19 Burst results for "Jim Allison"

"jim allison" Discussed on What It Takes

What It Takes

09:24 min | 10 months ago

"jim allison" Discussed on What It Takes

"Back. You refused their ops. That our oldest brother who was a rancher jacket Rolla bulldogs with one hand. Not as hard as he paid for the long cancer. But you know he had chemo. I got Saw Him occasionally to in an oxygen tent reduced from his huge full alive cowboy this sacred bones. Anyway I got this so you saw cancer really up close and what. How was eating people killing people and you yourself had cancer three times actually luckily my brushes with cancer. They've been taught early. My eye prostate cancer off. I have two brothers. Middle Brother died of it. All three of us have prostate cancer and Mine was caught pretty early but his was so severe and so rapid that Normally probably would have just waited but time they decided the best thing to do is take it out. Even though they could have probably waited a year or two made a decision. You WanNa take a chance given how fast your brother's progress so so. When did you decide you know? I WANNA BE CANCER. You know the asset a lot. I think that was always seminole or something you know but it's not that I said I'm going to cure cancer. I got into science. I said I WANNA. I really wanted to find something. I was interested in when I was in graduate school. I did a one of my projects. Did doing my page directly on on how to treat cancer but ultimately I decided that wasn't GonNa go that route. I got into the immune system Trained in chemistry biochemistry and took a course algae when I was in cal- undergraduate and heard about this paper. Actually the Max Brand Jacques Miller and these two guys did were but these guys discovered two components the system b cells and t cells. And I said I gotta get into this understand this. This is the coolest thing I've ever heard about all this work. That's come from. There's and they're just now. Getting record is the week before this interview. In fact Max. Cuper and Jacques Miller were awarded the lasker prize the most prestigious science prize. In the United States apprise Jim Allison one in two thousand fifteen aurora. Maximum voter. Can't believe my work. Everybody Springs from yours. Can you explain to the people listening? You Know How. Your cancer cure works. Yeah so it's not that hard people have been you know your immune system of course has the ability particularly T. cells to detect. When there's something wrong and I say that I mean because that kid include infections you know I mean it's just a very good obviously at detecting when you've got a virus infection or you got bacteria and dealing with them and they know how to deal with the bacteria not hurt your cells and that's the fascinating thing about him and they do. This is recognized. Not Self which is it. Sounds like a complicated thing. But basically they know that that immune system as receptors that enables it figure out when there's something going on inside a cell that shouldn't be there they don't need to know what it is but just out to be there at some new And Way that works is pretty fast. They're these receptors generated individually on different T. cells to probably got somewhere around fifty million different ones. And you maybe maybe a hundred. Nobody knows for sure but they each can recognize something different but when they recognize something. That shouldn't be either like a virus infected cell. They'll recognize can recognize things. That virus causes the cell to make. That aren't no you and they respond to that by expanding from a small number two a lot and then killing it so we've got these hunting. Tens of millions of different sow such. You've got a diverse repertoire. Of course then you've got to get hundreds of thousands of one or two or whatever it is that can help you. That's the cool part of the immune system because that's where the critical switches t-cells see something and it's got to quickly generate hundred thousand copies of itself. You know so that you get the army to go and swarm around your body go through all your tissues and look for stuff and hopefully kill it so they could do that to cancer as well. Your innovation was the antibody. Well it was to figure out people understood that process. You know. T-cells recognized expand. They do their function. The contract you know most of them die and then you end up with some that. Are there for the rest of your life. I mean that's the really cool thing about immune system is because once it develops you've got it for the rest of your life these renewing t-cells key. Nobody really understand what starter they thought it was. Just switch you flip it and so nine hundred eighty two we worked out the structure of the Antigen receptor. Which is the molecule like? Ignition switch in the car. That's that thing that there's you know. Tens of millions of difference in your body and people thought well you just flip that and that's it so the people that have been trying for decades to vaccinate people in failed hundreds of failed trials just trying to back because they really didn't appreciate that you can't just there is no single switch is flipped it takes turns out. There's a gas paddle wheelers another signal that it's a way of keeping your safe from. Tc does get back to when they ought to. So for the T. cells to spring into action when they detect something awry in other cells of the body. They need the right signal to get them. Started the ignition. And they need a secondary signal the gas pedal but what was the next step that there was a break. This was the key thing. There's another molecule that nobody had found before really expected impact. There is a molecule that people thought was another gas pedal. But we used to. We showed that it was Nah. It was actually a break. Because when those t cells you it gets the first two signals. Divide not crazy so you go from. I don't know making these numbers up ten to five hundred thousand cells in a week. You can't let that keep going. You know you've got to have a way of stopping that it'll kill you and You know I mean you can't do body can't put all the energy and everything just producing those t cells in probably do. What are they go? You know you. Can't you gotTa Stop That in control? And that's what this molecule does except in cancer kicks in prematurely for you know I can go into the race but but that's basically what we've found but and also told us as it's turned on when the gets those other two signals so when people try to immunize naming is aiming is what we figured out was after about the first you know few times I mean. Is there actually turning on the brakes off the gas pedal? That's why didn't work because the TESOL goes into this. Let's stop now pays anyway. We found out how to stop that just disabled the brakes time. So that's what we do is and and Mice I had to do is just inject this one. Antibody that interferes with that breaking mechanism. That's the main system. Keep going for as long as that drugs around the T. cells could just keep going going and they just keep killing tumors and so in mice. We could have dejected. And of course like about it was the kind of cancer doesn't matter because you're not treating the cancer. The work had nothing to do with cancer. Nothing directly to do with cancer because it was really basic research into how the immune system operates to reiterate. What kicks it into high gear. And what tells it when it's time to shut down you now? I asked you to remember the name of Jim. Allison's band well now's your moment that molecule and the T. cell which signals the body's immune system to step on the breaks. It's called a checkpoint and the medicine that James Allison eventually developed to disable those breaks is called a checkpoint inhibitor. It used to be the kind of cancer out now. Are you burned to cut it out or poisoning right and now? Instead of radiation or chemo or surgery. You're trying to turn the immune system to kill the immune system. Do the job without doing any of that other stuff. Mary Jordan asked. Jim Allison to tell the story of that breakthrough moment when he realized that. Disabling the breaks on the immune system with an antibody.

cancer Jim Allison chemo Jacques Miller United States cal James Allison Max Mary Jordan Cuper
"jim allison" Discussed on KGO 810

KGO 810

02:01 min | 10 months ago

"jim allison" Discussed on KGO 810

"Cases I can't stress that enough people are going to take the news of more cases and some will get scared and some should take it as it is which is a step in the right direction this is where we need to go did you see this the comment from Rudy go bear the basketball player was working college eyes we apologize but he's not showing any symptoms yet he was allowed to get tested which Adams just kind of surprised me compare yeah ice agents we have in the bay area right I think you know did you have contact with somebody because that's always been the first thing were you in contact with anybody that had it we will be speaking to a bart spokesperson Jim Allison after the top of the hour news updating the coronavirus here in the bay area KGO San Francisco a cumulus stations download the tune in app so you can take KGO eight ten with you wherever you go special report corona virus update businesses big and small facing serious economic challenges because of covert nineteen have been given New Hope in the form of a potential government stimulus package Michael to scan E. as in with that John the White House is proposing a roughly eight hundred fifty billion dollar emergency stimulus to address the economic cost of the corona virus pandemic the request is being outlined to Senate Republicans today and will aim to provide relief for small businesses and the airline industry and will include a massive tax cut for wage earners at the same time Democrats have proposed their own seven hundred fifty billion dollar package leaders in Ohio called off today's democratic primary election just hours before polls were set to open fears over voters and poll workers contracting coronavirus led to the abrupt decision however voters in Florida Arizona and Illinois have been going to the polls I'm John trout after yesterday's dismal stock performance Steve casting bam is watching today's activity on Wall Street at the opening bell stock prices started rising for a.

Florida Arizona Senate bart Adams basketball Steve John trout Illinois Rudy Ohio White House Michael San Francisco Jim Allison
Everything You Wanted to Know About Bay Area Rapid Transit (BART)

Bay Curious

08:34 min | 1 year ago

Everything You Wanted to Know About Bay Area Rapid Transit (BART)

"I bring you in here because we wanna do effectively like a art special. We get a ton of questions about Bart and you are as far as I'm concerned. The expert in my life. Oh okay well. I'm flattered to hear that. How long have you been covering transit and paying attention to what Barnabas well you know. I've paid attention to what bar does since the mid seventy S.. That's when I moved here and I started taking Bart right then. I think my first Bart ride was nineteen seventy-three. I went to a warriors game when the system was no more than in a year old. What was your first impression. When I came out here. Fart was sort of this rumor. It had gotten national coverage right because they were doing all this crazy he stuff. They were going to go eighty miles an hour. The was much faster than the commute trains went in Chicago. It seems space age and The shape of the cars configuration of the cars that was different from anything I had seen so yeah. It was a cool experience and the other thing was it. was you know it was kind of cheap. Listen there was a time when the short hop rides were twenty five cents. Actually that was just in downtown Oakland in downtown San Francisco although a quarter got a lot further in nineteen seventy three than it does today. I mean things are really different. I mean listen. The other thing about this system was it was not heavily used in the past ten years. Here's the ridership just skyrocketed when the economy came back after the great recession. And that's really one of the chief reasons we've had such a crisis of crowding. Well I think that kind of tease us up to a couple of questions that we got from listeners So this first one comes from mark and he wants to know in. Its nearly fifty years of existence. Why has taken so long to extend into Santa Clara County and only nominally portrait into San Mateo County and never expanded into any any of the North Bay counties. Well there's a complicated history to that but I mean the simple version is that Bay Area Counties had the choice of opting into Bart art in the early sixties and some opted out Santa Clara and San Mateo opted out. There was some talk about a going up to the North Bay going to Marin that history is even more complicated there were engineering studies at showed it was feasible to put a track below the roadway on the Golden Gate Bridge and get the trains over. There were three engineering studies. That found that was fine. One sponsored by the Golden Gate Bridge district did not support that idea but that was on the table and when San Mateo County opted out the backers of Bart then no longer thought that the Marin idea would be feasible so they sort of pulled back on that and in the meantime you know the Golden Gate Bridge district never really liked the idea because back then Bart would have been competition for the service they were offering so far has only gone into Santa Clara and San Mateo detail in recent history because the people in those counties decided they wanted barred. Well I WANNA go back to the early days of the the beginning of Bart. We've got a question from listener. Who wants to know. How did they build the underwater tunnels for Bart. So this is one of the great epochs of the Bart Construction Story It took years and years to design the system that they used and the tube was built in sections they would build the sections in pieces that were longer within a football field and then when they were done with all that work they would tow the section of the tube out into the bay and then they would lower the tube which was sealed both ends down to its location which was of course very precisely marked and divers would join join the sections of Tube together one at a time so that joining the meant they were being welded together and bolted and the to was resting in a shallow trench that had been dug before the sections were brought out? So it took about three years of actual construction auction to get that all together. And that's the Tube we have today the other thing the other aspect I find fascinating is that you know you're actually going down. Pretty pretty steeply sides of the bay where you start up on the Oakland. And you're you're above ground say fifty feet and then you you the plunge under the bay this thing is a one hundred and thirty feet below the bay and then you have to come up on the San Francisco side to connect to the tunnel at Embarcadero cricket hero. The experiences a writer is pretty flat. You kinda feel you're just going straight across. Oh that's right. There are a couple of places where you actually change elevation under the water and It doesn't really feel like you're going up or down but that's exactly what you're doing. Let's get to our next question now. I WANNA go down into the Bart Stations. A couple parts ten questions. So this comes from Brad Meier. I've noticed that they're empty. Newsstands at some stations. What is the history. And why are they closed. And they could provide jobs to vendors in income to Bart. I'm asking because other transit systems around the country have newsstands open in their stations. So we came down to Bart's Montgomery Street station to answer Brad's question and standing looking at where one of these kiosks ask stood. Listen to deal with those kiosks was it was mainly an outlet for the chronicle and examiner the to San Francisco. Newspapers both are still in existence. They used to have a joint operating agreement and so vendors deal both of them. The Kiosk were actually very limited in size so not really amenable to the much bigger business. But the main thing that's happened is the newspapers Don't circulate by selling on the street anymore. Selling and Transit Stations Asians and that's due to the Internet and its do smartphones where people are carrying that information with them instead of having a paper medium in terms arms of whether these could be re purposed for another kind of business. Well maybe but again they're small A bit smaller. You're perhaps in the ones that you see in New York and Chicago and some other cities but the other thing is those kiosks generally sell other kinds of goods so food and Barton generally inside the station's discourages consuming food. We know that from a very recent famous incident where somebody was detained cited for eating breakfast sandwich at the Pleasant Hill station. Those are the main considerations and why these kiosks just aren't going going thing anymore but there is one sort of cool thing about this kiosk if you actually walk over to where used to stand here at the eastern end of the Montgomery Street concourse. Here's an audio effect. If you stand exactly where the kiosk was. Here's kind of an echo chamber here and is right for experimentation enjoy writing and now we have to go catcher train all right well. Let's get to our next question. I'm Jay Quigley and I live even Oakland at West Oakland Bart Station. Their ads right next to the third rail. How on Earth did they change those out without getting electrocuted. I asked this question because every time I look at the third rail I get terrified. Well you know the third rail is something you don't WanNa touch under any circumstances it's very high voltage and Instant death or at least extremely serious injury if you do come into contact with it so what they do is You Know Bart is shut down for a part of every day. Trains really stop running around one. Am and then. There's a window of time between one and four in the morning when a lot of maintenance activity takes place they shut down the third rail. I was told by Jim. Allison at Bart that they call it laying down a blanket. Meaning you know making that area like as if you're covering the rail with a blanket to make it safe they're not physically doing that and then Once the rails are de energized than the workers can work safely there

Bart San Francisco Oakland Bart Stations San Mateo County Golden Gate Bridge West Oakland Bart Station San Mateo Brad Meier Marin Barnabas Santa Clara Santa Clara County North Bay Chicago Bay Area Counties Football Writer
"jim allison" Discussed on KCBS All News

KCBS All News

01:50 min | 1 year ago

"jim allison" Discussed on KCBS All News

"KCBS weather a mix of sun and clouds high sixties seventies eighties right now we're going to will go live again to Jim Allison from bar to join us on the KCBS news like Jimmy had an update for us on the person who was on the tracks well yes so it which are getting ready to power up the track and it appears that the person is out of the track way being transported we don't have a condition on this person but hopefully the person is being transported to a hospital to be treated but as George mentioned we are single tracking at that station and the fact that the crews were able to get the person on the track way relatively quickly these me to believe that we might be able to resume normal service and reasonable amount of time okay so but for now you are already single tracking we are single tracking is George match that's right how long is the delays well and it's really difficult to gauge of just call major delays at this point so that could be up to twenty minutes nothing you tell people to find another way to cross the bay no no no our train operators are making announcements to passengers on the trains that that they're operating so the best thing to do is when you get on a train listen to the train operator okay great well thanks for updating us and we will talk to you again it's Jim Allison from bart there now single tracking they removed the person from the train tracks don't really know about the condition of that person yet and how that person and she got on the tracks but anyway the person's off the tracks they are going to re power and get traffic going both directions for now though there's just a single tracking through the area of course it's pretty crowded a bar keep it tuned to KCBS it's ten forty what will be back in a couple minutes with more news the new Macy's backstage open Saturday inside Macy's fashion center at Pentagon city our name says Macy's but it's totally different stuff like fashion finds home decor toys hair.

Jim Allison Jimmy George KCBS Macy twenty minutes
"jim allison" Discussed on KCBS All News

KCBS All News

01:47 min | 1 year ago

"jim allison" Discussed on KCBS All News

"Mainstream audiences and catapulted Nelson to the very top of country music CBS news time ten thirty eight we are ready for a part update now here's George raft we just got an update from bart centrally closure at Montgomery street station has meant that for about the last twenty minutes or so there've been no trains getting through the transbay tube they are now however going to start moving trains from the East Bay into San Francisco and as you spoke a little earlier Rebecca with Jim Allison from bart we ask about single tracking they had not yet set that up now they are able to do so so that means they will be able to get some trains through the Montgomery street station but right now they are stacked up at Oakland west trying to get into the city the bay bridge westbound into San Francisco is now backing up into the macarthur maze were rest still slow all the way from five eighty and the right on six eighty southbound is jammed up trying to get down the Alamo an accident southbound at love Warner the reason still slow Livermore Pleasanton day facts chilled not a body collision KM street sweepers because in the southbound CJD is they had passed gas will be in the right lane on their way to Fremont traffic slows at stone ridge westbound five eighty also have you through Dublin pretty much from Isabel to hop yard at Mountain View stall on one oh one north bound is been cleared so that what that's why the traffic got so badly backed up westbound on highway two thirty seven and won a one north your next update ten forty eight on the traffic leader KCBS weather a mix of sun and clouds high sixties seventies eighties right now we're going to will go live again to Jim Allison from bar to join us on the KCBS news like Jimmy.

Isabel KCBS Mountain View Fremont Livermore Pleasanton Oakland George CBS Jimmy Nelson Dublin Warner Alamo Jim Allison Rebecca San Francisco East Bay Montgomery street station twenty minutes
"jim allison" Discussed on KCBS All News

KCBS All News

01:31 min | 2 years ago

"jim allison" Discussed on KCBS All News

"At the bay area's news station. KCBS? The storm is arriving. Thanks for joining us. I'm Geoff bell. I'm Patty rising. Here's what's happening as Civic Center Bart station downtown San Francisco is closed this afternoon because of flooding on the platform, we're going to get the latest we're joined on the KCBS ring central Newsline, by Bart. Spokesman Jim Allison Jim what happened? So there was a problem on the Muny level as you probably know that station shared by Uni, and Bart and Munich is above there was a problem with the shaft, we're not quite sure what the problem was from our perspective here, but the water leaked down onto the bark platform, and so we've closed it for the time being. So Jim just to be clear when we say that the station is closed. It's closed riders coming and going, but trains are going through it. Trains are going through it. They're not stopping. Yes. It's closed for people entering or exiting. And of course, the big question when do you think is going to be reopened as the afternoon commute? I guess it's underway. It's getting started for sure I think people are probably leaving early today. But I hate to speculate, but I did hear on the radio here. The the radio that we use to communicate among personnel that it seemed like it was not going to be a long issue. A an issue that would take too long to resolve. All right. We'll be hope you write about that. Jim Allison with Bart. Again. The headline there is at the Civic Center, Bart station, currently closed riders coming and going, but trains are going through and our own Marquis Schaefer heading to the scene. She's going to bring us more. When she gets there..

KCBS Bart Civic Center Bart Jim Allison Bart station Jim Geoff bell Civic Center Marquis Schaefer Uni San Francisco Munich
"jim allison" Discussed on Newsradio 1200 WOAI

Newsradio 1200 WOAI

03:04 min | 2 years ago

"jim allison" Discussed on Newsradio 1200 WOAI

"Oh, I orange Baptist church. And then we'd go to different places, and we would go Christmas. Caroline. In a small town. People are happy that you showed up to knock on the door old people come to the door. And you know, you got your low Caroline group out there and you go to town. That's a nice thing. I've missed that. So I'm going to try to recreate that December nineteenth s Michael's birthday, by the way. But we're having his party on a different day. So we're going to do some Christmas. Caroline that night. It's going to be fun, and I need acquired tell me about your choir. Who they are what their ages and assured me that chalk can do all the classics. Because that's the important part MD Anderson's. Jim Allison, boy, this is a big honour will receive his Nobel prize today in science from the king of Sweden. He plans to give the prize money to charity. Allison was awarded the prize for his breakthrough discovery in immunotherapy that has revolutionized cancer treatment. The awards ceremony in Stockholm begins at nine thirty central this morning. Last week Allison visited the Nobel museum where he signed the bottom of a chair at bistro. Nobel a tradition among Nobel recipients. Do you know the story behind the Nobel prize? I've ever told you this Alfred Nobel was childless living in France. And he was a dynamite. He was an arm sky, but dynamite was at the time nuclear weaponry. And he was together and moving it. He was the guy you bought you bought it from and he was so hated by the pacifist of the era. That they wrote an obituary it was believed that he had died. I think it was his brother that had died. Instead. And the obituary was about what an awful human being. He was just absolutely terrible. Alfred Nobel has died and we're glad he's terrible and that cost him to begin to repair his image. So he started donating money to found this Nobel prize and our own Houston's own MD Anderson's. Jim Allison will receive this more. You know, he's married to an Indian woman. Pod mini Sharma? She's also an MD Anderson. Professor, she is his longtime research collaborator. And of course, his wife. There's quite a tradition behind winning this Nobel prize and science the different things. The different thing you hand over some things for their museum some artifacts. And I'll tell you just a moment what he hindered. The Michael berry show. Please clap. My name is Scott. My name is John whoever you are. My name is Blakely..

Nobel prize Alfred Nobel Jim Allison Caroline Nobel Nobel museum MD Anderson Michael berry orange Baptist church Stockholm Blakely Sweden Anderson John Scott research collaborator France Professor Houston
"jim allison" Discussed on StarTalk Radio

StarTalk Radio

02:53 min | 2 years ago

"jim allison" Discussed on StarTalk Radio

"Rebecca final star cosmic queries. Addition check Knight, the subject is curing cancer. And we got all up in the face. Dr. Jim allison. Yes. He's here with us here, and now just won the Nobel prize in human physiology, one of the categories of the Nobel prize, and we've been we've been picking his brain about this with our with our query again, Jim thanks for being on star talk. And let's continue. What do you have? I write. This is Kyle Coon from Facebook and Kyle is from Airdrie Canada and says is their chance if we never find a cure for many types of camps cancers, humans will one day in a Darwinian sense of all out of cancer. So a little awkwardly worded. But what he's saying is can we evolve if it's killing us if it's killing us can we evolve beyond cancer kind of like selective? Breeding the sense. Where the small percentage of people who do not develop cancer will be naturally pre-selected to continue propagating the species. Interesting question, not sure if that's your expertise, but well, an Lucien is Jovan by survival of the fittest. You know, so it works on on development spent this what you made your children and Alicia doesn't give a damn Patchett. So there's not allowed to evolutionary pressure to, you know, so they childhood cancers and stuff there may be pressure. But I really don't think that there's going to be a selection against people that are old to get cancer. Because they just read that doesn't make you veteran able to reproduce. I guess society could change enough for that different. But. I don't think it would have babies. You know, nature's done with you. Right. Reggie propagated. Your your does. That's really what the whole thing is. About sending your DNA into the future. Right. And what happens afterwards? No one gives it rat's ass about. Wow. Yeah. Yeah. Boy nature. What Mr. C is? Oh, well, there you go. That's that was a great question, then and and very disturbing answer. All right, by the way. So, you know, the Darwin award given annually to the person who does something completely stupid and ends up dying for having done. So right. Okay. It's called the Darwin award, but you can only get that award. If you've died for doing something stupid and have not yet had kids right because then you already sent your stupidity full, then you would have read. So it's it's calling the heard as it is given out every year, and you go, and if you don't wanna be a winner of it because it means you're dead true. At why? And stupid, and that's no way to go through life. Did..

Dr. Jim allison Nobel prize cancer Kyle Coon Reggie Rebecca Facebook Alicia Airdrie Canada Mr. C one day
"jim allison" Discussed on StarTalk Radio

StarTalk Radio

02:17 min | 2 years ago

"jim allison" Discussed on StarTalk Radio

"Immediately go into your lungs and then ultimate in the bladder. If it's eaten a lot of it gets gets digested away. I don't think I don't think there's any data showing with Would it. it has caused cancer? Other matters doubt. If it would it was just, you know, cookies or something. Okay. Brownies brownies. Or any number of edibles? Very cool. I don't know why. But I feel a need to buy a ticket to Colorado. Time for one more question in this segment. Okay. This is jet Daniel Junius or Junius wants to know, this is a plausible to kill cancer with kreisls surgery. Yes. Yes. Absolutely. And we've done some experiments with that just be clear cry. Oh is cold? Freezing probe is done is done. In the clinic. A lot particularly kidney cancer, breast cancer. It's gotta be localized. But we we showed in mice that if you had to tumors opposite sides of mouse, you could cure what Obama phrasing it maybe other mental loan, but injecting are drug just after you've froze the first one because that makes him follow parted them primes, the T cells go kill the other one. So that's now in clinical trials in kidney cancer, breast cancer. Wow. That sounds like a military operation. We will conquer this side of the enemy. Yes. Re deputized them in our. Army? Did we created a BI to go kill cancer super cool? All right. So Jim we can take a quick break. And we'll be back for a final segment star club cosmic queries. How do you cure cancer? Hey, thanks to Nord VPN for sponsoring today's show for those of.

cancer kidney cancer Daniel Junius Obama Colorado Jim Army
"jim allison" Discussed on StarTalk Radio

StarTalk Radio

05:18 min | 2 years ago

"jim allison" Discussed on StarTalk Radio

"Much to everything in moderation. To stay healthy, Cam good. You had a good mind. My mom used to tell me you're going down and. House out there. You got a dime. So I think. Jim just said that I can stop eating kale. That's what. I think I heard him say that he just a little bit of it, right? In moderation moderation of kale? Kale, kale was a garnish what happened to our? I guest and kale. All right here, we go. Jeff Farris from Facebook wants to know this estimated about one third of the people who get cancer are genetically predisposed to it. Where are we on the ability to do testing to predict the outcome? And how reliable is the current state of testing is having a genetic marker of fifty percent positive or seventy present positive a good means of being able to tell. Yeah, I'm not sure it's has thirty percent of significant number arm. But but breast cancer, for example, to some extent ovarian cancer in women can because by brecca mutations. And so and by the way, Dr just for all of those who are unlike made that know exactly what Brad mutations are what what are what are the over? I bound to to just by studying backwards that women with breast catcher head very often had this Jane remember what stands for but anyway. Jayco BRCA best answer, I guess be says for breast cancer. But but we don't now there's involved in DNA keeping your genes normal. You know? Visit heritage if women inherits one copy for her mom the other copy that could be dangerous. So, you know, it's something that will breast cancer. But a lot of other kinds of catcher dot quite as definitive is that prostate cancer. We know that if you have a brother that got it you're twice as likely to get it. But nobody's been able to put their finger on. Why that is yet? So on on what part of the genetic of your genome is then responsible. So so with the with the Brakha, it's it correct me if I'm wrong is that the first time, you have such high level confidence that a person will get cancer that you people are convinced have preventative surgery that does happen is right, right? But there's no other cancer prediction for which that is advise. Is that correct? Not that I'm aware of. Yeah. This is delete Cunningham Troia and. He says my five year old daughter or granddaughter was diagnosed in may with acute lymphoblastic leukemia Pete since it is generated in the marrow. Is there anything new on the horizon? So are you familiar with this particular cancer, and in any research that might be encouraging? I'm not I'm not an expert on that comes as, but I can tell you that there is there is activity at sing these these check my blockers as we call. Work leukemia's and adults, and they do cases the the works early. It only started a few years ago, but there's some hesitation and using them in developing adolescence or younger kids because people are somewhat worried about I mean changes while your body's changing and everything, but I would be gets there. Sooner or later. Oh, well, that's courage. You go. That's a very cool therapy called car T. So which is an engineered Kennedy sell. It's good back into the Kimia. Patients might also have promised. It has been used kids. All right. So two things to perhaps look forward to. And of course, we wish Denise granddaughter all the best. This is Cheryl squeaker Carter. And she says is there actually any scientific research being done on cannabis and the effects it has on cancer. Yeah. I think there's quite a bit with most of its, you know, is giving to will become palliative kidding today. Patients more comfortable, less nauseous when they're getting chemotherapy. I don't think there's any evidence that cannabis. You know could be used to treat cancer itself. And in fact, you know, if smoked it has some of the same carcinogens did actually spoke Tabatha tobacco has that much much lower level. So so far as I know the only things being said is just helping patients feel better the carcinogenic components. Does that though they're much smaller? Does it matter? How you ingest the cannabis as and what role could then play in these cancer? That's yeah..

breast cancer cannabis leukemia Jayco Jim Carter Cunningham Troia Tabatha tobacco Facebook Jeff Farris Brad Jane Kimia Kennedy Denise Pete Cheryl thirty percent fifty percent five year
"jim allison" Discussed on StarTalk Radio

StarTalk Radio

05:21 min | 2 years ago

"jim allison" Discussed on StarTalk Radio

"Exception. We're back starts. We have with us. Dr Jim Allison, freshly minted Nobel laureates we and he took time out of what we know is an over subscribed day of his to just share with us, his insights cancer is and how it works and how how would try to fight it. And we it's 'cause Macquarie's so keep it going. Here's the next question. This is from a friend. Hey, doc, what are you going to do with all that money? You realize he's got a split three ways. You realize oh what? That's not right, or whatever the total money is he gets a fraction of it. Okay. Let's start there. All right. Okay. Jim what are you gonna do? Just one other just to as as to the government's third when I get. Wait a minute. Are you telling me that they tax you on your Nobel prize? That is that's disgraceful disgraceful. Okay. So he gets half the prize. And then the government gets like the other. Okay. So what are you going to do with the forty dollars and eighty nine cents? Probably give it to give a lot of it to some. Cancer research organizations, and I think I need to do. I will let you do that wasn't even serious about the jerking around. We was great. All of this stuff about the no pill prize. All right. Let's go to a real question. As a matter of fact, this should have been the first question before our patriotic. And this is from naira n- Reich on Instagram who says what is cancer. At least, you know, a lot of people may not know exactly what cancer is. That's true. We still know exact cancer is, but a lot of people have referred to sort of a social disease, you know, complex Arcus different cancer cells and they've got to play nicely with each other. You know to go ARGUS certain size at stop and to be able to heal wounds. But this stop wanting damn stay where they're put not go someplace else it so cancers just. Is sort of. What is is hyper pleasure meeting starts growing fast doesn't stop. But that's basically just sells losing the normal could shows that that make cooperate with all other cells to make you what you are. And these are your cells do not exterior alien alien in cosmic sense. But just foreign but foreign foreign some foreign thing in your body that you could just remove and all his well. Your body is misbehaving is that a fair way to characterize it. Yeah. You're the sales in your body. Some yourselves your body misbehaving and causing damage to the cells around. Just by getting too big. But no the case too vague destroying tissues. Cool. All right. All right. Let's move onto Rene Douglas from Pittsburgh. And she wants to know this. If a curious found would occur all cancers, or are there different types of cancers would each one need a different Heure and just as a follow up. Is there a means of achieving a universal cure is probably easier. When it actually question of it used to be that, they're they're called personalized therapies, reach patient and. Try to figure out where where the mutation was causing the cell to be a cancer cell, and those are not to be good curing cash because there's so many mutations in a lot of cancer cells is that there is not just one Jerry kill ourselves mutation. There's others jug done works anymore. EMT changed it. But one of beauty of beg me Mian system. Go is. And in addition to the T cells to attack to resist they can recognize, you know, many many of the mutation. So they become a multi, you know, bigger army that could hit up to. Targets as since it's not directed against any specific thing. You know, what that is when I thought of this in the mid nineties, this could be a way of treating all catches, and you know, that has not been realized there are limits that have to do with just a number of mutations other properties had been cancers like lung cancer melanoma bladder kidney, these could be cheered fraction of patients these can be cured down. But we. We know for melanoma was the most experienced over twenty percent of people live ten years after a single treatment. And that's maybe going up to about sixty percent. But other ones like good bless Toma. Which is what McCain data? We just haven't made much progress there, and where you know, working my my wife productive pathway Sharma..

cancer Dr Jim Allison Nobel prize Rene Douglas Macquarie McCain Pittsburgh Reich Jerry twenty percent forty dollars sixty percent ten years
"jim allison" Discussed on StarTalk Radio

StarTalk Radio

02:13 min | 2 years ago

"jim allison" Discussed on StarTalk Radio

"They're named after the the tissue that they came from. Then the next step was when people studying the cancer, biology realized that. D mutations that caused them were were very different than they sort of. They all were different shaded back. What causative gene mutation was gay rash on your custom Allison one hundred cats. Ryan there. Okay. So that is the trend line. Yeah. You have a when we look at them. Now. It's it's sorta we're broadening again, we just look at Kennedy too big amino genetic, meaning they provoke immune response. So they don't. Okay. Right instead of any individual type of cancer and just very quickly before we move on could Sombor almost time for the settlement by I you mentioned something occurs. Refashioned that I think is very important. And I just caught the the way you phrased it every teenager might want to look into HP now as that including men because you know, when when you're a guy and eighteen you hear cervical cancer, you lay I'm good. I'm. I'm I don't have to worry about maybe good. But the women that you encounter may not be good later on because manner. He said to Matic, you get it and you pass it. But you never know you had it. And so, you know mandate to get it as well. So that that was my point is that this is something that affects everyone and the vaccine we know leads to the direct prevention of cervical cancer in women because it fights the virus that causes it in women. Correct. Exactly the same system destroys the Paris before it could do anything fantastic. Wow. Okay. We're gonna take our first break. You're listening to a special cosmic queries addition where we are privileged and honored to have the freshly minted Nobel laureate. Loud sounds so cool, man. Meant it. Nobel laureate actually rented, right? They just made Dr. Stamp Iverson because. Dr Jim Allison from university, Texas medical center in Houston. We'll be right back. Get it..

cervical cancer Dr Jim Allison cancer Nobel Dr. Stamp Iverson Matic Ryan HP Kennedy Sombor Texas medical center Paris Houston
"jim allison" Discussed on StarTalk Radio

StarTalk Radio

05:20 min | 2 years ago

"jim allison" Discussed on StarTalk Radio

"By honcho, and his group shares the project that that response rate goes up to sixty percent. Wow. So that's the highest. And there's no reason to take those patients will be around for ten years while we have to wait. See we don't know yet. Hopeful. But also it's been approved by the food Drug administration for lung cancer kidney cancer, bladder catcher Hodgkin's follow so cancer head net. Catcher few others. Fifteen indications has been approved for and burying response. Rates for from just being to fifty percent. And so it's that that basic defector proves any doctor, of course to prescribe them. I just heard you say head and neck cancer, which I've never heard of until this moment, and that's not brain in throat that's actually heading. It's is from either smoking are human papillomavirus. The people that treat Abaco ours. Ours could a lot. Okay. Okay. So I quick question. Just before we go to our fan base. And because that they're the ones that supplied the foundation of questions that is going to make this show. Procedurally if you can demonstrate that something you're working on cures cancer in mice or rats. Do you have to have human trials for to still be approved by the FDA? Yeah. Absolutely. When I started on this a lot of people said to be anybody, get your cash advice. Oh, wow. That's funny that my gosh. Yeah. So that you know that we call those haters. People need education. But but yeah, you have to have the trials to prove it safe in. You know to do advocacy. Yeah. But what something that was revealed in a movie that Dallas buyers club? The Dallas buyers club the FDA was the enemy. And then in the said, the FDA loosened some rules to get drug into use even before trials are fully completed. If I'm about to die to say, oh, this might not be this drug might be safe for you. But it could cure me an entirely that the F the efficacy of that feels wrong. Yeah. It's a complicated. Subject only. My brother. Ed, metastatic prostate cancer. And while we were developing this jug, and I really wanted to get it to him. But could the reason his, you know, the companies that are helped Beverly I couldn't develop by myself had teamed up with a tech company to actually make the drug itself, then they had to get approved do these trials which they can only make so much. And if they try on people outside of a trial and hurt them or or killed him. Then that's that ruins the drug. You know, so. The risk of slowing down. It's just a. And these trials I think what they've done especially since two issues you're talking about they become a lot faster now. So this class of drugs, they they've really greased rails on it. Now where enough experience rated, you know, if you showed Alaska see that's good enough because they don't now about the safety. Yeah. Wow. So Chuck, let's go to our fan base. Okay. So do you have Kyle Ryan Toth from patriot and says this along with our search for curing cancer once eight forms are we researching ways to prevent cancer from even developing a yes. And that that's that's a great question way. Yeah. We working on that. Actually, there's some vaccines for H P and do cervical cancer, for example that just word of wisdom. I think all teenage kids may. Male and female need to get that back saying before they become sexually active because we can completely present that disease. Now, the normal cancer catcher that we're talking about here melanoma and stuff like that. It's just so hard to predict who's going to respond and. What the targets are immune system just attacks stuff. In almost every case is different. There are some hereditary cancers, though, might be able to vaccinate people to really give serious consideration already have some lesions that may predispose the then we could take care of that. Jim is it is it that the we have one word to describe all of these kinds of cancers. So we think of them as one monolithic target to attack. But maybe we need different words for them. All so that we can think of them as things that were respond to their own unique solutions. Right. I mean, it used to be it was cancer. Then we realized we I'm speaking for the whole field. People realize that you know, there's skin cancers breast cancers, code caches..

cancer FDA kidney cancer food Drug administration Ed Dallas Hodgkin Alaska H P Kyle Ryan Toth Jim Chuck Beverly I fifty percent sixty percent ten years
"jim allison" Discussed on StarTalk Radio

StarTalk Radio

02:19 min | 2 years ago

"jim allison" Discussed on StarTalk Radio

"He said I found a molecule. All the time. It's an sponsor while you look at. So when we see these commercials on television that say this is not a video game. This is not a screen saver. This is an actual cancer cell being attacked by your own immune system is that your research that the referring to. Wow. That is really proud now. Now, you only impressed because it was in a commercial because anybody just won the Nobel prize winner. No. But not everybody could get a commercial TV. That's true. I'm interested because I I'm I'm familiar with your work because my mother was lost to cancer last year about a week ago last year. I lost my mom to cancer bone cancer. And so but the immunotherapy was a little too. She was too advanced and too old. They said, so what are the cancers where your discoveries are most effective? Up to now, the most effective what has been melanoma about twenty metastatic melanoma, which when we started working on this. There was no approved treatment and been no jug that to had ever improve survival in randomised trial. There was no successful treatment. And so that was where the child with started. We started by when I was lucky it worked against all kinds of catcher, but started Melva, and what we know now that in approved by the FDA two thousand eleven after a lot of trials what we know now actually about two years ago. There was enough data DEP ten years. Follow data on five thousand people who've been treated in twenty something percent over twenty percent or alive ten years after a single round of treatment. And so when you add a second drug to drug subsequently discovered..

metastatic melanoma Nobel prize FDA Melva ten years twenty percent two years
"jim allison" Discussed on StarTalk Radio

StarTalk Radio

03:52 min | 2 years ago

"jim allison" Discussed on StarTalk Radio

"Skyping into us from where? Office to catch. Huston the cancer center in Houston, huge medical complex there. If I if memory serves, and you would just like minutes ago, awarded the two thousand eighteen Nobel prize in physiology and medicine and your professor and chair at the department of immunology at the university of Texas at the MD Anderson Cancer Center, did I get all those all those titles. Correct. That's correct. Excellent. So did they call you in the middle of the night and said, you win the Nobel prize, and you hung up because you thought it was a prank call because that's how it happened for me. No, actually, there's been some buzz last couple of years and. And my wife says, well, don't we wake up the clocks founded ring? So this next year. Okay. This year, I got up and said the phone I guess next year. In writing. I guess we're gonna make sure the phone rang at that instant was my son. I just saw TV Nobel prize. And I said really what? And then. And then found there was call from Sweden on it. Basically. Peter you found out like through the news, basically, not from the actual Nobel. Right. So number something. I don't know. See I've never gotten to know about price because my phone number's unlisted. Better fix that. So again, thanks for. I know you must be swamped with media inquiries, and and the likes. I'm delighted that you gave this program this hour of your time. So thanks for that. So if you could just lead off by telling us, what is it that you were recognized for doing? I was reading dice for developing away to get the system to attack cancer cells, which is something that, you know, people doing for time, and and it's potentially curative in many cuts cancer. So instead of attacking the tumor, which would be the natural. I thought right 'cause that's bad. Let's get rid of it. Let's attack it you you came in the back door. Yeah. What we did. For three decades. I've been trying to understand how these cells called T-cells, the kind of the warriors immune system, all of your body at tricked virus-infected seller tumor or something then I deal with it. When I use it killing. Anyway, we know they could attack doing the us tumor cells. But Gilliam effectively was easy. A lot tries fail to try to you know, arm to attack the cancer or getting. But found a molecule called CT LA Ford matter when for but is a molecule is sort of breaks of immune system after T cells get going use this as a negative regulator turned himself off. So they don't hurt you by just continuing to divide divide divide y'all with Coyote, sell it. So the idea that maybe. Normally that molecule the brakes coming onto earlier stopping details. Limiting the cancer. So I thought well, let's just say disable the brakes temporarily and sure enough it works. But just just for the reason you're said a lot of people had real cello with because I said, you know, how could you she cancer back during the catcher, you're not even treating the cancer. You're treating them system. Not. Not. You started your answer..

Nobel prize MD Anderson Cancer Center professor and chair Huston Gilliam Houston university of Texas Sweden Peter Coyote three decades
"jim allison" Discussed on On Point with Tom Ashbrook | Podcasts

On Point with Tom Ashbrook | Podcasts

02:46 min | 2 years ago

"jim allison" Discussed on On Point with Tom Ashbrook | Podcasts

"University in Japan. And Jim Allison is the chair of the department of immunology at MD cancer center. And Jim Allison, welcome to on point. Grubby here Magna at first of all, hearty congratulations to you. What does it feel like to be now be known worldwide as Nobel prize winning researcher? Jim Allison stood out of seeking in to tell you the truth. It's just been who are wind bacteria since the now's was made over week ago. Yeah, I, I can imagine that it's been a very busy time for you, but but I understand that just sort of anecdotally, you found out that you'd won the Nobel prize, not from the Nobel committee itself. Our our, you informed. Well, I, I got up in the morning really, really early and. Kind of thinking that wasn't going to happen because there'd been a lot of buzz the week before might my wife said, well, look like it's going to be next year and you know, because it had phone run yet in rang it was my son said, dad, dad you on. And then then at my phone said, there's another call from Sweden. So I said, I gotta go. There's another Sweden. Yeah, they had. They had some Trump. I don't know. They didn't have my phone numbers. It's interesting, the state age, the Nobel committee. Sometimes that's trouble reaching out to people who who they have, they've deemed have changed the world here. Now you mentioned your wife. I should mention her as she's, she's a, she's a researcher with you in these cancer. Immunotherapy is right pod Sharma, right? Just we worked together and she's a genital, urinary oncologist hear him to Anderson it together. We went to group called therapy platform where we're trying to really understand the impact of these new jugs on on the immune system and how they interact with each other and trying to optimize the treatments to make more effective for more people. Okay. Well, so let's talk a little bit than about about the actual research itself. When we say cancer immunotherapy, I mean sort of give us the the biology one. Oh, one explanation of that. What are we talking about? Well, there actually several John's of immunotherapy away from growing Kanter specific cells called t. Cells that are actually the soldiers of the system. You know, you can grow them up in large numbers, taken from patient grom up, get the right kind put them back in the what I developed. This was a little bit different. I'm really basic immunologist at hard and have been working on t. cells ever since I found out about him in late sixties and trying to figure out how they work and amazingly complex..

Jim Allison researcher Nobel prize Nobel committee Sweden MD cancer center Japan Trump pod Sharma Kanter John Anderson
"jim allison" Discussed on BizTalk Radio

BizTalk Radio

02:49 min | 2 years ago

"jim allison" Discussed on BizTalk Radio

"American ensuring the Nobel prize for medicine USA radio networks, Chris Barnes has more on the story to scientists run from the US and one from Japan are the winners of the Nobel prize for medicine, the Nobel Institute in Stockholm announcing the Jim Allison and to sue Honjo were honoured for their discoveries leading to new approaches and using the immune system to battle cancer. Allison is a professor at the university of Texas MD Anderson Cancer Center in

md university of texas professor usa houston stockholm nobel prize america japan today augusta
Houston scientist Jim Allison awarded Nobel Prize for Medicine

Investor's Edge

02:49 min | 2 years ago

Houston scientist Jim Allison awarded Nobel Prize for Medicine

"American ensuring the Nobel prize for medicine USA radio networks, Chris Barnes has more on the story to scientists run from the US and one from Japan are the winners of the Nobel prize for medicine, the Nobel Institute in Stockholm announcing the Jim Allison and to sue Honjo were honoured for their discoveries leading to new approaches and using the immune system to battle cancer. Allison is a professor at the university of Texas MD Anderson Cancer Center in

Nobel Prize Jim Allison Nobel Institute Anderson Cancer Center Sue Honjo Chris Barnes United States Stockholm Professor University Of Texas Japan
"jim allison" Discussed on KCBS All News

KCBS All News

01:35 min | 2 years ago

"jim allison" Discussed on KCBS All News

"Be grabbing a ride through casual carpool. Then he says when there's slightly more traffic he doesn't notice because he's not the driver waiting for carpool. Usually takes a long time. Anyway, so. It hasn't affected me. Just a normal day. Of course, it could as the week wears on. If the carpool drivers decide to take Bart or work from home because of the effects on the morning commute the morning the rubber situation because the Fremont street exit closure blocks major entry point to downtown for those coming in from the East Bay in downtown San Francisco, Megan gold, speak KCBS bump had a bar had a bump and ridership today, albeit a small one about four percent Jim Allison said they were prepared for the increase in ridership. But for a completely different reason we planned for the dream force week. I getting ready all of the cars that we could. So even before the situation with the transbay terminal we had planned to run as many cars as we could on our trains that are heading across the bay. And so far it seems to be working out pretty well. Barreds? Jim Allison moms and children across the country rallied today to demand the Wells Fargo and chase stop financing immigration detention centres were separated families are being held KCBS. Carrie Hodousek spoke to protesters outside Wells Fargo headquarters in San Francisco. There are thousands of people across the country that are handing over petitions to ask Wells Fargo and chase to stop financing private prison says organizer or Lisa Batista, signed on.

Wells Fargo Jim Allison San Francisco East Bay Lisa Batista Carrie Hodousek Megan gold Bart four percent