Aired 2 weeks ago 3:22
PBS NewsHour | KQED Radio
Lawmakers grill pharmaceutical executives over drug prices, but CEOs avoid big pledges
From the news
Aired 5 months ago 63:24
How Impact Investing Can Reduce Maternal Mortality
The Merck for Mothers program and Karma Healthcare in India show how technology and partnerships lead to improved health care outcomes for women.
Aired 4 months ago 12:42
Beware of Stock Tips. Do your Own Research with Alexander Burstein
Alexander Burstein works in the pharmaceutical industry, first doing a sales career in Merck KGA and Angelini, then a marketing career. And the last 18 years, he is in business development for Sanova, a company of the McKesson Group. In his leisure time, he loves to do sports like jogging and hiking, and he is a passionate historian. In this episode, Alexander shares his worst investment ever story losing 90% value of his biotech stock investment. Relying on stock news and tips only and not researching further about the investment. “People, in general, tend to overvalue the positive information and to undervalue the information about risks.” - Alexander Burstein What do you want to hear from the My Worst Investment Ever Podcast? Tell us here! Topics Covered: 00:46 – Alexander Burstein’s professional and investment background 02:30 – Sharing his worst stock investment story venturing in a rising star biotech company with Phase 3 Projects. 03:43 – From 2000 Euros to 200 Euros: Biotech Company’s stock price crashed after the Phase 3 Project results announcement 06:20 – Andrew’s summary of Alexander’s story 09:30 – Andrew’s strategy to minimize the risk to a stock with a binary outcome 09:53 – Alexander’s one actionable advice listeners can take to avoid suffering the same fate: Divide your risk by investing in several assets. Main Takeaways Lesson 1: “I trusted news about news. I listened to people telling news about those shares. But I did not spend the time to really make own investigations.” – Alexander Burstein Lesson 2: “If you had done a lot of research it's quite possible you could not have come to the conclusion that they were going to fail Phase 3 of the trials. Why do I say that? Because there must have been other professionals and analysts looking at the company. And if they thought that there was a high probability or probability that this company was going to fail they would have been giving out warnings or turning their recommendations negative.” – Andrew Stotz Lesson 3: “The number one error that most people make which is a failure to either do research or to only do a limited amount of research before investing.” – Andrew Stotz Lesson 4: “If a person a listener was so inclined to invest in this type of a company where there is a binary outcome, either it's going to pass or it's going to fail. And as you said 7 out of 10 failed. The strategy to reduce the risk is to try to buy 10 of them, knowing that seven of them are going to fail but the three that path is going to fly.” – Alexander Burstein Resources: My Worst Investment Ever Book www.myworstinvestmentever.com Connect with Alexander Burstein: Linkedin Connect with Andrew Stotz: astotz.com Linkedin Facebook Instagram Twitter Youtube My Worst Investment Ever Podcast
My Worst Investment Ever Podcast
Aired 3 weeks ago 124:11
Is Metformin Really Dangerous, Little-Known Peptides For Muscle Gain & Fat Loss, Testosterone Replacement Therapy & Much More!
Is metformin really as dangerous as it's been made out to be? What are the best peptides to use for muscle gain, fat loss and cognition? How can you get started with testosterone optimization therapy? I answer all these questions and many more in this podcast with Jay Campbell, a Champion Men’s Physique Competitor and the best selling author of the Testosterone Optimization Bible and of The Definitive Testosterone Replacement Therapy Manual: How to Optimize Your Testosterone for Lifelong Health and Happiness... (along with a host of other books linked to in the resources section below). As a 17 year TRT patient, Jay is a master at manipulating and tweaking the human endocrine system to optimize performance and health. He has experience working with thousands of men and women in optimizing their nutrition, exercise, fitness and fat loss. Jay makes it his personal mission to affect positive and rapid change in each and every client who enters the mastermind program. During our absolutely epic discussion, you'll discover: -Jay's daily routine and why he eats only 3 days per week... Metformin Armour Desiccated Thyroid Lion's Mane Curcumin, turmeric, Protein powder, MCT oil Practice intermittent fasting if you're not fast-adapted or want to lose weight The cold-filtration whey isolate Jay recommends... 70% of people have some sort of response (allergic or otherwise) to whey protein True Nutrition Ben has used Mt. Capra Cold filtration similar to micro-filtration for wine Thorne Mediclear -Jay's response to Ben's concerns about the use of Metformin... Mitochondrial dysfunction 2 studies by Dr. Chandler Mars Morbidly obese diabetics using a disproportionate amount of Metformin "Life extension dose" varies due to body size, ancestry, etc. Jay has used Metformin for 17 years Lactic Acidosis: studies done on samples not representative of the population Gastric issues are a result of Metformin cleaning up microbiota Subsides as the biome becomes used to Metformin Metformin protects the brain and cleans vascular pathways -How to go about getting Metformin... Tell your doctor you want it because it's cardio-protective, prevents cancer and is believed to stop the progress of neuro-degenerative diseases such as Alzheimers It's also very affordable inhousepharmacy.vu -Whether Berberine should be used, and if so, as an alternative or a supplement to Metformin... Berberine is similar to Metformin, but isn't as regulated and is much more expensive Berberine doesn't have a good reputation among people in the know Metformin is the most studied drug in the world (because of diabetes) -Jay's favorite peptides and what to look for when choosing a peptide for yourself... Peptides are a great option for an aging man or woman to slow down aging process, increase sleep, etc. Ipamorelin (GHRP) Highest efficacy if combined with a growth hormone Best peptide for women by far Neanderthal genes Quercetin Tesamorelin FDA approved; created by Merck Created for HIV positive men for lipo dystrophy Extremely expensive Highly effective in eliminating body fat Peptide fact sheet from Tailor Made Compounding Sermorelin is useless PeptideSciences Semax as a nootropic BP 157 Jay doesn't like: Ibutamoren GHRP 2 or 6 -Why Jay is taking Armour Thyroid... Thyroid synergistic with hormones and testosterone Desiccated Thyroid: Combo of T3 and T4 -Rapid fire questions on testosterone... Is there a risk of cardio vascular health if one supplements their testosterone? If a man is a "metabolic emergency," potential for an incident; because of that person's compromised health Testosterone is cardio protective; beneficial for the heart for someone in good health TRT as a nootropic Testosterone increases dopamine signaling Feeling of "well-being" Improves working memory Once you start using it, do you have to be on it for life? Yes, but the individual's environment is vital What's the best delivery mechanism? Transscrotal application (absorbed 8x better in the scrotum skin) What are you taking with testosterone to mitigate the downstream side effects? World Link Medical You need testosterone to aromatize into estrogen to confer the protective effects to your biological system You'd never want to take an aromatase inhibitor What should you be looking for in reference ranges, and what should you be monitoring when you're on testosterone? -And much more! Resources from this episode: -Jay's recent roundtable on peptides -Jay's TRT Revolution podcast -Jay's book: "Guaranteed Shredded" -Men's Health Optimization Bundle -Ultimate Fat Loss Bundle -Jay's Facebook video about metformin -Cold filtered whey protein -Thorne Mediclear -Kion energy bar -True Nutrition whey protein -My article on the dangers of metformin -Jay's article on the benefits of metformin -Jay's Facebook video on metformin -Metformin Alters Microbiota, Improving Insulin Sensitivity -Metformin Alters Gut Microbiota of Healthy Mice: Implication for Its Potential Role in Gut Microbiota Homeostasis -Goat's Rue herb tea -Extended release metformin from Inhouse pharmacy -Berberine -Kion Lean -T.S. Wiley's book: Lights Out - Sleep, Sex & Survival -My podcast on testosterone optimization from A4M in Vegas -2020 A4M in Vegas -Ben's peptide article: How To Use Growth Hormone Stacks For A Better Body: Everything You Need To Know About IGF-LR3, GHRP, and GHRH Peptide Stacks. -Peptide fact sheet from Tailor Made Compounding -Ben's article "Should You Get Growth Hormone Injections (And Will GH or IGF-1 Increase Your Cancer Risk)?" -Thorne Quercetin -Dr. Seed's oral BPC-157 (use ode BEN for 15% off entire product line) -PeptideSciences -Semax -Testosterone for depression -Amazon version of the Testosterone Optimization Bible -Pharmacokinetics of testosterone cream applied to scrotal skin. -My podcast with Anthony Jay - Estrogeneration: How Estrogenics Are Making You Fat, Sick, and Infertile. -The DUTCH Hormone Panel -DirectLabs -Zach Bush's Restore Other notes from Jay: -Metformin Study: Mitochondrial Dysfunction -This was on a thoroughly compromised patient population group of Morbidly Obese Diabetics who were using anywhere from 6-9 grams of Metformin per day. If you do further searches, it’s actually the opposite. Metformin reverses Mitochondrial Dysfunction. There are many, many others. -Metformin Study: Lactic Acidosis - The fear of this condition happening was based on a study from the 40s (still attempting to find it) also in a massively compromised patient cohort. These patients were in end-stage renal failure and also obese and diabetic. We must be mindful that correlation does not equate to causation. All of these linked studies show that Lactic Acidosis rarely happens if ever in normal patients population groups. Check them here, here and here. Elevated plasma metformin concentrations (as occur in individuals with renal impairment) and a secondary event or condition that further disrupts lactate production or clearance (e.g., cirrhosis, sepsis, or hypoperfusion), are typically necessary to cause metformin-associated lactic acidosis (MALA). As these secondary events may be unpredictable and the mortality rate for MALA approaches 50%, metformin has been contraindicated in moderate and severe renal impairment since its FDA approval in patients with normal renal function or mild renal insufficiency to minimize the potential for toxic metformin levels and MALA. However, the reported incidence of lactic acidosis in clinical practice has proved to be very low (<10 cases per 100,000 patient-years).” Metformin Study: Gastric Issues (Nausea, Flatulence, Gut Discomfort etc) -This happens only to people who won’t clean up their shitty diet. Because Metformin is working directly on cleansing the microbiota. All of these studies show Metformin’s action on the Microbiota. Check the studies here, here and here. “Metformin, the most frequently administered medication to treat patients with type 2 diabetes, has only recently been suggested to alter gut microbiota composition through the increase in mucin-degrading Akkermansia muciniphila, as well as several SCFA-producing (short-chain fatty acid) microbiota. The gut microbiota of participants on metformin has exerted alterations in gut metabolomics with increased ability to produce butyrate and propionate, substances involved in glucose homeostasis. Thus, metformin appears to affect the microbiome, and an individual's metformin tolerance or intolerance may be influenced by their microbiome” Episode Sponsors: -Kion: The Clean Energy Bar is Kion’s satisfying, nutrient-dense, real-food energy bars with a delicious chocolate coconut flavor! Use discount code "bgf10" and get 10% off your order. -JOOVV: After using the Joovv for close to 2 years, it's the only light therapy device I'd ever recommend. Give it a try: you won't be disappointed. Use discount code "ben" at checkout and get a cool bonus gift with your order! -Thrive Market: Your Favorite Organic Foods and Products. Up to 50% Off. Delivered to Your Door. Order through my link and get 25% off your first order plus a free 30 day trial of Thrive Market's subscription program. -PSO-RITE: The PSO-RITE is your 24/7 massage therapist when your body needs it the most. Use discount code "ben10" to get a 10% discount off your order! Do you have questions, thoughts or feedback for Jay or me? Leave your comments below and one of us will reply!
Ben Greenfield Fitness