22 Burst results for "NASD"
"nasd" Discussed on The Adam Carolla Show
"Homes with sharp corners and shouted trauma. So you look at, you look at the paint on my old house like the interior the door. That's what sixty year old paint looks like. It's not. You think it looks like it's been aged down or it's a color reclaimed wood or the forest the folks that brought you pirates of the Caribbean got in there. The artists know that imagine ears that is just white paint that is sixty three years old that turned yellow India. Right? Yeah. Oh Max panel, you gotta find the kitchen again and show the the cupboards. Paint. Blistering, and. rostro rolling down. You gotta go up the sink was all of mildew, the place smell the paint was chipping and bubbling paint at the top of the Kevin. The stupid upper cabinets were right over the sink. There was no space for your face. What you would why interface doesn't need to be there relax take it easy on the cabinets. Okay. That's where I draw the line stay house looks in a word unsurvivable. It looks difficult like a play. Under busted? Yeah. Go the. Agreed that you wouldn't be who you are today in for this. House. I worry about not being able to raise my daughter. In that has any obstacles or airs or whatever like Yeah Okay you're right. Thank you mom for lead poisoning and an eating disorder. Appreciate it. Yeah, you look how the knives are just sort of hovering labout. That's that's dangerous. You GotTa look at the Cabinet and where where the KNOB is and you see like see rust just bleeding down the side of it. These candidates look there were eight down or some fully painter got in there and did something I don't know you tell what those knives or trigger ready. I mean just one bad. What bad five minutes is. A netflix documentary. Have the good matching thermoses though one flew in one and orange I gotta say I kind of like the aesthetic. Yeah I know. I can see it would get a little exhausting but I think there's there's quite a bit of charm in this place. Well, I gotta say to walk through. The conversation to be had, you know like how the fuck could people live. This way might be one of your conversations but could tell live in it was brutal especially when I used to watch the Brady bunch all the time and I was like I want that house. I couldn't have been good. That was the first instagram in the rollout schools. Brady Adam is a crime scene. We'll put all the pictures up at. Cross. You guys can commiserate now. Is that all grout down there between the blue and All it's. Twenty years of caulking that's been put applied with a flea. Applies. Were you the first in a Corolla. Out, of the whole Corolla lineage to get into the handyman stuff because it doesn't look like a lot was being done here now I mean, yes, I was my dad had no skills. My Step Dad had a couple of skills and my Stepdad was probably the one who kept applying the Kach over the old cock and never peeling off the first level I. It'd be like it'd be like if your house at twenty five roofs on it like at some point, you have to demo the old roof got a house you put a new roof on their. Whatever say, like I'm just going to relax take a bath in this hallway. I'm. Bad. I, don't get it. All. Right. That's I grew up kids. All. Hit True Nigerian you probably don't think about your cellular health. Well, cells are the foundation of all our health. They make us who we are one important building block of our cells NASD. It's a vital vital for sleeping breathing, eating drinking and most important all the stuff we do so bad news as we age our bodies don't make an ADA like they used to good news. There's a way to boost a day. True Nine helps counteract the effects of time on your body and promote cellular repair and helps with. Healthy aging by supporting your Celio function and metabolism as well. true Naijun caught the attention of the scientific community with its remarkable to boost N. A..
'False alarm' between T-Mobile and Verizon shows how competitive 5G battle is
"Hour always on culture now depends on a working grid not just of electricity but of telecommunications and an Internet that not only never goes down but constantly speeds up efficiency is our subconscious mantra and that may be a big reason behind the hot water. All three major wireless carriers are in Verizon at and T. and T. mobile have all been promoting their new five G. wireless services heard about that each wants you to believe that their service is the fastest the most reliable hands down the best. Here's one of Reisen ads from last year at Verizon building the most powerful five G. Experience for America. That's why the NFL. Chose Verizon because they need their massive capacity of five G. With Ultra wideband, we're streaming streaming posting fans inexperienced five. Thirteen trouble in most cases, those claims can't be proved, and so the courts have banned each of these rivals from boasting about their prowess and from implying that the others are the lightweights of the wireless world witness verizon the ad I just shared with you was set in Gillette Stadium, home of the new Patriots, the company stopped running that ad last November. But that didn't stop at and T. from challenging verizon's use of the phrase most powerful to the division, the Better Business Bureau that rules on deceptive advertising cases. Why did not call the phrase into question essentially because the carriers have hardly rolled five g. out anywhere yet so it's impossible to prove one carriers mostly non existent five G. implementation is better than others. There were also questions about whether the ad was implying that the rollout was far more widespread and available to the average consumer than it was in May. The Review Board called the national advertising. Division were in a D agreed with a t and t and told verizon to using the term verizon appealed early this month they lost the said essentially consumers have no idea what most powerful means in this context the claim could not be substantiated. One it comes to making false claims don't assume that verizon is the worst offender. nope. The Empty Braggadocio is a game played by the entire industry. Go back through years in you'll see that at and T. got trouble claiming that its current four G. Network was by virtue of being fast virtually identical to five G. It even used the phrase five G. EVOLUTION TO DESCRIBE ITS FOUR G service a consumer looking for the fastest cell service could hardly be blamed for assuming that meant, they'd be using a five G. Network. Three years later, most of US still use four g networks the told at and T. to stop using the deceptive evolution phrase. At and Later agreed, and then there's t mobile, which isn't exactly honest either in late August, the NASD toll, t mobile to stop claiming that it's five G. services more reliable than the others verizon had challenged that claim t mobile said, it will appeal that decision but the Advertising Review Board also recommended that t mobile needed to stop running ads in which science guy bill nye claim that verizon's five G. coverage was barely broader than the average bus stop bench that according to industry publication fierce wireless. With a widespread deployment of five G. still some time off in the future. Why would every major wireless carrier use such inflated claims in a Word Mindshare? They want to attract and retain you as a customer. Are you more likely to stay with your current mobile carrier? If you feel pretty sure that the company will soon offer blazing fast five g service. Well maybe it's all about perception perception of what's here today and better yet perception about a speedy powerful future. That's almost hear these kinds of empty claims have a long long history in the advertising world from Telco Tonics beauty items to baby products. Advertisers repeatedly tried to stake out the territory of a- best. And rivals almost always challenge those fluffy bordering on dishonest claims. So next time you see a company claiming to be the strongest most powerful fastest or the best ask yourself. Where's the evidence chances are? There isn't any.
New Cases of COVID-19 In World Countries
"Big news over the last twenty? Four hours has been the glimmer of hope surrounding the experimental drug rim desert which shows promise as a treatment for corona virus. And we're gonNA give this news. Its own segment immediately following this top news segment so hold on for that but I I thought it might be worth summarizing the state of things across the globe at the moment without just throwing a ton of numbers at you so in a very broad high level way things look like this. Italy Spain. Germany and France seemed to be effectively. Lowering their curves. Sweden and Canada are still near the peak of their diseases possibly plateauing but need a few more days of data there note. That Britain is sadly on track to surpass. Italy's total for the most number of deaths in Europe absolutely no new cases in both South Korea and Hong Kong over the last twenty three hours. In fact Hong Kong has had no new cases for five straight days and also south. Korea was one of the early places to peak if you'll recall recording nine hundred nine cases on February twenty-ninth alone Vietnam despite its ninety five million person. Population has still not reported a single death. And only two hundred seventy cases meanwhile Sri Lanka has reintroduced a strict twenty four hour curfew as a number of new corona virus. Cases has surged there and Japan will apparently extend its national state of emergency to June as the country is experiencing a second wave of infections in the US again. A very broad way looking at the case number graphs. The number of new cases are trending up in Massachusetts Illinois Maryland. Indiana Virginia Colorado Tennessee and North Carolina things are flats in New York California Pennsylvania Michigan Texas Washington State Rhode Island and Missouri. All of those are off of their some significantly and the states where cases are decreasing New Jersey Florida Louisiana Connecticut Georgia Ohio South Dakota and Idaho and yes this is a a sad statistic to end with the US past sixty thousand official corona virus deaths since we last spoke quoting the Washington Post. The California Police Chiefs Association has told its members that Governor Gavin newsom plans to announce Thursday that all beaches and state parks will be closed effective Friday. The anticipated move follows a weekend in which thousands of people took advantage of warm weather and crowded California beaches in violation of social distancing restrictions in place in the state prompting newsom to warn of the potential of a second wave of the corona virus outbreak and quotes. Dr Anthony Fao. She told CNN last night that the long awaited day where capacity for testing in the US should reach the point where anyone who wants to test can get one is about a month away specifically his quote was hopefully we should see that as we get towards the end of May the beginning of June and quotes and the number of nursing homes reporting cases of covert nineteen in the US has doubled in the past week with more than one in six elder care facilities in the US now acknowledging infections among residents or staff in five states Maryland Massachusetts Connecticut Georgia and New Jersey. The viruses struck majority of nursing. Homes and in New Jersey infections have been reported at eighty percents of the state's nursing homes. Finally this is quoting the New York Times. The british-based pharmaceutical giant AstraZeneca said on Thursday that it had reached an agreement to make and distribute a leading potential corona virus vaccine. The drug developed by scientists at Oxford is now in human trials. The Oxford researchers are at the forefront of the race for vaccine because they had already demonstrated the safety of similar potential innoculations for other viruses that is enabled them to schedule. Human trials of their vaccine that will involve six thousand people by the end of next month. If those succeed the scientists hope to the first few million doses to frontline healthcare workers as early as September the deal with Astrazeneca could help ensure that a potential vaccine is available in the United States and around the world and quote a government run study of Gilead Sciences rim. Devere showed that the drug is effective at treating cove in nineteen the National Institutes of Health announced in a statement. Gilead said that the study had reached its primary endpoint meaning that patients on room desert recovered more quickly than those taking a placebo. Dr Anthony Fauci head of the National Institute of Allergy and Infectious Diseases or Niaid told reporters that the data from the trial showed a quote clear cut positive effect in diminishing time to recover and added that this will be the standard of care. We've talked about Rendez. Aveer A lot. In recent shows early data from a trial in Chicago indicated that patients were doing better than expected on the drug than those hopes were somewhat when a study in China indicated that patients taking room does Aveer. Didn't do any better than those in a control group in this in. Isd Study Severe was compared to Placebo in one thousand sixty three patients with neither doctors nor patients knowing who actually got the drug in a statement the NASD said an independent data and safety monitoring board overseeing the trial met on April twenty seventh to review data and shared their interim analysis with the study team based upon their review of the data. They noted that Rendez Aveer was better than placebo from the perspective of the primary endpoint time to recovery. A metric often used in influenza trials. Recovery in this study was defined as being well enough for hospital discharge or returning to normal activity level. Preliminary RESULTS INDICATE THAT PATIENTS. Who received rimmed reservoir? Had A thirty one percent faster time to recovery than those who received placebo specifically the median time to recovery was eleven days for patients treated with remedies aveer compared with fifteen days for those who received. Placebo results also suggested a survival benefit with mortality rate of eight percent for the group receiving Rim desert versus eleven point six for the Placebo Group and quote the FDA is expected to issue emergency use authorization for the drug Gilead the maker of Rim desert also revealed initial results from its own phase three trial of the drug in which it is comparing five day in day courses of treatment. The company found that a five day course is essentially just as effective as a longer course meaning the existing supply of the drug could be used to treat a greater number of patients unlike the NASD study. There was no control group. So the study doesn't speak to reservoirs. Overall effectiveness murder piracy Gilead. Chief medical officer said in a statement unlike traditional drug development we are attempting to evaluate an investigational agent alongside in evolving global pandemic multiple. Concurrent studies are helping
NAD+, Nicotinamide Riboside, and Nicotinamide Mononucleotide with Rhonda Patrick
"I'm going to talk about a molecule that has become in recent eight years extremely relevant to the field of aging specifically. I'm referring to any D. plus which I will refer to. As N de for short and some of the related precursor molecules kills Nicotinamide riboside often referred to as an R. and nicotinamide mononucleosis tired often referred to as an these two precursor sir molecules are called an boosters which can both be found as consumer available supplements. Just in case. You've never heard of any. It's probably one of the most important molecules accuweather on the planet so important in fact that without it life would cease to exist to NATO boosters nicotinamide said nicotinamide mono nuclear tied at very high doses. This is an animal. Studies have both been shown to improve the way multiple tissues and cell types age including skeletal and heart muscle brain and stem cells. There have also I've been to preliminary clinical trials in humans showing nicotinamide riboside may raise energy levels in white blood cells. which is pretty darn cool however I still? I think there are many open questions that need to be answered regarding. Ad Boosters and I will touch on some of these concerns in this episode but the possibility that intracellular NASD may be increased from a supplement or several types of supplements is awfully interesting if not downright exciting for one. Simple reason energy levels decrease with age and a decrease in energy eighty levels across a variety of types of tissues is associated with many and naming many hallmarks of aging these hallmarks of aging that are associated with age related plated changes in the pool either directly or indirectly include things. Like loss of Proto. Stasis Might conroe Dysfunction Glucose Intolerance Insulin Insulin Resistance Cellular senescence altered epigenetics and more this is partly because the availability of promotes. DNA repair capacity while its decline is associated associated with the accumulation of DNA damaging reactive oxygen species another reason is because Nada's required for energy production so when energy levels decline as they do with age this results in less energy production in many tissues like the brain immune cells muscle etc.. That means those organs do not work as well as they once insted. During youth. When energy levels were maintained? Any ideas also required for the activation of a very important family of enzymes involved in longevity called Sir Tunes and the complete answer to why energy levels fall with age is still an open question. But there's a few things we do know. As we age chronic inflammation and immune activation two processes that consume NASD tend to go up and with them our need for DNA repair placing an immense demand on our energy pool. Meanwhile while our ability to produce and recycle tends to fall with age we're GONNA cover a lot of ground in this episode but I wanNA start with an overview of any D- Any any deal has a very important role in energy metabolism and can be synthesized in the body from a variety of dietary sources including the amino acid trip to fan which which is in tons of healthy foods like salmon spinach and nuts and the three forms of niacin which is vitamin B.. Three also found in foods like lean meats legumes veggies edges these three forms of vitamin B.. Three include nicotinamide also called Niacin nicotinic acid and nicotinamide riboside they are commonly referred to as Nice in equivalents but dietary sources of energy are not the major source of any D. The major source of energy is through a recycling mechanism that we will discuss later. The reason for that is because our organs require such large quantities of that it would be impossible to consume enough from our diet. So why why do we require such large quantities of any first and foremost energy plays a critical role in energy metabolism critical. Meaning without it. You can't make energy entity participates in back and forth processes of reduction and oxidation often referred to as Reebok's reactions these alternating conversions of NFC's oxidized form which Canady to its reduced form. An Age are crucial for the metabolism of glucose and fatty acids and the formation of ATP. Since both the oxidized is in reduced forms of amd are essential for these linked sets of reactions cells need to maintain massive concentrations of both and a D. and an age basically without these molecules. Not only would we cease to exist but life on our planet would cease to exist and it is also a cofactor for many different important enzymes in this context a cofactor means something that is required for an enzyme to work at has to bind to the enzyme and this activates the enzyme so it can performance function so. Let's talk about a few of these enzymes. Several these NATO required enzymes are inside the Mitochondria and this is another way and participates in the generation of energy aside from itself being a type of energetic currency it also acts as a cofactor for enzymes involved in the production of energy from glucose outside of the minor Qendra this is referred or to as glycolysis many types of cells us look like Hollis's as their primary source of energy. For example. Red Blood cells do not have any medical Andrea so one hundred percent of the energy. They require to perform their function of delivering oxygen and other goodies to other tissues in the body comes from glycolysis and plays a very important role in mitigating DNA. A damage you need repair damage to DNA. That is because any cofactor for one of the most important enzymes involved. In repairing DNA damage called part one the activation of part one requires an enormous amount of any D for example excessive DNA damage in subsequent one activation have been shown to decrease energy levels to twenty to thirty percent of its normal levels. The ability to repair DNA damage is important for longevity. LYMPHOBLASTIC cell lines established from blood samples of humans who were centenarians. One hundred years or older have significantly higher part one activity than cell lines established from younger individuals. That are seventy years old part. One activity has also been correlated with maximum lifespan. In mammals the higher the part one activity the longer lifespan. For example the activity of part one one was measured across multiple Mammalian species and the difference in powerpoint activity between the longest lived mammals tested which were humans and the shortest lived mammals tested. which were rats? It's was fivefold so not too much of a surprise but genomic stability which relies on energy in general and pop ones specifically maybe very important morton longevity is required to activate signaling proteins knowns or two which are highly conserved enzymes play roles in health span and longevity in multiple organisms uh-huh so to ends are linked to the regulation of variety of metabolic processes like the response to stress and the modulation of lifespan. The way they do this is through EPA genetic regulation so twins utilize ad to remove specific chemical structures called seal groups.
Clean Energy's Ever-Changing Policy Risk
"In the summer of two thousand eight Britta von Essen took an internship with a major investment bank after wrapping up business school. It was considered at the time one of the top places to work it was with a company called Lehman Brothers and it was actually a fascinating summer. I was working in their global power group but focused on renewable energy and you know there was a lot going on at the time. Tax Equity was really ramping up. People were figuring out how the structuring was going to work with that. There are a couple. IPO's that were right on the horizon so it was a fascinating summer from renewables perspective and also what was going on at Leeman. It's been an unnerving week for US financial markets and now the potential collapse of Lehman Brothers once the fourth largest investment firm in the US at at that time. Lehman Brothers was the top investor in renewables it had bought big portfolios of wind and solar projects. It was a leading equity investor and it was helping take companies public it was an exciting time but as the summer war on market conditions worsened investors got nervous in things got grim for Leman analysts say the bank's future is in doubt out afterward reported a loss of nearly four billion dollars in the last quarter. Leman brothers is suffered heavy losses as a result of the US housing slump while I was there. It was just constant reassurance that that these cycles are normal and and you know financial markets go through this occasionally and everything was going behind of course it was not fine be one of the watershed days in financial markets histories. He was a manic manic Monday in the financial markets. The Dow tumbled more than five hundred points after two pillars of the street tumbled over the weekend leman brothers or one hundred and fifty eight-year-old firm filed for bankruptcy in the lead up to the Leeann bankruptcy in the fall. IPO's fell apart project financing dried up and cleantech companies beneath loans underwritten by the bank were suddenly exposed to risks. They didn't foresee. BRITTA had a front row seat to all of it. After leaving lemon she picked up and moved to Italy where she helped build wind and solar projects for a German developer soon after she witnessed yet another period of chaos the swift rollback of feed in tariffs the Italian market came to a screeching screeching halt. It did teach me a lot about developer resiliency the fundamental optimism that is required to be of renewable energy developer and and taking the long view on a lot of these projects so British took those lessons and apply them to the next chapter of her career. She now advises clean energy companies knees on how to manage risk so you've managed to witness the collapse of one of the biggest investment banks and one of the biggest European renewable energy markets back to back. That's quite an entrance into the industry well. I swear it's not me I'm not the not the driver and all of this but I think what it taught me was that things change and the markets move and those that are resilient and those that figure out how to work in the new paradigms that they're given are the ones who are successful so I've taken a huge amount of those lessons into my current job and into my current business where I'm basically advising folks how to roll with the ever changing markets that we see in wind and solar. I'm Stephen Lacey in this episode produced in partnership with Cohnresnick and cohnresnick capital talking talking with British Ivano sin about those ever changing market conditions today Britta's a managing director at cohnresnick capital over the last decade. She's seen all kinds of market risk mostly expiring or changing policies that create financial risk you know I it was the sixteen o three grant expiring then it was. ITC expiring PTC's stepping down. What are the safe harbor policies we we didn't even get the IT safe safe harbor policies until fairly recently. I think it's just a fundamental aspect of this industry. It's Salat about planning for the unexpected in British. Job is to help figure out how to get renewable energy deals done in the face of those challenges so I sat down with her to unpack some of those policy uncertainties and what they mean for renewables and I wanted to know how often does policy change derail projects so I have. You've worked on project many projects that were potentially derailed that we manage to work around various policy changes. I think change in tax law was a really interesting time where we had to figure out how to keep the investors active of an investing in two projects that would probably not be commissioned for another twelve months and how to get around the fact that there was a very likely change in tax law to be passed at that time and yet nobody knew exactly what that was going to look like. I think this PG bankruptcy recently and the California I think it was a be ten fifty four the wildfire response bill that has been high in the mind of a lot of California developers at the moment who were focused on contracts with sce NASD Johnnie and whether or not those credit ratings. We're GONNA take ahead that policy was passed and I think both of those organizations are are quite secure and short up and that was that was great news for California winging developers across the board with or without contracts well. Let's walk through some of the big drivers and uncertainties around them so you mentioned. PG Ag any I'd like to talk about PG and understand. What are you now looking for in a bankruptcy proceeding what kind of risks to contracts tracks are there currently what has been sorted out and what's still left to be sorted out that would impact renewable energy developers so I believe there is still still quite a bit of uncertainty as far as the potential for PG any to cancel contracts that are considered out out of market today so these would be some of the earlier vintage. PPA's there are several conversations and I know cohnresnick has been a part of several several of these about trying to restructure this through bilateral negotiations with pg any and kind of nipping in the bud lead and coming to a good solution for all parties but otherwise I think there is still a strong degree of uncertainty here there there are investors who are then making plays in this and trying to pick up these assets making a bet as to whether or not there will be restructuring of the contracts are not as as well as you know. It's an unfortunate situation but it's certainly a very active group of projects and sponsors that are figuring out working working through how to navigate that uncertainty. Let's go to tax equity. The solar investment tax credit is now facing the beginning of its step down schedule this is obviously going to impact the economics of project development but we have had some clarity on this step down unscheduled for for years now how is facing down the IDC GONNA change the way projects are financed and does it present any risks that were not there previously so you're right. There is a very clear step down schedule which I think has been helpful for folks trying to new forecasts what this looks like that being said given the safe harbor provision. I would venture that there is a generic assumption option from those who are procuring. PPA's at the moment that their assets that their projects will be safe harbored many of the major. I pee pees Jason. Strategic are making significant safe harbor place. They are you know doing this both for their own projects jags and under the assumption that there will be Ebony advantages over the next few years which I agree with. I think a lot of these developers that are procuring making this assumption are going to limit themselves to buyers of the assets that can then fulfill the safe harbor in order to meet the Economics Amax. What do you think the chances of an extension of the investment tax credit are. I know that the Solar Energy Industries Association has all of a sudden and put this back on their priorities list. They think maybe there's an opening to extend the federal tax credit. What do you think the chances of that arc given what you know so there's a couple a couple aspects of this that are important absolutely it would be beneficial to the industry right that being said we are months away from the step down last time this extension happened. I think we had a good twelve months of lead time so it allowed loud folks to plan at least partially accordingly in this case you would actually jam up probably some more some of the more major players who have made significant safe harbor plays that would have been capital that was not necessary to deploy a and potentially at pricing that is not beneficial to their assets so there are mixed mixed feelings throughout the industry about this. I think there is a decent chance I also think it's interesting giving kind of the economic markets at the moment and the potential for a downturn. Let's call it in the next twelve to eighteen months renewable such a critical component of job security and job growth in the US economy at the moment that especially if we're facing some type of downturn it may increase congressional and government support for some type of extension here. What about the storage tax credit. That's been floating around Congress for for a long time if there is this renewed push for potential solar. It see where does the storage. I T C fit in there would would it be something separate. Would it be wrapped together. And what do you think the chances of getting this thing finally pastor. I think the storage credit is actually much more critical critical than the than the solar one in the in the near term here I think with Alda we will continue to have murkiness around trying trying to loop storage into either wind or solar tax credits which is is just messy. It's hard for investors to get their heads around it. Just adds a lot of confusion and it also limits what you can do from adding storage onto existing renewable energy projects objects. I think throughout the energy community there is a consensus that storage is a critical component that needs to be deployed on a large scale will in order for renewables to continue on the growth. It is an in order to hit. Some of these are targets hundred percent in California boring. If for example you you have to have the storage component there otherwise you're facing you know a variety of issues on you know intermittent see or demand or any variety of aspects so. I am a little more bullish on the storage tax credit. I I think a standalone tax credit does a lot to simplify and streamline financing aspects for storage whether or not it connected to renewables and whether or not commissioned at the same time as the
Older Mice Experience Delayed Aging, Longer Lifespans When Given Blood Protein From Younger Mice - Study Finds
"All right. Could an injection of young blood be the fountain of youth wasn't there a company in California who was selling for thousands of dollars a infusion of young person's blood. Well, there might be a little science behind it or being told that buddy is claiming that an enzyme from younger mice. Extended the life span by sixteen percent for older, mice proteins called. E. N. A. M. P. T. Received it. Lived longer. Scientists say the protein. We're getting older mice received injections of the protein from the blood of younger vice they saw their confident function, improve have better sleep quality and their lifespans extended by nearly twenty percent. In humans. This is the equivalent of life expectancy being extended from the age of seventy nine to the age of ninety one. Oh boy, I could just see the stocks go crazy. The team from the Washington University school of medicine in Saint Louis St Louis said that the findings indicate that this method could be the secrets awarding of age associated diseases and be an anti-aging method for humans. And the enzyme is known as E. N. A. M. P. T E napped. So they say he plays a role in how cells produce energy as a body ages, however cells become less efficient at making this energy. They say we think the body is somebody redundant systems, to maintain proper any D levels NASD is the energy that they're discussing and this senior author, Dr shin is hero in by says, since we know that NASD inevitably declines with age many researchers interested in finding anti aging interventions that might maintain an levels as we get older for the study published in the journal cell metabolism. The team gave one group of older, men older, mice concentrated eat and AM inapt taken from younger mice and the other group got a placebo sailing, not that you really need to do placebo with mice. It's not like they know and the mice in that got the saline solution all died in about two and a half years. But the mice that didn't live for two point eight years. So lifespan increased sixteen percent and it's better than better, cognitive function on memory tests. This is
"nasd" Discussed on The Peter Attia Drive
"Search wins and parts, and it can only make any D before it does anything else. And again, this is a flux thing. Right. It's not like it's not like the liver says, okay cells tell me what our balance of any D N N is on Friday and on Saturday on the decision about how much to empty into the urine. This is an immediate thing. That's happening right now. Deliver says okay, got two choices. I either to talk this or I do something useful with it. And so if you're presenting it with that thing that's a threat, and it has to make that decision. It can only make so much any D at once at one time, then you're gonna have much more waste in the detail vacation pathway, then if you put the thing in that has to make an that is not a threat when it makes eighty and that has to actually generate any to ever. Be exposed to the deduct vacation pathway, so you have to appreciate the central role of the liver in controlling the flux throughout the entire body. The liver's not just making any deferred self. It's making any D because it carries all of the reserves for the rest of the body as AD, so the liver doesn't just have any d that's immediately being used in respiration in his immediately being used in search wins in parts, it has a reserve pool of NASD that it holds onto for the specific purpose of a slow release of nicotinamide to the rest of the tissues that they will take up, and then they will have the immediate decision to either talk to fight or make any D. But if the liver can hold on safely to the NASD and have a better ability to release nicotinamide on an as needed basis and a continuous basis. In a at of rate that the other tissues can take up and do something useful with then because you got a superior way of increasing. Hip paddock any d you got a better continuous flux that was optimized of nicotinamide to reach the other tissues. So they can make any. Yeah. So in that sense. It's actually sort of parallels. Glucose, right in the sense that we have we have to maintain about five Rams of glucose in our bloodstream at all times. So if you have ten grams of glucose in your bloodstream, you have diabetes, you've got huge problems. You're gonna go blind and get your toes cut, not if you have a hundred grams in your liver. Exactly, but five grams is perfect. And if by the way, if you have to grams you die, you know, it's just it's an amazing problem where the liver is constantly titrate..
"nasd" Discussed on KNST AM 790
"It's our job is to cut through the talking points. Martha McCallum we're going to ask the tough questions because there's a lot of conventional wisdom out there that needs to be challenged human breathe. What I'm doing is making sure that whatever is developed through the day. People are fully informed from coast to coast. We're twenty four seven news. But really down to the minute. We're going to be fearless. We're going to be fair. Whether it's for AM midnight were there, Fox News channel real news. Real honest opinion. Arizona politicians are surprisingly mixed in their reaction to President Trump state of the union address. I'm Greg Paul. Kane is t- news Republican congressman Andy Biggs felt the president has made significant progress and keeping his promises to the American people democratic congressman Ruben guy is not as enthusiastic he calls the president's border wall. A ridiculous monument to division and hate most of the female democratic lawmakers wore white in honor of the one hundred anniversary of women getting the right to vote women's suffrage, but Arizona Senator Kirsten cinema war hot pink. The Arizona department of transportation is expanding a program that says makes our roads safer while boosting the state's economy. Eight Tom Herman says under the international border inspection qualification program. Inspectors go to Mexico to give trainings on how to prepare a truck for inspection in Arizona. He says that encourages those truckers drive through the state and spend money while they're here. You have all of the businesses across the state that support the trucking industry from. Tires to guess, a lean to mechanics, they all benefit when they're more trucks that come in Arizona. He says the three year old program has also made inspection requirements uniform at all ports of entry that seven ninety K NASD's, Don Nici reporting, and after administrators told students they wouldn't provide a venue because of religious differences in a high volume of rhetoric. Grand Canyon university is now extending an invitation to conservative Ben Shapiro to come speak on campus later this year. That's according to a statement released by the Phoenix based Christian university university administrators say the invite will have Shapiro come visit sometime in the spring..
"nasd" Discussed on The Peter Attia Drive
"And that's where I really stand. And it seems to me that. Intravenous administration of NASD. Also, not particularly helpful though. It seems quite popular in the sense that I I'm not I haven't seen compelling evidence that giving an intravenously makes its way into the cell either. So I think the development interesting development will be to develop a drug and the drug will be precursor that will get into the blood outside of the liver outside of the liver guy. Exactly. So if you could give an are subtly or intravenously that strikes me as very interesting saying that there's a lot of data in rodents. Where also you look you give it in different ways, you give it summing water, but some are vase, and maybe that's different because one of the problems that maybe if you go deep enough, you can bypass the by circulation ride, you can bike something. So, you know, but the Viva studies are. Good studies. Okay. You just don't know what it means to you men's well narrow time check here we've been we've been going at this for a little while there's a lot more I want to sort of pick your brain on. But we also just sit down into this again sometime I wanna make sure you've said at least as much as you wanna say about metformin because I think that to me is, you know, you're you're at this point, arguably one of the world's experts on a drug that just to put this in perspective. I think Lou Canley who's obviously a close mutual friend of ours. And James Watson who I don't know. Personally, have both said quite publicly that metformin may have already saved more patients lives from cancer than all other cancer drugs combined or something to that effect. This is a drug that I think with each passing day more and more people are beginning to learn about beginning to ask questions about. And my hope is that if nothing else this podcast is a place that people can listen to this episode if they. Can't go and read sixteen of your papers. And they don't necessarily want to get you know, that far down the rabbit hole. But to hear it from you and not for me or some other schmuck who doesn't know much. I wanna make sure that if there's anything else, you wanna say about metformin that that you say so and so is there anything else that you want to add let me do one truck tickle thing in one a little bit more philosophical..
"nasd" Discussed on Bulletproof Radio
"Use that are going to give you more energy. And we're going to talk a lot about energy in the show today because he's done a lot of work with some of the newer anti-aging supplements. Which is the other is on the show casper. Welcome to the show pleasure to be here. Dave, and that was an excellent intro. It's always funny because you work with a company that makes natto vim, which is a supplement that contains NASD and people have read headstrong know about an as part of the electron creation and recycling system in your cells, the mitochondria it's critically important. They've heard me talk about how I've done intravenous in D. And how important it is to take a deep precursors? And if to take eighty itself, so you focus on that stuff. And how the heck do you translate that to someone who doesn't know what in eighty is? And you say things like I'm looking to insert some marketing buzzwords here, but I'm just gonna go right for it. Why do you of all the things you could do with the the set of knowledge that you have why did you go for focusing on NASD as the low hanging fruit for creating wellness and people? Yeah, it's an excellent question because there are so many things out there, and we do. Have this tool kit, especially at our medical clinic that that there there's so many different therapeutic options, so many different interesting ingredients, and why single out that one I think it stems too when you look at the population, and you look at what's going on right now there is this basic crisis of brain energy, and it's affecting everyone. It's it's really affecting the population of patients weasel, even if it wasn't a brain type of disease. We still saw that the brain was affecting the brain's incredibly important in mediating all symptoms also going to the root causes in getting someone back to healthy. So when we started to look at it, right? How do we truly improve the rain? And how do we address it in a way that goes after the modern day pieces, which are throwing us off? We have so much stress nowadays we're living in a different time where there is social media. There is this information overload where we have more toxins than ever in our. Just our food sources, and then we're really really pressured by these things, and they're mostly impacting not just us on the cellular level, but also on that brain level. So when we looked at it that instead, we're seeing this crisis of brain energy. What's the one piece there if we could hone in on one, and we never liked to do that? Because we like to look at things comprehensively, and everyone is different. But if we were to single out one piece in there in one piece that's being depleted at alarming rate. It's NASD and this is something critically important to every single cell in the body. It's probably just as important as oxygen is. And without that with that depletion of NA. D you're going to see a host of symptoms even in healthy people, the brain fog, the the loss of memory and baby boomers and in patients with neurological conditions that's an element factor in there as well. So when we looked at all of that we were able to say all right? We want to put something out. They're not just for patients, but also for the general public to really help. And where can we do the most help? And we started with an now NASD is a compound in cells that takes an electron made by the Krebs cycle in basically moves at around. So if you're making enough energy, but you've got nowhere to put it in. No way to move it. Because essentially, this is not. Not chemic- or not physically accurate, but in terms of a picture in your head. It's useful. Imagine if you had a giant generator that can make enough energy and had enough fuel. But the wire coming off of it was very very thin. You couldn't carry enough of that current to do anything with the electricity made?.
"nasd" Discussed on Ben Greenfield Fitness
"So they can just do a four. Yeah. Okay. So the next question that I have for you is you also have this thing called brain, refuel, is that also an Ivy. Yeah. So brain, refuel is really the combination of an inter inter Venus entity, plus plus the fast vitamin and so years ago when I got my hands on the NFC protocol, and if we back up a little bit, you know, NASD be three vitamin derivative. By and large is used mostly in this country for addiction. That's how it grew up from the nineteen thirties. Actually that was the science then was helpful for addiction really turns off cravings. Whether we're talking opiates alcohol, you name it almost better than anything. And it does it quickly. But those protocols were very long arduous ten straight days of intravenous entity in each protocol lasted excuse me. Each day would last six to eight hours, which is crazy. And so when we got our hands on the protocol, the first thing, I did was say there's no way it's gonna be feasible for most people to get the benefits if it's gonna take six eight hours people just won't come back to the office. And so we did a lot of testing in my office. Again, I I'm lucky I have a lot of patients who like to experiment, try stuff. And so we played around with all the different dosages and came up with what we call what we think is the sweet spot in terms of doses. Where people will get the benefits, but be able to tolerate the IV in in really. Most people that drip takes about an hour hour and a half. That was the first big change we made, and you know, if you talk to the people the original people who brought the NASD IV protocols to this country, and there's there's one gentleman in particular who who purchased the distribution rights for any d- back in around two thousand five or after at that time, there's only one company in South Africa, making N G and injectable entity. And the thought then was that any D has to stay in the body or the only way it'll be effective. Is it stays in the body as long as possible, and we don't we don't believe that to be true at all that doesn't make much sense. So we, you know, we encourage people to go fast as they're able to for most people works out to being out or hour and a half. That was the first change. We made the second change. We made was energy cannot be mixed with any other nutrient. We put it in Stanley, and it has to drip in. But then we we pushed at the end the fast vitamin which has a host of really like. Amino acids things like loot Amine acetyl L carnitine, which help transport the NASD into the mitochondria or into the cell to get to the mind conjure. And so that's really what brain refill is is our naming of the combination of injury entity in the fast, vitamin push. That's exactly what I've been doing. So I do the NASD once a week, but as soon as the NASD finishes up, and I realized that that again as I've already worn people. This is not something I endorsed doing. But I literally just unscrew the same syringe that I used for the NASD and screw in the fast vitamin IV ended that same butterfly needle. And then just just push it in right after the whole thing start to finish takes me about twenty twenty five minutes to do. And and you notice a big difference. When you follow up the NASD with the IV, you still notice quite a bit with just the NASD..
"nasd" Discussed on Ben Greenfield Fitness
"The day on four to six hours of sleep. When I'm using these NASD IV's, and it's it's almost unfair. So I don't wanna make this sound like some big sales spiel for issues, but I'm just you know, kind of backing up. Any goals? One experience. The I've had. So I want to talk about these ingredients like what's actually in these issues. What are the actual formulas that you use? And why? Yeah. So we'll came about we used to do a lot of IB he Latian with calcium EDTA and those IV's were three hour protocols people sitting in a chair for three hours and a long time ago. I got my hands on the European administration of calcium ETA, which is three thousand three thousand milligrams push. That's ten second push. And when I started you that this patients felt better their laps reflected much being my office for for three minutes versus three hours. And so I started thinking, you know, and again this time people were doing these vitamin IB's like they are now wasn't trendy weren't all these IB centers. It was people who were sick people kind of fifteen things like that. So I thought we've got to be because these ivy's works of other feB res away. To do this proactive, Lance that reactively, and I'm lucky I have a lot of patients who like to experiment. We just tried it out in terms of different nutrients, and you know, would use a hosted different vitamins, minerals, lots and lots of we know acids, and we just tested and by tested years in years, thousands of thousands of patients really documented what works and what doesn't work. So Craig we were just getting into the actual ingredients of these IV's because if I understand correctly, there's kind of like some different mixes for specific goals, and I'd like to take a deep dive into these actual formulas and what they're designed for. Sure. So, you know, some of it was based on since we do a lot of nutrient testing, you know, the three big arenas where people are most of or most commonly deficient would be vitamins minerals like magnesium, and then amino acids, and so when I put this together, I thought let's let's shoot for the low hanging fruit. Route because that's what people need most. And we also wanted to use things agents that are water soluble because you know, we really don't want to deal with anything in. Honestly, it's you can give fat soluble nutrients intravenously? But you're talking about a central line and things so gets it's so much easier. Just to do with water Cybele nutrients, very very, very safe. Meaning there's no ceiling in terms of a lot of these things we could see you can give you know hundred thousand two hundred thousand milligrams. If you do it, right? You're not going to run into any safety issues. So the core of all the formulas. We have has those three arenas included a full array B-vitamins so be complex which has led him and B one B two B. We use a lot of vitamin B five primarily because a lot of people walking around today or stressed out. And have adrenal issues in vitamin B five seems to be the most important b vitamin for adrenal health. We use some vitamin B six we use methylated b twelve kinda rounds out the B vitamins. Okay. By the way, is in vitamin b twelve is not nicotinamide right beside your thinking of vitamin B three. That's right is vitamin b three niacin or nice cinema, and we chose Nias cinema. I'd which is like a chemical cousin to niacin because nyah cinema. There's a host of data saying held it helps with mood better than just niacin. So nice cinema. People. Could you know, people are thinking about taking something you could take nice cinema it orally and get a nice bounce.
"nasd" Discussed on Ben Greenfield Fitness
"There really should be some freedoms that doctors and compounding pharmacies and patients have when when when they're really desperate and they don't have anywhere to turn to. You know the silver, for example, silver IV's is alternative to these these antibiotics, and that's being threatened to come off the market. The Moore the from from, you know, the three wise men. I mean they've taken for, they really want it if the wants to go after merger would emerge you. So, I mean, it's really just the sort of threat to all the other potential sort of NASD therapies out there, the making and to healthcare costs. And so that's that's really, and I really think the FDA's really the biggest obstacle to to longevity. That's what I wrote. So. Okay. Well, I want I want to get into Alzheimer's second, because I know you've been looking at that quite a bit in both. You guys have some some, some pretty big thoughts on a multi modal approach to Alzheimer's and we can do about Alzheimer's. What before that you had briefly mentioned article that I sent to you, Tom about an uptake and this this one I will link to in the show notes over Ben greenfield finished dot com slash plasma, but it does show that most. Mammalian cell types can transport in a d across what's called the plasma membrane from the extra cellular medium and into the cell and it. It does actually show a pretty significant amount of NASD uptake despite the people that sell the NRA supplements, which I have nothing against those ourselves at work, but but a lot of folks will tell you in d..
"nasd" Discussed on Ben Greenfield Fitness
"Slash and are you can listen into it. What is your opinion on on injecting in a d either inbetween. Limitation of NR or just in injecting in general? Well, you know, I have seen the data. They're not really, you know, clinical data, right? They're they're, they're more like observations of people that either were drug addicts or alcohol, abusers, or in in other cases, kind of performance nuts, like yourself that that wanted to to try injectable in a d and you know the personal accounts are, you know, are are very impressive. The thing is in a d, it is a class of of it's an intracellular acting coenzyme. It has to phosphates on it and compounds with phosphates, don't get into cells and is not a drug, and and you know any d has profound effects inside. Side of cells, but it cannot get inside of of cells because it has the two faucets and and pretty much any. You know, biochemist pharmacologist knows this. There's antiviral drugs of the same class of molecule. They're called nuclear tides. There's anti-viral drugs like AZT that isn't that's a nucleus side and people take it as a nucleus side. It has to be converted into a nuclear tied inside of cells. AZT phosphate doesn't work right. And so when when people are taking injections of of of any d. it's almost certainly being degraded to nicotinamide rival side and to an are, which are then going into cells. And we have a paper and I presented it in San Diego at the so-called a d, two thousand eighteen summit that was organized by a group that kind of. You know, runs a clinic and AD injection clinic, and I showed data that we did a direct trial of NASD versus and are on a on a brain lesion in a mouse. So we induced excited, toxic brain injury. You know, I'm sorry to the to the mice. But you know, this is the scientific process to figure out whether things work. And so we induced excited toxic brain injury to to these mice and directly compared, you know, infusion of our versus infusion of any D. And any protected. But it took fifteen times as much and a d. to protect against the lesion compared to the efficacy of the of the in our why? Because an Argos right into those neurons and any d. has to be degraded back to our before it can be used. By the intracellular nicotinamide right beside as is so injecting a AD doesn't really make a whole lot of sense to me. It may work, but I don't think it's unnecessary. Have you injected it on an. They know. But what I have done is I've suggested to this to this group a clinical trial design crossover trial where they think that you know NASD is so f- acacias for drug addiction that they think it's not ethical to do a a placebo arm. And I said, okay, well, but you've got a unique that caliber of data. If you wanna change healthcare, if you want to change clinical practice and get people to. Be able to benefit from the profound effects of any d. that you you say you're your patients are observing, you have to do an accepted type of clinical trial in which you have to compare it to something. And so we suggested that I suggested that they have an NA d, you know, injection arm and those people, you know, switch over to oral and are, and then they have oral and our and those people switch over to injected any D. And you know if high dose oral and our does, what in injected any does, then you know you're going to get that result. And if you really need the injected entity, you're gonna, you're gonna get that result and everybody will get the injected any d either first or second, but they won't know which, well, I'll tell you, I'll tell you this because I know I know we're running up on time here pretty soon. I'm gonna take what you said about these two phosphates causing NASD to not be able to. Org by the cell. I'm going to ask a couple of these folks. One guy who actually sends me my NADA IV's obviously bias, and the other guy runs the injection clinic. I must see what what they say about this and for those listening..
"nasd" Discussed on Ben Greenfield Fitness
"And when the digestive process, we're gonna digest down the NASD, an EPA h into vitamins. Vitamins are precursor molecules of co-enzymes and so and are is the largest piece of NA NASD that can go into a cell and replenish your energy. The n. r. could further breakdown to nicotinamide or nicotinic acid which were discovered in nineteen thirty eight. They're not quite as valuable as an r. is as an entity precursor vitamin, which is which is kind of why there's so much research on an are right now. Interesting. So we covered the five. Five right that that we, that we encounter, you know, without disease alcohol, overnutrition noise son an oxygen damage and changing time zones. And then the the two or three others that are that we've basically discovered by we another's by doing research with with animals, nerd degeneration. So inert degeneration. Any d is under attack both in peripheral nerves and in central brain injury in heart disease and a d is under attack. And in aging, there's a, there's a decline in tissue in a d in the liver and in in in some other tissues. And and so essentially, then you know, if you whether you're a consumer or your, you know, an advanced research scientists. If you come up to me with a question and you say, hey, I wonder if my, you know favorite disease. Or condition, whether it's, you know, chronic fatigue syndrome or some immune activation phenomenon or something with stem cells. I wonder if condition x, y, z affects the NASD system. There's a very simple way that we can figure that out right now, which is you give my lab, you know a tissue sample, and if we see that these metabolites NASD or any DP PH and some of these other metabolites are dysregulates. Than we know that the NFC system is under attack. That's the first technology. And then the second since since my lab kind of finished and a few other labs finished discovering the the hidden genes in the gene said, we can now look at the gene activities in these tissues. And for example, heart disease was amazing. So in heart failure, NASD is down and the nicotinamide right beside kindness to gene that we discovered in two thousand four that gene is up. So what does that mean? It means that the failing heart is losing an and it spiking up the an our pathway. So the failing heart wants and are in order to get its NASD backup to normal. And if we give those mice oral and are we can, you know, make their heart disease much less severe. Even though there. Bred to be genetically predisposed to this particular type of heart failure, seeing the same thing in nerdy generation central brain injury, any d. goes down the NRK's pathway and our Kate one in or k. to in that case, both go up and then you can protect the brain with an are. That's fascinating. Does do you think that in non diseased populations or people who don't have brain heart damage, it could just be used to improve cardiovascular health or to improve cognitive performance. So so there's clinical testing to, you know, answer that exact question, so I'm not somebody that goes out there and and you know, advocates injections, and you know of anything. But I, I will. I will address Ann Arbor AD because we've done a brain injury, experiment that directly address that. Okay. I, I actually, I want to hear more about that. But before we we. Delve into that first of all, you mentioned that for somebody if they wanted to test how much AD they had, they could, for example, send your lab a sample of their other tissue. Is that something that's commercially available? Well, you know, right after you know this podcast interview, I've got a conversation with some folks at at Chroma decks and a potential partner to to do that for kind of early adopting community. And you know, we got to work out the, you know, the regulatory pieces of this, their volunteers, and I'm not giving them, you know, back a health advice, but the technology is there and it's, you know, it's not particularly expensive to measure in a D. And a blood sample. Keep me posted on that by the way folks. If if you're listening in I'm gonna keep track of all the show notes over Ben greenfield thinness dot com slash and our that's been greenfield than his dot com slash en are..
"nasd" Discussed on WGN Radio
"Then you check them out the ast and the the sec publish reports about advisors and if they've been sued for doing bad things or if they'd been hit by the sec for doing things that are bad if they're really bad they don't let you serve clients anymore but but there's plenty of information about complaints have been issued against financial advisers and other material about what they've done in their published media that you can get online from the sec website or the nasd website to track down these people and here you're seeing what their reputation is at least knowing that they weren't ever accused of wrongdoing it sounds to me like there's a little bit of homework you have to do but the referral should be the starting point always yes i think that i there's so many people out there and they the skill sets there's no one rule that says in order to to be a financial adviser you have to do this or this is the service you have to provide there's differences in some planning firms they they even go so far as we really prepare tax returns we help people to stay planning we we help them with their investments we help them with their estate plans how to set up charitable foundations how to set up trouble with council the level of service varies from firm the firm and the expertise and the experience of the people within those firms here's the million dollar question for you and that is what's the level of income that we would see for getting a financial adviser is it somebody that has a million bucks he's at somebody who just has a little bit of money.
"nasd" Discussed on Bulletproof Radio
"And we can basically put it in a machine and we can determine the levels of all of the energy metabolites with these two technologies can basically tell us whether any ideas involved in any process that you want like you know chronic fatigue syndrome someone asked me about that recently and he said you think eddie might be dysregulates and in chronic fatigue syndrome and i said well i don't know what i know i can figure out how we can tell which is you know just get some tissue and if we see the genes are dysregulates at the metabolites are disrupted is telling us that any the is miss regulated the most amazing thing one of the most amazing things that we did in the last year religious this heart failure story that i was telling you about where this mouse is on its way to getting heart failure it's it's even presymptomatic and it's any d starts dropping and it's any dropping and it's nicotinamide riva's side kindness to gene is spiking up so the the gene pathway to convert an are into any going up while the nasd is going down and turns out what turns that on is something called amp chinese so it's this low energy sensor and the low energy sensor is turning on this end our pathway so that if you're if you're the lucky mouse who is supplementing with nicotinamide rival side you have a much better heart function because at ours available to those stress cardiac cells that are having the spy winter jeddah crisis so to some degree people will have a a more noticeable performance issue after they're they're all already you know somewhat debilitated but there's a protective aspect i think of having an are available when stuff.
"nasd" Discussed on Bulletproof Radio
"All right that's a great use case that's cool yup yup son you know son and oxygen damage reactive oxygen species so when you talk about the mitochondria dysfunction then you're talking about you know electrons gone wild and electrons go wild they generate reactive oxygen species and they require any dp h to detox them any the ph is also required to make things like estrogens and andrew jen's and so you really don't want your enemy ph tied up in repair processes when you need it for bio synthetic processes changing time zones and timezone disruption dysregulates the nasd matab alone because the nasd metabolism is regulated by circadian twenty four hour functions so we're up when i'm in a large group of people i asked you know people how many people would like to hop on a jet and go to these a for a few days as of drinking wine and enjoying plenty of food at listening to maybe loud music in the sun in the fresh air at everybody raises their hand well you just talked about five enjoyable things that all dysregulation late are any the metabolism and that's not even you know disease processes then we get into a generation and heart disease there are acute situations or any declines and we recently showed in a mouse model of heart failure that not only does the nfl decline but the nicotinamide right beside kindness gene gets turned on so it turns out that in a failing heart the heart wants to have an are in order to replete in order to fill up to a an stores why because it costs less atp to generate an from an are than from the other precursors.
"nasd" Discussed on Bulletproof Radio
"Going to take it head on but i gotta take it in okay the i trust the story so so so so nasd is the central regulator of metabolism right there's actually four and a d coenzyme 's and you might read sometimes when you read about any deal sometimes they'll say any plus right and sometimes just an eighty there's actually four different coenzymes n eighty plus an h n a dp sometimes aplus and na dp h these coenzymes are essentially required for all the metabolic transformations that occur in every cell in every tissue you die without them straight up you die with you wouldn't live without them there is no life without them right so conversion of our fuels protein fat and carbohydrate into energy requires na nasd similarly maintaining our blood glucose at night and generating tones requires nh and actually riach sizes any d h to anybody plus is also reoccupies to anybody plus when we make atp from that fuel that we eight and this is required for all of our muscles to work and for ideas to be transmitted along our nerves and for us to hear and then this entity p entity p h is required for making dna an ra and lipids and also protecting us from reactive oxygen species so the connection between an a d and longevity really has to do with two or three things one is resistance to molecular stresses like reactive oxygen species sunlight damage oxygen damage that can damage dna and other macromolecules in addition all of the nasd dependent processes like converting fuel into energy and repairing dna and maintain the are.
"nasd" Discussed on Bulletproof Radio
"Wins and ser to these longevity promoting genes that are found in everything from yeast to human beings folks were starting to manipulate the nasd pathway to see if they could extend the lifespan in something like a yeast cell and when i looked at the evidence basis for how an is made even something as simple as a yeast it seemed like there could be some missing steps and essentially when we knocked out the gene that i was working on we found that there was another way to make any d and that was through nicotinamide riboside so that's when we discovered an are as vitamin and the nicotinamide riva's side kinds pathway to any d back in two thousand four and so this is going back a while and this is one of those kind of unusual supplements that year outs are on the corners of the internet around longevity and given that i'm looking to live to at least one hundred eighty maybe a little bit longer or a lot longer actually i'm completely willing and able to find everything and try everything all at once to see if it works and this is definitely more things i've been aware of for a while and i've i've taken on and off over the years and i'm thinking for for people listening do you believe given that you're very well qualified understand what was going on biologically de believe that by increasing in d in our in our bodies that it we have a reasonable chance of extending our lives even a little bit let's take a step back and talk about what any actually does all your enemies and come on come on.
"nasd" Discussed on Dunc'd On Basketball Podcast
"Ad not a guy who's really setting up others that much also the variance for a d is something as the highest variant star in the nba so it'll just have some real clunkers sometimes you know in part maybe because you can't get him the ball as easily eighty just more dependent on l ucs offensive rebounds and stuff that he's just not quite able to create himself certainly has been pretty good defensively a this year and he said is gone to another level of late before spraying his ankle so we might even feel differently about him if he can keep up that level for another few weeks lead the pels the playoffs but i think for these guys they just eat them only have one playoff series in their career right now they both have pretty severe limitations to their game even authencity at this point jaanus with the jump shot a d with just you know not being able to create as much himself not really do much from a passing standpoint so that's why had them a little bit below these top guys these top guys all played deep into the playoffs before lead teams deep in the playoffs i just can't quite go there yet with the honest nasd even though you can certainly make the argument that both of them have been better than say kevin durant certainly and maybe even lebron on a permanent basis this regular season one other point which i used against anthony davis at least in the regular season is his reluctance justified as it is to not play center or his reluctance to play center and he would be more valuable there it would allow team to play more spacing he can defensively he can hold his own there and it changes the way you have to build your general about i'm not saying it is unjustified but it from a value proposition the fact that by and large you're playing these two guys who have the volun their hands different amounts and janas can create a little bit more your functionally playing and at the same defensive position i think that saps just a little bit of eddie's value now if he plays center in these playoffs a.
"nasd" Discussed on KMOX News Radio 1120
"Think you might look elsewhere there is a mutual fund that has both of those descriptions in its title the l j m preservation and growth fund i'm i i want to know how that was even allowed to be because they have to get approval from the sec and any as dna i guess is at the nasd any more be finra i guess i don't know who actually approved the titles of mutual funds but somebody does but preservation of capital and growth that there's a little that overlap but not a lot i know when i use the term when we want to preserve capital we're looking at probably some cds our the having money in cash that's how i too find it i think most people would and then there's your money that you want to grow within then there's kind of in between growth in income let's say a little bit of both perhaps what could possibly go wrong with the ljm preservation and growth fun when you read the prospectus and you try to figure route will how are they trying to preserve capital and grow at the same time well they would buy stocks but then they would sell naked put options now for many maybe most of you you have no idea what that means again google is your friend if you really want to know look it up but i'll i'll give you just the most simplistic answer you when you sell options you're are getting a little premium so you're getting some income which is great but you're also betting that the market is going to do fairly well and when it turns the other way on you you not only lose money but you know theoretically your losses are infinite you know if you buy a hundred shares of abc stock the worst scenarios you lose your.