29 Burst results for "Kasim"

"kasim" Discussed on WABE 90.1 FM

WABE 90.1 FM

02:09 min | 11 months ago

"kasim" Discussed on WABE 90.1 FM

"Used in the infamous Steele dossier Igor danchenko was one of the primary sources for reports that ex British intelligence officer Christopher Steele compiled in 2016 about then presidential candidate Donald Trump and his alleged campaign ties to Russia That dossier was part of the FBI's basis for conducting surveillance on a former Trump campaign adviser Donchenko is the third person to face charges in connection with special counsel John Durham's investigation into the origins of the Trump Russia probe You're listening to NPR news From Germany Registers in Atlanta Good afternoon I'm Jim burris Our time now is four O four Atlanta city council member Andre Dickens has taken the second spot in the November 30th runoff in the race for Atlanta mayor Dickens narrowly pulled ahead of former Atlanta mayor kasim Reed who conceded this morning Reed sent his congratulations to Dickens and opponent outgoing city council president Felicia Moore who won about 40% of the vote in Tuesday's election Dickens got about 23% of the vote barely 1% over read Opening arguments are set to begin Friday in the murder trial of three men accused of killing ahmaud Arbery The 25 year old black man was jogging in Brunswick Georgia when he was shot in early 2020 Lisa Hagen has more After more than two weeks the court is closing in on finalizing a jury and alternates out of the original thousand people summoned Lawyers in the case are expected to begin making their last strikes of potential jurors on Wednesday So opening arguments could begin by the end of the week Defense attorneys are expected to argue Travis mcmichael shot or mod Arbery in self defense during an attempted citizen's arrest George's citizens arrest law was repealed earlier this year At the time governor Brian Kemp said Arbery was quote the victim of vigilante style violence that has no place in Georgia However during the trial jurors will be asked to weigh evidence in the case according to the law as it existed in 2020 Lisa Hagen.

Igor danchenko Christopher Steele Donchenko John Durham NPR news Jim burris Atlanta Atlanta city council Andre Dickens mayor Dickens kasim Reed Russia Felicia Moore Dickens Donald Trump Lisa Hagen Trump
"kasim" Discussed on Perpetual Traffic by DigitalMarketer

Perpetual Traffic by DigitalMarketer

04:56 min | 1 year ago

"kasim" Discussed on Perpetual Traffic by DigitalMarketer

"So that you get the right sort of results. So you're using ai. Instead of just you know spending four hundred thousand dollars on a display ad inside oprah magazine where you don't really know how you track point is is that and we actually have customer. Who did that by the way and then came to us but the point is is that you have to have all that in place and if it's not your cup of tea i don't drink tea really all that much. Then you need to hire somebody to get it and get smart people on board or at the very least do use google analytics a lot of basic stuff you can do for us. It's third party sources so you can get first party. Data which is the future semi-rough. That's such a qualifier which you said. That's the sound bite for listener. If you heard somebody from an agency say this is the way we have a proven and proprietary solution. That's what you wanna hear. We have a proven we've done it before proprietary this is us So ralph you like. We use a third party solution. I bet you have your favorites and then you can explain why you use those third party solutions agencies. It can't do that. Gosh you just need to be careful with them or they need to have their own archives. Were building our own. So it's like we don't really like everybody else's the point is like have to have another solution. I mean first party data is the key right now. If you're you know a director of marketing and you don't hear first party data and your sales pitch and all you're seeing is cool creatives and all these other whizbang things that maybe talked to the experience or the the ability to be able to get you results. If they're not talking first party data back to you that you really need to look. Keep looking on your side. It's at the base level using google analytics right on the like everyone a year. Customers obviously tied back into the google platform. Most of them aren't using google analytics. I would say and then that's one of the first things that you probably install within the first couple of weeks of working with a new customer. He you know what's funny about. It is so. I like. I called the trifecta. We try and triangulate later. Data we track data in google ads in google analytics. And then they're so they're ecommerce in shop or if they're legion in their serum and those three data sets should match ish ish. We'll ed's allows you to import not perfectly matched. what well what's funny about it is. They're both google property. So you'd assume you want to get him but you know they have different attribution models in different ways of tracking so you're adding olympics will never be one hundred percent but the fact that..

oprah magazine google ralph ed olympics
"kasim" Discussed on Perpetual Traffic by DigitalMarketer

Perpetual Traffic by DigitalMarketer

05:38 min | 1 year ago

"kasim" Discussed on Perpetual Traffic by DigitalMarketer

"So i think that's that is so we're kinda on both sides of the equation here to a certain degree. But i think there's pros and cons on both but you as a business owner you know cmo vp of marketing. When you're making this decision. I just have to weigh both sides of the equation to a certain degree and i. I think there's value to both because we've seen it on both sides so but the point is you want to have that experience. You wanna be able to see all right. Do they have case studies. Do they have testimonials like not necessarily in my specific specific niche. Maybe if you do. Google you know montessori advertising agency or whatever it happens to be maybe you can find somebody in your specific niche and may be start there and then branch out after that. I don't discourage that point is they have to have that experience and it's not necessarily always the industry of the exact niche experience because of the you know the cross ponds ation of ideas angle. So let's get onto point number three here. And i think this is an important one for both of us is tracking and reporting on saying. It's number three because assuming it's going to be your number three but putting words in your mouth that is kind of an important one to have dialed in or would you rate that differently so this it gets really tactical and if you're not used to the digital marketing world you might hear that and go. Gosh y'all we're talking at a really high level a moment ago we we were talking about goals and direction in whatever and then all the sudden we just got really granular. And the reason for that is because mike's princeton. And i'd be interested ralph if you've had the experience when i look at failed campaigns which we do all day primary collection..

cmo Google princeton mike ralph
"kasim" Discussed on Perpetual Traffic by DigitalMarketer

Perpetual Traffic by DigitalMarketer

03:50 min | 1 year ago

"kasim" Discussed on Perpetual Traffic by DigitalMarketer

"Is your host ralph burns and this is episode three hundred and twenty three. And i'm really excited because it's just mean qassams so low this week no gas. Nobody distract us. Nobody to argue is maybe. We'll just have to argue amongst ourselves instead. Pick a fight amongst ourselves because today's topic is something that's near and dear to both of our hearts here is. We're gonna be talking about how to pick the right marketing agency now before you say. Oh my god ralph. Let's so serving. Yeah you run to your eleven and costume run solutions eight. Will you know half of the listeners. If not more people that are actually looking to grow their business and usually do that by either doing it internally so you can certainly take a lot of the stuff here ply that to your internal team or if you've got an agency right now that's running traffic for your running your marketing or maybe you're looking for another one. I think there's going to be important points here and we will try not to be as self serving as humanly possible educational as we always are here on perpetual traffic. But you know we to reliance experience within our own agencies so having said that qasim Great to have you back. I know you on vacation last week. A well deserved vacation for us to be talking a google marketing facebook social media agency stuff today. Yeah i'm excited to be here and to the point you just made. I think that this topic is critically important for businesses on a growth path because my experiences everybody makes an. I'm no different by the way everybody makes the wrong first choice. You always universe agency always. That's just it's like it's like an entrepreneurial rite of passage and so if there's anybody out there that we can either say from making that decision or at least help. Soften the blow. Yeah i think that this is going to be where the conversation. Yeah and i'm gonna go out on a real limb here and piss off a lot of listeners but a lot of agencies really suck they really do go out on a limb there at all ralph. I feel like that's just. Yeah so all right..

ralph burns ralph qasim facebook google
"kasim" Discussed on The Smoking Tire

The Smoking Tire

06:27 min | 1 year ago

"kasim" Discussed on The Smoking Tire

"Disconnecting sway bar and only has five goats instead of six or seven right despite that zero problem with the trail. Yeah in fucking just right up. The trail picked the hard lines. You know very little work required by the driver. Yeah and it didn't have hill descent control which i don't use that much anyway but with the low range might as well be hill descent control. Yeah we we put in low first gear. And i mean i think i took my foot on a pretty steep slope and it was going to miles an hour miles an hour. Yeah we reached my personal limit or highest score of thirty degrees hill. A little to tilt. Yeah we had a problem or see-saw at one point. We had a rear wheel. That was at least three feet in the air you know and it can. It'll lean over pretty far and make some who come out a little bit. It'll it'll get up that hill. Yeah it. Was you know it performed so well that it would be tough for me to to justify to any non. Very hard core off. Roader that they need more. I mean i can't. I can't imagine what more i would personally need than to be able to get up a trail like that with ease. Yeah like we said. The only thing we noticed in the fire road to get there was that the regular shocks are a little bouncy like the suspension is tuned for the street. It feels like on. The ride was really good on the fire road. The ride was awful. Really i mean i was. I was shocked at how bad it was the second i hit fire road now. We didn't air down stock air pressures And it got a little better. When i switched from two wheel drive to four wheel drive because i think i was. You got a little less. Hop from the live axle But still the ride was atrocious. Owner just kind of pogo ing around your cabinet. In the comparison we had is because we had outback wilderness. There that road like dreams rides great by itself objectively them when we went from one to the other like. Oh this is what a softer strong software damp car can do. Yeah i mean that was built by a company that builds rally cars You know and so we thought that unibody body on frame but i'll sure suspension was definitely better put The we talked with johnny about taking the outback wilderness. Up off the trail that are trail as you'll see in our bronco video it that shale evolves and changes and yesterday it was rocky and really rutted and there was no way. i mean. We could've tried but we would have broken it for one percent. We would have broken it. Yeah something a phone call. I wouldn't have had to made. Yeah johnny the. I think the last time we did that trail it was The more more dirt covering rocks which also made those little kasim smoother because they were filled in and this time much more jagged which actually aids interaction a lot. So i think those tires the all seasons they perform well there. Yeah but like the land cruiser might not have gotten stuck if we went up when it was sandy yeah But the drops. I mean we would have scraped a lot of stuff. It didn't have the ground clearance. Yeah or the or the torque really because of the cvt yeah Having said that it actually worked out well because the difference between it and the bronco on the fire road was real like oh we should film this on the fire road because you can actually drive at like a rally car a little bit you can flick it and oversteer it into a into a loose surface corner which you'll see in the video And with that extra ground clearance and suspension travel. You know you can hit stuff. Pretty hard on a fire road you hit jumps and i jumped it a little bit You know and you can Go straight over. Some routes that in a in a traditional rally car you would avoid because it would be not tall enough yeah That's a nice car. It is really nice. A really nice car under forty thousand dollars to start the thirty s like thirty eight grand start which is eighteen hundred more than the regular outback mill. You get the clearance. You get the you can get the Skip plates option It's basically really for the clearance and then like the bronze tow hooks and those kinds of things. Yeah the fabric sides nice. Yes got the water It's not water resistant. but it's like it's easy e-especially. Easy to clean the called star. Tech's something like that. Yeah they got they always gonna come up with these new named rick. Well they starts. Because i think the subaru thing that makes their media system is link which is slow and that needs an update dustless darling. It's it's not good it's fine put man. Does it react slow. Like a couple seconds hit the button then hit the button then hit the button and it and it and it's not actually as simple as it looks get getting through the menu like it took take me a while to figure out where to find stuff Despite its like all their icons are so big that they blur together so it actually makes it less intuitive navigate. Yeah it and it just it. There's certain like there's the row of buttons on the bottom. That's like one is the home button. And then another one is for like car functions and like it's not immediately obvious which button you should press for certain stuff i mean. Obviously if if you use the car lot you'd figure it out but like going back and forth between like my phone car and the radio like was not as intuitive as i wanted I kept having to manually do it for some reason. Like if i had directions come up on carplay. I'd have to like click back to radio. That was kind of annoying I the more. I use the system. The less i liked it honestly but everything else about the car. Lot of car for the money in rear seat trunk rooms great. It's basically as tall as my machi. Subaru considers or other roof to roof. Okay yeah it's pretty much the same fight as the machi. Wow it did have a lot of headroom. Yeah it's got a lot of room. It was nice. I mean in general and we still got it for another few days So if you've got follow up questions that we didn't answer. We drove a little bit on tarmac. We drove it a little bit of fire road and we went over a couple obstacles in the obstinate in the offered practice area. We did So you get you get a pretty.

johnny kasim rick Tech
"kasim" Discussed on Perpetual Traffic by DigitalMarketer

Perpetual Traffic by DigitalMarketer

03:26 min | 1 year ago

"kasim" Discussed on Perpetual Traffic by DigitalMarketer

"You still need some selling in the news feed and what we refer to as an explainer video. This is a different type of video than the teaching pitch so we probably wouldn't use the teaching pitch in that particular case we will use more explainer videos. Quick short stuff but still like today have a sales funnel they kind of do to increase their average order value. There are hybrid. they sell that upfront. And then on the back end. There is two different up sells for two different products which are sort of add on to the original shelf so in that case that's an ideal customer for us because we know that we can increase average order value like doing consulting on the back end can also enhance. The sales page can also do all kinds of other video assets on the front end. That would be an ideal ecommerce customer for us to work with. Would that work on google shopping. I don't know. Can you get their attention. Could you get somebody to click to understand all that kinda like yours. Waddling babies in customer might be a little harder to do so. There is a case for and against potentially a sales funnel or modified sales fall. When you just said something to that maybe this is a semantic argument. But like you mentioned the order bumps. After the fact i never thought of ordered bumps a sales funnels and if order bumps our sales funnels than i am now prosales phone because i think every commerce on the planet should have ordered bumps. I've got a buddy Pro scott cunningham. Over at socialite. And i forgot the percentage but it was like the majority of the profitability that they were creating for these case. Study clients if his all came from order bumps so they're selling the product just to liquidate the traffic costs and the order bump is where they're making their money. So there's my question for you is an order bump a sales funnel. Well they have in their case they have ordered bumps and they have a one time offer after they actually purchased so there is an order. Bump the misspoke. There's an order bump on the actual cart itself which is little check box. Get this and actually click over to their site right now to see what the order bump is and then after they purchased then there is a one time upsell which you know through. I think it's infusion soft. Or the i forget which they actually have. They then are allowed to upsell on that one time offer for you know super specific finish or a coupon to get this certain type of armament like that kind of stuff so it is definitely a sales funnel. It's a modified one. At least it's a small funnel but then there's you know there's upsell pathways after that. There's additional products that they can purchase typically through email. So is an order. Bump part of a funnel i would say yes. It is because there's some thought to increasing average order value. At least it's one. It's one tactic that you can use. Because at the end of the day like a sales funnel is to convince as well as to enhance average order value so you can are willing to pay more for customer especially in an increased competitive world especially in the platforms that we deal with primarily and obviously google as well so is that a sales funnel. I would say it's more than just sending them to a sales page or just to a product page rather and nothing because at least you have the opportunity to enhance that average order value. And like you said..

scott cunningham google
"kasim" Discussed on Perpetual Traffic by DigitalMarketer

Perpetual Traffic by DigitalMarketer

05:46 min | 1 year ago

"kasim" Discussed on Perpetual Traffic by DigitalMarketer

"Click especially because of a lot of the signal loss that's occurred with the irs update so for us. Sales funnels have become far more and far more of an integral overall approach. Combine that with front end assets that we know really really work in now. You've got a really killer combination even in spite of all the stuff that's going on right now so that would be my exception to know sales funnel for an e commerce business. The only well the second exception. I suppose would be. If you've got a product that nobody else has it's the only one. And i always say well if you have the cure for cancer you really don't need a whole lot to sell it. You just need to put yourself in front of the audience. That needs your stuff. Put it in front of the starving crowds so to speak. And then they'll buy it on their own and but the real trick with most advertising that you probably don't have a product or a market that's data distinct so you need to do a lot of advertising a lot of hook research lot of video up front a lot of convincing and the news feed before they even consider buying your stuff so if you've got a great offer that no one else has great for you. You just said something that resonated ralph and extra reminded me of a client that we feel that you're talking about if you've got the only thing you've got for cancer you can put your offer not in front of a starving audience. The issue with that is convincing the audience. That you're offer will satiate hunger. We had a client who invented a new type of baby swale. And when i took this on. I was a new dad and it was amazing. It was amazing though the swallow you could change the kid's diaper while keeping swallowed swallowed. There were all these like cool little pockets in the way that it went on and went off his way easier than the swallows. We were using unbelievable. It's really brilliant product. We ran e com. Smart shopping you know inbound in the beginning died on the vine in died on the vine because the value proposition was more complex than could be understood in the fraction of a second. You could see you know a little bit of the bureau videos or some of the images so to the point that you just made. That's a product really needed a funnel and that's not a tool. It's my tool belt. And so we just didn't go in that direction. But i bet you had. She built something that really explained what it was. How it did it. You know you're talking about your client with these three five minute videos. That's what you need it. You need three to five minutes to watch this thing in play and then you're like oh that's why it's twice as much because it's ten times as good. Yeah so i think. I think that's a point. We'll take the. I want to add to that is. There's a lot of products where the product is a piece of the funnel. We've got a client who sells in industrial tape. And one tape is ten bucks and the.

cancer irs ralph
"kasim" Discussed on Perpetual Traffic by DigitalMarketer

Perpetual Traffic by DigitalMarketer

03:15 min | 1 year ago

"kasim" Discussed on Perpetual Traffic by DigitalMarketer

"Consider that a funnel to a certain degree. Now there's email sequences that go along with it this. The sales call there's ultimately the sale at the end of the day. Like there's going to be a lot of convincing. That's going to go on after that landing page and thank you call pre frame page and then multiple touch points after that which isn't in our funnel but it goes off line at that point because they're buying something that's six figures potentially and then obviously then we is the agency that actually do a lot of their legion. Was they become a franchise so it's actually a good good way of doing things so they come in through facebook and then we ended up helping them grow through facebook and other platforms. Point is is like that is a sales funnel in my opinion because you are off line. Interaction is still something that is extremely important now. Can we put more pages in after that and make it sort of a classic click funnels sales funnel i suppose but all we really want to do is capture their attention on ads video. That's engaging talking about business opportunities etc get them to opt in and then it's really. It's our customers good. Follow up and they have supreme. Follow up in this case because it's obviously it's a sale that they want to be going after a that's a really good example of a service based business with a very high ticket item that can be sold through interruption marketing with a mini sales funnel. Man if it were just you know lead and then nothing else you know with really no follow up. Maybe we don't get their phone number or something like that. Just the will send them. A packet will put them into an email sequence after they initially show some kind of interest. In buying the franchise it would be far less effective. It'd be a non starter. When i think that's maybe where we're i'm spoiled because i'm a gu-guy i do you know we don't focus solely on search but that's where we start and so i get in front of somebody..

facebook
"kasim" Discussed on Perpetual Traffic by DigitalMarketer

Perpetual Traffic by DigitalMarketer

05:56 min | 1 year ago

"kasim" Discussed on Perpetual Traffic by DigitalMarketer

"Ubiquitous truth that marketers have made them out to be like it's weird because they almost feel like oh. You can't drive traffic without a funnel and in my opinion you need an excuse to have a funnel. It's not the default. In some of this might stem from the fact that you and i just served for customers of my anticipation i i know i. I definitely fish small pond than you do. But we've got professional services local services e commerce sas and those engagements when somebody's shopping for that type of service it takes time and it takes multiple touches and it takes multiple narratives and you want them to kind of self direct in a funnel doesn't allow for that a funnel a squeeze page per se. But i think funnels used squeeze pages as part of the kind of the scaffolding. I just don't think that our customers liked to be squeezed when they're shopping for especially hiring services. So the way that i'd i'd build the fork in the road is if you have something. That's an impulse. Something that can get a quick easy optin than a funnel starts to make sense but if you have something that's i don't use the term high ticket but longer sales cycle maybe higher end product or.

"kasim" Discussed on Perpetual Traffic by DigitalMarketer

Perpetual Traffic by DigitalMarketer

05:29 min | 1 year ago

"kasim" Discussed on Perpetual Traffic by DigitalMarketer

"Is the best digital conference digital marketing conference on the planet and yeah pretty excited to be attending this year so but today we're going to be talking about some other stuff which is sort of on the conversion side from the traffic side. We do talk about both sides of the equation. Not that they're really any sides but we might actually pick different sides on which we are in favor of here when it comes to the conversion and of digital advertising digital marketer in that is the idea of the sales funnel should you sales funnel or should you not sales funnel and that is the subject of today's conversation between myself and casa. I feel very passionately about one side. He on the other hand hills very passionately about the other side. So we'll see how this all plays out. And i think this sort of comes from an interesting moment in time in digital marketing especially within the last ten years or so. I don't remember the exact date. But i remember when i first heard about it. It was the launch of this thing called. Click.

"kasim" Discussed on ABA Inside Track

ABA Inside Track

05:11 min | 1 year ago

"kasim" Discussed on ABA Inside Track

"We should have less of that issue right because we should be being objective in our treatment programs in our iep's but you know that's not always the case. No because at the end of the day we are human organisms who are trying to complete these tasks and sometimes issues related to personal vendettas into feelings and opinions readings of research published. Or that's out there or practice we've used in the past that we've met hey. Those practices met with reinforcement. Why should change. What i'm doing after all this time. Reading the short amount of time can really run into some some problems so kasim lays out some of the major complaints in terms of you know that practitioners say have to do with well. This is why. I might not look at research too much or why. I think my opinion is a practitioner is more important than the research. That's out there and again it has to do with a lot of the themes we've already talked about the idea that well research uses specific analysis methods and while that might be great statistically to look at the efficacy of treatment. You're looking at you know treatment versus no treatment. And you're looking for this statistical significance which is not necessarily the same as i'm working with an individual who is not able to function and just because you have a statistical difference in a couple measures that you're using doesn't mean that it's going to lead to significant change in this real person's life that also speaks to the idea that the sample size variability within that sample size isn't going to necessarily capture. Everybody that practitioner might need might be working with in that research article that you're reading a lot of research might use. At least psychology. This is more problem in. Psychology uses rating scales. That don't have a one to one correspondence to actual life changes so again. We dodged that bullet a little bit in the sense that.

kasim
"kasim" Discussed on Perpetual Traffic by DigitalMarketer

Perpetual Traffic by DigitalMarketer

04:52 min | 1 year ago

"kasim" Discussed on Perpetual Traffic by DigitalMarketer

"The most important systems that you have i with google ads agency. There's probably eighty twenty. They're you know there's they're potatoes laws in there somewhere as like. This is the stuff that super super important and knows of the sap we're gonna use over and over and over again and they're the ones that need to be refined and updated constantly. In order to mitigate any sort of you know client issues or performance issues that come about so you just reminded me this. I didn't remember this until we just had conversations sort of reminded me that we used to have one person doing the client relation and the management. So we call those the client manager in the specialist now but we had one person doing the client management and specialised role and when we define the processes it was it was the systems. It was that definition that really drew kind of a stark comparison between the two tasks and we really quickly realized. not only. there's a lot of work here but it's different temperaments right brain sort of go out there. Shake hands kiss babies. And then there's the left brain. Nocturnal came dwelling over. Caffeinated doesn't wanna talk to humans type of whatever and having that process definition is what made it easy for us to to separate those two so we hire against the processes we train against the process. We fire against the process. It's like when your job and if not it helps diagnose issues. We had a thing where some of our campaigns running late specifically in e com. And we couldn't figure out exactly what was going on. So i just went back and looked the checklist and you could see where the delays began and it was with the client on boarding clients getting us the onboarding foreman time. And that does this domino effect and so we get to reorganize the way that we do on boarding so that boarding has to happen before we do anything and it solved. Art are delay. But we wouldn't have had that if it wasn't documented and we weren't tracking along the way you find the weak points you find where it is and it's usually it's a process weak point all right. Well we're giving it to them but there's no follow up like we might get it and the next day but we might get seven days from now. Well if you get the next day. That's great but like what's the what's the check point there order to make sure that it's done expediently. That's a process question..

two tasks two eighty google next day one person seven days twenty
"kasim" Discussed on Perpetual Traffic by DigitalMarketer

Perpetual Traffic by DigitalMarketer

05:08 min | 1 year ago

"kasim" Discussed on Perpetual Traffic by DigitalMarketer

"A lot of business. Where the hell do i start. I have all these things in my head. How do i teach other people to do them. I can't do one on ones for everyone. Well you know. The journey of a thousand steps begins with the first step and the point. Is that what you have to do. First is start documenting and whether it's video and for us when we first started it was everything that i would do for running a facebook ad campaign in this this case going back to two thousand thirteen fourteen fifteen i would just document it in either. Pdf word document now. Google drive google docs and just each individual time that i would do that task. Go back to that list and refine it and make it better so these were repeatable things like how to set up a campaign. I would just documented just writing it in as i actually did it step by step by step then. We started doing videos. Just like what. You're saying really smart by a pro tip obviously is doing a video. And having your writing teen transcribe it with screenshots. That kind of thing. What i really realized is that If i was doing it all i was limiting myself and limiting our ability to be able to scale and grow so as i started hire more people i would have them create us processes do videos on their own to do the writing on the road. So everyone who came in. What part of their overall goal as an employee of chair eleven was processes creation of processes creation of systems and refining. Them and making sure that they're updated so that the jobs that they're doing today by the next person that maybe you know in the case of a media buyer the heaven ads manager or maybe sort of an intern. That's working with them. That's doing the tasks that they used to do. So it's a never ending process of improvement but it's also something that you can just start doing today with. The first step is just simple documentation words video whether it's writing it down whether it's writing it down on a sheet and then transposing later on having your va it. The point is that's how you get it done and that's how you take that first step when you said some..

facebook First first step first two thousand thirteen fourteen today each individual time google docs steps Google one chair eleven
"kasim" Discussed on Perpetual Traffic by DigitalMarketer

Perpetual Traffic by DigitalMarketer

04:39 min | 1 year ago

"kasim" Discussed on Perpetual Traffic by DigitalMarketer

"The people are actually doing those jobs in the right way and that comes back to one of the big themes through that entire survey is checklist is processes is s. o. P.'s and. I know it's a big thing for you at solutions eight. Obviously it's a big thing here for us over at tirr eleven but it was a theme. That was loud and clear for all of us. And i think you know as business owners as agency owners. It's one of the things that people really struggle with. And i know you guys have been able to really dialed in your agency and we've certainly done it on our end as well know you talked a little bit prior to this about. I think the promise of an agency stems from two things your processes in your people outside of those two things in agency doesn't really have much to offer so if you have really good people in you have really good processes. I think you're gonna be able to do a really good job and for you know if you're listening and you're like well i'm not an agency. I'm a business owner. I think this is just as applicable to you if not maybe more. So because the average agency probably already has even if they're loosely defined they probably have processes in place. But if you're doing plan the diy game you're doing this yourself or if you plan on going and hiring a freelancer you know whoever to do it for you. You need to be able to inspect what you expect. You can't just say hey. Run my ads. Please go on facebook. you know. God bless you come back to me. When i have money you you have to. You have to be able to to make sure along the way. They're checking the boxes that need to be checked and so making sure that those systems and processes are in place i think is. I think it's important for everybody. Overstep their ralph. Would you agree disagree. I one hundred percent agree. I mean i think the biggest thing was with a lot of companies in whether it's an agency obviously we've got a fair amount of agency owners probably about half. The people filled out the survey agency owners. Which is which is fine. That's that's the type of listener that we tend to attract digital. Marker obviously has a very strong agency presence by serving agencies. You know who. The host of the show is an agency owner. You're an agency on herself makes sense but processing systems aren't agency specific. It's as you are growing out team whether it's building traffic or whether you're doing it on your own as a ceo or as a founder as business owner as a cmo like you eventually want somebody to be able to do it for you or to have a team of people to do it for you. Some people hire agencies to do that. Or they have internal people that they hire and then those systems that they have in place and of helping them run the ads or do whatever. The process is for businesses in order to scale and grow because at the end of the day like scaling and growing what a business really does want to do and obviously deliver value along the way to keep those customers and you know to have them coming back for more each and every time the point is systems and processes are big big part of the success of any business whether or not it's agency or otherwise.

facebook Marker one about half tirr eleven one hundred percent two things God each things themes eight
"kasim" Discussed on Perpetual Traffic by DigitalMarketer

Perpetual Traffic by DigitalMarketer

04:51 min | 1 year ago

"kasim" Discussed on Perpetual Traffic by DigitalMarketer

"Host ralph burns and this is episode three hundred and eleven and i am here alongside a past. Yes to perpetual traffic. One man the episode that he did this one of our most popular episodes and apparently people liked what he had to say not only because he talks with wicked fast but he's wicked smart and he brings a lot to the table here at perpetual traffic and we only invite smart people onto the show really. I think he falls right in the middle of that. Really happy to have qassem ozlem. I had two practices name like twenty times last night before. I went to bed to make sure that i said it right. I think i got it right. But welcome back to perpetual traffic qassem. Cervix senator be here. Have you bet so Anyway so cost some that. We're just gonna make sure as in awesome so he's.

one Cervix two practices qassem ozlem twenty last night before ralph qassem One man and eleven popular episodes episode three hundred times
Using Computational Discovery to Build Better Immunotherapies

The Bio Report

08:04 min | 1 year ago

Using Computational Discovery to Build Better Immunotherapies

"Team. Thanks for joining us dan. We're gonna talk about immunotherapy compuserve and its efforts to pursue novel targets for ahmed cancer types. Perhaps we can been gin with the idea of checkpoint inhibitors what are they. And how do they work. He'd be taurus. Are actually proteins modulating the immune system responds in the context of fay affair. Kasim yuna therapy. It was identified. There is a crosstalk between immune cells and and the cancer. This crosstalk is being done through immune checkpoint and and usually these are inhibiting the immune system response to the to the cancer to the cancer cells and and the drugs the few drugs that are out there that are dressing these same immune checkpoint skin to treat cancer. Patients are actually am inhibiting. The inhibition exerted by immune checkpoint on the cancer cells in diff- therefore allowing the immune system to be stimulated and actually fight the cancer. This has been a a real revolution in cancer. Care but these still have limited efficacy. How how effective are these therapies at treating cancer today as of today about twenty to thirty percent of the patient population of the cancer patients are responsive to these drugs. It is increasing with time. We're more proven are being done with the current in hebrew tours. But i have to say that you know. Cancer is a movie factoria disease and and it's actually a collection of many different diseases and we're not in a situation where one treatment fits all basically declined immune checkpoint a drugs are addressing only few number drug targets and they're still many mechanisms that need to be a still a explored and and identified and drugs need to be developed in order to address the various mechanisms of action by which the kansas are actually avoiding the immune system. And here's actually that were. Competent fits in and see what we do. Discover new drug targets and developer first in class drugs to address. These struck targets copy. Jen has developed a computational based drug discovery platform. What is the platform. And how does it work. So the platform is is basically based on twenty years a fan and know how that was built at computation with being a computational discovery company for many years and then after we established a critical mass of discovery capabilities. We turn to be to. We are today. Pretty discovery and development company in generale with built computer systems tucson algorithms in order to be able to address the challenge of new drug targets discovery. And you biological halfway discovery. Identify new drug targets is a is a is a very complex isn't f. fourteens. Multiday mentioned effort and for that we had to develop a multiple systems. We've built a lot of know-how in the company and we've built a Expertise in what is called multi onyx analysis. We're not limiting our platform to a specific data type or a specific technology. Actually we're very flexible. Tools and systems an algorithms are really designed to address multiple data sources multiple data technologies and. This is because this is multifactorial and complex and filled to work in. An all of these are augmented with human expertise that we have in the company in the last twenty years. How do the targets. You've discovered differ from the targets that today's checkpoint inhibitors go after and it's very good question. Actually it's not very different in terms of you know still it's checkpoint but i think that the nature of checkpoints one as compared to the others those that are known and those that we discovered these are proteins. That are very different from one. Another so yes all of them. At least those are defined as negative customer tour costing military checkpoints. They're all inhibiting the immune system response against the cancer. But they're doing it in different ways and what we discovered is as i said you know the checkpoints are now have been translated to drugs that are in the market. A really only very few. I think about three or sociology for pd one. Pedia want and what we discovered. Is you know you biological pathways debts allowed us to discover new immune. Checkpoint that are still inhibiting the immune system response against the cancer but in a different way a different mechanism and this allows us to be able to develop hopefully no new treatments solutions. That will address those cancer patients the not responsive to the current checkpoint inhibitors check on earth. What are the issues with. Existing immunotherapy is the ability of cancers to develop resistance. Where are you doing to address that issue so this is actually exactly what we're trying to do. Am that in cancer. Immunotherapy is there are two issues right there. Ease the patients that are not responsive in does that with time that are developing what is called acquired resistance. We're we're trying to do in. The company is to try and focus on those biological pathways that we believe would address those patients that are not responsive to the current checkpoint blockade. So they're in different ways with different. Mechanism does cancers data and actually deliver a different solution to the problem. And this will were trying to work on. You know the leading the leading drug that is in development at is now owning phase one studies and we have owning michel data in the clinic but the days actually am supporting designs behind. We discovered so we discovered a completely new biological pathway identified sen typically that it is addressing am in. You am a new mechanism that still this family of immune checkpoint. The preclinical data suggested that it should address

Cancers Kasim Yuna FAY Generale DAN JEN Kansas Tucson Michel
The Mystery Of The Mummified Twinkie

Short Wave

07:52 min | 2 years ago

The Mystery Of The Mummified Twinkie

"Colin purring in Pennsylvania wanted the world to know about his accidental fungal experiments involving twinkies. So what happened next? So he posted photos on twitter and they were seen by two scientists, Brian Love it and Matt Casson at West Virginia University, they study Fungi Casson says fungi are everywhere and they have this amazing ability to break down all kinds of substances. Fungi growing on jet fuel. Wow. So he means fungi can grow on pretty much anything and everything. Yeah and in the past their lab has tested how well they grow in peeps. You know that classic marshmallow tree tour hasn't says fungi found the peace challenging because you know they don't have a lot of water in them in a way they're kind of like an extreme environment, right? The food industry has crafted the ability to to make foods that have a long shelf life. You know I could test that out right now I got some old peeps in my house my kid. Kept from Easter like years ago. But anyway back to the twinkies. So these researchers were intrigued by Collins Posts on twitter and Colin was only too happy to mail his twinkies right to their lab. They suspected that whatever had mummified the twinkie was some kind of fungus but they wanted to confirm that and then find out exactly what kind of fungus. Okay. So twinkie mummy gets shipped to the lab obviously, they had to open it up. I'm guessing and as I look at the photo, the plastic wrapping around the shriveled twinkie looks like it's been vacuum-sealed like it sucked inward like. Right right. So the scientists thought maybe the fungus got in before the package was sealed, and then as it grew the fungus was using up more air or oxygen than it was putting out I mean, here's how love it described it. You end up with a document. And very well, vacuum may have halted. The fungus is ability to continue to grow We have the snapshot of what we were sent but who knows if this process occurred five years ago and he just only noticed it now yeah five years that's forty times the shelf life of a twinkie in eternity for twinkie anyway they had expected this horrific smelled hit them. When they opened the packaging, the smell would possibly kill one of us. But because of them of -cation there there really was no smell at all, which was really a pleasant surprise. So twinkie mommy is unwrapped smells like nothing what happened next? Well, they took a quick look with a magnifying scope and Juhasz some signs of fungal spore formation on the twinkie. So that suggested a fungus of some kind and the next step was to take a sample. So casting used a bone biopsy tool to sort of drill through the tough outer layer of this grey mummified twinkie, we certainly hit the marrow of the twinkie and quickly realized that there was still some. Cream filling on the inside. So, the inside was still cream-filled. Yeah that was a surprise they thought it would be sort of hard all the way through of it says, whatever did this to the twinkie it seems that the fungus was more interested in the cake on the outside. Then the filling on the inside see, this is a smart fungus because cake is clearly the superior part of the twinkie same with Orios same with cupcakes. You know what I'm talking about right now I don't know to me. It's like the combination of two things that's key. So I can't really separate them in my mind. That's fair I. Accept that. So the scientists have taken samples from the twinkie, do they go about determining what kind of fungus growing on it? They actually sampled multiple twinkies. Okay. So one was the mummified twinkie we've been talking about the other was the second twinkie from Collins box that was not mummified. The one that was just you know marred, it had that weird little blemish on the outside of it, and then they had this control scientific experiment they need scientific control, which was a what they called an as symptomatic twinkie from the same box. So they put those samples into lab dishes with nutrients commonly used to grow fungi, and from that little blemish twinkie the one. With just the little. Marc, they were able to grow a very common indoor fungus called Klee does sport him common indoor fungus, right? It's one of the most common airborne molds worldwide. Okay. So what about from the mummified twinkie? Okay. So that's where it gets even more interesting. Love. It says, they have not been able to grow any fungus from that particular sample. It may be that we don't have any living spores on store certainly dying depending on the fungus they could I very quickly and remember because the twinkie had been sort of vacuum sealed by whatever was going on there. You know it seems like it couldn't grow anymore inside it's wrapping. So there's truly perhaps no life in this twinkie. Well, the scientists you know weren't going to let that stop them they. Samples from both the marred and the mummified twinkies and he sent off to DNA sequencing company and twelve hours. Later, they got the results back the mark twinkie was a ninety nine point six percent matched to a fungus called close Boreham zeile film. The mummified twinkie was eighty one percent to a closely related clear does for him species. Plato's Boreham Tenuous Sim. CASSON's says DNA from the mummified twinkie was pretty degraded. So they actually probably are the same fungus. I'm so amazed they were able to identify these fungi from these twinkies. It is the mystery of the twinkie over I remain confident that science will continue already one researcher Kate Wallace at the University of Illinois contacted them and asked for a bit of the mummified that she wants to put in a scanning electron microscope. One that can get really really close. Up Images and hopefully you know see something cool and Kasim says he's not turning his lab entirely over to twinkie studies but you know they could still do some more research. We thought about inoculating some healthy twinkies with some cletus forum may be doing some transplants with the bone marrow biopsy tool where we replace a healthy plug with a fungus colonize plug. And see what happens from there. This twinkie line of research is just relentless. There's so many of questions still I mean what's the overall moral of the story here that you can try to hold onto the past but nothing gold can stay not even a twinkie well, that's one moral I mean another moral of the story is that Colin, purring ten should've listened to his mother and had more respect for expiration dates but you know people are really drawn to this myth that twinkies are immortal. I should mention we did reach out to hostess brands for comment on this story and I have not heard back from them at all You know the mummy twinkie is this different kind. Of disturbing vision of what the future could hold for twinkies and you know for all of us I mean Matt and says, this story seems to be gripping for people maybe because the grey mummified twinkie is such a dramatic contrast to this golden iconic twinkie that lives in our memories when those memories are tainted by like a visual reality like the twinkie experiment, we're kind of like caught off guard and we're like wait no, that's a symbol of my childhood. You can't take that from me to. So basically, like you said, emily, nothing lasts forever. You know here's Brian Love again, we're living in a time where we're all really grappling with our mortality eventually, all of us are future fungi. On. Seeing. That is sort of facing the the reality. Of. Holly and Our destination now, I did not expect a twinkie experiment to be a meditation on the human. Condition

Fungi Casson Colin Brian Love Twitter Pennsylvania Hostess Brands West Virginia University Plato Collins Orios Emily University Of Illinois Holly Marc Kasim Researcher
The Mystery Of The Mummified Twinkie

Short Wave

07:52 min | 2 years ago

The Mystery Of The Mummified Twinkie

"Colin purring in Pennsylvania wanted the world to know about his accidental fungal experiments involving twinkies. So what happened next? So he posted photos on twitter and they were seen by two scientists, Brian Love it and Matt Casson at West Virginia University, they study Fungi Casson says fungi are everywhere and they have this amazing ability to break down all kinds of substances. Fungi growing on jet fuel. Wow. So he means fungi can grow on pretty much anything and everything. Yeah and in the past their lab has tested how well they grow in peeps. You know that classic marshmallow tree tour hasn't says fungi found the peace challenging because you know they don't have a lot of water in them in a way they're kind of like an extreme environment, right? The food industry has crafted the ability to to make foods that have a long shelf life. You know I could test that out right now I got some old peeps in my house my kid. Kept from Easter like years ago. But anyway back to the twinkies. So these researchers were intrigued by Collins Posts on twitter and Colin was only too happy to mail his twinkies right to their lab. They suspected that whatever had mummified the twinkie was some kind of fungus but they wanted to confirm that and then find out exactly what kind of fungus. Okay. So twinkie mummy gets shipped to the lab obviously, they had to open it up. I'm guessing and as I look at the photo, the plastic wrapping around the shriveled twinkie looks like it's been vacuum-sealed like it sucked inward like. Right right. So the scientists thought maybe the fungus got in before the package was sealed, and then as it grew the fungus was using up more air or oxygen than it was putting out I mean, here's how love it described it. You end up with a document. And very well, vacuum may have halted. The fungus is ability to continue to grow We have the snapshot of what we were sent but who knows if this process occurred five years ago and he just only noticed it now yeah five years that's forty times the shelf life of a twinkie in eternity for twinkie anyway they had expected this horrific smelled hit them. When they opened the packaging, the smell would possibly kill one of us. But because of them of -cation there there really was no smell at all, which was really a pleasant surprise. So twinkie mommy is unwrapped smells like nothing what happened next? Well, they took a quick look with a magnifying scope and Juhasz some signs of fungal spore formation on the twinkie. So that suggested a fungus of some kind and the next step was to take a sample. So casting used a bone biopsy tool to sort of drill through the tough outer layer of this grey mummified twinkie, we certainly hit the marrow of the twinkie and quickly realized that there was still some. Cream filling on the inside. So, the inside was still cream-filled. Yeah that was a surprise they thought it would be sort of hard all the way through of it says, whatever did this to the twinkie it seems that the fungus was more interested in the cake on the outside. Then the filling on the inside see, this is a smart fungus because cake is clearly the superior part of the twinkie same with Orios same with cupcakes. You know what I'm talking about right now I don't know to me. It's like the combination of two things that's key. So I can't really separate them in my mind. That's fair I. Accept that. So the scientists have taken samples from the twinkie, do they go about determining what kind of fungus growing on it? They actually sampled multiple twinkies. Okay. So one was the mummified twinkie we've been talking about the other was the second twinkie from Collins box that was not mummified. The one that was just you know marred, it had that weird little blemish on the outside of it, and then they had this control scientific experiment they need scientific control, which was a what they called an as symptomatic twinkie from the same box. So they put those samples into lab dishes with nutrients commonly used to grow fungi, and from that little blemish twinkie the one. With just the little. Marc, they were able to grow a very common indoor fungus called Klee does sport him common indoor fungus, right? It's one of the most common airborne molds worldwide. Okay. So what about from the mummified twinkie? Okay. So that's where it gets even more interesting. Love. It says, they have not been able to grow any fungus from that particular sample. It may be that we don't have any living spores on store certainly dying depending on the fungus they could I very quickly and remember because the twinkie had been sort of vacuum sealed by whatever was going on there. You know it seems like it couldn't grow anymore inside it's wrapping. So there's truly perhaps no life in this twinkie. Well, the scientists you know weren't going to let that stop them they. Samples from both the marred and the mummified twinkies and he sent off to DNA sequencing company and twelve hours. Later, they got the results back the mark twinkie was a ninety nine point six percent matched to a fungus called close Boreham zeile film. The mummified twinkie was eighty one percent to a closely related clear does for him species. Plato's Boreham Tenuous Sim. CASSON's says DNA from the mummified twinkie was pretty degraded. So they actually probably are the same fungus. I'm so amazed they were able to identify these fungi from these twinkies. It is the mystery of the twinkie over I remain confident that science will continue already one researcher Kate Wallace at the University of Illinois contacted them and asked for a bit of the mummified that she wants to put in a scanning electron microscope. One that can get really really close. Up Images and hopefully you know see something cool and Kasim says he's not turning his lab entirely over to twinkie studies but you know they could still do some more research. We thought about inoculating some healthy twinkies with some cletus forum may be doing some transplants with the bone marrow biopsy tool where we replace a healthy plug with a fungus colonize plug. And see what happens from there. This twinkie line of research is just relentless. There's so many of questions still I mean what's the overall moral of the story here that you can try to hold onto the past but nothing gold can stay not even a twinkie well, that's one moral I mean another moral of the story is that Colin, purring ten should've listened to his mother and had more respect for expiration dates but you know people are really drawn to this myth that twinkies are immortal. I should mention we did reach out to hostess brands for comment on this story and I have not heard back from them at all You know the mummy twinkie is this different kind. Of disturbing vision of what the future could hold for twinkies and you know for all of us I mean Matt and says, this story seems to be gripping for people maybe because the grey mummified twinkie is such a dramatic contrast to this golden iconic twinkie that lives in our memories when those memories are tainted by like a visual reality like the twinkie experiment, we're kind of like caught off guard and we're like wait no, that's a symbol of my childhood. You can't take that from me to. So basically, like you said, emily, nothing lasts forever. You know here's Brian Love again, we're living in a time where we're all really grappling with our mortality eventually, all of us are future fungi. On. Seeing. That is sort of facing the the reality. Of. Holly and Our destination now, I did not expect a twinkie experiment to be a meditation on the human. Condition

Fungi Casson Colin Brian Love Twitter Pennsylvania Hostess Brands West Virginia University Plato Collins Orios Emily University Of Illinois Holly Marc Kasim Researcher
The Mystery Of The Mummified Twinkie

Short Wave

07:52 min | 2 years ago

The Mystery Of The Mummified Twinkie

"Colin purring in Pennsylvania wanted the world to know about his accidental fungal experiments involving twinkies. So what happened next? So he posted photos on twitter and they were seen by two scientists, Brian Love it and Matt Casson at West Virginia University, they study Fungi Casson says fungi are everywhere and they have this amazing ability to break down all kinds of substances. Fungi growing on jet fuel. Wow. So he means fungi can grow on pretty much anything and everything. Yeah and in the past their lab has tested how well they grow in peeps. You know that classic marshmallow tree tour hasn't says fungi found the peace challenging because you know they don't have a lot of water in them in a way they're kind of like an extreme environment, right? The food industry has crafted the ability to to make foods that have a long shelf life. You know I could test that out right now I got some old peeps in my house my kid. Kept from Easter like years ago. But anyway back to the twinkies. So these researchers were intrigued by Collins Posts on twitter and Colin was only too happy to mail his twinkies right to their lab. They suspected that whatever had mummified the twinkie was some kind of fungus but they wanted to confirm that and then find out exactly what kind of fungus. Okay. So twinkie mummy gets shipped to the lab obviously, they had to open it up. I'm guessing and as I look at the photo, the plastic wrapping around the shriveled twinkie looks like it's been vacuum-sealed like it sucked inward like. Right right. So the scientists thought maybe the fungus got in before the package was sealed, and then as it grew the fungus was using up more air or oxygen than it was putting out I mean, here's how love it described it. You end up with a document. And very well, vacuum may have halted. The fungus is ability to continue to grow We have the snapshot of what we were sent but who knows if this process occurred five years ago and he just only noticed it now yeah five years that's forty times the shelf life of a twinkie in eternity for twinkie anyway they had expected this horrific smelled hit them. When they opened the packaging, the smell would possibly kill one of us. But because of them of -cation there there really was no smell at all, which was really a pleasant surprise. So twinkie mommy is unwrapped smells like nothing what happened next? Well, they took a quick look with a magnifying scope and Juhasz some signs of fungal spore formation on the twinkie. So that suggested a fungus of some kind and the next step was to take a sample. So casting used a bone biopsy tool to sort of drill through the tough outer layer of this grey mummified twinkie, we certainly hit the marrow of the twinkie and quickly realized that there was still some. Cream filling on the inside. So, the inside was still cream-filled. Yeah that was a surprise they thought it would be sort of hard all the way through of it says, whatever did this to the twinkie it seems that the fungus was more interested in the cake on the outside. Then the filling on the inside see, this is a smart fungus because cake is clearly the superior part of the twinkie same with Orios same with cupcakes. You know what I'm talking about right now I don't know to me. It's like the combination of two things that's key. So I can't really separate them in my mind. That's fair I. Accept that. So the scientists have taken samples from the twinkie, do they go about determining what kind of fungus growing on it? They actually sampled multiple twinkies. Okay. So one was the mummified twinkie we've been talking about the other was the second twinkie from Collins box that was not mummified. The one that was just you know marred, it had that weird little blemish on the outside of it, and then they had this control scientific experiment they need scientific control, which was a what they called an as symptomatic twinkie from the same box. So they put those samples into lab dishes with nutrients commonly used to grow fungi, and from that little blemish twinkie the one. With just the little. Marc, they were able to grow a very common indoor fungus called Klee does sport him common indoor fungus, right? It's one of the most common airborne molds worldwide. Okay. So what about from the mummified twinkie? Okay. So that's where it gets even more interesting. Love. It says, they have not been able to grow any fungus from that particular sample. It may be that we don't have any living spores on store certainly dying depending on the fungus they could I very quickly and remember because the twinkie had been sort of vacuum sealed by whatever was going on there. You know it seems like it couldn't grow anymore inside it's wrapping. So there's truly perhaps no life in this twinkie. Well, the scientists you know weren't going to let that stop them they. Samples from both the marred and the mummified twinkies and he sent off to DNA sequencing company and twelve hours. Later, they got the results back the mark twinkie was a ninety nine point six percent matched to a fungus called close Boreham zeile film. The mummified twinkie was eighty one percent to a closely related clear does for him species. Plato's Boreham Tenuous Sim. CASSON's says DNA from the mummified twinkie was pretty degraded. So they actually probably are the same fungus. I'm so amazed they were able to identify these fungi from these twinkies. It is the mystery of the twinkie over I remain confident that science will continue already one researcher Kate Wallace at the University of Illinois contacted them and asked for a bit of the mummified that she wants to put in a scanning electron microscope. One that can get really really close. Up Images and hopefully you know see something cool and Kasim says he's not turning his lab entirely over to twinkie studies but you know they could still do some more research. We thought about inoculating some healthy twinkies with some cletus forum may be doing some transplants with the bone marrow biopsy tool where we replace a healthy plug with a fungus colonize plug. And see what happens from there. This twinkie line of research is just relentless. There's so many of questions still I mean what's the overall moral of the story here that you can try to hold onto the past but nothing gold can stay not even a twinkie well, that's one moral I mean another moral of the story is that Colin, purring ten should've listened to his mother and had more respect for expiration dates but you know people are really drawn to this myth that twinkies are immortal. I should mention we did reach out to hostess brands for comment on this story and I have not heard back from them at all You know the mummy twinkie is this different kind. Of disturbing vision of what the future could hold for twinkies and you know for all of us I mean Matt and says, this story seems to be gripping for people maybe because the grey mummified twinkie is such a dramatic contrast to this golden iconic twinkie that lives in our memories when those memories are tainted by like a visual reality like the twinkie experiment, we're kind of like caught off guard and we're like wait no, that's a symbol of my childhood. You can't take that from me to. So basically, like you said, emily, nothing lasts forever. You know here's Brian Love again, we're living in a time where we're all really grappling with our mortality eventually, all of us are future fungi. On. Seeing. That is sort of facing the the reality. Of. Holly and Our destination now, I did not expect a twinkie experiment to be a meditation on the human. Condition

Fungi Casson Colin Brian Love Twitter Pennsylvania Hostess Brands West Virginia University Plato Collins Orios Emily University Of Illinois Holly Marc Kasim Researcher
The Mystery Of The Mummified Twinkie

Short Wave

07:52 min | 2 years ago

The Mystery Of The Mummified Twinkie

"Colin purring in Pennsylvania wanted the world to know about his accidental fungal experiments involving twinkies. So what happened next? So he posted photos on twitter and they were seen by two scientists, Brian Love it and Matt Casson at West Virginia University, they study Fungi Casson says fungi are everywhere and they have this amazing ability to break down all kinds of substances. Fungi growing on jet fuel. Wow. So he means fungi can grow on pretty much anything and everything. Yeah and in the past their lab has tested how well they grow in peeps. You know that classic marshmallow tree tour hasn't says fungi found the peace challenging because you know they don't have a lot of water in them in a way they're kind of like an extreme environment, right? The food industry has crafted the ability to to make foods that have a long shelf life. You know I could test that out right now I got some old peeps in my house my kid. Kept from Easter like years ago. But anyway back to the twinkies. So these researchers were intrigued by Collins Posts on twitter and Colin was only too happy to mail his twinkies right to their lab. They suspected that whatever had mummified the twinkie was some kind of fungus but they wanted to confirm that and then find out exactly what kind of fungus. Okay. So twinkie mummy gets shipped to the lab obviously, they had to open it up. I'm guessing and as I look at the photo, the plastic wrapping around the shriveled twinkie looks like it's been vacuum-sealed like it sucked inward like. Right right. So the scientists thought maybe the fungus got in before the package was sealed, and then as it grew the fungus was using up more air or oxygen than it was putting out I mean, here's how love it described it. You end up with a document. And very well, vacuum may have halted. The fungus is ability to continue to grow We have the snapshot of what we were sent but who knows if this process occurred five years ago and he just only noticed it now yeah five years that's forty times the shelf life of a twinkie in eternity for twinkie anyway they had expected this horrific smelled hit them. When they opened the packaging, the smell would possibly kill one of us. But because of them of -cation there there really was no smell at all, which was really a pleasant surprise. So twinkie mommy is unwrapped smells like nothing what happened next? Well, they took a quick look with a magnifying scope and Juhasz some signs of fungal spore formation on the twinkie. So that suggested a fungus of some kind and the next step was to take a sample. So casting used a bone biopsy tool to sort of drill through the tough outer layer of this grey mummified twinkie, we certainly hit the marrow of the twinkie and quickly realized that there was still some. Cream filling on the inside. So, the inside was still cream-filled. Yeah that was a surprise they thought it would be sort of hard all the way through of it says, whatever did this to the twinkie it seems that the fungus was more interested in the cake on the outside. Then the filling on the inside see, this is a smart fungus because cake is clearly the superior part of the twinkie same with Orios same with cupcakes. You know what I'm talking about right now I don't know to me. It's like the combination of two things that's key. So I can't really separate them in my mind. That's fair I. Accept that. So the scientists have taken samples from the twinkie, do they go about determining what kind of fungus growing on it? They actually sampled multiple twinkies. Okay. So one was the mummified twinkie we've been talking about the other was the second twinkie from Collins box that was not mummified. The one that was just you know marred, it had that weird little blemish on the outside of it, and then they had this control scientific experiment they need scientific control, which was a what they called an as symptomatic twinkie from the same box. So they put those samples into lab dishes with nutrients commonly used to grow fungi, and from that little blemish twinkie the one. With just the little. Marc, they were able to grow a very common indoor fungus called Klee does sport him common indoor fungus, right? It's one of the most common airborne molds worldwide. Okay. So what about from the mummified twinkie? Okay. So that's where it gets even more interesting. Love. It says, they have not been able to grow any fungus from that particular sample. It may be that we don't have any living spores on store certainly dying depending on the fungus they could I very quickly and remember because the twinkie had been sort of vacuum sealed by whatever was going on there. You know it seems like it couldn't grow anymore inside it's wrapping. So there's truly perhaps no life in this twinkie. Well, the scientists you know weren't going to let that stop them they. Samples from both the marred and the mummified twinkies and he sent off to DNA sequencing company and twelve hours. Later, they got the results back the mark twinkie was a ninety nine point six percent matched to a fungus called close Boreham zeile film. The mummified twinkie was eighty one percent to a closely related clear does for him species. Plato's Boreham Tenuous Sim. CASSON's says DNA from the mummified twinkie was pretty degraded. So they actually probably are the same fungus. I'm so amazed they were able to identify these fungi from these twinkies. It is the mystery of the twinkie over I remain confident that science will continue already one researcher Kate Wallace at the University of Illinois contacted them and asked for a bit of the mummified that she wants to put in a scanning electron microscope. One that can get really really close. Up Images and hopefully you know see something cool and Kasim says he's not turning his lab entirely over to twinkie studies but you know they could still do some more research. We thought about inoculating some healthy twinkies with some cletus forum may be doing some transplants with the bone marrow biopsy tool where we replace a healthy plug with a fungus colonize plug. And see what happens from there. This twinkie line of research is just relentless. There's so many of questions still I mean what's the overall moral of the story here that you can try to hold onto the past but nothing gold can stay not even a twinkie well, that's one moral I mean another moral of the story is that Colin, purring ten should've listened to his mother and had more respect for expiration dates but you know people are really drawn to this myth that twinkies are immortal. I should mention we did reach out to hostess brands for comment on this story and I have not heard back from them at all You know the mummy twinkie is this different kind. Of disturbing vision of what the future could hold for twinkies and you know for all of us I mean Matt and says, this story seems to be gripping for people maybe because the grey mummified twinkie is such a dramatic contrast to this golden iconic twinkie that lives in our memories when those memories are tainted by like a visual reality like the twinkie experiment, we're kind of like caught off guard and we're like wait no, that's a symbol of my childhood. You can't take that from me to. So basically, like you said, emily, nothing lasts forever. You know here's Brian Love again, we're living in a time where we're all really grappling with our mortality eventually, all of us are future fungi. On. Seeing. That is sort of facing the the reality. Of. Holly and Our destination now, I did not expect a twinkie experiment to be a meditation on the human. Condition

Fungi Casson Colin Brian Love Twitter Pennsylvania Hostess Brands West Virginia University Plato Collins Orios Emily University Of Illinois Holly Marc Kasim Researcher
Problems with voting are widespread in parts of Atlanta metro

Red Eye Radio

00:20 sec | 2 years ago

Problems with voting are widespread in parts of Atlanta metro

"Houston voters reported long lines and problems with the Quitman Georgia Tuesday Democrats went to the polls to pick a nominee in the competitive U. S. Senate race there one of mayor Keisha lance bottoms and former mayor Kasim reed reported problems with voting machines not working long lines that started forming as soon as the polls

Georgia Keisha Lance Bottoms Houston Quitman Senate Kasim Reed
"kasim" Discussed on WBAP 820AM

WBAP 820AM

01:33 min | 2 years ago

"kasim" Discussed on WBAP 820AM

"Chokeholds he also said de escalation tactics are required and officers must issue warnings before firing their guns this Houston native welcomes the policies but says the issue goes deeper we believe we need to address systematic racism in all its forms this wall city and police leaders across the country works to implement change Clayton level Houston voters reported long lines and problems with the Quitman Georgia Tuesday Democrats went to the polls to pick a nominee in the competitive U. S. Senate race there one of mayor Keisha lance bottoms and former mayor Kasim reed reported problems with voting machines not working long lines that started forming as soon as the polls open hello ladies Tom Bedwell says he wants to prohibit displays of the Confederate battle flag move comes on the heels of the marine corps is ordering a similar policy incomes as the army has said it's open to renaming basis currently named after Confederate officers the chief of naval operations admiral Mike Gilday has directed his staff to begin crafting an order that would prohibit the Confederate battle flag from all public spaces and work areas aboard navy installations ships aircraft and submarines the commandant of the marine corps general David Berger issued a similar policy banning the display of the flag on installations back in April bill Michaels Washington Jerry Falwell junior his again under fire liberty university president deleted a tweet that showed one person in black face another in a clue Klux Klan hood and robe after black alumni and religious leaders spoke out against.

Georgia Keisha lance bottoms Tom Bedwell marine corps army Mike Gilday David Berger Jerry Falwell president Houston Quitman Senate Kasim reed chief of naval operations bill Michaels Washington liberty university
Long lines, voting machine problems fuel investigations in U.S. state of Georgia

Red Eye Radio

00:20 sec | 2 years ago

Long lines, voting machine problems fuel investigations in U.S. state of Georgia

"Houston voters reported long lines and problems with the Quitman Georgia Tuesday Mr Kranz went to the polls to pick a nominee in the competitive U. S. Senate race there one of mayor Keisha lance bottoms and former mayor Kasim reed reported problems with voting machines aren't working long lines that started forming as soon as the polls

Georgia Mr Kranz Keisha Lance Bottoms Houston Quitman Senate Kasim Reed
A Rare Disease Drug Hunter Turns His Attention to COVID-19

The Bio Report

05:35 min | 2 years ago

A Rare Disease Drug Hunter Turns His Attention to COVID-19

"As a medical student divvied Feigenbaum nearly died from castleman disease. A rare autoimmune condition he would suffer recurring bounce that carried him to the brink of death but was able to push the disease into remission by discovering drug. That could be re purposed to treat the disease. Feigenbaum co-founded the Castleman Disease Collaborative Network and developed a unique approach to research. That's now being adopted by other rare disease organizations. He tells the story in. His book chasing my cure when the Kobe. Nine thousand nine outbreak began vagabond recognized that the deadliest aspect of the disease hyperactive immune response known as a sign of kind storm sharing a common link with castleman disease. He hoped a researcher would apply his approach to finding a potential drug to repurpose to treat the virus and soon enlisted his own team to do so. We spoke to Feigenbaum Assistant. Professor at the Promo School of Medicine at the University of Pennsylvania Co founder and Executive Director of the Castleman Disease Collaborative Network about his own experience. How it led him to. Cova nineteen and his effort to help researchers and clinicians track all of the drugs being tried to treat the pandemic virus. David thanks for joining us. Dan thanks so much for having me. We're going to talk about the covert nineteen pandemic your research efforts. And how you're trying to do for Cova. Nineteen what you did for. Castle Man's disease listeners. Of our sister podcast rare cast will be familiar with you and your story but before we talk about covert nineteen and the work. You're doing there. I think it would be useful to start with your own experiences with Kasim's disease. This is a store you telling your book chasing my cure doctors race to turn hope into action which I recommend to all listeners. But let's start with you becoming ill in medical school. What happened so I went from training to become an oncologist? I had lost my mom to cancer. Just a few years before and wanted to exact revenge on cancer and I went from training to become an oncologist and being a healthy third year medical student to experiencing multi organ failure. My liver my kidneys. My Bone Marrow. My heart and my lungs began to shut down for an unknown reason. They hospitalized me and quickly sent me to the intensive care unit where I had a retinal hemorrhage that made me blind in my left eye against seventy pounds of fluid and I drifted in and out of consciousness for for months at a time I was eventually diagnosed with ideographic. Multicentric castleman disease. Which as you mentioned is a rare and deadly immune system disorder which unfortunately at the time had to be treated with chemotherapy. Because there were there were no other options and thankfully. Chemotherapy saved my life. But I was actually so sick right before. I received chemotherapy that I actually had my last rites read to me by priests because the doctors didn't think I would survive and really considered that moment to be the start of my overtime and time that I didn't think I would have but thankfully I survived with Chemo but unfortunately I would go on to have relapsed after relapse after relapse until I eventually found a drug that could save my life well listeners. Who Want to know that story in greater depth can go to the rare. Cast podcast and find the edition. We did with you. But what exactly did you do to find a drug that could be re purposed to treat castleman disease sure after the fourth time that I nearly died battling this disease and while I was actually on the only drug that has ever undergone randomized controlled trial for my disease in. That drug did not work. I realized I could no longer hope that some researchers somewhere would figure out a drug that could save me at this stage. I was a third year medical student so I I'd dove into the lab and I started doing laboratory. Experiments asserted foundation called the CASTLEMAN disease. Claver network and when I relapsed again about a year later I was in a position to collect samples on myself and store them so if I survived that I could perform experiments on those samples and thankfully chemotherapy saved my life again and I survived and I performed a series of experiments in the lab and looked at a number of data sets databases to be able to try to put together a pattern that I was observing and eventually found a particular communication line called the M. Tour pathway. Which is really important for Many cells in your body particularly immune cells to communicate with one another. I found that that was in a hyperactive state. And I thought well maybe if we can inhibit this particular communication line. Maybe that could save my life and There's a drug that's already. Fda approved that is called Sierra Lima so we began testing on me. And now it's been over six years that I've been in remission and this concept of what's called drug re purposing is a concept that's become Pretty widely recognized recently with Kovic nineteen. It's the idea that you can take a drug approved for something else in. It may have activity against a disease that no one ever thought was possible in in in this case. I'm living proof I'm chatting with you today and alive because of a drug those dog for completely different condition.

Castleman Disease Castleman Disease Collaborativ Researcher Feigenbaum Feigenbaum Assistant Cova Founder And Executive Director Relapse Kasim Sierra Lima DAN Promo School Of Medicine David University Of Pennsylvania Co FDA
Canadian special forces troops back on the job in Iraq, says commander

Monocle 24: The Globalist

00:18 sec | 2 years ago

Canadian special forces troops back on the job in Iraq, says commander

"Special forces back in Iraq they left last month following the assassination by the US of the Iranian military tree. General Kasim Suleimani and the Iraqi commander Abu Mahdi Al Mojaddedi. The Canadians were invited. Back the Iraqis to help track down what's left of. is but how long will they be. Therefore and they

Abu Mahdi Al Mojaddedi General Kasim Suleimani Iraq Commander United States
"kasim" Discussed on AP News

AP News

02:50 min | 2 years ago

"kasim" Discussed on AP News

"And Jim resorts anticipates cash proceeds of approximately two point four billion dollars it announced in October that was selling the real estate of allows you to a joint venture with Blackstone for about four point two five billion deals targeted to close in the first quarter are you a citizen claiming he was wrongfully imprisoned in Egypt has died after going on a hunger strike according to the state department A. P.'s my cabin reports he'd been locked up there for the last six years lawyers for fifty four year old Mustafa Kasam se died of heart failure Egypt's chief prosecutor is ordered an autopsy and investigation into the medical condition of Qassam any Gyptian born auto parts dealer from Long Island New York his lawyers say Kasim was arrested in Cairo and twenty thirteen when security forces descended on supporters of ousted president Mohammed Morsi Kasim was sentenced in twenty eighteen to fifteen years in prison under an anti protest law I'm my camp in there's some discord among Senate Republicans about what president trump the impeachment trial should look like the bees my grassy reports there are some who are now interested in calling witnesses the idea of a quick Senate vote to dismiss the articles of impeachment against president Donald Trump is being met with resistance on Monday senator Roy blunt of Missouri said GOP senators think both sides need to be heard along those lines Republican senator Susan Collins of Maine Mitt Romney of Utah and Lisa Murkowski of Alaska want the ground rules to include plans to eventually consider voting to call witnesses Senate Majority Leader Mitch McConnell remains opposed to calling witnesses but if just for GOP senators cross over and Democrats the United they could compel new testimony Mike Rossi up Washington impeachment action I'm Tim acquired with an A. P. newsman at the house post tomorrow to send the articles of impeachment against president trump to the Senate and the house speaker Nancy Pelosi's month long delay Senate minority leader Chuck Schumer says Senate Majority Leader Mitch McConnell has to call witnesses the American people know that a trial without witnesses and documents is not a real trial it's a sham trial and the American people will be able to tell the difference between a fair hearing of the fact and the cover up McConnell says the trial will start before any decision is made on calling witnesses we can't go there yet so we'll just have to wait and see what the what the feeling of the Senate is after listening to the arguments and the pit of written questions the trial is expected to get underway next Tuesday can Jennings has been crowned Japanese greatest of all time after beating fellow jeopardy legends James all sour and Brad Rutter in a series of matches that average roughly fifteen million viewers for ABC I'm Tim acquire AP digital news back in a moment thank you for listening.

AP Mike Rossi Tim Senate Nancy Pelosi Chuck Schumer Jennings James ABC Mitch McConnell GOP senator Susan Collins Maine Washington Brad Rutter Mohammed Morsi Kasim
US citizen dies in Egyptian prison after hunger strike

AP News Radio

00:32 sec | 2 years ago

US citizen dies in Egyptian prison after hunger strike

"Lawyers for fifty four year old Mustafa Kasam se died of heart failure Egypt's chief prosecutor is ordered an autopsy and investigation into the medical condition of Qassam any Gyptian born auto parts dealer from Long Island New York his lawyers say Kasim was arrested in Cairo in twenty thirteen when security forces descended on supporters of ousted president Mohammed Morsi Kasim was sentenced in twenty eighteen to fifteen years in prison under an anti protest law I'm my camp in

Egypt Prosecutor Long Island New York Cairo President Trump Mohammed Morsi Kasim
California ticket wins $522 million Mega Millions jackpot

WBZ Midday News

03:07 min | 4 years ago

California ticket wins $522 million Mega Millions jackpot

"The lunchtime numbers on Wall Street l. let's head over to Tracy jonky for Bloomberg business Tracy a bit of improvement on the Dow bet. Absolutely I mean Boeing is still all of accounts for all of the. Dow's lies at the moment and it's upside is led by Coca Cola so we've got mix here in the Dow is down. About forty seven points to twenty five thousand one hundred four it's no longer down one hundred NASDAQ's up thirty five points the SMP is up five and the Bloomberg WBZ Massachusetts index is higher by, three, quarters, percent, it's, rising, above, the, rest the Dow's lost again I'll Boeing and. Coca Cola topped its earnings estimates says no and low sugar drinks fueled it's global growth Diet cokes new skinny Kasim flavors. Helped out a lot coke launched, the redesigned cans and four new flavors in January and those new flavors made up about. A third of the brand's rebound in, recent, months homebuilder stocks, are, among, those, losing ground the Commerce Department says sales of. Do homes fell. To. An, eight month low in June business reports at eight and thirty eight past the hour I'm Tracy jonky Bloomberg. Business, on WBZ NewsRadio ten thirty WBZ news time. Twelve. Ten workers at the neck oh plant in revere has suddenly found themselves without a job round hill investments bought the business back in may. At an emergency auction and that company now confirms the plant has, closed down company says it has decided to sell. The brands to another. National manufacturer so far we haven't heard. Who this new owner is we also do not know if or when production will continue at. The plant now many of, the company's workers. Expected, the plan to stay open through November when. The plant's lease expires according to a worker. Talking to the Globe employees have not been or have been told not to show up for work and to come back on Friday to get their final paychecks and their personal belongings it's almost time for. Football with the season coming up we heard today from. Patriots coach Bill Belichick at the training camp press conference he was asked about. Julian, elements four-game suspension Gillian is a hard very hard working player world disappointed but it is what it, is he's moved on we've moved on Take. What we have now do this, we can when he was asked, about the. Benching of Malcolm Butler at the. Super Bowl. Didn't have much to say about that either simply answering, he's focused on this year season and last year. Is last year WBZ news time twelve eleven sports in. A minute but first this story a liquor store in San Jose California. Sold the, only winning. Ticket in last night's mega millions drawing it's worth more than half a, billion dollars before taxes, of course the winner has yet to come forward mass lotteries Christian teasha tells WBZ's Ben Parker couple, of ticket buyers here in Massachusetts also one big two there were two winning tickets sold in. Massachusetts for. It last night's drawing not the jackpot prize but there. Was a three million dollar winning ticket sold and east Boston zillions grocery, on Bennington street. And there was a one million dollar winning ticket. Sold at least supermarket fifteen eighty five com Evan Brighton. So a good night for a couple of mass residents and, we're hearing those winners have yet to come forward.

Bloomberg Wbz Massachusetts DOW Coca Cola Bill Belichick Patriots WBZ Boeing Tracy Jonky Bloomberg Malcolm Butler Tracy Jonky Bloomberg Massachusetts Tracy Commerce Department Revere Evan Brighton San Jose California
Bloomberg, Portugal and Donald Trump discussed on Balance of Nature

Balance of Nature

02:22 min | 4 years ago

Bloomberg, Portugal and Donald Trump discussed on Balance of Nature

"To the iowa border were again looking for heat indices in between ninety five one hundred degrees severe thunderstorms heavy rains and tornadoes are also possible today in the nation's midsection i'm ann cates and i'm susanna palmer from bloomberg world headquarters as we've been reporting a neighborhood beef was apparently behind a shooting early this morning in trenton to gunman opened fire at an all night arts and music festival art all night sending people running over each other in the scramble to safety one suspect was killed and twenty two people were injured among them a thirteen year old boy remains in critical condition three other people of the seventeen people treated for gunshot wounds are also said to be in critical condition mercer county prosecutor angelo offer free said a thirty three year old man was killed apparently by police and the second suspect is in custody ahead of this friday's meeting of the organization of petroleum exporting countries iran says three opec members will veto any increase in oil supply iran's opec representative hossain kasim poor ardabili in comments to bloomberg said we as ran and i hear iraq in venezuela are against any increase in opec production former white house strategist steve bannon said today that president donald trump doesn't have to justify his highly criticized policy of separating parents who enter the us illegally on the southern border with mexico from their children zerotolerance i don't think you have to justify why we have a crisis on the southern border bannon was speaking on abc this week the yield curve is a big deal and you might be right to be worried the treasury market yield curve which has been flattening and moving toward inversion a signal that has historically preceded recessions will be in focus this week traders will be on the lookout for any signals from policymakers of the fed who have speeches wind up in the us add european central bank conference in portugal the main event is an appearance by fed chair jerome powell global news twenty four hours a day on air and it ticked up on twitter powered by more than twenty seven hundred journalists and analysts more than one hundred twenty countries i'm susanna palmer this is bloomberg you're listening to bloomberg businessweek with carol massar and.

Bloomberg Portugal Donald Trump Steve Bannon Hossain Kasim Representative Opec Prosecutor Mercer County Bloomberg World Iowa Carol Massar Ann Cates Twitter Jerome Powell ABC Mexico United States President Trump