17 Burst results for "Mark Mattson"

"mark mattson" Discussed on FoundMyFitness

FoundMyFitness

04:56 min | 3 weeks ago

"mark mattson" Discussed on FoundMyFitness

"Before the male starved anez it'll be advantages to them to be able to inseminate as many females as possible before they die of starvation. So they stay for so. That's my interpretation of that you know. The female has the Potential passing gene on and off but and then back with intermittent fasting. They kept cycling and their activity in the cage. Increased a little bit but they. They maintain pretty good body fat. Compared to the forty percent calories friction one one issue is of plies mainly to adolescent girls lesson girl. Stay intermittent fasting eating pattern. Would she be more prone to developing anorexia nervosa which besides compulsive like psychiatric disorder. The answer is we don't know we just don't know from an evolutionary perspective. You would think that would be selected against and it's not clear. I guess i i don't know enough about anorexia But how back in human recorded history. rexona bosa even commoners. There's something that has arisen. More as girls are more conscious of their body image in salon. And therefore there's this psychological factor that i don't know if that's something that i guess what i'm saying it doesn't make sense to me that annan erected those would be something that would not be strongly selected against during evolution right because these girls. They usually quit cycling too. So i guess we just don't know out on. The one hand intuitively say one. Be a good idea to recommend this to adolescent girls but if there with obesity or overweight i don't know why we just don't know i think seems like may be okay but we just don't know you talking about with adolescent at well. So what about women that are not at lessened and are you do not have an eating disorder and Are perhaps even normal weight not obese or overweight. Is there a concern with other hormonal imbalances. I don't even know necessarily. Is it a bad thing. I mean if you're a manorexic for a short period of time In you go back to eating normal calories. What does that mean do you. Do you do delay reproductive lifespan longer. Or is there even implications that well in animals. That's what happens. If so for example were take these rats and do forty percent kayla restriction for three months four months so that they stopped cycling. And then you put them back at lebanon feeding again their body weight back. They started cycling on our studies. Things are other studies then. Those rats will be able to have keep cycling to older age than they would have previously. Stop cycling so in other words in theory. Maybe could extend age of menopause by shutting down cycling for ten years. I this is like this speculation. This thinking not any. I'm that's approaching it coming close to even encouraging someone to do something like that which should be crazy. But it's interesting thing to think about. I don't know of course there haven't been studies. This is a big thing. That's lacking in in. This field is studying hormones except for like simple things like leptin example f. Shala show oxytocin anything produce out. We do do no.

anorexia nervosa obesity kayla lebanon Shala
"mark mattson" Discussed on FoundMyFitness

FoundMyFitness

03:07 min | 3 weeks ago

"mark mattson" Discussed on FoundMyFitness

"Been documented by doing. What's called functional magnetic resonance imaging and kids with autism kids with autism have a huge increase in incidence of seizures. I should say not. All kids with autism are born to women with obesity. Type two diabetes. Not all kids with autism have seizures about. There's a big increase incidents that is more kids with autism ab seizures. Then kids don't have autism and then an animal studies. There's some genetic miles that are actually pretty good for autism. There's something called fragile x syndrome and the gene is known for that and when that gene abnormality is put in mice. And then you. You put the mouse in a cage which a bunch of other mice. The mouse goes in the corner doesn't want to interact with other meisam. In kind of measure this propensity la interact so kind of social withdrawal and and those mason their brains they have hyper hyperactivity of gloom Neuronal networks so there is some evidence that kids with autism. Exercise can help them. Certainly we know. I know i used to coach. High school cross country in my kids ran. And i know that during the cross country season the kids are their mood is much better than when they're not running. They're more relaxed less ornery and So right and then the exercise and intermittent fasting up regulate the gabba tone kid. Johnny guys will do that too. So ben resting. I think it'll be interesting to try. Intermittent fasting and kids with autism. Perhaps kinik diet as well very very interesting mark to kind of shift back to the women part of this story. There's been a lot of questions about whether or not fasting affects women differently at different than men. And you know if women if women Should should fast or if it affects their cycle menstrual cycle or hormones. Thyroid things like that whether we're talking about like Internet fast. That's more more Straw like longer than temperature to eating something more. Like a maybe twenty four to forty eight hour or perhaps even more prolonged fast. Do you have any thoughts about that. Yeah.

autism seizures obesity diabetes mason la Johnny ben
"mark mattson" Discussed on FoundMyFitness

FoundMyFitness

03:14 min | 3 weeks ago

"mark mattson" Discussed on FoundMyFitness

"It used to be that. Obgyn's would tell women that were pregnant. Okay you you should take it easy. Don't overdo it now. You don't don't wanna do much exercise. That's actually the way cardiologists Deal with patients who've had a heart attack is take it easy on your heart but we now know that it's actually good for pregnant women to get some exercise during pregnancy and certainly if they're overweight that's not good Let's something i'm interested in. Published an article on it So women with obesity and type two diabetes. There's increased risk of autism. Having a child who's that third is on the autism spectrum disorder compared to normal weight healthy women. And that's very interesting. I can send. I don't know you can put stuff on your website. Rounder right absolutely so i don't need a website. I just go through you. So i'll send you. I'll send you a few articles that you could post on your website zeneca. Yeah and we also post him. On the video we put the figures and study titled information so whatever anywhere else is lying on autism so one one one looks at so we know that in the nineteen seventies and eighties autism was kind of a lot of people never heard what what's autism. What's autism. I did when i went to high school. I never heard anything at school for my parents about autism and Beginning round a nine late eighties nineties and then more so there's increase incidence of autism. Some that's due do increase recognition that the kids are having trouble concentrating. They're avoiding social interactions. And so on. But that doesn't seem to explain. All of the increase turns out. There's a nice few tra. They increase incidence of autism and the increase in maternal obesity and type two diabetes tracks. Really while you know through that you know from very little maternal obesity in the seventies and eighties and then increase increase autism. Then so the neuroscientist have good evidence that with awe in autism during brain development in the embryo in the uterus. The brain grows more rapidly than normal and probably.

autism Obgyn zeneca heart attack obesity Rounder diabetes maternal obesity
"mark mattson" Discussed on FoundMyFitness

FoundMyFitness

04:14 min | 3 weeks ago

"mark mattson" Discussed on FoundMyFitness

"Seizures even stroke. In in some instances a third reason is it's easy to study the is actually relatively simple compared to the cortex so we can put elektra login Ignorant here and we stimulated glutamate turkey down here in we can record that we can activate gabbard ignorant and record reduction in activity so anyway what alexis found was that i what she did. Is she major. The number of synapses along. Dan writes the part of the neuron receives information coming from another neuron so she simply counted. Not simply it's actually takes a lot of work but counted synapses and found that the two things one the diabetic nice regardless of whether they were intermittent faster than or running wheels in their cages. had look smaller number of synapses than did the normal mice. Then she found that the running we'll exercise and intermittent fasting increase the numbers in absence in the combination of intermittent fasting plus running wheel got a further increase in the number of synapses. Okay so that suggests that intermittent fasting can enhance the effects of running an increasing number of synapses between neurons. And then she took the other hippocampus from the brain and measure beat enough levels and i mentioned beat enough important for learning memory. It's actually also important pore formation of new synapses and she found that the intermittent fasting end the exercise. Each alone increased beating-up levels in the combination. Got a further boost obedient f- levels She did not find that. In the diabetic mice synapse levels came up to the level of normal nice. You know so. There was some beneficial effect. But you couldn't get back collect. They weren't diabetes diabetic okay. So that's one example then. The second example has to do with endurance exercise. And this work was done by a former post-cap christina morosi anna post back fellow akilah. So this can you see this yes. Can you see the whole picture i can. Yeah so this is about running grow from the lab about twenty sixteen or something anyway so the work i'm going to talk about now is done by. Keelan mold and christina morosi casinos. Not on here. She wasn't fast enough to make our eighteen. So celebs what they did is they took mice and they had four groups adlon sedentary these were all normal mice alim sedentary Them daily treadmill training for forty five minutes every day for two months then. She had a group every other day fasting no treadmill training and then the final group gloves taylor treadmill training while they're on every other day fasting for two months and then at the end of the two months they did a maximum endurance test so forty five minutes on the treadmill then every week they increased neither the speed of the treadmill or the incline so they're actually increasing the work for the two months so they did maximum berenson tests. How long can the mouth stay on the treadmill without giving up and they found that as you'd expect the animals that have not done treadmill training.

christina morosi gabbard alexis anna post akilah stroke Keelan mold Dan diabetes berenson
"mark mattson" Discussed on FoundMyFitness

FoundMyFitness

03:44 min | 3 weeks ago

"mark mattson" Discussed on FoundMyFitness

"And we found that the most striking effect was in the mile of epileptic seizures where we administer was called an exciting toxin. it's They're interesting storage. Naturally occurring chemical that's produced in algae and it's levels are cumulated berry high levels during red tide seasons where it's dry and so. There was these incidents in unanswered in canada where these people who had eaten shellfish at a restaurant develop memory loss amnesia in it turns out scientists trace this to the first of the shellfish laid all eat shellfish and then the shellfish had high levels of this excited toxin s- called molik acid and they had high levels because they are eating the algae that had high levels so as you go up the food chain toxins accumulate. Anyway make a long story short. The intermittent fasting protected against epilepsy seizures and protected the neurons from being excited to death. And we now know that there's a role for key towns. In protecting nerve cells against epileptic seizures in fact clinicians neurologists in some cases still prescribe ketogenic diets for patients with epilepsy. That aren't don't respond well to the epileptic anti-epileptic drugs. Okay so go ahead. Well i was gonna ask about whether or not you thought you know this metabolic switching which you know you're you're talking about your metabolism switching from glucose metabolism to metabolising fatty acids that are released from adipose tissue and You know in the liver you know that that produces the ketone bodies such as beta hydroxybutyrate. you know if that is something that can occur on akita. Genyk diet do you. What are your thoughts on the benefits of this metabolic. Switching from intermittent fasting. You know in terms of you know. Can you get similar benefits by just doing a ketogenic diet or their differences between the intermittent fasting and the ketogenic diet. My opinion is let you can get some. But not all the benefits of interim fasting with akita. Jenny die early on. I talked about how increased activity and neural networks is good for neurons and with intermittent fasting. There is evidence during the fast thing. There's actually some increased leasing some neural networks and Activity neural networks. I guess that kind of makes sense from level luminary perspective that if you're an animal and have been able to get food for a long time your brain cells that'd be active. Your brain better be better be alert. You better be motivated and you better be thinking cognitively on where i go to find a prey animal or to find fruit Trees you know based on you know so. The ketogenic diet will not cause that increase in rural network activities key. Jenny die at one thing. It seems to do is enhance Activity of what's called an inhibitory transmitter. Call gabba semi give some neuroscience one one. Let me ask you random. I'll ask you that. I asked this question to people this out of curiosity and actually writing a book on this now. Second book name. Neurotransmitter.

seizures epilepsy seizures Genyk amnesia epilepsy canada Jenny
"mark mattson" Discussed on FoundMyFitness

FoundMyFitness

04:41 min | 3 weeks ago

"mark mattson" Discussed on FoundMyFitness

"If you need qualified medical advice please seek it out now. Let's get onto it. Welcome back to another episode of the fitness podcast. I'm sitting here with dr mark mattson. Who is an adjunct professor of neuroscience at johns hopkins university mark. I'm so glad to have you here today. This is A long overdue podcast. I've been a huge fan of your research. As a scientist you have made decades of contributions to our collective understanding of the benefits of biological stress and the supporting evolutionary theory of why almost all organisms actually need stress to thrive. There's a variety of topics that i know you to be an expert on that. I'm really excited to talk about with you today. Including your understanding the place of plant phytochemicals and our genetic responses to them from a practical and theoretical perspective your take on how the decades of caloric restriction in animals has panned out and our attempts to translate that those research findings to humans as well as intermittent fasting as a metabolic switch that has implications for overall health and particularly for brain health. So perhaps to kick things off. Maybe you could explain why humans need some biological stress. And and how maybe modern day society has made that difficult to achieve your during evolution organisms evolved in environments. That were very stressful. Even the simplest of microorganisms like bacteria where they had to be able to tolerate changes in levels of salinity in the water of.

dr mark mattson johns hopkins university
"mark mattson" Discussed on FoundMyFitness

FoundMyFitness

01:56 min | 3 weeks ago

"mark mattson" Discussed on FoundMyFitness

"Hello friends i'm excited to share a new interview with dr mark mattson. Dr mark madden is an adjunct professor of neuroscience at the johns hopkins university school of medicine and the former chief of the neuroscience research laboratory at the national institute on aging he is one of the most cited neuroscientist in the world with more than one hundred eighty thousand citations of his work noted. In the scientific literature dr matson's rigorous work has advanced scientific understanding of brain aging and identified fundamental aspects of age related neurodegenerative disorders including alzheimer's disease parkinson's disease his most notable contributions however have probably been that his role as the father of poor. Mrs and intermittent fasting. Four which is extraordinarily well known at the start of the interview. You'll hear a little bit more about why i was so excited to have this conversation with dr mattson. We're trying something new today with this episode and releasing the interview audio i exclusively on the foundmyfitness podcast feed for those of you listening. Also enjoy our in-depth video interviews. Don't worry we planned to release the full annotated video version of the interview very soon as many of you already know the post production work that goes into our videos is quite intense. And we just couldn't wait to share this conversation with you onto the important stuff in this episode. Dr mattson and i discuss. How hormetic stressors. Dr adaptation and prevent physiological complacency. How intermittent fasting improves health by promoting metabolic switching. How daily time restricted eating and five to weekly fasting compare how a genyk diet and intermittent fasting differ in terms of brain effects how exercising while intermittent fasting exerts additive effects. How plant based bioactive compounds induce hormetic stress..

dr mark mattson Dr mark madden neuroscience research laborato dr matson alzheimer's disease parkinson' johns hopkins university schoo national institute on aging dr mattson Dr mattson
"mark mattson" Discussed on Power 106 FM

Power 106 FM

01:42 min | 8 months ago

"mark mattson" Discussed on Power 106 FM

"Rookie year, you know, I was gonna be. Oh, well, that's what I want. You probably hate you it up. All right. Come on back. You're the big diesel. You're Superman. But you're out here acting more like the pick. Pity the big troller stroller or better yet. Almost orbited old man too yellow to club. Come on sack. Yeah. How the favor, bro. What happened? The most dominant do in NBA history alongside Kobe. Why you trolling? Why you having a horrible exchanges that go viral. Speaking of Kobe, the mama would never help Michael Jordan whenever Dude. Even Mark Mattson would never shock you to remember people respect you. The current players admire you instead of hitting on them and getting this image of the old man yelling, Get off my lawn. Why not help them? Get to the championship level that you yourself? Worked your ass off to get to stop being bitter and shack just Be better now, Sack. Can you digger on? Why? You added, Enjoy this Well seasoned shut told me how this lt's okay, so because l taste because your order is up by one of six movies, the wounds open security. I'm in here, but it's been a long time. We shouldn't have left you left you went out of Don't meet step to this day. He's fried Accepted. Staff tend to give the baby girl to get to me. What would you say? That way Would you give up trying to tell a joke, man? You go away..

Sack Kobe Mark Mattson NBA Michael Jordan
"mark mattson" Discussed on Bulletproof Radio

Bulletproof Radio

07:23 min | 9 months ago

"mark mattson" Discussed on Bulletproof Radio

"You know and they're not addicted these cha. In contrast to the opioids right which is a huge problem. These chemicals and mushrooms seem to have some interesting effects on the nervous system. are not addictive. Which would seem to be a big advantage. It seems nonsensical that alcohol. Yeah cotin and the. Opiates are legal and caused a lot of harm. But i don't know anyone could be really addicted to the strong hallucinogens. There are people who disassociate because they're so traumatized but these are it sounded addiction. That's that's just deep seated trauma response which is a different animal. At least that's my wife says so she's a caroline ski train drug and alcohol addiction. Emergency doctors. i'm going to believe her there. Which is there are people who abuse them but they're not addicted versus actual addiction. I'm all right. I'm I'm really interested in compounds. That i know that you're interested in a nerve growth factor in jeff and beady enough brain derived neutral big factor in. I wrote about those headstrong. And i've used There's old studies on mushrooms. There's a compound he's one of my supplements from the fruit of coffee. A polyphenol that raises. Pdf coffee itself probably does according to some other research fasting. I believe raises. Pdf can you walk through your perspective. On increasing nerve growth factor in brain avenue new trump. A factor. What do you believe works. And how important is it for living along with a good brain both bedia nath and ngos are important for the development of the nervous system for the survival growth synapse formation and then the fine tuning of the structure of the brain during development eliminate the genes of either ngo or beat enough from mice. They died during development. So they're critical in the adult brain. Upbeat enough is particularly important. Throughout the brain all over the brain in promoting the growth survival of neurons it's critical for learning and memory And it's also we showed in my lab. When i was back at the university of kentucky in the early nineteen nineties that beat enough protects nerve cells against various types of stress oxidative stress metabolic stress. Something we call excited toxic stress which is Unconstrained neural network. Activity like occurs dramatically. Epilepsy see but we think to less dramatic extent in brain aging and alzheimer's disease so And on the other hand there are only a small but important group of brain cells that are responsive the enough in the adult brain Exercise is a potent stimulator of bef production in the brain. Intermittent fasting stimulates beating-up production and the combination of exercise in fast thing. Get an added of theft in boosting beaten offend student. Alexa strand han. Who showed that many years ago in in studies where she combined running. We'll exercise and daily time restricted feeding a daily short fast and found. She got a added of effect increasing beady announced than actually protecting synapses against diabetes which is and of another angle on this it turns out that obesity diabetes are not only bad for your heart. There are bad for your brain particular. Should get as you get older and we think that intermittent fasting well actually no it. Intermittent fasting an exercise can reverse diabetes and obesity In humans a person can switch their eating pattern and get on an exercise program and and beat enough plays a role in that so in individuals who are obese or diabetic beat enough levels are lower in their brains compared to normal weight metabolic healthy people one of the things that that really changed my life when i weighed three hundred pounds and i was having all kinds of cognitive dysfunction in my twenties and early thirties i started using a thing called the russian sleep machine. A three zero electrical stimulation with alternating current between the is very different than the we now and it turns out there are studies that show both. Td's yes and us cbs. Or alternating current raise beady enough very meaningfully and senator us. Yeah i'd go to sleep with this thing. And i swear my brain health to turn back on and Now at forty years in the brain upgrade place that i started we use a clinical grade. You neuro science level System that lets you have specific frequencies that are tuna -able and controllable by a computer. And we do that to prime the brain for For better learning of altered states that you enter neurofeedback and you go all the way down to companies like halo. Who's been on the show. Who makes you know. Td's headset when i do exercise I especially lately. I can't. I can't keep up very well with my nine year old. Ping pong can ping. Pong is a high reaction. Time thing keeps her brain young. Dr ayman told me to buy the ping pong table. I did so. I started all right. I need some more beaten up here. Like my my son's kicking my butt. And we've got the carbon-fiber paddles and we're going at it. Like easy good either veteran bad I was not a good competitor. A for him. So i started running the electoral kern over my brain again using the halo and also my learning went up in twenty minutes after doing it. It's like the ball slows down. And i i can hit it. And so i believe that a beating of sort of thing but if you seen electrical stimulation magnets lights of go to the bottom of swimming pools. I don't any other crazy tech like that. That's going to make our brains more plastic that the answer is yes and at first. I want to go back to when you. You're young and obese right. And he did this. Alternating current stimulation in your brain. Did your did that. Reduce your appetite. The reason i ask is it turns out that beat enough suppresses appetite interesting this is i don't think it.

trauma response bedia nath alzheimer's disease Alexa strand diabetes obesity university of kentucky jeff Epilepsy Dr ayman cbs Ping pong swimming
"mark mattson" Discussed on The Intermittent Fasting Podcast

The Intermittent Fasting Podcast

02:45 min | 1 year ago

"mark mattson" Discussed on The Intermittent Fasting Podcast

"To make that switch, and if you are metabolically flexible if you're doing a kid genyk diet that seems to make it. Kita Genyk Diet. So you're always kita all the time your body's not really going by like gin at all for when its you know genetic certain amounts of key towns. But when you're are eating CARBS, if you're metabolically flexible, glycogen might not be playing as much as quite a big of a role in having to hit a certain depletion number before he switch. Over. But if you're metaphorically inflexible you gotta go through that you know got deplete I would really encourage everybody to defined that Mark Mattson article and read it flipping the metabolic switch and dig into that dig into their references get through that and see what you can come up with yourself. But I do think Adam is correct that if you're not fat adapted. You could have some issues, but that's the whole point of of knowing that you're going GonNa get to the other side of the bad adoption period. That's the whole point of the twenty eight day fast start in vast repeat is that your your body is learning how to become founded apted and that's the part that takes time and it can take more than twenty days. If you're somebody who's very metabolic inflexible, that's just like a ballpark that you know. You should give yourself at least amount of time for it to happen. But once that switch is flipped using the wording of of Mark Mattson and his paper, that's when you become fatted apted. The whole point is don't worry so much about what is your level of glycogen? Where is it stored? Instead you WanNa flip that metabolic switch so that your body can shift fuel sources as needed and I think that's the only takeaway we really need to worry about. Fast sufficiently so that your body becomes fat adapted and you're able to switch fuel sources as needed to fuel your workout to fuel your day tap into your fat stores I think that's all that matters who yeah because I mean that's basically what I was saying is that it's more about the flexibility that the title of the study that I am referencing is called metabolic switching his impaired by. And facilitated by Ketosis independent of glycogen to to that point what the actually says there what they saying they're discussion as to say, the prevailing theory regarding the initiation of Kita genesis is key to body production is triggered. Once the by depletes agent stores this depletion hypothesis likely stems from the body's natural response to vigorous exercise or longer fasts and acknowledges that is the prevailing theory but then you're talking about how there seemed to be a lot more a few more nuances and factors involved but for listeners. Yeah we'll put links to all of this and the show notes you can dive in deep like I said just. Sort of my obsession just because..

Mark Mattson apted Ketosis Adam
"mark mattson" Discussed on Bulletproof Radio

Bulletproof Radio

11:26 min | 2 years ago

"mark mattson" Discussed on Bulletproof Radio

"You see in endurance athletes what's happening is a way found by measuring these things the alternative fasting similar to endurance training increases the activity in the Para sympathetic nervous system para sympathy your heart rate is controlled and blood pressure by a balance and and shifting between para sympathetic and sympathetic nerves the system you're para sympathetic nervous system sloughs resting slows heart rate reduces blood pressure you're sympathetic process them increases heart rate and blood pressure and so what's happening with the intermittent fasting is that your heart becomes more adaptable to shifts in load levels for example we did stress test in the animals we we subject them to a very stressful situation where essentially put them in a straight jacket where they can't move okay and so that will cause a big activation of the sympathetic nervous system the flight or fight response their heart rate will go way up but in the animals that are damped adult day fasting their heart rate initially goes up when they're under the stressful situation but then it comes down more quickly apple well after they adapt so they adapt more to the stressful situation when they're adapted Herman faster resilience goes up the let's switch gears a bit we know what you eat now we know how you exercise and how `bout rapamycin have you ever taken it no no no no how about the other anti aging growth hormone testosterone own supplements your head anti-aging guy you study all this stuff you don't use any of it the only thing I'd take it now is a Curcumin K. 'cause I got some knee osteoarthritis and vitamin D and fully gases that's it I mentioned a variety of vegetables fruits nuts so honored so on and the studies we've done in animals at another's manipulating specific nutrients and the ANAIS lifespan studies compared to daily calories fiction or intermittent fasting none of those things have nearly as powerful effects so that's what I'm basing it on I agree with you there quality sleep and so then fasting and immoderate exercise not even crazy exercise are Jain Norma's variables and It does seem though I mean James Clements came on and we we talked a lot about you know increasing autophagy including pharmaceutical stuff Aubrey de Grey the different seven different pillars of aging it it feels like we are making progress on their David Sinclair is coming on this ad pathways on my hundred repair I mean it feels like this brave new world of of anti-aging tack it's it's all just coming online now or am I just a hopeless optimus you know that FRAPP Meyerson is very interesting the NRA has supported three center study of lifespan studies where various people propose things to try metformin RAPA Myers in Cetera et Cetera and they have so goals and Rapamycin is the only one that causes clear highly statistically significant increase in average lifespan in the mice in all three study so in in the animals it's convincing that rapamycin can reese lifespan it's the all a single chemical intervention that's been clearly shown to increase lifespan and what about Matt Foreman I mean that's another one right yeah in the three center there there are some published studies suggesting it increases lifespan but in the Three senators study where all three centers do they did metformin identically over one hundred miles each the they didn't see us statistical interesting I I am completely flummoxed by Metformin I started taking many years ago in the first studies came out from biomarker pharmaceuticals and then I quit because of the B twelve in mitochondrial harm things it's an herb for m. k. I talked to James Clements recently herb isn't so good either so I go back and forth most of the anti-ageing clinicians I know are using it in their practice and seeing you know positive benefits even it isn't life extending they're certainly a quality of life performance in the labs look better but I'm I'm torn on that one yeah that that Glucose Glucose regulations improved certainly but you mostly don't do any of that stuff I don't eat for a while and get some sleep and it gets Chris is it the right time which is at the end of a fast and and you're pretty much good to go with that all right and as far as I know that people in the blue zones aren't taking metformin rapamycin or any of these other things are they're saving their money and still living to be heard and it's Diet and let's that is true at the same time they also live in the blue zones which says if you don't live in a blue zone and you live in a highly polluted city you might want to change what you do you have to match the environment Ah I mean th there's a bunch of theories there's glacial melt water with extra minerals in it there's you know all kinds of stuff around new deterioration depleted some some fringe theories around that there's lifestyle stress and you know the diets are all over the place from seventy percent fat to carbs and I I'm having a hard time using epidemiology to get anything useful Yeah I don't like I don't like it okay mail gets so you're to work had been agreement I wonder how it works and I want to say if you do X. Reliably get why and then I'm going to do X. Even if I'm not a mouse and see if I get why and if so I'm just GONNA have to deal with access better than what I had before which was random random out but that offends some academics because it's you know I'm equals one and then I might be biased I'm biased but I feel good so how do you sort that out I mean I talked to Dr Newhouse who wrote the first paper eighteen eighty eight on nicotine for Alzheimer's from Vanderbilt he's I've never used nicotine like how can you studies under thirty years without taking a little hit of it once right well I do do intermittent fasting right so that's your number one intervention and you do it all right I'll give you that okay the ways to raise key tones externally there's MCAT oils indifference or different things there's kitone salts and different ones do different things in Dr Beach raise the Bio identical issue there I actually had to consult product ready to ship and I canceled it because the selling something that might feel good because harm later but you know there are people who are advocates of them especially short-term use and things like that and then there's the esters witchdoctor beach and I talked about you talked about an actress synthesized some six years ago but their forty thousand dollars a kilo I couldn't commercialism and there's still one hundred dollars for three doses kind of things for people do it is there a risk another way there is a risk with blood sugar if your blood sugar levels are high it doesn't mean that you have more energy and you've done a good thing it means you're not metabolising blood sugar if you're kitone levels are exceptionally high is is there any sort of a similar situation hey there because you can't metabolize them right drain them as fast as you can or should we not worry about my Mikey tone levels are higher than your Akito novels sort of things and this is a good question we know that owns with MCAT's or ketone Esther long-term chronically we don't know I I by current thinking is intermittent elevations may be better than continuous and you know the cycling between actor in an active dependent manner that is it's produced one NERONHA's electrically active and so it's produced lead enough if we transparently apply beat enough to those neurons they produce more acetylcholine heart rate goes now.

sympathetic nervous system metformin Rapamycin James Clements knee osteoarthritis Cetera et Cetera Aubrey de Grey Herman apple NRA Jain Norma FRAPP Meyerson growth hormone ANAIS Matt Foreman David Sinclair testosterone
"mark mattson" Discussed on Bulletproof Radio

Bulletproof Radio

29:42 min | 2 years ago

"mark mattson" Discussed on Bulletproof Radio

"There's they don't taste caffeine as bitter as people were slow caffeine metabolisers which is really interesting so there's some sort of little sub cellular in your heart self interestingly produce beady enough then there's other cells but anyway kind of the bottom line is unfortunate delay unlike tetons which we can easily measure from a finger stick and blood we can't measure beat enough for there's no way in basically to do that so I'm just going by what the Animal Studies today sure editor so again my my normal routine gene is donate breakfast drink a lot of green tea in the morning don't drink green tea a couple of hours before I exercise which I said around midday say clock because I found I can get some gastric reflux actually if I drink tea right before I exercise but then anyway so then I exercise in the fast state my diet during the six hour time window I eat is what most people would consider a variety of healthy foods bengals fruits lot of nuts yogurt if I eat made it's usually fish occasionally chicken but not so much whole grain side there's a lot of literature out there on whole grains one way and the other in you know there's a there are people are sensitive to gluten and so on but might take on the scientific literature is that whole grains are generally a good for health so you eat whole grains whole grains in Ketosis if you eat whole grains and fruit well I go I go into the hostess in the morning there you go I was hoping you were GonNa say that yeah we'll probably agree to disagree on whole grains for the average person but some people tolerate them really well I know they completely shred other people over time so those are in the suspect Dave thing well I don't know you know so refined grains are not good but the whole grains have a lot of fiber it was good for your gut microbiome at unquestionable and if you look at the actual scientific studies there's epidemiologic Lebanon the whole grains are good even in the blue zones which most of your listeners will be familiar with the regions in the world people unload usually number large number of people live to be a hundred several those areas a lot of the calories are in home grains there's rice in the Okinawa Diet or and so on but are the Okinawans eating white rice or or brown rice white yeah that's what yeah it's not a whole grain they got rid of electons from the outside the fight again well there you go they have a low calorie diet and one thing that hasn't been studied a lot in them as far as I know is well I know no one's measured there key tone levels so oh interesting wouldn't that be fun yeah so it would be interesting in these blue zone people that look you know take blood at different time points throughout twenty for our period with their eating patterns that they're not they're not all eating three meals a day you know space regularly yeah so I think I think whether they're having metabolic switching occuring would be an important thing to know because what we think that's much more important than diet composition except yes except for it's definitely good to avoid simple sugars it's definitely good to avoid a lot of saturated fats but the whole what about fried polyunsaturated fats it we're never in our diet either those seem worse than no yeah the trend trans fats are heated. The stuff that you're French fries are made in America so I I'm I'm what you're saying but I'm a little bit so a near your overall sorta daily thing you're you're eating a moderate amount of carbs it sounds like go go hog wild on the CARBS. You're voting simple sugars in the in the afternoon evening and in the morning you're eating nothing so you can stay in that facet state any we also talk about key towns and because you've developed this metabolic flexibility you when you measure keystones in the morning where are they the the key the key towns strips that you can buy commercially to major ketone levels they're only sensitive down to around three hundred micro molar below that they're you you can't Calcutta and it turns out there's two phases of key tom production that occur so as soon as the glycogen stores in the liver depleted you get an increase from way down long low Mike Grimala levels up to about two three hundred micro molar and they stay up in that level for like between ten the twenty four hours and then there was a second bigger increase in key towns where they go up into the levels and that's over what time frame was the second spike beginning about twenty four hours of of complete faster so Mikey tone levels in the late morning they get up round the two three hundred micro molar level and then actually I haven't measured them after exercise I should yeah but I'm expecting go up getting closer to the one normal level or above during the exercise take a lot of people will find that if they usually kitone strips even after twelve even sixteen hours of passing they made they look and say microphones are up at all but probably they are up it's just below the lower limited detection of those don't strips and if you use your fingers Dick you can get the point one level right now if you're using the key taught the paper strips to major now there's the there's the piece drips and there's the takes trips Are you talking what string either Strip oh interesting even the finger so yeah you have to use other methods that are more sensitive than there are commercially available but they're from scientific they're priced out with their price that that makes that makes a lot of sense I'm in my research and just my own experience I if I do brain octane you know the the one of the four kinds of empty not that that actually after I noticed the difference the studies came out and said that it raises key tones more than other MCAT's or shorter came fats or at least probably Turk acid raises it as much but anyway it's it's the most powerful mgd whatever I put that on my bulletproof coffee I can have a nets for dinner not that I actually don't but many carbs they want more like probably Sushi rice wake up in the morning I can have my coffee and I can get to a point five on a fingers fingers trip yeah right and it it seems there's as in mice there's things that happened with CC can growling at point three point five and those seemed like to me the kind of the magic levels where I don't care about food anymore and good stuff happens metabolic but you're like the godfather of intermittent fasting here so for my I am I am I reading too much into the mice studies in my own experiences there or those special levels or point seven better or like what are the levels well guess what by pointed this by phasing a an initial small relatively small but physical logically and probably health beneficial this lower level like you're talking about point five Muller by the based on the Animal Studies and Human Studies in the time course lew we know that he tones change though those early increases in tones are important for improving health and including improving cognition and suppressing appetite which he to do now you're you're M.'s you're bulletproof MCAT's they're five six carbon LANC not in the six eight hundred unfortunately they might be citing Makita genetically tastes herbal and they're huge gastric irritants so one of the problems with out of empties those aren't adequately filtered out you get a little bit of those or some C. Seventeen and then you get that burning throat or the real strong disaster pants Images to engineer around that and they're really needs a bulletproof so that's not the issue at once was talking about from NCD's yeah the eight and that's later Kuhnen came along and said Oh look four times more ketones than then actually you get from Coconut Oil Yeah Steve China has done some so we did work with the Kito Nestor an animal model of Alzheimer's disease with yeah I read with Richard H e a post doc up to my lab and we did experiments with our mouse model of Alzheimer's and then so we published that in two thousand thirteen and then as she knows Steve Is using Padma Djing positron emission tomography using radio label the cdoe acetate which is one of the two main key Tallinn's elevated during fasting extended exercise the other being weighed hydroxyethyl rate but so he could image he could look at the brains of humans and see how are the brain cells using the key towns for energy or are they using glucose for Energy and he he takes the human these humans puts them on Akita Genyk Diet and they they switch from using glucose key towns attic withink Alzheimer's we know the nerve cells in the brains of Alzheimer's patients the nerve cells that are still alive have they have a big problem using glucose yes bup were pretty sure they can still use ketones you're talking about the neurons specifically yeah in in people with Alzheimer's so if people with Alzheimer's are eating carbohydrates and their K. tones are low and their nerve cells cannot use the glucose berry while and the ketone levels are low enter the nerve cells ATP levels are low however if the Alzheimer's patients can increase their kitone levels in the my sweet models we know that and the humans we think based on the science it's likely that they can still use the key towns so Stephen Steve is involved in the initial stages of a trial of ketone esther in Alzheimer's patients he already gave patients with mild cognitive impairment. MCAT's Oh yeah John Was it your MCAT's are wasn't yes as far as I understand destroy multiple studies but some of his ideas of using specifically are teas but I don't know if that was the study that was using ours right and so she noise already published a paper in patients with mild cognitive impairment which is often a precursor to Alzheimer's that is to say people short term memory problems that are diagnosed with mild of impairment there had increased risk for going onto the ballot Frank Alzheimer's so that's no this is exciting news there's no treatments for embassy I are Alzheimer's we know exercise helps in in MCI patients does not hyper-baric also help him hyperbaric are hypothe- yeah hyperbaric I dunno I think that'd be not a good thing this whole Hormuz idea than so if you Chris Oxygen levels then the antioxidant defense pathways are are toned down like the the NRF2 Pam whereas whereas mild high poxy ah which is which is what occurs during exercise interview Dr Hard to raise the oxygen advantage and it's probably one of the preeminent hyper-baric guys we talked about now I understand that there's sides of the coin but the reason it's interesting is that some of the other training that we do at upgrade labs stuff I have right downstairs is intermittent hypoxia training where you're actually on a on an exercise by breathing air that has no oxygen to drop your blood oxygen down to eighty seven percent Kozel hormetic reaction so your hemoglobin can let go of oxygen more easily late her and it seems like just like with food you're fasting sometimes there's no damn food and sometimes there's only key tones and sometimes there's glucose and it seems maybe for temperatures sometimes it's really hot Minnesota sometimes it's really cold cryotherapy and then for oxygen and sometimes there's no air sometimes there's tons of air it seems like teaching the body to to adapt that serving Ivan Thrive in short-term extremes is a good strategy for living a long time and feeling good yeah you know what one one start had not won we did multiple studies looking at effects of alternative fast thing in rats on heart rate and blood pressure Oh wow would you find it's very dramatic and it's very similar it's very similar to what scene with endurance athletes there with not immediately takes two weeks to a month by then there's very clear the animals on alternate day fasting there resting heart rate and blood pressure decrease their heart rate variability increases which is a very a good thing it's a good thing it's what.

Alzheimer caffeine Frank Alzheimer America MCI Chris Oxygen Minnesota Dr Hard Ivan twenty four hours eighty seven percent sixteen hours two weeks six hour
"mark mattson" Discussed on Bulletproof Radio

Bulletproof Radio

14:39 min | 2 years ago

"mark mattson" Discussed on Bulletproof Radio

"Awesome that's like you should get more of this but okay so I'm going to keep doing that in the morning there's a great question there are lots of studies on mice done with water only fasting and so there are people say oh well they just had waters usually have water but all this stuff I know even like traditional Chinese medicine they at least had tea or coffee or you know Pine Bark Tea or whatever the heck depending on where you're from so I always say Lithuanian men fasting have your coffee heavier t enjoy your life but the purest like oh you know we don't know what it does to your gut bacteria where are you on this some of you should only do what the mice did versus have fun I think it's actually a good idea at least from the standpoint of the brain to drink tea or coffee during a found during the yeah all right and you'd be fine with an herbal tea as well then yeah okay got it and there's all sorts of different herbal teas you can do what about mushrooms medicinal mushroom Kennedy's and people love I don't like Taga very much at all but I I've really gotten some benefits from lions manager the life cycle guys on about that and I just had statements on WHO's the famous mushroom guy is there I love Paul who's you so cool is there anything that you've come across on using mushroom extracts not actually eating because I'd be calories during fast no studies I am interested shrooms I last few years I started foraging I've got Paul's big myself I think I've got it right back there yeah and actually bought some some mice what against Roy stir and Chautauqua my Celia from his company in the spring thing and they're out in the woods ships right now beautiful yeah I'm I'm just starting commercially growing a quarter saps on my farmer and ABC which is really yeah in policy he's from your neck of the woods he's One island over he came here for the interviews tastic sounds like you guys know each other I don't know but you know and but fascinating chemicals in mushrooms lot more work needs to be done there are there are some reasonable studies with things like Turkey tail tea and some of the things Paul talked about but on the other hand scenario whether there's a big need for a lot of better science yes as you know finally they're starting to do studies now with hallucinogenic mushrooms one of the scientists that Hopkins in fact has shown a couple of published studies now that the suicide mushrooms are beneficial and people with depression and you know and they're not addicted Kahad in contrast to the opioids right which is a huge problem these chemicals and mushrooms that seemed to have some interesting effects on the nervous system are not addictive which would seem to be a big advantage it seems nonsensical that alcohol Yeah Cotin and the opiates are legal and caused a lot of harm but I don't know anyone could be really addicted to the strong hallucinogens. There are people disassociate because they're so traumatized her diction that's that's just deep seated trauma response which is a different animal at least that's my wife says so she's a let's get trained drug and alcohol addiction emergency doctors I'm going to believe her there which is there are people who abuse them but they're not addicted versus actual addiction I'm all right I'm I'm really interested in compounds that I know that you're interested in nerve growth factor in Jeff and beady enough brain derived neutral big factor in I I wrote about those headstrong and I've used Y- There's old studies on mushrooms there's a compound he's one of my supplements from the fruit of coffee a polyphenol that raises BBN F- coffee itself probably does according to some other research fasting I believe raises Jeff can you walk through your perspective on increasing nerve growth factor and brander avenue trump's or factor what do you believe works and how important is it for living a long time with a good brain now both be DNS and NGOs F- Are Important for the development of the nervous system for the survival growth synapse formation and then the fine tuning of the structure of the brain during development if you eliminate the genes of either NGOs or beat enough from mice they died during development so that are critical in the adult brain Beat enough is particularly important throughout the brain all over the brain in promoting the growth survival of neurons it's critical for learning and memory and it's so we we shot in my lab when I was back at the University of Kentucky in the early nineteen nineties that beat enough protects nerve cells against various types of stress oxidative stress metabolic stress something we call excited toxic stress which is unconstrained neural network activity like occurs dramatically apple APP see but we think too unless dramatic extent in brain aging and Alzheimer's Disease So Ngo off on the other hand there are only a small but important group of brain cells let responsive enough in the adult brain Exercise is is a potent stimulator of bef production in the brain intermittent fasting stimulates obedient up production and the combination of exercise in fasting get an added of boosting bedia now fan I had a graduate student laxest Granahan who showed that many years ago in studies where she combined running we'll exercise and daily time restricted feeding Komo daily short fast and found she got a additive effect increasing beady analysis than actually protecting synapses against diabetes which is kind of another angle on this it turns out that obesity diabetes are not only bad for your heart there are bad for your brain yeah particularly should get as you get older and we think that intermittent fasting well actually no it intermittent fasting exercise can reverse diabetes obesity in humans if a person can switch they're eating Saturn get on an exercise program and beady enough plays a role in that so in individuals who are obese or or diabetic beat enough levels are lower in their brains compared to normal weight folically healthy people one of the things that that really changed my life when I weighed three hundred pounds announced having all kinds of cognitive dysfunction my my twenties and early thirties I started using a thing they called the Russian sleep machine through electrical stimulation with alternating current between the very different than the TD's now and it turns out there are studies that show both td's yes and CBS or alternating current raise beady enough very meaningfully yeah I'd go to sleep with this thing and I swear my brain health to turn back on and now at forty years is in the brain upgrade place that I started we use a clinical grade you neuroscience level system that lets you have specific frequencies that are tuned controllable by a computer and we do that to prime the brain for for better learning of altered states that you learn through feedback and e you go all the way down to Halo who's been on the show who makes td's headset when I do exercise I Especially lately I can't I can't keep up very well with my nine year old at Ping Pong can ping pong is a high reaction time thing keeps your brain young Dr Ayman told me to buy the ping pong table. I did so I started all right I need some obedient up here like my my son's kicking my butt and you've got the program carbon-fiber paddles and we're going at it like he's good did you that run bad but I was not a it's not a good competitor for him so I started running the electric earn over my brain again the halo and also my learning went up in twenty minutes after doing it it's like the ball slows down and I hit it and so so I believe that's a beating of sort of thing but if you seen electrical stimulation magnets lights of going to the bottom of swimming pools. I don't know any other crazy tech like that that's GonNa make our brains more plastic that the answer is yes and at first I want to go back to when you're young and obese right and he did this alternating current stimulation in your brain did your did that reduce your Appetite the reason I ask is it turns out that beat enough suppresses appetite interesting this is I don't think it did I'm just I'm going back to all the different times I'd use it out oftentimes use it when I was sleeping or like when I wanted to write even when I was writing all my books that there are times when I change the frequency on my device to go up into the game arranges but did it help you lose weight it could have I feel like the thing that really helped me lose weight was getting rid of the inflammatory foods you know things that were inhibiting andro function was the number one thing but it could have had an impact but for me it was wide twenty two ketosis and then I came out of Ketosis and I went in and out in that got half my weight down and then the other half was oh hey guess what certain foods are GonNa make inflamed no matter what so you gotta change the type of fat that makes you going to get rid of the shades if you're sensitive like I am and that was the genesis of the whole bulletproof diet approach was these foods may or may not be good for you but don't assume they're all good because if you're still fat after you tried hard for so for me it was finding a guilty suspects so let's get back to stimulation and beating F. B. didn't have was discovered an animal model of epileptic seizures and there was a lab on California though was this kind of looking for jeans better respond it's a seizures and beat enough is highly responsive so as you know one the treatments for depression which is still using people who don't respond well to anti-depressant drugs is electro convulsive shock therapy eight and it's highly antidepressant and it's highly potent in inducing beady enough expression wow I didn't know that also the the antidepressant drugs themselves a Serotonin and norepinephrine reuptake inhibitors prozac pacts Etcetera Day Razer beat enough levels in the brain and an animal studies if you if you web ways we can genetically manipulate the mice Oh that they can't respond Abedian those mice do not show an antidepressant response to those drugs so together the bailable evidence says beat enough is is an it's an antidepressant and dodge antidepressant you mentioned it's totally up regulated by exercise exercise is a really good the antidepressant and in fact they're made the people who exercise regularly and then have some injury and they stop exercising that often precipitated episode of depression because they've been going along exercising and all of a sudden I believe they're beating F- levels are going down so anyway there is some evidence that even low direct current stimulation are trans cranial magnetic stimulation can increase beat enough levels yeah caffeine caffeine will increase median of levels there you go I'm I'm intrigued about what you do to manage your beating levels and I just WanNa four just warn everyone look you're an expert on aging but you're also the age you are in your mail and you have your genetic and lifestyle factors that we all have Oh this isn't a do what you do but I want to know what you do specifically forbidden to keep yourself strong and those things and then I wonder why you do it so what's your personal practice from engine those given measure them while that's a problem because wait I did we'd have to measure men the brain or at least three three rows file fluid so it turns out that there is big enough and Jeff in the blood but the levels of those tropic factors in the allowed an animal studies are not well correlated with levels in the brain turns out that nerve cells are not the only cells that produce.

three hundred pounds twenty minutes forty years nine year
"mark mattson" Discussed on Bulletproof Radio

Bulletproof Radio

27:49 min | 2 years ago

"mark mattson" Discussed on Bulletproof Radio

"Is in there in the plants volusia reason is that they are noxious agents their toxins and and caffeine's a good example if you take care caps go up so fast thing you know by definition if you're in a fasted mutagenic Peter Jennings state that's a sufficient time it was not eating to be designated as fasting if you're K. towns never go up you haven't Hit a fast lasting state okay what do you do even studying this stuff for a long time what what are you doing you wake up in the morning like what's a typical day for you with a typical week I never eat breakfast and I usually try to workout midday early afternoon the run a lot do a Lotta trail running at some knee osteoarthritis because I had a meniscus tear probably but so now I'm mountain biking maybe two or three days a week I'm on the trails on mountain bike the other days I usually do some walking or stationary bike but I pretty much always do that before I ate around midday early afternoon and then eat all my food within a usually a six hour time window sometimes five hours so that the rationale for exercising at the end of the fasting it is pretty simple you get an extra boost in the ketogenic state but there's also a number of we call pathways or signaling mechanisms that are activated by exercise both exercise in I think they get amplification of those pathways is door you're talking about well yeah that's one so and autophagy okay some of my favorite words can you define them for people who don't know what they are immature and autophagy okay and and this again relates to the notion of metabolic switch from glucose the key towns and what happens then so when your glucose levels are high normal or particularly after eating a meal There's a pathway called the M. Tour Pathway in cells that activated and that pathway stimulates the uptake of glucose it also stimulates the uptake of Amino acids from proteins in your diet and then the sells increase their protein synthesis and they're in kind of a growth st however while they're in the girls state they are also accumulating molecular garbage so when cells are growth state and your your calls protein levels are up in your blood can help the cells grow but if that stays chronically on there's accumulation of molecules damaged by free radicals dysfunctional might account those those damage molecules are normally removed the cells by a process called ATAF sales garbage disposal in fact we just had a recent interview on Metabolic autophagy that was very well received and I it's a very important thing like getting rid of the garbage and you're saying that if you do an intermittent fast and then exercise at the end of it you're going to turn up autophagy and you'RE GONNA turn up tour which allows you to take amino acids and put it into the cells or no because those Zongo the I'm right also that go up so the during the fasting and exercise pathways inhibited the cells the cells go into a stress Resistance Moat and they're trying to conserve energy molecules recycle proteins so it's garbage disposal but it's also a recycling bin so you can incinerate garbage to make energy to make energy but also to to to break down damaged proteins but then take the amino acids from those proteins that are not damaged and use them to make new proteins okay and you get this from fasting and exercise both and when you combine them you get a further enhancement of the autopsy goes then then when you eat and rest then what happens is the cells have cleaned out the garbage and then when you eat and rest the tour pathway is active themselves synthesize a lot of new proteins they can grow for example your muscle cells when you exercise regularly your muscle cells don't get bigger during the exercise get physically bigger during the rest period but since about recovery right but if you if you don't exercise the sales never get signals that enhance their ability to grow when you do rest so riley cycles of metabolic I challenge recovery challenge recovery and the challenge is being fasting and exercise and then eating and resting sleeping is very important those intermittent challenges we think can optimize health but here's another question and you may have gone into this and some of your research I lived in I haven't read all of it I when I wrote the bulletproof Diet I was looking for things that would suppress MT or so it would be bounced back more strongly in the three things I found were certainly exercise we just talked about fasting which talked about but there's also studies on coffee an tour have you looked at the effect of coffee on either autophagy or door we haven't and it's a good question that I don't know the answer to there's there's a lot of excitement for a guy exactly drug development standpoint and Rapamycin and I'm sure you've heard about that yes but that's a little bit scary of because you can inhibit m toward too much nephew inhibited too much too long that's not good either so again you know these cycles of as far as caffeine goes my opinion is good for your cells but probably not if you have caffeine levels high twenty four seven yeah that whole sleeping I think what most people do than drinking coffee or tea in the morning while fasting is a good idea caffeine certainly boasts your alertness in enhances your cognition educator that's right cranes work at UC San Diego showed kitone Booze Yup okay so I think caffeine's good we I published an article in scientific and American in two thousand fifteen and the whole take home message of the article was that many of the chemicals that are in vegetables tea coffee plants that are good for health the actual reason they're in the plants evolutionary season is that they are noxious agents they're toxins right and caffeine's a good example if you take pure caffeine and on your tongue you would wanna eat it's very bitter tasting and caffeine's a natural pesticide produced by coffee beans can t leaves and if you take coffee beans or tea leaves and put him on your counter and put most any food next to it and there's ans- in your house the ants will avoid the coffee beans and the tea and they'll go for the other the things that don't have the bitter tasting chemicals in it it's fascinating nicotine's that way too I mean caffeine to the smartest drugs from nature that increase human cognitive performance and they are both killed bugs which doesn't mean they're bad for us both a nicotine in high doses from what what's interesting here Dave is that some of those chemicals activate the exact same responses in cells that are activated by fasting and experts doc and one of those one of those pathways which I'm sure you reported of is the NRF2 A. R. E. Pathway it's for example there's a chemical sulfur thing that president high levels and Broccoli sprouts green leafy veggies both and but the key thing of this pathway is it's an antioxidant defense pathway so when this Up to a R E pathways activated by exercise fasting some chemicals in plants than sales boost their intrinsic antioxidant defenses and are more resistant to being damaged by free radicals and this is this is really why the trials will like vitamin E. E. Vitamin A vitamin C and a lot of different diseases cancers cetera pretty much uniformly failed what you don't you don't want to swap yourselves continuously with the chemicals at scavenge free radicals because then pathway such as enter to pathway or never activated. Yeah because they're activated by the stress of the fast thing they exercisers that Kim it's interesting that free radicals themselves are signaling molecules in an interview doctor Oh Jeez Dr Rohan and then later how can you blink his name that's early stranger must need more key towns whose names that often a tip of my brain anyhow one of the preeminent ozone therapy guys looked at the ability of the free radicals from ozone as a signaling molecule to trigger my toe cadre repair not from Breathing Ozone but from other medical uses of it even just topical on the skin and things like that and it's it's really interesting if you take those accidents you talked about before exercise you don't get the benefit the exercise what about during passing I mean should this be when you're when you're in fastest date don't take your vitamin E. No as far as I know and ah I know this field pretty well no one's done those experiments with fasting that's only with exercise okay somebody listening is and do those experiments because all the right people are listening at least I'm going to tell myself that so this is a fascinating thing you want you if you're working on your hd you're trying to figure out what to do you're going to go to school seriously investigate this just do fasted mice or whatever animals you like working with or humans my favorite guinea pigs and see what happens if you fast and just look at all the different markers metabolism may be urine organic acids and see what happens if someone takes a fistful of vitamin E. Vitamin C.. Even good if I on which is a huge fan of during versus after a fast versus after exercise we already know what does exercise but if fasting and exercise kinda mimics of each other I'll bet you that you should take care antioxidants a while after the fast not during the fast or maybe the beginning but somebody told me the answer so I can read about it and they can do it if you had to bet what the answer be what would you bet better be similar to exercise Yeah Okay Yeah interesting I've never thought of this before but I I would agree with you that I'd place my bad in that same spot that said all right let's let's look at that now would you consider the Paul there's many different polyphenyls boat but I mean I make a polyphenol blend there's chocolate females there's coffee polyphenyls there's Oregano and you know pretty much any kind of flavorful vegetable fruit kind of thing or herb especially would you look at avoiding those during intermittent fast or would you consider those to be useful during intimate fast those they they the notch just the bitter tasting ones are probably useful. Yeah Yeah I think so too I don't know any just police off the top of my head they're all pretty pretty nasty tasting other than it turns out people who are fast caffeine metabolites.

caffeine Peter Jennings Kim Dr Rohan Paul five hours three days six hour
"mark mattson" Discussed on Bulletproof Radio

Bulletproof Radio

11:55 min | 2 years ago

"mark mattson" Discussed on Bulletproof Radio

"Bottle one per household limit lease is valid while supplies last act of the day is that there are different days to kick-start intermittent fasting so it's easier for you if you don't know bannerman passing this is something I wrote about in the bulletproof diets may have been doing for a very long time I'm and basically you eat the same amount of calories you're going to get you just eat them in a smaller eating window each day basically have just lunch and dinner skip breakfast or have there's lunch and breakfast dinner it's pretty straightforward you wanna eaten about six or eight hours so here are a few different options that are out there for you there's this one is fasting for twelve hours a day and there's studies reader these things there's no one fasting for sixteen hours and interestingly in and that study men fasted for sixteen hours and women fasted for fourteen hours because this is gonNA sound really really bad but men and women are actually different biologically I know that shocking for some of us however fasting can be harder on women and I've seen this over and over since I started the bulletproof blog where the rules are different and there's a couple really popular posts about you know why intermittent fasting can be bad for women that I've written over the time there's also fasting two days a week is called the five to diet there's alternate day fasting where you fast every other day or have limited calories every other day there's one weekly twenty-five fast known as he'd stop eat and people just give an occasional meal and then there's this mad or the warrior diet which is twenty hour fasting window with a huge it meal at night a steak and whatnot and you could do the same thing with a huge meal in the morning if you really WanNa carry around you know steak eggs and whatever else reading all day long that might have some circadian benefits so online is six hours or size six meals a day so your body isn't going to starvation mode it is absolute bullshit it is a way to feel crappy and probably stay fat at least that's what happened to me on something like that and that's not say you couldn't do that sometimes Times especially if you're working out a lot but if you WANNA do that on a regular basis as a regular human being you might not like the results of that but the number of processed foods snacks you eat may go up dramatically if you do that. A today's guest is the foremost scientific researcher on the topic of intermittent fasting guy that I'm really really excited to talk with because there's so much academic research that goes back quite a while now about what intermittent fasting does but it's one of these precious pieces of knowledge that hasn't entered our consciousness where it sort of it has been fringe knowledge and it's just now becoming something that not just bio hackers do but your mom might do in fact my mom does do it and it makes a really big difference so not only is today's guest top expert on what intermittent fasting does for you it he's also an expert on what it does for your brain and he's one of the the foremost researchers looking at cellular and molecular mechanisms of neurodegeneration like Alzheimer's and Parkinson's if you're only headstrong I actually referenced some of his work in that book I'm talking about Dr Mark Manson who's a professor of neuroscience at Johns Hopkins Welcome to the show Mark thanks Dave I'm looking forward to talking to you followed your bulletproof website for a long time and when I can listen to your odd cast which are always both informative and entertaining so I'm looking forward to our discussion wow well thank you I did not know that until we just got on you mentioned that so I am truly honored because I mean in addition to the Inter I just gave you I mean you are chief of the laboratory of neuroscientists national institute on Aging least you were until you just retired last month so in terms of the anti-ageing world that I live in your sort of a godfather of that so the fact you've ever heard this show is epic thank you yeah well you know there's a big one of the big bottlenecks in getting science Translated into the real world is communicating to the public and there's many science China's flat either avoid intentionally are just don't WanNa bother with taking the time to learn how to communicate with the general public so you know outlets like yours which really are evidence base and communicate things in a way people can understand I think our our value so you know I do and these podcast easy to listen to I can even be do you know working on a manuscript well I've got a podcast in the background so yeah I I do find time to listen okay that's really cool I I'm going to go there there are not a lot of people here who can listen to one thing and right another thing have you always had that super power I don't know if it's a soup I think it started by you know I'm a NPR nerd. So I'll I'll have and I tell her even when I was lab chief than I h One sometimes two days a week and I just have we are on in the background and kind of tune in and out there's place certain points when one writes that you can kind of relax a little you know what you don't have to concentrate so much and yeah so I've learned to do that one of my my buddies real dynamic guy named drew and I'm not going to drop his last name because I think he kinda likes to hide behind the behind the curtains but he's I had dinner at his house and wrote about it in Game Changers and he knows in his home talking about Entrepreneur friend he told me that years ago he started using Bluetooth headphones before they had the Bluetooth Standard done and he listened audiobooks twenty four hours a day like all the the nonfiction stuff just to learn things and he finally said after two years of it my brain just started learning when I wasn't paying attention but he stop worrying about losing something and just assume some of it's going in I haven't gotten to that level yet but I have been able to listen to one thing and right on my latest book but not the whole time sometimes I would but the load on my brain felt pretty high do you feel more loaded if you listen to podcasts and writing management I'm fascinated by this I wasn't getting to know so Oh you know I'll I'll pause are turn off the volume on one I'm listening to when I get to where I have to really think like ten twelve twenty administrator are that that's a neat little technique I think most people listening going Oh my God it's possible to write and listen anyway that's a new skill for me so all right you also talked about the difficulty of translating scientific academia into public knowledge and I think some of my scientists friends are a little bit frustrated this thing I like you know I've spent my life doing all this crazy work but no one knows about it and so they're they're kind of feeling like I did my part art but you've done something interesting in academia in for research there's an index so productivity in citation impact so you're index is over two hundred which inactivated means you're Super Rockstar gold record label and it it's a pretty pretty good number it's based on your toll career so also means I'm getting old okay that's a fair point but you've been cited one hundred fifty thousand times your work has been cited so your Europe there right but at the same time you have three and a half million Ted views on your talk about intermittent fasting so you've crossed uncalled crossing the chasm to butcher that term into all right you can now talk to the public about intermittent fasting and reach large numbers and if you've talked to the academic and nutrition research on neuro science world what was the trick for you as a macabre hardcore aging neuroscience guys into crossover and talk to the public while talking talking to friends and even students in the lab I'm trying to learn to explain things initially in a very easy way and then by looking at their facial expressions you can tell whether they're understanding or not and if they're not back off and and give some analogy or out take a little different pathways to try to help them understand what I'm trying to convey so I think it's just a matter of doing it practice practice yeah okay and do something you set out to do was this goal you said or just emerged over time it just emerged yeah okay oh although now that I'm retired from Noaa semi-retired I'm still gonna I'm still involved with working with clinicians at Hopkins doing trials of intermittent fasting in various patient populations and I'm writing a book finally to books I actually the first is GonNa be you kind of with an intermittent fasting famous historical perspective than allowed hardcore science hopefully explained a way people can understand and the second books GonNa be here neuroscience which is what I'm really excited about it's GonNa be something like that doc pattern sowed the brain understands and escapes reality that which is that is gonna be fascinating in fact when you write that book we'll have yawn a big part of my understanding of the world is really it's the challenge of not believing your own stories going on including around food the story and your head is if I don't have I'm going to die and it's probably not really true okay we wouldn't be we wouldn't be here would we exactly but it sure feels true at the time and that's the challenge of fasting in in a nutshell is is how do you how do you feel good when you do that well let's let's get in on on fasting and just go in for people who are we've heard about fasting you have pictures of you people in robes fasting for days on end and things like that talk to me about the difference between calorie restriction and actual fasting and what you've learned about that over the course of your career the differences have to do with the frequency of food intake typical human liver can store about seven hundred calories worth glucose in the form of glycogen and if you're just kind of moderate activity Are Like we are now takes ten twelve hours to use up those seven hundred calories and then when those calories go then you start using fats fatty acids are released than those are the precursors of the key tones and so it's possible to reduce your daily calorie intake but eat as you mentioned in your introduction eat meals frequently every time you eat Amelia Replenish glucose stores in your liver and so your fats are never mobilized your key tones never.

Dr Mark Manson bannerman China Johns Hopkins neurodegeneration researcher institute on Aging Parkinson Alzheimer professor NPR Dave seven hundred calories sixteen hours two days twenty four hours ten twelve hours fourteen hours twelve hours eight hours
"mark mattson" Discussed on Bulletproof Radio

Bulletproof Radio

02:21 min | 2 years ago

"mark mattson" Discussed on Bulletproof Radio

"And if you take coffee beans or tea leaves and put them on your counter put most any food next to it and there's aunts in your house hi of the most patented any talk about p three Oh am because I'm an actual customer and that's why I'm pretty excited that got the guys that biopsy misers to give you a free bottle today what makes us train differ what is that it's means it actually eats protein it's also got some antiviral antiretroviral properties which pretty cool and it's designed to get rid of pathogens your gut and also can enhance fat loss and can improve your digestion and stuff like that but it's very unusual approach to probiotics the crazy part of my friends at optimize are just going to give you a free bottle no tricks no force continuity nothing slimy because I wouldn't let that happen and they're giving you a three hundred sixty five day money back guarantee go to pete three Om dot com slash Dave free that's P. Three OEM dot com slash Dave free all one word you'll automatically get access to your neat coupon code to claim your free.

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"mark mattson" Discussed on Sports Talk 1050 WTKA

Sports Talk 1050 WTKA

04:30 min | 2 years ago

"mark mattson" Discussed on Sports Talk 1050 WTKA

"School counselor had Travis Knight. Mike chiropractor had Mark Mattson? Lebron? What's that scrub? Brought me nothing. Man. Gimme my freaking rings peace out. Let's go home and watch ourselves on the news. God that was embarrassing. Back to the phones it is officially smack off season. This guy has a standing invite to any smack off. He wants to be a part of. No, he is not want it. But he's that good right to the front of the line Mark in Boston. Mark. What's going on, man? How are you? No time for Rick. Absolutely, right, man. The odds are off. High on the list quantity has never been better than quality, dude. Ask the Canadians Jimmy. I gotta hit on John beeline super bomb to hear the coaches moving on to the NBA. I mean, it would be really bad. If like someone had a tattoo of the guy on his arm or something that would be really embarrassing, but HBO way to get one of the most remarkable and wanted figures for a cameo and have it land fled on face. No. I'm not talking about left blowing up that absolute layup. Larry Brown talking about blowing up literally Aaron Rodgers on game of thrones good job guys. Speaking of the odds, Jim. Stick out. I in Green Bay has the third highest us to win it plus five hundred very nice, Steve if you're gonna make a joke about the wait at least make it accurate, plus three twenty five or something. Carla's in the field. World we ever compete in a contest where you need a fake tough guy voice role play. And even though the winner is predetermined, Brad. Speaking of Brad, good, bro. You're really going to get along. With brad. You both shave your entire body. Slip into barely fitting underwear have dudes all over you. My point is Carl you're gonna do just fine. We may not have macho man Randy savage, but we do have Nacho man Caleb in Green Bay aka the Bunder taker but that guy's never wrestling life. So no worries there we don't have do in the field name Dirac. But we've got a guy like new from Arkansas that looks like he's smokes them. We do have a couple of good brothers. Those two losers Tolleson. I mean, they haven't been relevant twenty years, but neither is the WWE. So digress. Jim every wrestler has finishing move. So I'm gonna go RSVP here. GM you can officially count me in for the snack off Jimi. Let me tell you something on June twenty twenty-first get into a cage. You hear that? You hear that? Midwest mafia, all you clowns down. You do it rack alvie. Mark im-, Boston savage. A love that RSVP not every part of that RSVP some that could have got him running probably should have except we know where he will be the day the smack off. He could win it. You gotta be in it to win it. And he's in it. He's talking about the odds. Stuck out the odds? I've got thoughts on the odds as well. Taking a run at my man. The good, bro. The good, brother. I don't need to stick up. The good, brother. He can handle was owned business. We know this. NPR says back news back again. I don't know what Laker fans complaining about. I've brought championships to the Lakers. Regards Dwight season news. Anything different. Right. And I'm still NFL hall of Famer, and I'm not lame. But he tell me any different. So I'm walking around on my muster jacket. Well, I'm in the hall of fame Rome, you've never played football. Luckily, nobody told me any different I'm in the hall of fame asked white. No matter how career ends no matter that I've never played football. I I'm still in the NFL hall of fame. Jamie. Green Bay tweets the clipper broS were way, cooler than these Laker broS turn-up. Love you guys. Awesome way. Cooler just like the clipper organization is way better than the Laker organization right now..

Brad Green Bay Boston Jim hall of fame Rome NFL Mark Mattson football Lebron Jimi Randy savage Mark Mike chiropractor School counselor Travis Knight clipper broS Aaron Rodgers Mark im Carl