5 Burst results for "Joshua Schiffman"

"joshua schiffman" Discussed on 600 WREC

600 WREC

11:27 min | 1 year ago

"joshua schiffman" Discussed on 600 WREC

"Sought significantly better treatments. Doctors study cancer is vulnerability. So they can attack cancer when it happens. And they try to understand why cancer happens in the first place. So someday, they can prevent it. Normally cells will divide when they need to and then stopped growing in the case of cancer. What happens is the cells continue to divide over and over and over again. And they've lost the ability to stop growing. That's Dr Joshua Schiffman, professor of pediatrics at the university of Utah and an investigator at the Huntsman Cancer Institute there and eventually they become so large that they take over northern in the body. Sometimes they spread to different locations in the body. And if left untreated, they'll go onto almost certainly kill the patient over the course of a lifetime. About forty percent of people will develop cancer. But what many people don't realize is that the first steps toward cancer are happening in our bodies all the time, but they don't get far everyday just walking down the street. We are getting hundreds of thousands if not millions of mutations, but our body is designed to actually eliminate those. So that we don't go on to develop cancer. Although even so half of all men in a third of all women will develop cancer throughout their lifetime. And as we get older our ability to fix those mutations in the accumulation of those mutations that sneak by DNA repair system begins to grow, and if you live long enough there, unfortunately is a pretty good chance that you may develop cancer, those are dying in your body all the time. So your body needs to replace those dead cells. So, you know, every time a cell dies. It's replaced more or less with another healthy cell. And sometimes that process goes awry, and sell it's not. Quite cancer all the way, but it's pre-cancerous and your body's immune system, for example, might recognize that pre-cancerous sell as not being quite right, and sort of mountaineering response against it and kill it. Dr Vincent Lynch is assistant professor of human genetics and organism biology and anatomy at the university of Chicago. Sometimes that process doesn't happen in those cells escape, for example, that immune surveillance, and then they start to mutate in ways that makes it much harder for your body to recognize them as foreign and that allows them to escape the normal mechanisms that keep uncontrolled cell proliferation in check why the immune system fails to detect those mutations is the subject of a great deal of research as Shiffman says age may often have something to do with it. But obviously sometimes it doesn't why would children get cancer. Because this is really an interesting question. Right. Why would someone so young developed cancer at such an early age? They haven't lived long enough to accumulate all those mutations that happens in time in. Of the environmental exposure. So we believe that there's a strong genetic component that contributes to the risk of childhood cancer. And we're trying to understand exactly what that component. If she hasn't been says a few children have genetically weakened immune system, their DNA repair mechanisms are themselves mutated. So their rate of developing cancer is very high when cancer develops in any of us a similar failure has occurred. There are over twenty two thousand different genes that we have as humans in each gene has a very specific job. And if those genes get altered changed or mutated then the instructions that those genes code no longer can be read in that Jean can't performance job. And some of these genes their job really is only to protect us from cancer. And if you start losing those genes, then you've lost your protection for cancer. Lynch and Shiffman say one of the principal cancer protection g. Genes in the body is called p fifty three or p fifty three. It's so important that some people call it the guardian of the genome when a cell starts to go awry when a cell starts to have a mutation or turn into a pre-cancer. So that there's a spelling mistake and its DNA p fifty three shows up on the scene and helps to fix it. It's almost like a big spell checker. So basically, it's hanging out in your cell all the time doing nothing, and then if your cell experiences DNA damage, it does two things it starts to stop watch which gives the cell time to repair the damage so normally cells are dividing and it stops the cell from dividing until the damage is repaired. The thing is it's counting is not giving the cell an infinite amount of time to repair the damage if it takes too long to repair the damage it causes the Celtic kill itself, and sort of the biological rationale. There is if there's only a little bit of damage, your Celcom probably repair that without there being much of a side effect. But if there's a lot of damage chances are the cell is going to be able to repair all of that damage very faithful. And so it can repair some of the damage correctly. But some of the damage may escape that repair. And if that's the case it's better to just kill the cell. But when those cancer protection jeans or the tumor suppressor genes when they get mutated or they don't work properly anymore. Then there's nothing protecting us from developing cancer. The cells have lost their first line of defense. Some animals, however, have a first line of defense that seems to never fail for example, only about three percent of elephants ever, get cancer and Shiffman and Lynch say that flies in the face of what you'd expect of a large animal elephants are one hundred times the size of people that means they have a hundred times as many cells, which is actually if you think about it a hundred times as many chances for randomly developing those mutations not only that elephants live quite a long time. They live fifty sixty seventy years that many cells divide. Decade after decade after decade, just by chance alone. All elephants should actually be dropping dead of cancer. But they almost never do. There's no relation between body size and the incidents of developing cancer and on one level. The answer is really simple. These big things have just of all ways to reduce their cancer risk and on another level. The answer is really complicated. It's well. Okay. How are they doing that? How they're doing. That has been the subject of both Shiffman and Lynch's research examining the elephant genome. They're separate studies in the journal of the American Medical Association and the journal he life show that the answer is pretty clear instead of two copies of that Fifty-three Jean. We were talking about all humans have two copies one from their mother one from their father instead of two copies to protect them from cancer elephants had forty copies so twenty times as many copies as people that could create an elephants a. Theoretically, nearly failsafe cancer surveillance system. One way that an organism could increase its cancer resistance is just have lots of extra copies of p fifty three. So if one of them becomes mutated and nonfunctional, there's backup redundant copies. I can take over the role of the normal copy. Lynch found extra p fifty three genes in skin cells of both Asian and African elephants from the San Diego zoo Shiffman took a similar route seeking elephant blood cells. I found myself at the local Utah, HOGAN zoo whenever blood was being drawn again for other reasons, we were able to get some of it to our lab and studying and sure enough what we learned was that these extra copies of p fifty three indeed seem to be contributing to the ability of the elephants out to rapidly remove any type of pre cancer that was occurring. She hasn't been put the elephants cells into a lab dish, and expose them to radiation. And chemotherapy prompt. DNA damage to make them pre-cancerous. And he did the same thing with human cells to compare how they worked and what we found was that always the elephants sales were much more sensitive to the DNA damage. They were able to eliminate those cells with the cancer and much more quickly. And we were able to demonstrate that the way they were doing that was they were activating this P fifty three system of cell death. And so the elephants we were able to say had evolved a much more robust system for eliminating cells that have DNA damage can go on to form cancer. And this actually makes a lot of sense. If you think about it from the perspective of elephant, they're so large so many cells they can't afford to get cancer because they would go extinct that research is going one step further now with a goal of turning elephant p fifty three into something that can help people. We're trying. To figure out is there a way that we could actually somehow deliver this elephant p fifty three to actually give to our patients to maybe treat or perhaps even one day prevent cancer. And maybe in the future who knows make a medicine that could be given to people. She hasn't been steam has exposed seven different kinds of human cancer cells to elephant p fifty three with dramatic results. The cancer cells shrivel and explode killed by the elephant p fifty three similar to if you put human p fifty three into a cancer cell where able to actually use laboratory techniques to put the elephant p fifty three into it and observe the effects in some of these cancer cells, and we're able to show that some of these cancer cells in a dish are actually like you said exploding undergoing a Potosi they actually shrivel up and go into that debt psych. Title, and then just basically turned into a little small pieces that finally disappear. So it's really very early, but it's still very encouraging. But if extra p fifty three is so protective Lynch asks why are elephants about the only animals that have it. If this was such a great answer to solving the cancer problem. Why haven't all the other animals that we looked at? And we looked at maybe a hundred of them. Why don't they have extra copies of p fifty three? And the fact that they don't suggest that there might be some trade off that goes along with having extra copies of p fifty three other studies that engineered extra p fifty three into mice show that they age quickly. At least win the p fifty three is turned on all the time. They didn't get cancer. But they quickly got old in other ways that doesn't happen if my syringe neared, so they're p fifty three is active only in the presence of DNA damage, but genetically engineering everyone's immune system doesn't seem to be a likely. Strategy at least not in the short run. She has been says the more likely route will be to try to create a medicine using elephant DNA, can we actually figure out a way to take this elephant p fifty three and make medicine out of it to help our patients to help treat cancer that they have or maybe one day in the way future to even prevent cancer. Just like the elephants don't have cancer. We want to figure out a way. How can we make it? So that people don't have to get cancer. Again. She is hopeful, but he's also cautious. This is not a cure for cancer. He says.

cancer DNA damage Dr Vincent Lynch Huntsman Cancer Institute Shiffman Jean university of Utah Celcom Dr Joshua Schiffman San Diego zoo Shiffman professor of pediatrics Potosi university of Chicago investigator chemotherapy journal of the American Medica Utah assistant professor
"joshua schiffman" Discussed on 600 WREC

600 WREC

11:13 min | 1 year ago

"joshua schiffman" Discussed on 600 WREC

"The Potomac river boat company whose to the war Georgetown waterfront national harbor and Alexandria, enjoying breathtaking views of the city and zero traffic votes depart every twenty five minutes from early morning to late night get out of the car and onto the water with atomic riverboat company. Connecting all waterfronts running through December thirty first learn more at Potomac river boat, co dot com answer happens in the first place. So someday, they can prevent it. Normally cells will divide when they need to. And then stop growing in the case of cancer, though, what happens is the cells continue to divide over and over and over again. And they've lost the ability to stop growing. That's Dr Joshua Schiffman, professor of pediatrics at the university of Utah and an investigator at the Huntsman Cancer Institute there in eventually they become so large that they take over Norbert in the body. Sometimes they spread to different locations in the body. Eighty and if left untreated, they'll go onto almost certainly kill the patient over the course of a lifetime about forty percent of people will develop cancer. But what many people don't realize is that the first steps toward cancer are happening in our bodies all the time, but they don't get far everyday just walking down the street. We're getting hundreds of thousands if not millions of mutations, but our body is designed to actually eliminate those. So that we don't go on to develop cancer. Although even so half of all men in a third of all women will develop cancer throughout their lifetime. And as we get older our ability to fix those mutations in the accumulation of those mutations that sneak by DNA repair system begins to grow, and if you live long enough there, unfortunately is a pretty good chance that you may develop cancer, those are dying in your body all the time. So your body needs to replace those dead cells. So, you know, every time a cell dies. Replaced more or less with another healthy cell. And sometimes that process goes awry, and sell it's not quite cancer all the way, but it's pre-cancerous and your body's immune system, for example, might recognize that pre-cancerous cell as not being quite right and sort of Mount Zion response against it and kill it. Dr Vincent Lynch is assistant professor of human genetics and organism biology and anatomy at the university of Chicago. Sometimes that process doesn't happen in those cells escape, for example, that immune surveillance, and then they start to mutate in ways that makes it much harder for your body to recognize them as foreign and that allows them to escape the normal mechanisms that keep uncontrolled cell peration check, why the immune system fails to detect those mutations is the subject of a great deal of research as Shiffman says age may often have something to do with it. But obviously sometimes it doesn't why would children get cancer. Because this is really an interesting question. Right. Why would someone so young developed cancer? Such an early age. They haven't lived long enough to accumulate all those mutations that happens in time in all the environmental exposure. So we believe that there's a strong genetic component that contributes to the risk of childhood cancer. And we're trying to understand exactly what that component. If she has been says a few children have genetically weakened immune system, their DNA repair mechanisms are themselves mutated. So their rate of developing cancer is very high when cancer develops in any of us, a similar failure has occurred there over twenty two thousand different genes that we have as humans and each gene has very specific job. And. And if those genes get altered changed or This mutated clue didn't then come out the until instructions more recently. that those genes When code rare no longer behind can be read the scenes in that production Jean photos can't performance of job. the sergeant And some pepper of sessions these genes their were job released really is to only the public to protect us from cancer. in And these if photos. you start We losing discover those. Jeans. Then there you've is lost a cardboard your protection cutout for cancer. of a man Lynch holding and a Shiffman rifle, say one of the but principal this cancer image protection is obscured genes in the body by George is called Harrison p fifty three on or the t album p fifty cover, three and it's so so important we that some we people can only call see it the guardian in of the genome the when photos a cell starts that were released to recently, go awry and you can when just a cell look this up starts on the to internet. have a mutation or turned Now. into a This pre-cancer. figure has been So identified that there's a as spelling mistake Timothy and its DNA Carey who p is fifty three an American shows up on film the scene and and helps television, to fix it. actor It's almost like a big spell checker. it So was basically, taken it's hanging from out a in your nineteen cell all fifty the time six doing nothing, Stanley and Kubrick then if film your cell called the experiences killing DNA and damage, carries. it does two Character things it is starts holding to stop watch and aiming which gives a rifle. the cell time to repair the damage so normally cells are dividing and it stops the cell from dividing until the damage is repaired. The thing is it's counting is not giving the cell infinite amount of time to repair the damage if it takes too long to repair the damage, it causes the Celtic kill it self and sort of the biolog-. Article rationale there is if there's only a little bit of damage, your Celcom probably repair that without there being much of a side effect. But if there's a lot of damage Kansas are the cell isn't going to be able to repair all of that damage, very faithfully. So it can repair some of the damage correctly. But some of the damage may scape that repair. And if that's the case it's better to just kill the cell. But when those cancer protection jeans or the tumor suppressor genes when they get mutated or they don't work properly anymore. Then there's nothing protecting us from developing cancer. The cells have lost their first line of defense. Some animals, however, have a first line of defense that seems to never fail for example, only about three percent of elephants ever, get cancer and Shiffman and Lynch say that flies in the face of what you'd expect of a large animal elephants are one hundred times the size of people that means they have a hundred times as many cells, which is actually if you think about it a hundred times as many chances for randomly developing those mutations not only. That elephants live quite a long time. They live fifty sixty seventy years that many cells dividing decade after decade after decade, just by chance alone. All elephants should actually be dropping dead of cancer. But they almost never do. There's no relation between body size and the incidents of developing cancer and one level. The answer is really simple. These big things have just always to reduce their cancer risk on another level. The answer is really complicated. It's while. Okay. How are they doing that? How they're doing. That has been the subject of both Shiffman and Lynch's research examining the elephant genome. They're separate studies in the journal of the American Medical Association and the journal life show that the answer is pretty clear instead of two copies of that p fifty three gene we were talking about all humans have two copies one from their mother one from their father instead of two copies to protect them from cancer elephants had. Forty copies. So twenty times as many copies as people that could create an elephants a theoretically, nearly failsafe cancer surveillance system. One way that an organism could increase its cancer resistance is just have lots of extra copies of p fifty three. So if one of them becomes mutated and nonfunctional, there's backup redundant copies. I can take over the role of the normal copy. Lynch found extra p fifty three genes in skin cells of both Asian and African elephants from the San Diego zoo Shiffman took a similar route seeking elephant blood cells. I found myself at the local Utah, HOGAN zoo whenever blood was being drawn again for other reasons, we were able to get some of it to our lab and studying and sure enough what we learned was that these extra copies of p fifty three indeed seem to be contributing to the ability of the elephants out to rapidly remove any type of pre cancer that was occur. Shiffman put the elephants cells into a lab dish and exposed them to radiation and chemotherapy, prompting DNA damage to make them pre-cancerous. And he did the same thing with human cells to compare how they worked at what we found was that always the elephants were much more sensitive to the DNA damage. They were able to eliminate those cells with the cancer and much more quickly. And we were able to demonstrate that the way they were doing that was they were activating this p fifty three system of cell death. And so the elephants we were able to say had evolved a much more robust system for eliminating cells than have DNA damage and can go on to form cancer. And this actually makes a lot of sense. If you think about it from the perspective elephant, they're so large so many cells they can't afford to get cancer because they would go extinct that research is. One step further now with a goal of turning elephant p fifty three into something that can help people were trying to figure out is there a way that we could actually somehow deliver this elephant p fifty three to actually give to our patients to maybe treat or perhaps even one day prevent cancer. And maybe in the future who knows make a medicine that could be given to people. She hasn't been team has exposed seven different kinds of human cancer cells to elephant p fifty three with dramatic results. The cancer cells shrivel and explode killed by the elephant p fifty three similar to if you put human p fifty three into a cancer cell where able to actually use laboratory techniques to put the elephant p fifty three into it and observe the effects and some of these cancer cells, and we're able to show that some of these cancer cells in a dish are. Are actually like you said exploding undergoing as a crib a hostess from they the actually opening paragraph shrivel up of Andrew and go our into nets that death article cycle, in and paranoia then just magazine. basically turned Alastair into Crawley's little small penchant pieces for that photo finally bombing the world's disappear. greatest conspiracies So it's has been really discussed by very us in previous early, articles. but But it's in the still present case, very the analogy encouraging. can be But taken if quite extra literally p fifty three Crawley's is so protective mug is Lynch planted asks squarely why on are the elephants Beatles. Sergeant about the Pepper's only lonely animals hearts that club have band it. Elba, If this cover, is such a great arguably, answer the most to iconic image solving in pop culture the cancer problem. Why are haven't present all the focus other animals relates that to Crawley's we look back, involvement and we looked at in maybe the a Paul hundred of them. is dead Why conspiracy don't they have extra copies and of more p generally fifty three? And the the fact Beatles that they as don't a whole suggest the that Fab there might Four be some are the cornerstone trade-offs of that goes modern along day pop with having culture, extra which copies for some of fifty makes three them other inextricably studies linked that engineered with nefarious extra p workings fifty three into of mice the establishment show that the age quickly as we at shall find. least win Mr the p Crowley fifty three is has turned managed on all to the time. worm his way They didn't into the center get cancer. of this alleged But they quickly rotten got old apple, in other ways but as is that the case doesn't with happen all if things my conspiracy, syringe inured, vast so they're p go fifty flies three is between. active What only is real? in the presence. And Of DNA what is damage, indulgent fantasy but genetically of the tin engineering foil headed everyone's community immune system today? doesn't Fifty seem years to be after a likely the death strategy. hoax. Started At least not McCartney in the short run is back Shiffman on top of says the charts. the more likely His route newly released will be to album try to Egypt create station a medicine went straight using to number elephant one on DNA, the billboard two can hundred we actually and he's embarking figure out on a a worldwide way tour..

cancer Dr Vincent Lynch Shiffman Huntsman Cancer Institute DNA damage Potomac river university of Utah San Diego zoo Shiffman Dr Joshua Schiffman Elba Celcom Georgetown Beatles Alexandria Kansas professor of pediatrics university of Chicago Norbert investigator
"joshua schiffman" Discussed on News Talk KOKC 1520

News Talk KOKC 1520

09:39 min | 1 year ago

"joshua schiffman" Discussed on News Talk KOKC 1520

"Have sought significantly better treatments. Doctors study cancer is vulnerability. So they can attack cancer when it happens, and they try to understand why cancer happens in the first place. So someday, they can prevent it. Normally cells will divide when they need to and then stopped growing in the case of cancer. What happens is continued to divide over and over and over again, and they've lost the ability to stop growing that sucker Joshua Schiffman, professor of pediatrics at the university of Utah and an investigator at the Huntsman Cancer Institute there and eventually they become so large that they take over northern in the body. Sometimes they spread to different locations in the body. And if left untreated, they'll go onto almost certainly kill the patient over the course of a lifetime about forty percent of people will develop cancer. But what many people don't realize is that the first steps toward cancer are happening in our bodies all the time, but they don't get far everyday. Just. Walking down the street. We're getting hundreds of thousands if not millions of mutations, but our body is designed to actually eliminate those. So that we don't go on to develop cancer. Although even so half of all men in the third of all women will develop cancer throughout their lifetime. As we get older our ability to fix those mutations in the accumulation of those mutations that sneak by DNA repair system begins to grow, and if you live long enough, there is a pretty good chance that you may develop cancer, those are dying in your body all the time. So your body needs to replace those cells cell dies. It's replaced more or less with another healthy cell, and sometimes that process those and sell it's not quite cancer all the way, but it's pre-cancerous and your body's immune system, for example, might recognize that precancerous sell as not being quite right, and sort of mountaineering response against it and kill it. Dr Vincent Lynch is assistant professor of human genetics and organised mobile and anatomy at the university of Chicago. Sometimes that process doesn't happen in those cells escape, for example, that immune surveillance. And then they start to mutate in ways that makes it much harder for your body to recognize them as foreign and that allows him to escape the normal mechanisms that keep uncontrolled supplementation. Check why the immune system fails to detect those new -tations is the subject of a great deal of research as Shiffman says age may often have something to do with it. But obviously sometimes it doesn't why would children get cancer. Because this is really an interesting question. Right. Why would someone so young developed cancer at such an early age? They haven't lived long enough to accumulate all of those mutations that happened in time in of the environmental exposure. So we believe that there's a strong genetic component that contributes do the risk of childhood cancer. We're trying to understand exactly what that component. If she hasn't been says a few children have genetically weakened immune system, their DNA repair mechanisms are themselves mutated. So their rate of developing cancer is very high when cancer develops in any of us, a similar failure has occurred there over twenty two thousand different genes that we have as humans and each, gene. A very specific job. And if those genes get altered changed our mutated then instructions that those genes code no longer can be read in that, gene can't performance job. And some of these genes their job really is only to protect us from cancer. And if you start losing those genes, then you've lost your protection for cancer login Shiffman. Say one of the principal cancer protection genes in the body is called p fifty three or p fifty three it so important that some people call it the guardian of the genome when a cell starts to go awry when a cell starts to have a mutation or turn into a pre cancer. So that there's a spelling mistake in its DNA p fifty three shows up on the scene in helps to fix it. It's almost like a big spell checker. So basically, it's hanging out in your cell all the time. And then if your cell experiences DNA damage, it does two things it starts to stop watch. Which gives the cell time to repair the damage so normally cells are dividing and it stops the cell from dividing until the damage is repaired. The thing is it's counting is not giving this infinite amount of time to repair the damage if it takes too long to repair the damage, it causes the Celtics itself, and sort of the biological rationale. There is if there's only a little bit of damage, your can probably repair that without there being much side effects. But there's a lot of damage Kansas. Are this isn't going to be able to repair all of that debt very faithful of it can repair some of the damage correctly. But some of the damage may state that repair, and if that's the case it's better to just kill the cell. But when those cancer protection jeans or the tumor suppressor genes when they get mutated or they don't work properly anymore. Then there's nothing protecting us from developing cancer cells have lost their first line of defense. Some animals, however, have a first line of defense that seems to never fail for example, only about three percent of elephants ever, get cancer and Shiffman and Lynch say that flies in the face of what you'd expect of a large animal elephants are one hundred times the size of people that means they have one hundred times as many cells, which is actually if you think about it a hundred times as many chances for randomly developing those mutations not only that elephants live quite a long time. They live fifty sixty seventy years that many cells dividing decade after decade after decade, just by chance alone. All elephants should actually be dropping dead of cancer. But they almost never do. There's no relation. Between body size and the incidence of cancer and on one level. The answer is really simple, these big things and just evolved ways to reduce their risk on another level. The answer is really complicated. How are they doing that? How they're doing. That has been the subject of both Shiffman and Lynch's research examining the elephant, Gino, they're separate studies in the journal of the American Medical Association and the journal he life show that the answer is pretty clear instead of two p fifty three gene we were talking about all humans have two copies. One from their mother want from their father instead of two copies to protect them from cancer elephants had forty copies so twenty times as many copies as people that could create an elephants, theoretically, nearly failsafe cancer surveillance system one way that an organism could increase its Hanser resistance is lots of extra copies of. So if one of them becomes mutated and nonfunctional, there's backup redundant copies. I can take over the role of the normal. Lynch found extra fifty three genes in skin cells, both Asian and African elephants from the San Diego zoo. Shiffman. Shook a similar route seeking elephant blood cells. The local Utah HOGAN zoo whenever being drawn again for other reasons, we were able to get some of it to our lab and study it and sure enough what we learned was these extra copies of p fifty three indeed seemed to be contributing to the ability of the elephants out to rapidly remove any type of pre cancer that was occurring Shiffman. Put the elephants sales into a lab dish, and expose them to radiation and chemotherapy, prompting GNA damage to make them pre-cancerous. And he did the same thing with human cells to compare how they worked and what we found was that always the elephants sales were much more sensitive to DNA damage. They were able to eliminate those cells with the cancer in much more quickly. And we were able to demonstrate that the way they were doing that was they were activating this P fifty three system of south. And so the elephants we were able to say had evolved a much more robust system for eliminating. Cells that have DNA damage and can go on to form cancer. And this actually makes a lot of sense. If you think about it from the perspective elephant, they're so large, so many cells they can't afford to get cancer because they would go extinct that research is going one step further now with a goal of turning elephant p fifty three into something that can help people. We're trying to figure out is there a way that we could actually somehow deliver this elephant p fifty three to actually give to our patients to maybe treat or perhaps even one day prevent cancer. And maybe in the future who knows make a medicine that could be given to people. She hasn't been steam has exposed seven different kinds of human cancer cells to elephant Fifty-three with dramatic results. The cancer cells shrivel and explode killed by the elephant Fifty-three similar to if you put human p fifty three into a cancer cell where able to actually use laboratory techniques to put the elephant Fifty-three into it and observed the effects in some of. These cancer cells and were able to show that some of these cancer cells in a dish are actually like you said exploding undergoing eight to toast. They actually shrivel up and go into that death cycle, and then just basically turned into little small pieces that finally disappear. So it's really very early, but it's still very encouraging. But if extra p fifty three is so protective Lynch asks why are elephants about the only animals that have it. If this was such a great answer to solving the cancer problem. Why haven't all the other animals that we look back, and we looked at media? Why don't they have extra copies of p fifty three? And the fact that they don't suggest that there might be some trade off that goes along with having extra copies of p fifty three other studies that engineered extra fifty three into mice show that the age quickly at least win the p fifty three is turned on all the time. They didn't get cancer. But they quickly got old in other ways that doesn't happen if mice are engineered. So they're p fifty three is active only in the presence of DNA damage, but genetically engineering everyone's immune system doesn't seem to be. Likely strategy and least not in the short run Shiffman says the more likely route will be to try to create a medicine using elephant DNA, can we actually figure out a way to take this elephant fifty three and make medicine out of it to help our patients to help treat cancer that they have or maybe one day in the way future to even prevent cancer. Just like the elephants don't have cancer. We want to figure out a way. How can we make it? So that people don't have to get cancer. Again, Shiffman is hopeful, but he's also cautious. This is not a cure for cancer. He says except.

cancer Huntsman Cancer Institute Shiffman DNA damage Dr Vincent Lynch university of Utah Joshua Schiffman professor of pediatrics Kansas university of Chicago San Diego zoo investigator gene Celtics principal assistant professor journal of the American Medica
"joshua schiffman" Discussed on KDWN 720AM

KDWN 720AM

06:32 min | 2 years ago

"joshua schiffman" Discussed on KDWN 720AM

"Big things the Genesis communications network for making the show happen was, working. The dials Vic thanks. For tuning in we really. Do appreciate it don't forget to follow, us on Twitter Facebook that. After Dali show so how do we get the no cancer gene that elephants have apparently less than five percent of elephants die? From cancer researchers think they figured out why this was a study that came from the university of Chicago and elephants. Produce zombie jeans they call it can help protect the. Animal from cancer Now where do USA today they break it down they say humans and other. Animals carry one copy of a master tumor suppressor gene So we. Have one copy of this tumor suppressor so when. We, see us a cell? Go rogue a cell. Start to kind of go AWOL we've been Ken suppressant without a gene for that Elephants oh I've twenty copies scientists. Found that gene can trigger a quote zombie gene To, come back to life with a new purpose killing cells in, damage DNA Yeah. I'm a little confused by that deal I zombie I think of Walking Dead I, guess what they're saying is If there is a cell or a. Gene that, may not be active okay. Maybe a repressed or suppressed gene It could turn it into. Something that turns around and I, guess has a new sort of mission so that that's a concept of zombies zombies. Are humans that were fine then it's coming back from the dead and then turning around and. Then a nuisance that's kind of what. They're talking about here except not a nuisance and something that we want, we want cancer cells killed so cords Vincent Lynch and assistant professor human genetics at the university of Chicago, saying this is beneficial because of accident response to genetic mistakes or errors made when the DNA is being repaired. Getting rid of that cell to prevent a subsequent cancer scientists say the gene also ops elephants enjoy long lives they believe they came to existence. Twenty. Five to thirty million years. Ago And they say there were groundhog. Sized ancestors of modern elephants I don't remember my Evelyn class same elephants, pods but they said there yeah I took an evolution class I did the credits I wasn't my favorite, class 'cause I had a real tough time balancing bible and and evolution but it was cool I'm like okay. Well you know I could see how things I see the pictures again But still. Not my favorite class so researchers want to conduct more studies to find out how exactly the. Genes of elephants kill off the cells, and damage DNA then it can help humans and if we. Can figure out how to make, our body turn, around and fight off. Cancer, better in the lead to. Obviously better strategies to. Prevent entry cancer they say seventeen percent of people worldwide die of cancer and the statistics I've. Heard is one out. Of every, two. People, get some, sort of cancer now that doesn't mean died from it But one out. Of every two people we'll have, something turn cancerous whether it's little skin. Lesion whether it's breast colon prostate that's. Assuming they live long enough passed a heart attack so according to Joshua Schiffman. Professor pediatrics at the university of Utah he's an investigator at the Huntsman Cancer Institute he's as we can understand how these genomic changes are contributing to cancer, resistance then we can able to start, thinking about how do. We translate this to, our patients okay so you're, probably listening to this coin or. How do I for cancer I don't want cancer I don't want does ambi- Jean I just want to live my life I don't want to need medicine. Later I definitely don't want to have to deal with the after effects of that so mayo clinic has seven tips to reduce your risk of cancer and a, lot of, you guys already know this and you don't. Believe it when I when I tell you I don't smoke you gotta eat right you don't. Believe it but let me explain why Okay What we talk, about don't use. Tobacco we know smoking's leaked to larynx, cancer pancreatic, cancer and bladder, cancer lung, cancer and kidney, cancer cervical, cancer all sorts of. Stuff. Right Chewing tobacco to when. I tell you. To not use tobacco I I mean, I mean, avoided even second, even third, hand don't breathe, in something, that you don't need to If, someone's vaping near you get away from that, if someone's smoking a joint get away from that If there's a smoker in. The house tell them to, like leave quit smoking I. Can't tell you how many secondhand or, how many cancer cases or from secondhand You know you may not want to quit for, you well you know because I want to keep my. Weight, down and you know I like my habit and. I've lived a full life yeah but you got other people you're going to hurt So? Whether, you vape whether you smoke. Whether. You to keep in mind, new could, be causing cells to go rogue, so then you're, eating a healthy diet. Everybody hates to be told us, we got, eat healthier, you gotta healthier what does that mean well. Obviously, more fruits and vegetables okay and we're not talking potato you know we're, talking the green leafy vegetables the bright peppers that kind. Of, stuff they also found that the less the better But. The big thing is is the processed foods The more we eat. Processed foods parents the World Health Organization has found, we do have a slightly it a slightly. Higher increased risk of getting, certain types of cancer You know they said women who, eat a vegetarian diet supplemented with extra virgin olive oil and. Mixed nuts may reduce the risk of breast cancer. We also know that the Mediterranean diet. Up the heart so, we really, need, to opt for fish over red. Leaves we need to choose healthy fats.

cancer Huntsman Cancer Institute university of Chicago Twitter Genesis communications Dali Vic university of Utah USA World Health Organization mayo clinic Ken Joshua Schiffman Vincent Lynch assistant professor Professor Jean investigator
"joshua schiffman" Discussed on KDWN 720AM

KDWN 720AM

06:32 min | 2 years ago

"joshua schiffman" Discussed on KDWN 720AM

"Things the Genesis communications network for making this you'll happen Is working the dials and Vic thanks for tuning in we really appreciate it don't forget? To follow us on Twitter and Facebook that after Dolly show so how do we get the no cancer gene that. Elephants have apparently. Less than five percent of elephants die from. Cancer researchers think they figured out why this was a, study, that came from the, university, of Chicago and elephants produce zombie jeans they call them it can help protect the animal from cancer Now are USA today they break down they say humans and. Other animals carry. One copy of a master tumor suppressor gene So we have. One copy of this tumor suppressor so. When we see us cell go rogue, a cell, start to kind of go AWOL we've been can't suppress gene for that Elephants though have twenty copies sides that. Gene can trigger a quote zombie gene To come, back to life with a new purpose killing cells in, damage DNA Yeah I'm a little confused by that too I think of Walking Dead I, guess what they're saying is If, there is a cell or gene that. May not be active okay. Maybe a repressed or suppressed gene It could turn it. Into something that turns around and, has a, new sort. Of mission say that that's a concept of zombies zombies are humans that were about you know we're fine then it's coming back from the dead and then. Turning. Around and then being a. Nuisance That's kind of what they're talking about, here except not a nuisance it's something that we want. We, want cancer cells killed Vincent Lynch and assistant professor human. Genetics at the university of Chicago say this is Ben official because it acts in response. To genetic mistakes or is made when the DNA is being repaired getting, rid of, that cell. To prevent a subsequent cancer now scientists say the gene also ops elephants enjoyed long lives They believe. They, came to existence twenty five to thirty million years ago And they say there were groundhog sized amp sisters of modern elephants, I don't remember my. Evolutionary, class Saint elephants with the. Size of groundhogs but. They said there yeah I took an evolution class I did the credits I wasn't my, favorite class because I. Had a, real. Tough, time balancing, bible and evolution but it was cool I'm like. Okay, well you know I could see how things I see the pictures again But still not my favorite class so researchers want to conduct more studies to. Find out how exactly the jeans and elephants kill off the cells damage DNA then it can help humans and. If we can figure out how to make our body turn around and, fight off cancer better. Than, the lead to obviously better. Strategies to prevent entry. Cancer they say seventeen percent of people worldwide die of cancer and the statistics I've heard, is one out of. Every two, people. Get, some sort, of cancer now that doesn't mean we die from it But one out of every two. People we'll have something turn cancerous whether. It's a little skin lesion whether it's. Breast colon prostate that's assuming they live long enough pass a heart attack so. According to Joshua Schiffman professor pediatrics at the university of Utah he's an investigator at the Huntsman Cancer Institute these as we can understand how these Genova changes, are contributing to cancer, resistance then we, could able to start. Thinking about how do, we translate this to our, patients okay so you're probably listening. To this going or how do I predict there I don't want design be gene I just want to live my life, I don't want to need. Medicine later I definitely don't want to have to deal with the after effects of that so male clinic has seven tips to reduce your risk of cancer and, a lot, of you guys already know this and you. Don't believe it when I when I tell you I don't smoke you gotta eat right you. Don't believe it but let me explain why Okay What we talk, about don't use. Tobacco we know smoking's leaked to larynx, cancer pancreatic, cancer and ladder, cancer lung, cancer and kidney, cancer cervical, cancer all sorts of. Stuff. Right chewing tobacco to when I tell you to not use. Tobacco I I, mean I mean avoided even. Secondhand even third, hand don't breathe in something that you don't need. To If someone's vaping near you. Get away from, that if someone's smoking joint get away from that If there's a smoker in the. House tell them to, like leave quit smoking I can't say how many secondhand or, how many cancer cases or from secondhand You know you may not want to quit for you well you know because I want to keep. My, way down and I like my habit and I've. Lived a full life yeah but you got other people you're going to hurt So whether you whether? You, smoke with you to keep. In. Mind you could be causing, cells to, go rogue so then you're eating a healthy. Diet, everybody hates to be told us when you got eat healthier you gotta healthier well what does that mean well obviously. More, fruits and vegetables okay and we're not talking potato We're talking, the green leafy. Vegetables, the bright peppers that? Kind, of stuff they also found. That. The less obese the better But the big thing is is the processed foods, the more we eat processed foods apparently the. World Health, Organization has, found we do have a slightly, it a slightly higher. Increased risk of getting certain types of cancer you know they. Said women who eat a Mediterranean diet supplemented with extra virgin. Olive oil mixed nuts may reduce the risk of breast cancer. We also know that the Mediterranean diet could up. The heart so we really need to. Opt for fish over red meat, we need to, choose.

cancer Huntsman Cancer Institute Gene university of Chicago Twitter Chicago USA Genesis communications skin lesion Facebook Vic university of Utah Vincent Lynch assistant professor Joshua Schiffman Ben official professor investigator