the three forms of niacin which is vitamin B.. Three also found in foods like lean meats legumes veggies edges these three forms of vitamin B.. Three include nicotinamide also called Niacin nicotinic acid and nicotinamide riboside they are commonly referred to as Nice in equivalents but dietary sources of energy are not the major source of any D. The major source of energy is through a recycling mechanism that we will discuss later. The reason for that is because our organs require such large quantities of that it would be impossible to consume enough from our diet. So why why do we require such large quantities of any first and foremost energy plays a critical role in energy metabolism critical. Meaning without it. You can't make energy entity participates in back and forth processes of reduction and oxidation often referred to as Reebok's reactions these alternating conversions of NFC's oxidized form which Canady to its reduced form. An Age are crucial for the metabolism of glucose and fatty acids and the formation of ATP. Since both the oxidized is in reduced forms of amd are essential for these linked sets of reactions cells need to maintain massive concentrations of both and a D. and an age basically without these molecules. Not only would we cease to exist but life on our planet would cease to exist and it is also a cofactor for many different important enzymes in this context a cofactor means something that is required for an enzyme to work at has to bind to the enzyme and this activates the enzyme so it can performance function so. Let's talk about a few of these enzymes. Several these NATO required enzymes are inside the Mitochondria and this is another way and participates in the generation of energy aside from itself being a type of energetic currency it also acts as a cofactor for enzymes involved in the production of energy from glucose outside of the minor Qendra this is referred or to as glycolysis many types of cells us look like Hollis's as their primary source of energy. For example. Red Blood cells do not have any medical Andrea so one hundred percent of the energy. They require to perform their function of delivering oxygen and other goodies to other tissues in the body comes from glycolysis and plays a very important role in mitigating DNA. A damage you need repair damage to DNA. That is because any cofactor for one of the most important enzymes involved. In repairing DNA damage called part one the activation of part one requires an enormous amount of any D for example excessive DNA damage in subsequent one activation have been shown to decrease energy levels to twenty to thirty percent of its normal levels. The ability to repair DNA damage is important for longevity. LYMPHOBLASTIC cell lines established from blood samples of humans who were centenarians. One hundred years or older have significantly higher part one activity than cell lines established from younger individuals. That are seventy years old part. One activity has also been correlated with maximum lifespan. In mammals the higher the part one activity the longer lifespan. For example the activity of part one one was measured across multiple Mammalian species and the difference in powerpoint activity between the longest lived mammals tested which were humans and the shortest lived mammals tested. which were rats? It's was fivefold so not too much of a surprise but genomic stability which relies on energy in general and pop ones specifically maybe very important morton longevity is required to activate signaling proteins knowns or two which are highly conserved enzymes play roles in health span and longevity in multiple organisms uh-huh so to ends are linked to the regulation of variety of metabolic processes like the response to stress and the modulation of lifespan. The way they do this is through EPA genetic regulation so twins utilize ad to remove specific chemical structures called seal groups.
"nicotinamide" Discussed on FoundMyFitness
"Just different EPA genomes and Jessica Catala works on the epigenetics of east cells and try to work out exactly what I was describing earlier about the distribution of proteins between Dina breaks and controlling thing a cells age. And so though that's it that's basically the world's elite teams of epigenetics of aging but it's exploiting Two three years from now we'll have hundreds of lives. Yeah sounds I mean this is cool. It's something I've definitely this. This whole idea like is definitely in in some way. Come to my mind with the the Yamanaka factor and using that to like a reset for aging. Not just about making. I mean there's always the the okay well you can keep replenishing your your cell types types in different organs and kind of keep it going but like to like turn it back to think. It's a young cell. There's gotta be a way to be away right. Yemen did us a big favor. Actually John Gordon who won the Nobel Prize with Yamanaka. He really told US years ago. Back in the nineteen eighties that that reversal of aging is possible. And we didn't really get it. What he did was he took an adult cell nucleus from Tadpole put it into a frog's egg and made a new type whole what that actually tells you is that your genome can be reset to go way back? Aging is not a one way street. Yeah the fact so you can take your adult song. Reset to stem. Cells is proof right and we and now we know the machinery at least the beginnings of it and it's very exciting time so excited right now like. Yeah there's all this other stuff we were going to talk about. You know we you mentioned boosters and we probably should should definitely get into that but well this central to because as I mentioned the proteins many of them are moving around controlling the EPA genome. You want to stabilize that is best you can animals like whales and naked mole. Rats have a very stable able EPA genome so this moving around routines and EPA. Genomic noise accumulating if we're exercising we're taking ad boosters we do slow that process down. I believe believe. Let's talk about. What boosters are so the precursors for the issue making eighty in our bodies and we? Yeah we do. And so eight is recycled in the body. Because there's grams of Econ eight that much easily. And there's a psychological the salvage pathway van de and it all starts with nicotinamide which is a a form of vitamin B. Three. But you can't just or you can but it's not very effective just overdose on vitamin B.. Three because you need other things to make the big molecule. NADC is the reasons called nicotinamide. Adnan dynamically tide. Is that Scott. These three main components and the dynamically tide is related to DNA online right. But that's beside the point. It's a big molecule. So that if you give a big molecule to sells it doesn't get taken up so we don't feed animals in D. and we don't just feed them nicotinamide which is the little end pot of eighty. 'cause it's too small in the UK these other parts so any man and in our two molecules it stands for Nicotinamide Mono nuclear tied which is essentially the precursor the immediate precursor to eighty eighty. If you give a cell in it will be taken up by transporter which was just discovered by my buddies keenum I used to work at. Mit Now he's at washy. Few weeks ago He wrote about it. I wrote about it that There's a transporter that sucks up intimate and the man is converted within one step to eighty in the cell. And now it's locked big big. Marcus locked inside. The cell and that step is carried out by an enzyme. It's got a name called an empty and that ends on goes up distress and calorie restriction in yeast. It's the same step. And so we show years ago that that step of conversion of an amendment and a D. or in yeast What is it Nicotinic? Acid into an eighty is critical. Step for boosting. Ad When you're going through your circadian rhythms when you exercise when your cells stressed and without Out that step you. Don't get the benefits cal restriction your organs. Start to get old. So what is in our so in ours Fairly popular a lot of people have heard of it sands nicotinamide nicotinamide Rabo side. And all it is. It's just a smaller version of anime in without a phosphate on there so there's phosphorous on it. I'm so if you've taken are your body has to I put on a false first and then it has to Basically linked to them together to make the do so with all that said and our gets converted into animation first and then into NATO. Yes yes it has to yeah But in our and and and have both been shown to raise the levels in animals and in humans as well and small nuances about the differences but they both seem to be effective Not just in humans. Actually I should say in mice orbiting yeast. They work as well which is nice I suppose people are interested in the plant world. And what we eat the same pathways. These tune pathways exist in plants as well and they get turned on In response to stress we call this Zeno Hamas the idea that when we eat stress plants we get those molecules. They help help bodies so resveratrol back to that old chestnut. It's a great molecule that is produced when the grapes get stressed and fungus a the fungus will stimulate it or like of water so the when they've harvest red wine they don't they hope for a dry season that will boost the virtual levels and although although good good polyphenol molecules and we think that I think that When you ingest those molecules the tunes are have evolved to sense the plant world and if your food is stressed out your body will hunker down and become fitter as a result of sensing that because we can see crops that are dying or if the water tables drying growing up? Maybe contestants that little animals that we evolved from or even you know Squirrel. It's too dumb to know that it's food. Supplies stressed out. Its body has to take care of that that message. Yes so the spirituals. Activating all these stress response. Pathways that are basically you know in our you know we have in our inner body the and and basically turning on all these genes that are helping them deal with stress. But they're like staying activated for longer and so when you know basically aging which is a stress You're if you're basically dealing with aging better right couldn't put them myself and then the opposite if you spend your whole day sitting or typing or You're always satisfying in your hunger your tunes and your other pathways and economies tour. They say hey times are good. Let's just grow tissue goforth. Multiply Oy and not build sustainable body in the long run and because there's always a trade-off which which Tom Kirkwood call dot the disposable Saima hypothesis houses. And it's very true. You always have your body in a state of a little bit of stress hormone. We call that. Yes people listening to the PODCASTS. Or heard me talk about armies quite a bit my favorite is sulfurophane that molecule and the cruciferous vegetables. But I've been there is virtual field when I I was following it back in early. Two thousands You know is a very skeptical that there would be any affecting humans taking reservatrol very trial because certainly not from drinking glass of wine but From supplementing just because it seemed as though like the doses required to get some really beneficial effects. It's at least in some of the rodent studies seem sort of you know high and it wasn't didn't seem very attainable. But as you know this there was a really really Sort of compelling primate study in Rhesus Rhesus monkeys forgot that was published she was like made to thousands or doesn't doesn't eleven or something refer to cubs group at NIH. Yes that's right They they gave these rhesus monkeys Repair trial and I think they start. Start out with the lower dose like eighty milligrams per kilogram went up to like four hundred and eight any reason. Do you know why they start with. I've seen more than one study to that. Yeah so just anecdotally. What roughly told me I think is that They started at the low dose and didn't see a change in pulse. Wave Velocity in the blood vessels. So they up to. And then that's what I sorta benefit. Oh Okay so well this study was you know the the doses were very doable in humans when you convert And and basically they you know feeding these these monkeys feeding Mike this terrible high high gross diet high sucrose on high fat and they like the cause them to have like forty percent increased. Eric Orrick stiffness but the spiritual completely ameliorated so I was like holy crap. That's pretty cool. I think that was the one one study. That sort of changed my view And then I started sort of get into the literature and read morons there has been a variety of clinical studies. Is You know and yeah well well. I'm glad somebody's reading the literature because there was there was a hate me club with resveratrol Because it got so much attention at anything that gets a lot of attention gets the hate me club back in reverse but virtual I still take virtual Probably a Graham also every man really. Yeah in my yogurt. I don't measure it out I just just shake it in so it might be half a gram to grants from your own late stash. It's like us in the basement. it is I'm not they don't really find doses of resveratrol above two hundred fifty milligram. Yes right you made a good point. which is it's it's a really Insoluble molecule and. That's one of the well the two problems with virtual. What is it really insoluble? So if you give it as a dry powder to an animal or humanists less likely to get absorbed we know that as a fact included with a bit of fat it'll go up five to ten fold in the bloodstream. Really big effect. We've seen in mice and monkeys with bit fat in the Diet as well. I'm in the second problem with virtual is that it's light sensitive. And so those people who researches who put it in a plate with worms terms or Didn't treat molecule with respect. He Goes Brown. It goes off. It's one of the reasons. It's very hard to put in a cosmetic because medical turn brown if you use Brownnoser virtual at work you've got to keep it in the dock in the cold and it'll be fine okay so so Debasement cold dark mark and also. I think there's various forms Trans resveratrol. I go for trends because when we gave this form to this or to an enzyme it didn't activate it but the Trans worked brilliantly. Yeah roughly Kaba actually He's been a good friend. Over the years colleague he did the study with else on the mouse. Whereas virtual study that showed that on a high-fat diet those mice for extremely healthy and long lived and their organs? When they opened up the mice there were pristine? The mice was still obese. Because we didn't give him a lot of virtual is pretty low dose but their organs were so beautiful Their arteries when you stain them for oil fat it was night and day. The ones on reservatrol will the ones without reversal staying with fatty lumps reversal. Clean Clean and that alone makes me say you know revert. trolls probably not GonNa hurt me and It may very well help cut. INVESCO system seems to be really important for cardiovascular the vascular system like and I'm just kind of want to know why why is it we we have a number of ideas and virtual is a dirty molecule. So there's not just one way it works works So to definitely involved we now have announced that's mutant for the rest virtual activation of one. So we now see that some some aspects like endurance convertibles seemed to be through certain so one of the effects is through sort was anti inflammatory actions in the lining of of the blood vessels. The into the'll cells. How yeah that seems to be important?.
"nicotinamide" Discussed on FoundMyFitness
"Yamanaka factors a group of four transcription factors that can reprogram and adult cell to become a pluripotent stem cell. That can form any cell type. How short term treatment with Yamanaka factors can reverse cellular and physiological homer hallmarks of aging and prolong lifespan in mice with a premature aging phenotype phenotype how fasting exercise and other lifestyle factors may slow the rate of EPA genetic aging but may not be sufficient to reverse it like some of the powerful Yamanaka factors may be able to do? We also discussed Dr Sinclair's hope that we may eventually find a way to induce Yamanaka factors in a way that is more safe applicable. Oh to humans than current genetic engineering in viral techniques use. An animal research can do and so much more a few things. I want to mention before we ought to this amazing podcast. In addition to this episode I have put together a bonus episode that sort of focuses on my personal concluding take on everything. NASD nicotinamide right beside and nicotinamide. Monica tied that episode comes out to the wider world sometime next week and should be of great interest to anyone that enjoys this conversation today. Having said that if you are a premium member you can get a pre release of that episode right now. That's right right now. By grabbing the brand new members only podcast feed the members. Only podcast feed. What's that you may ask? This is a cool new way to get occasional early access to upcoming episodes some exclusive zip content like my members only QNA's and more that's not the only benefit premium members get either along with already great notes released for free with every episode for members. were now including a convenient powerpoint where you can quickly skim. All the graphical figures steady quotes and more usually reserved for the video only just by way of example. The presentation for this episode comes with over one hundred fifty slides. That usually you'd have to watch the entire video to see which seems mighty redundant if you've already listened to this episode all the way through this new suite of real concrete benefits reserved for premium. Members is my special way to give back to the people that automatically enabled me to build my fitness into the amazing largely free resource for the wide world that it is learn about all of these brand new benefits more than even make sense to go into right now as well as the back story and motivation or even get signed up for a dollar per month by heading over to foundmyfitness dot com forward slash premium. That's found my fitness dot com forward slash P R E M I U M premium..
"nicotinamide" Discussed on The Rich Roll Podcast
"For honeybee populations field trials just concluded last year. We made our announcement the end of last year and. We Pat be patented this, but then opened up royalty free. The patent honeybee farmers around the world. And then we hope at some point this real year to roll out bio patties and bio sprays that are based off these species after our UC Davis trial commences. And so this is a field, a large scale, field, trial and almond farms, which is kicking off in a couple of nights. So essentially, it's a probiotic, Patty, it's almost like a pancake. Okay. So in the hive, and, and that populates, their gut flora, with something that helps them avoid the negative impacts of these nicotinamide of pesticides annoyed of the foul brood disease to three leading causes of colony club. Right. And just for people that don't know like paint the picture of colony collapse disorder at its at its, you know, alternate. Yeah. Beezer the most efficient pollinators that have or ever will be discovered or invented if we lose bee populations we lose nearly every single blooming crop or fruiting crop that you find maybe some in small quantities root vegetables would persist, but a lot of the diversity that you see from above ground pollination. Is are virtually gone. I mean, models that predict it say that the supermarket the, the fruits and vegetables of the supermarket be decreased by over ninety percent. If. Yeah. I mean, the easiest way to say it is whatever you ate for breakfast this morning. Probably won't be here. And that's an and there's also other implications like cotton, for example, that have of course implications for other industries and other uses it really broadens, the opera on the work that you're doing. This is not just hey, you know, like we want to create a probiotic to make people healthy like it's really an effort to address the declining vile diversity of the planet at large, and the implications or the, the sort of applications of this science at your developing are really limitless. And I think also the applications of science that's really often stays kind of guarded behind, you know, in academic institutions, or for many reasons, often doesn't make its way to humans or or for other applications that can be immediately kind of put too. Heusen to make an impact. So that's part of the bridge. We've built and very proud of. One of the things that, that really blows my mind about the microbiome in the human body. Is this developing science and awareness around the connection between the gut and the brain and my first introduction to this was through these? Studies that were done on cravings, and essentially in my most Lehman ability to describe this, what I took from that was that your micro bio, can literally essentially hijacked, your nervous system and signal your brain to crave certain foods that feed. The, you know, whatever it is that, that flora, actually needs to feed on is that accurate. Can we talk about like that, because that's crazy? We think of ourselves, essentially human beings. We're making decisions where we have self well, and all this thing we have free will. And yet, the idea that, you know, these micro organisms that live within our body are actually dictating what we crave. And what we ended up putting in our mouth is kind of a mind blower. Well, I am I exaggerating hair or no. So high fat consumption, increases the prevalence of organisms, that are life Ilic just low fat loving. And it's annoying. Canary most of the organisms that evolved for. Generations in humans are carbohydrate loving, or fiber complex, carbohydrate loving organisms, and so the community does change. It's unclear whether the microbes are driving dot.
"nicotinamide" Discussed on The Peter Attia Drive
"It's not even needs to its Ken, right 'cause NASD to my knowledge does not go from plasma into cell. But it's hard. It. Does it does? It just might be that you don't have enough in the plasma to justify the will. You do if you're injecting it also this is interesting. Okay. I wanna come back. I'm gonna park that because I want to finish. But I'm gonna come back to that. So nicotinamide is the is the physiological circulating form of niacin that all cells will use to make nicotinamide. I mean, excuse me that all cells won't use to make adeem. Minor exceptions are about. Five weekend. Make some nice in from trip to Finn. And about ninety five percent of that happens the liver in the liver. Five percent happens in the kidney. So there is some some tiny bit of this that the kidney is making its own. But overwhelmingly. With that tiny exception. Tissues getting any because it took nicotinamide of the blood that the liver made from its store of energy. Now, let me expose my ignorance in biochemistry. My forgetfulness nicotinamide is charged or not, I know any ideas, but known content might not charged. Okay. Nicotinamide makes its way into a cell through a active or passive transporter, active transport believe I would need to check that. That's okay. We'll we'll figure all that out. Once nicotinamide is in the cell. How does it combine with Adele at cetera to become energy? It goes through two steps that are ATP dependent. It gets converted to nicotinamide on a nuclear tied. And then it gets converted into any d a portion of the Nick of the Enin nicotinamide on nuclear portion of that becomes an are. And then gets comes back to an and I don't know exactly why. But I think it's like a pressure release valve. So if you're trying to hold onto the nicotinamide and get it to any de more than the. A- at which you can make the NASD you might convert some to end up our to kind of hold onto it got. And then it comes back in and and our to not NRT tuner. So you have nicotinamide you up to an immense you go up to any you can go from over to NR, but you have to go back over from art to amend to get an eighty. Yup. And I think of it as a cycle ways to look at this picture the picture that I have in my mind is NASD going to N A M to NNSA's a cycle with an are being a pop off of an okay? Yes. So what you're talking about is in the case of any consuming. Enzymes like, sir twins in parts that are using any deferred for DNA repair. And all the things we were talking about before what they do when they consume the NASD is they release nicotinamide. So imagine you're a muscle cell. You took originally to get every molecule of any do you have originally took some nicotinamide from the blood. But then you did things with it. Some of those things were what you were talking about with oxidative phosphorylation, you don't consume any in that process. You just cycle it back and forth use it over and over northern over again. But some of the things that you did were at the search wins in parts that are engaging in protection and those enzymes will consume the NASD to generate nicotinamide. The big problem here is that nicotinamide is an inhibitor of all those enzymes through negative feedback loop. So you have to have to have to have to have to do something with the nicotinamide very fast. Were you need to methylated bring it back to the earlier discussion and pee it out. So nicotinamide is circulating as the circulating form in the blood with intracellular. You don't let it hang out there. You do something with it. Right. So you take in the nicotinamide, and you either make any were you get rid of it yet? Actually, I didn't even realize one could have free nicotinamide inside a cell, which I guess you're basically saying but Bonin momentarily momentarily, but it doesn't hang out there in that flow doesn't. Okay. So now, let's go back to the question that I'm still trying to wrap my mind around which is if I give you a gram of nicotinamide riboside, you're saying none of that NRA is basically gonna leave the liver instead just nicotinamide as leaving the liver. It is found in the blood..
"nicotinamide" Discussed on WDRC
"Talk is our number and during this program we're going to share some really exciting information about a nutrient that i've been focusing a lot on in the past couple of years it's nicotinamide riboside and according to new study some very very exciting results in a challenging neurological condition eight seven seven seven two six eight two five five we'll also talk about the downsides of tonsilectomy an opera an operation which i regret to have undergone i didn't have a lot of say in it because i was a kid but we may be doing our kids a disservice might take out their tonsils and before we get your phone calls let's talk about exercise that's going to be a theme during this program why do i exercise well some mornings i you know it's kind of hard to get out of bed and whatever regimen i haven't store for myself whether it be running biking swimming strength training yoga sometimes it just not feeling that push myself to do it because the benefits are enormous and this morning it was perfect weather here in new york not too hot we've been experiencing a merciful reprieve from the hot muggy weather of summer and perfect conditions for a nice run i hate it out.
"nicotinamide" Discussed on WINT 1330 AM
"To the right prefrontal cortex that's good because it's the area of the brain devoted to higher cognitive functions so good stuff p q q reverses cell damage it reduces the presence of chemical stressors in the brain and can i think really form an important part of a regimen designed to slow the progression of neuro degenerative diseases like alzheimer's and parkinson's and so here's really what i'm very excited about talking to you about nicotinamide arrive aside for a long time as a sort of companion nutrient to coenzyme q ten for mighty conrail support of course we talk about the n t factor reminded conrail support that's important too but really scientifically valid way of supporting mighty qendra function particularly the brain is through use of nicotinamide rival side and here's the news study hope for parkinson's patients aside is discovered taking vitamin b three that's the regular vitamin b three there would be nicotinamide or nice or sin we don't want to do that you'll just get flushing but nicotinamide riva's side is a special form of vitamin b three that can stop nerve cells from dying off in what could be a starting point for treatment they say that nicotinamide ride a could also help store function and nerve cells with parkinson's this was done in a in a fruit fly model of parkinson's.
"nicotinamide" Discussed on Quirks and Quarks
"Isn't and they caused harm long after application these things begin to disappear will take me through the scientific studies that have shown the relationship between neo knicks and be declines so at this point there there's something like one thousand five hundred different studies that have been conducted and reviewed and this is the evidently basis for the position that the scientific community is taking on this to basically say that every single new nicotinamide pesticide is demonstrated to harm be populations in one way or another when i say be populations i don't just mean honeybees i mean also bumblebees and other kinds of wild bees that are critical for pollination like mason bees which are very common in canada and europe so we've seen experimental evidence that was very carefully conducted in canada and europe great big field trials sometimes even funded by the chemical industry that demonstrate that bees reproductive capacity begins to disappear when neo knicks are applied and honey bee populations begin to fade away worker life expectancies begin to drop very sharply and when you put all of this evidence together the case i'm afraid has become quite clear that neo knicks are very harmful to insects that really benefit agriculture what's at stake if the continuing use of these pesticides kills off the bees i think it's very important for us to remember that about one out of every three bites of food that we consume is a consequence of the activities of pollinating species like bs there are something like eight hundred b species in canada losing these bee populations either.
"nicotinamide" Discussed on Bulletproof Radio
"And we can basically put it in a machine and we can determine the levels of all of the energy metabolites with these two technologies can basically tell us whether any ideas involved in any process that you want like you know chronic fatigue syndrome someone asked me about that recently and he said you think eddie might be dysregulates and in chronic fatigue syndrome and i said well i don't know what i know i can figure out how we can tell which is you know just get some tissue and if we see the genes are dysregulates at the metabolites are disrupted is telling us that any the is miss regulated the most amazing thing one of the most amazing things that we did in the last year religious this heart failure story that i was telling you about where this mouse is on its way to getting heart failure it's it's even presymptomatic and it's any d starts dropping and it's any dropping and it's nicotinamide riva's side kindness to gene is spiking up so the the gene pathway to convert an are into any going up while the nasd is going down and turns out what turns that on is something called amp chinese so it's this low energy sensor and the low energy sensor is turning on this end our pathway so that if you're if you're the lucky mouse who is supplementing with nicotinamide rival side you have a much better heart function because at ours available to those stress cardiac cells that are having the spy winter jeddah crisis so to some degree people will have a a more noticeable performance issue after they're they're all already you know somewhat debilitated but there's a protective aspect i think of having an are available when stuff.
"nicotinamide" Discussed on Bulletproof Radio
"Oh sweet the the boettcher sweetener we have is it's derives based thing but your body doesn't combine nice into and right bose very effectively to make nicotinamide rival which doesn't do that yeah there's actually no example in all of biology in which a base like nicotinamide or adding is just combined with ribe owes to form a nucleoside at sort of not the way it works is so nicotinamide can be can react with a compound called prp to form an amend and then an amend can go to any d or nicotinamide rivasi's can be phosphor elated as technical term to an amend and then form an but the the rivals and the nicotine the nicotine mites great high dose nicotinamide doesn't really do what you want to do because high dose nicotinamide will inhibit 'this enzyme ser two inns whereas highdose nicotine dr aside is in any precursor that doesn't inhibit the cirta wins nicotinic acid is great especially for lowering ldl cholesterol lowering the back less all in raising hdl cholesterol but as to limitations one is that doesn't you know regenerate and a d in all tissues for example doesn't regenerate and a d in neurons which you know we manage them out that matters most and also high dose nicotinic acid causes a flush reaction that's pretty uncomfortable so ours is basically you know it's available to all cells and tissues it doesn't it cer tunes it doesn't goes with lush reaction and that's why it's more valuable three.
"nicotinamide" Discussed on Bulletproof Radio
"Rating atp instead we're storing the fuel as lipid droplets at paddock status but a few years ago my lab did an experiment in which we essentially wanted to look at obesity and type two diabetes in in a mouse and there was a lot of speculation that that might depress liver nasd as well and it did but it more strikingly depressed liver na dp h and naacp h is the central regulator of reactive oxygen species toxic so when you generate ross the reactive oxygen species have to be detoxified in a manner that depends on adp h so when you overfeed a mouse you end up with a storm of reactive oxygen species damages molecules you know systemically including in its nerves and these mice develop pre diabetic and diabetic neuropathy on the basis of their ability and diabetes and we can prevent that with provisions of nicotinamide riva's side that's just the first two knows say if i'm going to go out and drink a lot which by the way if you guys have re read the stuff there's all info graphic on if you're going to drink how to prevent damage i mean are you saying that having higher amounts of nicotine riboside is a good idea pre or post binge and by the way you shouldn't be benching he has me but benching that's good but having higher level of of nasd and you're by the way the liver loves taking up nicotinamide drive aside and so orel and our is very highly available to the liver and so i would say that if you were like going into passover seder some other reason why we're gonna have four glasses of wine just as you know i did on friday night last week being prepared preparing your body with a little bit more and our is probably a pretty good idea this is something where i got a positive for a second their child chirp you're not allowed to say at ness.
"nicotinamide" Discussed on Bulletproof Radio
"Wins and ser to these longevity promoting genes that are found in everything from yeast to human beings folks were starting to manipulate the nasd pathway to see if they could extend the lifespan in something like a yeast cell and when i looked at the evidence basis for how an is made even something as simple as a yeast it seemed like there could be some missing steps and essentially when we knocked out the gene that i was working on we found that there was another way to make any d and that was through nicotinamide riboside so that's when we discovered an are as vitamin and the nicotinamide riva's side kinds pathway to any d back in two thousand four and so this is going back a while and this is one of those kind of unusual supplements that year outs are on the corners of the internet around longevity and given that i'm looking to live to at least one hundred eighty maybe a little bit longer or a lot longer actually i'm completely willing and able to find everything and try everything all at once to see if it works and this is definitely more things i've been aware of for a while and i've i've taken on and off over the years and i'm thinking for for people listening do you believe given that you're very well qualified understand what was going on biologically de believe that by increasing in d in our in our bodies that it we have a reasonable chance of extending our lives even a little bit let's take a step back and talk about what any actually does all your enemies and come on come on.
"nicotinamide" Discussed on WVNJ 1160 AM
"A big impact on adding a more youthful element to the health status of their major blood vessels there's another dietary supplement shows promise for reversing cardiovascular aging and it's not something that carlson makes although have asked them to but it is available in the marketplace it's called nicotinamide riboside and a supplement of nicotinamide riboside is shown to be so effective that it mimics caloric restriction to boost arterial health so that's pretty doggone interesting this is a university of colorado boulder study that was published that showed that when people consume this supplement nicotinamide riboside daily it mimics caloric restriction kickstarting the same key chemical pathways that are responsible for the health benefits of caloric restriction the supplementation improves blood pressure and arterial health particularly in people who have mild hypertension this was the first study in humans over a period of time of nicotinamide riboside there have been a number of animal studies with this supplement this is a supplement it's called nyah jen and i take it every day i have been very encouraged by the animal studies and nicotinamide riboside lev raises the levels of na d and and that is a marker of youth so what they did was this was the department of integrative physiology at colorado university at boulder they found that the supplement was well tolerated and it activated the same key biological pathways that calorie restriction does they published in the journal nature communications and they got people between the ages of fifty five and seventy nine from the boulder area and for six weeks they gave them five hundred milligrams twice a day of nicotinamide riboside and they took blood samples and physiological measurements and they found that a thousand milligrams daily of nicotinamide riboside boosted levels of a compound called nicotinamide adenosine die nuclear tied and ad it boosted nasd by sixty.
"nicotinamide" Discussed on WVNJ 1160 AM
"We just went maybe we feel a little more tired we feel a little more at the effect of the activities of living on a daily basis and we think oh it's it's just my age my ages catching up with me how many times have you heard people say that sometimes it's not that and it is willing more the impact of not being particularly wellnourished and we find ourselves spending so much time doing for others and running around in getting things done and multitasking and this is a complicated world we live in and we are called to do more and more and more with less and less quite often um so that sometimes we just catch a meal here and there now grab something on the way too chirchir schooler wherever it is that we happen to be on the way to and the adjust may not be that the diet that we're eating is the absolute diet we could possibly come up with for ourselves and if that's the case supplement make sense and if energy is your issue there certainly are some things that help and these things the coenzyme q ten is the derived those and the nicotinamide riboside they are three tools that i have come two depend on when dealing with people issues of fatigue and just feeling like they can't quite muster the energy so they're you know they're widely available the coq 10 a hundred milligrams a day is probably a great does you know that if you are taking cholesterollowering medication that is in the family of statins that coenzyme q ten depletion is one of the impacts that those medication have and that can translate to fatigue so a 100 milligrams of coq you can fifty milligrams of the nicotinamide riboside and then why boasts five milligrams in divided doses three times a day and again those little packets are easy you just pop them in your purse keep them with you and akihiko and it does make a big difference one of the conference's that i was that over.
"nicotinamide" Discussed on FoundMyFitness
"The country of the process called oxidative phosphorylation in that process is is not necessarily depending on on glucose but is dependent on the deficient mighty control function so we talked about nad dependent enzyme many of these enzyme resides in the mitochondria and we found that for example the nad supplementation that's as is being tested in a variety of aging model requires surtee three quite often medical to india think tonight riboside yes yes for for example the paper we published was focused on the agents associated our noiseinduced a loss of hearing so if you actually subject nuys or humans to very acute hearing acute noise they they have a a a dosedependent loss of hearing you can protect them ice completely from this effect by a soup lamenting with nad while with nicotinamide riboside so if you're going to a rock you want to protect yourself and this is definitely somehow the apes and writers in mice it actually had an enormous effect and we founded this effect was dependent on so teeth research between knockout nice the effect was lost do you now say the on if that was dependent thirty three in the mitochondria out of stem cells because in the or was it just any salary so now in the case of hearing lost its dependent on some really uniquely sensitive cells in the in the inner ear but generally there there's been a sort of an assumption in the field that most of the effect of nicotinamide riboside protective effect our dependence t one i think in in yes and in some cases it is in in this particular case notion use hearing lost it was pretty clearly so three so even studies that have looked at for example i think.