10 Burst results for "Lapenne Aveer"
"lapenne aveer" Discussed on UN News
"Death in patients infected with new corona virus, the Solidarity Therapeutics Trial, overseen by the world. Health Organization who found that REMM disappear hydroxy chloroquine, Lapenne Aveer. Rootin- and Interferon. appeared to have little or no effect on twenty eight day mortality or the hospital course of covid nineteen among hospitalized patients. The study involved more than thirty countries and investigated the effects of the treatments on mortality ventilation and length of stay in hospital. It did not examine other uses of the drugs such as preventive treatment, which would. Require further trials in a related announcement. The WHO said that Covid nineteen had also highlighted the increased vulnerability of people with high blood pressure to the coronavirus. The warning is based on data for more than one hundred twenty countries showing significant caveat related disruption to treatment for people suffering from chronic health conditions with findings showing these patients make up fifty to sixty percent of all deaths through covid. Dr Bent Mickelson director of WHO's Department of noncommunicable diseases said that more than one point one, billion people around the world suffer from hypertension mainly in low and middle income countries when it comes to call it nine, thousand, nine, hundred, hypertension, one, hundred and twenty two countries that has reported. US that in over fifty percent of the country's the healthcare services disrupted fully or partially fifty percent of the country's, and in addition we see a high number of is we don't have global figures yet, but we see in the rain show fifty, sixty percent of the people that are severely ill and died in hospitals from code have hypertension diabetes, and so forth and the working on the global targets. An airlift of hope agreed by Yemen's warring parties to return more than one thousand detainees to their families has been welcomed by U N Special Envoy Griffiths, whose urged both sides to agree to further peacebuilding measures in a briefing to the Security Council on Thursday Mr, Griffiths confirmed that the extraordinary operation had begun in line with an agreement reached last month in Switzerland between the government of Yemen and Hootie opposition representatives although the prisoner swap which continued on Friday will bring immense relief and comfort to many. Families said the veteran you negociator. He noted that it does not include many thousands more Yemenis detained during the course of this conflict likely numbering. Some fifteen thousand while appealing for further prisoner release talks the UN special envoy also called for face to face meetings between the warring parties so that they can agree on a joint declaration to end more than five years of catastrophic fighting. If agreed, the development would prepare the ground for a nationwide ceasefire economic and humanitarian measures and the resumption of the political process. Hate speech has no place in this. Sunday's general elections in Bolivia you're in high commissioner for Human Rights. Michelle Bachelet said on Friday in an appeal for a peaceful and inclusive national poll Misbash let urged Bolivia's authorities political and other actors to refrain from any actions that could spark a repeat of violent political clashes over the disputed election. Last year that left at least thirty people dead and more than eight hundred injured. The High Commissioner expressed serious concern at inflammatory language and threats made in recent weeks as well as. An increasing number of physical attacks. I welcomed the Bolivia in people's determination to participate in the elections. Miss Bachelet said in a statement she added that the elections represent an opportunity to move forward on social and economic fronts and diffuse the extreme polarization that's been plaguing Bolivia in recent years. The UN Human Rights Office deployed mission to Bolivia in November twenty, nine, thousand, nine it remains in the country to monitor and report on any human rights violations and abuses including in the context of the elections Daniel, Johnson, U. N. News..
"lapenne aveer" Discussed on UN News
"Results from a UN coordinated international trial looking at four cave nineteen therapeutics have shown little or no positive impact on preventing death in patients infected with new corona virus, , the Solidarity Therapeutics Trial, , overseen by the world. . Health Organization who found that REMM disappear hydroxy chloroquine, , Lapenne Aveer. . Rootin- and Interferon. . appeared to have little or no effect on twenty eight day mortality or the hospital course of covid nineteen among hospitalized patients. . The study involved more than thirty countries and investigated the effects of the treatments on mortality ventilation and length of stay in hospital. . It did not examine other uses of the drugs such as preventive treatment, , which would. . Require further trials in a related announcement. . The WHO said that Covid nineteen had also highlighted the increased vulnerability of people with high blood pressure to the coronavirus. . The warning is based on data for more than one hundred twenty countries showing significant caveat related disruption to treatment for people suffering from chronic health conditions with findings showing these patients make up fifty to sixty percent of all deaths through covid. . Dr Bent Mickelson director of WHO's Department of noncommunicable diseases said that more than one point one, , billion people around the world suffer from hypertension mainly in low and middle income countries when it comes to call it nine, , thousand, , nine, hundred, , , hypertension, , one, , hundred and twenty two countries that has reported. . US that in over fifty percent of the country's the healthcare services disrupted fully or partially fifty percent of the country's, , and in addition we see a high number of is we don't have global figures yet, , but we see in the rain show fifty, , sixty percent of the people that are severely ill and died in hospitals from code have hypertension diabetes, , and so forth and the working on the global targets. .
COVID-19: ‘little or no’ benefit from remdesivir: WHO
"Results from a UN coordinated international trial looking at four cave nineteen therapeutics have shown little or no positive impact on preventing death in patients infected with new corona virus, the Solidarity Therapeutics Trial, overseen by the world. Health Organization who found that REMM disappear hydroxy chloroquine, Lapenne Aveer. Rootin- and Interferon. appeared to have little or no effect on twenty eight day mortality or the hospital course of covid nineteen among hospitalized patients. The study involved more than thirty countries and investigated the effects of the treatments on mortality ventilation and length of stay in hospital. It did not examine other uses of the drugs such as preventive treatment, which would. Require further trials in a related announcement. The WHO said that Covid nineteen had also highlighted the increased vulnerability of people with high blood pressure to the coronavirus. The warning is based on data for more than one hundred twenty countries showing significant caveat related disruption to treatment for people suffering from chronic health conditions with findings showing these patients make up fifty to sixty percent of all deaths through covid. Dr Bent Mickelson director of WHO's Department of noncommunicable diseases said that more than one point one, billion people around the world suffer from hypertension mainly in low and middle income countries when it comes to call it nine, thousand, nine, hundred, hypertension, one, hundred and twenty two countries that has reported. US that in over fifty percent of the country's the healthcare services disrupted fully or partially fifty percent of the country's, and in addition we see a high number of is we don't have global figures yet, but we see in the rain show fifty, sixty percent of the people that are severely ill and died in hospitals from code have hypertension diabetes, and so forth and the working on the global targets.
"lapenne aveer" Discussed on UN News
"This is the news in brief from the United Nations further evidence of the unprecedented impact of Covid nineteen jobs has emerged in a new study by the UN Labor Agency which on Wednesday said that more than one in six young people have stopped working since the pandemic began. Those young people who still have a job have seen their working hours cut by twenty three percent said the head of the international organization. Ilo Guy Ryder who also urged governments to conduct widespread corona virus testing and tracing of relations to help get economies back on their feet countries. Such as the Republic of career and Iceland had invested ineffective virus hunting techniques which had cost less than one percent of their economic output developing countries. Where most people worked in the informal sector should be helped to do the same. The ALO Director General said we have to be very concerned about this coincidence of strongly useful populations high inform of economies limited capacities for testing tracing and want to call it the perfect storm but it is a combination of circumstances which I think combine to lead us to this concern that labor market outcomes could be particularly damaging and long lasting according to the workers in the Americas have suffered most from the economic fallout of the pandemic in terms of working hours lost since April thirteen point one percent followed closely by Europe and Central Asia. The decision has been taken to temporarily. Halt the use of hydroxy chloroquine as a trial treatment for people suffering from covid nineteen the UN World Health Organization who has announced development follows scientific reviews on these safety and efficacy of the antiviral against the coronavirus hydroxy. Chloroquine and chloroquine are accepted as generally safe for use in patients with autoimmune diseases or malaria. Who noted one study published in The Lancet Medical Journal last week? Found that among one hundred thousand patients. The drug was linked to high mortality and more irregular heartbeat. A final decision on the use of hydroxy chloroquine is expected in mid June. Who said in a statement experts will base their thinking on evidence from the? Who's international solidarity? Trial involves dozens of countries and thousands of patients along with other ongoing trials around the world in a statement. Who noted that patients already enrolled in the hydroxy chloroquine arm of the solidarity? Trial will continue taking the drug until they finish the course of treatment. In addition to hydroxy chloroquine three other anti-viral drugs have been selected as possible treatments for Covid nineteen they include Rendez Severe Lapenne aveer return aveer and Lopiano Vera Tanovic with Interferon Beta one. A finally to the U. N. Working Group on discrimination against women and girls whose independent rights experts said Wednesday that some. Us states appear to be manipulating the COVID nineteen crisis to curb access to abortion. In a statement the panel said that Emergency Corona virus orders suspending procedures not deemed immediately medically necessary had been used in Texas Oklahoma Alabama Iowa. Ohio are Kansas Louisiana and Tennessee. It was be regretted that these states which had a long history of restrictive practices against abortion appear to be manipulating the crisis to severely restrict women's reproductive rights said Elizabeth Broderick Working Group Vice Chair. The working group which was established by the Human Rights Council in September. Twenty ten insisted that access to abortion services was crucial during the pandemic as women grappled with new restrictions on them ability to quarantines and lockdowns Daniel Johnson U. N. News..
"lapenne aveer" Discussed on NEJM This Week - Audio Summaries
"In the hydroxy chloroquine group were excluded from the analysis of factor that potentially biases the results a case series showed high rates of viral clearance and clinical improvement in patients treated with hydroxy. Chloroquine plus Zithromax Jason However both studies had substantial methodological limitations including a lack of adequate comparison groups. A small randomized trial showed no significant difference in SARS covy to clearance or the disease course between the hydroxy chloroquine group and the Control Group results from additional studies are currently available as non peer reviewed. Prince one small trial for which important details are not yet available. Showed a modest improvement. In the group that received hydroxy chloroquine as compared with a control group whereas other studies did not show increased viral clearance or clinical benefit with hydroxy chloroquine steady limitations preclude definitive conclusions safety concerns with hydroxy chloroquine and as three mice include the potential for q t C. prolongation which is greater when both agents are used together a study in which patients received high dose. Corcoran was stopped because of a trend toward excessively high mortality determination of the role of hydroxy chloroquine with or without as throw mice in for the treatment of cove nineteen hinges on the results of well conducted clinical trials the FDA has issued an emergency use authorization easy way for the use of chloroquine and hydroxy chloroquine from the strategic national stockpile for the treatment of hospitalized adults with Kovic national team but this action does not constitute FDA approval of these rights for this indication the EU way encourages the conduct of and participation in randomized control trials to provide evidence for the effectiveness of these drugs for the treatment of Kovic. Low Pin. Aveer Retana Vir Lapenne Aveer Ritonavir an HIV. One protease inhibitor has been proposed as a treatment but it is not known whether drug levels adequate to inhibit the stars covy to produce as can be reliably achieved in people with Kovac nineteen. Who received this medication? In an open label randomized trial involving one hundred ninety nine hospitalized patients the addition of Lopin of your return of air to standard care did not result in faster clinical improvement or brisker drops in SARS covy to are in a levels at this time. Most experts advise against the use of low of your return.
"lapenne aveer" Discussed on Can He Do That?
"Before we get into the reasons why president trump has chosen this particular drug to put his faith in tout publicly. I wanted to understand how drug approval works and how hydroxy caloric fits into that picture. It turns out to no one's surprise. Clinical trials are complicated process. Dr Mark Gladwin is the chair of the Department of Medicine at the University of Pittsburgh Medical Center. He's also a pulmonary and critical care specialist. Dr Gladwin started by explaining the process for developing new drugs under normal circumstances so normally. There's a very long approval process for medications that that involves sort of the backbone science of whether a drug is likely to work off in the early process begins with models and how they drugs might work whether it's everything from computation in Salako modeling of a molecule protein interaction to a high throughput chemical screen of an action of medication and if those models pan out scientists bring their tests to life than these either small molecules are. Antibodies are taken to oftentimes animal models of disease a rodent models of disease typically NAS models success. There means the trials move on to safety untypically. There's two species of safety testing and this might be Dosing to a very high dose of a drug to make sure it's safe and then after going through extensive animal safety we go to what are called phase one trials where we look at whether it's safe typically paid normal volunteers and there again is a dose escalation to determine the maximum tolerated dose in humans after safety testing. Something called a phase. One to study where we're going to look at safety and patients may be with a particular disease and we might at that point. Look at preliminary advocacy. After that we go to larger phase two trials of efficacy in other does the drug work for a specific clinical endpoint. And there's one more face before a drug moves from clinical trial to review by the Food and Drug Administration. We go to phase three which are very large placebo controlled trials. Okay so you've laid out the process for trials of new drugs but what happens with drugs that already have. Fda approval for other uses the way that Hydroxy Clark Windows for example in this type of situation we can go right to a phase one two or phase three study where we immediately tasks whether the drug works for a new clinical indication. It's also important to note that for drug hydroxy Corcoran were allowed to use these drugs as clinicians were allowed to use these drugs off label. Meaning we can try them for a new indication. Even though they haven't been proven to work for that indication and that's what's happening internationally with hydroxy chloroquine for Kovac nineteen so then an emergency times like we're in now how do some of these processes change. We have support built into our system to expedite certain treatments. In Times of crisis there are two approaches in a time of crisis. And I know we're talking about hydroxy chloroquine or other experimental therapies for Kobe. Nineteen and physicians often have to extrapolate clinical information. Either from the use of a drug for another indication. Maybe there's very preliminary data that suggested. Drought might might work. Sometimes there's really only theoretical data that a drug may work and physicians than have to make an informed decision about whether to try that drug for a a new disease or a new indication and again. This process is called off label. Use The off label. Use of drugs is not something new. But it's something that's often done and I think in times of emergencies with emerging diseases. We tend to do that more so than as you said. There are two ways to expedite testing of drug for a new US. One way is by doctors just directly prescribing drugs to patients off label and then the other is by having patience formerly participate in a clinical trial where scientists can men draw conclusions about the results. Obviously for some patients time is of the essence. So how long does a clinical trial like this usually last so a traditional clinical trial can often last a long time? These trials may involve multiple countries hundreds if not thousands of patients and it take a long time to identify patients with the right inclusion and exclusion criteria seek out informed consent enroll patients and then analyze the data and complete the trial. That's that's actually wants to trial starts. You can imagine. The average. Clinical trial can take a year to seventeen months to even go through the regulatory process to start so a large phase two or phase. Three trial can often take as long as three years to start and complete. So then how during these times are we able to see much more? Expedited clinical trials in the case of Kobe. We are using drugs that have already been. Fda approved so it's quite easy to jump over the animals safety. Jump over the human phase one and go right to the clinical trial does drug work and so people are getting approval from local irbe's or multi-centre irbe's by the way the I. R. B. Is a review group that determines whether a clinical trial is a safe whether the monitoring's appropriate whether there's a scientific justification for the trial and the IRBE will monitor during the trial to make sure that we are safeguarding. The interests of our patients trial. We've found just a here. At the University of Pittsburgh Medical Center that are have turned all their attention in their priority to new research and treatment surrounding cove in nineteen. And we're seeing this really across the country and I think internationally there has been a priority placed on this so when we put in a proposal we have rapid approval. In fact one great example is if you want to try and new drug and you want to register the trial. The FDA provides something called A. N. D. which essentially is an investigational status for that drug or that treatment that you're trying and the FDA has has done something very innovative and very forward thinking for the case of convalescent plasma. This is a blood product. This would be the serum plasma from our blood and we would collect that plasma after we've been infected with SARS covy to. We've developed antibodies and now there's plasmas called convalescent. Plasma and our plasma now is loaded with antibodies that have the potential to bind to neutralize the virus and so the FDA provided across the board. I indeed for the use of convalescent plasma in clinical trials for patients with cove in nineteen. All right I wanNA pivot a little bit just to talk specifically about Hydroxy Clark. When can you just explain what this drug is? And what is typically used for so hydroxy? Chloroquine is an old medication. It has anti inflammatory properties. It has some anti parasitic properties targeting. The malaria parasite and it's thought to have some antiviral properties. It's used to suppress the immune system in the setting of patients with autoimmune diseases. It's chronically used and we know it has a very good safety profile so so that's sort of a little bit about what the drugs currently used for. So what's happened now is people have fought. Maybe this drug would work for SARS covy to infection and there's been use of it extensive use of it off label for that new indication and again there's very little data on the advocacy in other words. Where whether it works or not for infection with SARS covy to there have been a handful less than a handful of clinical trials that have many weaknesses for example either no control group or imbalances between the treatment and the Control Group and it leaves us very uncertain whether the drug actually works. Then why is it that during these times? We're hearing so much about this particular drug. I think hydroxy chloroquine. It's been rapidly embraced because there is a real hunger in need to offer something For patients with infection if you look at the very short history since December of cove in nineteen. We've already gone through two drugs that everyone was excited about and they didn't work the first one was a drug for. Hiv called Ritonavir Lapenne Aveer. There was a lot of people in China and Italy were given that treatment and then a trial showed that it didn't work the second one even more concerning was high dose steroids. These were used in China and also used in Italy and we now know that high dose steroids worsen the course of Kovic nineteen disease so already the first two drugs we pulled off. The shelf.
"lapenne aveer" Discussed on Coronavirus Daily Briefing
"Treatment. <Speech_Male> Ritonavir <Speech_Male> Slash <Speech_Male> Lapenne aveer <Speech_Male> a combination <Speech_Male> drug used <Speech_Male> to treat HIV <Speech_Male> infections <Speech_Male> and Ritonavir slash <Speech_Male> low <Speech_Male> pin aveer plus <Speech_Male> Interferon <Speech_Male> Beta Interferon <Speech_Male> Beta is <Speech_Male> a molecule that helps <Speech_Male> regulate inflammation <Speech_Male> in had <Speech_Male> positive effects <Speech_Male> on marmosets <Speech_Male> infected with Murs <Speech_Male> and this <Speech_Male> triple combination is <Speech_Male> being tested on Mars <Speech_Male> patients in a <Speech_Male> randomized controlled <Speech_Male> trial in <Speech_Male> Saudi Arabia. <Speech_Male> Ram <Speech_Male> Desert showed <Speech_Male> no effect on <Speech_Male> a bola <Speech_Male> when tested last <Speech_Male> year but in test <Speech_Male> tube. An animal <Speech_Male> studies conducted at the <Speech_Male> University of North Carolina. <Speech_Male> In Chapel Hill. In two <Speech_Male> thousand Seventeen <Speech_Male> Ram desert <Speech_Male> inhibited. The Krona <Speech_Male> viruses that cause <Speech_Male> SARS and <Speech_Male> merge quoting <Speech_Male> Science magazine <Speech_Male> the first Kovic <Speech_Male> Nineteen patient <Speech_Male> diagnosed in the United <Speech_Male> States. A young <Speech_Male> man in Washington <Speech_Male> state was <Speech_Male> given REMM Dez aveer <Speech_Male> when his <Speech_Male> condition worsened. <Speech_Male> He improved <Speech_Male> the next day. <Speech_Male> According <Speech_Male> to a case report in <Speech_Male> the New England <Speech_Male> Journal of Medicine <Speech_Male> a California patient <Speech_Male> who received <Speech_Male> Rim Desert and <Speech_Male> who doctors thought might <Speech_Male> not survive recovered <Speech_Male> as well. <Speech_Male> Such evidence <Speech_Male> from individual cases <Speech_Male> doesn't prove a <Speech_Male> drug as safe and effective <Speech_Male> still <Speech_Male> from the drugs and the <Speech_Male> Solidarity Trail <Speech_Male> Rim desert <Speech_Male> has the best potential <Speech_Male> to be used in <Speech_Male> clinics. Says <Speech_Male> Jang Shibo <Speech_Male> of Fudan <Speech_Male> University Shanghai <Speech_Male> China who <Speech_Male> has long worked ON <Speech_Male> KRONA VIRUS THERAPEUTICS. <Speech_Male> Jiang <Speech_Male> <Advertisement> particularly like <Speech_Male> that high doses <Speech_Male> of the drug can <Speech_Male> likely begin without <Speech_Male> causing toxicities <Speech_Male> and quote <Speech_Male> the. Who <Speech_Male> did not originally <Speech_Male> intend to include <Speech_Male> chloroquine <Speech_Male> and hydrochloric <Speech_Male> line in the <Speech_Male> solidarity trial <Speech_Male> but ultimately <Speech_Male> added it <Speech_Male> since it has received <Speech_Male> widespread attention <Speech_Male> though researchers <Speech_Male> in both China and <Speech_Male> France reported using chloroquine <Speech_Male> and hydrochloric <Speech_Male> line <Speech_Male> to treat Kobe <Speech_Male> nineteen patients <Speech_Male> the society <Speech_Male> of critical care. Medicine <Speech_Male> notes quote <Speech_Male> there is insufficient <Speech_Male> evidence to issue <Speech_Male> a recommendation on <Speech_Male> <Advertisement> the use of chloroquine <Speech_Male> or hydrochloric. <Speech_Male> Line in <Speech_Male> critically ill <Speech_Male> adults with covert <Speech_Male> nineteen and quote <Speech_Male> <Speech_Male> the dosage required <Speech_Male> of <Speech_Male> chloroquine and <Speech_Male> hydroxyl. Chloroquine <Speech_Male> is <Speech_Male> usually so high that it <Speech_Male> can cause serious. <Speech_Male> Toxicities <Speech_Male> Suzanne <Speech_Male> Herald an expert <Speech_Male> on pulmonary <Speech_Male> infections. At the University <Speech_Male> of Glen <Speech_Male> Germany <Speech_Male> said of chloroquine <Speech_Male> <Advertisement> quote. Researchers <Speech_Male> have tried this drug <Speech_Male> on virus <Speech_Male> virus and it never <Speech_Male> works out in humans. <Speech_Male> The dose needed <Speech_Male> is just too <Speech_Male> high end quote <Speech_Male> as for <Speech_Male>
"lapenne aveer" Discussed on The Jason Stapleton Program
"And We're just GONNA you know we're put you on on the Gurney and and knock you out here and go do the best we can so there you go. Is that the doctor you want or do you want the doctor that walks in and says listen? I know you scared right now. I know that you've heard all the horror stories about the downside. Risks here of of you go into the surgery I want you to. I want to tell you you. Are you got nothing to worry about? You are in the best hospital. I am the very best doctor. I don't know what kind of luck you had to find yourself in this hospital with me as your doctor but you hit pay dirt my friend. You fell backwards into gold dust. Because I'm going to take care of you and you are gonNA come out of here looking and feeling better than you ever have in your entire life ready. Let's go. Which guy do you want. We all want the guy who's GonNa who's GonNa lie to US and so what the Martian where people needed was for Mnuchin to come out and say it's fine with giving nominally effective. We're going down for a few months. Yes we short term downside but the reality is this economy is going to bounce back. We're strong doesn't matter whether it's the truth. We want somebody to lie to US and today or yesterday he just decided. I think I'll tell the truth. The one time we get our politicians telling us the truth is the time when we need them. The light it was the most reminds me of that The commercials like at and T. Or something where? It's only okay isn't okay. Y'All got reinstated. Dr Who comes in? He's like welcome back. He's like you nervous and the kids like yeah. He's like yeah me too. I hope it works out. No it's great. I just I for the life of me. I can't I don't I cannot understand why he would why he would do that but he. I mean he did it. And that's where we're at now but listen if you have been at and again I don't want to. I don't want to give you the impression that it's all. It's all too late that it's all over now. It's too late to make better choices. Better decisions that. It is always the right time to do the right thing. The it is a Matt and AIMEE. It probably heard this more than the than they want to. But it's something that I constantly reiterate is doing. The right thing is always the right thing to do. It's one of those cheesy. Slogans that CAN ARTICULATE. Exactly what you want to infer what we want people to infer. Which is I? Don't care what it costs. I don't care what I don't care what it does to the business or the reputation doing the right thing is always the right thing to do. So should we do the right thing here or should we do this other thing? You should always do the right thing. That's always that's my mantra. But if you have done if you had done what I asked you to do earlier and you had said you know what things are going. Good right now. Stock Market's on a high of full UNIM- full full employment. Basically I'm getting a raise. I need to start working on something for myself. I need to do something to protect myself so I need to increase my knowledge and skills that I have a better handle on my life and more control over my money. My time and And and my future. If you've done that then you are in a far better position than anybody. Who didn't because now they're going to be a whole lot of people because we are going to have. I on employment we. We are going to see that. Tikka there are gonNA be layoffs People are not going to be buying and they will be we eating into what little savings that they have and borrowing money in order to try and stay afloat which means dead accumulation for the future which means Suppressed buying in the future. These things are coming and but they're also going to be if we at twenty percent unemployment. This is what I want you to think about. If twenty percent of the population is out of work we are at depression. Era Unemployment eighty percent of Americans will still be employed eighty percent of the world. Population will still have jobs. They will still have money to spend. They will still be out there. The smart ones will still be investing in themselves. They will still be trying to grow their companies. They will be trying to find ways to capitalize on the benefit of reduced competition. Because here's what happens in these kinds of situations. Is that before there was all kinds of competition? Why because money was good enough appointment was high and everybody was spending spending spending and so lots of new competition POPs up a lot of really inefficient competition pops up as well and then when tragedy strikes when the market tanks and craters. You see all that competition all those week wannabes who are filling up the feed who are who are clogging up your market. Start to disappear. Because THEY CAN'T HANG. They weren't positioned well for this to happen. And so they don't know how to capitalize on it and who are going to be left to the people running the best businesses with the best products and the best service and for those people. There is going to be a mountain of opportunity presenting itself and it is never too late to start. When I started my trading business. I started in two thousand and nine. Didn't really take off until two thousand and ten which was still at the very bottom of the economic recovery. People were two thousand nine. People were still freaked out that it was all going to end and ended up growing that company exponentially over the next several years wall. We were still in a recession. There is no bad time to start changing your life. There is no bad time to start improving your knowledge and skills and taking charge of your own life and your future. It's no bad time for that would have been better six months ago. Many of you heeded my warning and you got busy but the fact is is that is never a bad time to do the right thing and so I'm going to reiterate to you guys again and again I'm not gonna I'm not GonNa beat you over the head and talked about how ride I was. And you know So that you guys can. Everybody feels bad about the fact that other in a bad financial situation right now. I don't think that benefits anybody. What I am going to do is continue to remind you that it is not too late and you need to be doing something you can start at trade with. Jason can come attend this Free Seminar with me and we'll spend a few hours together learning a new skill. That will last you. A lifetime came Matt. You had some good news. We'll switch over some good news and I'M GONNA run back to some of this economic news. That isn't so great. But you had some good news on the on the corona virus front just in terms of Inoculations and stuff. Yeah on I actually a lot of this I I got from. I've seen it all over the place but a guy listener. The show named Phil Sinatra Gone cumulated all into one post yesterday which was super helpful. I'm just GonNa go down and just read off the list So the the first one is that China is close down at last Corona Virus Hospital. There's not a new not enough new cases to support them because I don't know how many people knew China went absolutely ham and just built like multiple new hospitals just to deal with this issue I would still be a little skeptical on of China's numbers. Just because they are known to. To to falsify their numbers and they've got good incentive to but the fact that they're closing down the hospital that's probably a pretty good indication. I'm doctors in India have been successful in treating grown virus with a combination of drugs. One is Look Lapenne Aveer. Another ones are Raton of ear and other ones Oseltamivir. Along with chlorof- inamine. I'm so they're coming up with a multiple different drugs. That actually are showing some promise. And there's another one that people have been talking about. It's called hydroxy chloroquine Also known as Black Hill which is an anti-malaria drug on but a lot of people actually take it for arthritis lupus and it's an immune it. This is a little counter intuitive. It's an immune system suppressant but the reason why that helps is because the way the virus works is it starts by suppressing your immune system until viral load has built up in your respiratory system. Then suddenly your body realizes that that been infected and it freaks out and overreact and then basically your body's immune response destroys your organs is kind of what the way that the worst case scenario. Go so what you want. Is You want to build your immune system till you get it. But then you want to suppress your immune system after that. You weren't you saying to that. Create them has been has some very anti Anti viral properties to it as well. That's there's that's been Ben Asserted by some doctors in Southeast Asia. And I would I would make it that neither of us or medical professionals and we just take for me personally. I'm Kinda like I'm going to try anything. I'll do whatever it takes to try to build my immune system so I'm I'm mega dosing. Vitamin C dosing Vitamin D. I'm taking turmeric. I'm taking oil of Oregano. I'm also along the lines of of counterintuitive. There's also indications that elderberry Syrup and ECHINACEA are actually. I'm not recommended if you have symptoms because again they would see the. It's called a cytokine storm. Cytokine tonight pronounce it Cytokine storm where your body freaks out and sends a bunch of antibodies? And I'm so you don't want to have these on these substances that that create that response. Gotcha so when I don't Wanna I don't WanNA see again. I'm always cautious because I read something the other day from from French researchers. Who said if you get sick? Don't take Ibuprofen? Take Tylenol Acetaminophen. Because apparently the ibuprofen is causing some cases to get really severe. And I'm like I question whether even put that information out there because I'm like I don't know whether it's true or not but it seems like it couldn't possibly hurt to not as as of this morning the. Who is a fish has formally stated that that's the case? Okay okay so that is a major concern. That don't take advil or Ibuprofen or anything. If you get if you get sick for your fever take tylenol and stay away from that stuff because apparently it causes really severe reactions. Yep Okay so going back down the Oh so the other hydroxy chloroquine and zinc together was the was the one recommendation this. There's a couple of doctors that have been on this for a while now because basically what it does zinc stops the replication process of the virus. But you have to get the zinc inside the cells to get to the virus so on you have to have basically like a key that opens the door and that's what the Diet drugs chloroquine on does and it's so it's relatively inexpensive. You can't just take zinc supplement and have it work. It's got actually be combined with his other stuff. It's good to take zinc. That's another important one to take on but then especially like if you're starting to experience symptoms The best thing to do would be to take Like an oral lozenge. That you dissolve in your mouth on because if you just take the zinc and it goes down into your stomach. It's not GonNa have much of an effect in your respiratory area. Gotcha so like the tablets that you get from like Xichang or whatever and you put them on your okay. Yeah cool exactly all right So I've got a couple of those left and I'm just waiting until I'm until I get symptoms then I'll hammer it with a couple of back to back. How are we looking at numbers right now? In terms of the number of people that are showing infection and showing signs of infection. Is it continuing to double every couple of days on this last time we talked on right now? The official numbers is something. Like seventy five hundred. I think as of this morning infected in the US. But it's still on wildly understated because there's been such a limitation testing and it's kind of one of this the way this works is like if you don't test at the beginning then you get behind the eight ball and then you kind of can't catch up. And the countries that have been really aggressive about tamp it down were ones who tested really aggressively early on so South Korea and the US both experienced their first patient about the same time the US is somewhere in the vicinity of twenty or thirty thousand tests. So far and I think South Korea north of three hundred thousand so on. That's a big important thing. And that's that's another one of my my Positives one of my optimistic points. Here is that There's a loud in Utah that has come up with a way to To test they've created. I think they can do. Fifty Thousand Tests Day create fifty thousand tests today For Ten dollars so but they're just waiting for FDA regulation to allow it So this has been kind of the narrative here is that there's all the federal healthcare bureaucracy has bogged down the rapid response..
"lapenne aveer" Discussed on The Peter Attia Drive
"I guess probably seven or eight other drugs including chloroquine. So do we want to say something about chloroquine which is currently being used off label to treat a number of patients. What can we tell folks about that? I think some of what we're we're seeing in the news. Reports and case reports is really kind of inertia rather than data chloroquine had been used in. It was SARS or Murs. I'm blanking on which one it was used in the study there. They didn't show clinical end points but what they did show is that there was a rapid decrease in the viral load at relatively low concentrations and so it stands to there is a kind of high sequence. Kamala g between both SARS CORONA viruses SARS. Moore's and now Cova nineteen and so it stands to reason that mechanistically it might be susceptible to some of the same weaknesses that Clark win helps exploit which effectively again. I'm not my understanding of pharmacology. Here is incomplete but it changes LEISA SOMO PH and makes it a little bit easier for the immune system to destroy the virus and makes the environment a little bit less hospitable to it. So yeah so I mean it. Decreases the viral load pretty quickly in the previous krona viruses? So the doctors who Han rightly so said. Listen we've got people who are on that store? We need to at least try something. So they threw on the chloroquine the viral proteases which is what because the corona virus is an rn. A virus uses a protease that is similar to the protests that helps HIV replicate and so it also stood to reason that some of the HIV medications namely Retana Vir Lapenne. Aveer was tried. A few of them are currently in clinical trials and the return of lapenne. Aveer one of them really just prevents the from being degraded. So you're only getting the action of one of those but they've been using both chloroquine and the HIV antiviral together anecdotally. They've seen some result. They haven't seen any obvious harm from it. They seem to be using it. Mostly in the severe cases I do know I've seen the protocols now from a few hospitals both in China in the Lombardy region of Italy as well as in and it's now being used kind of as the standard protocol for anybody that's considered to have severe version of the virus. Yeah so electra. Being the trade name for that along with chloroquine is probably I think as of today what would be kind of first line adjunct beyond the obvious supportive care so there's another drug out there that seems very promising rim dissa veer which is a drug that's produced by Gilead. It was obviously someone's listening to this and saying Oh my God that's amazing already. Came up with a drug. No this is a drug that had been in the pipeline for a long period of time to treat Ebola but it's being re purposed and being used via compassionate exemption. I've seen reports. That Gilead is being incredibly generous with it and that it's very easy for physicians to access this through direct contact with Gilead but again this is not at all being used prophylactically. This is being used in treatment again. I I haven't seen anything in two days on it. Are you aware of any updates? In the last forty eight hours that are moving us either to a more bullish or more bearish view of that. Yeah I think everything is pointing to remedy severe having some clinical impact is it. Iv Only I think it might be. Maybe that's the reason that it hasn't been rolled out more widely at we'll have to fact. Check that for you guys after we record but I know at least the producers of Kalita are ramping up production pretty quickly so there hopefully won't be any type of run on the drug or shortage and certainly I don't think we are generally recommending that our patients who have mild to moderate illness necessarily take this drug right. So it's probably the case that if you know you're going to have a self limited illness you don't want to do much of anything because even the best drug is. GonNa maybe shorten the duration by a couple of days. The question is is it going to prevent you from converting to severe more severe form of the illness? And we don't know the answer to that so it's really hard to make a blanket recommendation that everybody who is either suspected of or test positive for the virus should begin taking so. We're still struggling with what we're telling our patients in particular. We've had at least a few calls this week from our patients and it's not always obvious that they should start the medication because a testing is not widely available so this is a cold than certainly. The only thing that could do is harm and it is then. We're kind of flying blind so this is nothing that med school really prepares you for in terms of answering the question on which medication to treat which that said. I think what would also be useful for US? To talk about is how our thinking has changed in terms of from a public health perspective from containment to to right. So what are we telling our patients to do? What are we doing ourselves? And what are we recommending? The public do in light of the current Government Response Right. So what constitutes a reasonable response if we locked everybody in their room for two weeks or three weeks? Would this virus disappear? I mean in theory? It would unless it has like a reservoir where it's not cleared by the immune system but that's going to cause obviously grievous economic harm as it already has so. I think my suspicion is that last week I thought you know. Maybe there's some slight possibility of containment that we're able to track down. The cases do a strict contact. Follow up for anybody who is suspected of having the disease watching that unfold and not seeing any guidance from from the CDC or the authorities. I think it's now what the UK is doing is essentially. They're just saying listen. We're aiming for her immunity so they say you're going to get this disease we're going to expect forty to seventy percent of the population get it over x period of time and hopefully with that. It's not going to be a continuous exponential increase. At some point there's a difference between an exponential curve epidemiologic one. So do you want to kind of dive into your thoughts around that public health management? Piece Peter Yeah I mean. I think it's important to explain why these things can't grow exponentially forever. And that's why simply doing line extrapolations with simple calculus equations is not the answer here because that's how biology works. Every time you do a calculation you make an assumption and if you go from the early replica to cycle of a virus. The assumption you're making is that each infected person is able to come in contact with a given number of uninfected individuals so when we talk about the are not or replicated number being again Peter. Hotels was quoting some of the most conservative numbers. I've heard which is about two and a half to three and a half others we've spoken with have all been more in the three to four and one person even suggested five as a replica of number so again but suffice it to say we don't know what it is but it's. I think at least in the threes meeting. Every person who gets the virus is able to infect on average three other people will at some point that math starts to become a bit difficult to maintain because there are enough people that are infected. And you're presumably knock going to reinfect somebody or infect somebody who's already infected which of course becomes a logical. So that's what really starts to slow these curves down a little bit. And that's kind of what we talk about when we go from exponential growth to exponential slowing and of course it's the latter that we wanna get to now. We're not there yet. Obviously and in fact the most recent data that I trust are two days old so our favorite databases for tracking this are starting to break and therefore I'm losing faith in the twice a day updates that we're generating off the primary sources so Patou days ago. I was seeing data that I found that I thought were actually quite reasonable. They were very disconcerting. So on the one hand you can look at China and you can see that on the back of Wuhan it had an exponential growth period through about February eleventh February twelfth before hitting an inflection. Point which is when it turns from being an upward shaping curve that could hold water to a downward shaping curve that would have water roloff. It's think of an upside down. Gulliver's is a right side. Opole if you look at the cases outside of China up until March eleventh there is absolutely no sign of abatement and it is a perfectly increasing exponential curve. Furthermore when you break it down by country you see that of all the countries that are not China for which we have reasonable figures. Only South Korea seems to have passed its inflection point the other countries with major foe sigh of infection which are Italy and Iran at. This point are still on the upward trend and then of course if you exclude. South Korea Italy Iran and China. You then get into this. Next Tranche of France Germany Spain Japan in the United States Switzerland etc. And all of us appear to be still wildly on that uptick where we are still in the exponential phase. Now you throughout some numbers earlier. I think Mark Lips. It has been the most vocal on those types of assumptions that go into the type of analysis they were hearing coming out of the UK. Which is that. Hey look is this is simply the new norm and in eighteen months or in two years. We should just expect that. Fifty percent of our population has been exposed to this virus and there's a mortality of somewhere between half and one percent. I haven't seen the full discussion but I saw the summary discussion that came out of UCSF two days ago and they were projecting somewhere between. I WANNA say one three two one five million lives lost. American lives lost within about eighteen months. And that's they say the story right like a million lives. Lost is a statistic a single life. Lost is a tragedy. Well it's important to put those statistics in perspective last year. Two Point Eight. Roughly million Americans died of every single possible. 'cause imaginable heart disease stroke cancer. Copd suicide accidents. You name it every single cause of death. We'RE TALKING TWO POINT. Eight million that gives you a sense of what a million lives lost in a year to an infection would look like it is truly something we have not seen in one hundred years in the United States and so that is a frightening statistic and again I don't know that that's a fait accompli. I don't know that that is something that is necessarily going to happen. Well it's important to know. I think that the are not or the replica of rate is not an intrinsic property of the virus. It actually is some of the viruses infective kind of capability and its ability to access new hosts so the are not when if human beings were not the social species we were and we were all kind of holed up in our rooms. The are not would be much lower and so from a public health perspective. What should we be doing to make an effectively lower or not? And how low do we need to make it in order to make this manageable because obviously at some point the government's going to have to decide what is the acceptable rate of infection. Here such that. We don't have a prolonged economic crisis and try to balance it with the other factors of running a functioning society. What do you think Peter? What is the best case? Scenario of government action or intervention or public health action and. What would you like that to accomplish over the next? Let's say three months. That would make you more or less confident about how we manage this as society. I mean truthfully I don't feel like I'm qualified enough to speak of that in the United States. Because it's so complicated. I mean I can tell you that if I were the czar and I had a magic wand and I could do anything I wanted in this country what I would do. And of course certain countries that have governments that function in a more streamlined. Manner might have that. But let's start at the very top and work backwards go from objective strategy tactics so the objective would be to reduce the amount of lives lost and the amount of suffering and the amount of economic damage. Okay that's the objective. What's the strategy while the strategy is very clear and you actually began to allude to a second ago a few days ago. I posted a video on instagram where I explained the are not or spread versus legality and a graph and I showed people in that video a drawing I had made where I placed the SARS covy to virus on this graph in relation to chicken pox H One n one Spanish flu ebola smallpox polio and measles and I said basically. We don't yet know where this disease is going to shake out but it's sitting at an awful junction right now. Awful in that. It has a relatively high rate of spread in a relatively highly valley. And that's for a deadly combination while that also points to the answer. The strategy is to reduce both of these. If you reduce the rate of spread from say three point five to one point one one point two all of a sudden every person that gets infected on average only infects one other person. That's a huge change from where we are now. Furthermore if the mortality of this disease goes from one to two percent which I think is still a very conservative estimate. And I've seen nothing to suggest that were significantly below that but if you could reduce it from say one point five percent two point five percent that would have a profound effect so again if I'm now thinking about this. Through the standpoint of this framework the objective is to obviously reduce. This strategy is to do everything from a scientific and policy perspective to reduce are not and to reduce the Saudi. So that begs the question. How would you do that? Well you've already talked about how you would reduce are not you could theoretically reduce are not two zero if we were all automatons if you decided that every person needed to live in an isolated bubble and they couldn't come in contact with anybody else within about two weeks are not would fall to zero but for obvious reasons. That's not practical. So then the question is what would a practical policy solution?.
"lapenne aveer" Discussed on Real Life Pharmacology - Pharmacology Education for Health Care Professionals
"Oscar basin pain <hes> saint john's war to revamp in all of these drugs have the potential to lower concentrations of the roxie progesterone so where what does that result in or how can that be problematic if we have lower concentrations of that drug which are contraceptive active method. We're going to run the risk of that contraceptive method failing in increase the risk of pregnancy which is likely what's your patient absolutely does not want if they are getting this injection on a routine basis so it can be pretty tricky to catch this because he don't if if they're seeing a specialist let's say and they put the patient on carbamazepine for example <hes> and they may totally forget that they're actually receiving drug in that every three month injection so definitely very very important to educate <hes> your patient to let other <hes> providers know if they're seeing specialist. If they're on a lot of medications let let them know that they're receiving <hes> this injection and that's what they're using <hes> for birth control so critical critical <hes> patient education point there. I can't emphasize that enough <hes> because you are putting your patient at risk if we start something say they get their injection a month ago and now they're seeing specialist for something you don't. It's just not on their mind that they're getting this injection <hes> once every every three months at at least for most patients it's not going to be on their mind so very very important to remember <hes> some of those drugs and the risk that they can <hes> causes ause as far as inducing metabolism and reducing concentrations leading to an increased risk for pregnancy. There are some hiv drugs <hes> if fabrications return of your lapenne aveer <hes> there's others as well <hes> so remember if you've got a patient who is on an h._i._v. Regimen that i would definitely be somebody i would be looking up and basically running that drug interaction screen <hes> ensuring that <hes> d._m._p. Can be used just as a contraceptive method and we're not gonna have <hes> those of enzymes and lower concentrations putting winning our patient at risk for pregnancy other drug interactions. <hes> probably the the big one. I wanted to point point out that that you will see warnings on precautions on <hes> patients who may be at risk <hes> for qualification disorders so if if you've got a patient on an anticoagulant which isn't terribly common obviously in our younger patient population. That's probably taking this <hes> four birth control all but if you happen to have a patient <hes> that is taking an anti coagulant or at risk for some reason <hes> there is potential <hes> former norman drugs e progesterone to increase that thromboembolic risk so important to remember that obviously that can be a really serious thing if it induces uses that risk of of clot raises that risk a little bit <hes> that can obviously lead to a serious <hes> serious complication there without. I think i'm going to wrap up.