17 Burst results for "Howard Florey"

"howard florey" Discussed on The Science Show

The Science Show

03:32 min | 4 months ago

"howard florey" Discussed on The Science Show

"Out but at <Speech_Music_Male> and with penicillin <Speech_Music_Male> the first time <Speech_Music_Male> a human being and <Speech_Music_Male> being treated <Speech_Male> <Advertisement> with the new antibiotic <Speech_Music_Male> drug flory <Speech_Male> had <SpeakerChange> cut <Speech_Male> discovered flory <Speech_Male> went on to share <Speech_Male> the nobel prize <Speech_Male> with two of his fellow. <Speech_Male> Researchers in nineteen <Silence> <SpeakerChange> forty-five. <Speech_Female> <Speech_Female> No minister <Speech_Female> flurry did not <Speech_Female> share the nobel <Speech_Female> prize with two <Speech_Female> fellow researchers. <Speech_Female> <Speech_Female> He shared it with one <Speech_Female> fellow researcher <Speech_Female> and chain <Speech_Female> and <Speech_Female> alexander fleming <Speech_Female> with whom he <Silence> never worked <Speech_Female> <SpeakerChange> howard <Speech_Male> florey <Speech_Male> emphasized <Speech_Male> of <Speech_Male> all. We didn't look with <Speech_Male> sir alexander <Speech_Male> fleming. I hardly <Speech_Male> knew him. <Speech_Male> What was done <Speech_Male> ten years <Speech_Male> before the wick auction <Speech_Male> <Speech_Male> that we just happened <Speech_Male> to look on the substance <Speech_Male> that <SpeakerChange> he discovered <Speech_Female> <Speech_Female> the nineteen forty-five <Speech_Female> nobel <Speech_Female> prize for physiology <Speech_Female> and medicine <Speech_Female> was to be <Speech_Female> awarded for the introduction <Speech_Female> of the drug <Speech_Female> and the story <Speech_Female> goes was <Speech_Female> very nearly <Speech_Female> given to alexander <Speech_Female> fleming alone. <Speech_Female> So great <Speech_Female> was the public <Speech_Female> perception that he <Speech_Female> and only <Speech_Female> he was responsible <Silence> for it. <Speech_Female> In the <Speech_Female> end it was shared <Speech_Female> equally between <Speech_Female> fleming flory <Silence> and chain <Speech_Female> <Speech_Female> but even <Speech_Female> as penicillin was <Speech_Female> being hailed as <Speech_Female> the miracle. <Speech_Female> Drug reports <Speech_Female> began <Speech_Female> trickling in of patients. <Speech_Female> Failing to <Speech_Female> respond to treatment <Speech_Female> of allergic <Speech_Female> reactions <Speech_Female> and improper <Speech_Female> use <Speech_Female> alexander <Speech_Female> fleming was flourishing <Speech_Female> in his newfound <Speech_Female> career of acknowledging <Speech_Female> public <Speech_Female> gratitude. <Speech_Female> Even so <Speech_Female> he just <Speech_Female> like flurry <Speech_Female> had some <SpeakerChange> grave <Silence> concerns <Speech_Male> over <Speech_Male> fear. The twin penicillin <Speech_Male> can be <Speech_Male> bought. Over-the-counter <Speech_Male> patients <Speech_Male> will indulge <Speech_Male> in self medication <Speech_Male> and <Speech_Male> in many cases they <Speech_Male> will not take <Speech_Male> large enough doses <Speech_Male> the doses through <Speech_Male> small the <Speech_Male> microbes. All not cured. <Speech_Male> And there's <Speech_Male> a danger that <Speech_Male> there will be educated <Speech_Male> to his this <Speech_Male> <Speech_Male> once. A microbe <Speech_Male> is being educated <Speech_Male> to <Speech_Male> assist the. <Speech_Male> It does not <Speech_Male> lose this property. <Speech_Male> They quickly <Speech_Male> we might <Speech_Male> then of someone <Speech_Male> who has a simple <Speech_Male> sore throat. <Speech_Male> Taking himself inadequate <Speech_Male> way with <Speech_Male> penicillin <Speech_Male> and educating <Speech_Male> microbes to visit <Speech_Male> <Speech_Male> these educated microbes <Speech_Male> could then <Speech_Male> be passed on to his <Speech_Male> best friend <Speech_Male> might get pneumonia <Speech_Male> for which <Speech_Male> the microbes <Speech_Male> being now penicillin. <Speech_Male> <Speech_Male> Venezuelan would do <Speech_Male> no good <Speech_Male> here the first <Speech_Male> man by thoughtless <Speech_Male> use of finished <Speech_Male> suing been malware <Speech_Male> responsible <Speech_Male> for <SpeakerChange> the death of <Speech_Female> his best friend <Speech_Female> in one of his last <Speech_Female> interviews in the <Speech_Female> late nineteen sixties. <Speech_Female> Howard <Speech_Female> flurry sounded <Speech_Female> almost despondent <Speech_Female> about <SpeakerChange> penicillin. <Speech_Male> <Speech_Male> Occasionally all <Speech_Male> <Speech_Male> that works <Speech_Male> but then you got to see <Speech_Male> the reverse side <Speech_Male> of the medal. Because <Speech_Male> i'm not <Speech_Male> accused of being <Speech_Male> partly responsible <Speech_Male> for the population <Speech_Male> explosion <Speech_Male> which is one of the <Speech_Male> most devastating <Speech_Male> thing <Speech_Male> well has <Speech_Male> got face <SpeakerChange> for the <Speech_Female> rest of this century <Speech_Female> in one thousand <Speech_Female> nine hundred sixty five <Speech_Female> flory was <Speech_Female> made baron <Speech_Music_Female> lord flurry <Speech_Music_Female> of adelaide <SpeakerChange> and masten <Music> <Music> <Music> <Music> <Music> <Music> <Music> <Music> <Speech_Music_Male> <SpeakerChange> <Speech_Music_Male> <Speech_Male> a story <Speech_Male> for australia day. <Speech_Male> Perhaps a <Speech_Male> nation that spans <Speech_Male> the gamut from jerry <Speech_Male> jones to <Speech_Male> best mckenzie in from <Speech_Male> paul keating <Speech_Male> to polling <Speech_Male> hanson could. <Speech_Male> Do well to remember. <Speech_Male> It's true <Speech_Male> heroes. <Speech_Male> That's the final <Speech_Music_Male> in this sanchez <Speech_Music_Male> series of profiles <Speech_Music_Male> by sharon <Speech_Music_Male> carton. <Speech_Male> Next week we go <Speech_Music_Male> up inside the arctic <Speech_Male> circle <Speech_Male> production by <Speech_Male> david fisher an anne <Speech_Music_Male> marie de bettencourt. <SpeakerChange> <Speech_Music_Male> I'm robin williams. <Music>

marie de bettencourt david fisher robin williams sharon ten years Howard forty-five Next week one thousand nineteen two nine hundred sixty five nineteen sixties first time one nineteen forty-five hanson lord flurry first australia
"howard florey" Discussed on The Science Show

The Science Show

03:24 min | 4 months ago

"howard florey" Discussed on The Science Show

"Incapacitated <Speech_Music_Male> <Advertisement> <SpeakerChange> <Music> <Speech_Music_Female> <Speech_Female> <Silence> <Speech_Male> <SpeakerChange> patients <Speech_Music_Male> <Advertisement> today units <Music> <Advertisement> <Speech_Music_Male> <Advertisement> <Music> saga <Music> <Advertisement> <Music> <Advertisement> <Speech_Music_Female> <Advertisement> <Speech_Music_Female> in. And <Speech_Music_Female> <Music> <Advertisement> <Speech_Music_Male> <Advertisement> we <Music> <Advertisement> <Music> <Advertisement> get paid. <Speech_Music_Male> <Advertisement> <Speech_Music_Male> <Advertisement> Hear <Speech_Music_Male> <Advertisement> you show. <Speech_Music_Male> <Speech_Music_Male> <Speech_Music_Male> <Speech_Music_Male> <Advertisement> <Speech_Music_Female> <Advertisement> <SpeakerChange> <Speech_Music_Female> <Advertisement> <Speech_Female> I'm howard florey <Speech_Female> was busy <Speech_Female> than he'd ever been <Speech_Female> but in august <Speech_Female> nineteen forty <Speech_Female> two. That comes <Speech_Female> a twist <Speech_Female> when reality <Speech_Female> gives way to myth <Speech_Female> and myth <Speech_Female> becomes folklore <Speech_Female> when <Speech_Female> alexander <Speech_Female> fleming. Who went <Speech_Female> back to working on. His <Speech_Female> nose drips after <Speech_Female> his discovery of <Speech_Female> penicillin <Speech_Female> finds himself <Speech_Female> the centre of media. <Speech_Female> Attention <Speech_Female> left to <Speech_Female> fleming. We may not <Speech_Female> have the drug today <Speech_Female> and <Speech_Female> yet more often <Speech_Female> than not it is <Speech_Female> fleming who gets <Speech_Female> the credit for penicillin <Speech_Female> not flory. <Speech_Female> Why <Silence> how did this happen <Speech_Female> <Silence> then. <SpeakerChange> Had beco- <Speech_Male> alexander <Speech_Male> fleming <Speech_Male> head of distant <Speech_Male> cousin who <Speech_Male> was dying of <Speech_Male> bacterial <Speech_Male> meningitis <Speech_Male> and he <Speech_Male> tried <Speech_Male> for <Speech_Male> more <Speech_Male> than a week to cure <Speech_Male> it with self <Speech_Male> drugs. <Speech_Male> The so-called <Speech_Male> discover <Speech_Male> of penicillin <Speech_Male> had tried <Speech_Male> for week to <Speech_Male> save his friend's <Speech_Male> life with sulfur <Speech_Male> drugs <Speech_Male> and when <Speech_Male> he sold it. These fred <Speech_Male> was dying <Speech_Male> in penny. <Speech_Male> He telephone <Speech_Male> flory <Speech_Male> on a sunday <Speech_Male> morning <Speech_Male> in oxford <Speech_Male> begging <Speech_Male> for some penicillin. <Speech_Male> <Speech_Male> Flory <Speech_Male> came down <Speech_Male> to london <Speech_Male> <Speech_Male> and handed his <Speech_Male> whole supply <Speech_Male> of penicillin. <Speech_Male> Crystalline <Speech_Male> powder <Speech_Male> into <Speech_Male> fleming's <Speech_Male> hand and gave <Speech_Male> him instructions. <Speech_Male> How to use <Speech_Male> the doses. <Speech_Male> How to inject <Speech_Male> what to do. <Speech_Male> Fleming went <Speech_Male> back to bears <Speech_Male> and traces. <Speech_Male> His friend <Speech_Male> saved his life <Speech_Male> on. This was <Speech_Male> so wonderful <Speech_Male> like cold <Speech_Male> the press in to <Speech_Male> announce that they <Speech_Male> had this wonderful new <Speech_Male> drug <Speech_Male> and he was there <Speech_Male> ready in this <Speech_Male> white coat for his photograph <Speech_Male> to be taken <Speech_Male> and <Speech_Male> win. The price went <Speech_Male> up to oxford to <Speech_Male> get the other end of the <Speech_Male> story. Flurry <Speech_Male> refused to see <Speech_Male> them. So <Speech_Male> the man <Speech_Male> who was available <Speech_Male> for the media <Speech_Male> was the man they <Speech_Male> sought <Speech_Male> whereas people <Speech_Male> who did the work <Silence> were <SpeakerChange> not noticed. <Speech_Female> <Speech_Female> And why <Speech_Female> did flory send <Speech_Female> the news hounds <Speech_Female> packing <Speech_Female> because he <Speech_Female> knew that any <Speech_Female> publicity would create <Speech_Female> a huge <Speech_Female> public demand <Speech_Female> for penicillin. <Speech_Female> And there's simply wasn't <Speech_Female> any to be given. <Speech_Female> He <Speech_Female> believed it'd be immoral <Speech_Female> to raise <Speech_Female> hopes. Only <Silence> to dash them <Speech_Female> in <Speech_Female> the nineteen sixties. <Speech_Female> <Advertisement> Fleming and flurry <Speech_Female> <Advertisement> was still <Silence> interchangeable. <SpeakerChange> <Speech_Male> One <Speech_Male> hundred events <Speech_Male> that change the world <Speech_Male> first published <Speech_Male> nineteen sixty six <Speech_Male> enniskillen <Speech_Male> a victory <Speech_Male> over death <Speech_Male> from the day. The spall <Speech_Male> blue in through <Speech_Male> fleming's window <Speech_Male> he and others <Speech_Male> who believed in him <Speech_Male> never stop working <Speech_Male> on. The drug <Speech_Male> fleming was <Speech_Male> able to perform several <Speech_Male> minor but miraculous <Speech_Male> cures with <Speech_Male> the small quantities. <Speech_Male> He was <SpeakerChange> able to <Speech_Male> prepare <Speech_Female> remember. <Speech_Female> It's fleming they're <Speech_Female> talking about not <Speech_Female> flurry <Speech_Female> but even today. <Speech_Female> We still confusing. <Speech_Male> The flurry <SpeakerChange> fleming <Silence> roles. <Speech_Male> Federal <Speech_Male> health minister michael <Speech_Male> wooldridge officially <Speech_Male> launched the flurry. <Speech_Male> Centenary year <Speech_Male> in adelaide. This <Speech_Male> afternoon. <SpeakerChange> <Speech_Male> it's almost <Speech_Male> fifty seven years <Speech_Male> to the day <Speech_Male> when <Speech_Male> how it flurry treated <Speech_Music_Male>

"howard florey" Discussed on The Science Show

The Science Show

02:42 min | 4 months ago

"howard florey" Discussed on The Science Show

"Forty one pearl harbor. America joined the war so interest now meant the united states. Government considered penicillin of national importance. It took second place only to the manhattan project. Funds were found. The scientists peoria was certainly upping the yield but not enough to meet military demand. Never mind civilian needs. A new strain of the mold had to be found which would be more suitable for the deep fermentation processes that have been developed to increase production military personnel around the world collected handfuls of soil which were flown to peoria where the mold say contained were analyzed. Local peoria were asked to bring in every bit of mold. They could find the tea lady in the laboratory soon earned himself the nickname moldy mary because of her enthusiasm for collecting bits and pieces from rubbish bins owed salk soggy newspapers rotting food. One day she brought in decaying piece of rock mellon the mold on it produced the best penicillin of all three thousand times more than fleming's original mold they'd search the world over but the answer came from a moldy mellon right there in peoria soon. Us factories were making billions of units. Month they would be enough penicillin to meet the demand of allied casualties on d day. Howard florey and hugh cans. Who was the professor of surgery at oxford and a fellow rhodes scholar from adelaide flew to the north african battlezone where flory revolutionized. The treatment of war wounds biographer gwyn macfarlane miniature commanders in the field had been most impressed by the fact. One or two injections aniston cured case of gonorrhea like magic now. Southbound is that troops where in fact or dicamba with gonorrhea and they were due to take part in the invasion sisley. Nfl peeled for pennies. Shouldn't be used for restoring these men today. Units florida founded. This was really quite unacceptable. That penicillin should be used for scalawags with self inflicted wounds genuine battle casualties so poor referred the matter to churchill and charge or sent back a note saying this valuable drag must on no account be wasted. It must be used. The best advantage general pool interpreted this to mean that the best advantage was to use penicillin for storing. The gonorrhea.

One second place two injections hugh cans peoria America three thousand times today north african battlezone oxford Howard florey Forty one pearl harbor billions of units One day gwyn macfarlane florida adelaide united states rhodes
"howard florey" Discussed on The Science Show

The Science Show

06:23 min | 4 months ago

"howard florey" Discussed on The Science Show

"Night. The is filled with screaming goals and birds of death to hold german alcohol. Jomon bombs blew up. The locks retold the walker and dunkirk in loading pill times for the medical students at the done school. Like gus franco. One of my duties was to patrol around the done school of theology to protect the place against german parachutist related. Let's tin hat. A civilian gas mask and a wouldn't kudrow inscribed oxford university. Police aware of what they were doing in the trip that time. Certainly it was full of this chilling machines. Full of highly inflammable substances. My whole off the done school which cut lodge building became entirely. Converted into penicillin factor. Newman heatley a brilliant biochemist vital member of the oxford team records. The first groundbreaking experiments on mice eight mice were given a dose of a virulent streptococcus. Such a dose as would certainly kill them while naar later four of them were given penicillin and the other fall now owners controllers were given nothing sixteen and a half hours later the four controllers for dead but the enniskillen treated mice were alive and apparently quite well. Howard florey ernst chain norman. Heatley had the proof they needed. Chain apparently was almost dancing with delight and flurry well. He was as laconic as usual. But when he telephoned dr margaret jennings short time later. His excitement was obvious to her. When the professor rang me up on that sunday morning he expressed his feelings about the result of this experiment. By saying it looks like a miracle and as he was usually a person who was given to understatement. This was very surprising. The expression us meant that he was really excited about it. It's a take him some weeks to prepare enough penicillin for the mouse experiments. But flurry knew that a man is three thousand times the size of a mouse and if tests were ever to be carried out in man an enormous increase in production would be needed. The first difficulty was to obtain enough containers to grow the fungus in all kinds of lab class. Where president service as well as domestic things like is tends trays and namur bid pans. Bedpans were particularly good. But alas the into sixteen of them eventually affirm in the midlands offered to produce made-to-measure ceramic culture parts production increased a thousand times and soon there was enough for a human trial. A young doctor. Charles fletcher was to give the first injection of penicillin. Policeman who being in what is called. The septic ward a terrible for wall. We don't have now people with absences and balls and blames all them and this policeman was particularly bad ill. He'd had on his mouth about a month previously infection. It spread over his scalp had absences there to spread to build his is one of which had to be removed. He had absences being opened on off. He had absence of this lung. He was well on his way towards death on this total infection and we nothing to lose and everything to gain so we thought he'd have a try shortage of penicillin was such as off to the first day i collected all his. The school yard have been saved. And i took it in the battle over to the floor was working so that the penicillin convicts textured neo and used a gay in on the third day and when i got over that light focused flory was very taciturn. Mounir very man of few words and he was well. How's the patient chain was eastern european excitable. What's based like he's doing well and what that's marvelous and this lovely contests these two characters in charge of the work and every day. I did that on the third day. He was having the same venezuelans held on the first day. Fourth day he read. It was dramatically improved and he was sitting up in bed and his temperature. Come down but there was a dockside to the teams excitement. Flurry knew that the supplies of penicillin were running out. If the infection returned there was no drug. Left to fight it dr fletcher. I case was as well known tragedy because the supplies of penicillin ran out before the man was completely cured and he did impact dive the penicillin factory oxford couldn't hope to produce the necessary quantities of faster and cheaper way hat to be found. Norman heatley rory had tried to get british to make penicillin on a large scale but bombing was bad at this time and it was just not feasible. Therefore he took the bold step of going to america under the auspices of the rockefeller foundation trying to get american firms. Interested eventually yet. Another million to one chance. A friend of flurries suggested he visit an obscure little laboratory in the middle of the american wheat belt in peoria illinois. Their chemistry experimenting with agricultural waste products. One of the byproducts from turning corn into starch steep liquor and they decided to try growing the penicillin mold on this the mold love the new dot and increased its yield tenfold communicate of the pain. You don here. By over december nineteen.

Charles fletcher first injection two characters three thousand times Norman heatley rory Fourth day sixteen america million first difficulty december nineteen dr margaret jennings peoria illinois one chance third day sunday morning german One eastern european first day
"howard florey" Discussed on The Science Show

The Science Show

09:29 min | 4 months ago

"howard florey" Discussed on The Science Show

"In this sort of thing. We happen to hit an antibiotic which working man we could have worked with hundreds of others and they would have been chemical curiosities so this is a bit of luck. Howard florey was twenty three when he left adelaide to take up his rhodes scholarship at oxford. The year was nineteen twenty two as he made the long sea voyage to england as a ship's doctor quite unknown to him. A more experienced researcher by the name of alexander. Fleming was working on anti-bacterial substances in the departures of saint. Mary's hospital in london. One day they would share a nobel prize yet. They never worked together and we're never friends. Fleming was discovered penicillin and flory to develop it. Fleming was small neat and dandy with a mild scottish accent howard. Florey was tall. Had parted in the middle round national health spectacles and a chain smoker. If luck flurry says played a major part in the development of penicillin it was hugely important. In fleming's original discovery author leonard bickel. It was probably the greatest piece of serendipity. Medical history fleming went on holiday for two weeks and lift a petri dish with a culture of bacteria uncovered on his desk from somewhere. During that time a mode sports settled on that plate and begin to grow when he came back from holiday. This mode was about the size of a twenty cent coin and around it. The bacteria had died. He wasn't very very knows project. You just read in a bucket and a friend of professor hair. Who worked with him. Came in to talk about some subject. This deported out to have another look at it and he said that's interesting. How lucky can you get during fleming. Some break the weather was first cold. We've got the bacteria growing and then unusually warm which allowed the mall to flourish. And then if that wasn't chancy enough fleming put his petrie dish on top of a pile of others. In a tray of disinfectant ready to be cleaned being the top of the pile the telltale mode escaping washed away to oblivion by a matter of centimetres. The discovery wilson. As far as fleming was concerned that time he plunged it into a healthy rabbit and said it didn't hurt the rabbit but he didn't say that the queued diseases in the living system a nepalese greatest omission it would be more than a decade before its potential was recognized. We live in the post penicillin era. But what was it like. Before the age of antibiotics real. At the time the fleming found that mode on his plate the hospital infectious wards were crammed with people suffering from these diseases of pugh perreault. Fever scarlet fever. Many jarvis osteomyelitis heart disease infections and in new monia one. In three cases ended in the coffin howard florey was offered a scholarship at cambridge excelled and then went to the very young professor to sheffield university in nineteen thirty five years later he was appointed. Professor of pathology william done school at oxford. He was just thirty seven flory would lead and dominate that research school for the best part of the next thirty years. The late professor gwyn macfarlane is another flurry biographer. He first met flurry in nineteen thirty eight. Roy was a rough tough. Australian completely uncompromising other prickly very energetic and tenses coral spring and he brought to work this extraordinary dedication which was very infectious in such a way that he really could collect team of people who became almost dedicated and then susie is because himself despite his lavish the borrowed tree building. The william done school itself was demoralized under utilized and grossly under-financed from the start flurry had to fight for funds. And it was not a task. He relished this is part of a letter. He wrote to the medical research council. It seems to me that i have acquired a reputation of being some sort of academic highway rubber because i have to make such frequent applications for grants to crown the lot. I have just received from the university an intimation that they are contemplating cutting my grant on the grounds that a new heating plant will affect the economy on heating the building. You may gather that. I am fed up. Flurry needed money to do something unique. He wanted to build up an interdisciplinary team. He wanted chemists working with pathologists. He wanted bacteriologist with physiologists at times. He came close to breaking point over funding. For these stuff. Including that of dr margaret jennings gastroenterologist there despite the cash shortfall flurry still manage to attract top scientists around him. Not least ernst chain a highly excitable but brilliant biochemist as flurry himself recalled. Many years later came and work on penicillin but he came and worked on snake venoms but in the bergey at that time we were working on an antibacterial substance named liceu. I'm unchain became interested in the substance. And eventually he proposed. I agreed to go along with it that we made Saturday investigation antibacterial substances. And this was the start of my. We looked penicillin to ernst chain. This new to discover your. i mean. This is an individualistic. Outweigh the the general principle. Is that you out and you look for interesting biological phenomenon which you hope you will be able to exploit in chemical terms. Charring was reading fleming's old paper of fifty lines when he had a vision of a woman one of the ladies who worked to the done school walking along a corridor where the dish in a handle which a mode was growing and he went to see this lady and he said to this mode. I saw you was. She said yes he said what is it. She told him it was penicillin. Natale them the species of mode and he said that is the very mode fleming found in nineteen twenty eight. She said yes he culture tinny gave us a piece of it kept it alive ever. Since science is so full of pieces of serendipity choosing an obscure medical curiosity was one thing getting it financed quite another war was looming military needs took precedence over everything. Flurry approach the medical research council for funds yet again. The reply was prompt if not generous. He was awarded a whopping twenty five pounds to launch his project in frustration. He turned to the prestigious well. Funded rican rockefeller foundation. Which just about gave him what he wanted. For the first time in his career he was free of financial worries. But the work itself was never going to be easy. Unchain chemical properties of the substance of a most unpromising was described as unstable at. You lasted practically while you look at it but as leonard bickel looks back with all. The clarity of hindsight chain was extremely lucky. Charring took it on himself with a little amount of brown powder just enough to cover a fingernail and he pumped into a healthy rabbit and the rabbit survived. What he didn't know was that brown powder. Ninety nine percent was chemical rubbish. Only one percent was penicillin and he didn't know whether that ninety nine percent would contain anything that would be harmful to make the reputable or kill it. Flurry did not know about this test. Until after it was seen that it was successful done cook the spectacle is digits. Appalling inside the blazing line of a heterogeneous armata. French and british warships lay the volunteer flotilla of every district over these craft. Wheeled and swamped german. High bama's day and.

england gwyn macfarlane Howard florey two weeks Charring london leonard bickel Ninety nine percent twenty five pounds Fleming twenty three one percent fifty lines ninety nine percent british Roy nineteen thirty five years lat Saturday twenty cent oxford
"howard florey" Discussed on The Science Show

The Science Show

05:53 min | 4 months ago

"howard florey" Discussed on The Science Show

"Was appointed to the william don school of pathology at oxford university. It was here that the one of penicillin would be revealed and a new age of healing would begin but it would be wrong. To limit floor is scientific contributions to penicillin. He started the role of white cells in the fight against viruses and bacteria and he laid the foundation of our understanding vaccination today. He was fascinated as we discovered by his own mucus. Secretions in the gut and his published research forms a theoretical base for the outstanding work in western australia on helicobacter. Pylori remember the perth. Scientists also studied his own gut and gave himself stomach ulcers quite literally to prove to a skeptical world that were not caused by stress or smoking but by bacteria helicobacter pylori. It eventually changed. Stomach ulcer treatment the world over professor. Barry marshall we are using different kinds of penicillin to treat helicobacter so he wouldn't have that advantage if it wasn't for flurries discovery. It's interesting that in some is. The discovery of antibiotics penicillin might have put the dampening on helicobacter pylori. Because fifty years ago people were interested in bacteria in the stomach and they lost interest because there was so many other new discoveries in those days such as antibiotics penicillins and so we resurrected some of the old ideas and we can now look back at the literature and find reports of helicobacter. Pylori going back over hundred years by the time. Howard florey was only forty three. His basic research work had produced so many important papers that he was elected to the royal society the oldest and most famous scientific establishment in the world twenty years later flurry became its president the first pathologist and the first australian to do so dr. Dc martin was executive secretary of the society in the early days of his presidency. He told me that in making new proposals he must go carefully or one might hear the accusation. What's this bloodiest william. Bouch ranger think is up to floor want the society to stop canning publicly for more money and to do something about the scientists as explained in a letter. Scientists surfing portrayed as round shouldered mild people muttering incomprehensible words and hiding themselves in back rooms if they are young will be shown with dirty fingernails and of course if they wear a beard they will have an evil designs or they may be represented as superman who plucked out the secrets of nature by methods denied two ordinary homo sapiens. A forty three year old placement. It had been in hospital for two months. He was dying. A small saw the corner of his mouth caused by scratch from roy. Zone had become infected with to lazlo bacteria staphylococcus and strip to caucus. They bacteria spread through his buddy. His skin was covered in horrible oozing saws in his left eye had become so full of pass. It had to be removed on the twelfth. Throughout the year books including children's books have been written symposia held dramas produced internet sites established. Teaching kits distributed displays functions organized all under the auspices of the flurry centennary committee set up by the federal government. The committee spent most of the year promoting this australian scientific hero and encouraging young people to look up to our tool poppies georgia. Would you like to say something about what you understand by the tall poppy syndrome astray and how you think that might have. Pets affected flurries recognition in this country. Once he got penicillin out a intersection then blamed for the population explosion. Even though he'd save lives. Because i was living now so he got criticized for that. I don't think he's could really be classified as one because he's not exactly recognized. Monks too strenuous. I mean it's debatable. Whether he should be or not telling case should be awarded the status of being one of australia's most well-known paypal because he made a big leap in medicine Science teacher george catchpole in his year. Ten students at skaggs redlands in sydney penicillin came to the fore during wartime under extraordinary circumstances when bedpans had to be used to cultivate the mold when churchill was asked to decide to whom the precious substance should be given wounded soldiers or those with v d and when the wrong man were the mantle of the drug success leonard. Bickel memory of flory should be in the two hundred million antibiotic prescriptions that are written each year across the world of how many millions of lives. Those prescriptions saved. An i should say this that while he was totally averse and reluctant where a mantle of glory. Hey have protested that the suggestion that his life's work touch more people on this earth. Then did the teachings of jesus christ this is the science show presented by sharyn colton a portrait of.

sharyn colton two months jesus christ two hundred million fifty years ago george catchpole Barry marshall Howard florey sydney australia twelfth Ten students twenty years later western australia each year Dc martin first helicobacter pylori oxford university earth
"howard florey" Discussed on The Science Show

The Science Show

04:09 min | 4 months ago

"howard florey" Discussed on The Science Show

"Taken his cambridge in the late. Nineteen twenties and was offered a lectureship there in pathology when a boost time. A job fell vacant in adelaide. South australia came over a year or so later and a braided me not applying for an ice. It will ride. Didn't you offer to me piece. We don't do that well. The thing was quite different than i was offered. Something wrong. process said kevin lafferty. You've just stepped down as director of the john. Curtin medical school has your job being offered or are we still not doing that sort of thing. There was a search to get. Somebody said that they'd be someone in place. When i did step down and that essentially fell through and i think partly because it wasn't often why aren't we doing that sort of thing. Well you know there's still this feeling that everybody has to have their input and what usually finishes up at the end. Is you have a group of two or three on the shortlist. And then there's a lot of to and froing and they try and make a selection but some people will not go in for that sort of event and it's quite understandable if it's a fairly senior position and if you don't get the position sometimes that's considered as a bit of a black mark on your record. So people would much prefer the end that the position was offered and the opportunity came just after the war to assist in setting up university in canberra nineteen forty four. I was asked to ride memorandum on research. Australia twelve then prime minister mr curtain opportunities for people to do research. Were not very good and i virtually proposed. The setting up of an institute in which medical research could be encouraged. Would howard florey recognize his old junk curtain school. Do you think if he came back today volleyed raking us because this is the building he opened in nineteen fifty eight when i was here actually as a phd student because he with people like frank fenner designed the sexual building would he recognizes workings. What's happening here today. Flurry was the real role model for the school. It's a school that does basic science but does not lose the vision that that basic science must be taken to its. Clinical endpoint and florida was the one that showed us how to do that. So flurry was vital to the a anew and the establishment of the john curtin school. There's even a bust of him in the foyer there and a pretty comprehensive display of his life and work downstairs so you might expect the people who work there now particularly the students all of them postgraduates to know who in the world flurry was perhaps. Just a little something about his triumphant work with penicillin. Do you how it flurry was all s. She'd be honest. I do know that he worked here but a student here at john curtin scope mama. Phd's but you didn't know what howard florey did or what is associated with. Nah walk. Pass little display downstairs every day and influenced newest oakland raiders. Excuse me have you ever heard of howard florey. No i haven't this name. Howard flurry mean anything to you. You're a little bit sorry. Just do you associate howard florey within theme particular hundred. Jon gruden school. But yeah. I'm not really sure or are you a student here. Do you know who howard florey was. Sorry i know he he. Yes i do know him but i couldn't tell you he's last story. Do you associate howard florey with anything in particular penicillin of course. Have you ever heard of howard flooring on from city in one thousand nine thirty five howard. Florey.

frank fenner kevin lafferty canberra South australia three today twelve Florey prime minister Curtin medical school john curtin school Jon gruden school curtin two scope one thousand twenties adelaide nineteen forty four florida
"howard florey" Discussed on The Science Show

The Science Show

08:55 min | 4 months ago

"howard florey" Discussed on The Science Show

"Battles were raging. Most of the boys leaving some peter's going into the armed forces how it flory was turning eighteen shortly. His parents were bitterly opposed to him joining the war effort straight from school. His father's health and his businesses were failing howard himself had suffered from severe fictions his life besides he was their only son howard replied to these parental arguments in a letter to his father. The apollo i reckon. I ought to do something. Not because of a lot of boulder dash. That's talked about kickin country another patriotic rubbish. But because it's the right thing to do if chap stayed home and pleasantly followed his ordinary routine. What a fool he would feel when only chaps came back and he had a prolonged holiday in some very secluded knock. When i hear a chap saying he'd like to go to the war. I feel like calling him a liar or damned fool. I didn't want to go. But i ought to. And that's the whole position your affectionate some howard howard. Flurry didn't make it to the first world. War his parents refused consent. He was however to make a huge difference in terms of human suffering in the second world. War for now howard. Florey enters medical school at adelaide university and meets ethel. Read a fellow med student. Three years younger. She was to become his partner in an extraordinary scientific collaboration as well as in a far less successful marriage flurry never spoke publicly about his domestic life. Only his career and personal history. It was a small medical school in adelaide in twenty four from quite small number and a year. According to modern standards the teaching physiology was hardly less considering anatomy was quite good by chemistry. And how we started. There was no tremendous pressure on the adelaide course in those days very good and then i got a rhodes scholarship and went straight off to oxford. I think even in those days. I thought it was highly improbable that i'd come back to australia. And there's very odd thing to say. But i think i left here thinking that there were no opportunities solo things. I was beginning to get interested in physiology for example howard. Florey obtained his bachelor of science. And a i in the honors school in physiology at oxford. He may have left his birthplace with a hunch that he wouldn't return but he never stopped being australian as gus franco. One of his former pathology students at oxford remembers upper-crust at night for that was worth some pitas and everything that behaved like them. Proverbial steeliness understood. No that is to say. He never failed to call us. Bay the bloody shovel. He never kolin tie in the lab and he looks scruffy. Australians spent time in oxford had truly makes to say and lift up every inch of it. I was very well treated in oxford. One could get away with any sort of geisha regions by just one of these rough colonials. Good line play. But i fortunately selling with charles sherrington who was one of the great physiologist donated. Is david a little time. I was doing some research and changes department and one day. He came along and asked me if i was interested in experimental pathology. He said he saw time was ripe. For some body with a physiological background to take up some experiments in facility he then said. Would you like to get cambridge. Didn't he said that there's a student bay condemn i've been asked if there's anyone suitable hit put in for now. Put your name in. Despite being lonely at times he was never one to make close friends. Flurry explored the country when he could and sent his impressions back to earth. Oh i liked london amid slowly it just pulsating with life strolling in high park. I've been watching lately. Leaked riding and rotten row. I wonder if these people serve any useful purpose. I have infinite educational advantages but the main result is they don't eat soup with a knife. We're delightful close contorted a fair issue of rubbish florian. Death wrote to each other many times but hadn't actually met for five years when he asked her to join him in england. This seems to have been some doubt on both sides but they married almost at once. Leonard bickel the first reunion like was a little bit of discomfort. Because i think that he was little put out by how much she enjoyed the cellphone. The voyage drove but ironic is the fact that they were married together in a simple ceremony. Just a few yards away from where flaming to discover this critical vital mold on his little plate. That vital mode of course was penicillin but fleming never recognized its potential and did virtually nothing with it. Howard florey or decade or so later began work on this elusive little mold and in one thousand nine hundred forty five flory. His biochemist ernst chain and alexander. Fleming would share the nobel prize for physiology and medicine. Flory didn't start work on penicillin until just before the second world war but all his natural interests were preparing him for being the right man in the right place at the right time. Great discoveries often have their origins in the strangest beginnings professor. Gus franklin again now flinders university medical school haag troy extraordinarily like dope does and plagued with indigestion indigestion and analyze his stomach contents and he discovered he didn't have any acid in the stomach which is not too uncommon but it's associated with the nasty type of a name ya and cancelled the stomach and it was supposed to know that offer terrible teeth. Then the hard floor had well. Dude the used to swig high it to make up for the stomach didn't secrete anyway. He called fascinated with the whole problem of the lining of the stomach. And why he s. It doesn't avoidance on had got fascinated with body secretion generally and then fleming who also of course described the original peninsula played had discovered. That is an antibiotic in the secretion from your and my saliva knows which is called lines. Which is biologically very instinct. Because it turned attention away from chemical drugs to biologically created drugs could use by the human body. Oh by mode so animals and so flow. He worked on that and he needed to put by chemists to make progress and he wasn't by but then time by chemists in good supply because a lot of extremely chemists had been turned out of 'em they buy hit us so he planned to the home of fi chemistry in cambridge since he got a good one by chen who was also extremely disagreeable person but big tobacco florian chain set out to understand the actions of lies design which is a naturally occurring antibacterial substance. They then made a decision which was not regarded as i. The startling all significant at the time just a natural extension of their work to make a systematic and thorough. Study of all known natural antibacterial substances. One of these happened to be penicillin and the rest is they say is history. How wood floor is australian. Background tugged. tim always..

england charles sherrington Leonard bickel australia five years Gus franklin Three years Florey twenty four eighteen london both sides david second world second world war one thousand earth One Flory Fleming
"howard florey" Discussed on The Science Show

The Science Show

05:41 min | 4 months ago

"howard florey" Discussed on The Science Show

"Philip started showing symptoms friday night. We thought he was coming down with the flu. We had chills. Headache felt nauseous. Didn't want dinner saturday morning. I wake up. And i heard this funny moaning sound and i come downstairs and handlings. And he was just on the floor. I thought he was having a fetal a spasm or something because his head was thrown back in he was moaning and there was all vomit around his head and said l. Green the ambulance. Because i was trying. To call phillip. I was talking to him but he wasn't responding fourteen year old sydney schoolboy philip furlong who contracted manindra cockle septicemia. Before the discovery of penicillin. He would certainly have died today. Despite all the other antibiotics penicillin has spawned. Penicillin was still used as part of the arsenal of drugs. That saved him. His mother della furlong again then he was having trouble bleeding into his lungs and we thought he was going to go then because blood was just coming out was dripping. Ez's abbey's he's mouth and they had to call someone from theater to incubating and from then on if you just fought. His live awoke up in hospital and didn't know what's going on among those is saying all these things about the penalty lennon antibiotics ozone so. You bit thankful that we've got antibiotics today that we don't live in the era before penicillin. Howard walter flory. The man responsible for developing penicillin and ushering in the antibiotic age was born in one thousand nine hundred ninety eight. He and his oxford team of scientists turned the juice from a simple fungus into possibly the world's most powerful men. So robert menzies said that. Flory had more effect on the welfare of the world than any other howard. Flory i get much more credit than i deserve in this matter because i'm quite clear that nothing would have gone long except for group of about five or six people not a big group with some technicians and that was sufficient to discover all the essential points about penicillin a tape recorded by the national library with flory in nineteen sixty seven a lot of misconceptions about medical research. People sometimes think that. I and the others wick on penicillin because we were interested in suffering humanity. I didn't think you'd ever crossed our minds about suffering humanity. This was an interesting scientific exercise because it was some yutian. Mission is very gratifying. But this was not the reason that we started working on. Howard floor is interesting. Scientific exercises not only with penicillin although but certainly what he's best known for have had a profound effect on the quality of life for each and every one of us. He is one of the tallest puppies this country's produced you hit how much to most of us know about him. What his origins. Where did he come from south australia. Actually him flurry was born in a modest stone. Cottage in the adelaide. Suburb of moldovan. On september the twenty fourth eighteen ninety eight he was later rival and the only son of joseph and birth flory. His four older sisters doted on him intended to dress him. Like little lord fauntleroy with ringlets down to his shoulders. Joseph was the local shoemaker with a driving business ambition by the time how it was eight. His father was a rich man. He developed a range of footwear from working boots to dancing slippers and had factories across the continent. The family moved upmarket to a sandstone mansion. In the adelaide hills autumn leonard bickel has written extensively on howard flurry. He's met the man in person and your number of his friends and associates. The one person that i met who knew flory as a child was mrs molly. Bowen of adelaide. She was saying in herodotus but she remembered him as a tassell kid young boy full of life and vigor and they were rolling struggling through the greenfield's around their big home and he was very interested in life and in nature around him as she remembers him very clearly that he was a laughing happy young man when he was thirteen. Flurry became a day boy. It's peter's collegiate school in adelaide. The same school. That only years before had another nobel laureate to be lawrence bragg he of x ray crystallography fame. How a flurry came under the influence of the same inspiring chemistry teacher who had also supervised brags first experiments science teaching it. Peters was program quite good. We had a man named sneak at thompson. He was called sneak it because he used to go around and rubber soles shoes he used to get some chemistry into and quite an early age. I had some idea during research. I might have been twelve when came on but my sister saying. Oh you mean you'd like to be a sort of pasta and i didn't know what that meant. The i interest was chemistry. I was not very good at.

Philip philip furlong Joseph south australia thirteen friday night l. Green saturday morning phillip thompson september twelve Peters joseph today six people robert lawrence bragg first molly
"howard florey" Discussed on The Science Show

The Science Show

14:36 min | 1 year ago

"howard florey" Discussed on The Science Show

"You got in front of you there and he repairs itself. I hear these materials first and foremost are dead so these are not going to grow again but if you were to have a bioactive piece of material as long long as it's not a different species if you take to the light strain and put them together they'll actually grow infuse together over the course of just twenty four to forty eight hours and that bond strength drank achieved is comparable to that of the composite itself so rather than using border to grow your house together. You can just use the native culture and Mike Cowboys helping in this game well yeah. I think what's really interesting. You know we've been looking at Mike Otake show which is the meeting of my ceiling and architecture and I think what's really interesting. When it comes to particular bio brick is a whole range of performance capacities for the way that it is acoustic the way it's fire retardant? It's my feeling naturally hydrophobic. Ah Koy doesn't it actually I think is probably the opposite. It's probably totally queer. I would say it's very performance but then at the same time it's aesthetically very performance so you have these fantastic experiments that people done around the world various has precedence festival pavilions various experiments where because it's very strong but it's also very very lightweight and so you'll have interactive mobile installations where the audience can actually move it also win the buy a brick reaches its full colonization depending on the particular conditions in the particular particular substrate and species of my Caelian. It will in flower so you get these amazing. Mushroom flow is coming out so some artists and designers have have actually incorporated those two things one example is Phillip Roth from Michael Works is my co takes Alpha which was a tea house so he's got a tea house about route two and a half meters high. It's basically a self supporting arch bristling with mushrooms and then you can take one of those and water and then offer tatum audience so it's fun material functional one and if you remember that guy are involved in things like the wine industry the the beer industry alison why on Earth only one my college just beyond belief. I think funny just haven't been taught about unconsciousness. Strategy is perhaps for saying in the states or Europe or elsewhere. I mean we talk about flora and fauna wasted if with the fungus and I think it's amazing in this work that you guys are doing but I think I all scientific research is also driven by public interest in impetus and I think part of what I'm trying to do is get funding into our consciousness awareness awareness and actually have fung included in concepts of biodiversity get fungi species listed on our readiness read this equivalence and I think then government the departments the general public also people recognize. We actually made my college is to do this. Research will you've been detained us with the show and tell them you're on your tights. Could you show until with some of those but also describes him for those who are at home listening on the wireless and can't see them okay so I guess sort of trying to do is challenge the this kind of campaign stock star mushroom that we're familiar with in the supermarket because in Australia we've got this amazing diversity. Perhaps we could even say a mega diversity listen. You're fungi possibly one of the most diverse in the world because we've got all these different types of environments tropical ecosystems. We've got digits. We've got temperate rainforests and we've got things like this that don't look like your average mushroom then we've got things like this type of puffball and then we've got this particular one here which is known as a quarter sips which is actually delayed. Paris or fading on an insect and so we've got this amazing diversity. Some of the oldest fungal are the lichens every single agonising Kim by Isis and this whole notion of symbiosis for longtime was actually dispute in that time of Darwinian Nyein veteran alga underfunded songs together. There's sometimes Menagerie Twat eastern there as well and so these probably the first organisms as you mentioned earlier. This is amazing diversity. We you don't know how many species of Australia at the moment up to about fifteen thousand of the larger fung but that number could increase exponentially and most of them don't even yet have nine so a little research today still back in reading Brian do similar elite neglect the kingdom. I think it's fair to say that fungi or neglected all over the the world. There's a lot of really great information out there mostly from amateur. Mike adjusts in terms of the amount of science is done on fungi is relatively small small fraction compared to everything else and yet some of our most powerful antibacterial compounds come from fungi. Many of the ones that were still using in hospitals were developed from fungi so there's this huge range of things that fungi to and it's really exciting being in Australia for the first time because you have this immense diversity of fun guy. Does anybody know a better long as right what to eat truffles so you have marsupials that are living almost exclusively on truffles which are the fruit bodies of fungi that are below the ground and these fungi can no longer expel their own spores which is how other fungi disperse so. If you have a mushroom that's popping up. It's a fire outside. Spores wars and floats around these troubles are dependent on things like that's wrong and so on to eat their truffles and then spread their spores around this. They're moving around so not only does Australia have a huge diversity of fun. Guy Has a huge diversity of other organisms that depend on them and so you actually actually have all these symbiosis going on between plants and fungi animals and it's fascinating actually Westman strata they exploit the truffles they have and produce more for Europe than practically Europe does itself and they've worked out how to transport them very very quickly almost twenty four forty eight hours they they can be on the table in Italy or France now. I think you've heard Brian of a fellow who used to be at the university about K. Okay from here could Howard Florey penicillin no Tartan revolutionize the world and it still doing so in remarkable ways days finding new drugs to see how they can take on what sort of things going on do follow that well. I know that there are some people who are investigating the potential essential for fun guide to produce anti-cancer drugs. That's a big area of Biot- prospecting again. It's fun guy so there aren't actually all that many people looking Natta one of the people that I used to work with and British Columbia Keith Agar. He's got students who are looking into fungi with anticancer properties so it's a big potential area of research. We just need more people to be thinking about fun guy in the first place. Yeah I remember there was a dropped his university in New Jersey there it was a fellow who's working through a professor who was quite keen on finding a way of attacking to Berkeley losses and this guy went out student and he he dug up bits of earth and on the tenth attempt he found the active drug and there's a book about it which tells the story of sadly how the professor stole his idea got Nobel Prize no acknowledgement for the student in the soil looking for fun game looking for that sort of association still goes on given so principally what we look at is the mechanical properties of the tissue and things like yeast have been used for the production of Beer and fermentation technologies to small molecules for antibiotics and the like on what we think is really unique about filaments fungi is there naturally grown structure structure and how they can self assemble the structure in such a short period of time so for example if you take a look at a tree tree has amazing mechanical properties because it has this is beautiful vascular these long strands that give it its strength but unfortunately trees don't grow in the shape that we as humans typically require. They're not orthogonal correct tabular shapes so we tend to do is we take those trees we break them up into small particles and we glue them back together but when we do that we lose the inherent mechanical properties the mechanical properties degrade over two magnitudes when we do that so what's unique about fungi is that they can self assemble this molecular structure and they can do it in a rapid time scale and beacon can be grown to form and that's what's really unique about. Phil Mentors Fungi and what sets them apart across other types of life. Well going going back to launch system the story that I really loved that we put on the old catalyst couple of years ago. It was to do with preservation island ship. Call The Sydney the code of all things although it came from I think Calcutta they misunderstood how big the ship had to be bringing the Grog to Australia. They went down the west coast. They went along the bite and there were beginning to sink and they had virtual slaves from India who were dying. They they pumped out the suffering with trying to keep the boat afloat and eventually it got stranded on preservation island or what later became called. Best Straight and your museum in Launceston went out and preserved a major exhibition in part of that museum where I came across it they bought the the bottles in the bottles was yeast that had been there for two hundred years and they couldn't find a genome that matched so it had to have been there a long long time and apart from doing the science as usual scientists sort of an application making beer and they produced the world's eldest beer and there was argument not least from someone on this campus about whether it was really likely to survive so I did the obvious thing and took it to a guy got Nobel fries in yeasts and Paul Nurse at the Creek Institute in London I gave him some of the beer and he said there's no question that's great beer and the scandal and for two Hundred Years Amazingly so what else are you doing with fungi and Launceston thereabouts vouching Tasmania where incident combining it with different other biomaterials so I think what's really interesting with exciting about the way that it's colonized and a mold is is course in industrial sitting the still plastic in the equation because that's just is convenient for the process but we're interested in using yes I can help to form the mold willows hooding kelp in as the substrate for the my Caelian they had been experiments with using algae previously understand so it's really important. I think from local point of view both Kelp and my sealions tastes mania. We're seeing within the context of climate change as well and the name of the studio. Running is a clinic for solar stellar. Solar stelter is a term which is behind cygnus you feel when you're at home and the race of environmental distress. I in climate change. We've lost ninety percent of the Great Kelp forest because of the warming of the ocean. We've just had these incredible fires of twenty two thousand hickeys the condition of the environment there's an urgency there it requires imaginative and experimental and speculative responses because we really in the unknown with all of this and so having having these conversations across quite different areas and China connect the Filipino threads is really important see what might pop out of it. This is a sign show coming from Whoa madelayed the magic of mushrooms with Brian Pickles Michael Horn blow Dr Alison Polio and given MacIntyre the my CEO path to saving the planet and what about the future. What would you each like to see happen to exploit to further some of the interests the scientific interest because they fascinating things in themselves but also the application you just. What would you like to see happen? I we need more participants within the study of my college right now. Unfortunately are truly an endangered species and in terms of some of the most wild things that we're presently working on. We're all sitting down so I'll give you some background so one of the things that we're doing with pure since my Cillian is bio compatible. It's nontoxic you can't it is that we're actually starting to grow mammalian tissue on it. So one of the interesting things that we've been able to do is take biopsies from human cell lines incubate them on my Cillian and grow things like muscle and bone tissue directly on my Cillian for biomedical applications so we're able to use it as the structure draw for Human Oregon growth where if I need a new liver in ten years perhaps I can use to grow that particular product have you thought of combining it with the guys at the university and Melvin for that Matter Three D. printing them we haven't participated in Three D. Printing but we have partners both in the Netherlands as well as at the University of Texas is that have three printed my ceiling materials both for building construction as well as furniture applications and for organs they three d print ears in woollen. Go how interesting I'm not familiar with their work. We're working with the University of Ottawa Andrew pelling laboratory who is actually used apple scaffoldings to grow years in the past and now he's using my celine scaffoldings allison. What are the sky's the limit. I'm so excited that you're here. I mean this is so exciting. All these other Fungal freaks out uh but what I undo we have perhaps one of the greatest diversity is in the world of Funky but I think with potentially got the oldest knowledge of fungi we often look to Europe for that knowledge. We often hear that the Chilean's the Chinese have been using fungi of at six thousand seven thousand years but as is potentially sixty thousand as old bridge knowledge of fungi. He's potentially the oldest knowledge in the world soured love to see us actually recognize what we have a strategy and not just in terms of diversity but in terms of how much knowledge we have but that I as I said uh-huh early and requires greater public interest and awareness of how important they.

Australia Europe Brian Pickles Caelian Cillian Mike Otake Mike Cowboys Launceston Phillip Roth Biot Natta fung preservation island University of Ottawa tatum apple India Andrew pelling
"howard florey" Discussed on Curiosity Daily

Curiosity Daily

07:42 min | 1 year ago

"howard florey" Discussed on Curiosity Daily

"He's flurry and his team spent years trying to solve this problem testing the contents of soil samples from all over the world but none produced the mold they needed finally they conor break with some help from a bacteria logist named mary hunt. She'd been collecting moldy food. She found it bakeries and grocery stores than isolating the mold and the lab. The moldy winner ended up being a texas cantaloupe. That was perfectly ripe. Save for a small mold growth at its naval hunt even cut up the cantaloupe for the staff to eat and it was reportedly delicious us. The mold turned out to be the fungus penicillin crisis g._m. We're shielded two hundred times the penicillin fleming strain and once the fungus was exposed. I i x rays and later to you. The radiation it's production yields increased even more in one thousand nine forty-five the nobel prize in physiology or medicine was awarded to alexander zander fleming howard florey and ernst chain who is a biochemist who'd worked with flory on trying to reproduce this stuff. Most of us only remember fleming and that's mostly because of oxford offered universities p._r. Efforts and yes he should certainly be celebrated for his discovery but howard florey ernst chain norman heatley. Mary hunt and countless others were responsible for making penicillin a reliable practical drug that made it the greatest medical advances of the twentieth century very few advances come from only one the individual and this breakthrough was the definition of a team effort. Remember history isn't always as simple as it might seem and neither is science another thing thing that seems so simple but we have some drawbacks wireless charging. I hate to be the bearer of bad news but researchers say that wireless charging technology called inductive zip charging may be bad for your battery as reported by few charity inductive charging leads power source transmits energy across an air gap smartphones taken that energy gene with inductive charging coils. You'll find in newer devices especially in the last couple of years. You don't have to deal with cables when you do this but you do have to deal with potentially damaging heat that had charging pad can generate and that's part of the problem. The power receiving coil is usually close to the back cover of the phone which is usually electrically non-conductive. Thanks to packaging constraints. The phone's battery and power electronics are usually pretty close together so there's not much room to dissipate heat generated in the phone or to shield the phone from he comes from the charger. It's well documented that batteries age more quickly when they're exposed to higher temperatures so researchers researchers decided to conduct some experiments to see how inductive charging might affect a phone especially if it's not lined up correctly on the charging base that's because on a phone is poorly aligned and a wireless charger those inductive charging systems can increase their transmitter power or adjust their operating frequency that basically it means the charges less efficient and you end up generating more heat and it's actually pretty easy to miss a line your phone since the actual position of your phones receiving antenna isn't it's always obvious the researchers found that when a phone charged using a conventional cable the maximum temperature was never higher than twenty seven degrees celsius or eighty point and six degrees fahrenheit when the phone used inductive charging even when it was properly aligned its peak temperature was roughly ten percent higher at thirty point point five degrees celsius or eighty six point nine degrees fahrenheit that temperature didn't get much higher when the phone was misaligned but the peak temperature was reached sooner and and lasted more than twice as long. This isn't all bad news. The researchers noted that using ultra thin coils higher frequencies and making some other improvements could help alleviate this problem as this technology continues to develop for now inductive charging me be convenience but it'll probably reduce the life of your mobile phone battery. If that's the price you willing willing to pay for the convenience then go for it but if you want your phone to live its longest life then maybe stick to the cable. There's something to be said for being old school. Sometimes the alpha dog is a canine myth certain t._v. Dog trainers have made careers out of telling us that dogs will only respect your authority if they see you as the <music> alpha or dominating pack leader but this so-called alpha dog theory just isn't true what you're really needs. According to most animal behaviorists is reinforcement enforcement consistency and love the concept of alpha wolf originated with animal behaviorist rudolph schinkel who spent the nineteen thirties and forties studying studying the social interaction of wolves at the basal zoo in switzerland. His findings showed the group naturally competed for status until a male and female emerged as dominant in the pack but we now know that his entire paper was based on a faulty premise the idea that a bunch of unrelated animals brought together in captivity would behave the same way they would in the wild it would be like trying to learn about average human family dynamics by studying humans in refugee camps according to new research wild wolves actually live even family units that are strikingly similar to those of humans the parents guide the family's activities and split the chores of feeding pup rearing and protection and as the the pups get older their social status is based on birth order with the oldest of the top. This means so-called dominance training to change a dog's behavior is based on faulty science. It's even though they're used by celebrity. Trainers like cesar milan dominance tactics like mild quick smacks on the flank or pending dog on its back using an alpha role are ineffective at best. The american veterinary society of animal behavior has released a statement against the use of punishment modifying. Your pet's behavior and bonnie beaver the former president of the american veterinary medical association told time that they're on record as opposing some of the things cesar milan does instead most experts advise advised training that focuses on positive reinforcement in the end the risk of too. Many treats is much lower than a stressed insecure dog for we wrap up. I want to ask you to do us originally quick favor. It has been like a year since we asked for anybody to rate and review us on your favorite podcast app. It's not a thing that we're going to beg you to do every day but it'd be nice to see a a little boost and reviews once in a while just to help other people know at a glance that we're a good show and then we're worth listening to so if you're enjoying this then please distract us a quick rating in review and maybe we'll read your review on a future episode like this one from depan ville who says imagine hanging out with two youthful co workers or classmates who are excited to share things. They've just learned. I think that's a pretty good description and just last month. Sarah dear wrote. I love this podcast. I listen to it every day on my commute and it's very thought provoking. We are glad to provoke. Your thoughts asserted dear. I'm allowed to say that that's the username listed. It'd be rude. I don't wanna be overly familiar sarah or sara dear however you'd like to be addressed. Sarah darling's darlings. She said it not me. Thank you for writing that and for your feedback and yeah we're always happening here. The people are like in the show anyway now. Let's recap what we learned today today. We learned that we have penicillin. Thanks to more than a decade of research from lots of scientists not just one guy and that wireless charging might hurt your battery marib heating it up too much and the wild wolves actually operate like human families so you shouldn't try to teach dog otherwise but every cat is the alpha cat its own heart. You know how you address a cat right. Oh no you say it's not a dog cats the musical it's it's on tour join us again tomorrow to learn something new in just a few minutes. I'm cody. Gosh i'm ashley hamer. Stay curious on the westwood one podcast network..

penicillin mary hunt Sarah darling howard florey cesar milan texas conor nobel prize american veterinary society of fleming switzerland westwood one depan ville norman heatley ashley hamer rudolph schinkel flory bonnie beaver
"howard florey" Discussed on Curiosity Daily

Curiosity Daily

01:34 min | 1 year ago

"howard florey" Discussed on Curiosity Daily

"The true history of penicillin wireless wireless charging may be bad for your battery and why the alpha dog is a canine satisfy some curiosity. Do you know the real story of penicillin. Let's get into a little science history myth busting here's what you probably know in one thousand nine hundred eighty eight alexander fleming was growing bacteria in petri dishes in his lab ab when he noticed that one had started growing mold that mold had cleared a spot in the bacteria which suggested that it might have antibacterial properties fleming ming names the mold penicillin and became the world's first antibiotic it cured thousands of previously untreatable infections and spawned a new era of human health. That's the story anyway but while the first part is true the facts get hazy as the story goes on. Here's the problem with flemming's discovery. This strain of penicillin dennis ilia mold that he found camping out in his bacterial colonies was really hard to reproduce fleming and his assistance at saint mary's hospital tried for weeks to grow more of the stuff into isolate pure penicillin from the bacteria killing fluid that seeped out from the mold but they just ended up with a crew solution to work with still that was enough to demonstrate mistreat his findings and in one thousand nine hundred nine fleming published a paper about the molds antibacterial action but in the paper he only made a passing reference to penicillins potential intriguing infections. It was nearly a decade later in nineteen thirty eight when dr howard florey came across fleming's paper when studying the different ways that mold and bacteria can kill each other flurry.

penicillin alexander fleming dr howard florey flemming saint mary
"howard florey" Discussed on Miss Information: A Trivia Podcast

Miss Information: A Trivia Podcast

04:53 min | 2 years ago

"howard florey" Discussed on Miss Information: A Trivia Podcast

"Let's say blower. We're on the same wavelength. All right. I saw you struggling with this question. Number three. This verbose guy was friends with Muhammad Ali and famously repeated down goes Frazier during the build sunshine showdown in the boxing match between Joe Frazier and George Foreman name him. I don't know as Howard Cosell. I wasn't thinking of Howard's. Oh, yeah. They're Howard forgot every time when you have to quiz on famous Mary, Sarah. I don't remember. He was quoted as saying arrogant pompous of noxious Fain cruel verbose show off. I have been called all of these. Of course, I am. Question. Number four. The c m y que color model is a subtractive color model used in color, printing and refers to the four inks used can you name these four colors scien- magenta, yellow black perfect Siham CMYK model works by partially or entirely masking colors on a lighter usually white background, the ink reduces the light that would otherwise be reflected. Such a model is called subjective. Because subtract, the colors red green and blue from white light. White light minus red leaves Syon white light, minus Greenlees magenta and white light minus blue leaves yellow amazing. Very cool question. Number five ustralian pharmacologist Howard Florey won the Nobel prize physiology and medicine in nineteen Forty-five along with Alexander Fleming for his role and making a what bacteria killer that saved over eighty two million lives said penicillin it is penicillin he discovered accidentally in nineteen twenty eight as mold and his Petri dish, which he left unwashed during vacation. So being gross saved a lot of people. Remember that remember that don't wash your dishes, folks? No police do that. That's one of my pet peeves question. Number six. Piece is a color I dubbed in seventeen seventy eight and it was very popular color to wear the fashionable in nineteenth century. France is a reddish purple Brown color or a dark olive yellow. It is reddish Brown. It is reddish purple Brown. Puce comes from the French for flee in a said to be the color of bloodstains on linen or bedsheets even after being laundered from fleas droppings. Or after a flea has been crushed poops is also thumb. Okay. If he think about crushing a flea with your thumb postpone, who's suppose. Question number seven, which author and historian was probably still called last even though he wrote one of the most comprehensive books on American history appropriately titled a people's history of the United States, sit Howard zinn, it is Howard zinn. Thanks for that hit. No problem. He also wrote several plays and top political science and civil liberties at Boston University. He died in twenty ten. Question. Number eight color celadon is a gorgeous pale sea green color, but the name doesn't really describe it did the word celadon come from its chemical makeup the mineral that shares its color or character in a French novel. You didn't say a city in Pokemon game. Nope. But. Apparently, it's a city in a Pokemon and sell it on city. Look that up. I I'm gonna go with mineral it is actually character in a French novel lawns. You celadon was the name of a character who were green close in own Uva do phase seventeenth century novel, less three less lewd, less three house. L apostrophe S T R E E the three. I know I didn't know. Either. It was like the ashtray. Question number nine, the famously germophobic Howie Mandel created this TV show when choking on a piece of cake giving him the infamous voice of its titular character. What was this ninety nineties kids TV show? Oh, don't you know, don't you know, it's gonna be Bab world. Do you? Remember his full name. That's extra points. We'll just go, Bobby. What's his last name? Okay. He's sister was his brother was Derek. Yup. And his sister was like Kelly probably ninety. Throw me to tell you. Remember, it's Bobby generous. Generates generous. It's actually spelled generic, but it's pronounced generate. Elevated. I know I'm sorry. Oh, man. Deserved. Don't say that don't say that. I could not think of Sarah, I couldn't think of Sarah McLachlan the other day. So mad that you'll have much screaming. I didn't that up. It's a lot politics to everybody ice d- a lot episode. Okay. Question number ten, you know, I couldn't help my son..

Howard zinn Howard Sarah McLachlan Howard Cosell Bobby Joe Frazier Howard Florey Alexander Fleming Muhammad Ali Howie Mandel penicillin France Nobel prize Kelly George Foreman Boston University Fain United States Mary Derek
"howard florey" Discussed on Miss Information: A Trivia Podcast

Miss Information: A Trivia Podcast

05:57 min | 2 years ago

"howard florey" Discussed on Miss Information: A Trivia Podcast

"What a what a great actually with the revenue the revenue just doubled up his his costume for that. Yeah. The revenue is actually the sequel to the gator. It's amazing. So I have to give my gosh a name of my quiz to Steve. 'cause I was talking to it was like I'm going to Howard Hughes. Don't oh my quiz is going to be and he paused for like ten seconds. And then he goes. How about you do? Howard's and Hughes a quiz on famous Howard's and colors, and then he laughed. Oh, he laughed so much so rate. Thanks to Steve. This is my quiz on your has Howard's. Yes. My husband, Howard's and Hughes. Question. Number one. Archaeologist Howard Carter had the fine of his career in nineteen twenty two while in a dig in the desert with benefactor Lord Khun Arvin when he finally opened the case can Arvin asked. Can you see anything and Carter famously replied, yes, wonderful things? This discovery later created a craze amongst the fashionable in Europe, and the US what was it that he discovered? Question number two, which came first when it comes to orange the color name or the fruit name. Questionable three. This verbose guy was friends with Muhammad Ali famously repeated down goes Frazier during the build sunshine showdown in the boxing match between Joe Frazier and George Foreman name him. Question. Number four, the C M y que color model is a subtractive color model. Houston color, printing and refers to the four inks used can you name these four colors. Question. Number five Australian pharmacologist Howard Florey won the Nobel prize in physiology and medicine in nineteen Forty-five along with Alexander Fleming for his role in the making what bacteria killer that saved over eighty two million lives. Question. Number six puce is a color I dubbed in seventeen seventy eight and was very popular color to wear amongst the fashionable in the nineteenth century. France is a reddish purple Brown color or a dark olive yellow. Question number seven, which author and historian was probably still called last even though he wrote one of the most comprehensive books on American history appropriately titled a people's history of the United States. Question. Number eight, the color celadon is a gorgeous pale sea green color, but its name doesn't really describe. It. Did the word celadon come from a its chemical makeup. Be the mineral that shares its color or see a character in a French novel. Question. Number nine, the famously germophobic Howie Mandel created the TV show after choking on a piece of cake giving him the infamous voice of the titular character. What was this nineties kids TV show? And finally question number ten. You know, I couldn't help myself. I'm going to name five things, and you're going to tell me if it's a drag Queen or an official criolla crane color. I big Dipa ruby. Second eggs Benedict. Third mango Tango fourth Meatball, fifth jazz berry jam we'll give you a minute. Think about it. I'll be right back with answers Meatball? Meatball? Mr hughes. How are you? Trying to catch billions smile. All right here, we go. Let's do it. Let's do it question. Numero? Archaeologist Howard Carter had the fine of his career in nineteen twenty two while in a dig in the desert with benefactor Lord, Khun Arben when he finally opened the case Arvind asked can you see anything and Carter famously replied, yes, wonderful things this related created craze amongst the fashionable in Europe, and the US what was it that he discovered king Tut's to king Tut's tomb American. Egypt. Ah mania was sparked when Carter toward the US giving illustrated lectures during the nineteen thirties. He was not cursed by king Tut, instead dying unmistakably of Hodgkin's disease in nineteen thirty nine Lord Canan, though did die suddenly during the dig of blood poisoning in nineteen twenty three. Question number two, which came first when it comes to orange the color name or the fruit name. A. The fruit the fruit. Yes. According to studies the word, orange appears in the English language as early as the thirteenth century, referring to the great the color, orange was initially called jewelry, which is spelled it's beautiful. I know right. And it's even prettier it's old English. It's spelled G O L U H R E A D jewelry, which means yellow red on a related note. It is widely accepted that there is no single English word. That is true. Rhyme for orange, Hank. Blur ange..

Howard Hughes Howard Carter Howard United States Lord Khun Arvin Howard Florey Steve Europe Howie Mandel Joe Frazier Mr hughes Muhammad Ali Nobel prize Alexander Fleming Houston Lord Canan C M Egypt Khun Arben Hank
"howard florey" Discussed on Radio Free Nashville

Radio Free Nashville

02:20 min | 3 years ago

"howard florey" Discussed on Radio Free Nashville

"Nine the per capita income grew more than five five times in addition new protectionist slogans were adopted by south korean citizens for example it was viewed as a civic duty report anyone caught smoking foreign cigarettes all the money made from exports when developing industry south korean acted import bans high tariffs and excise taxes on thousands of products south korea's transformation was to quote chang as if haiti had turned into switzerland is transform asian was accomplished through protecting fledgling industries with high tariffs and subsidies and only by gradually opening itself to global competition in addition the government ran are heavily funded many larger industries at least until they were globally competitive the government ran a regulated the banks and therefore the credit controlled foreign exchange and used its currency reserves to import mature machinery and industrial products i'm not suggesting that latter part for the united states but the fact of the matter is that protecting your economy works and were basically the only developed country in the world that doesn't do it any longer rebooting the american games book this is the tom hartman program back tom hartmann here with you and i am super pleased and honored happy excited to have in the studio with me professor richard silberstein he is the founder of neuro insight at the moment he is professor emeritus of neuroscience at the brain sciences institute at swinburne university in australia where he served as the founding director he was previously the head of the department of physics at that university he was the head of the department of physics swinburne from eighty five eighty nine foundation director the brain science institute at swinburne honor a senior principal research fellow at the howard florey institute of medical physiology serves on the executive board of the international society for brain electromagnetic departure and the pan pacific conference for brain topography as well as the editor aerial board of brain topography is a long standing interest in functional brain imaging he is the inventor of something called steady state topography technique for mapping rapid changes in human brain activity professor silvers stein it is wonderful having you with us thank you very much tom.

editor executive howard florey institute of med principal australia richard silberstein tom hartman korea haiti research fellow director founding director swinburne university founder professor united states switzerland
"howard florey" Discussed on Sawbones: A Marital Tour of Misguided Medicine

Sawbones: A Marital Tour of Misguided Medicine

02:02 min | 3 years ago

"howard florey" Discussed on Sawbones: A Marital Tour of Misguided Medicine

"Doesn't seem like a smart idea um so that is what took a long time was to take that mold and isolate what is the compound in here that will help us treat infections and how can we do that just because something worked in a petri dish doesn't always mean it will work in the human body and even if it will making that happen is a that's a big process sleight of research goes into that so it took a long time it actually wasn't until 1940's to now we've jumped from 1928 to nineteen forty dead he was doing this research and he was publishing and another scientists dr howard florey who was a professor pathology at oxford university got really excited about it and said you know i think we can help with us so him and hit and another biochemist that he worked with dr ernst chain started working on this process how can we make more of this mold and isolate what in it will treat nina will kill the staff so the problem that and they they were very successful in doing this except that what they ran into is that it took them 2000 leaders of mold culture so they had to create two thousand leaders of this mold in the lab to isolate enough penicillin which was the key what that was what they call the compound that they found that inhibited the growth of bacteria to treat a single case of sepsis in a person uh that's a lot of mold lot annoyed to treat one person and they were having trouble overcoming that 'cause that what happened is they had this new thing they were using it in their lab in it seemed to work really well um and then there was a local case of a guy albert alexander who was a police constable who had been working in his rose garden when he nicked his face probably i'm assuming a thorn or something and he developed a really horrible say elitest from that infection of a skin and obsessed media big pocket of plus an infection under there he became septic he was dying and they were giving himself a drugs which were around at the time and.

oxford university dr ernst chain nina penicillin albert alexander dr howard florey professor
"howard florey" Discussed on The Science Show

The Science Show

01:38 min | 3 years ago

"howard florey" Discussed on The Science Show

"And it turns out that they do actually sleep one flew consolidated night so maybe a lot of this is cultural as well but certainly the clock defines that nighttime wendell as being the best for us to be asleep now you've won the l'oreal prize when was that wanted it mean to you i won that in 2015 eib is a grant will that is meant to be used in any flexible way that women in science would need to advance their careers in my case i used it to fund a sabbatical in switzerland to work with a professor called lee she blow who is one of the pioneers in the area of security and rhythms and i used it to spend a couple of months in his lab luntz some new techniques have lots of fun which are from family and all other commitments over here and just immerse myself in the science and that was great too rare privilege what l'oreal shy about the reasons that you got the award it's four two factors the first is to make sure that women in science have what they need to progress in in my case it was to be able to fund my development and i guess the second is to make sure that that is a pool of woman scientists out there who will make the future of science happen and equalise the playing field more and i guess i was lucky in that i was chosen to be one of these people not lucky just brilliant dr jug jugnauth working in the lab where howard florey cracked penicillin in oxford more from her shortly the l'oreal is mega and in a different way so his international goal day on the eleven th of october here's a schoolgirl admitted in america.

wendell eib switzerland professor lee luntz penicillin america howard florey