21 Burst results for "Kartini"

"kartini" Discussed on No Agenda

No Agenda

05:49 min | 1 year ago

"kartini" Discussed on No Agenda

"Hopefully we'll have a The big the big fourteen. Hundreds of big deal as an angel number Yes a very very good angel number casper's top of the list. One hundred eighty one dollars six days. Since from new. Brown's new brown fells texas bronxville new braunfels newborn full. That's how you pronounce it. The new bronco. You can put an acid the new braunfels. Yeah newborn phone calls. I can put an s. on the ended or not. You can new braunfels. I had a cooker from their their dynamite. They don't make them anymore. they're folded. I don't know what i'm talking about just making it up. Oh sorry go. he did. Send a handwritten note you so much for what you do is shining light. The darkness keeping good work. So i felt like i should read that. Also carl in donna posts from ridgeville pennsylvania. One hundred thirty three dollars sent in a note with a check. And i was hitting them out a couple of weeks ago by my husband and i have binge listened to twelve episodes and wanna say thank you binge. Listen i'm surprised you're still alive. The world is crazy. And i thought it was Alone until listening to the great podcast. Greatest podcast ever and what what happens. Is these birthing person producers. They turn out to be damn good. I got married. I got sarah. I got danny just one after another. They are researching. they're not sending frivolous stuff. It's all relevant. They got time codes. And we've never had this many women producing the show. Step it up dude. Step it up. Yeah guys being shut down but not tim. Tim denardo from cedar minnesota. He's in for one hundred dollars. Barron laeken hundred dollars john. Rogan at robot is malaysia's surge on ruben dollars. Speed skater in katy texas. Ninety six thirteen. Loretta vandenberg in providence saul louisiana eight eight fourth year clear. Mammogram wayne kartini in torrington connecticut. Seventy four twenty one shirl shirl andrews sixty one dollars with the birthday duke of luna lover of america in boobs comes with six zero six. He comes in a lot Either with the smaller the big big boobs resorts is moves. Moody's amanda horton with a birthday by six seven eight and she's over here in l. Sarah elsa bronte california used to be a lot of little farms elsa bronte. You could go out there and buy vegetables. And you'll be you'll be wishing for that. No more chris bailey. fifty five fifty six bren. Brian f- early but the five ten nickels on the tom. Dari same thing from deforest. Wisconsin fifty five ten sir william of west pencil pencil ta touchy fifty five ten andrew brewer in winston salem north carolina to five ten riley feted. But the to twenty seven with the birthday susan clay camp fifty twenty one in the following people fifty dollars donors name and location starting with ryan braun in hebron kentucky james share meta in nepomuk. New york sayers parman sayers harmon in asheville north. Sir luke the viscount of london and the south east in london. uk fifty done scalise in vernon connecticut. Joseph barnes in oakland fifty autumn brown. Olma in c- bring florida with a birthday And that's a fifty fifty s rita harrington in sparks nevada. Sir matthew ziskin chicago Michael white in sun valley arizona with an important note santan. This donation makes me a night. Please name me sir. Mike of parts to be determined. Thanks for the incredible bi weekly media deconstruction. You are more than welcome. Santan andrew oxen ham knoxville tennessee. I think he's asserted. Tyler davis king fisher. Oklahoma stephen tutt hill parts unknown known loretta vandenberg and provencal. Another one from provencal louisiana. We have a group. There haven't made up david beach in san antonio texas i h e kit ago on san francisco california sir brian watson in raleigh north carolina last. But not least sir. Brian brett farrell. I i believe he's an okay c. k. quick reached back to riley fetig He had the birthday call out from self but also douchebag. Call out for eric munoz hoops. Jesse fetig manny questions whether or not surpassed trich. Comber is overboard. He says thanks for all you do and continue. Hi do we do. And we have a staff of thousands Appreciate all of these producers and producers who came in under fifty dollars For reasons of anonymity or they are on one of our sustaining donations. Very important If you can keep those going it's always appreciated. We've got eleven eleven. Twelve twelve thirty three thirty three. You can find out all kinds of.

new braunfels Tim denardo cedar minnesota Barron laeken Loretta vandenberg providence saul bronxville wayne kartini shirl shirl andrews amanda horton texas ridgeville braunfels Sarah elsa bronte elsa bronte casper Brian f
"kartini" Discussed on No Agenda

No Agenda

05:49 min | 1 year ago

"kartini" Discussed on No Agenda

"Hopefully we'll have a The big the big fourteen. Hundreds of big deal as an angel number Yes a very very good angel number casper's top of the list. One hundred eighty one dollars six days. Since from new. Brown's new brown fells texas bronxville new braunfels newborn full. That's how you pronounce it. The new bronco. You can put an acid the new braunfels. Yeah newborn phone calls. I can put an s. on the ended or not. You can new braunfels. I had a cooker from their their dynamite. They don't make them anymore. they're folded. I don't know what i'm talking about just making it up. Oh sorry go a handwritten note you so much for. What you do is shining light. The darkness keeping good work. So i felt like i should read that. Also carl in donna posts from ridgeville pennsylvania. One hundred thirty three dollars sent in a note with a check. And i was hitting them out a couple of weeks ago by my husband and i have binge listened to twelve episodes and wanna say thank you binge. Listen i'm surprised you're still alive. The world is crazy. And i thought it was Alone until listening to the great podcast. Greatest podcast ever and what what happens. Is these birthing person producers. They turn out to be damn good. I got married. I got sarah. I got danny i. It's just one after another. They are researching. they're not sending frivolous stuff. It's all relevant. They got time codes. And we've never had this many women producing the show. Step it up dude. Step it up. Yeah guys being shut down but not tim. Tim denardo from cedar minnesota. He's in for one hundred dollars. Barron laeken hundred dollars john. Rogan at robot is malaysia's surge on ruben dollars. Speed skater in katy texas. Ninety six thirteen. Loretta vandenberg in providence saul louisiana eight eight fourth year clear. Mammogram wayne kartini in torrington connecticut. Seventy four twenty one shirl shirl andrews sixty one dollars with the birthday duke of luna lover of america in boobs comes with six zero six. He comes in a lot Either with the smaller. The big big boobs. It's it's it's is moves. Moody's amanda horton with a birthday by six seven eight and she's over here in l. Sarah elsa bronte california used to be a lot of little farms elsa bronte. You could go out there and buy vegetables. And you'll be you'll be wishing for that. No more chris bailey. fifty five fifty six bren. Brian f- early but the five ten nickels on the tom. Dari same thing from deforest. Wisconsin fifty five ten sir william of west pencil pencil ta touchy fifty five ten andrew brewer in winston salem north carolina to five ten riley feted at the to twenty seven with the birthday. Susan clay camp fifty twenty one in the following people fifty dollars donors name and location. Starting with ryan braun in hebron kentucky james share meta in nepomuk new york sayers parman sayers harmon in asheville north. Sir luke the viscount of london and the south east in london. uk fifty done scalise in vernon connecticut. Joseph barnes in oakland fifty autumn brown. Olma in c- bring florida with a birthday And that's a fifty fifty s rita harrington in sparks nevada. Sir matthew ziskin chicago Michael white in sun valley arizona with an important note santan. This donation makes me a night. Please name me sir. Mike of parts to be determined. Thanks for the incredible bi weekly media deconstruction. You are more than welcome. Santan andrew oxen ham knoxville tennessee. I think he's asserted. Tyler davis king fisher. Oklahoma stephen tutt hill parts unknown known loretta vandenberg and provencal. Another one from provencal louisiana. We have a group. There haven't made up david beach in san antonio texas i h e kit ago on san francisco california sir brian watson in raleigh north carolina last. But not least sir. Brian brett farrell. I n he's an okay c. k. quick reached back to riley fetig He had the birthday call out from self but also douchebag. Call out for eric munoz hoops. Jesse fetig manny questions whether or not surpassed trich. Comber is overboard. He says thanks for all you do and continue. Hi do we do. And we have a staff of thousands Appreciate all of these producers and producers who came in under fifty dollars For reasons of anonymity or they are on one of our sustaining donations. Very important If you can keep those going it's always appreciated. We've got eleven eleven. Twelve twelve thirty three thirty three. You can find out all kinds of.

new braunfels Tim denardo cedar minnesota Barron laeken Loretta vandenberg providence saul bronxville wayne kartini shirl shirl andrews amanda horton texas ridgeville braunfels Sarah elsa bronte elsa bronte casper Brian f
"kartini" Discussed on The Bio Report

The Bio Report

07:07 min | 1 year ago

"kartini" Discussed on The Bio Report

"Well kartini cell therapies have been a promising new area of cancer treatments there. Costly produced have had limited success in treating solid tumors and can carry sometimes serious side effects. Shoreline biosciences is developing off the shelf. Natural killer in macrophages cellular therapies derived from induced pluripotent stem cells for cancer inflammatory and genetic diseases. The company programs these cells to target and kill tumors as well as repair tissue homey of stasis. the company said its approach allows for the creation of a streamlined affordable and scalable manufacturing process. That can deliver self therapy treatments to patients faster and more cost effective manner. We spoke to clamp a sam topless co founder and ceo shoreline biosciences about the company's off the shelf self therapy's it's focused on the innate immune system and how it's leveraging its technology through recent partnerships with beijing. And kite pharma clamp is. Thanks for joining us. Thank danny presenting petition. We're going to talk about shoreline biosciences its platform for allergenic cell technology and two deals you announced in june that have propelled the company to hear. Perhaps we can begin with some of the challenges with cell therapy's today and how shoreline is addressing. Those what problems do you see your platform the a bigger question today. The look back the cell therapy's gaming to the to the attention of the broader community about a decade ago with some spectacular results using guy make onto receptor t. cells as immunotherapy. Those were found nearby incompetence. Like hide the juno. We sold response rate that we haven't seen before over sixty percent or so in in some severely. Ill basi- They came unfortunately with some significant side effects. graphs was close. Bbc's cytokine release syndrome which is very significant negative effect and other side effects that prevented the massive adoption of these lifesaving therapy so most of them continue to be a background of finally of specialized academic or other hospitals and have not yet reached the community Setting so of course The concept auto immune therapies based on the fact that in immune cell can be jamir armed in targeted in directed towards a tumor in not only of course officials which is the adopted part of the immunity over of humans but he told so being made part of the community constituting gremaldi from engaged cells san case for natural killer cells because there were identified the late seventies as cells that decade foreign invaders including of course Helps so our approach is fundamentally different. We working with different effector cells in shoreline is focusing on natural killer cells in macrophages. Would we know about natural killer cells that they have a lot of the benefits of the t. cells that have been used previously spectacular results. But they don guy the side effects that you see so we don't see graph. I we don't see our release syndrome. End in fact Recent clinical data with not repeal ourselves were implemented in community hospital setting so literally changing dramatically. That way we can deploy these lifesaving therapies variety of of Basis that need dodge the different between what we do and what the circle car companies are being now. Developing you genetically modified these cells. What's the intent of that modification. How does it make them more effective. At fighting cancers we condition them to become better athletes in in a sense. We make these cells to become more persistent once. We infused into into basi- And then we arm them. With specific targeting tools so that they can come to proximity of the of the tumors in allow them the natural killer cell the macrophage to do what they are designed to do. Which is to attack the tumor in in destroyed it. So they are genetic manipulations Doing that As i said conditioning them to persist longer to be metaphorically better fitted to kill more effectively. And then we arm them with guided missiles to find those. Those humors you say you are guided missiles to find the tumors. To what extent can these be targeted. What do you do to actually target them. Yeah wish start than. I should have died by that. From the beginning we have. It's mendes advantage in shorelines. Foundational expertise is based on reporter in stem cell biology and these comes from founders and over two decades of experience of really taking a button stem cells in finding ways to differentiate them into our effect or in k. nuts regular cells and macrophages sounds so blue balkan stem cells have the ability to defense eight into an over two hundred different cell types and in the process in old defense. Of course the difference differentiation protocols in conditions deploy it is in that process take pew report in stem cell. We engineer these is that we want to make it a better ultimately better athlete as i said in in this regard we make money relations in the beautiful in stem cell stage. We've been select the clone. That has a genetic money relation we got the is fema typically and typically and then we defense eighty dr in case l. stop becomes our bun that is then is a muster sell buying because the beauty of louboutins stem cells of course the clone expansion capabilities you can get millions of three themselves from a single cologne. And so we now have reservoir of genetically-modified best athletes that we deploy against the tumors. These are allergenic therapies. That you're developing. They don't have to be customized for a patient. What's the process..

tumors Shoreline biosciences cancer inflammatory sam topless co shoreline biosciences jamir cancer beijing danny Bbc fema
"kartini" Discussed on Behind the Bets

Behind the Bets

06:00 min | 1 year ago

"kartini" Discussed on Behind the Bets

"We talked about the home field advantage. This is going to be a raiders. Home game there was well for fans and chargers there so this house right was the rival. Absolutely i think. There's more raiders fans in los angeles than charters fan. I would've seen it we'll see. How just herbert does to try to get more fans on their side. A real quick quick note in college bryce young now the sole favorite to win the heisman a plus a quarter matt corral only drops to plus two thirty. Then it's double digits after that. If i told you you could have bama or georgia to win it all and i would take the field. Would you take it man. I'm still not sold on georgia's offense alabama's got a couple of questions there but it's so hard to go against either of those teams and nobody else is really third option. Yeah i would. I would cause even a team like iowa. We've seen these teams make ron's and they don't only score and the college football playoff. The georgian bama looked like a cut above particularly georgia to be honest and georgia's best even the country right now Just offensive georgia. Ten to one is my biggest regret of the season. I was at ten to one number. I almost took it and i opted not to ohio state oklahoma. I mean michigan. I was looking at michigan's numbers entering last week. And i regret not taking them alexander to win the title but you know you could get them at ten to one to win the big ten last week and they'll have to beat ohio state that for that to happen but michigan's looking a lot better than a lot of people thought the i think conference odds like i grabbed. Nc state before the clemson game at fifty to one to win the acc. i'm not taking college football futures. I mean they gotta get there and then win two games as double digit dogs. Some of these teams whether it's penn state whether it's iowa i dunno oregon if the committee looks past some of the maybe the bogus things like that. And even notre dame notre dame's one hundred one right now now obviously they lost but cincinnati is not gonna win two games the playoff. They're twenty five to one. I'll give someone fifty to one. They're not winning games What's what's happening. Partly if if you have an open parley. Cincinnati to win two playoff games. You might even get close at twenty five to one in starting it. They're not even the rest of regular season right. It's just now. Of course things could break certain way maybe alabama's the one seat in georgia's a four seat of alabama. Beat georgia in the sec. Title game then you'll to beat one of them as a big dog. Then it's a little different right. Maybe you catch. I dunno ohio state. In the semis. And that's more beatable for cincinnati just from the eye test through one month of the season. I mean we're obviously just spit spit ball on here. But it's crazy because i've been on some ridiculous tickets i was on. I had a notre dame ticket last year and there was nothing i could do besides hope that in in game halftime there tied or beating clemson and then play out of it that way. But it's really tough with the fourteen playoff now and these long shots and then this huge gap with the two this year. I can't remember two horse race like this with clemson. Excuse me bama and georgia than a big drop off after that. I'm sure that's happened recently. With some batman clemson with times. Ohio state often sneaks in. There is the clear third team. But but yeah. I mean college football pretty much every year. And you've got two or three teams. That are clear above everybody else and fading them as always very difficult very sad that the red sox came back and won because my Bluejays twenty eight to one to win. The pennant is dead so yankees and red sox do advance in their your wildcard teams. Anything we need to know about the baseball playoffs. Let the people know before this week. So the dodgers last. I checked their minus two thirteen. Which in the mlb wildcard which i believe goes back to twenty twelve. They'd be the second largest favorites in that game behind the yankees and 2017 against the twins. Yankees won that game. Dodgers are are still favor to win at all even though they're gonna you know in a one off coin flip game. So they're the they are the Plus three fifty. I believe last. I checked. So that's the shortest odds for a team entering the playoffs. Since in the wildcard era and with the third wild kartini favored to win the world series entering the playoffs along with the four red sox which were co favorites and the oh seven yankees so Something surprising i didn't realize to other teams also. I thought this was a special circumstance. Well that was also before they had to play the one though for near seven. That's before the one off wild card games. The coin flip wildcard game. Changes everything when it comes to. These is though clearly not with this dodgers team. Even though they can't even their division with the giants cashing their long tickets forty to one entering the year the giants win that division. That's the longest odds by eventual division winners since at least two thousand and as far back data and they went thirty two and a half games over their win. Total wintel seventy four and a half hundred seven wins since the ninety four ninety five strike the only team that's gone even twenty five games over. Its win total was the old one mariners which eighty four and a half winds and of course they one hundred and sixteen year so The for the giants are one of the biggest gambling surprises. We've seen in recent history in baseball. Well scherzer's on the bump as a dodger fan. That's all i could have wanted For the pitching the lineup. That way i love love bueller. Obviously kershaw scherzer's the guy want he's been lights out except for his last two outings of course field and then the regular season one. But i've confidence in him for sure he'll go against wainwright who's been. You know throwback season for him so cardinals red hot coming into the playoffs and dodgers will be fun. One that's on wednesday yankees and red sox on tuesday at the rest of the daily wager. Crew will have a preview of that. Monday tuesday when we get back to our weekday. Ten minute podcasts. A couple of other quick trends. Before i get outta here Rams have gone over the total and all four games this year. The steelers patriots and broncos have gone under the total in all four games. The chargers are also three in order the under so that clashes with the raiders trend. I mentioned earlier about their games. Going over The saints we mentioned earlier than losing outright. The underdog is now won outright in all four saints games this year and all four games have been at least ten points off the closing lines. So oddsmakers still can't figure out the saints..

georgia bryce young matt corral michigan alabama Nc state ohio dame notre dame yankees football clemson red sox iowa dodgers cincinnati raiders chargers herbert kartini acc
"kartini" Discussed on Cork's 96fm Opinion Line

Cork's 96fm Opinion Line

08:06 min | 1 year ago

"kartini" Discussed on Cork's 96fm Opinion Line

"To do a proper plan for people. This isn't exactly. And and i think that's what so many people were talking about today. And and cirque me. We'll i was asking questions about that kind of four month window. Why have we gotten to a place where we're at a four month window people you know like if you've been living somewhere for twenty five years like i i i'm i'm i'm i'm living in my house fifteen years and i'm very attached to it and i'd be very sad to leave. I can only imagine if somebody's living somewhere for twenty five years and you know they know their local shop and they they their local shopkeeper and they know their you know their local sober whatever it might be to move people on in that timeframe. Seems you know so difficult and i. I do question whether that's the best practice. Care plan for anybody who's been living in in a residential unit for for more than a decade or or however long. It might be and we did hear today actually. Interestingly the last the most recent person to come to own occur was only paster in february. Now that that seems extraordinary as well that she would play somebody in february in a building. Dass we heard today that they were the estates section of the. Hse was doing review in february around whether they should toasts building down. So you know. There's just so many questions here. I think a deferral would be a good outcome. It would give people time to do not to maybe find better placements. And maybe consider like what could be done while could be done to hold the service in middleton to keep people's quality of life there and the home that they know and whether that would be possible oregon. Thank you very much for being with us. Thanks so much. Green oregon speaking to me last evening of the week out that particular meeting yesterday and you heard other clips from the meeting including what the hate jesse had to say. They represented 'em by by their own community healthcare lead for cork and kerry michael fitzgerald and he said where they stand the latest for you starting to there seems to be a bulls coming for the members of the committee. Yesterday that at very least a deferral should be considered to behave jesse we have sent the. Hey chessy the audio of the interview with Nasa harrigan to see the response to us if you'd like to say anthon to it's about on correct this points at puppet into a voice message for what's up away. Three three nine thousand six ninety six nine thousand six. The opinion line on courts six. Fm tonight car. The insurance group hold them now for motor home business farm life on health insurance the g. e. sending best music mix day uncork ninety-six fm after news in cork. Sound better here. I've got the big change from all your favorite artists me. Justin bieber billy island. We'll stop in and everybody is always good for a price thank you. Thanks unreal and big name stars on the show for a chat joe. Cari us the on and this is my favorite place to play. You guys like a second are missing by car in the car. I work at home. Make sure you with me. Saw the murdoch day to four pm from cork's nineteen thousand six. Fm can't we just be opinion line. Pj coogan theban one five nine nine on porks six fm nine scramble for tickets. Ed sheeran and expected. Saturday go on sale at ticketmaster saturday eight. Am if you would like to win them before they go on sale. Win your way to see ed here in karak ninety-six six pm. On friday right eight. You can win them all day before you buy them all day. This friday. only on cork's ninety-six. Fm we live free tickets to give away for ed sheeran across the day this friday twenty fourth of september. Thanks to our friends at aitken promotion. That's coming up friday. Give giveaway on the opinion. I really wonder what other purposes that site could be put to and how the existing building was allowed to be run down the way it was even if there are excellent reasons for how we came to be here. I think you'll be far better. If the plants there had been told this might be a possibility and then another message that comes into my relative was moved to own a car after the february inspection and told it was his forever home. I'm disgusted at the cold and callous attitude of the. Hey jesse. yesterday they came unprepared because this is an organization that do what they want without caring for the residents net assigned d. Very important message does come into the opinion. I had this morning. My relative was moved on the kara after february inspection and told it was his forever home. Eighteen fifty seven one five nine six something else about which has been a tremendous a level of faffing about in the last couple of weeks is the america's cup the huge huge sporting event that could become into ireland in twenty twenty four and at one point thought over certain up against valencia in spain and Saudi arabia we. We thought we were at did search to get it and then the goldman seemed half afraid of it and then we heard of it costing one hundred and fifty million to bring it here and then we thought it was gone and then we thought it wasn't gone and lord knows what's happening at this stage. We know that Michael mcgrath administer for public. Expenditure kartini is concerned about the cost and concerned about the amount of public wanted that will have to put into it and it's his job to mind the public so presumably he. He's going through that it's dragging on a bit without an answer and make coggins good morning to you. Good morning peach pies for invite me on e. you're involved in this bid are you yes absolutely involves for two reasons one. I was involved from the start with kind of providing wind and waves days on the order information to team new zealand from there. Were kind of looking out at cork initially on the second really is because i just have such a vested interest in the sport and i see the huge positive switch would bring to the monster the hormones to reach him. I like haven't actually even believe that. Were where at this stage. Where i've had to go and set up a petition. Trying get this over the line it's It's it's it just beggars. Belief this to me is a complete no brainer. It just most go ahead fair enough but one would argue that a hundred and fifty million at a time when we need more hospitals more schools homes for people. It's a lot of money to be spending on sporting event. Yeah i hear you. Pj but that hundred and fifty million You know it's not. It's not a check that they're going to be writing at a water. It's going to be spread over. The whole duration of the event. Really and a lot of that. Money was allocated already anyway for the electric electric station of the year. The cork dakota rail line and other infrastructural jobs which we're going to have to be carried out anyway in order to prepare for the offshore wind farm turbine assembly Make that yes. Many of those things are in the program for government at and all that but the pandemic has.

paster Green oregon jesse kerry michael fitzgerald Nasa harrigan anthon ed sheeran billy island Pj coogan theban karak middleton Cari bulls Justin bieber oregon cork murdoch Michael mcgrath kartini
"kartini" Discussed on Rush Limbaugh Morning Update

Rush Limbaugh Morning Update

05:27 min | 1 year ago

"kartini" Discussed on Rush Limbaugh Morning Update

"Is there a bias. Is this an opinion. all dead. hold it hold it. When do we get that. When do we ever get a new show telling us of their bias and where certain story came from. What is this guy's a professor at the university of pennsylvania is the rest acted presentation of things and then the next bite is this Actually different different. It's not the same. That again was a university of pennsylvania. Professor michael kartini on msnbc yesterday the anchor babe malissa. Ray burger talking to democrats Flavia colgan maybe. It's flavia. i don't know. I i've never heard of pronounced. Ray berger says after you saw the path to nine eleven you upset. Abc didn't pull it all together or do the edited version. Make a difference absolutely not one. I think it undercuts the credibility of the film when you have it being released to rush limbaugh beforehand. Forty million dollars funding it. We don't know where it's coming from. Sandy berger and clinton were were well within their rights certainly to appeal. The tom kaine the reporting nine forty million dollars. We don't know where it came from how about. Abc it's an abc movie. Floppy of flavia touchstone put it out. I do have the dvd's it's irritates him so much they can't they can't get over this. They're beside themselves. With the fact that i got the dvd's but i wasn't the first fluffy of flavia. How many times have i got to say this..

university of pennsylvania michael kartini babe malissa Ray burger Flavia colgan Ray berger abc msnbc tom kaine Sandy berger rush limbaugh clinton flavia
"kartini" Discussed on Effectively Wild: A FanGraphs Baseball Podcast

Effectively Wild: A FanGraphs Baseball Podcast

06:30 min | 1 year ago

"kartini" Discussed on Effectively Wild: A FanGraphs Baseball Podcast

"Day for me like i'm sure. He is aware that he is the ultimate three true outcomes player in that he is like constantly setting three drought come rate records and so if he has all contact day where he actually has the run a little bit as a offensive player. Then yeah dimension. That doesn't escaped his notice entirely especially within the context of struggling more broadly. I imagine it doesn't right like he's just since he's come to new york it has not been. It hasn't gone quite the way that i imagine. Either he or the yankees. Were hoping that it would. And so i. I suspect that you are on the look. If for no other reason than you're hoping to see signs that you will be turning things around that you're very intimately aware of the sort of shape that your production is taking and keen to find something that will let you be able to say. I'm gonna i'm gonna turn a corner here. I'm i'm not a seventy five. Wrc plus hitter radar. I'm not a well i have. Maybe at times. Been a one thirty hitter. But i i not i. I'm not a guy who only hits six home runs. I haven't struck out forty percent of the time and many moons right so. I think that you're probably looking very carefully at what's going on so that you can sort of assure yourself that is getting better because you really nervous that it's going to get worse and so i bet i bet he knows i bet he knows. An an is taking note of the weirdness. Although i would also imagine that if you have a weird day that you might be able to sort of take that in stride a bit better than if it is an extreme version of the bad day you typically have that would probably make you feel the worst because really got us just not getting better. Yeah don't know if this is even a good sign for gallo because this is not his game when he is going well. He is striking out in walking in hitting overrun so for all i know like putting the ball in play as often as he apparently has lately or at least in. Those couple of games is a sign of something awry. No no got to start reading missing more. So yeah it's mess mar. I think he is. Yes but yeah maybe. Maybe it's a sign that he is like not in his usual group the as when he is going well he is inevitably going to do those things sometimes. So or maybe it's just random weird one of those things. Yep so here is a question from peter who says you've mentioned the recent epic sixteen inning. Padres dodgers game on the podcast. I watched the full game and like you enjoyed it very much. Thought the intentional bach by corey enable in the fifteenth inning was very interesting presumably can able was uncomfortable with victor kartini on second and pettis junior at bat. It was also very funny because he had to walk twice since time was called just before he dropped the ball for his first bach- attempt. I do not recall seeing an intentional bach. Before it's probably not recorded as intentional. So i assume there are no numbers available on how often it happens. In general field intentional bach is a good strategy in such a situation is signed stealing such a prominent thing that it's worth moving runner to third base interested to hear your thoughts as always so oh linked to the video but for those who didn't see it. Yeah able drop the ball literally. Like intentionally drought the paul. Just because he wanted to move the runner who was on second over the third ostensibly to prevent sign stealing of some sort. And this is not a i. This has happened multiple times in recent years in the majors. I don't know if it goes back further than that at that level. If you go to the wikipedia page for intentional box which does exist. It notes that the first known intentional bach in baseball which was attempted for reasons unrelated to science dealing came about in the nineteen fifty six claxton. Shield a multi team tournament in australia. Victoria and south australia were contesting the final game of the tournament. And the standings were such that the outcome of the tournament could be determined by run differential after playing to a tie in going into extra innings. South australia held a five to four lead entering the bottom of the twelfth inning. However they knew that a one run victory would not be enough to win the title on run differential when victoria had run around third base south australia tempted to allow that render to score in hopes of forcing another inning and then winning by more than a single run after a failed attempt at throwing the ball out of play. The south australia pitcher deliberately balked to try to send the runner home however the umpires ended the game and awarded at a nine. Nothing forfeit win for victoria. On the basis of south australia bringing the game into disrepute. That's a weird one and there's nothing on the intentional buck wikipedia page between the nineteen fifty-six claxton shield and twenty nineteen. When i think can we jansen did it and johnson. I think was doing it. Not for sign stealing related reasons but just because he found the runner distracting. I think it was jason heyward and you just didn't wanna have him there behind him. I guess and so he just balked him over to third but it happens. Evidently dodgers coach. Bob geren came up with the concept as sort of a assigned stealing prevention method that spring training and then can we. Jensen used it against the cubs in june of twenty nineteen. So hasn't been common. But it did happen with the cubs in craig kimbrel in. May he talked against the pirates and then in september just this week i think colin mchugh of the raise balked against the red sox intentionally in both of those were science doing related. So this is happening. And it's weird and i don't love it but if you're wondering why pitcher is intentionally sending the runner to third. That is why it is happening. This some of the w- the weirder risk behavior that we have witnessed in quite a while. 'cause i understand not wanting to have a guy communicate your signs but moving a runner to third.

victor kartini south australia yankees gallo dodgers pettis Padres corey new york claxton peter victoria South australia baseball Bob geren Victoria australia jason heyward jansen
"kartini" Discussed on The Long Run

The Long Run

06:36 min | 1 year ago

"kartini" Discussed on The Long Run

"To christopher and you have to say okay. We'll i'm i'm to this. I need to to deliver an even slightly larger amarnath but not that much larger plus a guy and you know that turns out to not be that different and so it has been it has been possible but it is. It is harder to get these zone piece to work correctly when you're delivering than people maybe originally anticipated But at this point there are several groups that are doing this successfully including us and we do think it is a great platform future because again. lp's are synthetic to manufacturer which means they will be much lower cost than other things. they're scalable. They are reducible unlike viruses. Right so you can potentially dose multiple times They are you know well. Tolerated transient in the systems. They go in create the editor. The editor edits in the whole thing washes out of your system. And it's gone within a few days you'll week and so that you know we. We love that profile The problem is they go to the liver So this is fact guide and so and so you know but but it turns out we were seeing some data like this our hands and then and then in others in the in the literature that if you change the formulation if you change the lipid if you make certain other recipe changes you can actually re target them towards other kinds of tissues and and so Guide their products was founded by James dahlman encore sago. Corey is actually now at beam James the professor down georgia tech and they basically build a beautiful platform that allows high throughput multiplex screening ellen. Peas in vivo. Basically does a whole bunch of lp's into an animal and then you can look at different tissues of interest and see which of the olympia recipes. Got me to this tissue versus app tissue and and then that becomes a new lead and you can kind of iterative from there back to that engineering principal and so we are now very hard at work. Pushing the envelope on where on peace can go well beyond the liver. Thinking about blood cells thing about sickle thing. That t. cells if you think about kartini analogy thinking about the brain muscle long. These are all of interest. And of course. In some of these experiments were screening all of them at the same time. So we're very bullish about the future. I think it is. It has become a new theme beam of how much we're investing now in the future of delivery as much as keeping investing in the future of of editing delivery is super important for going all the way back to the history of alagoas and basically all new modalities. It comes down to this and it's often not fully appreciate it in the early days but but so wait a minute. You saw this thing with guide that you liked and you know you got a lot of cash but you want to be careful in how you spend it and so you structure this deal in an unusual way as the development stage biotech company. You are you by that company in in your stock by march and the the investors in this little company accepted that. Yeah yeah so. So basically what guided done is they had made all this progress on You know the basic formulations in suddenly they were delivering not just as sirene spinout. Mrta's and into different tissues and so they were starting to say well. Wow so now. I really need to build downstream process development and editing. You know all these components that we just built and we simultaneously. Hip built all the things for the liver. We hadn't yet gone about building that platform to push the boundaries of what the technology can do beyond the liver and and so it was just a beautiful sort of match made in heaven in terms of the the sort of complementarity of our interests but they are very long term in their focus as our week And so we did structure this deal sort of using equity sort of focused on the future. Now that said it. It also has different. Flavors there's an upfront but there's also a lot of earn outs. That grow and grow as as the technology works. And i think that's that's obviously great and aligns incentives with them to to make big impact as we can. But i'd say it really comes back to just the synergy in the teams in having a really shared vision that you know we just somebody had to put together the kind of leading effort. That would marry the best of gene editing with the best of delivery specifically in this olympi- world at least So that we could under one roof create as many of the right medicines possible. And i think that's very much how it's worked out so far on onward and we're thrilled with the progress doubling down as we speak and are you bringing this and some other deliver technologies together in this big manufacturing investment in north carolina. And why. what's the strategy there. Why are you doing that. And take ke keeping that under your own rough and not going to contract manufacturers. Yeah well we're certainly contract manufacturers for now because is we go to the clinic that we're at and that's going very well But you know similarly to the delivery story where we have the novel. Editing were frustrated with the state of delivery and we say you know what we need to do this ourselves into it right and so that's what we've been building. The third leg of that stool is manufacturing in is still true that again because these are very complex medicines. There isn't mature crisper or gene editing or or self therapy manufacturing industry. It's coming a lot of people are investing in that And i think if you fast forward five or ten years when we might negative decision because there might be a lot more mature ecosystem out there but for now these are very specialized it takes a lot of know-how and to a certain extent that know how is proprietary and is some of the value of being like we have incredible people here who are working really hard to decide to figure out. How do you make these things at scale. How do you make them high quality you know. How do we turn this interesting technology into a new class of medicines and so ultimately we felt it would be much more efficient to again. Have that under one roof so we are building a facility. North carolina research triangle park. It's one hundred thousand square feet It is going to be. I think the biggest dedicated facility in the genetic industry and you know one of the things if you think about the diversity of the kinds of products. We're gonna make that. I was nervous about but it turns out we can manage is well. How many different kinds of things do we make. We need to make cells autologous cells allogeneic cells need to make 'em are a we need to make lipid particles guides but it turns out in modern manufacturing really can have these sort of flexible use spaces where you basically can convert them from one of the other fairly easily and so so it you know it just ultimately when we looked at it it was it was it was possible to build one facility that we do think even given the uncertainty about how our portfolio will evolve. can manufacture all the different things that we have to make and so we're growing that team down north carolina. We broke ground this year. Already that'll be operational by two thousand twenty three and then you know as much as we love..

James dahlman kartini alagoas christopher Corey georgia James North carolina research triang north carolina
"kartini" Discussed on Lore

Lore

04:20 min | 1 year ago

"kartini" Discussed on Lore

"Some people defy our expectations. We have assumptions about what we are capable of. And when someone rises above that bar where it left with the dilemma. Either we believe they are far more gifted than we could ever be or we soothe our minds with something less rational that they're exceptionalism comes from an outside source or musicians like giuseppi kartini and niccolo pagarini. There was a lot to come to grips with early brilliance extraordinary talents and performances. That may difficult. Things seem effortless. It's no wonder that in an era when nearly everything was somehow tied back to the christian church the people around them assumed some dark power was at work. The natural explanation turned out to be the most supernatural option as well that the devil this figure fascination and fear in almost everyone's mind at the time at somehow given them the cheat codes necessary to rise above us all and in the process these talented individuals became legends in their own rights. They said on that blurry line between real life and mythological status that very few people ever achieve so it's only natural on that stories about them persist. Even after so many centuries today pagarini violin serves as a reminder of that other worldly talent upon his death the instrument was not passed on to another human being because he feared letting someone else put their fingers on it instead. It was gifted to his home city of genoa. And it's been considered a national treasure ever since it's estimated to be insured for over thirty five million dollars. Pagarini is body though. Didn't get the same immediate respect. Thanks to all the stories that swirled around about his talents and the fact that he failed to make a final confession to a priest. From his deathbed the church of rome denied him a sacred burial. It seems that even though he had denied it in life the stories of the devil still controlled him in death for a while. The body was kept in the city of parma. It would take years before the pope would relent and allow the musician to be moved back to genoa but no burial was allowed. I don't fully understand how his body was stored and displayed but it seems that his rumoured deal with the devil had kept him from finally resting in peace for a good fifty years. Finally the city of parma allowed for a proper burial today you can visit his elaborate tomb and pay respects to a man who transformed music mesmerized audiences around europe and arguably became the first rockstar in music. History in two thousand nine. A new chapter was added to his story though. A locked box was put up for auction which contained a lack of the musicians. Hair a gift from pagarini himself to a friend and mirer back in eighteen thirty one and it allowed scientists to run a few tests. Now it was believed at the time. The pag anini had died due to burkey losses but the chemical tests revealed the different story one that shed new light on the final years of the musicians life. It seems that the hair contain massive amounts of something that should not have been there mercury historians now think they know the truth. All those many years of lovers had left pegeen battling syphilis a disease that was commonly treated with doses of mercury in many of the symptoms of mercury poisoning lineup with his final days gastrointestinal issues loss of.

giuseppi kartini niccolo pagarini Pagarini genoa parma church of rome pagarini mirer burkey europe pegeen syphilis
"kartini" Discussed on The Future of X

The Future of X

08:03 min | 1 year ago

"kartini" Discussed on The Future of X

"Agriculture has always been a part of the african american experience or the african experience in north america. Dr veronica womack is executive director of the rural studies institute at georgia college and state university in milledgeville georgia. She focuses on rural issues and works with african american farmers on agricultural policy when you think about the agricultural knowledge the innovation that came with the enslaved population to the states will to the colony at the time. Agriculture has has been the center of our experience. Here womack maxi's farmers as land stewards and producers but also as preservers of culture they are the creators of community that farmer is a culture keeper in that community. That farmer has heritage in history. That's vital to the vibrancy and survival of that community. The african american farmers that i have researched they continue to be the culture keepers the leaders of their communities The the land that they owned historically and today in some ways make them more independent in in in being able to be political leaders or or be Leaders within their community while my points to the contribution by african american farmers and to how land is tied to democracy land has always been the center of democratic processes here In in this country land was a symbol of freedom and self determination so african americans aspired and acquired land and land allows you to be more independent. Small farmers are often the heart of their communities. But how do we ensure that remains true when you support a farmer. Whether he's you know whether he or she they are black. White or whatever. You're supporting more than just that person in the farming capacity and that's important for people to recognize a small farmer a mid size farmer is connected to a community and they assist in the development and the sustainability of the community beyond just that far the role that that person is playing in the economic system as well as the democratic system is very important. Womack says we need better agricultural policy rules that explicitly protect small and medium sized farmers especially black farmers when you look at Agricultural policy particularly since the nineteen thirties the policy tint to support larger operations. So when you when you think about the resources that are available resources when we see resources we see services and programs that is formulated at the policy level. So if we're really interested in building strong small in mid sized farmers It's important for us to also look at agricultural policy and what we're focusing on in the policy that's critical because your policy. Is dan connected of course to the funding that will be available. That's connected to the research that will be performed To the education that will be provided around farming practices and and everything and so policy is at the core so what are some examples of regulations. That can help. The small farmers markets Opening up relationships between the farmer and schools. And what served at schools. All of that is being written into agricultural policy which is a plus for some small and mid sized farmers small farms need local and supportive relationships to survive. But what else. And we need more resources for people who may be interested in farming That's an important piece as well whether we doing. In agricultural policy to help support you know beginning farmers people who may be interested in in this profession but available to them. So what can we all do to ensure a future in which small farming communities are protected supported and respected susan. The kaku has one word of advice. Agro ecology ecology is the solution sustainable agricultural practices that think about the farmers think about climate think about biodiversity think about systems on food systems have existed for time immemorial this involves leading local farmers device farming solutions to suit their communities needs the future of thumbing should and must protect and celebrate small farmers and the future food must embrace What the movement on the continent at the moment is talking about which is very ecology and has been embraced across the world. As well kartini. Simone agrees that handing the wheel to small. Farmers is the way forward so they are very very effective and they can produce better and more diversified food that we need and so if we really want to sustain and to tackle problems with hunger and malnutrition are on the world is really a disney to turning the control and resources back to smallholder farmers and in the same time to enact agricultural policies that support that. This won't always be easy. But veronica hopes the future of farming will have more room for the difficult conversations to be had and for policy to address the inequities of the farming world through robust infrastructure and support. I'm hoping ten years in the in the future that will have more conversations about how agriculture is connected to our democratic principles so i think agricultural policy has to make a space for small mid size farmers to be able to to sustain themselves And i think having Building local food systems is a place that would be perfect for small and mid sized farmers. They they could provide you know fresh fruit vegetables. Those people that eat you know meat poultry or whatever but we've got to have agricultural policy to reflect the building of that infrastructure Small and mid sized farmers cannot compete with big agricultural production. And so we've got to be mindful that there's room at the table for all types of farmers making sure there is room at that table really depends upon all of us. It's up to you and me the consumers to decide where and how we want to support farmers those who depend on the land who work on it. Love it the choices you make. How and what you eat what you buy or who you buy from. These are decisions that impact farming and farmers today and.

Dr veronica womack rural studies institute georgia college and state univ womack maxi milledgeville north america Womack georgia kartini dan susan Simone veronica disney
"kartini" Discussed on The Future of X

The Future of X

07:44 min | 1 year ago

"kartini" Discussed on The Future of X

"In this season of the future of acts. We've talked about farming practices that he'll the soil dietary choices in the future of food and the role data will play in the farming practices of tomorrow in this final episode. We look at how big agriculture known as big ag will impact the farming industry and small farmers in particular. I what exactly is big. Agriculture big ag describes large-scale corporations involved in farming makers of tractors companies that sell seeds and large-scale producers. It is often used when pointing to the power imbalance between large-scale corporations and small farmers but before we get to that let's look at some advantages. Big ag brings to the table. Industrial farms produce more than small farmers. This makes sense. They have more tools more land and more helping hands a greater supply they bring to the economy feeds demand with ample supply. We as consumers enjoy lower prices at the grocery store. Large scale farms also drive innovation because they are always seeking to maximize productivity. This means better technology and faster adoption of it leading to better processes. But what are the costs to answer that. We look at landownership both in america and across the world as big ed grows the land available for small farmers obviously shrinks the expansions of big in the continent tanto grit conflicts over land of natural resources as was living space With the small farmers and indigenous communities kartini. Simone is based in indonesia. She works to support grain partners in asia. A nutritionist who has worked in rural development pertini is involved with the peasant and rural youth movements in indonesia as big egg expands it encroaches on these rural communities communities have cared for the land for centuries. That's why it it's better dangerous as we see The situations that small farmers as well as indigenous communities are facing because they are losing their lander the livelihood basically because of the competition with the big act. I think the biggest problem that we have is what Cutini has referred to which is a land grabs. Susan peacock was based in kepala. The capital of uganda. She works with grain partners across africa on trade policy. Issues like land grabs the african continent home to about thirty three million smallholder farmers so with the advent of big agriculture and with the advent of the industrial culture system we are seeing a loss of livelihoods for smallholder famines. The loss of livelihood is the tip of the iceberg and it comes with a host of other problems. We say that culture is the more of our economies. The land grabs have extenuating problems. That do come up once they start happening by losing their livelihoods people losing their homes losing diversity and we are losing the systems that we knew as continent as a result. We will eventually start seeing traditional foods. starting to disappear foods disappearing. Yes as big. Aga- applies pressure to small farms. The smaller operations are often forced to start growing cash crops instead of traditional ones cash crops are grown for their commercial value for their potential to bring big profits. Some cash crops include corn and wheat for cultural foods and ancestral histories. This shift can spell disaster. Susan mkaku again the cultural foods that we know starting to disappear is took about sugar cane talking about oil pound talking about vanilla about crops that we do not call food crops. So it's making whistle cash crops and commercializing agricultural system to the next that we didn't know or see before in both africa. Indonesia arising popular cash crop is poem which is used to make palm oil kartini. Simone in saudis asia were lift like in indonesia malaysia as well as the philippines. We are the world's prodigious producers of oil palm. You know indonesian militia combine produce over ninety percent eighty five ninety percent of oil palm in the world. So that puts a lot of pressure because oil palm is now using everything from food to non-food cosmetics and all different products that you can find when you go shopping. Small farmers feed the world. They produce more than half of the world's food but cash crops are not always meant for consumption as our guest mentioned. Cotton for example is a big cash crop so in some areas the adoption of cash crops by small farmers reduces the amount of food being grown locally. Susan nikola smallholder farmers do feed the world. Seventy percent of the food that is consumed around the world is planted by smallholder farmers if industrial agriculture coach only producing about thirty percent. That means that they're not producing food producing fuel so the shift to cash crops is creating a crisis for small farmer livelihoods and access to food. But what about the environment using moorland for agriculture must have a knock on effect in fact almost all of global deforestation. Eighty percent is linked to agricultural production. This is a problem. Forests are carbon sinks vital in the fight against global warming where more carbon is absorbed than released so thank forest soil and the ocean. Losing carbon sinks means more carbon dioxide in the atmosphere deforestation has transformed the amazon rainforest from carbon sink into a carbon source. It's carbon emissions come mostly from fires which are often lit to clear land for soy farming kartini simone. In our opinion. I think That this very problematic because if you let big act continues the speed that they are doing right now and the consequences is not just bad for the small farmers but it is bad for people in general And for the environment because we have to knowledge that we are now living in a time of crisis spokes climate crisis and the health crisis and big agriculture. Have been the culprit. Twenty twenty one has seen a decade high peak of fires in the amazon rainforest. These blazes are largely man-made they clear land for cattle or for agriculture. So this problem is getting worse. Not better big ag is pushing small farmers into practices that are bad for food crops the land and their own livelihoods but what impact does this all have on culture. A lot goes into an honest day's work at vital farms their purpose is to bring ethically produced food to the table and they believed that pastor raising animals is the most humane and sustainable way to achieve that. That's why vital farms partners with nearly two hundred family farms helping them to rotate their pastures. And do right by the land because helping the land helps the hints which helps the eggs. Which helps you. Vital.

indonesia Big ag pertini Cutini Susan peacock kepala Simone Susan mkaku asia ag famines africa Susan nikola uganda america kartini simone
Why You Should Care About Big Agriculture Getting Bigger

The Future of X

01:51 min | 1 year ago

Why You Should Care About Big Agriculture Getting Bigger

"What exactly is big. Agriculture big ag describes large-scale corporations involved in farming makers of tractors companies that sell seeds and large-scale producers. It is often used when pointing to the power imbalance between large-scale corporations and small farmers but before we get to that let's look at some advantages. Big ag brings to the table. Industrial farms produce more than small farmers. This makes sense. They have more tools more land and more helping hands a greater supply they bring to the economy feeds demand with ample supply. We as consumers enjoy lower prices at the grocery store. Large scale farms also drive innovation because they are always seeking to maximize productivity. This means better technology and faster adoption of it leading to better processes. But what are the costs to answer that. We look at landownership both in america and across the world as big ed grows the land available for small farmers obviously shrinks the expansions of big in the continent tanto grit conflicts over land of natural resources as was living space With the small farmers and indigenous communities kartini. Simone is based in indonesia. She works to support grain partners in asia. A nutritionist who has worked in rural development pertini is involved with the peasant and rural youth movements in indonesia as big egg expands it encroaches on these rural communities communities have cared for the land for centuries. That's why it it's better dangerous as we see The situations that small farmers as well as indigenous communities are facing because they are losing their lander the livelihood basically because of the competition with the big act.

Big Ag AG Pertini Indonesia Simone America Asia
"kartini" Discussed on Thrive Bites

Thrive Bites

02:28 min | 1 year ago

"kartini" Discussed on Thrive Bites

"I love the work that you're doing doctor call in with the correct formula and i told you earlier all the work that he put into getting all these different Healthcare practitioners health experts wellness experts. I'm to teach everyone. Because i could tell dr calling. You have such a passion to get the word out and it's helping a lot of people. So i just wanted to praise you and thank you for all the time and effort that you're that you put into the end that you that you're continuing to deal much. I really appreciate that and thank you for the work that you do. And you know You know i have a a another good friend You know that's also you know as dental. You know dental profession. You know surprisingly you would think this is almost you know almost common sense. She also says she's also a new win. She also says that you know. There's not that much nutrition that you guys receive in school as well and i thought that was just as surprising because medical professionals. We don't and you would think you guys were literally the gateway into you know the health into our body health. You don't sing at how everything is affected. So <hes> actually. That interview is actually my youtube channel. Is well on doctor. Connie win as well. So a guys thank you so much. Do you have any parting. Last words soccer. please check out on her company. Her website You know. I put on our her stuff again. You can find our ad. Dr anne kartini and happy hippo. Plant organics and You know thank you for the giveaway. That's very very generous of you and Yeah thank you so much for being on the show. Now thank you again to call in and everyone for joining us. I guess the howard great evening. Yes yes thank you so much. This ultra video k. and And we'll see you guys next week on next wednesday on at five pacific so take everyone. Please say lied to dr anne. okay bye bye. hey guys. That was another episode of thri bites. If you like that episode please describe and follow weekly for new episodes. And don't forget to rate us on apple podcasts.

Dr anne kartini happy hippo Connie youtube soccer dr anne howard apple
"kartini" Discussed on The Down and Dirty Show

The Down and Dirty Show

07:58 min | 1 year ago

"kartini" Discussed on The Down and Dirty Show

"Gonna threaten to killing on a regular basis won't happen. I got that. I got an that with mark to. I don't know if y'all remember but but we were tested. Do you remember chris. Probably we were testing and so we down there three days with ninety car and then we had two days with bush cars. Which what do you call them now. Expanded cars. Yeah something like that. But it bush cars were yet in daytona. So i was there a whole time. And i'm running data and i'm doing shock for all these cars doing all this. Well we get as like the last day. And i come over and i have a set of shocks because the nine car was out running the sixty car. So burton was out. Running marks bush car so mark of course is beside himself. So i can bring you shocks over. And i go to set on a bench and mark turns around and grammy me slings amount of a handy those on the bench and it caught me off guard for a second and i went. I was fixing to grab mark and i stopped turnaround in a garage. Now fight madame. Been there five days. And i come around the corner. I run into jack. Grab jack and i stayed you go but bubba bubba up that. I'm going to win. this is all done. I'm whooping right here in his garage area in so about thirty minutes later here come mark. Sorry about that out there yet crazy times. You don't remember that. Chris i wasn't there. How did they. The seeks jumper star of that deal with burton and no-one out running commute hot user. Remember this burton now. We were mark but they started that deal in a communist thing steaming in looking at or you're in the train. I'm looking in the garage. Bulls off running income esteem and thing son got about right and i stand there looking after steve. He goes what i said. Look at the degree of cardboard still in front of he went. I got to do this. I got to tell me because you know rabbi wrong when everybody moved because you feel but it wasn't that way really but some people you got urban this very my motivation i so he went and told him about the next time we went out for god let the caption close in. Remember it's amazing. How how times have changed. Because that particular program i got jack and And we went to got more than in He had his reasons and But i won't get into all that about doing that with but anyway he The team the team. It was restoration. Okay but there was no no help at all. Now you've got you got you got bush teams cup teams all those cars and they're all feeding all this information. Just think if we had had been able to to capitol thing together and cooperate with each other you know and like i said i'm not gonna name names and things. Everybody knows no oppo program. But i was proud of of that rash program. Probably jack was probably the best guy work with car owner. Let me do whatever i wanted to do. And we don't think we ever had a harsh word and now wow was there. Why was knocked cooperation between the tapes. Was that a directive from somebody or was that just the way one of the proof to mark that he could do it because there's a bunch of turmoil going on up there. It was a period of you had so many one car teams and it was right when the transition will start to be multi car teams exactly and if the world was still round. We'd have forty one car. Teams'll that's tha- that's when it was fun. The multi car teams met difficult. Just because there was no testing aussie talked about. We did it with thirty five people. We raise on sunday drive if we drove to the racetrack and flew home. If we flew we drove or back and forth on the other crew worked in a shop and we got home on sunday. You'll one day. Debrief t tested tuesday wednesday through that back down picnic national league right or wrong. Now these guys got a cruise get days off and the crew as they got they got. They got three teams. They got a team that works on race cars in the shop. They got a team that travels and they got a team. That does the pitstops. That's three separate teams. And i remember if you're doing pitstop thanksgiving day and christmas eve alley wall williams. The man count for for the teams were started out. I think like ten or twelve and then we got. I think the before i left in two thousand one. The count was fifteen per per per team. So now okay. Yeah but if you want to go back to the this if you want to go back to the the competition between it it went on way before that remember we went to daytona test. We had jr twenty and we run fast. Look at it. You see them laughing. Let's put back onto the net car as we wrap. Jr twenty and we brought that thing home because it was all prominent and they painted blue and it had a six on when we went back to daytona more martin mark call. The shots would be able to cars. When i came back. When charlotte is both primer. A thirty fifty in his car take went out running a lot slower. He goes go get mark. Put him in there in. Buddy fossils usually. He's half a second rags. See goes because i can't reach the pedal good and i'll just shake it down. Didn't change tires and here on thirty forty five becoming he goes jerry. I said look. You're home to sing red-white-blue you change your shock. And i said on the pope. Okay you would have terminal market. Yeah mark. did that with wally. Wally come back to me. I said whoa is worth. Secondly i mean he's he's a race car he knew what he morning knows. How large no matter duty came came along. He came a long time with russia. Walsh russia didn't want to kartini. Or are bobby their mentality. They wanted to keep. They want to keep their what they did on the cars because marcus sharp on racing or he could he could. He could help you and listen to him. He knew a new things to to do the race car. Rusty russia was hands on with me. You know that was well. I've said race car drivers never been team players. They grew up going to the racetrack with go karts race cars and it's usually a family operation and that was their team and it was all about them. Everything was focused on them and and even before the head team drivers it was about them. Because you know at the end of the day they they were their own team. They're independent contractor and Boy when you when you got out of the era where they rode with you to the race stratton into van in the car and then the motorhome thing came along and then of course the jets and the helicopters and all that all of a sudden they were an independent contractor and they was they. Were there only team.

bush burton bubba bubba daytona jack mark grammy Bulls chris rabbi martin mark Chris steve national league kartini russia marcus sharp williams charlotte Buddy
"kartini" Discussed on DV Radio

DV Radio

05:42 min | 1 year ago

"kartini" Discussed on DV Radio

"Back last fall or in the fall of twenty thousand nine when this started when we did the roundtable i had somebody who owned a hotel on the dog. Page arguing that we should have to fill out same form that they were proposing department of transportation for flying to rent a hotel room. And i said absolutely not because the whole point of the americans with disabilities act is that i am treated equally regardless of what i use to assist me with my disability. Right that's the whole point. The whole point is if you can walk into a grocery store and nobody stops you to cards you then. I should be able to walk into a grocery store and nobody stopped me to kartini or right fill out a form attesting to the fact that my dog is trained. My dog's behavior speaks for itself. I can't tell you to this day yesterday morning at the grocery store a lady said i can't believe how well behaved. He is and every time. I hear that my answers the sustain. He wouldn't be much of a service dog if he wasn't her. It's part of his job it they don't understand it. He's not your normal household dog. He's not a pet. Monkey is learning that. She's not going to be a pet day working professional. I was just in our shit inventory control department today fixing a computer in its woman kept looking at scout and trying to to get his attention and he was watching that door and she kept talking to him and he would look at her and look back at the door in his job is to watch that door while computer and she's just like he will not look at me he will not pay attention to me. I'm like his job is not to be your buddy. His job is to watch that door now. leave him alive. If he's not your buddy he's not your pet the up. His job is to protect me in to watch what i can't hear.

last fall today americans with disabilities ac kartini yesterday morning twenty thousand nine this day
"kartini" Discussed on WBZ NewsRadio 1030

WBZ NewsRadio 1030

03:08 min | 2 years ago

"kartini" Discussed on WBZ NewsRadio 1030

"And expected part of getting the vaccine, especially the second dose, and these symptoms mean that your immune system is revving up and the vaccine is actually working. The CDC says roughly a million doses were getting administered so far this week, and though there is a downward trend in cases, health officials say overall numbers of Kobe cases are still too high legislation on Beacon Hill that would make it illegal to encourage someone to commit suicide. It comes after the Michelle Carter suicide by text case we can pour from WBC's Jim McKay. It's something that's been in the works for quite some time. If it passes on Beacon Hill, it would be known as Conrad's law we're doing is we're making it criminal to core someone into suicide and over Denver. Craddick, State senator, Very fine Gold, the sponsor of this bill, he worked on it with the family of Conrad Roy, the 18 year old from Plainville, who committed suicide back in 2014. The bill would make someone criminally liable up to five years in prison. If they willingly course someone they knew had mental health struggles. He worked on the bill with Conrad's mother, Conrad's mother land and the rest their family an amazing amount of credit for taking this tragedy and trying to do some good covert 19 put the brakes on this bill during the Last legislative session, Senator Feingold hoping this time around it moves forward. Jim McKay WBZ Boston's news radio. A week after Inauguration Day, the Department of Homeland Security, issuing an advisory about the possibility of further violence across the country. Acting Homeland Security Secretary issued this bulletin, which says there is a heightened threat environment across the U. S. That's likely to persist for weeks. There is no information on specific plot, but the bulletin says intelligence and law enforcement Remain concerned about individuals angry about the election outcome, fueled by false narratives and emboldened by the breach of the capital of CBS is Candy McCormick, the state appeals court ruling against the bicycle issue. It sued after he got into an accident on the North Shore because of a dog attack. BBC's Carl Stevens explains in the summer of 2015 Victor crew, Tini was riding his bicycle in swamps get with his dog on a leash, but the dog was attacked by another dog, a pitbull, causing him to crash. He was hurt in the crash and sued not only the dog owner but the landlord who rented to the dog owner, arguing the landlord should have known there was a dangerous dog on his property. But the state appeals court has ruled the landlord has no liability in this case. Kartini did reach a settlement with the dog owner. But as far as the lawsuit against the landlord is concerned, he was barking up the wrong tree. Carl Stevens, WBC Boston's news radio, how spilling what island is allowing for injured police dogs to get life saving treatment in an ambulance. The addition to the animal care law was introduced last year by representative David Bennett. The bill, however, expired in last year's legislative session. So Bennett reintroduced the bill yesterday. Would allow e m t workers to perform mouth to snout resuscitation Give the dog oxygen stabilized, Broken bones and more bill frees E M T s from being liable for a vet bill or for mistakes. Treating the dog. Ah Los Angeles City Councilman is going viral on social media. After a new embarrassing moment. Kevin De Leon was leading the council in the Pledge of Allegiance when he forgot the words and Stopped pleasure allegiance to the.

Conrad Roy Senator Feingold Jim McKay Beacon Hill Carl Stevens Boston Kevin De Leon Department of Homeland Securit Michelle Carter David Bennett CDC Kartini senator Kobe Los Angeles BBC Secretary
"kartini" Discussed on WBZ NewsRadio 1030

WBZ NewsRadio 1030

01:49 min | 2 years ago

"kartini" Discussed on WBZ NewsRadio 1030

"It's 1 56. The state appeals court has ruled against a bicycle. A bicyclist who sued After he got into an accident on the North Shore because of a dog attack WBC's Carl Stevens with more in the summer of 2015, Victor Krotine, he was riding his bicycle in swamps get with his dog on a leash, but the dog was attacked by another dog, a pitbull, causing him to crash. He was hurt in the crash and sued not only the dog owner but the landlord who rented to the dog owner Arguing the landlord should have known there was a dangerous dog on his property. But the state appeals court has ruled the landlord has no liability. In this case. Kartini did reach a settlement with the dog owner. But as far as the lawsuit against the landlord is concerned, he was barking up the wrong tree. Carl Steven stop BBC Boston's news radio. Well, this story is for the dogs. Ah House bill in Rhode Island would allow injured police dogs to get life saving treatment in an ambulance. The addition to the animal, Caroline was introduced by representative David Bennett. It would allow e M T workers to perform mouth to snout recitation resuscitation. Also, the dog would get oxygen they would stabilize broken bones and more just like people. And the bill frees E M. T s from being liable for a vet bill And you know, if you're a pet owner, those could be Pretty high or for any mistakes in treating the dog. It's 1, 57 and We're watching some snow tonight. We've got a lot going on coming up in two o'clock. Then Parker will be joining you talking about the registration now underway for older Massachusetts residents to try to get their covert 19 vaccine. They're running into some snacks. Then we'll tell you all about that at two o'clock..

Victor Krotine Kartini Carl Stevens Carl Steven North Shore Boston Parker Massachusetts Rhode Island BBC David Bennett Caroline representative e M T E M. T
"kartini" Discussed on Mayo Clinic Q&A

Mayo Clinic Q&A

05:51 min | 2 years ago

"kartini" Discussed on Mayo Clinic Q&A

"Chemotherapy the mainstay of treatment fully kimia or the other treatments that you use as well. Yeah it is my my hope in my career that we stop giving chemotherapy one day and But it's still essential for leukemia especially in younger dogs. Chronic leukemia is almost completely moved away from therapy. We learned a little over twenty years ago. That for chronic myeloid leukemia. Cml that there's a targeted therapy we can use all patients with c. m. l. We'll have an abnormal chromosome. Did they acquire. They're not born with it. We call it the philadelphia chromosome because it was discovered in philadelphia. And there's a their medications pills that can actually specifically target that philadelphia chromosome to put people into long term remissions and we've learned for cml in the nineteen nineties. The average person lived for years in two thousand and twenty. Somebody was c. L. has the same long term survival as another person their age. Who doesn't have stand now as long as they're under therapy and under observation so that's been also remarkable success story for c. l. l. which is a little more common than adults. We used to give chemotherapy. We learned in some random studies published in the last two three years one of which was published by one of our colleagues teach. Nfl when he was at mayo clinic. The targeted oral therapies which are much easier to take are more effective than chemotherapy. Give better long term survival. So in the chronic leukemia is it's less and less common for us to talk about human therapy and acute leukemia. We still rely on chemotherapy to get remissions. We're looking at antibody. Based treatments we're looking at immune based treatments. We have some solid leads there and we can do bone marrow. Transplants in certain situations Secure them. But we're looking for more targeted treatments. And i hope that they will come in my career. When i don't have to use the word of chemotherapy just extend that thought for one second. I'm sorry to jump in. Lee's i'd say the problem with that works and so it's a scary concept and people have a notion of mental notion from tv movies or from somebody in their family from you know ten or twenty years ago. How difficult it is. But we're better giving it we get people through it. Were very good at the side effects. Now and the only reason to do it because it works and when the day comes we have something better. Will you know we. We will rush to move to that but but right now they work and so we use them so given the different forms of treatment that either currently available on the horizon. What does mayo clinic doing. In terms of clinical trials. That patients may be able to access. No i think that's really critical question. You know to to to get better treatments. We need clinical trials and we are believers. And then we're innovators and at the front of the field and yeah My colleague mark lasalle. Who's acute leukemia. Dr rochester leaves one of the national study groups and killed leukemia We've had leadership in. Chronic leukemia is as well We are looking at multiple avenues for patients who are newly diagnosed and also for those who've been through treatment and didn't go into remission or relapse for that where we're using innovative sometimes chemotherapy but more likely innovative targeted treatments or innovative. Immune treatments so we have a series of clinical trials depending on the exact situation That we're looking to try to get better outcomes for patients trying to get more emissions second time around or even upfront and your people more often and so. That's that's really a critical Avenue for us one of the great innovations in acute leukemia so far applied only children but being developed in adults or children in adolescence. I'll say is the use of something called kartini therapy. And i'm not sure if you've heard of that but it stands for america. Antigen receptor t..

ten mark lasalle rochester one second two thousand twenty years ago Lee america twenty over twenty years ago second time one one day myeloid leukemia nineteen nineties kartini leukemia years philadelphia
Tuning the CAR T

Sounds of Science

04:54 min | 2 years ago

Tuning the CAR T

"I've always liked the word camera. It's one of those difficult to pronounce words that has many exciting definitions. Is it an ancient Greek monster cobbled together from several fearsome creatures? Is it an illusory pipe dream a wispy Mirage on the horizon or something from the island of Dr? Moreau each instance features heavily in some of my favorite fantasy books as a kid. Today is part of the subject of our podcast kyw Merrick Antigen Receptor T. cells better known as carty cells. You're in the real world. These Americ- antigens are much better than fantasy. They life changing therapies here to speak about these wondrous cells is Sunday. Halt! Group leader Biology for Charles Rivers Light. Incite welcome Sanni. Hi Mary thank you for having me. Thank you for being here. So I some background. Could you explain what these engineered cells are before? We get into how they're used? How long have they been around? Absolutely so t cells are cells near immune system that played important role in eliminating foreign. Foreign invaders they do so through target specific binding using receptors on their surface who owns a t.? Cell binds at it triggers the cascade which can lead to killing of the infected cells, commerical Antigen, receptor, or car you mentioned can be designed in a lap to bind only one specific target. If you add these engineers car onto a T. Cell, you generate new T. cell, which has the ability to bind and kill specific cells which express that target that you designed your car for okay defers, clinical trials into RT sells for a really reported, trying to buy two thousand and five and currently being. Over five hundred trials ongoing said this is a massive increase and really shows potential that these Arabs have. Currently there to fully APPREC- cartoon south at on the market, which I was approved in two thousand, seventeen so Howard, these sells used in cancer treatments so cancer, except it's very different expression profiles than normal cells. If you can find a target on a cancer cell, which is not present on healthy cells, you can design a car against his target by then treating these cancer patients with the cartel cells designed against cancer specific target, the Kartini cells will kill the cancer cells, but touch any healthy cells. This would be a major improvement over current chemotherapies or also healthy cells are killed. It also makes cancer treatment a lot more personalized for each patient. Unfortunately, it's not quite as simple as making it saint, and these therapies all that they have major potential have some serious challenges so basically what you're saying is you can design. Like a normal human immune cell, but give it a a sort of a key that will fit only into the specific cancers lock exactly that's very wave describing it, so this has been going on for a while as you said, but you mentioned that there's sort of a a new up start, which is t cell receptor therapy? Can you tell me about that? And why? It might be a better alternative? He absolutely so I'm not entirely sure of could call it a better alternative, but they're definitely turn it, and they've got some pros and cons same, said the car t-cells, so t cell receptor therapies are t, crt cells are. Are, in many ways similar to cells where you do engineer receptor onto a T. cell in this case, you just engineer a tea CR onto it instead of a car, the advantages, but also some challenges of t cells is that they bind through h receptor on the one hand. This means that you can actually select from much larger set of targets, which increases the chances that you can find that one target that's only expressed on cancer cells, but not on healthy cells, and on the other hand it also limits ED patient population because people have very different lots of different types at an it makes a safety testing in animals. Very close to impossible. You mentioned earlier. That safety can be a real concern. We can talk about I about some of the reasons. Safety needs to be so so thorough I understand that these can have some really serious side effects. So can you talk about those little bit? He yes, absolutely so as she mentioned your metaphor if she give these cells, the receptor, which could be key. Key and then it only fits in the lack of a cancer cell. You need to make sure that the key doesn't work on any other locks, and so if the target expressed on the cancer cell that you've designed to St CRT, sell or your car, T. Cell Four. You need to make sure that that target is not expressed on any other healthy tissue if Any of your organs express that same target, the Tesol will bind kill also your healthy cells near healthy organs, and that's something yet. You very clearly want to avoid.

Engineer Mary Moreau Carty Charles Rivers Light RT Group Leader Howard
Tuning the CAR T

Sounds of Science

04:00 min | 2 years ago

Tuning the CAR T

"I've always liked the word camera. It's one of those difficult to pronounce words that has many exciting definitions. Is it an ancient Greek monster cobbled together from several fearsome creatures? Is it an illusory pipe dream a wispy Mirage on the horizon or something from the island of Dr? Moreau each instance features heavily in some of my favorite fantasy books as a kid. Today is part of the subject of our podcast kyw Merrick Antigen Receptor T. cells better known as carty cells. You're in the real world. These Americ- antigens are much better than fantasy. They life changing therapies here to speak about these wondrous cells is Sunday. Halt! Group leader Biology for Charles Rivers Light. Incite welcome Sanni. Hi Mary thank you for having me. Thank you for being here. So I some background. Could you explain what these engineered cells are before? We get into how they're used? How long have they been around? Absolutely so t cells are cells near immune system that played important role in eliminating foreign. Foreign invaders they do so through target specific binding using receptors on their surface who owns a t.? Cell binds at it triggers the cascade which can lead to killing of the infected cells, commerical Antigen, receptor, or car you mentioned can be designed in a lap to bind only one specific target. If you add these engineers car onto a T. Cell, you generate new T. cell, which has the ability to bind and kill specific cells which express that target that you designed your car for okay defers, clinical trials into RT sells for a really reported, trying to buy two thousand and five and currently being. Over five hundred trials ongoing said this is a massive increase and really shows potential that these Arabs have. Currently there to fully APPREC- cartoon south at on the market, which I was approved in two thousand, seventeen so Howard, these sells used in cancer treatments so cancer, except it's very different expression profiles than normal cells. If you can find a target on a cancer cell, which is not present on healthy cells, you can design a car against his target by then treating these cancer patients with the cartel cells designed against cancer specific target, the Kartini cells will kill the cancer cells, but touch any healthy cells. This would be a major improvement over current chemotherapies or also healthy cells are killed. It also makes cancer treatment a lot more personalized for each patient. Unfortunately, it's not quite as simple as making it saint, and these therapies all that they have major potential have some serious challenges so basically what you're saying is you can design. Like a normal human immune cell, but give it a a sort of a key that will fit only into the specific cancers lock exactly that's very wave describing it, so this has been going on for a while as you said, but you mentioned that there's sort of a a new up start, which is t cell receptor therapy? Can you tell me about that? And why? It might be a better alternative? He absolutely so I'm not entirely sure of could call it a better alternative, but they're definitely turn it, and they've got some pros and cons same, said the car t-cells, so t cell receptor therapies are t, crt cells are. Are, in many ways similar to cells where you do engineer receptor onto a T. cell in this case, you just engineer a tea CR onto it instead of a car, the advantages, but also some challenges of t cells is that they bind through h receptor on the one hand. This means that you can actually select from much larger set of targets, which increases the chances that you can find that one target that's only expressed on cancer cells, but not on healthy cells, and on the other hand it also limits ED patient population because people have very different lots of different types at an it makes a safety testing in animals. Very close to impossible.

Engineer Mary Carty Moreau Charles Rivers Light RT Group Leader Howard
Firefighter killed as natural gas blast rocks Wisconsin city

Steve Cochran

03:16 min | 4 years ago

Firefighter killed as natural gas blast rocks Wisconsin city

"And tune in and if you get too close to your radio you might sense a little bit of cherry slurpy on my breath i don't know that will ever be the same steve's steve good morning everyone seventy five degrees on our way to maybe eighty eight today one firefighter has died another has been critically injured in a natural gas explosion and fire that level leveled several buildings in southern wisconsin in the community of sun prairie thirty say that at least six firefighters were injured along with some civilians when a private contractor struck a natural gas main about six thirty yesterday laurie oakley lives there she talked about the downtown area where it happened at around seven o'clock last night just done so much work the city to maintain it and approve the structures and add more you know more restaurants for people to come downtown and now we have just devastation down here forty cents on prairie say the critically injured firefighter is improving this morning grief counselors have been sent to offer assistance to chicago police officers at the district stationed on the city's south side a veteran officer collapsed and died there yesterday on sunday an officer committed suicide in the station's parking lot a veteran cook county judge is facing a misdemeanor gun charge sarah sheriff's deputies saw him drop a pistol in criminal court house at twenty six cow wgn's pam jones with more courthouse surveillance video shows judge joseph claps walking in the lobby he has a jacket folded over his arm a handgun drops to the floor from underneath jacket representative from cook county sheriff tom dart's office tells the trip it's believed the gun was loaded judge claps has a ford card and concealed carry license but weapons are banned from the courthouse even for concealed carry holders pam jones wgn news president trump here's at nato headquarters in brussels for the first of two days of summit talks he began by lecture shering nato allies this morning and targeting germany specifically saying germany in his words is totally controlled by russia secretary general says he agrees with president trump to a point that nato allies should contribute more to the alliance in terms of defense spending but he also defended nato saying there is strength in unity it is in the interest of europe earning interest of states i ain't gonna stay together the color of bubble gum flamingos and cotton candy bright pink is the world's oldest color according to a recent study researchers discovered the ancient pink fig pigments in one point one billion years old rock deep rocks deep beneath the sahara desert making them the oldest colors in the geological record the bright pink colors are more than five hundred million years older than the next oldest known pigments and were produced by ancient ocean organisms now wgn sports here's dave bennett well for the second straight night a pitch dole between the cubs and giants in san francisco this time the cubs came out on top a score the games only two runs in the seventh inning one on an error what victor kartini devil and the cubs blanked the giants tuesday for the ninth win in eleven games jose cantata six innings at three hip ball followed by carl edwards junior and then justin wilson and then steve see shack more good news for the cavs kris bryant expected.

Five Hundred Million Years One Billion Years Two Days