35 Burst results for "Lupus"
The Case of Sandy Melgar
"Ever heard of this case. I've heard of it. I knew it was on truth and justice. But i don't know the details at all so this is going to be like you're going to be revealing this to me as we go. Let's do it so we have hymie melgar. Who often goes by jim. And that's how we'll be referring to him in this episode. He was born in guatemala and had immigrated to the us when he was just three years old and he lived in texas with his parents and his two older brothers by all accounts. Jim was very smart. Well liked by really everybody. He was described as having a great sense of humor. Living a very healthy lifestyle. He was very active and very helpful to all those around him. And then we have. Sandra known as sandy which will refer to her. Sandy also lived in houston and that's where her gym met back in. Nineteen seventy seven when they sat next to each other in high school classroom. How does that high school sweetheart. They are high school sweethearts. He wanted very cute. He actually sat behind her in class and apparently he was smitten with her in houston. Pull her hair. Oh as an acute so few years after high school in one thousand nine hundred eighty two got married and they started their life together. Jim started his career as an it. Specialist and sandy nurse later they would start a medical billing company together and they worked quite closely with each other and they also managed a few rental homes. The couple had one daughter named liz who was born in one thousand nine hundred five around. The time that their daughter was born to the couple became involved with jehovah witnesses. That's why sorry. That's why i also remember this case. Because she was they. Were jehovah's witnesses yeah. The melgar 's allegedly wanted to provide a strong religious upbringing further daughter. And that's why they had sought out a religion at this time. The family was very close. Knit very happy. According to their daughter there was never any yelling never any disrespect as she would say they were an example of a perfect marriage over like families they did have a few obstacles. It was really sandy's health. That was the problem. Sandy suffered for many many medical ailments. She had lupus epilepsy hypothyroidism. she had double hip replacement. She had short term memory loss. She had bouts of vertigo. She also suffered from multiple violent seizures in which she would experience retrograde amnesia
Molecular Therapeutics Hopes to Reshape Gene Therapy
"So the first rail on a touch on today is from arena pharmaceuticals. The ticker symbol is a u. p. h. And they're sitting in a market cap. Now veron two two point one billion dollars and what we heard about a week ago is that they received fda approval for luke kindness for adult patients with active lupus nephritis and for those who haven't been following the company too long. They showed really really powerful phase three data. The stock shot up really well and then it's been kind of slowly selling off into you know around the thirteen fourteen dollar area and what we heard with this. Fda approval is the stock shot up to around twenty bucks and since then it's trading at around sixteen dollars now. I took a position around thirteen bucks and then sold most of it at around eighteen. And now i'm just sitting at around ten shares in anticipation of the future. And so we'll talk about that right now. But basically what the fda approval there are few details and one was that there was a black box warning but it was pretty much in line with cyclosporine. So it's not really anything to be concerned about. The other real benefit is that the patent protection is likely until the year twenty thirty seven so there were some concerns that the patent protection for arena in this drug was not gonna last that long and that could cut into the profits given the fact that they would lose exclusivity after a while so the other thing we heard is that arrhenius set the pricing and they said it at a price of three thousand nine hundred and fifty dollars for sixty capsules and then they estimate that the net revenue per patient per year is gonna sit at around sixty five thousand dollars so i did some quick math. Here to look at the prevalence of lupus and in general has around twenty to one hundred fifty cases per one hundred thousand people so in the united states that works out to around sixty six thousand two four hundred ninety thousand in the usa. And i know that's a pretty broad range but these are the These the publicly available stats. The corporate presentation of iranian says. That around forty percent of lupus patients have lupus nephritis so the actual problems in the kidneys that would benefit from this therapy so that brings us down to around twenty six thousand one hundred ninety eight thousand total addressable patients in the usa. So we have. Here's an estimated total potential revenue between one point seven billion to twelve point eight billion now again. That's a. It's a huge range. When there's an order of magnitude in there but at least there we get a sense of the kind of revenue. The company is going to be able to bring in sitting at around a two billion dollar market cap. It's definitely on the lower end. Even though this is the total addressable market and we know that arena isn't gonna be able to penetrate the whole thing. But i think the reason why the stock is of depressed is because of the bear narrative in regards to launch concerns so often with these smaller companies. Because they don't have an established salesforce they don't have necessarily those established relationships with either. Kol's or doctors space. It's difficult for companies that are small to really ramp up and deliver when it comes to the sales numbers so the bare narrative is saying that well they're going to really struggle with the launch therefore the company should only be expected to do the lower end of their expectation. Now on the both side. They're saying that well arena could be an emanate contender. And there's reasons to suggest that given that the risk is so low with this drug now. The data looks good and it's already fda approved so they could be being looked at by larger pharmaceutical companies. Who already have those established sales and marketing pipelines to just include this into their portfolio products. And start selling it so. I'm not sure what's going to happen. I'm going to relatively small position. I don't know how much i feel like diving in here. Given the the launch is going to be complicated. But i could miss out on a a merger acquisition deal. That could come as well. So that's really i think. Obviously it's very positive for the company and very positive for patients that are suffering with lupus nephritis but for me. I'm happy with my small position and just seeing what happens with the start with that. Let's move onto rhythm pharmaceuticals ticker symbol are ytm and they're sitting at a market cap of around one point three billion dollars and what they announced. It was positive data from semolina tied in additional emcee for our pathway deficient related. obesity 's so semolina tied was recently approved for hamas egas recessive mutant obese conditions related to pompey pcs k. One and leptin receptor so what that means. Is that patients that for this need to have a knockout in or a mutation in both copies of the gene whether it's policy pcs k. One or leptin receptor. Now what we weren't sure of is whether or not similan tide had an effect in hetero zayas patients and what this is is patients that have one functional copy of this gene so if their drugs sent. Milan could have an effect. In hetero zygote significantly expand the patient population that would qualify for treatment with this drug and with an expanded patient population. Obviously the revenues could be substantially higher than what we expect if it was only the home. Zygote
Apple, Facebook, Tesla Earnings: What We Learned
"To help us break down. The results are tech. Columnist diane gallagher. Hey dan thanks for being here be here so before we get into the nitty gritty kind of trends and challenges that define two thousand twenty companies and this past quarter in particular. And why are these results so significant. Well i think obviously when people are without jobs and drop an income that that you think that would take down the market for these kind of companies and what we're seeing though is with these with these really big tech companies. They're scale actually helps them do better in these times because they have they have so much market and they're also selling especially apple is selling things that people need in some cases need even more so. We saw big explosion of ipad sales for instance. And that's more students who are stuck at home. Do an online learning more people stuck at home. Doing work is actually driving sales. And things like pc's and tablets that weren't particularly growing a lot before the pandemic. I think some of the changes were seen in consumer behavior or kind of temporary because of this moment. And then some you know and then so maybe longer lasting you know. I think people are gonna probably be working from home more than they did before especially over the next couple of years. They'll still need equipment and services geared to that the sleep batch reports brings to in particular that what are very interesting against the backdrop of the pandemic. that's been so crippling economically in hit too many jobs and incomes apple. Tesla sell very expensive things you know at the top of their. You know tesla's probably among the more expensive cars you can buy to the classic cars that competes with you know iphones macs all. These devices are among the most expensive in their class and both companies reported a really good december. Quarter tesla swung into profitability apple. Had this record for apple sales past one hundred billion dollars for the first time ever lupus wall. Street's estimates iphone sales are really strong profits. Were record as well and so it. Really contrasts sharply with what is actually pretty dreary period for the for the entire global economy. And of course the other big issue we saw was supply chain disruptions especially early on. Is that still play here. We'll sure we saw especially on with apple because they make all their stuff in china. So and that's that's the pandemic started and so early early in early. Two thousand and twenty you know. These factories closed down. They saw a big productive hit to their production but obviously in china things recovered before they have here. So they've been able to get that back going. I you know they've essentially just smooth it out. I mean a lot of hits. They saw that way. Were were temporary. You know we've seen other issues where shortage of things like chips. The are used in cars and other factors in that has the and that's really affected pretty much companies across the board. So it's actually a great question this battery reports. Maybe even could have been even better. Had we not had those component shortages. Yeah and that's a good point breast to dive into the results themselves. And i want start with tesla early in the pandemic tesla ceo elon. Musk differentiated his company from other tech companies. You know where you can make software remotely. You'd have factories opened in order to make and deliver electric vehicles but despite that challenge tesla ended up having pretty great year. So what did we see from them this year and in these results as well yeah. We saw The delivered nearly half a million vehicles in two thousand twenty and there are actually they can now increase that by about fifty percent in the coming year and again we saw the it was her first year. I think of actually reporting profits and this is a company where the stock has been doing phenomenally. You know investors are kind of have been chewing the company on even when it has you know challenges with its business or you know spend a lot more but i think this a quarter in which this particular quarter is probably gonna help. Those have been like betting. Big on the on tesla wall street got it so the first full year profit but but still a lot of cost associated with those supply chain issues that we talked about earlier. Which weighed things down a little. You know. speaking of supply chain issues apple was also hit with them similar problems which ended up delaying the release of its new lineup of iphones. That included its first. Five g capable the benefactor results it affected but you. You almost wouldn't know it by looking at what they what they've reported this record period. The iphone launched about a month later than they normally did kind of broken apart. Their big selling point was five. G and five. G has been something that you know quite honestly you know the services are kind of hard to find still but they made these phones very attractive in their own right. A new design powerful cameras And so they. They did really well on that. We don't know apple doesn't say. How many sold anymore. They don't give unit sales anymore. But the iphone business had its best period of revenue growth in more than two years and registered record revenue for that particular business so it did really well even with the kind of leader module we saw and of course apple offers a ton of other products and services. And they've actually been pushing into services even more recently. Had that part of its business. Do that did very well. This is actually accelerated. The growth was above twenty percent in this last quarter had been kind of skating along mid teens. You know from last several in the. That's something that they've been. They've been putting a lot into that. You know there they now have a streaming tv service. They have a fitness type service that we compete with companies like pelivan a little bit. They're putting more into music and games And for them. This is important because not only not only kind of spreads out their their business diversity in they're not relying so much on hardware sales but services carry much higher profit margins and we saw that this was this was the highest profit margins. They've reported in more than five years that they reported for the december quarter so clearly paying off for them and just finally. We also heard from facebook yesterday. And unlike these other companies facebook's products are completely digital social media advertising. It seems like that would be a benefit as remote. Communications really became our only way of communicating in the past year. It was and it was. It was a good period for them to they continued add users. They they're ad. Revenue exceeded their growth their exceeded wall street's expectations facebook. You know there are always a bit cautious when they look ahead. They're warning about things like some of these changes apple is putting into its operating system. I make it harder to track do attraction for users and they've been talking about that for a while but the you know the business even with all the all the problems. Facebook has had in terms of its public image. Privacy politics this is essentially an advertising machine that continues to just print money every quarter. You mentioned those challenges and there have been some pretty big ones for facebook especially on the regulatory front. What have they been facing. And what kind of impact that had. Well i mean they're they're facing you know like by some of the other. Big tech companies are facing serious questions about the power they have as a platform and whether they have too much. Whether they're too big. I think they're probably at the forefront google are facing actual like lawsuits and pressure. There's people in the government that think. Facebook should break up longer own instagram. Or what's app that that's make made them too powerful. We don't know how how that's all going to play out. Obviously the company will fight that very hard. So it's hard to know how that'll end up. But i think they have especially this coming year. Now that we're kind of past the election into a new administration. I think they'll probably see a lot more challenges. In that sense i think two thousand twenty one for facebook is going to be very challenging. In that sense. I don't know if it'll start registering to the actual business to the advertising revenues they generate and usage. And all that. But it's definitely going to create even more of those kind of headline challenges we've seen gotta info just taking a step back here. At the beginning of this conversation we talked about what a wild year this has been because of the pandemic for tack taken together. What all these results tell us about. How tech fared and what challenges lay ahead. Well i think. I think the strong results actually make their challenges. Maybe a little even more harsh because what we're seeing is that even in the midst of something that's been a pandemic so crippling is that these big companies do really really. Well i if they're going to make an argument that no we're not we're not so powerful as you say we are every quarter we get this reminder that no they're you know they're actually very very strong very powerful can grow their business when so many others can't i can make record profits when others can't so i think i think in a way. The strong financial results will really pleased investors but also makes the company's jobs harder to convince regulators and lawmakers that they're not a threat they are deemed to be right. Now i think that conversations going to really pick up in the coming year all. That's our tech columnist. Ian gallagher things much for joining my
Warner Bros.' Wonka prequel gets 2023 release date
"Wonka Prequel. Yeah, training yesterday. Tell me what is the prequel mean? I'm so comes before the movies that we know that this would be the story before Esso Warner Brothers is moving ahead with the Charlie and the Chocolate Factory prequel. It's just called Walker. At this point. The plot details have been kind of kept under wraps up about the upcoming adaptation will reportedly center around Willy Wonka's early days prior to operating his elaborate fact. The range in the really Wonka movie. They kind of mentioned when they're great. Paul Joe right there. Would you work with them? I think so. Yeah. So we don't know if the Opal Lupas will make an appearance. And maybe this will show the part where he meets the Lupus. There goes the Lupoli. I know. I don't know. But would it be an idea that you would say Yeah, I would probably check that. Did you say I'm sorry? I missed that. If he did, he said, who's playing Willy? They don't have that Cassidy. That's crucial for May. I would agree with that, so,
How to move forward with China
"To fourteen point list of grievances via the australian media. Second wine joined beef. Bali timber lobster call among our exports that the chinese communist party has imposed tariffs on. And then that tweet. This is the tweet of the posting of a digitally altered of an australian soldier about to slit the throat of an afghan child. The chinese embassy issuing a bellicose statement the rage in roar of some ustralian politicians and media was misreading and reaction. It said to deflect public attention from the horrible atrocities by sickness soldiers and to blame china for the worsening of bilateral ties. So what's going on. He and asha camera respond. Jeff rabi is a former australian ambassador to the people's republic of china and he's author of china's grand strategy and australia's feature in the new global order. That's just been published and it's available in all good bookstores jeff. Welcome back to the show so some great to be back now. I your thoughts about beijing's response to australia in recent weeks so we have that list of the foreign complaints the wind terrace and of course that tweet while a say i up disappointing to see the slights that have been made After the two quite constructive comments at the triumph prime minister a last week quite clearly. The prime minister was Diplomatically signaling That there was a strong wish to start a process of getting back to some sort of more normal relationship between the two countries the product make though it sounds dramatic when you run those three things together the way you have done that certainly not the same thing. And i'm not sure that they're all necessarily coordinated. I mean the fourteen points clearly seems to be freelancing by the embassy on matters that well known and in the public record in any case at a very odd way of putting something out if you leak it to a channel nine television crew that seems to be pretty casual behavior by the embassy then the tariff spo there has been a processing trained for months on the wind tariffs and i do understand that that was the normal process and the strain companies were busily making written submissions as part of that process. And then the tweet The present time it sounds like it's been contrived by the chinese foreign ministry as individual action. it was a tweet that was particularly widely on social media by a now nationalist artist and twitter and the foreign ministry spokesperson on his private twitter account. Pinder to name and so it's philippine. Middle level action doesn't really look to millions of any of these really coordinated broad cross section of the australian people just looking at the y. People who've responded this week is there is outrage and surely win china. does things like. This doesn't make it harder for people like you because you've been an eminent company on this issue for several years now. Hugh watt a bobcar. Pass gas on this program. Of course the former prime minister paul keating. Doesn't it make it hot. A all of you to make the case that al leaders should try to rebuild trust with such a regime yet. I can understand the public outrage especially the media is going into overdrive steer and just as you have said running all these things together as a coordinated action from the state It does make it harder to get sensible constructive discussion going a story about how we deal with these things. I like to find myself in such august company as you outlined. And you might add gareth evans. Many others that to the group as well but it certainly history doesn't help and it's difficult context in which to conduct foreign policy. What we're seeing is what is like to live in the situation with china relationships In a very poor state now. Other people in camera that i see welcome this their peopling camera who have the view that bad relations with china are inevitable. This is the new normal. We should get used to it and lupus it while the questioning myself. And the august company you've being linking me with. Is this the best interest of australia. And it also basic question. Your what has australia down to bring on china's in this way why you think china is picking on again. Picking on is quite pejorative. They're not doing this to other states. Our other key point. And i would phrase that differently tom i would say how is it that astray amongst like minded friends and allies other liberal democracies in the world in the region why's at the trial has become an outlaw and i think that really needs to be part of the public discussion. Isn't the reason. The australia is so over exposed to chinese pressure in beijing. Nosy so the chinese leaders going to inflict pain on australia whenever they can't australia. And not the other like minded way boy more. In other countries we ought to forty percent of our exports to china. No other country has that kind of exposure. I prefer countries in the region. China is by far the largest trading power. I mean that exposure would be the same for korea south korea which is liberal democracy in the region. it would be near that level. For nearly all the countries in the east asian region china is the dominant economic patna of all of the countries in the region and that is just a fact at its reflects. The extent to which china has grown as the dominant economic power in east asia. Alexander downer. The former. Foreign minister says that now's the time to reduce our exposure to china. But what everyone is saying. There's nothing new novel in that. And obviously when people start to realize that we are going to have for a long time a difficult and challenging relationship with china's manage. That's a fairly obvious. Point to make interesting from In addition to being former minister former director of the board of while clay. And very active Proponent in boosting. Australia china trade relations phrase time as soon as minister and i work very closely with him in that and i think we achieved a lot. So why wouldn't you wanna diversify every sensible business. Every sensible company diversifies the port made over and over again on this aspect is that it's going to be very hard. Because of the absolute scale and growth and prosperity of china. You are a foreign policy realist. All gripe house ruthless and that includes chana hardball at every turn and the stronger. China gets the more likely to throw its wide around now to the extent. These realist analysis is correct. How on earth do we solve. this problem. absolutely correct agree with all those points. Another point that needs to be made. And you don't make it much tom. And your pride yourself as being a realist and that is the relationship is asymmetrical that is effect. We need china. More than china needs us. This is not a comfortable place for us to be but it's a place we are. It's a place where we're stack and will remain and so We need to work out how to manage that relationship and we haven't done a particularly good job of a judging by the state rewritten today. So although you express yourself in a different way you essentially gray with the foreign policy realists professor join me shauna regular guest on this program and he argues that his china's power increases its definition of its national interests will grow and then beijing will seek a survey influence in areas on which its future security and prosperity dependent in response. The us will go to great lengths to stop china's rises. It essentially. your argument is well up a poet. I'm a great Admire of joint mish as well. I differ with him on a couple of points but his analysis and arguments have been hugely influential in helping me shape my thinking about these But i put on sphere of influence is. I think that's already happened. I think china is the dominant paranagua this at length in my book in eurasia from the east china sea to also china is the dominant parent. That's happened largely because sanctions against russia poor economic performance by russia Pushback from from europe against russia has meant that brushes had to cede to china's ascendancy in eurasia and so very part of the world. And i think we now live in a world of michigan talks about a world of two great powers with boundary orders and in the question then becomes is some equilibrium at stable between the two. And i believe there is.
The Gluten Connection to Osteoporosis and Autoimmune Diseases
"I'm Cassie Wenas. I've been a registered and licensed stay Titian for twenty two years and of those twenty two years I've been teaching nutrition classes and Co hosting this dishing up nutrition program for about the past fourteen to fifteen years. I am telling you this certainly not to make myself feel old. But to let you know that I have quite a bit of experience to share and I feel really fortunate to be able to be here this morning to help all of you listening better understand the connection between what you eat and how you feel. And today my co host Teresa and I will be discussing subject that I know a lot about and if we're being honest I know a lot about this topic more by destiny certainly not by choice we're going to be talking about the myriad of health problems that gluten grains cause for a lot of people as many of our listeners know I know a lot about this topic not only because of how gluten has negatively affected my health but what? Really drives, my passion on this topic stems from the fact that both of my kids have a condition called seal EAC and if you're not familiar with this autoimmune condition in a nutshell, it's when your body has a severe reaction to gluten and actually causes your body to begin attacking itself. It's kind of like the immune system goes haywire, and if you swallow even just a tiny speck of gluten, your immune system I begins attacking your own small intestine. So. Now you know a little bit about our topic for the day next, I'd like to ask a few questions just to get everybody connecting the dots as we delve further into what we call the dark side of gluten. So question number one, do you or a close family member have lupus. Do you or a close family member have rheumatoid arthritis or do you have a thyroid condition like? Disease or Hashimoto's thyroiditis. Do you have Raynaud's if you're not familiar with rain odds, I can explain from personal experience. Raynaud's is when the blood vessels in your hands and your feet. Constrict when you get cold and they constrict beyond what's Normal When the weather or the air is cold or it can happen because of stress as well, and then your fingers or your toes might turn white and you get sort of a burning pain not fun. Or is your Autoimmune Disease Scleroderma or type one diabetes. Do you or a loved one have chronic acid reflux or do you have osteoporosis if you can say, yes to any of these questions you're in for a super informative show today theresa and I WanNa help you make the connection between eating gluten grains namely the the Ri- The barley and most oats and your health problems. And as I just mentioned, my co host today is Theresa. I WanNa tell you a little bit more about her Theresa Wagner like me is a registered and licensed AIA Titian she to teaches many of our nutrition classes she of course, Co host this radio program. She's a mom of young kids and she counsels clients several days a week either by zoom or phone appointments because of Covid, nineteen were offering all of our nutritional counseling either by video or phone appointments. Yes. That's right and we are staying busy with those phone appointments and zoom appointments but as it relates to our topic today, cassie. Mentioned earlier that your kids CEAC. Disease. It made me think were you shocked at the many hidden sources of gluten when you started? Living a gluten free life all those years ago I really was shocked I had been a Dietitian for many years at that point by the time our family got diagnosed. So I knew gluten was inbred. I. Knew it was in anything made with wheat flour but I had no idea of the more hidden sources of gluten in our American food supply just to give you a couple. Of examples. Gluten is in some brands of Deli meat. It's in a lot of summer sausage and beef stick brands. It's in some ice creams for heaven's sakes and even in some medicines, not only that but when you have, CEAC, you have to be careful about personal care items to you need to be sure you're buying gluten free shampoo gluten free toothpaste, gluten-free Lotion, and gluten-free makeup. Yeah. It's so crazy to me that gluten is an ingredient in so many every day nonfood products. It reminds me of a client who had ongoing migraine headaches. We have limit. You know we had gone through elimination where we Eliminated. The dietary sources of what we thought causing the Migraines and we went through lifestyle habits that we thought could possibly be causing the migraines when we finally looked at her personal care products and switched to a shampoo without added gluten. Her migraines they disappeared.
Apple reveals lower cost watch and updated iPad
"Maybe with the event's title, we should have known it would-be. Short. Tuesday's time flies event flew past at just over one hour, four pieces of hardware, basically, as well as new services and the services bundle we're focusing on hardware today. Surprising, absolutely, no one apple on Tuesday announced apple. Watch series sex running through the hardware. The S six system and package packs a new dual core processor based on the eighth thirteen bionic an iphone eleven it runs twenty percent faster than series five apps launch twenty percent faster. It's the first. Apple. Watch to include the you one ship, an ultra wideband antennas. The series six always on retina display is up to two point five times brighter outdoors than Apple Watch series five. Both the same all day eighteen hour battery life is before and can hit full charge in one point five hours. To features focused on during the devices introduction where the always on all tinder and the blood oxygen sensor. Not sure why always on is important for an intimidator unless you're worried about rock climbing in your sleep Apple says the always on ultimate provides real time elevation all day long by using a new more power efficient, barometric, ultimate her along with GPS and nearby Wi fi networks. This feature allows for the detection of small. Changes above ground level up and down to the measurement of one foot. And can be shown as a new watch face complication or workout metric. More life and death or the blood oxygen sensor and is associated APP. Apple says, series six measures the oxygen saturation of the users blood. So they can better understand their overall fitness and wellness. Oxygen saturation or S P o two represents the percentage of oxygen being carried by red blood cells from the lungs to the rest of the body and indicates how well this oxygenated blood is being delivered throughout the body. And how it works is really cool according to Apple's presentation. The sensors are basically checking the color of the blood as it passes by. That color indicates how oxygenated the blood is, which is free again. Amazing. Speaking of colors for the to apple watches I've owned I've chosen brushed aluminum. It's easy to match with just about anything. But if you have a signature color or don't care about matching or. Planned to have plenty of apple watches on hand to put on your wrist Apple Watch now comes in the couple of colorful colors. For. The first time says apple a new blue color. Silver Space Grey and gold aluminum case options along with the product Red Apple. Watch. With exclusive matching, bright red bands stainless steel models are now available and graphite and an updated classic Yellow Gold Color Apple. Watch edition is available in natural and space black titanium. Series six also says Sayonara to ceramic while apple didn't mention it during the event. A piece from macrumors says, that is no more. As is the way the arrival of new apple watches also meant the arrival of new bands. This time though whole new bands, not just new colors. Sport Band makes way for so loop. No clasp. No buckle. Solo Lupus a continuous end stretchable ban design that says comes into materials, soft silicone and braided yarn. Nine sizes for those. Apples supposed to have a size guide on its site. Checking Apple side it looks like Sport Band is just making room not seeding the field. Both sport? Band and Solo loop available to order as of now, there's also said to be a first of its kind leather link that wraps around the rest held in place with flexible molded magnets. Nikewatch gets everything we've talked about already plus a new Nike face and new colors for the Nike Sport Band and Nike Sport Loop. Same goes for Apple Watch air MAS- as far as improvements the hardware it's stainless steel cases come and silver or space black paired with single or Dubna, tour styles and an assortment of vibrant new colors. Now about the only thing predictions got wrong for Apple Watch as E was its name. leakers had thought that that was shorthand that it'd be called something simple like apple. Watch. Apple Watch S E is the budget chronometers name. Well mid range chronometer Apple Watch series three is the true budget model still out there selling for one hundred, ninety, nine bucks. An apples press release apple CEO Jeff Williams was quoted as saying Apple Watch S E combines elements of the series six design with the most essential features of Apple Watch, all at a more affordable price. No Blood Oxygen Sensor and no, always on display. It does sport the always on all temperature though because apple is taking this sleep climbing thing seriously. Looking at the hardware sports the same size displays as the Apple Watch series five. The S., five system and package and dual core processor deliver performance that's up to two times faster than the Apple Watch series three. The S. E. Packs the fives haptic feedback for the digital crown, and that speaks and here's what the latest speaker and microphone in the watch line. Apple says, watch as e features the same accelerometer gyroscope. altimeter as Apple Watch series six and with the latest motion centers and microphone. It offers robust health and safety capabilities including fall detection emergency, SOS, International Emergency, calling, and the noise. APP. Now, if you decide, the six time is the charm that you're finally ready to buy Apple Watch. The one you buy probably won't have a charger in the box Lisa Jackson vp of environment policy and social initiatives at apple appeared during Tuesday's event extolling the environmental virtues of apples timekeeper. Sometimes. Jackson said it's not what we make but what we don't make that counts. That he's from seeing that says that when she said that apple won't be including USB adapters with this week's watches. As putting them free in the box consumes resources and adds to apple's carbon footprint. Interestingly, people who can afford to buy a charger without giving it a thought. Won't have to do so. A separate piece on chargers Napa Watch from apple insiders as apple, watch, addition, and Apple Watch. Will include a five watt power adopter. Bloomberg's Mark Gherman Kinda cried foul over that on twitter. Quoting his tweet looks like the Apple Watch titanium and Armez model still have the power adapter. So the more expensive versions keep it. makes it seem like it's less of an environmental thing and more cost driven? I can get thinking that as an immediate reaction. Here's the thing though you gotta figure apple sells at a minimum hundreds of entry level apple watches for every single edition or. Sold. Probably thousands. So even though it looks like catering to the wealthy and yeah, there may be a bit of that. Even though it looks like catering to the wealthy dropping chargers, millions of people probably don't need. Might make an environmental difference. No I saw way more than one piece saying not including chargers with Apple Watch is just the beginning. While, it has been rumored that the next round of iphones will also arrived without a charger. Apple doesn't seem to a pulled the chargers from the ipads that are also coming out this week. We'll get to those in a bit. Want to get an Apple Watch for your kid but not give them an iphone worried that mom or dad may have a slip and fall or ended up seriously directionally challenged apple has a plan to watch the whole family. Selling points as far as apple's concerned with family setup, you can stay connected with family members without an iphone from making and receiving phone and facetime audio calls to sending and receiving messages and emails, and even connecting with other Apple Watch wearers over walkie talkie. Parents have the ability to approve all contacts. So kids can safely use the communication features of Apple Watch, according to the company. The activity rings experience has been optimized for kids according to Apple. Emergency SOS is being pushes the benefit though. Apple Watch already does that. And finally school time and downtime or front and Center for children while optimizations focused on health for older relatives take precedence at the other end of the spectrum. Now the news that will make family setup less useful for many. It requires cellular models, of Apple, watch series four or later or Apple Watch S E running watch os seven paired with iphone six s or later running IOS fourteen. Apple also said that kids and older family members of the household using family set up, we'll have their own phone number through a separate cellular plan. So, while you don't need to get GRANDPA and the kids their own phones, each cellular watch will come with a tone cellular plan and. Associated Bill. Family setup goes live today and so by the way does watch Os Savon. that. was kind of surprise more on that a bit later. With such an emphasis on the health, it's not overly surprising that the new Apple Watch Slash Watch Os Combo brings a few new health studies. macrumors runs those down starting with an asthma study being run in conjunction with the Insurance Company Anthem and the University of California, Irvine. Second the peace says Apple has tied up with university health network and the University of Toronto to learn more about how Apple Watch metrics including blood oxygen can be used to manage heart failure. Finally macrumors says apple is partnering with investors at the Seattle, flew study at faculty at the University of Washington School of Medicine to explore how changes in blood oxygen and heart rate can be early signals the onset of influenza and Kobe nineteen. The watches by the way are ready to order now. Those opened on. Tuesday, they'll ship on Friday in the US Puerto Rico twenty seven other countries and regions. Apple Watch series starts at three, hundred, ninety, nine dollars adding cellular adds another hundred. Bucks. Same goes for the Apple Watch Nike and Apple Watch Air Mas- that the prices run higher on the AMAS models. The new bands are also available to now they too will ship on. Friday the eighteenth of September. Though only in the US and fourteen other countries and regions. Porters are also underway for Apple Watch as E. It's got a starting price to seventy nine dollars. Interestingly, adding cellular to that one only adds fifty bucks raising the price to three twenty nine. It also ships this Friday and the US Puerto Rico And twenty seven other countries and
Michigan To Pay Flint Residents $600 Million Over The City's Drinking Water
"Million settlement with residents of Flint over the city's drinking water crisis. The problems began in 2014 when improperly treated water corroded the city's pipes. And leeched lead into the tap water, making people sick. We wanted to hear what Flint residents thought. So we called up Jenna McDonald. She's a substitute teacher and mother of two young boys. When my co host Ari Shapiro, met Jenna four years ago in February, 2016 she had taught her boy's a really important lesson. We've continued to check in with her throughout the years, and she joins us again. Now. Welcome back. Thank you. So Governor Gretchen Whitmer called this a step toward making amends. How do you feel? What's your reaction to the settlement? Is like a little ray of sunshine it for me and for my family. My biggest fear is that everyone will forget about Flint. It would get swept under the rug, and no one will remember. So I'm very excited to know that our wonderful governor kept her promise about keeping this on her four part of her mind in their Flint residents matter. Much of the money will be devoted to Children who are six years or younger when first exposed to the contaminated water and your son's justice and Josiah fall into that category. Will you be seeking compensation? And is it enough? There is no amount that will be enough ever if each of us got the 600 million apiece that's still will not replace the damage that was done. I have very close friends who lost parents two Legionnaires. I'm still under the belief that my son's autism is a result of these lay a tainted water, so there's no amount of money. Deca, replace or even tried Tio comfort lifelong things like that. Are you going to see compensation? 100%? Yes. And you know, I've been thinking about this. You haven't been on the programme since the pandemic started. And I've really wondered how Cove in 19 has impacted you and your neighbors, especially with all this necessary, extra hand washing big, big amount of stress. You already tried to kind of limit how much you were playing or in the water are trying to wash your hands. But now you don't have a choice. I can live with whatever little damage that that late is possibly doing to my body and just meant through my skin. But I can't live through Cove it I have. Ah, you know, auto immune disease with my Lupus, So I think it would take me out. So I'll take my chances washing my hands with the Flint water versus getting called it. You know, during that last interview, you told
Sharon Stone on sister’s COVID-19 diagnosis: 'One of you Non-Mask wearers did this'
"Is revealed that her younger sister Kelly, who suffers from a Lupus is hospitalized with the Corona virus and blamed one ofyou. None mask wearers. Sharon Stone says her sister does not have an immune system. The only place she went to was the pharmacy. There's no testing in accounting unless you're symptomatic. And then it's a five day wait for results where a mask for yourself and others, please. Sharon there months. Hannah, I believe, and her sister and her sister's husband are both hospitalized. And Wow, it's her sister has Lupus. So she's got this underlying condition and she said she's fighting for every breath right now. So sour cheese.
Understanding Whats Really Underneath Your Childs Behavior with Dr. Pejman Katiraei
"Welcome to the brain podcast. I'm your host Droop wrote and each week my team and I bring on a new guest who we think can help you improve your brain health feel. Feel better and love more. This week's guest is Dr. Pettman Qatar Ryan Dr k as he's known to many of his patients is a board certified pediatrician who's also board certified and fellowship trained in integrative and holistic medicine. He completed his undergraduate at Ucla and then he obtained his osteopathic medical degree at Western. University of Health Sciences. He completed his pediatric residency at Loma Linda University, the famous Loma Linda. where, he stayed on as pediatric chief resident and then as teaching faculty for over four years while he founded the Loma Linda University holistic medicine clinic. Dr K also completed two fellowships integrative medicine one with the University of Arizona Dr Case. Second Fellowship wasn't Endo Bio Jeanie and thereby ginny as a European systems biology medical model, which emphasizes the use of. In the management of Neuro Endocrine, system Dr K. is one of a few physicians in the country with mastery of osteopathy functional medicine, functional endocrinology, herbal herbalism, medical herbalism, and more Dr K. is now in private practice here in lovely Santa Monica where he focuses on helping children with severe behavioral challenges incredible bio. Dr Kate Welcome to the broken being pot. Adding more LADES, you're young man, you're only forty-three. There's a lot more accolades you can add to your resume over the. Perfect job. A Mike my goal at the end of the day to help kids feel better. That's beautiful. Goal a beautiful purpose and I can't wait to dig into that in today's podcast and I wanna get into a little bit of origin story. How did you get clear and where did all the puzzle pieces aligned himself that that is your goal. You know. I think the universe was calling me. To do this. The first reason why I got into, it was for my own health up as a kid, I had pretty severe anxiety. SPENT, most of my adolescent teenage years in mix of anxiety and depression yo and. My nervous system was upside down and I couldn't really understand why I knew that I was different. I knew I experienced the world differently, but I really had no clue why you know like who would have thought that eating fast food everyday. All Day will be an issue for for your nervous system going bonkers is that what was going on? Were you eating fast food and kind of go? How is the standard American new way of life I mean college like that's what you do. Right Even I remember actually Loma Linda is a vegetarian institution. Why it's famous for being one of the hospital in the Blue Zone. The seventh day adventists. Yeah. But when I got accepted there, one of the thoughts that I had is like Oh my God. What am I gonNA do without my burgers. And that was the mindset I had going into training because I didn't know any better and what actually got me to start looking outside was during my training. I kept kept coming across these cases and I remember one very, very vividly. Twelve year. Old Guy. Severe Severe Colitis. Came in with toxic, Mega Colin were his colon had dilated to about ten centimeters, which is huge, and we did around the steroids. We did some medications for him. He got better when home. Two weeks later, I was still on service. Worse off than before and Beato, our team started the discussion and we brought in all the specialists and basically the end of the discussion was well, he's failing medications. We just need to cut out his colon literally was like he failed medications. So the next option is we just cut out this twelve year olds a lot inflammation. Something's going on. Let's just cut the thing out. because. That is the next standard of care, right. I had a lot of these kinds of scenarios where kids would show up like I remember another guy who plays soccer. He scraped his knee niece bowl up and then thirty six hours later, he was dead. You know and they were just like well, sometimes staff does unlike I've scraped my knee, I haven't died like, what was it about his system that caused him to fall apart and it was this recurring question of like these things don't add up two plus two equal in this scenario and the institution, and they're really smart people alone Linda, don't get me wrong. But the pediatric conventional training was like no two plus two equals farm like it doesn't look this way. So as it is in most hospitals and worst Western approach. Places. Because that's what people are trained in. But you were asking a different question. You're like, okay. This doesn't make sense what's really going on. Exactly. Yeah, and that is what ultimately led me to start taking courses. So I, I went to one holistic kind of course, and it was a dinky little course, but I was like, oh. My God I, you know I have found my people, the light bulbs went off and you started connecting dots. And then from there I went and did a bunch of training with Institute of Functional Medicine and the trading with the University of Arizona, and in the midst of that, I started realizing the pieces that were affecting me so like. I did the elimination diet and started feeling better and then I found myself to have MTA. And I think my initial homocysteine was sixteen when I first tested it, I'm like Jesus. So I started injecting myself with B twelve and you know I was my own best Guinea pig. And in the midst of getting interested, what also happened is Loma Linda's in didn't have anyone that was getting interested in this stuff. They're like, Hey, you wanNA, start a holistic medicine clinic and. Like. Two years of my training and there I was like all of the sudden getting handed these patients you know and I was the expert even though I basically didn't know that much. But through the process of learning and I was really really privileged to be put in a place where you know fifty year olds, I was a pediatrician fifth year olds with Severe Lupus. Land in my doorstep helped me I'm like. I don't know anything about Lupus. So let me learn so I. I spent all this time. Just researching in learning. You know any person that I could find with any material they had on the Web I was reading books listening to the videos. And I was just consuming all of this information in the midst of that. Also learning from my patients,
FDA ends emergency use authorization for hydroxychloroquine
"Federal regulators revoked emergency use authorization today of chloroquine and hydroxy clerical in to malaria drugs that president trump touted as potential treatments for covert nineteen the food and drug administration said today this drug may not be effective to treat covert nineteen the FDA said the drugs are unlikely to produce an antiviral effect and earlier observations otherwise the FDA said have not been consistently replicated Dr Simone Weil joins us from south shore health near Boston so what happened we are all trying to find a cure for Colgate nineteen act there was some profit with early studies that were done without the clerk went and everyone got on that bandwagon you really need to do something for these patients and there was a lot of promise however as we have progress and learn more we have found there's not a lot of any benefit to you I talked to Klara plan and that there's a lot of side effects we care about our work done about the yeah this is no small drug this is a powerful drug if they can treat malaria and it also used to treat lupus and rheumatoid arthritis so you know it has its particular you know but right but no specific study to say it's actually beneficial for covert nineteen so how big of a disappointment is this I think we all wore something that your Kobe nineteen routine so many debts and that healthcare professionals will help lead because we want to do something but I think that there is something that gets a cold we're going to go through it I think they did not really pan out the way we hope it works I know everyone including the president has tried it but I was trying to keep all of the data and that's what we're going we're going to buy it they find that the information that we have and date on the studies that have not been released take care there is not enough data to support the benefits are I thought the kora playing basketball coach in nineteen patients and a big error that ID back in particular the card yet I noticed though that the FDA said some of the clinical trials would continue is that a good practice given the potential side effects I really want to get more data in order to yeah and third what data not very effective for treating Kobe nineteen more thirty seconds but you know we don't want to continue giving it back up right now what what's the next best thing well you know we have a few things that we're working on and you know we're doing when does the day here as one of the big brown I mean I can do a lot with that is there are other biologic that we are using and of course the biggest thing is working on back seat it's rare that the public take such an interest in these kinds of treatments but this is the process is in a trial and error figuring out something that might work in and figuring out it doesn't work this is a long process although they are meaning once you have information that's going to be rather than about the date your browser then we go ahead and we continue that that is not very date I think a lot of people right so you want to stop okay Simone Weil's and ABC news contributor joining us from south shore health in Weymouth
Coronavirus: US withdraws emergency use of hydroxychloroquine
"The food and drug administration has ended its its emergency emergency use use authorization authorization for for hydroxy hydroxy Clark Clark with with the the drug drug president president trump trump touted touted in in the the fight fight against against corona corona virus virus ABC's ABC's mark mark rumble rumble are are joining joining us us on on the the komo komo news news line line what's going on with this mark yeah basically the FDA and other health agencies in the United States has said that since they first authorized an emergency use for primarily hydroxy chloroquine that's that's the main drug that we've heard about like quarter quarter Quinn as well said since they authorize that back in March in late March as more studies have come out as they've done more research basically they found that there isn't anything to stay statistically that there is a benefit to you using these drugs and that sensually the risks of these drugs which we know about these are decades old drugs that have been used for many other purposes they're not news so we know what the side effects are those side effects are really outweighing the benefit or any potential benefit and as time has gone on and they've done research they just haven't seen or been able to replicate some of these early reports that we heard back in March about the possible benefits of this these drugs and so while they issued this emergency authorization and time is gonna essentially say they can't justify continuing to allow this authorization and so they've rescinded it so they're saying ineffective and may also cause heart issues and now what is the White House saying about this after president trump talked about these drugs for quite awhile yeah president trump has been a a cheerleader of sorts for hydroxy Cork when and in fact claims to have used it himself for two weeks just a few weeks back when some staffers close to him and vice president Mike pence had tested positive he said very positive things to say about hydroxy chloroquine he says that he's spoken with medical professionals who have told him that it's a very good treatment and that they've seen very positive results it's had a great reputation and if it was somebody else other than me people say Gee isn't that smart however these agencies within his administration are essentially saying that that's not the case that there's nothing to support that that the risks that we know about outweigh the benefit of these drugs and basically the emergency doctor authorization had said that you need to take these drugs in the same dosing recommendations as you would for other things so the same dosage that you would take for malaria or lupus or other treatments that you use these drugs for and the FDA noted that the inability to go higher and higher dosage that could potentially bring on benefits would only lead to more risk so basically they were they hit a ceiling we can't take a higher dose of this and we're not seeing any benefit at levels that we know are safe therefore there's nothing essentially that we see as a benefit for the drug to be continued to be used and so especially the federal government will stop supplying this drug to state and local agencies for the treatment of cover nineteen only now lupus rheumatoid arthritis other think that these drugs are used for those will continue their unaffected but essentially that the FDA and and other health agency says this is this is not a valid treatment anymore ABC's mark rubble are thank you mark thank you
U.S. FDA revokes emergency use status of drug touted by Trump for COVID-19
"Federal regulators are stopping the emergency approval of a malaria drug once thought to be a possible corona virus therapy the food and drug administration is ending its emergency use authorization for Clore Quentin hydroxy clerk when president trump told reporters he took a drug the clerk went to prevent coronavirus infection but the FDA now says the anti malaria treatment is unlikely to be effective treating covert nineteen inotes Sirius side effects including cardiac conditions that outweigh the known and potential benefits of the drugs Cllr Quinn and hydroxy clerk when are prescribed for lupus and rheumatoid arthritis Jared Halpern fox
The Kidneys Connection to Our Emotions
"Today. We're going to go off on a different subject here about kidneys. You guys haven't heard us discuss kidneys very much in the past episodes but we thought with everyone being a little bit on the fearful angry side we would address kidneys because they very much have to do with those emotions. So the name of this show today is called the kidneys connection to our emotions. And we're going to tell you a little bit about what to look for when you might suspect it your kidneys what you can take to help. Get them better and we also have a question at the end that we're going to answer. So Dr Lewis. Could you tell us why you have chosen to discuss the kidney connection today on our podcast? Well Yeah I'd love to. I chose to do this because Janet wanted to. That's right that is true. You know I think the main thing is is because the throughout this Kobe stuff that I think is you know crock. Crap but You know we. We've been told things so long so loud. You know you can tell a lie long enough and loud enough people begin to believe it and so saying stay safe Co home. Stay home be safe in. Its implying that US people like me. That think it's a crock that get out or sinful and where. The enemy were being brainwashed. Folks you've got to think past that and I'm absolutely amazed at the people that choose. It's a choice. They choose to cower down in fear and and we've noticed that people are more agitated more irritated and that's me because I can't believe that idiocy that's going on like trying to get into home depot and his lap. Geez there's one hundred and fifty feet between everybody but you're worried about how many people walking in the store and one of the reasons that we as a society besides the mental spiritual they're throwing at us is because we're eating incorrectly. We're drinking to excess with when it talks when you talk about alcohol. Excessive to me is very little but Done tight much and we get irritated because we're putting our her kidneys under stress. One of the worst things you can do is have high blood pressure that you don't take care of either medically or naturally or both because at high blood pressure can really calls all kinds of problems with the kidney so please please please take care your kidneys. It it's incredible is super important but kidneys are their damaged from all sorts of things like certain drugs are really really tough on the kidneys and you have to watch that and you know. Have your doctor that puts you on the medications to monitor that but heavy metals our society full of heavy metals. It's full of solvents. It's of a chemotherapy. Does that Different Benham's snake insect spider and I went through a lot of that after God only knows how many Brown recluse spider about gotten and it will wreak havoc on your kid. He's poisonous mushrooms. I don't know anything about that because I don't experiment with those mushrooms that grow on cow patties like some people. I know Do it because it's a psychedelic psychogenic psychotic or something Pesticides and we know we've got pesticides all over the. It's really really really common in our food. Which is a sad thing and herbicides and people say but I'm not around our besides York Janet. I was coming to work two days ago. And there's the Texas highway department spraying herbicides. Oh Good God but you know us a goat to eat but we have done that to ourselves with the poisons in our society and renal failure and not even failure but when you put your kidneys in stress it can add to things like congestive heart failure diabetes or diabetes slash Metabolic Syndrome. Can put pressure on your kidneys. It can go both ways and lock said before the chronic hypertension a bad thing liver disease liberal ever you got. The liber is like a woman. The Lib rain happy. Ain't nobody happy. And then you have diseases. The autoimmune diseases like Lupus and sickle cell. Things like that There are people that have genetic tendencies the have issues with Kidneys like poly cystic. Disease and kidneys. Are They Tennessee to have mineral accumulations that she usually calcium? And we see that into your analysis. It'll say crystals calcium oxalate. Now you know. We can't make any claims about supplements but if you're having calcium oxalate stones that usually means you have a lack of magnesium or potassium to offset because we get minerals that out of balance. And that's the problem with our society mentally and physically because we get out of balance we forget to laugh. We forget to you know have a good time and I just love people that come in here and I'll go hug their neck and watch them freak out or I'll shake their hand and it's like you know we've been doing this for tens of thousands of years and it's not an issue in. Don't you enjoy the HUG and s? You're actually I do I. I like the way you social distance dot because I don't social distance. That's one of the things we're missing. Now is the social interaction. That is way way more important than any other thing now again. I I said disappear. Podcast AGO that they're scripture somewhere to Bible. I forget probably proverbs but is a wiseman foresees danger and takes precautions K. And I think that's a smart thing to do but the Bible also says in Titus very plainly. God didn't give you a spirit of fear so quick fear crap You talk about stones oxalate downs in nineteen seventy four when you say stoned rattling talking about oxalate stones. The ones that are GONNA be urine. Just what would those manifest in normal? Layman's terms that someone might understand that. They may have a kidney problem. Kidney Stones you know very sharp pain in the back and you know This is because one sweetheart of a sweetheart patients or no the different parts of magnesium and we're getting people that say well. I have this symptom and they want me to diagnose Office set a symptoms everytime time Janet. I give a list I say. Be careful though because these same symptoms can go with a different organ. Be careful how you diagnose off of just symptoms but one of the things That you can bet your bottom dollar as you're deficient in magnesium so I had this sweetheart patients they can you explain the different types of magnesium. I'm saying that because there's plenty of research says if you take magnesium it buffers The bad side effects of calcium or calcium oxalate stones that that's research that and it says be six. Pp and potassium so let's talk about. Magnesium purchased a little while because magnesium can take the anxiety irritability that we are feeling and. I think is obvious in my voice. It's like oh good. God quit despair crap but if you take magnesium there's actually research says magnesium if it's the right form can work even better. I'll stress anxiety. Depression era ability and anger than many many many drugs and again we can't make claims that but the research says it so let's talk just briefly about the different types of magnesium if you poop once a day or less unietd magnesium citrate now. We have that for people. They say about once as normal permissiveness common. But it's not normal. He got three trains in three trains. Out Is Janet says about three meals and three meals out so citrate because it was bound citric acid. And that's a pretty large molecule. And that's why you don't get enough in a multi vitamin or multi-mineral. Because it's a large molecule. Takes up too much. Real Estate It's a mild laxative. And so it's it's a great choice. Then you've got magnesium oxide folks it. They're putting oxide in your multi-donor multi-mineral throw it away. Because that's the cheap crap that yes it works as a laxative. But you don't really absorb it where you can absorb more the cows of magnesium citrate then you got the magnesium glassy night and it's a pretty gentle form that's what I'd generally suggest for people that have hypertension It slower going through the system. It absorbs a little bit less water. So you end up. Absorbing more of it It glasses night. Actually it's Connected to an Amino. Acid glossing blessing is incredibly incredibly incredibly important amino acid to help form neurotransmitters and calms your nerves.
Despite risks, Trump says he's taking hydroxychloroquine
"Trump has been taking the anti malaria drug hydroxy Clark went for at least a week and says the reason why is because I think it's kind of a lot of good stories and if it's not good I'll tell you right I'm not going to get hurt by it it's been around for forty years for malaria for lupus for other things I take it what do doctors think Boston children's hospital epidemiologist Dr John Brownstein says it has not been approved by the FDA because there's no proof it works trials scientific research has also shown that this drug is not effective against Kobe nineteen and in fact their potential negative consequences like heart rhythm issues and even death so horses struggles been around for a long time it's used to treat malaria and Lucas but there's no reason to be prescribed energy here right now given the evidence that we have today
Coronavirus patients treated with malaria drug hydroxychloroquine touted by Trump are MORE likely to die, new trial finds
"We still need more research on which drugs are the most effective in treating cove in nineteen a recent study looking at records from the V. eight shows that there is no overall benefit from using hydroxy Cllr Quinn it was actually two more deaths in patients that were treated with it alone then in combination with the antibiotic azithromycin for more on what how Joxer Cllr Quinn might not be the most effective treatment for corona virus will speak to Chris Rowland business of health care reporter at The Washington Post so this is a study that basically bolsters the deep uncertainty there is around use of hydroxy Cork win and in combination with as it's from my son as well antibiotic in terms of both efficacy and safety there's only been a some very small studies and this is actually one of the first that had a fairly large number of patients and what they did was they the A. and academic researchers at the university of Virginia and the university of South Carolina took a look at patient records looking back so it's called a retrospective study and they look at the records of patients at the VA who had been treated for corona virus and they selected out a bunch that had been treated with hydrochloric when a bunch that have been treated with the combination of Hydroxycut o'quinn enters it from my sin and then the third arm was patients who received neither of those drugs and what they found was that and the hydroxy clerk when alone arm there was like around a twenty seven or twenty eight percent death rate of coronavirus patients compared to the ones that had none of the drug and their death rate was around eleven percent so the death rate was higher for the hydroxy Cork when treated group they also found that when it came to ventilation there was really no meaningful difference between the arms so this antimalarial did basically nothing in terms of keeping people off and layers is someone disappointing I mean this drugs have been used widely and again no one knows whether they're safe and effective in here we have evidence that they're not and it's tough we're speeding through the process on a lot of different levels here because the pandemic hit so hard and so quick so that's why the president had been touting it and say Hey people are having some success with it go for it but we didn't have the studies done to really tell us what was going on that's why Dr Anthony Fauci from the task force said I can't endorse that thing just yet one interesting part of this study they look at all males which is we've heard of that cove in nineteen hits males particularly hard I don't know if there was anything to that is just all the people that were in this were male this is not peer reviewed it's not a randomized placebo controlled clinical trials so it's a little different from a full full on study it's kind of a quick and dirty way to try to scoop up some data and see what the effects are is you just go into the computer systems at your disposal on an anonymous basis a bunch of patient records the reason it was small man by the way since VA where I guess the VA population in general is mostly male there were a small number of women in their first pass and they just left all the women out because it was so small and so it indeed it's not compared to a placebo which is like a dummy drug which is really the gold standard of trying to figure out whether a drug works because say you can compare again in this one you don't know any any of these arms exactly how many of those patients would have gotten better weather without the drugs so it's very difficult it makes the comparison pretty murky but again it shows that the reason these drugs have been used is because there is no treatment approved for corona virus these drugs are on the market for malaria and also for lupus and rheumatoid arthritis and they were readily available so people just started trying them based on some belief that their entire inflammatory effects would have benefit yeah and it's turning out that they may not want to talk a little bit more about hydroxy clerk as you mentioned earlier I mean all this points to just the uncertainty of this this study cautioned that we shouldn't be using this so widespread until we know more about it but there are some known side effects or using hydroxy clerk when some cardiac death there was a French study a Brazilian study that both had problems with patients developing heart problems and I guess there's something called QT prolongation which kind of affects the timing of the hearts of these are some of the things that have been popping up with the use of this the side effects of Hydroxycut work when are well known and alarmingly as it from my sandwiches the antibiotic that's been using combination also has the same side effect of extending the period between your heart recharging and if your heart is re charging more than half a second it takes more than half a second to recharge time before beats you're in a position where you could have a dangerous arisen mia which could lead to sudden cardiac death it's a very serious obviously dangerous side effect that pops up in about one percent of patients who take this drug and manageable when you're dealing with a small number of patients who take it but when potentially hundreds of thousands of people are starting to take it or a million then you're gonna have you know as many as ten thousand people suffering serious cardiac events and possibly dying and that's why you know the president came under a fair amount of criticism for pushing these drugs so aggressively when there is this clear side effect and efficacy is really unknown against corona
FDA warns against malaria drug's COVID-19 use outside hospitals
"This morning the food and drug administration is warning doctors not to prescribe a malaria drug that was widely touted by president trump and by fox news for treating the new coronavirus outside of hospitals are research settings the FDA alert warns of reports of serious side effects and deaths among patients taking hydroxy caloric wind and related drug chloroquine the decades old drugs which are prescribed for lupus can cause a number of side
Trump Urges People To Take Hydroxychloroquine: 'What do you have to lose? ... Take it.'
"And I say it. What do you say to get? What do you have to lose on Saturday? President trump again touted the use of hydroxy chloroquine an anti-malaria drug as a potential treatment for covert nineteen the USC announced has stockpiled. Twenty nine million doses. Though the basis for using the drug to treat the disease is entirely anecdotal. Some doctors are already using it in hospitals around the country. Some report that it might be useful in the early stages of covert nineteen. But we really don't know. And what do we have to lose? There are side effects. Experts warn and it is potentially fatal for patients with heart problems or who are on certain antidepressants. And then there's the side effect of a shortage for people who are actually prescribed drugs clerk in four illnesses like lupus and rheumatoid arthritis yet. We have to be careful Laura that we don't assume something works based on an anecdotal report. That's not controlled and I refers specifically to hydroxy chloroquine. Dr Anthony FAUCI Director of the National Institute of Allergy and Infectious Diseases has been urging caution in White House briefings
"lupus" Discussed on News Talk 1130 WISN
"Answer but with a one percent population reveal we haven't found anybody who has covered nineteen who has a diagnosis of lupus and address the clerk went and none of the hide chronic patients on I got to work with had contracted lupus I mean a protracted so with that nineteen so none of the four people I will present a look as people had the flu and that you know the detection coronavirus so that was our thinking we were how what is the what's going on here is is there is that evidence so we approached delivered verbally Benton task she's the head of Medicare Medicaid right speaks at the deceit CMS and she has agreed to protect help and participate they have forty million people in that program has a lot of data and then we also approaching all the blues programs Blue Cross programs across the country and in the majority agreed and we're going to cobble together tens of millions of medical records and charts reviews and we have a very effective way of using big data deep analytics to figure out is this just an eight eight eight observation as because of the blood not really big deal or are we understanding that's pretty significant the I. S. DEA and Paris he said the same thing manifestations have lupus and I got to work when I asked doctor walls in your practice personally I'm a patient yet is eight hundred how many have called the nineteen said non S. cedar Sinai how many rheumatologists forty big practice they did a thousand admissions one patient who wasn't taking the medication and regular fashion at Copa ninety not another one in the whole group you think to be high risk so I'm I'm not sure yet I but I'd cancel I'd buy this and recently been publicly with the shoulder marks normally I wouldn't it I'm trying to attract people so is it a PPO listening to that Hannity show now if you know someone or if you personally have lupus taking aggressive Cork win and you have covered nineteen please let us know it's a it's a doctor about common the whole page we want to call you will understand what happened I'm looking for literally one person in the country where this is true I'm sure we'll find people but I would identify which if that's the case what happened with you the fact we find nobody what you're seeing right now is that there's a good possibility this is prophylactic applications am I wrong we don't I don't I don't it's a good possibility nothing is possibly getting me from thinking that from what I've just seen you want to be dissuaded so if your if you take hydroxy Cork win for lupus rheumatoid arthritis go to dot what's with Dr oz dot com or we'll look at handy dot com make it easy but we'll we'll put it up and if people should contact you all right here's what I only ask for those that are attacking the president acting me first putting people like you on and putting other doctors on a put many doctors on that of saying the exact same thing is being widely used all around the world this is irresponsible one Ohio lawmaker wants to sue president trump for saying Hey what do you got to lose the American medical association your life okay give us the evidence of that because I don't see it do you see that the American medical association right I don't I'm not quite sure what was going on with that like I saw it and I I'm just like obamacare let's put it that way but go ahead well I'm I'm look I'm asking people who do this for a living and they're scoffing at the physician response to this and they think it's actually influenced by people writing stories about complications that are religious those article but I just physics those two yesterday about how do you combine it with with that but the diabetes medications is toxic so that I guess that's part is we have a huge number of diabetics with his medication they have no issues and then I'll get the paper to read study they gave literally ten times more than you would ever give a human right right yeah so so let me ask you this and my being a responsible telling people Hey after all I've read if you in consultation with the doctor want to take it out that's kind of that's what I would do I'm not a doctor that's what I tell people it might be an irresponsible I think most doctors would agree with you we have evidence that the most doctors I know he lives I mean that's the point well anyway not because we're going to have the latest you're going to I got I had a late night on Hannity tonight go ahead thank you I don't want to have an anti intellectual movement against science I think it seems that we're back but what if the doctor deal engines your up and coming doctor Hannity the doctor a doctor does two things you ask questions only because you'll never learn it all you ask questions and you search for solutions so I don't know exactly what we're trying to do it is a cheap inexpensive product it is the standard in other countries I just don't understand it it is come and the risks based on old you've read and everybody that that prescribes this is low that's what you just got done saying probably prescribe prescribed according to the people do it it's extraordinarily so hello all right Dr Russell C. on Hannity tonight the numbers are much.
"lupus" Discussed on Mayo Clinic Talks
"Like that and it's just treated as cutaneous lupus however a large percentage of individuals with cutaneous lupus unfortunately can present to systemic lupus over time so clearly dermatologists rheumatologists need to kind of keep an eye on them now. Drug induced lupus separate entity and individuals can actually develop systemic lupus like features secondary to medications. We know them as Procon amid mini-cycles hydrology and among many others now there or is an entity call drug induced cutaneous Lupus as well that can be brought on by medications. We use a lot of them. Such hydrochlorothiazide calcium channel blockers. Ace Inhibitors Editor Stanton In those types of things So there are as you mentioned a variety of of of different reasons for systemic lupus continuous. lupus bend kind of drug induced Lupus as well in those who have a drug induced case. Does the disease tend to remit when the medication is stopped. I typically yes and that's one of the kind of finding that we see lupus true systemic lupus should would not just remit if you take away medication. Well let's talk about treatment demint what's out there for For treating the disease sure so in general Especially for primary care physicians. It's important for counseling of these patients. Avoid this unhealthy diet exercise. Achieving the goal weight staying up today with a mediation smoking cessation if they smoke. Those are kind of a generalized kind of thing. So Oh from rheumatological perspective Mild disease may be controlled on hydrochloric when But unfortunately more severe disease especially kidney were lung or heart or CNS disease requires more aggressive immunotherapy and can include chemotherapy agents biologic cytotoxic agents and even in some transplant. Medications should we as primary care providers be referring our patients with Lupus to a rheumatologist. Absolutely absolutely the quicker you can get them into better and Studies have shown that the earlier intervention is started these individuals. Joel's actually do better. And how about follow-up are are we capable of managing these patients than Alone eventually at if the the rheumatologist really should be involved as much as possible. Because there's certain blood tests are recommended Specially checking kidney function. Blood counts those types of the things on an every three month basis and so Those blood tests might be able to be done In the community. Primary care those types of things but if anything pops the that was suspicious Right back to the rheumatologist you go and that some of the medications you using have their own problems we need to be monitoring as well without a doubt. Many of our medications require regular blood testing especially the chemotherapy. Drugs biologics and cytotoxic age. So I I've been always very grateful to have the assistance of rheumatology in in my patients. It's very difficult Disease to manage how about About pregnancy can patients with Lupus ever successful awesome pregnancy yes Patients with Lupus can have a successful pregnancy but it requires careful planning and coordination between medical disciplines so a patients with Lupus as we know are higher risk for pregnancy complications It is recommended that conception be delayed until the disease is under control for at least six months and if at all possible the disease kept under control throughout the pregnancy. Now a couple of little things that are important. One thing is that individuals individuals who have positive S. S. B. Those are immune markers Require really close fetal monitoring because there's an increased risk for complete heart block and those those individuals with a history of anti fossil antibody syndrome or clots in the background of Lupus or history previous myth miscarriages with those positive of antibodies are really at risk for additional pregnancy loss. And so the use of anti coagulation can be protective to help out with that pregnancy. The fact that the disease is so much more common in females than males makes. You wonder if there's some hormonal component to this does pregnancy itself because of one of the flares so so we have seen that Unlike rheumatoid arthritis where the standard was thinking. Oh well if you have rheumatoid arthritis you get pregnant. Disease kind of melts away during the pregnancy. Unfortunately unfortunately that's not so true with Lupus and could actually kind of be a cause of flares. In the increase disease activity very close monitoring is necessary. What's new either now or what you see in the horizon for the the diagnosis or management Lupus has always been a challenge You the couple things new in terms of the diagnosis of Lupus the Two Thousand Nineteen the American College rheumatology in the European League against Rheumatism Basically put out a new classification criteria to help individuals. Think about how Lupus should be diagnosed and so that that was something new For for our field in the treatment. Realm Bouma mob Really has been the first biologic that was gained approval. FDA approval approval in two thousand eleven. Since then there's been multiple medications that come up to the plate but unfortunately they've all struck out the most recent Biologic called NFL. It's an interferon. One inhibitor showed released a mixed clinical results. And they're scheduled to submit for FDA approval this year but we'll have to hold on and wait and see if they'll approve it well. It appears that you'll continue to see. My patients are not using any medications. I can't pronounce sure what have without a doubt the tough stuff around this Let's finish up by asking you to give several summary points regarding either the diagnosis or management of Lupus. Yes sure I think it's important to remember that lupus is really a chronic. It's multi system autoimmune disorder in which the clinical findings blood tests and pathology are really relied on to make a diagnosis. This is not simple. Also a diagnostic challenge because all the diverse clinical Presentations that can happen. And the clinical course can be very very varied from patient to patient and so I always kind of when I'm talking to my fellow or Other individuals about Lupus. I always say you know careful. Initial evaluation is crucial to approaching patients. I mean which lupus is a consideration. So you know you you get the right workup. Kind of looking to see if you can document To help diagnose Lupus and then of course clinical suspicion and serology points towards lupus purpose expedient consultation with rheumatologists can be very helpful in confirming the diagnosed as well as guiding treatment. All right thank you run. We've been discussing seeing the diagnosis and management of Lupus with Dr Ronald Putin. Dyke a rheumatologist at the Mayo Clinic in Jacksonville Florida. Ron Thank you so much for sharing your expertise with with us today. Thank you for having me you can now listen to over one hundred different. Medical topics developed for primary care. Even our old ones back when we were really good. Ed Mayo Clinic Talks podcast. Find them at C. E. Dot Mayo Dot. Edu or your favourite podcasting APP. If you've enjoyed Mayo Clinic talks podcasts. The please subscribe stay healthy and see next week..
"lupus" Discussed on Mayo Clinic Talks
"However as you alluded to you know one of the most challenging things about lupus is it's it's very presentation and so on one? Extreme Lupus can present as Pulmonary Hamid hemorrhages renal failure or CNS disease while on the other extreme patients. May they developed FIDO Kenia presentation. Is it known why some get this disease are the risk factors for the development of lupus that we know about. That's a great question so our understanding regarding why individual develop lupus is really continuing to grow but the exact ideology remains unclear. Unfortunately finally there does appear to be a genetic component so for example studies have noted that there's a high concordance rate in Manos. I gotTA twin The risk of developing lupus. If your sibling has it is twenty nine times higher than in the general population and seventeen times higher. If you have a first degree relative that has lupus now. We have some studies with the Genome Wide Association. Studies have identified over fifty. JEAN-LUC CY with polymorphisms that that predisposes individuals to Lupus the challenging part of it is that even the presence of these only account for about eighteen percent of the susceptibility to lupus suggesting that there's other contributing causes and so some studies are looking at the geography race appears to have some impact. We know that lupus appears to be more common. Urban rather in rural areas in the US the prevalence of lupus is higher in individuals in Asian African Americans African Caribbeans and Hispanic Americans compared to Caucasian Asian. Interestingly enough though lupus occurs infrequent LII in Africa so probably some genetic predisposition -sition to the disease combined with some environmental exposure. I think we have a lot yet to learn absolutely well. lupus is. It's like nine to ten times more common in women than men any thoughts as to why that is sure so we do suspect that hormones play a role so we suspect this from observational age related studies so the ratio of females to males with Lupus was three to one in children when the role of sex hormones are likely minimal but ranging from seven to one to fifteen to one in childbearing years and then changes again down to about about eight to one in postmenopausal women when compared to age mash and matched males so also the president of the x chromosome appears to be important it carries at least three predisposing gene variants. And there's also evidence for gene dose effect so if for example the prevalence in excess X. Y. hi Individuals Climb Filter Syndrome is increased fourteen. Fold and men with Lupus when compared to the general population of men whereas ex oh which we know is Turner or syndrome is underrepresented in women with Lupus. Our audience is primarily primary care providers. So when should we suspect Lupus. What symptoms would patients present with that we should say this could be lupus short so good? Clinical local history physical examination and some blood tests are very important so we do know that there are some symptoms that we I kind of alluded. To in the beginning of the discussion with with joint pain photosensitive rashes ulcerations. In the mouth riddick chest pain. Those are the types of kind of more generalized symptoms. That we kind kind of think There may be something autoimmune. There may be something lupus like going on when I was in medical school. They taught us about the Classic Butterfly. Facial rash sure is that is common as we suspected is or is that relatively up Thomas Though there have been some studies and the how how common it is at presentation ranges between about twenty eight to thirty eight percent of the time but a butterfly rash anytime during the disease is higher. It it goes up to about forty eight to fifty four percent of the time so it is at least gonNA be in a quarter to a third of individuals at presentation now with osteoarthritis rheumatoid arthritis. These two conditions have typical findings on radiographs. X Rays. does lupus have any classic distinct re graphic features. So actually it's distinguishing feature is that it's non erosive Compared to other other types of inflammatory authorities such as rheumatoid arthritis and story attic arthritis which do cause of roast of disease so the x rays may actually be normal. Okay now I also remember when I was first in practice we basically had an a. and that's what we used. Things have gotten a little more complicated. What tests are out there now if we suspect Lupus so there are some generalized blood test? I recommend I basic lab testing like a CBC CBC looking for Steidl Pena's serum creatine looking for renal dysfunction inflammatory markers such as the said rate and the CRP and a urinalysis to look for a Toria protein area and fellow cast. But you did review. Br refer to an A. N. A. Preferably we like to get it by forescent but there are other tests such such as a double stranded. DNA An e n a panel which includes various different markers for autoimmune disease including Lupus we also like to check for anti is possible lipid antibodies Lupus anticoagulant and something called an anti Beta two glycoprotein antibody as well as compliments C. Three C.. Four those types of things which can get give a practitioner. Better Kinda feel as to what types of autoimmune disease may be going on and hopefully point to the one year suspecting. Yeah it's much more complicated now and I think this is a plot by rheumatologist for Jack Security for. I can't keep track of all of the door parameters anymore well As I mentioned sometimes patients come in. We think it might be Lupus. Maybe the test. Don't confirm it But what we ended up telling them mm-hmm is sometimes. It's GonNa take a while for this disease to declare itself. So how common is that. We have to wait before we can establish a diagnosis without a doubt. Making being the diagnosis of Lupus can be a challenge. Secondary really to the Heterogeneity of the clinical symptoms and the lack of Pathmanathan features are lab tests the challenges inches. That symptoms can be intermittent Those with more mild disease manifesting as prominently just photo sensitivity and arthritis may go years without had a diagnosis because the symptoms are relatively mild. And so the diagnosis is also based upon access to medical care including primary care as well as rheumatology I know that the variety of courses that Lupus can take. Is there a typical clinical. Course for lupus boy. I wish there it was so the clinical courses varied Just like the types of symptoms that people may experience during the course of the lifetime some individuals may have gradually progressive asked of disease other more intermittent relapsing remitting disease while some may actually present with severe disease and then have a relatively mild Clinical course afterwards afterwards and unfortunately they can have any mixture of the above so. It's a true challenge. That will occasionally see a patient with rheumatoid arthritis. They have it for years and then it kind of burns out and then they're pretty much symptom. Free does does lupus ever do that. I've seen that in some individuals yes They have horrible disease. Or you know early on in life of very very very aggressive and then as time goes by kind of burns out as well and there's a perhaps a hypothesis that as as we age our immune system is not as robust and perhaps that's contributing to a calming down of the other patients. I've had have had flares periodically throughout their lifetime. is any thoughts as to what causes these flares at emotional stress medications. Anything any ideas. Sure general things that can cause Or lead to flares include Spun exposure especially in lupus patients. stressors as you alluded to psychological or physical goal surgeries Injuries infection smoking is also associated with higher disease activity and there has been some studies. Also show that that individuals who are diagnosed with Lupus before the age of twenty five or those with renal vascular or neurologic disease also have increased risk of recurrent players. Now with lupus. There are complications which which occur. What organs are typically involved with some of these complications? From lupus of virtually all organs of the body can be involved with Lupus and that's one of the challenges. Individuals can have issues with skin joint. I- kidney liver lung heart Men and the GI system so no Oregon is really spared in terms of potentially involvement. That could make it also very challenging to to manage these patients now. There are a variety of types of Lupus in the morning are all related. Are they separate distinct entities Systemic stomach lupus cutaneous lupus drug induced. Lupus and I think there's a few more sure so you know when we talk about. Systemic Lupus It can also cause Catania's disease without a doubt but when we talk specifically about cutaneous Lupus it can present really when that's the patient's only manifestation of lupus justice skin and no underlying triggers such as medications or those things.
"lupus" Discussed on Bloomberg Radio New York
"Dot org brought to you by the lupus foundation of America and the centers for disease control and prevention this is Bloomberg businessweek Carol master and Jason Kelly from Bloomberg radio this is what business week does so well Jason take something that many of us probably take for granted and I'm talking about vanilla yeah I certainly take it for granted is sitting there in the spice cabinet although we have noticed over the last couple years of the anybody he's paying attention to expensive price has bite at times in a really meaningful way well there's a story behind that Monty real he has some of those interesting assignments because some of the most interesting places and this story took him to Madagascar are likely for us he's back home in Chicago that's where he joins us so Monty tickets to Madagascar are and to this market yes this is a regional market this is the place where vanilla actually enters the international marketplace and it's really remote it's really kind of hard to get to it's basically a hot a wooden high in a really small villages in northeastern Madagascar which is the vanilla growing region and deceive unit idea of how tough it is to get there see flight Madagascar's capital you take a small plane to a small airport in the northeast then you have to drive over really really bad roads to try to get to this particular market area and for example when we did that our driver couldn't go any further because the road we were on was actually swallowed by river so we had to Wade across the river likely it wasn't very deep and then walk for a couple hours beyond that to finally reach this little hut really in a in a village where dozens of farmers would bring their annual harvest of vanilla and that's where it would be bartered bought over by international flavor companies and exporters and then go out into the wider world yes it is a great line your story you talk about where you went as this great observation lab that I want to take your words exposes but the genius and insanity of globalized commerce I mean that's exactly what you start work yes met it's almost hard to imagine some of the things that happen in the vanilla trade in terms of for example just how the crop is paid for its all cash it's a cash economy so the buyers who go to these markets half to get cash you know along the same route that we took to get there and the biggest denomination bill in Madagascar is worth about five dollars and these buyers are buying tons of vanilla beans and these even though it means coming when they're cured can cost as much as six hundred dollars per kilo so they need lots of cash so there's actually they bring bales unveils of cash to these markets on the back of motorcycles and and just being carried and that's just one example of kind of the the strange market that vanilla is because of its isolation there in Madagascar are and also because of the the price swings and so much yeah I have to say reading this story in Caroline I've talked a lot about it this week just between the two of us at our desks this notion of how is this market so limited to this one really obscure place because this is not one of these things that candidly you read about in the back of pursuits where you know only people who are billionaires can get this mean this is something we both have right in our homes how has it been so limited to this one geography well it it comes from an orchid vanilla grows from the flower of an orchid and it's actually native to Mexico but many years ago that it was basically transferred Africa and it was found that it grew very well in Madagascar are and just you know vanilla is not one of those products that can be grown like soy beans or something like that easily manage commodity it really is a stubborn crop as people grow it describe it it likes to grow among other plants and it's incredibly labor intensive so every step of the growing and cultivation process is done by hand even the pollination of the flowers to get the beans to grow is done by hand so it basically it comes down to one of the main reasons why Madagascar dominates the trade so much is labor costs the minimum wage in Madagascar for agricultural workers is about eighteen cents an hour so you know in talking with people who work for vanilla companies they talk about trying to grow you start plantations and other tropical areas like places like Indonesia there are countries in Africa that have started to develop a vanilla industry but they say that you know that works well when vanilla prices are at highs but whenever the prices tank V. it becomes financially unstable to to invest.
"lupus" Discussed on Z104
"She joins me in the studio this morning along with Tonya, Butler committee member. Also Johnson this year. He's the chair of the public relations and marketing he won't be talking it for moral support right? To you both. Good morning, Jesse. Let's start with you. What is lupus and what causes it? Lupus is autoimmune disease, which basically, your body doesn't recognize the good pathogens from the bat. So it attacks everything. So basically, you're skiing, your loans, your heart kidneys. Anything is fair game for it to attack. I'm not sure understood that you know how your body produce antibodies so off. Okay. Okay. Our body. It can't tell the ones to get rid of and wants to keep safe, so it just attacks any and everything. So how manifests itself, but you're subject to Kohl's viruses, L is different for everybody can speak them me. It kind of manifest it in a rash on my arm. That they just thought was contact dermatitis until the dermatologist did a skin biopsy. Evans have lupus. But they thought it was disquiet lupus. See there's different types of lupus, discord lupus, primarily just affects the skin and you have to be careful being out in the sun, things of that nature systemic lupus, which is the one, I had that means any and everything is being attacked you. Is affect my blood? My brain. My skin, my joints. And sometimes muscle weakness. Who gets the disease contracts lupus. Oh, gosh. Is it, it doesn't discriminate, anybody king? Have lupus. Young girls. Have lupus is primarily affects African American women. But again, it doesn't discriminate men get it Caucasians Asians. Anybody can have lupus torn new job of a house was it? Lupus can be treated with preventative medicines steroid, steroidal medicines creams ointments like she said it can affect any part of the body. I'm it actually affects my skin. Mostly fatigue joints. Lupus is more prevalent in African American women. It starts like she said, nobody did it doesn't discriminate between anybody. But usually is young women between childbearing ages. Maybe seventeen and up. It can be very debilitating. But it does it doesn't affect me, as it does chassis. I don't have as severe symptoms as she does it can affect the nervous system. It can cause strokes. It's a nasty disease, so many different symptoms house. Like diagnosed, I mean, you've got a skin rash, you know, thought, oh, it's just to. Dermatologist. Both in muscle aches. You could be real. You could have Rheumatology rheumatologist rheumatoid arthritis..
"lupus" Discussed on Rants and Randomness with Luvvie Ajayi
"And so I'm looking on her Wikipedia page to research, and I see to Sheena is an advocate for lupus. And I thought it was like a small sign from God to just say, you know, I'm with you through this and to to continue pushing forward because what are the chances that? I'm diagnosed with lupus, literally the person I'm going to interview, you know, is this advocate. So I didn't tell her in that moment. You know, very quick you sit down for the camera. You ask your question. But just being there with her was like, this is I'm gonna get through this. And so from there, you know, I it was just a journey. Sometimes I was up. Sometimes I would take him medication. You know, being healthy getting rest of the time. I wasn't and I was really pushing the limit because I was in denial. I'm like, I'm young I feel fine. No, nothing's gonna happen. And whenever I would start pushing those limits. I wasn't taking my meds. I wasn't pleased. I wasn't eating. Well, I would have a flare or I would end up, you know, with pneumonia. Name that really did it made life hard. So I say all that to say when you move from the nihil when you move from fear, and then you'd walk in accepted. You know, you walk in your courage in your confidence in your face. You'll see your life change. And once I accepted that this is a part of my life, but I can manage it things changed for me. I got healthier, you know, I was able to just not carry that that guilt anymore. And then I was like, hey, I feel comfortable talking about this naturally people like Nick cannon, Selena Gomez, Toni Braxton seeing them be open about their illness. But also bear their journey Namie feel like if they can do it. I can do it too. And so yeah, shared my story at the end of twenty eighteen and a half or feed nothing, but love and support. And frankly when you carry it can make you sick. I think it makes you sicker. When you're when you're carrying, you know secrets and you're not getting the poor or community is that you have to tell everybody was going on. But you have to have some kind of face free. And once I started to talk about it, it became less of the thing. And now, it's just it's a part of my life. But it doesn't define everything that I am. How how has lupus diagnosis changed? How you operate day to day? If it has yet, it it really has. I mean, the first step is I we of people in the lupus community or like, chronic illness is something called spoon feary. Basically every day you wake up a certain amount of boom. Right. And so doing an activity will take away from those do one thing it's a trade off, you may be left with you know, only one or two spoons for the day. But for me, I prioritize completely differently. You know, I don't I don't waste energy. You know? I know a lot more I used to want to be there for everything and everybody and just feel really guilty. If I couldn't come through do a story or or go to an event now, I just have choose like, if I do this thing that means I can't that..
"lupus" Discussed on WNYC 93.9 FM
"Lupus help one Diego had translated lupus invective on this religious subject to many times. He clenched his teeth his lips tightly closed not uttering a word. Guadalupe had been corrupted by the Catholics Lupe began. She was our virgin, but the Catholics stole her. They made her the virgin Mary's dark skinned servant. They might as well have called her Mary flav, maybe marries cleaning woman. Blasphemy sacrilege unbeliever clear. Shouted dump boss didn't need one Diego to translate lupus diatribe here heard lupus sound off about that. Well, a Loupe business before it was no secret that Lupe had a love hate thing. Going on with a lady of Guadalupe. Also, new Lupe dislike mother Mary. The Virgin Mary was an imposter in the crazy child's opinion, the virgin of Guadalupe had been the real deal. But those crafty Jesuits had stolen her for their Catholic agenda, in lupus opinion that dark skin virgin had been compromised, hence corrupted the child believes that Our Lady of Guadalupe had once been miraculous, but wasn't anymore. This time. Lupus left foot delivered a near lethal kick to the weather Lupu Dr. But the suction Cup base held fast to the dashboard while the dos shimmied and shook herself in a frankly less than virginal way. In order to kick. The dashboard doll Lupu had done little more than arch her lap upward toward the windshield. But even this much movement 'cause one Diego to scream. You see? Now, you've hurt your brother better cried. But Lupe bent over Diego. She kissed his forehead, her smokes smelling hair falling to either side of the injured boy's face. Remember this loophole whisper to hundi ago, we are the miracle you and me not them Justice worthy miraculous. Once she said. Where the miraculous ones who undergo whisper..
"lupus" Discussed on WIBC 93.1FM
"There. And welcome to the voice of health with our house. Dr Robert pray third of the prey thir- practice. Where lives are changed every day through the natural approach to healthcare. We're talking today about lupus and educator you ten of this the heartbreak of lupus certain why why call it the heartbreak of lupus, well, mainly hits women from fifteen to forty four. So. You know, when you talk about kind of putting your life at hole in one of the most important parts of your, you know, development. You know, when you see on ladies who have lupus and just the suffering that they're going through and all the different types of things that occur. It is heartbreaking. No, you've you have a. Just kind of like a desire to hold them uncomfortable and tell them it's going to be. Okay. Right. Right. Well, let's talk about lupus, what is Luke Beth. Well, lupus is an autoimmune disease basically where the by starts to attack itself. So for some reason, the the body has determined that some part of your system normal tissue is a foreign invader and for lupus. The main area that we think that occurs is the bloods, white blood cells and red blood cells is what the body touches the antibodies to has decided that that's a foreign invader which causes a huge amount of of affects throughout the system. That that's one of the reasons that we mainly find the the the the age from fifteen to forty four usually during the time that women are producing ministration. And there are times where through abnormal hormones have normal functioning part of the metro blood can get out into the Donald cavity and haunted. Does than the body. Start is designed to get rid of that. So it produces antibodies that 'cause white blood cells to come in and eat up the abnormal tissue there. But then when the body starts to reckon to say that all red blood cells. Oh, wait. Let cells are foreign invaders and starts to put antibodies on it. That's when you start to get this the lupus. So there's an abnormality. In other words, the the soldiers have turned on the citizens, and in the case of lupus the soldiers are actually fighting each other. So pretty devastating type of a of a of a program, and, you know, something it's very devastating disease. So something that needs to be figured out with and isn't lupus one or the other heartbreaks of lupus is it's very difficult to diagnose. Oh, it's very difficult to diagnose the interesting thing about the the lupus is it's great imitator. So it's oftentimes mis diagnosed people think it's something else. Going on matter of fact, it usually takes about six years from the onset of symptoms to the that's the average that they find. And then usually they go through about four doctors before it's diagnosed so six years from from getting it diagnosed giving the proper diagnosis as important to find the proper diagnosis to be able to to to get lupus under. Control because it does need to be treated in a special way. So are there different types of lupus? There are the most common one is the stomach lupus, and that's more the organ involved lupus where you start to have different parts of the body being attacked. It's about seventy percent of all types of lupus. And the main thing that mainland that we're talking about the other one is a cutaneous lupus. Where all the symptoms are on the skin, and that doesn't cause any internal problems with came custom scarring. So that's difficult. One. Also, there is a drug induced lupus. Where you're taking some form of a drug oftentimes sofa base antibiotic. And I can kick off a lupus. But it usually stops. You know, you actually stop the lupus once you stop the drug, and then also a Neo Natal. Lupus. Whereas the mother's antibodies are actually attacking the baby. So but once usually after birth and that usually goes away. So we're gonna talk about mainly me said as seventy percent of the cases, right? It's called what systemic lupus systemic lupus. Okay. So how common is lupus? Lupus. Actually has about according to the lupus foundation has about one and a half million Americans have lupus right now. And it is also something that hits mainly more women in child bearing age. Okay. So mostly women mostly women ninety percents of all patients who are diagnosed with systemic lupus are females. And again, usually between the ages of fifteen and forty four. Is when they're when they're diagnosed with and who gets lupus, the interesting thing is that there's also a. Genetic component that also goes along with that. So if you have family members who've had lupus than you're much more likely to get it. It also seems to be a stronger and more devastating in women of color. So Caucasians have the the probably the lowest incidence of that. But black Latino Asian women have a higher incidence of lupus than the than the Caucasian fam- Caucasians. Okay. Interesting. So what are the symptoms of lupus lupus, the the big thing that occurs with Lucas is quite a bit of pain? It's something that people really suffer with trying to work with that is trying to get the pain under control is one of the. Main things that needs to be done. There's an extreme amount of Teague. So you don't have a whole lot of get up and go you can also have some hair loss starts to occur cognitive issues because of the the spreading of it throughout the body, especially causing lowered oxygenation because of the attacks on the small arteries in the body, physical impairment, cardiovascular disease. Again, it hits the red blood cells and can cause damage in the arteries. We also have strokes. It has a higher incidence of strokes. You can have some disfiguring rashes, which we talked about and then very painful joints. So it's something that makes it very difficult to carry on your life. Do your work continue your studies. So it really cuts down on on the quality of life. Is lupus. You talked about a little bit that lupus has a genetic component. Right. More about that. Well, there are several different genetic markers that show up that it has a much higher incidence in certain type of people. So there are genetic markers that go along with that that kick that up one of the things not only is it. If family members have had Lucas, also if other family members have had other autoimmune diseases and oftentimes if you have lupus than you also have some other autoimmune diseases to one of the more common ones is how she motives for the thyroid oftentimes go along with that. So, you know, really keeping your again, it's an abnormality of the of the immune system, which is the soldiers of the body. And when the soldiers start to attack. The citizens. That's when you get the immune diseases and systemic lupus is one that really spreads throughout the entire body in effect. So many different types of areas. Trying to keep that under control and keep that from causing damage is one of the main things that needs to be done as as you're trying to work with the patient along those lines. Yeah, I think we talked about the the heartbreak of lupus difficult to diagnose but on attends isn't misunderstood it. Is there have been a lot of of women who've come in with lupus, the first thing that they're put on is anti-depressants. You know, there is oftentimes of feeling that it could be just in their head there. Causing different types of. Mental stresses things like that. And here take this. And and don't bother me. So, you know, and then also just giving them. Pain release which doesn't really help one of the things about taking pain medications. Especially opioid medications is overheads are very good for the Q types of of pains for the first two weeks, but opioids any especially with lupus increase the pain level. So obvious are giving to patients with lupus. Anytime that you have a chronic disease like that. Opiates are the absolute wrong thing to take it will increase your pain level, not decrease your pain level. But then you also get the start to get the addiction. Addiction on top of the lupus things can be a real problem. So misdiagnosis. Prescriptions that are wrong nonstop, the you can't really go along those routes, and if you have the diagnosis of lupus, it really makes it much easier to follow the the medication schedule as you should be. Okay..
"lupus" Discussed on KQED Radio
"So you can choose a serve different levels of privacy with a lot of these services and so for example some people will say i want you to look at my dna i want you to tell me about my ancestry i want you to tell me about for twentythree me they'll give you a few bits of information about your medical conditions and that's it but they will try to get you to opt in to sharing your data for their own basic research so at twenty three me for example there's a whole team of researchers were studying all sorts of things all sorts of diseases sleep patterns and so on and then they will also go into partnerships with drug development companies who will take their data looking at say fifty thousand people with lupus and fifty thousand people don't have lupus and try to look for the genetic differences those good point the way towards possible drugs so to sum up there's some amazing breakthroughs being made in genetic research there's so many questions that remain i know i'm stealing the obvious here but it sounds like there's a lot that still really inconclusive yes you know if you just look at the genome and look at all the things that we inherited from our ancestors you know there's just a lot of it that scientists really can't tell you much about it all it's it's still a pretty poorly explored frontier and heredity is so important to us it it really is how we explain who we are and how we got that way by looking to our ancestors and saying what did we inherit from them and so we really wanted to tell us all sorts of things and now that we can start to look at her on dna we want those answers right now and the simple fact is a lot of those answers either aren't there yet or we'll never find them in our dna so when you decided to have your genome sequenced and that was really part of the research for this book as he knew you'd be writing this book brace yourself for the possibility of bad news that you would find out that you had a gene that showed you.
"lupus" Discussed on Bulletproof Radio
"Atherosclerosis is immune driven it's an auto immune mechanism so this topic of auto immunity really becomes a primary concern for all of us but we never looked at it that way so once we understand that this is prevalent in almost all of us that it's an auto immune mechanism meaning your immune system attacking your own tissue whether it's your blood vessels or components in your blood vessels that vat fatty membranes of the blood vessels or your brain or your joints or whatever it is when your immune system is attacking your own tissue that goes on for years it's called the spectrum of auto immunity it goes on for years before you ever have a symptom i'll give you an example because this study was a paradigm shift for me back in two thousand three dr melissa our buckle an md phd she went to the va and she looked for for people with lupus the auto immune disease lupus and she found one hundred thirty two people in this one va center that were being treated for diagnosis of lupus now if they're being treated in a va center there veterans if they're veterans they were in the armed forces if they were in the armed forces they had their blood drawn many times over the years when they were healthy in the navy and the airforce marines and what most people don't know is that the government has been saving and freezing most of that blood since nineteen seventy eight they've got tens of millions of samples of our service people's blood so dr than a second does this mean that vampires in the military you know that's a really good question dave i really don't know why they're doing this but they're doing it you know it's awesome they're doing is keep going i love this study by the way talking about.
"lupus" Discussed on WVNJ 1160 AM
"And look but um they have been thoroughly purified thoroughly tested do not have to worry about mercury or in fact twenty eight uh different contaminants actually a total of thirty two contaminants that might be in fish oil but are not in the carlsson fish oils now there was a uh very interesting finding out of san diego this week showing that higher intake of omega3 fatty acids was associated with better sleep quality and a decrease in depressive symptoms there's that connection again this time in lupus patients um and so we know that we pacific chronic longterm inflammatory autoimmune disease and an unknown trigger in this case causes the body's immune system to attack its own healthy tissue the most common type of lupus is systemic lupus the reese matosas if complex multiple symptom disease that causes inflammation pain and damage to various parts of the body it occurs nine to 10 times more often and women than in men and it's two to three times more common among women of color now omega fatty acids having in uh and an effect on inflammation in the body with the omega3s generally acting as anti inflammatory and omega six is generally acting as pro inflammatory and our western diet has um on average somewhere between ten and twenty five times more omega3 fix proinflammatory than omega three anti inflammatory so this is suspected to contribute to the chronic diseases that we struggle with so i'm researchers at the university of michigan in ann arbor looked at their patience and they they looked at omega3s and reduced disease activity in lupus patients and they found an improvement in disease um and they also found reduced disease activity so um this is an important finding what this means is that um increased omega six is associated with more activity of lupus increased omega3 was attributing to less disease activity in lupus and aside benefit that they found were significant decreases in depressive symptoms and better sleep quality so this is um an important finding and something to pay attention to and this is not the first sleep finding with omega3s and and not the only one there was a very interesting observation in made by the parents of children who were taking omega3s four b 'have your and learning issues in the united kingdom and.
"lupus" Discussed on Happier in Hollywood
"With a butterfly rash across the face and rashes along all my limbs and my hair was falling out and chunks granted lega it at the time i was a member of a pop rb group with motown records when i was in a from the age of twelve to fifteen and we were touring the country so that's a different amount of stress vr a child that age and exhaustion and exhaustion and on top of that i was still enrolled at a private school have sown ruled buckley so the pressure of all of that plus the exhaustion from actually performing every day um at the time it was a round the late eighties early '90s lupus wasn't a condition that people really knew about uh i think recently awareness of lupus is heightened so it took a very long time to diagnose the first thought it was an allergic reaction they thought it was dress biopsy after biopsy the on my skin they couldn't they couldn't figure it out until finally i was sent to a rheumatologist and i had all the markers and i was finally given a diagnosis and then i started in a life on from his own and i've been on from his own ever since on varying doses and even right now i'm i'm on you know handful of medications just to manage your how is your approach to managing lupus changed over time only recently have i come to terms with my limitations oh even with living with it for so long even after four lifethreatening flares years and years of therapy and and also just exploring any kind of alternative treatments or anything to supplement my western approach i finally come to terms with embracing what it means to live with lupus now granted i.
"lupus" Discussed on Happier in Hollywood
"Is a get done right what story problem we heads encountered what needs to be fixed before we start shooting tomorrow morning so i would say now that is shifted to only talking about our little girl yeah so i think that's good we've sort of found our relationship again in becoming parents and there's more of a separation were not as precious about the work anymore carr's ainu truthfully shield was our our first baby via yeah you know you could look at it that way but now we have our our real babe who takes up a lot of time and attention and and and of course it's not all 'harmonious at all in a while of course we do get into our spats when we are writing as i'm sure you've experienced as partners not but um because of the personal level because of the marriage factor yes it could get a little heated and then it bleeds into other areas we've gotten a very good about understanding okay this is a work issue and this is a life issue um let's highfive in know that we love each other of the under this heading yeah and you have been accomplishing all these amazing things well living with lupus since you were fifteen for people who are familiar with lupus can you tell us what exactly it is i'm lupus is a chronic autoimmune disease that affects all the tissues in the body cousin of inflammation throughout the body and it can go anywhere so basically i have an immune system the produces antibodies that attacks may tissue um my organs and it can run the gamut from minor inflammation to inflammation of of major organs a kidneys lungs brain it's basically all i know so when someone pointed out to me like how do you do it and i was like all right i don't know any other way and how did lupus kind of first rear its ugly head in your life it first manifested as the typical lupus rash which.
"lupus" Discussed on WVNJ 1160 AM
"And look but um they have been thoroughly purified thoroughly tested do not have to worry about mercury or in fact twenty eight uh different contaminants actually a total of thirty two contaminants that might be in fish oil but are not in the carlsson fish oils now there was a um very interesting finding out of san diego this week showing that higher intake of omega3 fatty acids was associated with better sleep quality and a decrease in depressive symptoms there's that connection again this time in lupus patients um and so we know that we've this is a chronic longterm inflammatory autoimmune disease and an unknown trigger in this case causes the body's immune system to attack its own healthy tissues the most common type of lupus is systemic lupus the reese matosas it's a complex multiple symptom disease that causes inflammation pain and damage to various parts of the body it occurs nine to ten times more often and women than men and it's two to three times more common among women of color now omega fatty acids having in an an an effect on inflammation in the body with the omega3s generally acting as anti inflammatory and omega six is generally acting as pro inflammatory and our western diet has um on average somewhere between ten and twenty five times more omega3 six pro inflammatory than omega three anti inflammatory so this is suspected to contribute to the chronic diseases that we struggle with so i'm researchers at the university of michigan in ann arbor looked at their patience and they they looked at omega3s and reduced disease activity in lupus patients and they found an improvement in disease um and they also found reduced disease activity so um and this is an important finding what this means is that um increased omega six is associated with more activity of lupus increased omega3 was attributing to less disease activity in lupus and aside benefit that they found were significant decreases in depressive symptoms and better sleep quality so this is um an important finding and something to pay attention to and this is not the first sleep finding with omega3s and and not the only one there was a very interesting observation in made by the parents of children who were taking a mega 3s four behavior and learning issues in the united kingdom and randomly the parents just said is is there any connection with sleep because my child is sweeping more.
"lupus" Discussed on 77WABC Radio
"Groans so the the pain is brutal are meeting ringo nausea i clearly understand that eager but i would rather like to look at the underlying causes and see if there are other things that are causing inflammation now remember just because someone has ankylosing spondylitis 'samina they can't have a another a flat matori issue whether it's rheumatoid or whether is allergy to something that they're eating we've seen patients with little new diseases we check your vitamins minerals hormones a test for the allergy mechanism allergens out of their died if their food elgin's there and then people have a decrease in that part of the inflammatory cascade so for many people as well for rulli tried for lupus for a mess other things that are described as autumn unionissued research on corona mark murders now the myintu stemcell nervy here yet done cells are cell therapy very well be at this one i'm actually trying to say so holland people have rheumatoid lupus ms and some of the more a horrible autoimmune even sklar germer this research on that her val disorders this research on stem cells how could we may be able to create a decrease in the inflammatory cascade with stem cell therapy if you look at my website when you look at the bottom uh 1800s thirty six articles their articles there that talk about stem cells helping with all of those diseases i mention rheumatoid lupus scleroderma cetera these are all prebid autoimmune disorder so worker i appreciated plumber aren't you come under thank you very much your.
"lupus" Discussed on KKAT
"Heal her body mind and spirit so that she can actually go forth and help others because toy is in the process of developing a website and her own mission for people that have struggled with lupus as well in its beauty beyond lupus is that correct troy we tell us a little bit about that yes actually this is this is the real exciting part for me because this this wormlike seen the whole point of all this in a it's a way to help people have selflove help people loved themselves more in well is in particularly those dealing with autoimmune diseases lupus is it's weird because it it affects everyone differently i've been fortunate in some sense is that it hasn't permanently disfigured me but it it does do that to some people in so it's one of those things that one of those issues that you have to deal with where he just don't phil beautiful amee wiggham swollen he can't glad in a cernan isj is yet he don't feel really good about yourself in in the physical sense neil let alone inside what you're dealing with so i just want people to two people to go deeper and develop that selflove in and when you do feel better about yourself it does reflect on the outside so one of the projects that i'm doing with yudi beyond leave this is a and learning how to sell a look gaining any skill so that i can treat them like headscarves stylish little gloves like these that will protect you out on the elements keep you up covered if you're having some disfigurations but i am still acute in the process so gis it's a work in progress very much i think probably bought the domain name yesterday is is that new but is is exciting in in is shedding new light wore me as far as what this experience is supposed to be about stood to pay for it to pass on the love because lupus has taught me how to love truly in her own others to feel what what i'm feeling right now on the inside well it's so beautiful toy i'm i'm just so inspired because i think when you have experienced it yourself when you've gone through it and you have just that deep experiential understanding of what it is to feel.
"lupus" Discussed on KKAT
"To getting well she's been struggling with his her entire life since she was a little child and were were wanting to get her well and healthy and back to herself so she can start this new mission with some new oh the beauty duty beyond lupus in helping other people and uh so toy i have another question for you you're starting this beauty beyond lupus w when when you're when you go down in you get this assistance how how long as a program alone what are what they're his program initially it took about a year to go through the completion remem only has always doing it on a payment plan of course money as you know is always a factor in the in the timing of things so i i did the slow pace but um i think they have an accelerated programme where he can do it in one to two months so and that's what you're hoping for right now that's what i'm hoping for ahead of already changed my dieting clean some things up as forest my lifestyle as concern so of already started the process even before i go i'm i'm i'm committed to to it so one way or the other l l get it done yeah you're committed to being healthy again to make in that powerful impact in the world helping other people had of struggling with lupus through your website and it's going to take you work maybe a couple months to go down there and to get that treatment to to heal your body he quins although systems so that you can view that powerhouse seat exactly at can be like you but yet go in oregon by oregon down to the cellular level inc basically just bring the body back to balance in that's kind of a the the cornerstone of dealing with an autoimmune diseases stain and balance so that once you get.