23 Burst results for "Lateral Sclerosis"
"lateral sclerosis" Discussed on KOMO
"Until the official handoff Saltz will retain his place on the Starbucks board after the transition Cathy O'Shea northwest news radio The price of gasoline not the only consumer product that skyrocketing in Seattle right now according to a Seattle times analysis of the cost of living index the prices of margarine up 47% potato up more than 38% in a bottle of typical white table wine 31% more than a cost a year ago the nonprofit that did this research concluded that Seattle has the 9th highest cost of living in the country Well as the economy continues to recover from the pandemic there is another bright spot for Washington and a factor explains a new survey from wallet hub compared the 50 states and the District of Columbia across 28 key indicators of economic performance and strength Factors include things from GDP growth to startup activity to the share of jobs in high-tech industries turns out Washington has the best state economy Utah California Massachusetts and New Hampshire round out the top 5 West Virginia is at the bottom of the list Northwest news radio will last month month of May was ALS awareness month and still those who are fighting for approval of new treatments for the life threatening disease are hoping people will not forget what's at stake We have more from carlene Johnson People's ALS lose the ability to move eat speak and eventually to breathe 2016 we were faking and I noticed that I was tripping and falling a lot And having trouble going uphill Christine Gilmore was not diagnosed until early 2019 despite those earlier symptoms she is now in a wheelchair still somewhat independent but as a tireless advocate for others she is pushing the FDA to approve new medications proven in trials to be effective 35% of the patients on this trial 35% of them actually improved We got function back The FDA said 35% wasn't enough I think giving one treatment See if it works for that ALS or amyotrophic lateral sclerosis commonly known as Lou Gehrig's disease affects as many as 30,000 people in the U.S. with 5000 new cases diagnosed each year Carleen Johnson northwest news radio Northwest news time coming up on 6 ten Let's get caught up on sports Now Mariners and Astros play long ball in the lone star state Bill Schwartz with his Beacon plumbing sports updates Rick the baseball has been flying far and often admitted made park in the opener of a three game series Houston already has three solo home runs off Seattle lefty starter Robbie ray The Mariners had two men aboard for their second inning round tripper This is gone On its way out to right field see you later Cal rawley He goes deep again It's a three run bomb and downtown Houston in the Mariners Have taken the lead right back Aaron goldsmith en route sports game tied now four four in the second inning Lindsey megs announced his retirement after 13 years coaching the University of Washington baseball.
"lateral sclerosis" Discussed on The Carlat Psychiatry Podcast
"In one thousand nine hundred eighty. The society for neuroscience began lobbying congress to increase funding for neuroscience research and on july eighteenth nineteen ninety. Their efforts paid off president. George h w bush signed a formal proclamation declaring the nineteen nineties the decade of the brain. At the time i just started working at the national institutes of mental health and the excitement was palpable. You could not go to a meeting or a lecture. Without hearing a reference to the new initiative and the promise at held and by the end of the decade most people judged it a success. Here's a few accomplishments from that decade of the brain the discovery of neuro plasticity before the nineteen nineties. Students were taught in psychology. Wanna one that. The brain was a static organ that became kind of set in its ways by age. Twenty five. now they're given a more empowering message through neuro plasticity the brain changes throughout life. Use it a lose. It is the mantra or is dr arnn. Put it in his bestselling book. Change your brain change your life. Thanks to these ideas. Older adults who taking up usable instruments. Aerobics dexterity games in hopes of reshaping the brain and staving off dementia. The we also learned that some periods of development with critical than others such as early childhood which led many states to launch preschool education programs. Next the discovery of genetic mutations responsible for huntington's disease emmy trophy lateral sclerosis enrich syndrome. Genetic advances like these have now ended clinical practice and no. I'm not talking about could. Genetic testing testing four neuro developmental disorders with a genetic basis is now a routine part of the world cup for autism and intellectual disabilities. If you're not already doing that. Look for it in our upcoming june issue. This year will show you how also from the decade of the brain the discovery of the neural origins of alcohol use disorders and then of course a rush of new anti convulsants and second generation antidepressants and anti psychotics. That decade is long past and if we had to anoint. The research of the current day. I'd call it the decade of the body and brain the assem continues to uphold a firm line in the sand between the brain and the body with the exclusionary clause that the symptoms of most disorders cannot be due to the direct physiologic effects of another medical condition. That line which looks so clean and sensible in the textbook is getting increasingly blurred these days as we learn about the multitude of ways that physical health impacts mental health. It looks like they blurred the line a bit already in the transition from dsm four today esim five in the all day to exclude symptoms that were due to a general medical condition while indecent five. The wording is another medical condition that word another suggests psychiatric disorders are medical conditions as well in reality. I'm hard pressed to think of a patient who psychiatric disorder was not impacted in part by their physical health. It's often said that when a patient has treatment resistant depression that we ought to go back to square one and look at whether any medical conditions like hypothyroidism. Anemia or vitamin deficiencies are causing the depression. And i hope our listeners will diligently run a lab panel like that check out our june twenty eighteen issue on treatment resistant depression for a list of what to include. But i don't think our listeners are very excited to hear this advice. Because they've learned from experience that those tests are fairly low yield in fact. Endocrinologist are currently debating whether we should routinely test for thyroid problems in depressed patients because false positive rates are high and we end up treating a lot of cases of subclinical hypothyroidism. That in the view of our endocrinology colleagues do not need to be treated. I myself am on the fence about the issue. I understand the endocrinology position. But i'm also aware that thyroid supplementation is a valid treatment for treatment resistant depression so you may not find that elusive general medical condition. That explains all your patient symptoms but you can make a big difference by pausing to consider how they physical health is impacting the brain particularly in depression. That boils down to at least three categories all of which overlap and influence each other in some way one that includes the hypothalamus pituitary axes through which so-called stress hormones like cortisol flow as well as reproductive hormones to inflammation on this one we have numbers inflammation contributes to thirty percent of cases of depression. And when it comes to treatment resistant depression that number jumps to fifty percent. The causes of inflammation many. Here's a short-list stress. From childhood trauma to recent stressful life events infection with active or recently like within the past six to twelve months. Chronic medical illness especially arthritis. Autoimmune diseases chronic pain as diabetes cancer and heart disease obesity particularly obama. I of thirty recent chemotherapy or radiation and recent bodily injury all surgery one of those recent infection has become particularly relevant in the kobe. Era this month. A new study found that fifty two percent of covid nineteen patients developed.
"lateral sclerosis" Discussed on The Last American Vagabond
"Adrenal insufficiency hypothyroidism alka alzheimer's disease a might oh tropic lateral sclerosis okay do. Ls parkinson's disease prions disease prion disease where this is a continually recurring thing. We see coming up in regard to covid nineteen and the vaccines lupus might. Oh crohn's disease. Non non hodgkin's lymphoma neural tube defects infertility. Hypertension like coma. Osteoporosis fatty liver disease and kidney failure. You realize that explains easy. It can easily explain the wink all of those things. that's crazy. Correlation data together with the direct bio bio biological evidence make a compelling case glide say action as a glycemic analog to amount for much of glysophate life as toxicology four five years ago right. We're talking about how this is a basically altering your dna towards chronic illness. That's being used for obvious reasons and here. We are spraying around the world. I find that to be very telling with where we are right now but just as we wrap this up on global safe recognize that this is two thousand sixteen as well. The pit the piss test heard around the world. One hundred fifty european parliament members take a urine test glide say guess what spoiler alert every single one of them tested positive for in their urine every one of them. Guess what happened after that. They kept using it in the united states. Here's another one monsanto's glyphosate found in all wines tested napa valley even the organic ones. Which by the way now means. They're no longer organic but they don't. That's not going to happen though. Because they pretend that life was say doesn't count they make it all organic anyway but technically speaking. It's not organic. that's the case. The whole world was longer organic since drenched global state in. The sense of organic foods term terminology. But we're talking about this in its every wear mo-. Santa weedkiller founded fourteen popular german beers. And these were like craft beer companies. That did this for generations and and these are beer that they're very very careful to make sure that they're specifically done a very special way and they all find life will satan basically in mice in the sense of what they're doing ruins these fears but this is back in two thousand sixteen as well. This was everywhere so thinking about the idea that this is causing an increase in chronic illness. And in with regarding your dna of all things we need to think about. How what this means going forward in this discussion again thinking about whether or not there is something that might be used in regard to spraying people all over the world. I want to reiterate a point that i made the other day. In regard to how long this has been possible here is a alistar allen speaking on the inevitability of smart dust. And i've played this a couple of times. Now i want you to listen again just to the first part understand that what he's discussing is something that was available in two thousand four as talking about smart dust. Now consider what that could be today and what they might be using it for today. We're still essentially the bagging. The ropes together stage for this sort of stuff..
Major League Baseball to hold first Lou Gehrig Day on June 2
"Garak joins Jackie Robinson and Roberto Clemente as players who are honored throughout the league I consider myself the luckiest man on the face of the earth June second marks the ninety sixth anniversary of when Gehrig started at first base for the New York Yankees in place of Wally pipp starting his record streak of consecutive games played June second was also the day in nineteen forty one Gary died at the age of thirty seven Amiot trophic lateral sclerosis or ALS I might have been given a bad grade but I've got an awful lot on June second each home team will have for a LS logo's in ballparks to mark Eric's number for money will be raised to fight ALS also called Lou Gehrig's disease I'm at Donahue
"lateral sclerosis" Discussed on WCBM 680 AM
"40% off and free camera today. On Wall Street stocks are rising to start this holiday shortened trading week. The Dow is up 268 points. The NASDAQ is getting 68, the S and P five hundred's increase his 26. The price of oil is up moving closer to 43 bucks a barrel in that is a reason gas hasn't dropped Maura with less demand in this covert crisis, one penny in the past two weeks. The new price is $2. 18 cents. It would have been wasn't a dime I believe. That's Children. Lundberg, who was an analyst who surveys gas stations nationwide. So does Triple A. It's national average for regulars to 11 per gallon. Did you take the ice bucket challenge several years ago. A lot of people did. And now, AH, year after one of the co founders died, the other has from the same disease. Those challenges raised awareness to fight back. Queen motivational speaker and co founder of the Ice Bucket Video Challenge for a less died Sunday morning at age 37. He battled India traffic lateral sclerosis, often called Lou Gehrig's disease since diagnosis in 2013 the video challenge taking social media by storm in summer, 2014. Quinn talking to Fox News radio in 2015. The disease that has no hope at the moment. But the Ice bucket challenge revamped that outlook, the challenge so far raising more than $250 million worldwide. Currently, there is no cure for LS a fatal progressive nervous system disease, which impacts nerve cells in the brain and spinal cord, causing loss of muscle control. And Kerik Fox News in the NFL. The L. A Rams play Tampa Bay tonight to close that week. 11 of the season last night. Kansas City beat Las Vegas on a last minute touchdown. Pittsburgh State Undefeated running Jacksonville and the New York Jets remain winless, losing to the L, A Chargers and in Cincinnati's lost the Washington Bangles star quarterback Joe Burrows substance Ian ending knee injury. I'm Dave Anthony. This is Fox News. The rain is moving out the dryer air moving it will turn out sunny for the afternoon. Sunny and a little bit cooler 52 Today temperatures at night drop into the lot of it. Thirties Beautiful Fall day tomorrow. Sonny and 52 We start to get the clouds Wednesday Wednesday warms up 58. Next storm could bring us some rain on Thanksgiving Day. I'm meteorologist Terry Smith from the Weather Channel for talk radio. 6 80 WCBS. I'm sure many of you realized the holiday season is the slow season for home improvements and peek custom remodeling. We're determined to keep all of our crews working and have jobs, installing every day to make sure our entire staff and our customers have a merry Christmas This year. We're having a one week Black Friday sale, taking 25% off the total cost of all roofing, citing window and door. Replacement projects. Mentally that we have no interest and no payments available through Christmas. 2022 has always piqued custom remodeling is.
Pat Quinn, Ice Bucket Challenge co-founder, has died at age 37
"J. Powers, Fox News Another co founder of the Ice Bucket Challenge, has died. Pat Quinn, motivational speaker and co founder of the Ice Bucket Video Challenge for a less died Sunday morning at age 37. He battled Amy a traffic lateral sclerosis, often called Lou Gehrig's disease since diagnosis in 2013 the video challenge taking social media by storm in summer, 2014. Quinn talking to Fox News radio in 2015 disease that has no hope at the moment, but The ice bucket challenge is revamped that outlook the challenge so far raising more than $250 million worldwide. Currently, there is no cure for a less a fatal progressive nervous system disease, which impacts nerve cells in the brain and spinal cord, causing loss of muscle control.
"lateral sclerosis" Discussed on Newsradio 1200 WOAI
"Eastbound at 2 81 direct nectar construction taking place since causing some minor slowdowns as you approach the area there. I'm Zach Bad news Radio 1200 Wook. I stay warm throughout the upcoming week we will see clearing skies dropping back to the Middle Upper fifties. X Files The sun Monday 75. You've got the clouds building in Monday night strata. Scattered showers of possible straight shower thunderstorm Tuesday. And 81. I'm Jeff, you know for the Weather Channel on San Antonio's official weather Station news radio 1200 W away. I You ever and another co founder of the Ice Bucket Challenge has died. Pack Quinn, motivational speaker and co founder of the Ice Bucket Video Challenge for a less died Sunday morning at age 37 he better the EMEA traffic lateral sclerosis, often called Lou Gehrig's disease since diagnosis in 2013 the video challenge taking social media by storm in summer, 2014. Quinn talking to Fox News radio in 2015 disease that has no hope at the moment, but The ice bucket sounds revamped that outlook the challenge so far raising more than $250 million worldwide. Currently, there is no cure for a less a fatal progressive nervous system disease, which impacts nerve cells in the brain and spinal cord, causing loss of muscle control boxes. And Carrick. Meanwhile, in sports, one of the embassies, bright young stars has agreed to a large contract extension. All Star Guard Donovan Mitchell and the Utah Jazz have agreed to a five year $195 Million Contra. Act extension, according to multiple media reports, the 24 year old Mitchell, the 13th overall pick in the 2017 draft, he immediately went on to win the Rookie of the Year award in his first season. Mitchell followed that up with a strong second.
Pat Quinn, Ice Bucket Challenge co-founder, has died at age 37
"And another co founder of the Ice Bucket Challenge has died. Pat Quinn, motivational speaker and co founder of the Ice Bucket Video Challenge for a less died Sunday morning at age 37 He better of India Tropic lateral sclerosis, often called Lou Gehrig's disease since diagnosis in 2013 the video challenge taking social media by storm in summer, 2014. Quinn talking to Fox News radio in 20. 15 disease that has no hope at the moment. But the Ice bucket challenge revamped that outlook, the challenge so far raising more than $250 million worldwide. Currently, there is no cure for a less a fatal progressive nervous system disease, which impacts nerve cells in the brain and spinal cord, causing loss of muscle control boxes.
"lateral sclerosis" Discussed on AM 1350 WEZS
"The latest when you need it on demand from Fox News and Amazon, Alexa Eight people were hurt during a shooting at the Mayfair Mall and Wauwatosa, Wisconsin Friday. The victims were taken to the hospital and are all expected to survive. The police announced Sunday that they have arrested a 15 year old boy, and I've also recovered the suspected firearm used in the shooting. The shooter exited the mall is other patrons were running out, unaware that the shooter had left the mall and a perimeter was established. Tactical teams were formed to begin clearing them all of patrons sheltering in place. While the toast the chief of police, Very Weber and another co founder of the Ice Bucket Challenge has died. Pack Queen motivational speaker and co founder of the Ice Bucket Video Challenge for a less died Sunday morning at age 37 he better the EMEA traffic lateral sclerosis, often called Lou Gehrig's disease since diagnosis in 2013 the video challenge taking social media by storm in summer, 2014. Quinn talking to Fox News radio in 20. 15 so disease that has no hope at the moment, but The Ice Bucket Challenge revamped that outlook, the challenge so far raising more than $250 million worldwide. Currently, there is no cure for a less a fatal progressive nervous system disease, which impacts nerve cells in the brain and spinal cord, causing loss of muscle control boxes. And Carrick. Meanwhile, in sports, one of the embassies, bright young stars has agreed to a large contract extension. All Star Guard Donovan Mitchell and the Utah Jazz have agreed to a five year $195 Million Contra. Act extension, according to multiple media reports, the 24 year old Mitchell, the 13th overall pick in the 2017 draft, he immediately went on to win the Rookie of the Year award in his first season. Mitchell followed that up with a strong second year before being named an All Star for the first time this past season and leading the Jazz to the playoffs, where they fell in seven games to the Denver Nuggets in the first round. Through three seasons, Mitchell has averaged 22 points, four rebounds and four assists. Fox's.
Pat Quinn, Ice Bucket Challenge co-founder, has died at age 37
"Co founder of the ice bucket Challenge for a less died this morning at age 37 he better Amy O Tropic lateral sclerosis, often called Lou Gehrig's disease since diagnosis in 2013, the ice bucket video challenge taking social media by storm in summer. 2014. Quinn, talking with Fox News radio in 2015 is great for the A L s community. We really needed a new sense of fight new sense of hope. So far, the challenge raising more than $250 million Worldwide.
Co-founder of viral ALS Ice Bucket Challenge dies at 37
"The Ice Bucket Challenge for a lesson. This morning at age 37. He battled Amy Oh traffic lateral sclerosis, often called Lou Gehrig's disease since diagnosis in 2013, the ice bucket video challenge taking social media by storm in summer. 2014. Quinn, talking with Fox News radio in 2015 is great for the A list community we really needed. A new sense of fight new sense of hope. So far, the challenge raising more than $250 million Worldwide. America's listening to
"lateral sclerosis" Discussed on CMAJ Podcasts
"Services respect services recommendations in place and When when when you mentioned about palliative care. I think we're palliative care services. Come in is. They're very important. Partner in in our treatment and management of our patients with with this disease and we have also recommended that palliative care services be considered really at any stage and that they should be considered throughout the disease course not just at the end of life Period for the patient palliative care physicians and teams and there's there's their healthcare professionals are trained in symptom management and certainly they should be introduced whenever there a severe physical psychological or existential distress. And we've worked with their palliative care colleagues in In order to ensure that our guidelines are addressing what they're able to provide and support our patients with and so to ensure that kind of integrated nudie of care. The palliative care services should be introduced before that advanced stage of the disease at end of life and they are often in a position particularly around. Respect care that can directly relate back to providing support services in respect for for those Family caregivers yet. This recommendation to involve palliative care earlier is certainly consistent with with what we're seeing in terms of their role across the board in in madison. I think Patients and families and often clinicians thought know palliative care comes in at the very end and obviously as you said they're experts and symptom management and engaging them earlier in the disease in in all kinds of diseases. Not not just us Is a really important thing to improve quality of care for for patients and for families for that matter. Gary you know we've covered a lot. This guideline is a lot of recommendations. We've covered a lot of them. But we have in this podcast. We've just tip of the iceberg I was really impressed by the breadth of the work that your group took on. Are there any other recommendations that you think are particularly important to mention at this time. Maybe kristin could you address that. There's a couple of other ones wanted to highlight it. What i'll just son mention briefly as well. Just because it's a canadian numb i because well and that's that we include exercise prescriptions within the guidelines as well that's not it's been another guidelines and it's a something that patients always ask about and there is evidence and exercise that can help with the progression of the disease and improve the progression. Also evidence that it can help with symptoms as well I shouldn't steal calling center. This is her baby beating his isis. And the colleen could expand probably on that further..
"lateral sclerosis" Discussed on CMAJ Podcasts
"I as at technology for communication has been incredible as just appropriately referring patients so that they can have access to that. Tip of communication tool is so helpful. It is also really important to be proactive. So if you're thinking a patient is going to potentially develop significant desserts. Such they lose their speech. You could consider for patient for voice banking so if they bank their voices and sounds they're able to make then when they do transition to a text to speech option then It could be their voices speaking on their behalf So just having those Patients and brockton. The communication is is so important thing that you asked about was condition and behavioral impairments so on. Nfl as it has been known for about Twenty years that It is not always just a motor disease. So although it's predominantly motor disease it is not solely always motor sees in about fifty percent of patients. There could be detectable cognition or behavioral changes and in about twenty percent of the population. There can be frank. Dementia that occurs. And that's super important to be able to screen those abnormalities because if there is presence of cognition behavioral impairment that could impact caregiver relationship with that patient frustrations at the home as well but also importantly having the presence of cognitive behavioral cairns doesn't fact on no sus which is obviously important for the patient family to be aware of and communication of their desires or decision making them up his eyes so having discussions about advanced care planning in the setting of Presence of cognition or behavioral. It's a super agent. Have as early as possible. How you manage commissioner behavioral impairments other than talking with conversations unfortunately so treatments So it is usually a multidisciplinary approach to managing the behaviors and discussing how to overcome some of the comes of impairments in mentioned caregivers. And obviously the pandemic. We've had a lot of focus in in the media on the role of caregivers particularly in in long term care and the and the stress on them. I know that you've made some recommendations directed for caregivers the caregivers and and their their health and their wellbeing and particularly around also the area of palliative care wondered if calling. You could tell us a little bit about some of the recommendations of for the care of caregivers And then particularly in the context of of care sure. Will i think one of the most important things is the fact that we have recognized caregivers. And that's something that's unique in this guideline and Perhaps a canadian Sentiment in terms of wheat. We try to think of everybody and and not forget those that that There may not be a lot of information from from a research point of view But we have as an expert group put together a a number of expert consensus statements with regards to caregivers and i think the most important is that we have to be attentive to the needs of these care givers. The physical needs the emotional needs as well as the impact that that this disease has on social emotional and financial functioning. It's it's a very expensive disease. It's it can be devastating to to patients and their families and so the multidisciplinary clinics need to be aware of this and address that financial strain on the caregivers and be prepared to provide.
"lateral sclerosis" Discussed on CMAJ Podcasts
"Inserted in a timely manner going to that timeline s interventions and we then made a point in these guidelines that we'd like the and tricia mention to be initiated within four weeks. If it has been suggested the other aspect is me would very much want to have the patients who have a feeding tube inserted Instead inserted by someone who has comfort and knowledge about a ls onto. Make sure if there's any respiratory insufficiency in these patients that they have adequate responders or around the time the insertion so that amorality videon patient isn't compromise insertions. Well you've mentioned several times. The the notion of expertise So patients with us. They require expertise. They require multidisciplinary care. So i'm given particularly canada's geography. How should this care be delivered. You know rural versus urban settings came to tell us a little bit about that. Sure this is colleen coming coming from a province that is I guess he could. Many of our cities would actually be considered rural when you compare it to some of the larger more central parts of the country but We we have in our guideline I think some of the best evidence actually is around the multidisciplinary care and so this is a team based care. That prospectively follows a patient through the continuum includes not just the physicians but various things. It's speech pathology psychological support respiratory therapy as well as addressing psychosocial issues and and end of life care and patients who are followed in these multidisciplinary care clinics with that s Specialized care have been demonstrated to have improved survival. They have fewer and shorter hospital. Admissions they actually are are have reports of of better quality of life in some of this may relate to They're better compliance and up. Take of important intervention. Such as the disease modifying therapies the feeding tubes that kristen mentioned as and the national ventilation that i reviewed now we have also very unique to our guideline have have indicated that telemedicine and tele help options are feasible and can be used to supplement these specialized clinics that would be otherwise done in person and there is some evidence to back that up as well and so for patients not just in rural settings or remote settings but patients when they get to a stage in their illness where travel becomes quite burdensome in difficult. This may be due to inclement weather or the stage at which there at for for mobility or the support needed for instance just for the simple fact of getting in and out of a vehicle and traveling to to a clinic. Outside of the home might represent significant challenges. So we're strongly recommending that that telemedicine and telehealth options be be considered an explorer to help optimize patient accessing care. And that all patients Should be referred to. What did the multidisciplinary aol specialized clinics and there are these clinics throughout every province in the country and In in areas where they a patient may not be able to to travel telehealth intel. A rehab options are certainly viable. Covid has really been able to provide us with an accelerated acceptance and support for doing telehealth and telemedicine. So it's one of the positives that's occurred because of this. This pandemic is that it's forced many institutions now and health facilities to adopt and support and get provincial. Buy in from from payers such as medicare systems to support.
"lateral sclerosis" Discussed on CMAJ Podcasts
"Important role for routine and frequent monitoring of respiratory symptoms every three months or at any time. There's a major clinical change. We need to screen and evaluate patients respond tori function and we do that by looking at symptoms and with sporadic matry. It's important for physicians to realize that patients do not need to be seen in a specialized sleep lab that sporadically tree. That is important for ls can be managed by bedside sporadic retreat and simple night ox symmetry and above all were. We rely heavily on their symptoms. If a patient is symptomatic for respond tori insufficiency. They should be started on non invasive ventilation and non inventively base ventilation can be delivered With with devices and even set up at home or local clinics depending on your region and their regulations But noninvasive ventilation can be done with bypass sheen's with volume cycled ventilators as well as I in some cases you can use a cpap machine. But we were more encouraging the bypass or or ventilators that can see a patient through a longer duration of their illness. A change in the canadian guidelines from other guidelines is an earlier indication for initiating noninvasive ventilation previous guidelines have reported using on at a f v c or forced vital capacity at fifty percent but we're recommending at sixty five percent even in the absence of symptoms. The evidence supports the earlier. We intervene even. If patients are able to comply with this intervention for as little as four hours a night that will confer a benefit. We strongly are stating that. This needs to be done in a timely manner and we've actually put put timelines that within a referral for initiation of noninvasive ventilation. They should be started within four weeks. and this is something that will allow us to benchmark that those treatments and advocate for those resources we also in our guideline review Other areas of spark tori function. That are incredibly important for patients suck quality of life and symptom management. This includes airway clearance. So this is keeping your airways Cleared of secretion and there are a variety of interventions such as using lung volume recruitment and mechanical inexa. Flation one of the unique things that we have in our canadian guideline as well introducing the concept of having in-home supports with respiratory therapists for problem solving and for proactive following in as well we've introduced the intervention of of mouthpiece of ventilation as an option for our patients. We're gonna be talking a little bit later about palliative care. But i think one of the things that struck me on the ventilation ventilation recommendations that you mentioned that advanced care planning discussions should include discussing these interventions and allies including the option of removing treatment. That's been initiated that that it's a really important point in it's something that's a little opposite with our patients. Have people get very usa sort of advanced care planning and having these do not resuscitate orders but in fact many of our patients with a will already have these interventions in place because they are helping to prolong survival. They're improving quality of life. They're managing their symptoms and so for most of our patients talking.
"lateral sclerosis" Discussed on CMAJ Podcasts
"But the interesting thing about this drag. is that It it is not affected demonstrated across all patients prevail us. It was only restricted patient population on such as those patients that are relatively at the beginning of their disease and you not have made significant fire terrain enrollment at that point in time that demonstrated improvements with this medication. The agreement demonstrated was slowing the progression of disability with meeting with patients so in the appropriations meaning those patients that on the criteria for inclusion not for the clinical trial demonstrated efficacy. It is the appropriate treatment. You offer these patients. Tricky thing about the this therapy though. Is that an intravenous therapy and it has. It's really interesting and unusual treatment regimen whereby there's a loading period where they get a daily infusion over an hour or fourteen days in a row then they get two weeks off and then they go into repetitive cycles where they get ten of fourteen days of business in eastern time to and again and other fourteen days into exhau- so for patient to accept this therapy they have to Assume quite a bit of alteration in their like schedule because they'd have to get an ibm fusion Quite frequently Medication on so that was obviously significant..
"lateral sclerosis" Discussed on CMAJ Podcasts
"Amount of information because they could be overwhelmed. If you've delivered information to them at once so it's so important so when a physician is tasked with delivering the diagnosis to a patient that they have the time so Non interrupted non rushed time to discuss the diagnosis of the patients. To begin with the next is to be able to read the patient and understanding college information. They want to receive. You do not need to give everything to the patient and particular we on the guidelines talked about five noses. It is not necessary to talk about prognosis at the diagnosis. A patient does not need to know what kind of timeframe they have in front of them on one. You don't always know the answer to that and so it's always good to read the trajectory that the patient is on some of the other aspect about diagnosis to make sure that inches are seeing in time. Manner obviously a patient who is my physician physician or potentially humidity on neurologist who was concerned that patient in front of them has a s that patients going to need to be seen in a very timely manner. To make sure there is not obstruct there living rich and to be able to make sure that patient is aware of what treatments and be given.
"lateral sclerosis" Discussed on CMAJ Podcasts
"I'm dr diane kelsall consulting editor for same. Aj today in speaking with. Dr chris can choose. Smith and dr colleen o'connell who are two of the authors of a clinical practice guideline on the management of ls. This evidence based guidance is published in cma j. I've reached kristen in london ontario and calling in fredericton new brunswick to discuss welcome to both of you. Thank you so much for joining me today. Thank you very much led to be before we sort of launch into the guidance in this guideline which is i know was a monumental effort. Can you tell me a bit about who you are. I'll start Christians houston. I'm the medical director of the motor neuron diseases clinic in london ontario and armor is us but i also do other neuromuscular diseases as well. And this is colleen. And i'm as as you mentioned in fredericton new brunswick i'm actually a specialist in physical medicine and rehabilitation and i work at the provincial. Neuro rehabilitation center stand cassidy center for rehabilitation in my practice is predominantly in addition to a ls and other motor neuron and neuromuscular diseases. I work in traumatic spinal cord injury and brain injury so calling. Let's start with you How much people in. Canada have ls and what are the most common symptoms sure al s even though most people consider it and we do think of it as a rare disease. It's actually one of the more common neuro degenerative diseases of middle age at any one time. There's probably about three thousand canadians. Who are living with the with the disease. One of the hallmark findings is what we call progressive muscle weakness often. That is painless. It can start in any region of the body. Most commonly it starts in a single limb. Are there an arm or a leg but it can also start with bulb our involvement which would cause disarm three air dysphasia and it's generally progressive and for all patients at some point in fact almost eighty percent of all patients will die from respiratory related failure so there are more people than people might think actually have ale s So i'm going to sort of move onto another question which is connected given the number of people why is there a need for this guideline but at this particular time wonder if you could answer that one kristen. So canadian alice nations have been talking about developing vilain for probably over a decade..
"lateral sclerosis" Discussed on KFI AM 640
"To July, but US employers still added 1.4 million jobs. National unemployment during the pandemic peaked in April. At 14.7%. Sauron's watching a car fire on the 60. That's what found side in Rubido Approaching Valley Way. Looks like they just credible to extinguish this fire and clear it from the two middle lane and it's cleared after the shoulder, but it's still causing a 20 minute delay from Market Street now heading to crash in Ontario. This is on the 10 westbound just after at a Wanda to crash walking to middle lanes. Their trip comes to almost a complete standstill after you pass. Find this guy is sponsored by injury. Attorney Superwoman super lawyer dot com Jeff all with more on the 60 way don't need fires in this weather, that's for sure. Indeed, the section I'm talking about now is the West 16 between 657 10. Coming through Monterey Park at around Garfield Wilcox. All that on the downhill side, It was quite a problem in the right lane for a long, long time. I watched it clear just minutes ago. All lanes open my fact that went to the shoulder area around the planet. So it's just gonna be a little flow from Rose beat Boulevard again up over that hill. And then once you get going over towards 17, it'll be okay. Little sloth of the East. L A interchange but kind of normal stuff. Eastbound drivers. Good all the way out. And, uh, well going through the east l a interchange in all directions out. Everything going in and out is okay. No crashes. All lines are open. Injured in an accident visit Superwoman super lawyer dot com Jeff Bark a F I in the sky. Can't find the sky. Help get you there Faster of Sauron Crump, this hour of the Bill Handel Show brought to you by normal Reeves. Honda Superstores Norm Reeves honda dot com Experimental Medication has shown great promise in slowing the progression of my traffic, lateral sclerosis, or According to research published this week in a random double blind protocol patients who were given the medication maintained higher scores on assessments.
"lateral sclerosis" Discussed on 710 WOR
"Asleep let me just say that lateral sclerosis cancer cerebral policy Crohn's disease cerebral palsy that is not policy cystic fibrosis epilepsy fibromyalgia by the way Morgan Freeman has that problem yeah intractable headaches syndromes multiple sclerosis Parkinson's disease the Michael J. Michael J. fox disease and on and on and on are all part of the twenty nine agreed to for adult yes and then among kids there's eight of them well ask yourself the question by the way what's what's left out well cancers left out crowns is left out my grades left out so if I have a child with Crohn's migraines are cancer in the state of Connecticut I can't get product but I found over eighteen and I have those three diseases I can't get product I'm sure that makes sense to somebody I'm just not sure who there is not a lot of news in Massachusetts so I've decided to make some predictions in two thousand and twenty in the Commonwealth state my top five first frustrations over the lack of equity it will boil over there's just no other way to say it despite a lot of talk well crafted policies on paper and good intentions Massachusetts has very little to show so far for its efforts to create an equitable cannabis industry that reflects the racist reality of the historical war on drugs as of mid November just six of two hundred twenty seven licenses granted by the cannabis control commission had gone to entrepreneurs in the states social equity and economic empowerment programs the rest of the sector is dominated by larger multi state operators second prediction big pot companies will engage in alcohol industry style pay to play tactics in two thousand and nineteen big cannabis was trying to control seemingly independent retailers through onerous loans and management agreements unsuccessful attempts to bypass the state's three retail license gap in two thousand twenty I predict we'll see many attempts by larger players to arrive at the same end which is retail domination by different means specifically a supply agreement with so called pay to play clauses imagine this your own independent marijuana retail shop that doesn't grow a manufactured some products have grower come see you and says Hey all wholesale you a bunch of flour at a steep discount if you dump those products you stop all of our competitors right this exists in all of consumer packaged goods regardless of its food drug master convenience stores is that not right check yeah I mean this is a this is the nineteen seventies all coming back right so this is classic right so a lot of large consumer packaged goods companies used to try to flex their muscles with all kinds of programmatic work a cruel programs and other things that said the more SK use the more stock keeping units the items are flavors that you carry of mine the more money you will make on every case well that benefits large companies to the disadvantage of small companies who get quote elbowed out of the way all right let's move on third prediction anti cannabis driving legislation will pass but the state legislature won't do much else on marijuana as the marijuana market gets bigger and the advent of the livery and social consumption businesses inch closer in Massachusetts proponents of tough anti cannabis driving measures like the one proposed by Charlie Baker the governor will continue to accumulate ammo and momentum I think the state Senate will insert some modest revisions aimed at placating civil rights groups but Baker will more or less get his bill through and call it a win for public safety for production the lab backlog will become a serious problem operators are already grumbling about growing wait times at the state's only to lab their license the test recreational products if more art approved soon and additional suppliers continue to get licenses the problem will get even worse imagine that as a back log right it's like a pipeline everybody's trying to get in and if you were getting through right consumers will start to take notice when their favorite shops start opening openly blaming the lab shortage for lack of products on the shelf and what does that do well perhaps that sense of the black market right predictions C. B. D. will remain a model the state and federal government will continue to drag their feet and developing regulations for edibles containing have driven CBD much to the consternation of license local help farmers who are watching their crops rock while unregulated product proliferate at gas stations you understand what I'm saying right so the state of Massachusetts said yes we're in support of C. B. D. yes for support of hemp okay I'll go the farmers they produce the help they change their farms over from whatever corn tomatoes what have you selling it for fifteen thousand Isshin acre that would be good and they converted over to hamper they thought they were gonna make thirty five thousand acre that would be better right left thoughts on that thirty five better than fifteen way better you're done right it is all right then guess what happened can sell it right there you go also thanks jae so then what happens is they put Ichabod on C. B. D. sales I know how to be able to vape in other things so what's happening now farmers can't sell it and then what's happening well perhaps some bankruptcies I've seen any number of farmers in western mass were having nothing but problems all right there you have it ladies and gentlemen my thoughts on the critical issues in the tri state plus my predictions of Massachusetts when we come back we'll move on to our next segment study an amazing facts right after the.
"lateral sclerosis" Discussed on KTOK
"Atrophic lateral sclerosis or a LS the disease that he was diagnosed with back in twenty eleven the former special teams standout is regarded for his blocked punt leads things to win their first game back in the Superdome following hurricane Katrina Louisiana senator bill Cassidy who led the push for this honor for Gleason worked with the congressional gold medal committee on the metal design featuring police in a Saint's Jersey with images of a mountain and forest paying homage to his native state of Washington boxes battle publicado but Jack Callahan this is fox news from the news radio one thousand Katie okay weather center and the four warn storm team cloudy overnight the lower forty eight partly sunny on Wednesday with a high of fifty five in a cold front comes through on Thursday cloudy we have a seventy percent chance of rain and a high of forty three on Friday a ninety percent chance of rain and a high in the mid fifties from the K. T. okay weather center and the four warn storm team I'm Beth Myers you can hear Katie okay online with the I heart radio I sponsored by Travis Watkins tax firm I arrest problems no problem call or text four five one thirty four twenty one can stacks firm dot com during protect your child streams by keeping them healthy if your son or daughter is age eleven or twelve the American cancer society recommends giving them the HPV vaccine to help prevent HPV cancers later learn more at cancer dot org slash dream big the drive every weekday afternoon at five one one thousand Katie okay and again that's what on need the we have a has some for in every way and for that's how you that for then there are two premiere networks presents coast to coast AM with George nori the first astronaut for the United Kingdom Helen Sharman says that aliens exist now did she mean little organisms.
Last Fundraising Plunge for Ice Bucket Challenge Inspiration
"News today marks the end of a frigid and very successful fundraiser heat Freddy's battle with Lou Gehrig's disease helped inspire the ALS ice bucket challenge supporters taking one last chilly plunge for the former college baseball player the phrase family says Saturday's annual plunge for Pete a good harbor beach and Gloucester Massachusetts is the last the former Boston College baseball player lived in Beverly a suburb north of Boston he died December ninth after a seven year battle with a alas or any atrophic lateral sclerosis the ice bucket challenge went viral in twenty fourteen raising more than two hundred million dollars for
"lateral sclerosis" Discussed on This Week in Science
"All right ready to move on. Okay, jump into. The interview are interviewed tonight is with Dr Chris Donnelly. Dr Donnelly is an assistant professor in the department of neurobiology at the university of Pittsburgh's of medicine, and he's the scientific director of live like Lou center for research in the university of Pittsburgh brain institute. His studies are focused on the biology underlying neuro degenerative diseases with a particular interest in understanding neuronal death of served in amyotrophic lateral sclerosis ale s and frontal temporal dementia. F- TD, Chris welcome to the show. Wonderful. How are you? Good. I'm good. I'm good. Are you? I would love to know. So many of us have heard about a LS either. Because of people that we know or be I mean social media's used as in a couple of years ago. The icepack challenge was a massive social media effort to raise money for ale research, but can you give us some insight into how you got interested in studying, this particular particular disease. Yes. I I was got interested nail smile is like fifteen years old. In fact, we had been assigned to read a book called Tuesday's with Maury in high school. And it was it was just something we had to do for an English class. And at the time, I didn't know it was I don't think it was very well known at the time either. And I just read about this person who went to visit a mentor of his sort of biographical story and chronicled how this person presenter sort of went through the disease progression eventually passed away from it. And as a fifteen year old kid who didn't understand mortality. I don't think it's time. It was very frightening in, you know, as I've kinda continued might might research my scientific career just like education. It was always something that I was really interested in. But didn't really get into until after I got my PHD as related. Yeah. In so you I mean your work has gone from like stem cell focus to being specifically like protein focused. Can you a little a little overview of that you have? Yes. So you're speaking to someone who is like one of those people who had multiple majors in college is never figure out what they wanted to do. But always. Yeah. Just always like biology, sorta ended up sticking with it had a really great mentor who was in grounded grad who was each me about DNA and DNA epigenetics, and how it opens and closes, and you can open read certain genes, and she got me interested in molecular biology suggested I go to graduate school where I studied like nerve regeneration after an injury, but really looking at like molecular side of things and then at that point after I was kind of finishing up the opportunity to finally get into a less, and then when works entering under some experts Johns Hopkins. And that sort of my personal history. But ally was there that's when I learned all about stem cells and how we could use these models disease. But. How can you use them as a model for? I mean, how'd you just a cell, and and go this is what we learned from. Yes. These these nerdy generative diseases. The major problem is we don't know what causes them. So how do you study them in the first place? If you don't know the cause, you know, you can't it's not like a tumor. Can't really do. I op see like you can with some cancers. So. You know, when these induced for stem cells technology that was developed in you know, sort of early MSCI thousands, and is technology basically was able to reprogram these skin cells or blood cells and kind of tripped on into becoming embryonic like any kind of trip them into going into development.