36 Burst results for "Melanoma"
WTOP
"melanoma" Discussed on WTOP
"Here today for a melanoma exam at kaiser permanente we believe the only way to care for all of you is by seeing all that is you kaiser permanente for all that is you learn more at kp .org kaiser foundation health plan at the main atlantic states incorporated 2101 east jefferson street rockville maryland three five two three thirty eight traffic and weather on the eights and back to dave in the traffic center it's bound to be a heavy wednesday commute already slow on the southeast southwest freeway 395 but southbound also on i -295 from suitland parkway down to the south side of the beltway on the interloop you're sluggish of out oxen hill but better once you hit alexandria with the work zone on the interloop clear outer loop off to a slow start from oldtown into oxen hill the police response beyond 210 where the local and through lanes merge along the far right side outbound suitland parkway heavy and slow through southeast getting in the uh maryland stopped because of in one the roadway beyond stanton road with only one lane getting by 50 of the bay bridge is fine though typical congestion on 270 95 in the baltimore washington parkway volume delays are building on the beltway in montgomery county and getting there on the inner loop out of fairfax county across the american legion bridge nothing blocking the way though harper's ferry the 340 detour continues between the shenandoah and harper's ferry road just like yesterday long volume delays at the overwhelmed traffic signal on route nine at harper's ferry road traffic is backed up all three ways now in virginia on 66 nothing to fear except traffic itself congestion eastbound near vieta and eastbound near bolston 95 northbound jammed through fredericksburg late to clear work zone beyond route three was tying up the left travel lane mckesson delivers medical supplies to government agencies through federal supply schedules visit mms dot mckesson dot com slash government for details that's mms dot mckesson dot com slash government dave dildine wtup traffic seven news first alert meteorologist mark pena well we had the heat wave last week and some heavy rain over the weekend and now we're seeing the slow transition towards a nice fall -like pattern weather and
WBBM Newsradio
Fresh update on "melanoma" discussed on WBBM Newsradio
"850. Chicago's Chicago's radio WBBM. only 1059 station dedicated to news around A the clock. Chicago man is News expected in Many court -year -old Vashon Tuesday Davenport for is arraignment accused of in aggravated a carjacking vehicular that happened hijacking nearly last a October year ago. on I -94 20 year before at Canal Port Avenue near Chinatown. Illinois State Police say the victim told them a man walked toward inside and his the SUV suspects holding got in and a fled the long area. firearm and motioning Police say a for witness him to recorded get out of the the carjacking vehicle. and posted He did it on social media. Authorities say that posting and a thorough investigation helped them identify Davenport an as the Australian suspect. professor Veron has Black News jabbed Radio 1059 himself with a WBBM. brain cancer vaccine all of the pathologists. in the name He's of the first research. person to receive Professor Richard a personalised Scalia is brain one of cancer Australia's vaccine leading after melanoma being diagnosed with an aggressive form of the tumour. Co -professor Georgina Long says researchers will take his journey after the jab. Eventually hopefully we may have more lead widespread to use more effective of vaccines personalised in vaccines cancer treatment Scott Recovery centres Mayman in for CBS Berwyn, News Austin, Canberra Cicero, Australia. Garfield Park FEMA and Pullman are about Disaster to observe new operating hours. Starting tomorrow most will be open from 8am until 5pm Monday Memphis All Park through Field Saturday. centres House will The will be closed have Saturday only on difference hours Sundays. is from 9 the .30am Austin At South until facility age 52 5pm. in your the Columbus business operating report internet is room will coming giving a let whole your new doctor meaning perform to miracles the term from house thousands call of operation miles
Dr. Jockers Functional Nutrition
A highlight from Stage 3 Cancer Healing Story Using Carrots & Coffee with Jaime Holmes
"This podcast is sponsored by my friends over at shopc60 .com. If you haven't heard of carbon 60 or otherwise called C60 before, it is a powerful Nobel Prize winning antioxidant that helps to optimize mitochondrial function, fights inflammation, and neutralizes toxic free radicals. I'm a huge fan of using C60 in conjunction with a healthy lifestyle to support your immune system, help your body detox, and increase energy and mental clarity. If you are over the age of 40 and you'd like to kick fatigue and brain fog to the curb this year, visit shopc60 .com and use the coupon code JOCKERS for 15 % off your first order and start taking back control over your health today. The products I use, I use their C60 in organic MCT coconut oil. They have it in various different flavors. They also have sugar free gummies that are made with allulose and monk fruit. They also have carbon 60 in organic avocado and extra virgin olive oil when it's combined with these fats, it absorbs more effectively. Carbon 60 is great as a natural energizing tool because it really helps your mitochondria optimize your energy production. Now if you take it late at night for some individuals, it may seem a little bit stimulating so that's why we recommend taking it earlier in the day and it will give you that great energy, that great mental clarity that you want all day long that will help reduce the and really help you thrive. So again guys, go to shopc60 .com, use the coupon code JOCKERS to save 15 % off your first order and start taking back control of your health today. Hey friends, welcome back to the podcast. I am always interested in remarkable healing stories and listening to people who have survived terminal cancer or some sort of late stage cancer and that's why I brought on my guest Jamie Holmes. We're going to talk about how she was diagnosed with stage 3B melanoma at the age of 33. This is back in 2012. She knew she was going to heal her body holistically with love and respect and how to treat her cancer as a symptom of a whole body in disarray and Jamie is actually a Canadian aerialist. She's a dancer, instructor, entertainment company and circus studio owner. She's performed all around the world, appeared in film and television. She's performed for awards, shows, concerts, music artists and more and during her healing process she dove right into the world of natural healing, wanted to learn as much as possible and today, 10 years post -diagnosis, she is still thriving but still passionate, motivated and curious about the wonderful capabilities of the body and optimizing health. You can check out her website jamiehomes .com and she's got a great book that we're going to talk about. It's called Carrots, Coffee and Cancer. Carrots, Coffee and Cancer. So without further ado, let's jump right into this interview and also if you guys have not left us a five -star review, now's the time to do it. When you leave us a review, it helps us reach more people and impact more lives with this message. Thanks so much for doing that and also share this podcast. This could really help inspire somebody that maybe is going through a tough time in their healing journey so be sure to do that and let's jump into this show. Well, Jamie, great to connect with you and you have a very inspiring story and so I'd love for you to share that with our audience.
WTOP
"melanoma" Discussed on WTOP
"Here year alone the deadliest form of skin cancer nearly eight thousand will die from it this morning consumer man herb weissbaum a contributing editor at checkbook .org reminds you a good sunscreen when used properly dramatically can reduce your risk of getting melanoma by at least fifty percent when you're sun you need to wear sunscreen regardless of your skin color even if you don't burn with enough sun exposure you could get skin cancer these are preventable skin cancers in many cases dr adam friedman is chair of the dermatology department at george washington school of medicine in washington dc and a spokesman for the american dermatology academy we of know the sun is the number one external driving force for skin cancer to get maximum the protection you want to choose a sunscreen with an s p f of thirty or higher one that is waterproof and provides broad spectrum coverage which means it protects you from both the sun's harmful rays uva and uvb put it on before you go outside and use a lot so we know that most people use roughly about a quarter what's of needed to achieve the spf number the uvb blocking number on the bottle so more is definitely better we say roughly a shot glass full of sunscreen for exposed areas which i realize is a lot of sunscreen so my advice is put on more reapply we typically say every two hours if you're outside for a long period of time or you're sweating you come out of the pool but the general mantra is more is better reapply when you can to achieve the best sun protective approach consumer reports test show that a good spray sunscreen when used properly can be just as protective as a lotion that said cr recommends parents choose lotion sunscreens for their kids and use sprays only as a last resort sprays can cause irritation lung inhaled so if you use a spray squirt some of it onto your hand and apply it to your child's skin keep in mind sunscreen is recommended for anyone six months and older so parents to keep need their babies younger than six months out of direct sunlight whether it be clothing blankets you if know your stroller has some type of protective cover the truth is physical protection is the best protection for everybody you know clothing is going to be more effective than any sunscreen if it's not paper thin and so translucent this rule certainly applies to babies a final point clearly any sunscreen is better than none but you want a product that you know will protect your skin consumer reports tested 55 sunscreens for its 2023 ratings the best lotions copper tone water babies spf 50 it had a perfect score of 100 points and everyday humans oh my bod spf 50 the two top -rated sun sprays were Trader Joe's SPF 50 plus and Neutrogena Beach and Defense Sun Protection Water SPF 50 consumer man Herb Weissbaum with checkbook .org read about the top rated sunscreens and how to use them properly a click away at our website search sunscreen among the top stories we're following on WTOP five people are in the hospital this morning locally three in critical condition Saturday this morning all of this after being shot while leaving a funeral in Bladensburg and after going cold for a decade an architect is charged this morning in three of the serial killings along Long Island New York's Gilgo Beach keep it up here and keep your dial right where it is we'll update you in just minutes on WTOP you're listening to 103 .5 FM and wtop .com Saturday morning July 15th at 148.
WTOP
"melanoma" Discussed on WTOP
"Who's here today for a melanoma exam. At Kaiser Permanente we believe the only way to care for all of you is by seeing all that is you. Kaiser Permanente for all that is you. Learn more at kp .org. Kaiser Foundation Health Plan of the Mid -Atlantic States Incorporated 2101 East Jefferson on 1238 WTOP we've got traffic and weather on 28th every 10 minutes Rita Kessler in the traffic center. Oh right now if you're in the district it is northbound 395 near Main Avenue just one left lane is getting by the crash and medical emergency delays coming from the Pentagon the westbound side is slow as well coming from the 11th Street Bridge all the way past the scene looks to be a rubbernecking delay inbound 50 and the Baltimore Washington Parkway are slow getting on to inbound New York Avenue near the Anacostia River the right side gets by the work now let's take a look at the trip to the Bridge Bay the problem right now on the bridge the eastbound span of the bridge the right lane of two is blocked with a broken down vehicle so that's one left lane getting across that span the westbound span is running two -way traffic so there are two lanes headed in the eastbound direction but because there aren't three that's why you have the delay on eastbound 50 on the River Severn Bridge solid headed across the Bay Bridge if you're on the westbound side of 50 with just two lanes getting across at the Bay Bridge your westbound delay is almost back to Cox Neck Road trying to make your way onto the westbound span of the bridge if you're on 95 in Maryland southbound near 175 the work was in the left lane causing the delay you'll also find in Virginia northbound 95 near Lorton Road that was a crash along the left side we have a lot of delays on 95 in both directions it's just gonna be a tough trip whether you're northbound or southbound because of the Friday getaway don't let bad teeth stop you from living your best life get a beautiful new smile in just 24 hours with g4 by gulpa visit yourteeth com to save $1 ,000 with this ad yourteeth .com I'm Rita Kessler WTOP traffic checking the 70s first alert forecast with Steve Rudin tracking showers and thunderstorms as we move through the remainder of the afternoon hours some may become strong to severe with gusty winds and heavier
The Dan Bongino Show
Calling All Dermatologists: Help Dan Bongino
"There's this thing On my index finger right I've got this vertical line in my nail It's this white line like really white It's not dark it's a white lines vertical not horizontal It's not one of those horizontal white lines you get They have a name I know what that is This is vertical because all the way down to the nail bed And it's been there for like three years or so I never thought anything of it I think I showed it to a doctor once and I remember him saying anything about it but I'm reading this story yesterday in New York Post And it's the craziest thing I see it on I think the truth or Twitter It's like woman goes to a manicurist there And saves her life and I'm like what is this about And I see a picture of the snail and it turns out the manicure is that these women had the same thing although the line was brown which is obviously different It turned out that she had some really serious melanoma growing underneath the nail bed and I'm like that's it I'm dead I am so dead I am dead And you know the first rule of the Dan bongino show is don't get that right So I don't want to get that So you know my Facebook page you know I leave it open for messages If you have any expertise in this you're a dermatologist and oncologist whatever gist you are What does that mean It is a white line in my index fingernail goes all the way down It's been there forever Never changes color It's not dark Am I going to die or something So I'm going to go to Facebook here and if you guys know what that is let me know because I don't want to violate the first rule of my show which is don't get that I've read that story The lady had to have parts of her finger removed I was like oh my gosh I can't go through another one I just got out of three surgeries I can't afford anymore Said the PT over my house yesterday Calcium First response Jacqueline rose Thank you Jack I mean calcium deposit is I don't know Is that what it is Are you guessing You could save my life your Jack Do you have any experience here in
AP News Radio
Higher cancer rates found in military pilots, ground crews
"A new study from The Pentagon finds that not only do military pilots have higher rates of cancer. So do ground crews that maintain the aircraft. A yearlong study of nearly 900,000 U.S. service members involved in aviation compared their rates of different cancers to others. And finds a 24% increase overall. When it comes to melanoma, the flight group had an 87% higher rate and thyroid cancer was 39% higher. The data has been long sought by retired military aviators who have been raising alarms for years, but were told that previous military studies found no higher rate of cancer than in the general population. The second phase of this study will isolate potential causes and look to identify carcinogens
Bloomberg Radio New York
"melanoma" Discussed on Bloomberg Radio New York
"And anywhere else you get your podcasts. Former president Jimmy Carter will begin receiving hospice care after a recent series of hospital stays as NBC's Monica Alba reports, the nation's 39th president has had other health concerns in the past. In his 80s, mister Carter was diagnosed with melanoma that spread to his liver and brain. Defying the odds with the help of an experimental drug, and threw it all, always keeping perspective on the fragility of life. The Carter center said in a statement on Saturday that he will no longer seek additional medical intervention with his family and medical team fully supportive of that decision, the 98 year old Carter occupied the Oval Office from 1977 to 1981. And vice president Kamala Harris is accusing Russia of committing war crimes in Ukraine. In a speech at the Munich security conference on Saturday, Harris said the U.S. has examined the evidence and there is no doubt these are crimes against humanity, and that's the very latest. I'm Jim Forbes. And now this Bloomberg sports update on the ice all three teams in action rangers 7 game winning streak is history. They fall three to two and overtime in Calgary Devils they win 5 to two in Pittsburgh and the islanders, they came up short in a big way losing 6 to two in Boston, they're the best team in the league college hoops in the big east St. John's. They lose the creighton 77 67 creighton's number 18. Rutgers a winner seaton hall comes up short. Hardwood in the pros, the all star weekend continuing from Salt Lake City, Utah, there were three events on tap for you on Saturday the skills competition that goes to team Utah comprised of walker Kessler Jordan Clarkson and Colin saxton all currently play for the hometown jazz. The three point shootout is Damian Lillard of Portland. He knocked off buddy heel of Indiana with the money ball. Lillard played his college basketball right down the road from Salt Lake at Weber state in the slam dunk champion, not a household name yet, he may be soon, Mac mcclung of the sixers, a newcomer put on quite a show. He had a reverse dunk over two people. He was Shaq's pick heading into it. The All-Star Game, of course, comes your way on Sunday, team LeBron versus team Giannis prior to the games, the league commissioner Adam silver spoke with the media. He drove home two points. First of all, priority number one is adding a new collective bargaining agreement. Number two, he doesn't feel that resting players is a problem. Some call it load management, some fans feel slighted as they pay good money to see top quality talents, he quoted scientific proof that stars need rest. And golf a man who's had plenty of rash starting to make a bit of a comeback. It's not a major, but it's still Tiger Woods, he carded a four under par 67 at the genesis invitational from Pacific palisades, California. That's his best round since 2017. He's tied for 26th, heading into Sunday start of the daytime for 58, so climbing the ladder should be wearing red on Sunday 23 of the game's best 25 players are there. With your Bloomberg sports update. I'm rob bushkin. This is a Bloomberg money minute. The number of millionaire renters is on the rise in high cost American cities. You can come up with all kinds of reasons why this is happening maybe at the wealthy couple who got divorced. Maybe this is the second property they own that they're renting. Creston caps wrote the story for Bloomberg news. Apartment developers are building these buildings with significant amenities that are attracted to people who want to live in a city, but either are prepared or are totally ready to die in most places. And while prices are starting to come down in some high cost cities, there's another challenge. So many of those sales are all cash purchases. So you're talking about affluent renders, maybe have the income, but they can't compete with someone who's coming in and just paying cash. The rental marketing software company rent cafe says affluent rattle households are now the fastest growing category of renters in the country. I'm Charlie palette, Bloomberg, radio. Bloomberg radio on demand and in your podcast team. On the latest edition of the tape podcast, a conversation with Omar Aguilar
The Dan Bongino Show
Dan Horowitz: The Dangers of mRNA Vaccines
"You know there was a study that was just published last week from the 13 Heart Association's publication circulation Harvard researchers they found in a group of kids that had myocarditis your 436 billion spikes floating in their blood plasma So that's the big part that we learned The mRNA goes forever potentially it goes all over your body and it's an unlimited amount It was a good idea to have your body maybe produce certain things But the dangerous thing is Moderna announced yesterday they want to do this with heart attack medication with melanoma cancer stuff but what we love is what we've learned is again it sounds like a body produced things that grow with a heart muscle or whatever but there's nothing that's good in the infinite quantities and this thing is a big problem and it's not even like we could say at COVID's over It's not just about COVID It's about we're in a new era of biomedical experimentation That they could just get away with putting stuff in billions of people's bodies when put on the face of this problem I mean you just have today It's all over the place that Taiwanese study in the European journal of pediatrics that 17% of the high school kids mainly boys in their survey 17% experienced at least some sort of cardiac side effect from the second dose of Pfizer meaning chest tightness chest pain irregular heartbeat maybe shortness of breath I mean hopefully not all 17% will have problems down the road but we don't know that
Bloomberg Radio New York
"melanoma" Discussed on Bloomberg Radio New York
"One of Moderna and Merck's recent collaborations has shown progress in a mid stage trial. The vaccine in combination with Merck's keytruda cut the risk of death a recurrence of the lethal skin cancer melanoma by 44%. And Moderna's CEO Staphon bhan cell spoke with Bloomberg's Paul Sweeney and Matt Miller about the breakthrough and how cancer treatment will continue to unfold in the coming years. So I think we're a few years away and not 5 or ten years a few years away. I mean basically what we have to do in 2023 based on this great data and we know it's real because nova P value is a very statistically significant is we're going to start a phase three melanoma in 2023. I guess it's going to take 12 to 18 months to enroll and then we need to wait 12 months to get 12 months of survival data and then find these super regulators. So that's a couple of years away. Now that the data is out, we're going to of course discussing with the FDA and over regulatory agencies to see is there a way to even accelerate that. So this is to be discussed with regulators. But that's for melanoma. The great thing is, of course, for all the families that have a high risk of melanoma, but the great news for me is I think this is kind of immunotherapy 2.0 because what we saw with checkpoint in our kitchen dry and all those medicines is a huge ability to impact your immune system to kind of wake up your immune system to go eat your cancer. But what we've shown for the first time in the history of medicine is our ability to design a product for one human being at a time where we could in our medicine the mutation of your specific cancer and we've shown this morning given the huge difference of recurrence and death versus get you to have a gold standard. We show that we can teach your T cells, which is part of the immune system to recognize you cancer and then go eat it. And so I'm very excited about it, processes Moderna technology, 2019. We made a lot of progress in them. So do I believe we can do better? I do. You know, it took us 45 days on average to get the drugs to patients from a biopsy. Right. I think the line of sight to 30 days that will save more lives and I want to keep pushing the team to even go faster so that we can help as many people as we can across many cancer types. So I mean, this seems promising, not just in fighting melanoma and fighting skin cancer, but in fighting other cancers as well. Exactly. So I think every solid tumor cancer is fair game now, does he mean it's going to work everywhere? We will have to do the clinical studies. But the good news given the safety profile of a product was very good. The safety profile of a combination. More than a plus milk K two drug look very similar to KT dry alone. As you know, sometime with combination, you see worst toxicity. And so we're not really viable for patients. And so what's very exciting now is given we are very strong data in a lot of people our goal is to run several phase three at the same time in melanoma obviously, but we're working with colleagues at Merck to prioritize which over tumors do we start in, as you know, is used in lung cancer in breast cancer, in renal cancer, many of our cancers. And so we're going to try those first. I also want to explore what can we do to people that are metastasis in the cancer. I also want to explore in our personalized cancer vaccine Moderna alone. You know, the great news is we have now $17 billion cash. And so we want to invest that capital to make new medicine and this is a great place to invest because there's a big medical need for cancer. Stefan talked us about the size of this market. How do you think about the opportunity for this particular therapeutic? So I think it's a very big, just one comparator is catching ourselves, which is on a run rate of $16 billion per year. And analysts predict up to 30 billion by 2028 when KT dry expires. And so when you get wet catch you drag it, let's go back a bit in history. During its phase three kilogram of 40% reduction, versus standard of care then in terms of recurrence and death on the same metrics we showed your 44% decrease because you schedule the new gold standard. And so do I believe the opportunity of Moderna PCV down the road as we expand to more cancer types as we expand to metastatic stage as we expand to earlier cancer could be as big or even bigger and get you draw. I do think so. So I think it's a very large opportunity. Stefan, how was the approval process evolved over the last several years since the pandemic? When you interact with the FDA and you've done it for obviously for many, many years. Has it changed? Has it become perhaps easier, more streamlined? How are you finding it? So I think the FDA first has done an amazing job during the pandemic that we all benefited from. I think the FDA has a much better understanding of modern platform. And I think the FDA now understand that this is a platform. In the early days, if you want to add, of course, to prove to the regulator, which both of you and everybody wishes that are regulators do to protect all of us, to get the clinical data to help us understand what is similar between each drug of Moderna. The great news about this product for cancer that we announced this morning is it's 100% the same chemical matter for making the mRNA the COVID-19 vaccine. It's the same chemical in the same manufacturing process so think about the comfort in terms of safety of a product that this provides regulator and us. So I think the FDA has
Bloomberg Radio New York
"melanoma" Discussed on Bloomberg Radio New York
"I'm Ed Baxter, one of Moderna and Merck's recent collaborations has shown progress in a mid stage trial. The vaccine in combination with Merck's keytruda cut the risk of death a recurrence of the lethal skin cancer melanoma by 44%. And Moderna's CEO Stephane bund cell spoke with Bloomberg's Paul Sweeney and Matt Miller about the breakthrough and how cancer treatment will continue to unfold in the coming years. So I think we're a few years away and not 5 or ten years a few years away. I mean basically what we have to do in 2023 based on this great data and we know it's real because you know the P value is a very statistically significant is we're going to start a phase three melanoma in 2023. I guess it's going to take 12 to 18 months to enroll and then we need to wait 12 months to get 12 months of survival data and then file these super regulators. So that's a couple of years away. Now that the data is out, we're going to of course discussing with the FDA and other regulatory agencies to see is there a way to even accelerate that. So this is to be discussed with regulators. But that's for melanoma. The great thing is, of course, for all the families that have a high risk of melanoma, but the great news for me is I think this is kind of immunotherapy 2.0 because what we saw with checkpoint in KT dry and all those medicines is a huge ability to impact your immune system to kind of wake up your immune system to go eat your cancer. But what we've shown for the first time in the history of medicine is our ability to design a product for one human being at a time where we could in our medicine the mutation of your specific cancer and we've shown this morning given the huge difference of recurrence and death versus sketchy rubber gold standard. We show that we can teach your T cells, which is part of the immune system to recognize your cancer and then go eat it. And so I'm very excited about it, plus this is Moderna technology. 2019, we made a lot of progress in vents. So do I believe we can do better? I do. You know, it took us 45 days on average to get the drugs to patients from a biopsy. I think the line of sight to 30 days that we saved more lives. And I want to keep pushing the team to even go faster so that we can help as many people as we can across many cancer types. So Steven, I mean, this seems promising, not just in fighting melanoma and fighting skin cancer, but in fighting other cancers as well. Exactly. So I think every solid tumor cancer is fair game now, does it mean it's going to work everywhere? We will have to do the clinical studies. But the good news given the safety profile of a product was very good. The safety profile of a combination. More than a plus more K two draw look very similar to KT drive alone. As you know, sometime with combination, you see worst toxicity. And so we're not really viable for patients. And so what's very exciting now is given we are very strong data in a lot of people our goal is to run several phase three at the same time in melanoma obviously, but we are working with colleagues at Merck to prioritize which over two modes we start in, as you know, kitty gray is used in lung cancer in breast cancer, in renal cancer, many of our cancers. And so we're going to try those first. I also want to explore what can we do to people that are metastasis in the cancer. I also want to explore in our personalized cancer vaccine Moderna alone. The great news is we have now 17 billion of cash. And so we want to invest that capital to make new medicine and this is a great place to invest because there's a big medical need for cancer. Stefan talked to us about the size of this market. How do you think about the opportunity for this particular therapeutic? So I think it's a very big, just one comparator is getting ourselves, which is on a run rate of $16 billion per year. And analysts predict up to 30 billion by 2028 when KT dry expires. And so when you look at what kitchen drive did, let's go back a bit in history. During its phase three kilogram of 40% reduction, versus standard of KL then in terms of recurrence and death. On the same metrics, we showed you 44% decrease because you schedule the new gold standard. And so do I believe the opportunity of Moderna PCV down the road as we expand to more cancer types as we expand to metastatic stage as we expand to earlier cancer could be as big or even bigger and get you draw. I do think so. So I think it's a very large opportunity. Stefan, how was the approval process evolved over the last several years since the pandemic? When you interact with the FDA and you've done it for obviously for many, many years, has it changed, has it become perhaps easier, more streamlined, how are you finding it? So I think the FDA first has done an amazing job during the pandemic that we all benefited from. I think the FDA has a much better understanding of modern platform. And I think the FDA now understand that this is a platform. In the early days, if you want to add, of course, to prove to the regulator, which both of you and everybody wishes that all regulators do to protect all of us, to get the clinical data to help us understand what is similar between each drugs of Moderna. The great news about this product for cancer that we announced this morning is it's 100% the same chemical matter for
Bloomberg Radio New York
"melanoma" Discussed on Bloomberg Radio New York
"And Merckx recent collaborations has shown progress in a mid stage trial. The vaccine in combination with Merck's keytruda cut the risk of death a recurrence of the lethal skin cancer melanoma by 44%. I'm Moderna's CEO Stephane bonsell, spoke with Bloomberg's Paul Sweeney and Matt Miller about the breakthrough and how cancer treatment will continue to unfold in the coming years. So I think we're a few years away and not 5 or ten years a few years away. I mean, basically what we have to do in 2023 based on this great data and we know it's real because you know the P value is a very statistically significant is we're going to start a phase three melanoma in 2023. I guess it's going to take 12 to 18 months to enroll and then we need to wait 12 months to get 12 months of survival data and then find these super regulators. So that's a couple of years away. Now that the data is out, we're going to discuss it with the FDA and over regulatory agencies to see is there a way to even accelerate that. So this is to be discussed with regulators. But that's for melanoma. The great thing is, of course, for all the families that have a high risk of melanoma, but the great news for me is I think this is kind of immunotherapy 2.0 because what we saw with checkpoint in KT dry and all those medicines is a huge ability to impact your immune system to kind of wake up your immune system to go eat your cancer. But what we've shown for the first time in the history of medicine is our ability to design a product for one human being at a time where we could in our medicine the mutation of your specific cancer and we've shown this morning given the huge difference of recurrence and death versus sketchy driver gold standard. We show that we can teach your T cells, which is part of the immune system to recognize that you cancer and then go eat it. And so I'm very excited about it, processes modern technology, 2019. We made a lot of progress in advance. So do I believe we can do better? I do. You know, it took us 45 days on average to get the drugs to patients from a biopsy. Right. I think the line of sight to 30 days that we saved more lives and I want to keep pushing the team to even go faster so that we can help as many people as we can across many cancer types. So Steven, I mean, this seems promising, not just in fighting melanoma and fighting skin cancer, but in fighting other cancers as well. Exactly. So I think every solid tumor cancer is fair game now because he mean is going to work everywhere. We will have to do the clinical studies. But the good news given the safety profile of a product was very good. The safety profile of a combination. More than a plus Merkel look very similar to case you draw along. As you know, sometime with combination, you see worst toxicity. And so we're not really viable for patients. And so what's very exciting now is given we are very strong data in a lot of people our goal is to run several phase three at the same time in melanoma, obviously. But we're working with a colleague at Merck to prioritize which over tumors do we start in, as you know, kitty ray is using lung cancer in breast cancer, in renal cancer, many of our cancer. And so we're going to try those first. I also want to explore what can we do to people that are metastasis in the cancer. I also want to explore in our personalized cancer vaccine Moderna alone. You have a great news is we have now a $17 billion of cash. And so we want to invest that capital to make new medicine and this is a great place to invest because there's a big medical need for cancer. Stefan talked to us about the size of this market. How do you think about the opportunity for this particular therapeutic? So I think it's a very big, just one comparator is catch you ourselves, which is on a run rate of $16 billion per year. And analysts predict up to 30 billion by 2028 when KT drive expires. And so when you drag it, let's go back a bit in history. During its phase three kilogram of 40% reduction, we assume standard of KL then in terms of recurrence and death. On the same metrics, we showed you 44% decrease because you get the new gold standard. And so do I believe the opportunity of Moderna PCV down the road as we expand to more cancer types as we expand to metastatic stage as we expand to earlier cancer could be as big or even bigger in case you draw. I do think so. So I think it's a very large opportunity. Stefan, how was the approval process evolved over the last several years since the pandemic? When you interact with the FDA and you've done it for obviously for many, many years. Has it changed? It has to become perhaps easier, more streamlined, how are you finding it? So I think the FDA first has done an amazing job during the pandemic that we all benefited from. I think the FDA has a much better understanding of modern platform. And I think the FDA now understand that this is a platform. In the early days, if you want to add, of course, to prove to the regulator, which both of you and everybody wishes that all regulators do to protect all of us to get the clinical data to help us understand what is similar between each drugs of Moderna. The great news about this product for cancer that we announced this morning is it's 100% the same chemical matter for making the mRNA when spiders, the COVID-19
Bloomberg Radio New York
"melanoma" Discussed on Bloomberg Radio New York
"To help stop people dying from melanoma from cancer skin cancer? Sure. So I think we're a few years away and not 5 or ten years a few years away. I mean, basically what we have to do in 2023 based on this great data and we know it's real because of a P value is very statistically significant is we're going to start a phase three melanoma in 2023. I guess it's going to take 12 to 18 months to enroll and then we need to wait 12 months to get 12 months of survival data and then find these super regulators. So that's a couple of years away. Now that the data is out, we're going to of course discuss it with the FDA and over regulatory agencies to see is there a way to even accelerate that. So this is to be discussed with regulators, but that's for melanoma. The great thing about today is, of course, for all the families that have a high risk of melanoma. The great news for me today is I think this is kind of immunotherapy 2.0 because what we saw with checkpoints in our kitchen dry and all those medicines are usually ability to impact your immune system to kind of wake up your im system to go eat your cancer. But what we've shown this morning for the first time in history of medicine is our ability to design a product for one human being at a time where we could in our medicine the mutation of your specific cancer and we've shown this morning we can teach your T cells, which is part of the immune system, processes modern technology, 2019, we made a lot of progress in advance. So do I believe we can do better? I
Bloomberg Radio New York
"melanoma" Discussed on Bloomberg Radio New York
"Of fraud bail denied extradition hearing in February, U.S. prosecutor in the case says it's one of the largest frauds ever inflicted on the public in the United States. Current CEO John ray in Congress today said it will take some time to see how much money can be recovered. Congress looks at potential oversight. Scientists have managed a first time to use producer nuclear fusion results using less energy to produce than it generates a major energy advancement. Australian authorities say 6 people, including two police officers were killed and an hours long gunfight at a rural property in Queensland. Moderna and Merck are announcing mid stage trials of an mRNA vaccine that reduce deaths from melanoma. Skin cancer, final stage studies next year and Senate Republican leader Mitch McConnell has blamed GOP midterm Senate losses directly on Donald Trump and some of his candidates that he hand picked Trump. McConnell said, look at Arizona, New Hampshire, and Georgia. In San Francisco, I met Baxter. This is Bloomberg back to Hong Kong rich. All right, and getting back to that FTX and back when fruits arrest in The Bahamas, let's have a look at what it means for the whole crypto space if you will, Mike mcglone is Bloomberg intelligence, senior commodities strategist. Mike, thank you so much for joining us. Contagion, that's short term, but what are we seeing with 8 regards to that and does it have in some ways some knock on effects which are a little bit more permanent? Yes, well you got it right now, the biggest fear is contagion. There's been massive outflows and exchanges like binance people just removing their coins because they're afraid they're going to lose them. But they're not selling them. That's been a significant thing with Bitcoin initially dropped around 15,000 on the news. And now it's up around 17 18,000. You look at things like Ethereum too, it dropped to around a thousand and now it's 1300. So the market's hanging in there, despite the shocking news. And I think what it's doing is, you know, the quote I like to use when I did my outlook for this month is that code committed no crime. So I think we're going to see out of this in the longer term is some pretty significant regulation and one thing that this episode does show us is it needs regulation. Okay, so we are going to get some. What do you think it's going to look like if you had to guess? I mean, you're talking to people in the industry. I'm curious about what the industry would support in an environment like this. Well, Doug, I think it's one of those things the libertarian realized that that's kind of a pipe dream to all those libertarians. You need some of the protect investors because there's a lot of nefarious actors that. And that's for me from someone from the futures background. I'm just used to 20 to one leverage and people firms going down there for doing similar things that FTX did. Unfortunately, it's normal, but that's just what happens, but you don't believe that read. You don't hear about all the good things that are happening in space. So I think what's going to happen is it's going to what my colleague Nathan dean pointed out, who's been in there in Washington in the heart is going to stall for a while because we have to go through the hearings and stuff. But things will probably accelerate is the focus on stablecoins. I like to call them crypto dollars, but that's the most widely traded space in this space and who better to regulate than the U.S., the fact that our dollars is the most widely traded crypto. So I think what's going to happen is it's going to bring in layers of compliance and things that's going to cost a lot more money. But make it more legitimate for entities to be able to transact dollars via tokens instantly 24/7 and met the technology move forward. And that's the key thing to think about here is STX was a bad actor and some of the other ones are failing, but the technology, what they're representing things like Bitcoin and stereo encrypted dollars is revolutionary and it's just going to advance. About blockchain and chiefly is one of the big things, isn't it? Will this then presage, do you think you might, you know, we've got thousands of cryptos? Will we have a massive shake out? They can't be room for all of them. So true, Richard, actually, there's 22,000 cryptos lifted in coin market cap dot com. And I remember writing about this when it went above 10,000 for the first time in saying, this is just silly massive speculation machine. So that is getting flushed. A lot of that needed to be flushed. Sorry, this is just speculation. But out of those 22,000, there is 12 that in the Bloomberg galaxy crypto index, which are legitimately probably going to matter and probably the top hundred, are really going to make a difference in the world. But of the top 5, three of the top 5 are dollarized tokens, dollar token. So it's the buck was really taking over this layer. Well, so people trade a lot, but that's one key thing to remember. I mean, it's a perfect segue to the next question, Mike. Does this necessarily put pressure on the U.S. government to come up with its own crypto? Actually, I think it's the opposite, Doug, because it's happening organically. What it does push the pressure on is U.S. government to regulate the space like they do banks and primary dealers, both by work debt. So you can regulate these $50 and get past some of these privacy issues that countries like China want in their CBC D.C., which is essential main digital currency. So I can control everything and watch everything people do. But in this country, we have privacy laws, the thing is the market's gone organically to the digital dollar tokenized dollars, which is the U.S. government needs to regulate. If anything, this is an example that, okay, it needs regulation. We got accelerate it. Now, and also what it's one of those things we should not mess this up because the space has gone for the dollar organically and it could have gone to the year over the year that
Bloomberg Radio New York
"melanoma" Discussed on Bloomberg Radio New York
"Trimmed down their earnings estimates. That's going to start happening once companies renounce. I look like there was going to be a little euphoria here in the market today. When we got the opening bells, the S&P 500 actually opening above some of its key resistance points and right at that 200 day moving average. Today, right now it's going to close just a smidge below that 200 day. It's higher on the day by about 29 points or 7 tenths of a percent, the Dow up by about three tenths. The NASDAQ composite higher by about 1% on the day and Carol the Russell 2000 moving higher by about 8 tenths to close out the day. All right, and definitely well off our best levels of the day when it comes to those equity averages. But what's interesting is, if you take a peek into the S&P 500, most names in the index actually posted some gains, 357 to be exact, a 146 lower scarlet. So there was a bit of a more risk on trade today, despite finishing off our highs. Yeah, it was more of a broader advance that was a broader decline in line with the S&P 500 closing up shy of 1% up three quarters of 1%. In terms of gainers, you have media entertainment, the likes of Netflix, for instance, leading the way REITs have been positive for most of the day and energy. The best performers of the year holding on to 1.9% advance. On the downside, autos continue to be a drag, particularly Tesla, which is lost ground for the 6th time in 7 days, Carol. Yeah, it's pretty tremendous what has happened with that name and you do wonder we were having conversations on air earlier about what investors they've already been upset about what's happened with the share price. And what happens in terms of going forward for that company, Elon's been a bit busy as we all know. All right, so let's get to some of the individual gainers, Moderna. Certainly standing out top of the NASDAQ 100 top in the S&P 500, up just shy of 20% by the close today. We know what happened. Mid stage clinical study of its experimental personalized cancer vaccine for skin cancer melanoma in combination with a drug over at Merck it reduced the risk of relapse or death from melanoma. I know the CEO was on our air talking earlier. I mean, this stock just really popping in a big way and just driving some optimism that it's just not about the COVID vaccine, right? That there's more in the pipeline. Yeah, and that's a big deal. I mean, because when we talk about the mRNA and just how instrumental that was to developing the COVID vaccines, everyone Carol said, what else can we use this for? And this at least a glimmer of hope that maybe there is a broader use for this. Yeah, absolutely. All right, so as I said, top there, meta, I'm just find it interesting. It's up another 4.7% continuing its bounce back. It's up roughly 37% in the past 5 trading days, much of it, I'm sorry, meta. I'm sorry, I meant to talk about it. Well, you were talking about that. Let's talk about meta. It's up 4.7%. It was top of the NASDAQ 100 earlier. It's up about 30% since November 3rd, still down more than 60% so far. The only news of import perhaps meta's Instagram testing a new feature called candid stories. It's also rolling out a notes feature on Instagram. So maybe just trying to go after some of those more popular apps to maybe. That's what, like, a 140 characters where you short. Double it to 280 in a few years. And go to 4000, at three Elon Musk buys it. Just pick up a book, read a book, everybody. Take a walk in nature. That's what I'm going to say. DocuSign, that's the one continuing its bounce back. It is up more than 37% in the past 5 days, much of it coming after that latest quarterly beaten upbeat forecast yesterday, city raising its price target to 72 from 59, up more than 7% in today's session, and it is still down more than 62% year to date. But nonetheless, investors have been moving into it as of late, all right, Tim over to you. All right, let's get to the biggest decliners in the S&P 500 on a point basis today. It goes once again to Tesla, shares falling more than 4%. Scarlet you mentioned down 6 of the last 7 days that held true at the close. The company closed just above $500 billion in market cap, though it did dip below it a little earlier in this session. It last checked $508 billion as the market cap. Now, still though, hit a 52 week low today, actually closing at its lowest level since November of 2020. We are starting to hear from more and more investors who are upset with the decline that we've seen in Tesla most notably. I think today is Ross Gerber over at Gerber Kawasaki, tweeting at the board of directors saying that the company needs to be an interim CEO and the board of directors needs to quote wake up according to Roscoe. The board. Have you looked at the board? I have. There's some other folks with the last name Musk on the board. Yeah, that's a good point. You make a good point. There is no point. Just a statement. The facts. Okay. Let's talk airlines. United Airlines finishing the down by close to 7%. We actually saw a host of airlines move lower today. We saw American falling after it said that Derek Kerr, the company's CFO is going to step aside. We saw JetBlue falling after it said that demanded the final weeks of the year is looking worse than accepted. United though, falling after that huge order for 107 87 dreamliners from Boeing, this is a multi-billion dollar deal. Sheila khayal over at Jefferies, we've spoken to her in the past. She said that although the order was needed elevated leverage is a substantial headwind for the company going forward. And then coinbase finishing it down by a little more than 9%, got to look at crypto related stocks today after hearing from John J ray the third testifying in front of the house. All right. And we also got a look at what happened, of course, in the debt markets. I think Carol alluded to it. At one point on the day, a 24 basis point drop on the two year as well as on the 5 years, some of those big deal, right? The shorter end moving in. It is a huge deal here. And now on the official clothes here basically down 14 basis points on the two and about ten on the ten year yield. And what I thought two things I thought were interesting about this, Carol too. Was just how severe the move was and a lot of people now sort of questioning whether the big bond market sump, whether that's over, whether all this buying is going to continue. But just to get to scarlet, who I learned today is like a tinfoil hat conspiracy theorist. There was a lot of activity. There was a ton of activity right before 8 30 and we saw it in the bond market here and a lot of people are wondering why. The White House again, I'm going to go back to what they said. They said they're not aware of any leaks of the CPI data. Okay. So let's just make that clear. Would it be aluminum? I don't have a problem. It happens, but it doesn't happen often, right? And data needs to be protected before it gets out into the market. Okay, well, let's think about what happens tomorrow in the way that fed chair J Powell takes in data like this. The inflation is certainly moving in the right direction, but as we've been talking about throughout
Bloomberg Radio New York
"melanoma" Discussed on Bloomberg Radio New York
"Cancer drug. How far away do you think we are from an actual on the market medicine to help stop people dying from melanoma from cancer skin cancer? Sure. So I think we're a few years away and not 5 or ten years a few years away. I mean basically what we have to do in 2023 based on this great data and we know it's real because you know the P value is very statistically significant is we're going to start a phase three melanoma in 2023. I guess it's going to take 12 to 18 months to enroll and then we need to wait 12 months to get 12 months of survival data and then find these super regulators. So that's a couple of years away. Now that the data is out, we're going to of course discussing with the FDA and other regulatory agencies to see Israel weight with an accelerate that. So this is to be discussed with regulators. But that's for melanoma. The great thing about today is, of course, for all the families that have a high risk of melanoma. The great news for me today is I think this is kind of immunotherapy 2.0 because what we saw with checkpoint in our kitchen dry and all those medicines. A huge ability to impact your immune system to kind of wake up your immune system to go eat your cancer. But what we've shown this morning for the first time in history of medicine is our ability to design a product for one human being at a time where we could in our medicine the mutation of your specific cancer and we've shown this morning we can teach your T cells, which is part of your immune system, processes modern technology, 2019. We made a lot of progress in events. So do I believe we can do better? I do
How to Live A Fantastic Life
"melanoma" Discussed on How to Live A Fantastic Life
"And we're talking about some of the most horrific relaunches, some of the most touching heartfelt. I mean loss of limbs, people dying and being zipped up in a body bag and coming back. And every single person that I've ever talked to, I have not had one person say, you know what? I would absolutely go back and change the outcome, not one, because, you know, there's also that awesome that awesome phrase, what doesn't kill us makes us stronger, right? And that's really what it's all about, a relaunch is something that, as I said, professionally personally, we all are going through it right now. And it's the collective relaunch. It's a world global relaunch. And we don't have to feel isolated and alone anymore because it is happening on such a massive state. I mean, we're talking about people truly waking up and realizing that where they were in the past. It's not holding you back anymore. You have the opportunity to change things and you can literally start right now and it doesn't have to be debilitating. It doesn't have to be like, oh my gosh, this is going to be so massively gigantic for me. It doesn't have to be. It's these small, incremental steps. It's like, you know, when you're learning how to get involved in any type of athletic program, you don't just go out and run that, run that marathon, you start, and you're like, all right, hey, today let's just put our shoes on. And then let's see where it goes tomorrow. And I think that's what a very successful relaunch really means. I think that's true and I think relaunching is very important. And I think it's very important to keep it all in perspective. I mean, you had a very significant health issue in having a melanoma. I and my former life was a dermatologist. So I know the significance of the melanoma aspect, and it can be, if you don't catch it early enough, it can be very devastating. My father died from a melanoma, and so that's how devastating it can be unfortunately. Absolutely. And it can take over and I was lucky. My mom wasn't quite as lucky as I was. Yeah, so that's the problem. And that's the disease of us fair skinned people, unfortunately, were subject to it because, unfortunately, the sun is good, and it's bad. So we got to learn to live with it appropriately. And, you know, when we're children, unfortunately, we did not always live with it appropriately. Got some burns. That's what comes back to haunt us in later years.
The Kevin Bass Show
"melanoma" Discussed on The Kevin Bass Show
"If it hadn't been detected dealt with these quasi melanoma as it were. It would have the immune system would have shut them down. They wouldn't have escalated and become true melanoma. Dangerous melanoma. Here's a paper. By Gilbert Welch, he was a professor at Dartmouth, Benjamin mazer and at Adamson. Called the rapid rise in cutaneous melanoma diagnoses. As we can see from figure one, the incidence of cutaneous melanoma is rapidly rising, whereas non cutaneous melanoma is staying roughly the same. Suggesting that something about cutaneous melanoma is different than non cutaneous melanoma. It's easier to detect non cutaneous melanoma that not cutaneous melanoma continues polynomial melanoma in the eyes, for example. It's easier to detect non cutaneous malnourished screen for it, the implication is, therefore, that's why we're seeing more of it. Let's look at another figure. Here, let's look at the relationship between melanoma incidents and mortality, figure four B here you can see that incidence of melanoma is going up but mortality is staying the same except for around 2015, 2016, 2017. We're seeing a drop in mortality around that time. That's related to immunotherapy, immunotherapy works to new cancer therapy. But if incidence is going up, we would also expect for melanoma itself the mortality to also go up. But it's not incidents of melanoma is going up dramatically, but mortality is staying the same. And interestingly, it's the same way with many cancers. Not just melanoma, we're detecting many cancers at much higher incidence. Because of more sensitive screening, despite very similar mortality over time. Now here we can see in figure three a, the increasing use of skin biopsies. We've had almost a doubling. Of skin biopsies from 2004 to 2017 among Medicare beneficiaries. Almost a doubling correspondingly, we've had almost a doubling of melanoma, diagnoses. Likewise, the pathological thresholds.
The Kevin Bass Show
"melanoma" Discussed on The Kevin Bass Show
"A kind of resistance against elite, centralized modern power, but this movement takes the form mainly of pseudoscience. So instead of voicing these concerns directly, these new foods represent things that were alienated from, instead, people invent pseudoscience to explain why they don't like these foods. In this video, I'm going to address some of that pseudoscience. In particular, with respect to seed oils and melanoma, skin cancer. And.
Double Toasted
"melanoma" Discussed on Double Toasted
"Not kidding. No no no i. It's kim please. i'm okay that's all that's last arrest. Let's let's talk about okay zombie. She israeli people listen. I'm biased alright. Because until you marvel zombies you put that shit. Together i look. You can't go there and take my house take my heart. Take my wife yeah. I'm like not mentally wired to say. I don't like this all right that's gonna take. It would take a lot to do that and for me. Melanoma won't be won't be fair man. I'm going to be fair with this. If they didn't do the job with this. I would admit it. But i love this episode man because as a fan of zombie movies in zombie. Movies have become a genre within themselves. Now you got you got trope that you're going to hit now if you're sticking to the genre format and this episode it does that many hits the every everyone of them. Every zombie trove trope. That's out there with the with the fresh spin of that. What if zombies had superpowers. What did they had not not not like. Being big and spitting fires only know what they had capes and lasers sure an eight people. And that's what this what this does and it's made more fun that those superheroes are these superheroes that we know in love in the marvel universe. Play damn god was too late. Jeez come big time to go green. No hear me and come out come. What do you mean no. You are about to die at the hands of the children was. Zombies manages complete. Ask like zombie shambling. Each he's he doesn't three stooges game he didn't do was like do.
KFI AM 640
"melanoma" Discussed on KFI AM 640
"You're listening to the Daily Dive weekend edition. Africa would Republican governor was that said it when they were trying to start taking away these unemployment benefits. And they said, Hey, if you can go out to dinner, you can start going back to work. And it kind of rings. True. In a sense, you know, a lot of people still say, Hey, people are worried about getting Covid 19 Child care is a huge issue with returning to work, but Some people are content getting these benefits and and, you know, don't really want to go back to that old job that they might have had. So they're looking for something new and a lot of different places. You also focused on a minus hospitality. There's ST Louis based hotel company. They have 44 locations, and they kind of went through this whole thing where they were doing job fairs. Nobody was showing up and little by little as these unemployment benefits started going away, then they started seeing people come back. Tell us about that. Lot of businesses in the hospitality space, you know, they saw, you know decline in their workforce. Today, the furlough. People lay people off and now they're looking to bring people back. And that's a challenge right and you to bring people back on the line because Yes, some people on unemployment benefits, but also, some people have gotten out of the business altogether. Right? There's a lot of job opportunities in other sectors, including places like construction in anything related to e commerce and warehousing, and those jobs usually pay better than a hotel or restaurant jobs. So in some cases, people left the industry even if they're still out there working and, you know, we know that people are our guests that that may be true that if you're willing to go out to eat, maybe you could should be willing to take a job. But you know, that's not really real. The right If you go to a restaurant, you say, Oh, man, This doesn't look like a safe place for my family to eat. I don't like how many people are close by me. You can walk out. If that's your place of employment. It's a little bit harder to quit. Right. So there's people that are taking their time people maybe even waiting until a lot of people are pointing till September, right? Not only will benefits roll off schools, you know. Hopefully most the country could be reopened, and that allows people maybe to go back to work. So there's a number of factors that play for sure, And the competition is high for those same pool of employees. You mentioned manufacturing company You know, they're just noticing it with big signs on other people's businesses saying, Hey, big pay big benefits Come over here and and for a lot of manufacturing companies. That applicant pool is, you know similar profiles, so the same people that they're shooting for Right. I mean, we've heard and seen studies showing that people have readjusted their perspective of during the pandemic, and part of it is just a chance to re evaluate and part of it. Is these benefits that you know a lot of people. I talked to really view sort of the minimum wage. Now it's $15 an hour, even though in states like Missouri and elsewhere. It's much less than that officially, but they sort of say if I'm not getting 15 an hour I'm gonna keep looking, because I know there's a lot of opportunities out there right now. How long do we expect this trend to last? Because, you know, one of the other things I mentioned also was, you know a lot of people quitting their jobs, not wanting to go back to what they had before looking for those other opportunities. How long are we going to expect this to last? I mean these unemployment benefits as you mentioned in a lot of areas. Will fully expire in September. Is that the time we're going to see everybody kind of say Okay, now I need to go start looking for a job in it. I think we're right now this summer kind of at the peak point of a post pandemic labor shortage, and I think things will ease a bit as we get into the fall and people adjust a new routines, and there's maybe not some of these disincentives, but I still think the ball is going to be in the workers Court. You know, we saw this 2019 remember the labor market was really tight, and I think it's getting back to that point. Very quickly, and that's going to mean that employers are maybe need to raise wages, or maybe need to adjust and say, you know, could this job be done remotely, or could I be more flexible on my hours in order to attract the workers they need Eric Morath, Labor and Economics reporter at the Wall Street Journal. Thank you very much for joining us. Sure, Happy to join you, Mhm. Finally, for this week, some hopeful news on the treatment of cancer. The same Mrna technology that's used in the Pfizer and Moderna vaccines could be used to help treat cancer. Specifically, the hope is to make vaccines to prevent re occurrences and fight off advanced tumors. Initially this would help people with melanoma and kidney cancer. There's currently a number of studies ongoing that hope to have some results in about a year or two. For more on how this mrna technology is being used for more than Covid will speak to Karen Weintraub, Health reporter AT USA Today. There's been a tremendous amount of progress in the last decade or so, in what's called immune therapy and turning the immune system against cancer and one type of drug that's been very successful, particularly for melanoma and kidney cancer. Is called a checkpoint blockhead. Basically, cancer puts a brake on the immune system stops the immune system from fighting fighting the tumor and these drugs. Take that break off. So with the mRNA technology can do is sort of add. Add soldiers at gas If once you've taken the pedal, uh, your your foot off the brake. These MRIs can add gas by adding immune soldiers by teaching the immune system to go after..
The Cats Roundtable
The Same mRNA Technology Used in COVID-19 Vaccines Could Help Treat Cancer
"And violence. Second Germany was originally working on. You don't get Let's say you hit a biopsy will take the cancer. They look at the surface proteins or little Like so little skeleton. He's on the surface of the cancer cells, and then they're going to create vaccine to attack those proteins on the surface of cancer cells. So then you'll get a vaccine. There's already one now that Being given from melanoma, for example, and that's helping prolong lives where you basically get a vaccine that creates antibodies that will target melanoma cells. But now with this RNA technology will have it for Lung cancer, pancreatic cancer, and that's all happening now, as uh, fortunately, scientists that Polish demographic woman who worked at the University of Pennsylvania people last time in the beginning And she's the one who's really the basis of all this and already technology and she's uh, basically clean and the future of fighting cancer than preventing just like we have for HPV. Humans have Aloma virus for young
Biz Talk Radio
"melanoma" Discussed on Biz Talk Radio
"Patients with this disease so much more effectively than in generations Past. Welcome, Thank you so much, Kristen for having us Thank you for having us my pleasure, Doctor home my army to start with you. Now we've all heard the phrase melanoma before. But if you would, what is advanced metastatic melanoma. Yeah. Great. Thanks. Question for this question, and believe it or not, I see patients in my practice. Every single day We've been diagnosed with that and very often. Melanoma arises from a mole, so from a pigmented lesion on our skin that becomes cancers becomes malignant. And when that happens, the cells gain access to deeper tissues within our skin, where we have blood vessels and lymphoid channels from which the Celts and can travel to the west of our body, typically locally, initially, first to the lymph nodes and from there can spread literally anywhere in our body, like lung or liver or bone convey really rapidly affect very vital organs. And when people say you know the risk of dying from melanoma, it's not so much from the skin cancer per se. But it is from its propensity to affect vital organs that are inside of our body. Okay, Now, you may or may not know we've just met here, but I'm a hyper contract of the highest order. You think you've met them before? But like here's Chris, and Here's the rest of the world, The Lord. So when I see anything hinky like what you're describing the first gear that I slide effortlessly into is freak out completely. So talk me down out of my tree. If you would, and in all seriousness, tell our listeners what are some of the symptoms and the common risk factors. We should Look out for. Yeah, So, Chris, I don't really want to talk you off that tree. It's good. You cannot be more hyper aware of this illness, and then then you are because we're really facing the opposite animal that most patients who have very significant various quote, ugly skin lesions think. Oh, that's not a big deal. You know, so anything that is on your skin that is misshapen that has jagged edges. It might be ulcerated when you actually have experienced some bleeding from the lesion anymore. That is changing in its appearance should really be brought to the attention off your healthcare professional. Your primary care, doctor, you dermatologist as soon as you are, we are those changes. I love the doctor. You get me so well. Don't change, Chris. That zz advice for me to follow in all seriousness, casting gonna slide to you if I will tell our listeners, please how you became part of this Amazing melanoma research Foundation. How did you get to be part of this? So in 2011? I was actually Diagnosed with advanced stage melanoma. It was not a lesion that was on my skin. It popped into my lymph nodes often times If you don't catch a lesion in time, it can regress back into your skin and travel through your lymphatic system and have a distant metastases and cheer lymph nodes. So I found a lymph node under my arm went got it checked out. I had great doctors, who then removed it after another cancer. I had a second cancer after that, But after that I couldn't work in the regular life anymore, And I had to do something about this and share the story and make sure that People were aware that this just wasn't skin cancer, that it was something that was fierce and needed to be dealt with. So I went and kicked down the melanoma research foundation's doors. And here I am today. Amazing now, so you have a first person. The difference between you and other people is you saw symptoms and you gotta checked out. There's so many people out there saying, I'm sure it's nothing. I'm not gonna worry about it. Let's give it a couple more months, and you are your own best advertising. You got to taking care of yet you kicked the door and so to speak. But here's a question for you Talk to me person. Only if you would What are the mental and the physical and the emotional challenges. Forget financial challenges, every type of challenge across the spectrum that patients are going to face When they're diagnosed with something like this. They want to put it in the rear view mirror. We live an amazing time. So that's more possible than ever. But talk to me specifically regarding your own experience. What those types of challenges patients have to face. Absolutely. So, you know, when you're when you're going through initial diagnosis, you know you're thinking. How did this happen To me? This is impossible. I am invincible. Why did it happen to me? What's going to happen to my family? What's going to happen to make Children? Where am I going to go for treatment? What does treatment look like? Um, I going to be able to endure this. There are shock. There's fear there's depression. There is a sense of just not of losing control, not knowing that you have control of your own life anymore. And so there's there's some of the things that I went through. And the reason that I work for the Melanoma Research Foundation is because they offered So many great resource is and support for me during that time that I wanted to continue along with them in my journey throughout the remainder of my life and be able to offer there's great resource is to other people who are facing the same thing I face and you led me right to the next question. Talk to me about today's fantastic support initiatives out there. Thanks to people like you the educational support and the emotional support what's available out there for patients and families who are new to this. They want to put it in the rear view mirrors well, they want to utilize every tool that they may not even know it. Out there talking about that. Absolutely So. The melanoma Research foundation offers a vast word resource is for for folks who have been just diagnosed all the way through survivorship for this horrible disease, such as patient and caregiver guides. We offer a patient forum that let you talk to somebody who's been there done that that can help you navigate through. You know what the next stages of your journey are going to look like a map that helps you Find treatments.
POLITICO Dispatch?
EU regulator reviews AstraZeneca shot and blood clot links
"Up the astra zeneca ccp virus vaccines. They're investigating the doses as a precaution. After one person died. Another was sickened following inoculation. Basically austria suspended a batch of astrazeneca vaccines after some reports of some unusual blood clotting events and then a few days later we saw denmark. Basically say we're gonna stop vaccinating with astrazeneca completely Toya melanoma some other. Nordic countries made similar announcements and over the following week saw more and more european union countries said. Oh yeah actually. Let's just hit pause. The authorities in the republic of ireland have recommended temporarily suspending. The use of the astra zeneca vaccine. One investigations are carried out into four new reports of blood closing in patients who received the job in norway. Well then on. Monday saw kind of the big powerful you. Countries france germany italy spain also that they were gonna pause vaccination update on some breaking news and france germany and we have now joined the eu countries to suspend the rollout of the oxford astrazeneca covid vaccine and meanwhile it's important to say that regulators weather we're talking about the european medicines agency or the world health organization. They've said look so far. We haven't seen any evidence that these blood clotting events are caused by the vaccine. Just because you get a vaccine doesn't mean that you're protected from every other normal thing that can go wrong. The latest data from the european medicines agency shows that out of five million astra zeneca vaccinations given across the continent. That have been thirty. Reports of people suffering a blood clot soon afterwards but in a population of that size you would expect five thousand people a year to develop blood clots even without vaccination obviously cardiovascular. Problems are are pretty common and the argument from astra zeneca is that. Hey look actually. These aren't happening anymore than than we would predict to happen. And kind of normal circumstances in the general population. And you're also not seeing more issues with these vaccines than with other virus vaccine. So why are you picking on us So like let's say Instead of vaccines we were. We were talking about sports drinks here. it's sort of like a situation where some people who buy gatorade happen to get in car accidents and then everybody decides. You shouldn't buy gatorade because you're gonna get it in a car accident but at the same time like people who get other sports drinks are also still getting in car accidents. So potentially and and probably. That's what happened. But the and other regulators around the world including the world health organization are really looking at this closely and trying to figure out what's going on and the reality is that there have been instances where vaccines do cause problems in a very rare number of cases. But the other thing. Is you know this could also be caused by the coronavirus itself and the argument that many are making including at the who and at the european medicines agency is corona. Virus is a serious deadly disease. So if you're thinking about risk versus benefit which is the way a lot of drug regulators. Think it's still worth the risk that maybe a tiny number of people will have these blood clots in exchange for the benefit of of so many more people being protected from an even more dangerous. It's fascinating so you have. What could be a small risk. Might not even be a risk associated with vaccine but you still have this huge domino effect of of countries. Pausing the shots. I mean at this point. It sounds like almost most of europe isn't giving astrazeneca at this point. Yeah it's at least seventeen at this point. And that's out of twenty seven countries and perhaps even more importantly that includes some of the biggest most powerful countries ones that have their own regulatory system so a lot of the smaller. Eu countries really rely on the european medicines agency where as countries like france and germany. Kind of have the power to make their own decisions. But we've at the same time we also saw spanish official. The spanish health minister say that spain actually has not even seen very many of these cases at all but sort of because they saw these other countries doing it. They felt pressure to as a precaution. You hear the word precaution a lot. They felt pressure as precaution to hit. Pause wow it just seems
WBZ Morning News
Imprisoned ex-FBI agent who worked with Boston mobster Bulger seeks release
"40 year prison sentence for alerting mobster Whitey Bulger that he could be implicated in a mob murder wants to be released from prison on medical grounds. John Conlee will ask the Florida Commission on Offender Review Wednesday. To release him. Huntley's lawyer, telling The Boston Herald. His 80 year old client has melanoma and diabetes. Conley was convicted back in 2008. Of second degree murder after a mob hit man killed world highlight President John Callahan in Fort Lauderdale trial evidence showed Conley tipped off Bulger. The Callahan was about to implicate the gang in another killing. 6
WBZ Morning News
Imprisoned ex-FBI agent who worked with Boston mobster Whitey Bulger seeks release
"FBI agent John Connolly is asking to be released from prison on medical grounds. Connolly is serving 40 years for warning former Boston mobster Whitey Bulger that he was about to be implicated in a mob hit. Connelly will ask the Florida Commission on Offender Review Wednesday to release him, his lawyer tells The Herald is 80 year old client has melanomas and diabetes that Connolly was convicted back in 2008 of second degree murder after a mob hit man. Killed. Uh, A, um, A, uh John Callahan in Fort Lauderdale. Excuse me. Trial Evidence show, Connolly tipped a bowl jer that Kellyanne was about to implicate culture in another killing.
Purity Products
Imprisoned ex-FBI agent who worked with Bulger seeks release from Miami prison
"For alerting Whitey Bulger that he could be implicated in a mob murder wants to be released from prison on medical grounds. 80 year old John Connolly is serving a 40 year sentence. But we'll ask the Florida Commission on Offender Review Wednesday to release him because he has melanoma and diabetes. I'm Dan Watkins. Well, I
Science Friction
This top cancer scientist thought he knew a lot about cancer. Then he got it.
"I wanted. I didn't want to have not only smoldering away in my pelvis. bit also small does away and you hit. It's always in your head as much as i could rationalize it and say i'm very scientific in my approach things and it wasn't a problem every day would come to me at three o'clock in the morning when i sat a worrying about all the other things worry about three o'clock in the morning you will saying parts of them and the body that they will never really say themselves. Also get tonight. It's an extraordinary thing that that was true kind of but it is still amazes me today. That people want to see the inside. Bids cannot have my video. I want to share it on social media. you know. i've seen all your videos on youtube. Can you make sure my prostate goes up in this episode. It's a franken. Feel this conversation about an experience. Men don often talked publicly about. So let's meet the scientist and the surgeon interested in nature. This is professor robe ramsey as a molecular biologist and kansas scientist and on the saudi also makes art. He's a black belt in karate rossi's by his husband father of two children but trying to understand how the natural world works was a i love of his and i've always been driven by trying to understand biology and i'm also a little bit inclined to like machinery and structures and the way things work and essentially sells Machines and i like the way they operate and they're really have siamese different facets to them and of causing disease machinery goes wrong for me. The very first day i was in an operating theatre watching people take cancerous. Lump sexually as it was then breast cancer. I was instantly captivated. This is professor. Declan murphy lading urologist and kansas surgeon. He's been in a for over a decade but you can he he's rh lilt and even though it's cancer he's dealing with everyday like rob. He's loved his job. Died dot. I was in the operating theatre was meeting these patients before and after as a medical student and honestly i just became almost overwhelmed by the idea that people will allow other people to do surgery on them. That it's such a huge privilege to be allowed to do surgery but i was fascinated by urology because it's it's quite a a big field work. In it's everything from the kidneys dancer. The bladder and the prostate and the pain is in. The testicles are all areas in the urology domain that can be affected by cancer. Now dick lennon rob happened to be call. Eggs at the pay to mccallum will pay to mac cancel santa in melbourne as a scientist rob's focused on amongst other tricky conundrums developing vaccines that target gastrointestinal cancers like colorectal cancer as a surgeon declines leading the way with us robotics in the operating theatre and often the cancer arena. You'll find that scientists and surgeons just don't traditionally makes much but robin declan like many others at paid amac a different because i want to do science. That reflects the needs of people with cancer and the clinicians trading them are remember being at a hospital where declan was doing a tag team robotic procedure on a patient was having some colorectal surgery plus a prostatectomy and i was there on saturday morning with my eyes pocket collecting some samples clincal trial without doing their in the operating room because these patients have agreed to be part of a trial in that case. That was a patient to kansas. Quite complex work but rob wanted some tissue as some cancerous tissue to take into the lab. And i was watching these two guys work. Seamlessly together is something is a of beauty in any group of people that do things well together and there's almost subliminal communication. What's coming next that i'm bumping to each other The theater staff all expert. They work as attainments really like a formula one team. It a stop and i'd never. I've never worked in the center where you will have a a professor of colorectal science in the operating room with you so and we get used to that at peter. Mac it's the same prostate the same for melanoma central breast and and i just find as an extraordinary environment. I've never worked in a place that has that. Degree of translational multidisciplinary care where people are. They're asking the questions taking the tissue doing trials etcetera etcetera. And it's just a extraordinary. I can do some cool things in my lab question. I of been geneticists for most of my research life and we can do cool things with jane's in cells and also indeed on animals and you can find great science out of that but does it always reflect what's going on in the patient and the answer is sometimes but not always and i want to the always it is relevant. What happens in a patient. It's all about the patient in the has always westbound lot that though so these two colleagues late in their fields in cancer but then kind of a sudden curve ball and a role change. The scientists in the surgeon were about to become the surgeon. And he's patient he's rob i have a great jp. I've been going to for quite a long time. Really thoughtful considerate kanda guy. We've we always have a great show. When i go to visit him. I have a checkup every six months. For basically blood blood pressure to have a level that cannot be controlled just by exercise and diet.
Weekend Edition Saturday
The Rise Of Gig Work: Companies Turn To On-Demand CEOS
"Experienced executives of doing gig work do is, some companies are turning to on demand Workers to be CEO Zen Piers Yuki Noguchi explains why Duncan Thomas has served a CEO of a medical practice a Russian software firm and logistics company, each stint lasting a few months. It really suits how I like to work, and it suits how I like to engage people and, you know, it gives me tremendous work life flexibility, Thomas fell into temporary executive work by way of a traumatic experience. Six years ago, he was working long hours as the CEO of a vocational college. I came back from a vacation and I was feeling unwell on Guy went to the doctor that day. And that day, they said, You better go down and get an ultrasound. The doctor returned head hanging advanced melanoma, he told Thomas left him about seven months to live. Nine chambers of my lungs and I have three of my liver, and the biggest ones were nine a half centimeters in size, so it was pretty overwhelming. Thomas was trained as a veterinarian and found a clinical trial. A test drug eliminated the cancer from his body. It was almost like a rebirth. Thomas, a native Australian living in Los Angeles, reevaluated what he wanted out of life and work. Working as an itinerant CEO, he says, leaves him time between gigs to recharge with his family. The pandemic increase the popularity of gig work for CEOs. It's left Cos in turmoil and more leaders are willing to trade in a higher salary for short term stints and greater flexibility. Jody Greenstone. Miller is co CEO of the business talent group. It matches experienced executives with interim CEO jobs. Mello says she started her firm because companies in transition or crisis often need temporary expertise. But they don't want the multiyear commitment of a long term CEO. And the notion that I could just, you know, need somebody for three or four months to come in and solve a problem or help me, you know, build a new business just didn't exist in a formal way. The fact that so many people Are now no longer community to an office, she says, brought in the pool of temporary executives and the companies wanting to hire them. And what that did is it really opened up the world of talent, but succeeding as a gig CEO isn't easy. High end temps are often flown in to handle crises and scandals. Duncan Thomas has seen his share. The challenges can be very real. Thomas has taken over at firms that were cooking their books or the previous CEO sexually assaulted an employee. Writing. Such ships isn't easy. For starters, Thomas says. Workers often this trust leaders who parachuted in they're suspicious of their motives. And no, they won't stick around. Ah, lot of the stigma that I've come across is that you are changed around. You're a mercenary. That you are only into the money that you don't really don't give a damn about people these days. There's the added challenge of managing teams you've on Lee met online. But Peter woke with says there are also some advantages of coming in fresh make really comment as an outsider, independent don't have favorites that often helps also Well quits lives in Chicago. He's currently juggling two separate executive gigs at a robotics company and an e commerce firm. One of the benefits is never getting that rut of being in one company for a long time. So he says, it never gets boring. You can Noguchi NPR news
Outcomes Rocket
Equipping Frontline Providers in The Fight Against Skin Cancer with Cody Simmons
"Welcome back to the outcomes. Rocket saw marquez. Here and two day. I have the privilege of hosting cody. Simmons is a bio engineer and entrepreneur that has spent his whole career dedicated to bringing new health technologies to physicians and patients prior to his tenure with dermot sensor cody lead commercial efforts for a silicon valley medical device screening startup and also held business development and commercial strategy roles at genetic cody join dermot sensor in may two thousand sixteen as co founder and ceo. He has led the company through raising fifteen million in financing extensive product-development efforts multiple clinical studies and most recently successful regulatory clearances that now allow for the product to be sold commercially. He is an excellent leader in health. Care taken really. You know the advantage of of the advances in digital health to help primary caregivers as well as patience maximize their health cody. I'm really excited to have you on the podcast to learn more about what you guys are up to and more about you. Thanks for joining. I appreciate that and the excitement is shared Thanks for having me today. And like i said very excited to be speaking with you and to have our work featured on your podcast. Absolutely code eight. Now dermot sensor is is. I mean just fascinating evaluating skin cancer in a much simpler way. one on learn more about this as the listeners. Do too but before we dive into that. I love the know more about what inspires your work and healthcare. Sure will i think first and foremost helping patients Is really my inspiration for working in healthcare hands down. I think that everyone faces at least some challenges and frustrations With their job and their day to day work. And i think our company and me personally you know no exception to that would be called work but dinner the day knowing that if you're able to overcome those challenges in your start up and your product is successful knowing that success will benefit hundreds or thousands of patients that is incredibly motivating for me. And i'd say in line with that. I think for entrepreneurs you know. The common expression is that we're supposed to dress unmet needs and as as you've seen obviously from from from all your your work in the podcast. Unfortunately there's no shortage of unmet needs in healthcare and many of them are very large. Ones that fixing not only greatly benefit people's health but depending on the solution also oftentimes i think has a potential to sit health system money and of course patients ultimately pay for parole healthcare whether it's directly or through their employer for private insurance or through taxes that go to medicare and medicaid For sure yeah. And you know we were experiencing so much change and you know. The epidemic has accelerated that change in digital medicine and telemedicine remote care what you guys are doing fascinating and skin. Cancer is a huge problem. It goes unaddressed like undiscovered. It's way too late and so tell us a little about what you guys are doing to add value to the healthcare ecosystem. Sure sure and yet it really is a big problem and you know a clear. Our product is not yet approved by the fda for use in the us but as you mentioned in it is available and certain areas abroad. Who just announced that. Dermot sensor received seamark for sale in europe as well as regulatory clearances australia in a new zealand. So for the u. s. Yeah so that that's been exciting milestone for us and in the us we hope to be approved next year and then after that to start. Adding value to healthcare system in a couple of men was to just address your question so our our company's mission is to improve patients access to effective stink cancer checks as you noted. Writing cancer is very common. It's actually the most common cancer in the united states in melanoma the number one cancer killer of young women fortunately effective effectively skin cancer can be successfully treated if it's detected early enough unfortunately the average wait time in the us dermatologist's appointment once a two months and because of that and other cost access issues. The majority of americans report having never been checked her skin cancer in illness. Small fraction of americans do so annually. Which is direct recognition for many of us So our our main objective to fulfill our mission of improving patients accessed effected skin cancer. Sharks is really empower. America's hundreds of thousands of frontline providers primary care providers like family physicians internists clinicians at retail clinics to more effectively. Catch skin cancer Study showed that primary care providers they're not dermatologists and that that they only correctly decides to refer biopsy a malignant lesion as little as fifty four percent of the time but melanoma fighters survival rates. Go from well under fifty percent for stage. Four melanoma to high nineties for stage. one mellon all not so virtual helps detect nominal. Earlier helps these primary care providers which by definition frontline providers right so the patients often in early. That would be huge. So so detecting melanoma earlier. It's this to help a bad dad. Be a huge benefit for patients. Survival and also treatment costs relate stage. No no law can be over a million dollars whereas stage one mellon on the treatment typically just cost a two thousand dollars
Tai Asks Why
Ask Tai Why: Where Do Freckles Come From?
"In. This age press to? How tasks now? I'm saying I shall make. How did I get them thinks How did you get your freckles guts a good one. So our skin has this stuff called melon and basically freckles are little. DOTS. Melanin. Melanin is this light absorbing pigment and helps protect the skin from the sun's harmful uv rays by the reflecting or absorbing and just dealing with this radiation. So. When you have a ten as just the Melanin acting up doing its thing to protect you from the Sun. Some people have more some people have less and that's how the body works. People who are Pale have less Melanin, and that's why they tend to burn instead a Tan. We have these skin cells called Melania sites, which is where Melanin is made. freckles happened when these melanoma sites, they just a little hyperactive and create these really concentrated clusters Melanin like a ten but just a single dot boop, she got them by being exposed to Sun it's opponent of your life and having particular millennia sites go a little overboard on the protection.
Living Healthy Podcast
Dr. Richard A. Van Etten: Cancer
"Please welcome to the show Dr Rick van how you doing. Thank you very much Andrew and Brittany I greatly appreciate the opportunity to be able to come and talk to your talk your listeners today. Yeah. Well, thank you for taking the time out of your busy schedule to talk to us. So we're GONNA be talking about obviously cancer and how you can prevent cancer do your best to prevent it. But as I mentioned in the Intro, most likely someone knows someone who's had cancer or they've had cancer themselves even it's pretty it seems like it's touches a lot of people but can you kind of tell me how many people does cancer impact on a yearly basis? Well. Thank you for the question Andrew. The lifetime risk of getting cancer is approaching thirty eight or thirty, nine percent. So more than one in three Americans will get cancer during their lifetime. So that explains what you said that basically almost everybody is either been personally. Involved with cancer knows a close family member or a loved one that's been stricken by cancer. So some of the statistics nationwide in the United States, there's about one point seven million people diagnosed each year with cancer. And they'll be about unfortunately six hundred thousand Americans will die every year of cancer. Here in Orange County it's interesting that cancer has overtaken cart diseases, the number one killer, and as soon gonNA happen nationwide. So a very very. Prevalent disease what kind of has led to what's led to that trajectory? Why is that happening? Well, actually the the the death rate from cancer has been falling and it's been falling significantly over the past fifteen or twenty years, which is a success basically for the research that's gone into it through the National Cancer Institute and other mechanisms. But the fact that cancer is now the number one killer has actually also reflected progress in cardiovascular disease. So doing which used to be the number one killer. So we're doing a better job at preventing. Heart disease through the things that you know about treatment of the risk factors like high lipids, blood pressure, diabetes et CETERA. Right? Interesting. Okay. All right. So we got some work to do on the cancer and Kinda catch up. And, that generally, like I mentioned usually happens through education funding, which we'll talk about in a little bit What types of cancers are the most prevalent today? I know that you specialize are a believe in like blood cancers by what are the most prevalent that people run into so we can talk both about incidents, which is the new diagnosis that we have each year and prevalence, which is the number of people living with the disease at any given time. But the top four in both categories are pretty similar. So there's breast cancer which obviously predominantly affects women but also can affect men. Then there's lung cancer there's prostate cancer which obviously is a male cancer and the last one is colorectal cancer. Those are the big four. Close on their heels are diseases like skin cancer and melanoma that's particularly relevant for Orange County where we have two hundred and eight, hundred, ninety days per year rate. And after that come some blood cancers that I specialize in, which is mainly things like leukemia lymphoma and Myeloma Okay. What kind of leads to these types of cancers occurring out of those top four that you mentioned, what? What's the biggest contributor to people getting? Is it? Is it just genetics you got bad genes or something in your lifestyle or in your the world around you I guess causing it. So they're. Probably, equal contributions both from genetics and from lifestyle. Okay. When I say genetics I mean the cancer is principally in the opinion of a lot of primarily a genetic disease in the cancer cells have acquired mutations that contribute to their malignant or cancerous phenotype, their ability to grow and attack the body. Most of those mutations are acquired in other words they happened just within the cancer cell and they're not inherited. So you don't get them from your mother or your father. Now there are exceptions there are well defined cancer susceptibility syndromes the most the one that may be most familiar to your listeners is the bracket jeans Brca which segregating families particularly people, of Ashkenazi, Jewish descent that are inherited either from your mother or your father, and greatly increase your risk for developing breast cancer or ovarian cancer so that the risk for women who doesn't ever bracken gene mutation is about one about eleven percent or one in nine during your lifetime. If you inherit one of these genes, it's virtually almost everybody will get breast cancer ninety percent risk over your lifetime. So, this cancer susceptibility syndromes are very important the need. For instance when there's a new cancer diagnosis, you need to take a careful family history and in some cases be referred to a genetic counselor to determine whether testing family members is indicated. Yeah. Well, that's interesting that you bring that up because my wife actually we went through that process, and so she was found her mother had breast cancer and through that process they found out, she had the bracket gene Brac to and then and so my wife decided because they kind of give you choice like do you want to get screened? Do you not like you kind of have? Do you want to know more or or like not and stay naive to it I guess and so what I've discovered, we went through it and is interesting out of the split my wife got it and her sister didn't so the fifty, fifty there and. It. Seems like. It's I think my opinion is it's good to know because now they're just more aggressively screening her and is that typically the case when you find out about something like that, you're more your screened even more regularly than the average person should be. That's right. A change basically changes the surveillance. In it not to make it more complicated. But there are some genes like the broncos where the penetrates which means that the chance of actually getting breast cancer. If you have the have, the mutation is very high I think there it's pretty straightforward to decide whether to get screened. Right. There are other mutations that can be inherited that don't increase the risk that much increase it above the background, but it's not nearly as high and there it's more complicated to try to decide what to do about that. But. My advice to your listeners is to seek the advice of a NCI cancer center in a a qualified genetic counselor. Those are the people best qualified to help guide you through that decision making process right? Right. When you're going through like you said they ramp up the screening process if you had the genetic mutation but how does how did we get to discovering these genetic mutations I? It sounds like you kind of have somewhat of a background like you discovered or help discover this protein that was causing leukemia right and. How does that process even work? How do we make these discoveries? How do you make these? Discovery I was involved in is one of these acquired mutations not inherited, but it came about from studies done many many years ago actually nineteen sixty that showed that patients with this particular type of leukemia had an abnormal chromosome in their blood cells. And when to make a very long story short when that was tracked down, it was shown that the chromosome was actually an a Barrett. That was acquired in these cancer cells that lead to the expression of this abnormal protein. And that protein. Hasn't is an enzyme which means that it has a ability to catalyze chemical reactions. Okay and that particular reaction stimulated the growth of those blood cancer cells. So. That led a drug company, which is today is no artis to develop us a drug a small molecule inhibited the action of that protein. And that That drug which has the trade name GLIVEC revolutionized the treatment of that leukemia so that in the past everybody died of this leukemia, unless you had a bone marrow or stem cell transplant. Today everybody takes a drug likely. And most people go into remission and when they do, they have normal age adjusted life expectancy. That's example would that's Therapy likely that can do to cancer right? So does this all come from these discoveries? Does it come from just? Tons of data over decades like this one you're saying, it came from research started in the sixties and this didn't have until the early nineties. Is that right or wealth the the The structure of the protein was discovered. I'm saying Circa Nineteen, eighty-four which I got involved. The drug development efforts took place shortly thereafter I'm and the was FDA approved in two thousand one. So it's been on the market now for almost nineteen years I and there are many many other efforts in other cancers that are parallel parallel that. The thing that's happened today is because of our new technology and the genomics and the ability to determine, for instance, the genome sequence very quickly that's accelerated the progress that we can make. So what took forty years from sixty two to the drug being approved now can be done in a couple of years. Wow. Everything's happening much much faster. That's awesome. That's great news for those of US living right now.
BrainStuff
Are You Putting on Enough Sunscreen?
"As I record this, it is August which here in the northern hemisphere means hours of outdoor time under the blazing summer Sun. But even though many of us do wear sunscreen to help prevent sunburn skin cancer and the kind of skin damage that the beauty industry calls premature aging recent researches found that we're not applying that sunscreen is thickly as we should hang its effectiveness by about forty percent. Sunscreen is rated for Sun Protection factor or SPF WITH SPF thirty able to block ninety, seven percent of ultraviolet rays, the higher, the SPF, the greater the protection although even SPF one hundred doesn't block one hundred percent of UV light. The problem according to this recent research out of University College. London is that few of US US enough sunscreen to enjoy those high levels of protection. Lead author entity young explained to US via email that to calculate ratings in the lab. Sunscreen is applied thickness of two milligrams of product per each square centimeter of skin. He said, an average woman has about one point, seven square meters or eighteen point three square feet of skin for a whole body sunscreen she will need about thirty three grams or one point. One fluid ounces with three whole body applications a day that's about one hundred grams or three point four fluid ounces. For reference, a fluid ounces roughly equivalent to a shot glass of sunscreen and a large tube of sunscreen holds eight fluid ounces of product. So a person spending a full day in the Sun should use about half a tube by themself. Are you using that much sunscreen probably not young and his colleagues estimate that our real life application of Sunscreen is closer to about point seven five milligrams per square centimeter at less than forty percent of the recommended thickness as a result or not getting anything close to the ninety seven percent protection promised on a bottle of SPF. Thirty. The good news from young study is that you can get away with using less product with SPF of fifty or higher. They found that even the real world application rate of point seven, five milligrams of sunscreen per square centimeter if using SPF, fifty provided considerable DNA protection compared to untreated skin. So does that mean that you should run out and buy the most expensive SPF one hundred or spread your regular SPF thirty as thick as cream cheese on a BAGEL. We also spoke with Ivy Lee a board certified dermatologist based in Pasadena California who explained that you could. But that the best daily Sun Protection Strategy is to keep it realistic. Lee, said I tell my patients to go for the highest SPF possible. That feels good on the skin for daily use. How do you know you're really applying two milligrams per square centimeter? No one knows we don't want to induce anxiety over this we want to build healthy habits. Skin cancer is the most common type of cancer in the United States and exposure to ultra-violet or UV. Light is a risk factor for all types of cancer including melanoma more than nine thousand, three, hundred Americans die for melanoma every year. UNPROTECTED EXPOSURE TO UV light damages the DNA and skin cells leaving them more susceptible to skin cancer DNA damage can result from either a few severe sunburns or a lifetime of cumulative sun exposure. Incredibly the American, Academy of Dermatology reports that getting just five or more blistering sunburns between the ages of fifteen and twenty will increase your overall melanoma risk by percents. and. Lee says that although skin cancer is less prevalent in people of color exposure to UV, light can also cause premature aging they sunscreen use will slow the appearance of wrinkles and age spots for all skin tones. Healthy sun-protection habits include avoiding sun exposure during the peak between ten am to two PM wearing a wide brimmed hat and sunglasses went outside and full sun, and of course, applying sunscreen on all exposed skin even in overcast conditions. For full coverage, Lee recommends starting the day with a cream or lotion type sunscreen preferably fifteen to thirty minutes before you step outside. Instead of measuring out of full shot glass of product, Lee tells her clients to think of applying sunscreen like a massage or can fully into the skin without missing a spot since body sizes vary and product spread. Differently there's no preset amount that works for everyone. Lease suggests reserving spray or powder type sunscreen for fast reapplication on the go the ideal is to reapply every two hours but lease as a more realistic plan is to reapply around lunchtime if you're going to be out all day. If you're heading out on water sanders snow more frequent applications are required because UV rays reflect off of those surfaces. According to Lee it's a myth that you can't burn the palms of your hands or the soles of your feet. Also, tablets and other hand held devices reflect UV light too. So pick a shady spot if you're going to spend some time in the sun scrolling.
Breaking Biotech
Karyopharm Moves to Expand Selinexor's Label
"This week we're gonNA talk about some updates from Lasko. Twenty twenty and then I'm going to focus on either as well as another company called, carry farm, so we're doing a little bit of a cancer focus on the show with this episode last episode. And yet should be should be a pretty good show, so I hope you're keeping safe and everything's going well for everyone. I know that the US in particular has been dealing with a lot right now. Not GonNa get too much into that, but I'm GONNA touch on it for the sake of the market, but. With Dell, let's get right into it. So the first thing I want to talk about is some news from Moscow. And one company in particular that I hadn't mentioned, but they seem to be. One of the bigger winners is adapt therapeutics ticker symbol ad, and they showed phase one trial data of ADP A to m four where fifty percents of patients with Sino you'll. Sarcoma exhibited partial responses. Now they also showed some data in believe lung, cancer, neck, and head cancer, and then also with melanoma, and a lot of these patients had responses so I think it's not only due to the soil sarcoma data, but for a lot of solid tumors they show that they're molecules able to lead to some kind of response, and the shares traded wildly high on this news up one hundred twenty eight percent, and then they didn't offering and as I brought this kind of stuff up before in the past. Seeing positive solid tumor data is huge because the market is gigantic I'm GonNa talk about this later, but in lung cancer non small cell lung cancer, the patient population is like two hundred and eighty thousand patients per year. So when you're thinking about companies that are likely to see big increases in stock you know. Are they looking at solid tumors? That's a big thing that you can ask yourself and if they're going to see some positive data in that than maybe you should think about how you WanNa. Play it. So good to see that from them might might do deeper dive in the future, but another company touch on is allergy therapeutics, and specifically they are a company that is doing an off the shelf cell therapy. And the data they showed isn't in it off the shelf car. T. Therapy so aloe five zero one and they were looking in relapsed, refractory, non Hodgkin Lymphoma, and the to specific subsets of that was deal. As well, as F. L.. And for all of you who've been watching my show, you'll know that as of last week. You understand clearly that deal is aggressive form of non Hodgkin Lymphoma whereas NFL or Informa- is more of a slow growing. Or an indolent non Hodgkin Lymphoma, so in both of these forms, which is better than just seeing it in say the version they saw an overall response rate of sixty three percent and thirty seven percent were complete responders and I believe this is in line with traditional car. T. Therapy in all explain in a second with off the shelf part means, and just before going to that. They also saw that around thirty two percent of patients saw site time release. Syndrome, which is also I. Think in line with some previous. Cardi therapies so. The benefit here really, and he's been approved for a few years now, and it's seen a lot of success, but those therapies aren't autologous cell therapy, so they need to get the patient. Take the blood from the patient isolate the cells, edit the cells, and then infuse them back into the patient,
Skeptiko - Science at the Tipping Point
Is Real Reality Hidden
"I'm your host Alex Karras and today we welcome Anthony Peak back to skeptical to talk about his new and quite amazing book the Hidden Universe in investigation into non human intelligences a book. That is very much about these extended consciousness realms that we talk so much about on this show Anthony as many of you know is not just a very accomplished author and speaker but as someone who truly in every way that I can tell seems to be a researcher. Seeker that is someone who you get the feeling that is really trying to get somewhere with this stuff. And isn't just writing books which are very entertaining and bring us all along on his journey but that this is really a path of discovery for. Anthony and I really appreciate that his latest. The Hidden Universe is no exception. It's packed not just with amazing accounts and stories that you're going to be quite surprised that you've never heard about before but it's also packed with a lot of cutting edge science. That Anthony believes backs up his theories. Now one of the thing I should mention and that is that Tony peak is not someone who's afraid to stick his neck out there regarding his theories and I kinda liked that really because if you really listen to what he's saying I think what he's saying is not that he has all the answers but more that it must somebody sticks a stake into the ground and says hey it's not just about stories. Here's what I think this stuff leads to unless somebody does that. We can't really pull it apart so we all realize that we're probably wrong about all this stuff that the greatest minds of thought about since as long as there's been a human being on this planet but I do appreciate that. He's willing to stick his neck out there and say. Hey here's how I think it all fits together so anthony. It's great to have you back. Thanks so much for joining me. Great to be chatting Te- again Alex. I've been looking forward to this. Pretty good. And thanks for a wonderful introduction. The that's a really hard act to follow. I have to say that. Thank you for it but you totally deserve it. I mean so I tell you what. Let's dive into the book. I love this quote that really Kinda resonates with something. We all know to be true but we can forget until a book like this comes along and reminds us and that is throughout recorded history the belief that humanity shares this planet with a variety of other sentient beings has been persistent. I mean if you want to start from there if you want to start anywhere you like tell us about the book the Hidden Universe. Yeah no that that is. That's quite correct. And that's being my my overall reasons writing this book. Book I think has been inside me since the mid nineteen sixties. It's it's the book I've probably always wanted to write. Because in mid nineteen sixty S I came down with a double pneumonia during that period. I had a series of very profound to loose nations going through the crisis. Pneumonia and at that time even my twelve year old mind. I was fascinated by the nature of the hallucinations received. That were these things. nations internal generated or whether mixture. Both and it's very much as being something. That is intrigued me all through my Brighton career. Because time and time again I come across people who encounter ends in differing circumstances in OB estate in Dreaming States people who encounter entities during closing campuses of the third kind ending. Play developing close encounters of the Moments I the seems to be an awful lot of information out there but what? Nobody's I think is trying to do. Well it's not true. I mean I'm not originally Jackley trying to do it. Many years ago and various other writers over the years tried struggling through history as to what events debate on. This is what I try to do now. I very much. I mean you Coul- my ideas a theory also or high policies. I'd probably sites educated speculation because these things we can never actually know and we can never really asked them working with people trying to test these things but the basic base to the book is just if people have extraordinary experiences encounter entities that seemed to having been existing so then can we build up a neurological model. Can WE BUILD UP A PSYCHOLOGICAL MOBILE? And can we build knowledge comodal to actually explain things all? And that's what I intend to do in the book. Tell us more though. Because that's that's a good starting point but the book really jumps in with both feet about the entirety of this extended realm. That does seem to crop up all over the place. So whether it's magic and spirits and Shamans like you said or whether it's after after life experiences in near death experiences or whether it's the experiences I mean you do kind of take us through this history in order to get us to the point of some of the breakthrough science that you think is influencing you the most right now. So where do you WanNa start with that? I I think the magic and spirits and Shamans thing is something that's really interesting because it grabs a lot of people's attention right now. There's a lot of people really interested in magic right now. A lot of people. Really Interested in the occult right now and I gotta say. I think that we haven't quite thought that through all the way particularly if we mashed into simulation theory and afterlife near death stuff. I mean there's just so many things to pull apart here. Tony hardly know where to begin. So I'm kind of looking. I'm happy to do that. The the first thing I'd like to make a point is the kind of the starting point. The starting price of the book involves inexperienced. Mother had when she was starting to develop out signs and one day. She phones me can. She said she experienced a very strange incident on her way. Onto the local village that we used to live in name livable and she said that she walking with my aunt. My aunt sold tie shoelace. When my aunt Stein tying issue my mother looked up and said what she described to saying a smoke ring. Hong Hovering over local local factory. She then said the smoke ring salty to revolve then shut off towards North Wales unjustly. Won't she scene and I said well you know I don't really know him you know she's not into. Ufo should never have these not the kind of thing she's ever been interested in James Lady and then unless we'll worry about it and she didn't have two or three days in the morning feed as she phones. We opening statements of absolute terror. Now she's woken up in the middle died This you know she. She said she couldn't. She moved properly but she was looking towards the door of bedroom. Now she lives alone. She's away now. What is important here? The important caveat is that she'd lost heroin with malignant melanoma many is before and Harare. She was developing various problems so she was partially science which is important. As as I'm involved with this. She said she looked towards the bedroom. Two bedroom door was an end she. She's fingers around the edge of the veteran Dole and this creature pods head round the door. She described it on. The description is uncanny. She said large black is like insect. She had two holes for nose and a slit from mouth and looked at her and dodge FAC. As if you know seen her she wakes up and she said Tony what did I say and I say well. It's intriguing I. I really don't know them because I didn't want to worry her clearly. In a state of hip Negi ornamental. Punks anesthetic sleep paralysis. Her Dole's perception and broken down to such an extent that she was a seeming. Something that ordinarily alternate Circumstance experienced of it and of course of the book cover of the way straight communion. Because it was it was a classic right it was an all CGI type will gray now. I started to research into this world were when I started to really quite interesting. Facts like for example in twenty seventeen in northern India Louis caved in India Tango. Being ten thousand years they call been dated various things to note. This was the case and the creatures that are depicted in this cave creature my mother. So then he'd go. On Your Graham Hancock congratulating books events natural and then they see describes his own experiences in the shelter in the Here again. We have very similar creatures. That are actually drooled on the cave wall now. What intrigues me? Here is that there's an elderly lady in in the UK. There are people in India under people in Southern Africa. And then again Graham. Hancock says itself. You know you look at a last caves and you look at Pash Mel everywhere else. These these entities seems to be everywhere of the counterargument today sees a well. You know they. They were more expensive than we were these people. They didn't know how to drool pro bowl. They would doing idealization xlt now. The argument doesn't stand up for me because these these ancest- these ancestors of the brain's rejected the same sizes. Clearly that you had to be Faisal and and other animals soclean whatever they were doing. It was not just an abstract. It was something more.
WTOP 24 Hour News
What causes melanoma? Study ranks states by melanoma rates caused by UV exposure
"Look at the number of melanoma cases related to UV exposure and more women than men were diagnosed between two thousand eleven in two thousand fifteen doctors blame the popularity of tanning beds in the late nineteen nineties a study also finds Maryland among states with notable rates I why has the greatest number of melanoma cases per one hundred thousand coming in at sixty five Alaska the least at fifteen the study published in the international journal of cancer finds Maryland's melanoma rate of thirty two point six is notable higher even than Florida's twenty nine point two researchers say lots of factors explain state by state variations such as the popularity of outdoor activities early detection indoor tanning and how diligent people are about sun protection Kristy king