8 Burst results for "Genomic Science"
The Doctor's Farmacy with Mark Hyman, M.D.
"genomic science" Discussed on The Doctor's Farmacy with Mark Hyman, M.D.
"I'd love to hear about that. And doctor George church is the director of arpa, which is like darpa, but for health. It's like a deep science intelligence. And in age brain projects and the National Institute of health center for excellence in genomic science, he's co authored more than 625 papers, a 156 patent publications, one book called regenesis, and he's honors include Franklin Bauer laureate for achievement in science and time 100 most important people. And the election to the national academies of science and engineering. So welcome, George. Can I call you George? Thank you very generous introduction. Thank you. You know, as a functional medicine doctor, I focus on how do we optimize our biology and our health systems. And to really rethink disease completely. And I think that what you're talking about is a really different framework for understanding aging and disease from the traditional disease model. I mean, so most doctors are focused on the downstream diseases, but in terms of aging, it happens much higher up in the biological hierarchy. And so I'd like to sort of how we kind of can rethink our ability to approach healthy aging. What would the science is telling us now and sort of where we're headed and just love you to kind of riff on that for a while and then we'll kind of dive deep into some of your other work and thinking. Right, so different species of organisms live for different amounts of time. It's kind of programmed into our being mice live about two years in bowhead whales live about 200. And so that's one evidence that there's a program in there. It doesn't mean that it's immutable. It can be in principle it can be changed genetically for to a limited extent, epigenetically. We've improved our longevity worldwide on the order of once every four years. One year, every four years over the last 170 years, that's kind of steady progress. And we had a slight slowdown recently due to diet sedentary life, high medical costs, suicide backwards, and drugs. But we haven't really gone that far backwards. It's just a tiny little blip so far, but we need to be very cautious of it in no way have we gone back 170 years. But maybe we've gone back a year or two. So, but there's a lot of people that who wants activity is greatly affected by their not just their environment, but the genetics that they have. And we need to pay attention to them as well, not just the healthy. So looking at sort of the whole aging framework, you know, what are the top few things you can think of that are so important to actually prevent disease and just curious how you're thinking about it. Well, so I think a lot of the people that are listening and watching this podcast are already doing everything they can do. Maybe. I want to assume that. Exercise and watching your diet. Sleeping well, having good social interactions. These are these are all well known, at least. Whether it's convenient is another matter. But they will plateau at some level that's based on your genetics environmental components outside of your control and the genetics can include things that are species specific like being a human being. That doesn't mean that that's the absolute limit, however, because we have changed ourselves radically as a species. That's why we live almost twice as long. Now, through things like vaccines and. Public health, better diagnostics for cancer and better treatments. Yeah, so from some of the frame rate of the hallmarks of aging, this was something that's being talked about a lot in the halls of academia and research on aging. And there are things that happen to us as we age. It seemed to underlie all diseases, DNA. Damage, mitochondrial damage, trouble with proteins, inflammation, nutrient sensing problems, hormonal dysregulation, microbiome changes, epigenetic changes. And so, you know, there's 9, ten Howard found you slice them. Hallmarks, and there's a lot we're learning about how these phenomena that happen in our body actually are driving all these downstream diseases. And so the whole concept of aging is being challenged from just being a normal process to actually being a disease. And the WHO recently created a ICD 11 diagnostic category for aging. As a disease. And so can you speak to that concept of aging and disease versus just a normal phenomenon? And what we know about that and how I actually can start to treat aging well, I'm happy with it, however, is defined the ICD change is okay. But I think we could have and could still just treat it as a natural process that results in a series of age related diseases, and then we can get FDA approvals for interventions in that natural process. As it causes disease, as either preventative or rapid reversal of those diseases of aging. Almost every major source of morbidity and mortality, especially in industrialized nations, are due to either due to or greatly exacerbated by aging, even accidental death. Falling. The probability of falling down is higher and your probability of not getting up, probability of having bad outcome for an infectious disease also very steeply age related. So I think if we deal with the underlying causes of all these age related diseases, we can stay within the framework of disease without necessarily defining aging as such. To me, it's either way is fine, but we have been in our development of medicines focused on whatever the FDA considers acceptable. Yeah, well, but the interesting thing to me is that David Sinclair and other new talked about how if we treat the hallmarks of aging, we don't actually have to treat the diseases downstream. So we don't have to treat heart disease dementia, cancer, diabetes. They're all really one phenomena that manifests as different branches on a tree. But it's all the same trunk. And so how do we start to attack those things? Because traditional medicines take statins for your heart disease and do cancer screening and pretty much for dementia. There's no recommendation and maybe I'll be lifestyle. Diabetes obviously eat better.
WLS-AM 890
"genomic science" Discussed on WLS-AM 890
"Abortion really is Your take on that I think you're right Listen the images of these 5 beautiful children that were savagely killed in D.C. some of them old enough to be born alive You know these late term abortions as they call them but it's really a fantasy They were viewed by over 3 million people online just through live action feed When people see this whether they're pro choice or pro life they know this is a life This is a human being And their conscience is pricked Their heart is moved because we're humans As human beings we see if we're not totally blind We see the humanity in others And I think that's really what abortion is about It's about destroying the humanity in another person destroying them even though they're just as human as you are being when they deserve to live And I do agree with you I think when we live action we're reaching about 15 million people weekly with our pro life content And we see people changing their minds They might be saying they're pro choice but then they say oh I don't really abortion was really like that Or they have to think about it in a different paradigm They've been spoon fed This junk the garbage by whether it's the public school system or CNN or MSNBC that it's not a life you know abortion is just like a medical It's like getting your tooth removed But when you actually start learning about it you realize this is a human being with a beating heart that has value and abortion just violently destroys them And that women are not actually being advanced by this And I do think the tide is trading I've seen every day on social media My big change especially among young people which is who we reach Generation Z millennials when they learn about the horror their moved and they want to be opposed to abortion And finally Lila will not the final question but on this culture war topic I'm seeing politicians on the Republican side who listen I ran for office I didn't win but you know you talk to a thousand different insiders or whatever claiming some special knowledge about the process And I mean if I had a nickel for every time one of them told me oh stick with the tax cuts argument it's safe Stay away from the culture stuff You're running in Maryland I never did of course I ran on because I'm a conservative But we were terrified I heard it so many times like stay away from the stuff You're not seeing that now You're seeing Ron DeSantis in a red but slightly red if not purple state of Florida take the bull by the horns passing legislation this week banning the most horrible of these are all horrible but you're seeing it now where I think Republican politicians are hearing from people like you and me and the millions of listeners program and other programs who are saying you know what Yeah you know what That's right If we can't defend life it's kind of a meaningless movement They're stepping up around the country I think you're right Something is shifting And it's when people are brave enough to say the emperor has no clothes Say listen this doesn't make sense to be teaching our children about sex when they're three years old and having their teachers talking about their love life about whatever deviant sexual activity they're involved in or killing a baby when their heart is beating when they're human beings They deserve to live too It really is common sense And I think when everyday Americans stand up whether they have the massive platform you have down and the Pro Bowl voice you have or I stand up or anyone who's listening stands up and speaks the truth It really has a tremendous effect in emboldening others So say listen it's not so bad Yeah you take hits Yeah people get angry with you Yeah there's a cost But the more of us you do it the stronger we become And I see I'm seeing that happening on all kinds of issues and it's an exciting time because it's a big bad out there but I do think what you're seeing with governor desantis what you're seeing with some of these red or purple states where they're moving more towards red more towards conservative values is because enough everyday people are standing up and saying and that is enough I want this country to value life value marriage take care of our kids protect our kids and there's nothing more powerful than a mama bear and a popular who's woken up that I'm going to stand up for my kids Yes amen I keep saying Jim how many times do you say that on the show Jim do I produce He's not a his head We say that all the time Don't mess with mama bear Gosh you would have thought they would have learned that Virginia New Jersey Don't toy with the mom and get between the mom and the dad and the kids rely last question I'll let you go we're talking to Lila rose from live action also authored the book fighting for life You know I was inspired in church and Easter weekend I have a great pastor He's actually going to be on the show later And he just he does He's a warrior You know Christianity we were the original rebels I mean we just were against the Roman Empire initially We were the original rebels and it's so good to see priests now start to openly talk about the horrors of abortion You know I've been to church for a long time I don't remember the word being mentioned Some of the churches I went to And I was always kind of puzzled by that I mean if we can't defend life what's the point Now my God That might pass through he's great But I was having this conversation with the usher this weekend And I said it's important that we start to make this distinction even in religious institutions On politicking to note that there are people out there in politics who pretend what they're doing is secular this socialist Marxist collectivist nonsense the CRT pushers these partial bursts of both and pushers These are not secular people ila This is anti God stuff If the left can use that language then so can we This is anti God anti religion anti moral self There is nothing moral about abortion at any stage no less partial birth abortion And I think we need to talk about it that way I think you're I mean listen you're right Abortion has become a religious to the left Sexualizing children And make saying a boy needs can be a girl or girl can be this has become almost a religious ideology They have the passion of converts And we need to have the passion of the truth and say listen this is nonsense Protect our kids We're going to stand up for them And we need to believe as much as they do because look at the look at the progress that the left has made and the anti progress in the last ten years to devour really our kids and spread these dishes ideologies So we need to be proud of the truth that we stand by and we've mentioned Christianity Christianity was originally genomic science coming to the world He brought this value of the human person that he taught And that's when the Roman Empire started to change Infants no longer being left to die that was the common practice in the Roman Empire then the Christians would go rescue them right A Christians were the ones who think that slaves have value like their masters in Christ there is no slave or free There's just human beings that are disciples of Christ So we need to be proud of these values And this culture really needs them Our broken culture really has them And the more we can spread them the more we'll change this culture and bring it back to back to the truth and back to the valley of human life Yeah that's so that's so right That's so so well said Lila rose thank you from the bottom of my heart for your advocacy advocacy God knows how many lives people like you and your space and I know you don't take credit for yourself but have saved you guys are just doing amazing work Again if we can't defend life this whole conservative liberty based movement is worthless So thanks so much We really appreciate your time Thank you Dan Have a very blessed Easter enjoy it Thank you ma'am You as well That was Lila rose folks All through the book fighting for life someone I.
Masters of Scale with Reid Hoffman
"genomic science" Discussed on Masters of Scale with Reid Hoffman
"The first thing you're going to see a lot of colors. A huge big will and a elephants spinning up all on its nose and everything is children's sized that's the bryant co-founder of nightlife pediatrics. A chain of urgent care clinics in houston but this colorful waiting room and it's pint-sized furniture didn't see many patients during the pandemic. Thank goodness we already had telemedicine put in place. That was kind of our saving grace. Zoology had made the leap to telemedicine during a previous crisis a hurricane. What really got us going with. Telemedicine was harvey in twenty seventeen. If does hurricane if there is a winter freeze children's still get sick so even if they can't get to us physically we have to provide another way for them to get treatment. Is that kind of foresight to let night light. Whether the latest storm says an cave of capital one business one of the trends we see across business owners is an investment in continuous learning in continuous improvement. And so i think naturally when crisis hits that's an opportunity to think big think different because you have to once you start thinking who's to say where it'll stop. We'll hear how telemedicine gave zoology some big ideas of her own later in the show. It's all part of capital. One businesses look at entrepreneurs who are persevering with courage and innovation. I'm bob saffy. And i'm here with francis desouza. The ceo of alumina francis is coming to us from his home in san francisco. As i ask questions from my home in brooklyn francis. Thanks for joining us. Thanks for having me bob. So it's been quite a year for biotech. Genomic science gene sequencing highly effective cove in nineteen vaccines rolling out something. Aluminum has played a part in scrape. You're also in the midst of trying to reacquire a company. That was spun. Out of alumina grail. For about eight billion dollars. You face regulatory hurdles here in the us and in europe so many good things some challenging ones. I want to start with a general question. There's often a perspective for entrepreneurial leaders particularly out of silicon valley that in order to maintain innovation and to scale while challenging traditional models and institutions. That it's better to ask for forgiveness than to ask permission. The health and biotech arena is a little different. But how do you think about that idea of permission versus forgiveness in the way you drive toward innovation. I think there are some really important differences between healthcare and tech and primarily. One of the biggest differences is just a stakes right for what you do in healthcare. You are directly. Impacting the lives of people. And so we feel incredible sense of urgency. You can achy. Impact lies more quickly. Having said that you also want to move carefully and you want to make sure that you've done all the right things such that you know what you put in the market is actually helping and not hurting doing the work around the studies doing the work around the regulatory approval and then also the way healthcare is set up. You need to do work with the reimbursement entities to make sure that they have the data such that an innovation you bring to market is actually accessible to the community and reached by the communities that you intend to help and so we share the sense of urgency. But i think there's more work that gets done in healthcare before an innovation comes to marquette and rightfully so aluminum's worked successfully to get fda approval for various innovations and to get the payment systems. All in place. Now this deal with grail has put you in conflict with a different part of the government with the ftc. Federal trade commission as well as with european regulators. Can you explain to us how you find yourself in this situation. Aluminum for the first decade plus of our existence we used to sell genomic analysis tools into the research market and then in two thousand thirteen we entered clinical market for the first time through the acquisition of a company called nada. The did noninvasive prenatal testing now. The way grill started. Was we processing samples from pregnant mothers in our noninvasive prenatal testing lab and one of our scientists incredibly brilliant woman noticed that although the fetal dna in the blood was normal unhealthy. There was something unusual about the maternal dna. And so she alerted as we alerted the doctors to say look. Something seems to be off with the mothers here. And the doctor's got back to us and said no all fine but we'll stay in touch with them and see how they do and in all of those cases the mothers went on to find that they had cancer and didn't know it. And i remember clearly the meeting at aluminum. I still get goosebumps. When i think about it where we realized that we could be seeing these signals of cancer in a blood test and so we quickly put a team on it aluminum. This was in the two thousand fourteen to fifteen timeframe they worked for over a year and came back. And said yeah. It looks like we're seeing signals for cancer but there is a lot of work that needs to be done between where we are now and actually having a safe desk that we can bring to market we need to do some very large clinical studies and we need to home the test understand. What specifically are we looking for in the blood we knew that would take a huge investment. And so we spin out. The technology into a company called grail. We put over forty aluminum people integral and we raised ultimately over two billion dollars. And that's one of the reasons we wanted to spin it out to get access to the capital to move this technology as quickly as it could. The grill team worked for a few years. And in the fall of nineteen. They published their results and the test. They developed is truly extraordinary. This is a blood test that can identify fifty types of cancers across all stages now we know cancer kills ten million people a year around the world. Six hundred thousand here in the us alone. We also know that if you catch cancers early the patients have a much higher chance of survival in a lot of cancers. You'll see the odds of survival can get higher and up to ninety plus percent if you catch it in stage one or stage to the challenges that seventy one percent of people who die of cancer die to cancers that have no screen in fact forty five out of fifty cancers at grill screens for have no screened today like pancreatic cancer for example and so there's no ability to catch it early and so when grail published their data in the end of two thousand nineteen. We realized. This was a huge breakthrough and that this would save a lot of lives. And that's sort of how we initiated the process to acquire grail and what we wanna do is bring the grill test to market as fast as possible to people around the us and around the world. Grail has a terrific -nology alumina. We have the commercial presence in over one hundred and forty countries around the world. We have the teams that can work on reimbursement and regulatory approval and so we can dramatically accelerate getting this test into the hands of people whose lives it could save. And so the ftc's argument though is that by bringing grail back to being part of alumina that somehow there may be other efforts in this area. That will be competitively disadvantaged grail. We'll have an advantage over others doing research in this area. Do i understand that right. Yeah so the. Ftc has actually in the last forty years. Never been able to successfully challenge vertical merger so of companies buying another company. That's not an base. What the ftc is saying. Is that by us. Getting into this space we will reduce innovation in the cancer screening space and that we will have an incentive to raise prices of sequencing for other players. Now that's just fundamentally not correct because there are no other players grill..
Double Tap Canada
"genomic science" Discussed on Double Tap Canada
"Are adequately entertained while we follow asleep in our coffins martigues. The show a louder than i do because i just hung up in them located right. Let's do this the and marcus to do some. Cd's what by the magic. How can tell mark. I'm fine great. Someone wrote us on twitter. Economic high need advice. Visually-impaired thinking of getting a mac book pretty good time of the year to get a mac book now isn't it with all these them one proper processes out there if only had prime day if only the at prime day well this person is equals in. Where she she is she he. They i'm. I'm very confused by pronouns these days but this one doesn't have pronouns. Here in west yorkshire. It's a shame prime day is finished. Not still inside. Yes i guess. The entry level even macbook air. These days are super barbara. Mike boo here and one gophers the base model. Honestly you will not need any more. This won't people out there trying to buy the sixteen gig to to come by all the only thing i would say. Go for the base model with five twelve gig. Ssd that'd be my take on it and actually you can. Some deal and amazon weirdly. Good deal on them through the year. For some reason you can get some money off. It's just i phoned the two hundred and fifty six gig version just left me wanting especially we start adding applications start doing stuff. You don't always a new video stuff and we're doing a live audio so yeah ok does pile up. But even so get applications on their the arm beefy as a technical term beefy. These applications So you probably want to have a space on their show and mariah. Yes i think so. That's the point right exactly right. These are sealed. That's it so you buy as much as you can at the beginning and the m one ship just changed the whole thing right because the performance amongst all of them are much stella anyway so it doesn't matter you're not gonna lose out on anything so it depends really what your use cases because i. I love the mac mini. So if you do need a laptop then the air is a great way to go. But if it's just for desk is going to sit on your desktop. Then go for a mac mini and one mac m one and you get the the hardest size that you you need depending on what your use cases and yeah. They're going to be great. And as we know voiceover totally accessible learning curve depending on where your star in from But yeah a great choice. Yeah i mean. Don't buy until this point anymore. No point at all What were you mark because no. You've still be big night. Pro obviously is a beast of a machine is great. I love it still. It's still i mean. I don't think this thing is ever gonna slow down a bit. I mean you know. In retrospect i don't think i would have bought it. If the ones around i probably would have gotten a beef your one. Have you gone in. Wanted the minute i do. I have the mac mini the m one. Mac mini a high defined it compares. I'm guessing united in the same things but it's diff- ready. No i've tried doing render comparisons in the macro still kind of blows it away I mean i've got the after burner card and all the stuff in the mac pro that just inherently is just unless the honesty bit peeved. If didn't right. I mean you'd be like if my loved. I'm ready peeved that i bought that macbook pro that sixteen inch serve. Anyone wanted disease. Does he does that. They can't even sell it if i wanted to do. I have to wait. Oh going to question for you ed. The masking for frontier. Okay assistive touch of the iphone. So that's a little dot that kind of hovers anywhere and really helps you. I've turn this thing off every single day by going to settings by going to accessibility rayson General there sensibility. Yeah And i turn it off at keeps coming back you on your running a bt there are you fifteen beata by might be a problem but but if teammates iowa's fourteen point seven beta okay. He she's been going away. Yeah there there is no other thing. There's no like hockey or like something that could be accidentally hitting then turns back on now. If you're telling our cut well. I mean you got the triple click of the side. Buttons bring up the accessibility shortcut let me say build all now. Yeah so i should be default. Shouldn't item should be. I mean it is not the is but it should be. They should be yeah. No you're doing everything right. Mark i put it into the pizza. Okay well then thank you for nothing. Yeah okay. Any questions from the world of mark have a good show thanks. Let's talk about windows. Eleven because is coming. Soon we We are only a as happened. So i think we'll actually be on a After the announcement has actually taken place so yes listening to this right now. You know more than us which in venus us nothing unusual. But what are we thinking we were going to do. We're actually going to have special feature. On the show was gonna do a big feature widow plunder and frankly i don't think he could be bothered that's the prob. He couldn't be that he was too busy looking at this ridiculous hawaiian shot. It couldn't even be bothered to do the feature. No i just didn't see the point of it. You ida feature by you know what to expect windows eleven and what was coming up what we knew people here. They already know what you're really worried about is that you're going to have accurate information. And they're going to find out all this stuff and you're like oh. I mention that because i didn't know about it at the time. Yes exactly what i do. Want to make a fool of myself because that never happens. No alaska while. I'm glad you didn't do that But instead we're going to talk about something else that's coming up because uk went to slow them. We'll talk about it next week are ever going to call it. I assume it will be a windows. Eleven us we'll get into that next week by also and a taco samsung and google working together again. That little kids playing you having a good time and now that all shading them toys which is lovely and next week. We're going to hear about a brand new smartwatch from samsung. this is going to be happening at. I guess a virtual mobile world congress event in barcelona and has been new smart for a watch launched by samsung. But this time is going to be running weirdo. S some some had their own operating system called tyson and if dish that and working with google tashaun create this new. Small portion of this is interesting because this is the first time. We're seeing that happen. And this is two companies coming together at. Why thought by this point we'd have been talking about the google pixel watch. But that doesn't seem to have materialized And i was told by some very good sources that that would be happening this year. Now of course he is not yet so mobile. Come but our thoughts here. Samsung bringing up their own. Smart wash widow waco. Oh s walking with android google to us. We we excited. I mean we don't go wrong. I mean this is. This is a great recipe. Here you got the great hardware manufacturers in the world you know with one of the best software manufacturers in the world to can't go wrong here yeah and this is an interesting partnership because they've been doing this. I mean if the first big announcement we saw samsung and google walking together on told back the android as the screener which i thought was quite interesting. Because for two companies like that you wouldn't think that's how they would start working together but it does seem an item number but were An event would be twenty nineteen. Actually it was the texture proven. We were at in london and remember someone from apple. I was talking to actually time. Having a conversation with someone with google. And i ended up in the middle of this conversation done and i said to them. Isn't this funny you to actually speaking to one another. This is weird. This must and the person said this happens all the time you people think we don't talk but we actually do. We share ideas And that point. I had about fifty questions ready to say. Well can you fix this and can you fix that and why we work together. And why are you doing this to more multi finger gesture and all this but the point is that they do altogether so and the accessibility side. The seems to be some unity On the face of of course. These are competent. These companies are competing against each other right. So i just find it quite interesting. They're working together. But it's really good. See samsung google doing this show from an accessibility. Point of view Tizen from some did have accessibility in it. It did it did have a screen Magnification zoom options in the. Watch the same with google and wade awareness on the selected watches. It was available on a you excited about a coming together because it sounds like accessibility been said. I think accessibility will be at the heart of this which means a competitor. Cds competitor now for the apple. Watch exactly the point. Yeah because so far when it comes to accessibility. The apple watch is the only option. Now i know there's going to be people at their point in various android. Wear what you're saying. No this is accessible but stephen. You've had some experience of using an android wear supposedly accessible watch. And yes while technically. It's accessible the us usability. Exactly the issue. It becomes clunky to use thought party apps not working properly all the challenges there yet. But that's the problem for me. You know that's why. I always goodbye because everything will napa okay. I'll be fair. No everything and apple watches pathway. Tither no no not no but it's it's closer to it far more responsive i just i i really do like android watches the mob. Voi- take watch pro three. I think is this a lovely watch. Great battery life brilliant. I wish it was just a bit more accessible because the problem is not the accessibility is actually once. You get a running the problem. Is you need cited assistance to get it working. Well there's the straight away that's a fail- exactly sorry if you need. Yeah no. that's no good. Can we to it yet. Samsung google working together as mark said that the hardware at samsung produces beautiful so this is exciting and android wear itself as a core. I think google They needed help with it. Because it for whatever reason it never really they never really got to grips with it. So yes this is going to be a good thing. And it's something that we should watch because the lightly case is if they get android wear software working To a certain level you know the amount of Watches us going to be available on if the accessibility is up to par. It's going to be a good sign for us. So yeah i'm quite excited dami too. I'm really looking forward to that will do me a nice new smartwatch to play with Of course the interesting. Yeah exactly the thing is though. I walked for older samsung smart watches. We'll get the update that takes because that's a different operating system right away the old stuff rams into crush isn't it right sicker loss to come on double tap canada. Double tap canada. We'll be back after this. This is double tap kennedy now back to the show and love that i love you say genomic sciences. I'm excited because this week this week on the mit. I think we best double tap tv. We've ever done a pretty good episode. It was really pretty shitty. Runabout postal klopp. I'm gonna get sound defects in for this one. Don't do real talk. Yeah go berlin. We spoke to. Don't make it so. We spoke to the wonderful accessibility at samsung Talking some actually you can check out the show here on. Am tv peace through the week and you can also get it on the tv up and also on the youtube channel as well just social acceptable media inc. Whatever you get your youtube next week. Well this week. I should say we're talking about screen reading what's next week next week year next week. Choose me we're going to be Heating screen reading and twenty twenty one special guest matt. A tear is going to be joining us from jaws the Screen routing company. Very excited to get him on because he's got some interesting stuff to talk about from the company's perspective and one of the things that he's going to be talking about is that big challenge that we're all facing all these companies facing at the moment around cost you know screen readers and particular on available on pretty much every platform for free. So how does a company come along and charge some money for their screen reader. Sean here be entreaty conversation. I'm guessing absolutely and some of the points. I heard matt raise on other other times. Is that there's some features in jewels that i want to try again. I'm going to go back to jewels and give it a go because signs interesting. Did i tell you guys when i got this week. Gordon please marks awake of time. How long do we have two minutes to starling starling garage. Course darlene. Set this up center when it comes to this really giant box you get the satellite dish with legs it literally just pop it on outside somewhere with a clear view of the sky you turn it on plug in it moves it. Does its thing it connects to the internet. And i got. This is my first speed test. Okay and starlink and It blew my mind incident over the satellite internet over satellite two hundred and thirty six meg down and fifty one point six. Make up forty seven of of ping so. How does that compare to your connection. Just now bobby. maybe not. Maybe not the speeds but the the millisecond latency does i again. I have a stupid connection at home. I have Ping like one millisecond car. Okay so it's me and my download right now is five thirty while we're connected uploads probably about seven hundred but but think about some rural communities that. Don't even get twenty five meg down and one meg up to suddenly be able to hit speeds of two hundred and fifty. Yeah that's awesome insane. Yeah and those lucky to get to make you know and and it was so my brain working overtime right. I'm like oh well. Can i broadcast over this. So i tested some of my quit yet problem so i can i can be on a cruise in the middle of the ocean and be broadcasting. Live somewhere i could be in the middle of field somewhere. He could be in the endless point in the world and the planet and you can broadcast live stevens new shed tears. I if you're going to be the most editing crucial passenger known to man not get tv signal or mobile signal because all be taken up by this. He and his day he'll get the balcony and he'll put this big satellite dish off the ipad. Pro the big ipad really. It's not it was or beach umbrella. Easily enough hold it with with with one hand and just kind of walk around with fitness uk. What time's up for essay. Last coffees just kicked him. Hey listen listen keep in touch and let us know how you go ahead eagles starling. That's sounds amazing to me You kind of close contact us and all the usual ways you can call and leave a voicemail remember let us know so can your voice on here and we'll play out right here on double canada candidate. Four four nine seven one one nine nine nine is the number eight four four seven one one nine nine email feedback at. Am i dot ca ache out. Of course you can tweet us at double tap canada where you find me at tiktok steve. He is at the blood note and he is at marka flannel guys. Thanks gamble catch time. Thanks for listening. And heath your feedback coming. Call one eight four four nine seven one one nine nine nine voicemail email feedback at am dot ca. We're also on twitter at double tap candidates and on facebook can't wait till next week. Ask your smart speaker to play double tap canada or listen on the podcast app of your choice. Thanks for listening..
Good Life Project
"genomic science" Discussed on Good Life Project
"Diabetes cancer heart disease. They go quiet. This is what's called epa genetics. Epigenetics is understanding this gene. You have but whether you turn them on or off. So what they found is that day of meditation turns them off while that was a shock to people in genomic science. They didn't think that a day of any kind mental activity when affect your gene activity in the least so along the way there have been many discoveries that are i opening for science as we know it today. I think in the future. It'll be taken for granted. Yeah is there an understanding of why they can that example that you just gave you know you sit for six hours or whatever the meditation for six hours it starts affecting on epa genetic level. Why is there an explanation or is that still an open question. Maybe i think the specific mechanisms quite unknown. Yeah but we know there's a general correlation between mood states and health and this may be one of the linkages that explains his. Yeah and like sitting six hours but spread out over twenty minutes a day for x. number of days doesn't have the effect doesn't seem to so interesting so it's so it's not just dose-dependent in terms of like this much every day for a long time. It seems like intense periods makes with almost like interval training exactly so the data so far seems to suggest that the benefits of meditation are enhanced by retreats full days. A week a month of continual meditation which is like going to you know professional baseball players. Go to camp in florida for this to up their game. So why not the mental game. It's the same. Principle has to do with mastering expertise in any domain. You know the the ten thousand hour rules kind of being that surround smith. It's generally that the more hours you put in the better. You get but the key differences this in any domain meditation. Chess math doesn't matter golf. Most amateurs improved their game about fifty hours. And then plateau the pros. All the pros have coaches and they keep working on whatever it is. They need to improve all their lives. And that's why they're at the top of the game. So the yogis for example that davidson studied at wisconsin. All teachers have teachers continuously all their lives. Who were somewhere more advanced. What they're doing just like Professional singers opera singers. Have voice coaches same thing so interesting to hear you say that makes perfect sense. I had the chance to sit down with a k. Anders eriksson who was the source of the ten thousand salutes. We now know is. He's a little miffed at the house. That's not quite legit said. But but he's he said the same thing like the best of the best in any no main. He was really speaking to the role of the teacher in the process. Yeah somebody who can look and serbia part of it and say okay. We need to keep continually shifting. How you're going about this so that it's not just showing up and doing it by road but actually saying okay. How was that and is relating iterating on this but in the context of meditation. I've almost heard that yes. I've heard that a that. A teacher is important. And at the same time i've always heard some variation of the instruction of most important thing to do is just show up and sit every day and don't judge the quality of any one given time on the mat. Yes but you're seeing both are true. Okay i think it's important to have a non judgmental attitude toward given meditation session. All kinds of things can happen like when you go to the gym. And you're going to say you're doing nautilus machines judy's repetition every time you do the repetition your strengthening the the muscle just a little bit. You may not enjoy it as much as you did. Yesterday doesn't matter same with education every time you focus on your breath and your breath wanders you notice wandered you. Bring it back. You strengthening a little bit the circuitry for concentration. It doesn't matter if you enjoy it or not just that you do it. So that's true on the other hand a teacher meditation might say. Well you've really got your concentration down that see if you can gain more insight. Watch your thoughts come and go. Don't treat them as distractions. Well that's a different instruction and it needs to come at the right time or helpful if it comes at the right time and it turns out there instructions like that all the way up the ladder and i don't even know what the top of the list is and it makes complete sense the when i think about the quality of my practice so i sit daily just might very fundamental breath oriented. Mindfulness practice been doing it. I is two thousand ten. And i'm not in love with my practice like like i don't sit and see and feel amazing. No it's not. The is not my experience. Nobody ever promised to me. Should promise you got took me a while. Understand that. that's okay. Yes yes exactly. And in fact i was just talking to someone who said you know i try to meditate but i think my mind just goes crazy. I can't be imitator. And i said you know. Actually that's the first major insight. Congratulations because you're looking at your mind. We don't realize how busy are mind. Is all the time until we stop and look at it in meditation and then. I don't know if this happened with. Jonathan certainly happen to me. You realize your mind is wandering all the time. That's a state and meditation is the attempt to.
Good Life Project
"genomic science" Discussed on Good Life Project
"No no in fact other scientists are just amazed. There's some other amazing findings that occurred. You don't have to be olympic level long term meditators. People who been practicing every morning for years sometimes go to a retreat for many people like that if they do one day of meditation like six hours or so. There's what's called a down regulation of the genes for inflammation that means the genes the create inflammation throughout the body which are at 'cause in a wide range of disorders. You know arthritis diabetes cancer heart disease. They go quiet. This is what's called epa genetics. Epigenetics is understanding this gene. You have but whether you turn them on or off. So what they found is that day of meditation turns them off while that was a shock to people in genomic science. They didn't think that a day of any kind mental activity when affect your gene activity in the least so along the way there have been many discoveries that are i opening for science as we know it today. I think in the future. It'll be taken for granted. Yeah is there an understanding of why they can that example that you just gave you know you sit for six hours or whatever the meditation for six hours it starts affecting on epa genetic level. Why is there an explanation or is that still an open question. Maybe i think the specific mechanisms quite unknown. Yeah but we know there's a general correlation between mood states and health and this may be one of the linkages that explains his. Yeah and like sitting six hours but spread out over twenty minutes a day for x. number of days doesn't have the effect doesn't seem to so interesting so it's so it's not just dose-dependent in terms of like this much every day for a long time. It seems like intense periods makes with almost like interval training exactly so the data so far seems to suggest that the benefits of meditation are enhanced by retreats full days. A week a month of continual meditation which is like going to you know professional baseball players. Go to camp in florida for this to their game. So why not the mental game. It's the same. Principle has to do with mastering expertise in any domain. You know the the ten thousand hour rules kind of being that surround smith. It's generally that the more hours you put in the better. You get but the key differences this in any domain meditation. Chess math doesn't matter golf. Most amateurs improved their game about fifty hours. And then plateau the pros. All the pros have coaches and they keep working on whatever it is. They need to improve all their lives. And that's why they're at the top of the game. So the yogis for example that davidson studied at wisconsin. All teachers have teachers continuously all their lives. Who were somewhere more advanced. What they're doing just like You know professional singers opera singers. Have voice coaches same thing so interesting to hear you say that makes perfect sense. I had the chance to sit down with a k. Anders eriksson who was the source of the ten thousand dollars salutes. We now know is. He's a little miffed at the house. That's not quite legit said. But but he's he said the same thing like the best of the best in any no main..
C-SPAN Radio
"genomic science" Discussed on C-SPAN Radio
"So you authored co authored a piece in The New York Times, which gave us the idea for talking to you further about this about the cautionary notes. So what are the kinds of challenges that the American public should be aware of about the development, safe development and distribution? Of of a Corona virus vaccine. Sure, well, one of the first of them is the fact that any vaccine that's tested is tested in Large group of people, but not nearly as large a group of people as it will ultimately be used in so in this country, we try to monitor as best we can. Vaccines as there used so that we can keep tabs on any unwanted side effects that only show up say when a million or two million people have received the vaccine. So that's one thing that I think we need to keep in mind. I think the other one is we have. I think it's well over 100, different vaccines and development right now. All using different approaches to vaccine development, and this means that there may be a top vaccine candidate. That uses a technology that we haven't used or haven't used extensively before, And we need be calling, as we did in the days of polio on manufacturers who haven't actually manufactured a product like this before. So we don't In such a case, we again won't know if there happened manufacturing problems until the vaccines are widely used. I don't mean to sound exceptionally cynical or skeptical here we have spent. In fact, using polio is our starting point decades, refining. And adding on to the safety and regulatory procedures in place for ensuring that drugs that get to market are not just safe but also effective at the same time, and that effectiveness does not compromise safety and vice versa. And what we've heard in the last couple of months as some of our leaders telling us that a number of regulatory protocols are now being set aside and that they're being Set aside in the interest of bringing effective drugs to market quickly. I hope this doesn't have negative consequences, and one can never say I just know that we spent decades putting these regulatory processes in place for a reason, and I hope that one lead Put them back in place when and if we can put this pandemic behind us, And to that the ways in which we're trying to make vaccine development more efficient now, don't comment. Any state costs. We will already be dealing with steep with it costs because we will face distribution problems we will face Problems of equity. Even if we have enough vaccine for everybody, there will be those who have the privilege to say. I'm not comfortable getting it until you know five million people have been vaccinated. Then there will be those who say I have to get vaccine because I have to go to work and I have to make sure that I am safe and that I can provide for my family, So I guarantee that we will see problems of equity Historians are supposed to guarantee anything about the future. But I This is one thing I feel concerned about. What didn't exist in the 19 fifties is genomic science. So how does the cracking of the gene helped with the development of vaccines today? Well in a couple of ways, and I'm not a scientist, so I'll just say a few brief things, but from my understanding of it is once you can see the genetics of a virus like this. Strangers can design a vaccine very quickly. That means they can essentially like an architect come up with with the blueprint for it. That doesn't necessarily mean that it will be quick to build it or to test it. But you could design it very quickly and you can design it in a very refined specific way. It also means that you could use you can produce vaccines that look potentially very different from the polio vaccines that we've been talking about. They don't continue the whole virus either killed or we conform. They just contain genetic material from the virus, or that resembles the virus is genetic material. And that's familiar enough that they need just the human body recognizes it and round suddenly response. So yeah, I like those two differences. Last month, There was a headline in the Washington Post that read that Corona virus may never go away even with the vaccine. So are we as a global society looking at eradication of coca 19 or containment. I think that we probably need to focus on both. But one thing that I am struck by again as a historian, not a scientist is that I am now living through a pandemic that has caused the kind of social disorder that I have read about in history books that have never lived through in my own lifetime. Polio is is a close example. But that happened before I was born. But if you look at the history of infectious disease you see diseases such as No. Smallpox is one plague is another yellow fever. Cholera. Smallpox is the only one on that list that I mentioned that has been eradicated. Polio is close to eradication. Plague is still with us and people think Oh, played. We haven't had that since. You know the black death of the Middle Ages, but it's it's still a presence. We just contain it, and we manage it. And that is a possibility for Corona virus. We may never develop a vaccine against it on DIT may be with us for centuries that may be with us for millennia. And if it is, it will mean that we have found ways of not just containing two it containing it, but adapting to it as well. So in our few minutes left, I would tell people that you wrote a book about vaccines, called Vaccine Nation and published in 2015, still widely available of people are interested in it..
Science Friction
Do genetic ancestry tests know if youre Palestinian? A cautionary tale of race and science
"Welcome welcome to size friction on the tension ritual in. Today's episode is Genomic Science to go to striking story for you of the shocks. You can engage when you take a genetic ancestry tests and the problems are not in your Diana. They are in the science. Oh man so so I want you to make mercury eight to buy. Oh my gosh. So she's an American Palestinian cartoonist illustrator. Leaving in Brooklyn New York and when Shae Shea started to draw well I kind of helped his stop making sense of the world. When I was younger all I wanted to do withdraw from Warwick fantasy characters? who were you know exploring some fantasy world adventuring trying to figure out the meaning of war? Yeah you Matz I. She was an intense keyed. He'd sigh relate to that. I'm not even joking. That was my first comic when I was like thirteen or fourteen trying to figure out the meaning of war yes the law plot. What was really hard? Core rate was trying to figure out the world her family stories. We're helping figure out a self my family. So my my Palestinian side of the family were originally from Ramallah they came to the US in the sixties after the nineteen sixty seven war. And and. That's where my father. My mother my mother is mostly of British and Scottish ancestry and they met in DC and the register and Marguerite was born. She grew up in San Francisco but she understood whole lot about the deep heritage in history. If if family I lived with a lot of my extended family on my father's side and and the constantly I mean I think it's a very Palestinian thing to talk about loss. I'm sorry to say Palestine and talk about what was lost in talk about how it was and things like that so I heard very much about out where we were from and how it was there and everything and there is actually a book. That is a congenial logical history of Ramallah so my family needs to say his in this book. This is actually a book that was done maybe thirty years ago. There's actually a recent effort to update the books so this is kind of a big thing and it's very much a Palestinian thing to try to keep memory alive. It's a need to assure after that. Hey you know we exist who've had the we had this entire history. We're going to write it somewhere. We're going to you know. Put it somewhere. I wish I could've seen Palestine back in the day honestly because it just sounds really chill a nice. I'd like to go okay. Okay so mercury thought. She had a pretty clear idea about her ancestry but then she sped into a test tube. Well first half-brother on her father's side spat into a test tube. He decided on a whim to take a day and I taste and he got the results back in he was just blake. Yeah you might want to take a look at these results. He's her kind of weird. Well we'd in an intriguing conaway. Our understanding ending was that from my Dad's side. We were fully half Palestinian half Arab but these results they suggested something different so so we were just like what so marguerite decided to do an ancestry test to this was back in two thousand sixteen. They went through twenty three and me did the all spit in a tube and she said it off to the company twenty-three May and literally Chino. Even more surprises would be in store for her so the saliva gets to our partner lab. The DNA is extracted from that. and My name Ms Joanna Mountain and I'm senior. Director of research at twenty three and me and previously at Stanford with Joanna also did her PhD and specialized in human evolutionary evolutionary genetics. So when customers sign on with the genetic testing and Analysis Company twenty-three May which is headquartered in Silicon Valley. He's what what happens to this speech sample around a half. A million positions in the DNA are analyzed and we get the genetic variants at those half million positions genetic knitting variant. Now that just means some kind of unique variation in your genomes deny say quance so then twenty three and me use an automated computerized Haraz prices to p different stretches or windows of your day and I and then I compare those two James off a reference group made up of individuals individuals from different populations globally. Now what ethnicities are present or missing from that reference group. That's K. as you'll he'll IDA and and we look at each one of these little windows and we say to which people is this individual most genetically similar and we continue as we stroll along the genome looking and saying well at this point this genome looks very similar to people from say Iberia and then we get a little further down in. Wow it looks similar to people from commoner and even in further down. It looks similar to people from Ireland. So there's a method we have that classifies each little patch of the genome by saying. Is this more similar to people from Ireland Orland or from France and then the algorithm says okay the probability that's from Ireland and appropriately. France in whichever is highest. Is the winner there so then we patch it all together come up with percentages for each individual so it's a multi step process and that's what we present to the customer okay so back back to margarite radium waiting for the results from twenty three and May to land in her inbox and sure enough. I got I got the results back and Some of them made sense. You know I knew enough about my mother's side of the family told me that okay. HALF OF ME is British and Scottish Scottish. Okay cool makes sense what came next made very little sense to her. Other half is going on percent Italian Elian it said thirty five percent Italian and then the rest was Arab Specifically Oh what did it say. Think specifically had said western Western Asian or something they actually tried to give me a breakdown of what regions of Italy it came from but they couldn't actually detect wherein Italy. It came from at all Wade. It'll Italian come from and actually I think is sweet coincidence. Is it true that your husband is Italian. My husband is Italian and I did actually when I got the test I did ask him like do I look talion. He was just like no suddenly just like that. Migrate was possibly thirty percent Italian and only fifteen percent western Asian and north African and canete slightly saving detail that she is Palestinian heritage. We'll wait until you hear what happened. Win Twenty Twenty three and may updated her results two years later. It's fairly incredible. I though Hel genetically different we really well at the genome scale there. Her over three billion nucleotides that make up our genome. So My name is Sarah Tishkov and I may professor of genetics awesome biology at the University of Pennsylvania and she's hugely influential Sarah and colleagues published the first pipe to support the out of Africa hypothesis of human migration using analysis of the DNA inside cells Nuclei and has conducted the largest studies of genetic variation in in African populations. We differ at about. I would say less than point. One percent of the genome. So that's a relatively small mall amount of difference to give you an idea of we. Compared the human genome to a chimp genome. It differs at about one point. Five percent of the genome less than point point one percent and yet what is contained within that variation that difference the majority of variation is not functional and in fact that variation is very useful for making inferences about evolutionary history about population history demographic McGrath history tracing migration events and so on the part of the genome it actually is influencing variable traits is important for understanding how how we adapted to different environments during human evolution and also understanding why some people are more at risk for certain diseases than others