35 Burst results for "Gehrig"

Major League Baseball to hold first Lou Gehrig Day on June 2

AP News Radio

00:46 sec | 2 months ago

Major League Baseball to hold first Lou Gehrig Day on June 2

"Garak joins Jackie Robinson and Roberto Clemente as players who are honored throughout the league I consider myself the luckiest man on the face of the earth June second marks the ninety sixth anniversary of when Gehrig started at first base for the New York Yankees in place of Wally pipp starting his record streak of consecutive games played June second was also the day in nineteen forty one Gary died at the age of thirty seven Amiot trophic lateral sclerosis or ALS I might have been given a bad grade but I've got an awful lot on June second each home team will have for a LS logo's in ballparks to mark Eric's number for money will be raised to fight ALS also called Lou Gehrig's disease I'm at Donahue

Garak Wally Pipp Roberto Clemente Jackie Robinson Gehrig Lateral Sclerosis New York Yankees ALS Gary Mark Eric Lou Gehrig Donahue
Pat Quinn, co-founder of viral Ice Bucket Challenge, dies from ALS at age 37

Charlie Parker

00:30 sec | 6 months ago

Pat Quinn, co-founder of viral Ice Bucket Challenge, dies from ALS at age 37

"The A L S Ice Bucket Challenge. Has died. Pat Quinn died at the age of 37 yesterday after seven years with the disease. Quinn and the late Pete Frates started the challenge after being diagnosed with a L S, which is known as Lou Gehrig's disease. The ice bucket challenge raised over $250 million Since it took social media by storm in 2014. Those of you do not know

Pete Frates Pat Quinn Quinn Lou Gehrig
Pat Quinn, Ice Bucket Challenge co-founder, has died at age 37

News and Information with Dave Williams and Amy Chodroff

00:47 sec | 6 months ago

Pat Quinn, Ice Bucket Challenge co-founder, has died at age 37

"J. Powers, Fox News Another co founder of the Ice Bucket Challenge, has died. Pat Quinn, motivational speaker and co founder of the Ice Bucket Video Challenge for a less died Sunday morning at age 37. He battled Amy a traffic lateral sclerosis, often called Lou Gehrig's disease since diagnosis in 2013 the video challenge taking social media by storm in summer, 2014. Quinn talking to Fox News radio in 2015 disease that has no hope at the moment, but The ice bucket challenge is revamped that outlook the challenge so far raising more than $250 million worldwide. Currently, there is no cure for a less a fatal progressive nervous system disease, which impacts nerve cells in the brain and spinal cord, causing loss of muscle control.

J. Powers Ice Bucket Challenge Traffic Lateral Sclerosis Fox News Lou Gehrig's Disease Pat Quinn AMY Quinn
Pat Quinn, Ice Bucket Challenge co-founder, has died at age 37

John Batchelor

00:46 sec | 6 months ago

Pat Quinn, Ice Bucket Challenge co-founder, has died at age 37

"And another co founder of the Ice Bucket Challenge has died. Pat Quinn, motivational speaker and co founder of the Ice Bucket Video Challenge for a less died Sunday morning at age 37 He better of India Tropic lateral sclerosis, often called Lou Gehrig's disease since diagnosis in 2013 the video challenge taking social media by storm in summer, 2014. Quinn talking to Fox News radio in 20. 15 disease that has no hope at the moment. But the Ice bucket challenge revamped that outlook, the challenge so far raising more than $250 million worldwide. Currently, there is no cure for a less a fatal progressive nervous system disease, which impacts nerve cells in the brain and spinal cord, causing loss of muscle control boxes.

Ice Bucket Challenge Lateral Sclerosis Pat Quinn Lou Gehrig Quinn Fox News India
Pat Quinn, Ice Bucket Challenge co-founder, has died at age 37

Always in Fashion with Mark Weber

00:28 sec | 6 months ago

Pat Quinn, Ice Bucket Challenge co-founder, has died at age 37

"Co founder of the ice bucket Challenge for a less died this morning at age 37 he better Amy O Tropic lateral sclerosis, often called Lou Gehrig's disease since diagnosis in 2013, the ice bucket video challenge taking social media by storm in summer. 2014. Quinn, talking with Fox News radio in 2015 is great for the A L s community. We really needed a new sense of fight new sense of hope. So far, the challenge raising more than $250 million Worldwide.

Tropic Lateral Sclerosis Lou Gehrig AMY Diagnosis Quinn Fox News
Co-founder of viral ALS Ice Bucket Challenge dies at 37

The Armor Men's Health Hour

00:28 sec | 6 months ago

Co-founder of viral ALS Ice Bucket Challenge dies at 37

"The Ice Bucket Challenge for a lesson. This morning at age 37. He battled Amy Oh traffic lateral sclerosis, often called Lou Gehrig's disease since diagnosis in 2013, the ice bucket video challenge taking social media by storm in summer. 2014. Quinn, talking with Fox News radio in 2015 is great for the A list community we really needed. A new sense of fight new sense of hope. So far, the challenge raising more than $250 million Worldwide. America's listening to

Lateral Sclerosis Lou Gehrig AMY Diagnosis Quinn Fox News America
"gehrig" Discussed on The HeFluence Podcast

The HeFluence Podcast

04:56 min | 10 months ago

"gehrig" Discussed on The HeFluence Podcast

"This people like to buy stuff and if you have a service in a product that you believe in, which is huge for me if I don't believe in selling it but if I believe that's why I'm doing what I'm doing. That's why I'm doing what I'm doing because I I. Didn't understand the industry I didn't believe in I was looking for something different. That was I'm a forward thinker. So yeah. So if I don't believe it, I'm bringing a supplement to market right now I just start a supplement company I drink these things I drink myself every day. Right? There's a whole different topic but I, the reason why I'm willing to take it on and sell it is that I believe in it one hundred percent I would I would give it to my wife and she takes it Right and so this that's the big thing is that if I'm if I have a product or service if the biggest thing is that two things time management and I don't think you can really manage time but you can plan for it. So if you if you're not selling enough or you're not your business isn't where you want it to be your proud your time is probably off and I can't go into it. Now Mike all the tips around that but that's I talked to a lot of people I've coached a lot of people most people they have an issue with their calendar. That's the first thing and they don't prospect enough and prospecting can be done a multi ways and you can't outsource it. So if you don't like prospecting, you'd better have the money to outsource it. So that's the two things like if you're most the number, one thing though majorly is people's time they just they let people run their calendar and I don't see. I HAVE CO CO coaching clients, they WanNa talk at eight am sorry. That's what I'm getting ready for the gym I gotTa be at the gym at eight thirty. So no I don't talk. Then that's just it is what it is and I I decided my time manager. If you don't if you're not if you're not doing that, then you don't think highly enough about your product because people are paying you know pay me a lot of money. Some people might think well they bend. Over backwards no they're paying a lot of money because on the authority they want you time they want you they will pick a time and it works. Why does it work because I tell them? This is all it's available. You pick one. So I used I can only say that because I, used to let people run my time I used to work a hundred hours a week I miss my son's first birthday. I walked away from an eight figure payout equity ownership in a company. Because I knew that for the next five years, they were going to own me and I said, it's not worth money to lose my family when I sandy and I was losing both gone up to two hundred, sixty pounds I was never sleeping. I got a half day for my five year anniversary, right propose to my wife again a half day I was working seven days a week. There wasn't a burning candles at the whole both ends of the second little just dropped the candle. In the fire because I was also on call in the middle of the night. So you know my thing is, is like you if you don't have a vision and I'm actually launching a group thing right now and the and the three things I'm covering it's it's very covert kingdom. So this while end with because this is my tip, the three things that I teach people as you have to learn how to fortify your face, your family, and your follow through and inside faith is. Vision Action Right. So those things are huge..

Mike
"gehrig" Discussed on The HeFluence Podcast

The HeFluence Podcast

03:09 min | 10 months ago

"gehrig" Discussed on The HeFluence Podcast

"So anyway, the health thing like working out like today we did legs and we just we go in and we annihilate our legs and that's what we love to do and that with your wife yet we work out together. As a week and so we do We should we do various workouts but it's very much. It's very like bodybuilder esque workouts Do we typically do like this is our cycle. We typically do leg three times a week and upper body twice a week or we'll do legs twice upper body twice, and then a full body and I actually don't go heavy right now definitely upper body so I'm I like do real slow and controlled I tore my pet last year doing a cross cross pit workout. So tore my pack muscle and so that put me down for a while. So like you know even though I did that, my chest has gotten bigger and when I go in I literally am benching twenty five pound dumbbells that's it and my child do the same thing. So I can I put on seventeen and a half pounds of muscle in nineteen, twenty, nine, thousand, nine yet well, I have a size I'm two, hundred and thirty pounds and I have a size thirty four inch waist right now. Okay. Well, we're like the same size to thirty I'm thirty two right now ways awesome. Yeah. So the you know the when you're. Working out I used to think, hey, go heavy, go hard or go home but actually didn't build muscle during that time. Now you don't sell wasn't until I met my wife that she taught me how to work out and So it's been a lot of fun. So health is number one. So now moving onto the relationship thing like man. So why don't we just segue into saying expen- actual one on one time with your people you hold dear to your heart. So right like my wife is super important to me. So I built my schedule since I'm a business owner, I built I schedule around making her first making. An. So let's go one step back. I said, my faith is I. I. believe that you know one hundred percent that men their relationship with God is typically a.

business owner
"gehrig" Discussed on The HeFluence Podcast

The HeFluence Podcast

04:08 min | 10 months ago

"gehrig" Discussed on The HeFluence Podcast

"So I thought what the Heck I'll finish school i. well, then I things got really dark because one month they kicked me out in other like you had to pay for it yourself and I was like Jeez. That's why I was going the military like I always wanted to serve the country and great benefit they pay for your college, College Yeah. So now I'm stuck and. I did well, in college I'm like I book smarts come easy to me. I was very blessed with photographic memory. I don't have to study a lot and college was easy. I. Still dropped out but it was easy like that was like I'm not spending more money. So nineteen years old and a guy calls me and I was like in a thirty day. Times, how God works right He'd like prepared my field, my mental field because for thirty days I said what in the heck am I doing why am I in college? I wanted to go in the military and I was I was living in this house where we partied every night I, mean we had a cake at nineteen years old. We had a keg. Day. And you know I had drug dealers living at my house to drug. There's one got at a Juvie and like that was a constant battle I was not for the drug dealers living there. But because I had a friend who was a drug dealer side at need their stuff and I don't like how they were trying to fake being hard and so it would just was like an unsafe place and I just like I had shaggy hair down my shoulders you know I dislike I was real like didn't really care a lot about things In Man I just shaved my head and smoked a little bit smoke, my last bit of marijuana that I had I was like I'm done, I'm done doing this like this junk that I've been doing and and I moved out I moved out and I moved into my own apartment and then in that same time frame I worked at this country club where I was the head service like there was the guys I was servant they were billionaires Wayne. HEISINGER MIAMI DOLPHINS BLOCKBUSTER LA nobody knows what blockbusters anymore today but but he he sold at. All those. Yeah. Yeah. So you know Wayne, Highs Inga, the guy, Mr Dubreuil the guy who invented the squirt bottle you'd have millionaire. I've just a bunch of people that were really really great clients in..

Wayne Mr Dubreuil marijuana Juvie LA
"gehrig" Discussed on The HeFluence Podcast

The HeFluence Podcast

05:13 min | 10 months ago

"gehrig" Discussed on The HeFluence Podcast

"I just was angry, but I wasn't like broken and so that was kind of like an interesting part of my story fast forward I'm in highschool moved in with my mom I hated being there she gets cancer and she's told she's GonNa. have six months to live at this point. I already wanted to go back with my dad and I had told him that I was getting ready to go back into high school and told him we're out in San, Francisco, Mongols, house, and alkyl man's house, and I said I wanNA. Live with you my mom call while I was there and she said, I'm an got six months to live and so my dad said, do what do you want to do and I said, well, I'll go back. She dies while she's still alive today three separate rounds of of you're done and and then many more things I, say she's like a catch got knives talk about God's Grace oh? Yeah. Well Yeah, and it's you know she's had motorcycle accidents she's been to Rehab. She's a she's been an addict before. There's like so many like crazy things like so God's got some big plans for her still under percent. So that was kind of like. That phase and so I grew up in such a I grew up in a Catholic household but it wasn't really Catholic. My Dad's old school. He's from Oakland. He's real hard. You know they had like that was in the day where like your you're gang was your neighborhood. The next neighborhood they would come to fight and they would just you know my dad was like that was his Israel hard guy when it comes like that and so we went to Catholic church just really appease grandparents and say, yeah, we went because my Nanna was just so adamant about like I want you to be in heaven with me when I get there and so I never learned anything because of that I just didn't know who god was the only time. I ever talked to God I was twelve years old and a kid that I babysat who was nine was murdered by a guy who took my place the one day I couldn't babysitting He stabbed the kid forty, nine times. It was like the most gruesome thing to happen in our town ever and so I remember I sat there just like crushed and I was like God. If you're real, why would you take someone that's not even ten years old and then I? Went about my life and moved to North Carolina I went I was around the Baptist Church because in North Carolina there's one on every corner exactly the Bible Belt Right Bible Belt and the guy that my mom married who great guy taught me how to play basketball taught me many other things but he was really just like a bachelor forty years old never been married and he married my mom who's been married three times had a bunch of kids. Bad for the guy. I. Love It. So he he actually had a church that his family started like one hundred some years ago and todd north, Carolina this I mean dirt roads like real small little church, and so they were real hell hell fire and brimstone and like honestly I just never I never gave in to it. I was just like, okay like I never just didn't believe it. I didn't really believe it but I always went to church because that's where he may girls in. North, Carolina. So. What my that's what my best friend whose dad was the he was the head over all the Baptist Churches in Utah County, which is Boone North Carolina?.

North Carolina Baptist Church Boone North Carolina Baptist Churches todd north Francisco San Israel Utah County Oakland basketball
Mind Over Body Cure

The Oprah Winfrey Show: The Podcast

04:53 min | 11 months ago

Mind Over Body Cure

"Well, we've heard quite a few people on this show and others claim that they have thought themselves well, even in the face of death, but what about those people who do get sick and do get worse and die. Are they being made to feel guilty for not thinking themselves well well. My guest today are on opposite sides of this mind over body debate. Doctors don't know why my first guest is alive Lynyrd, borden says He. He changed his attitude. Imagine summarize warriors fighting the cancer in his body. A month later, the cancer was gone my next. Gus was told she had eighteen months to live if she did not have chemotherapy for her breast cancer Jane, Griffiths says she refused the treatment ten years later. She is still alive. My next guest wrote one of the most popular mind over body bestsellers. Dr Bernie seagulls love. Medicine and miracles explains his experiences with. With what he calls exceptional patients who hill themselves in the face of death. My next guest is a doctor who totally disagrees with Dr Segel's philosophy Dr Shirley new says sick. People are being made to feel guilty if they don't heal themselves, and there is no proof whatsoever that any of this works Dr Newlyn is author of doctors the biography of medicine. My next guest got so tired of people telling him that his severe backache. Backache was his own doing because of a bad attitude and stress. He wrote a column in Newsweek. Magazine to complain about it. Meet Rabbi Benjamin Black and my last guest says when she was diagnosed with Lou Gehrig's disease, people wanted her to try acupuncture and Yoga and love to get well and Spain says she live as long as she can, but she is also planning her death. Welcome all of our guests to the show. Start with you. I'll start with you. Because is where we got the idea to do the show from that column that you wrote in Newsweek magazine. What happened? I suffered from a herniated disk and I was just looking for some sympathy. And, then I suddenly realized that there was a psychological change in our society. and. Everybody kept saying to me. Why are you doing this to yourself? You must be the victim of self induced stress. And what really got me upset was that I recall the friend of mine who had died of cancer. who was able to deal with the reality of sickness? But couldn't cope with the fact that throughout the last days people made him feel as if he was the guilty one because he didn't obviously want to get well strongly enough because he wasn't trying hard enough, and he would cry to me. Does this mean I'm failure? What I'm saying is that there's an extreme position today I grant of course that there's a great deal to mind body relationship I grant as well that there is such a thing as love, medicine and miracles. What I think is wrong is I believe is a rabbi that we pray for miracles, but we don't expect miracles and when they don't happen, say that anybody who isn't well must be guilty himself. Don't blame the victim. Victim. Do you think Dr Newland this is making? People feel guilty as they die well. There's no question about that. That's really not my problem with Bernie's propositions. My problem with Bernie's propositions has to do with the aura science that he puts around them, in spite of the fact that what he's actually done is to take an enormous leap of faith, which of course is the secret of it all an enormous leap of faith from certain experiments, which show something that we all agree on that. There is a psychological factor that involves the immune system I don't think any sensitive physician physician with any experience could possibly disagree with the concept that patient state of mind is very important in their illness. But along comes Bernie, and says poof. The mind controls the immune system direct quote, the only quote I memorized from the book burning so that I could use it today. There's no evidence of that, and as long as people continue to believe with their minds, they can control their immune system there believing something that they simply can't do. It's like getting high LSD and trying to jump off a roof and fly, but you yourself just said that it's an enormous leap of faith and suppose it does suppose it does control the immune system, but there is no proof that it does. It's not a question of there being no proof that it does or does not. It's a question of our already being so close to understanding the various factors that do control the immune system that we know that the mind, the conscious mind is only one small factor. What actually happens is that whether we develop immunity to something whether we can control the disease process has to do with three systems in our body.

Dr Bernie Seagulls Dr Newlyn Backache Borden Lou Gehrig Griffiths Newsweek Magazine Dr Newland Dr Segel Newsweek Rabbi Benjamin Black LSD Dr Shirley Spain GUS Jane Yoga
"gehrig" Discussed on Medical Mysteries

Medical Mysteries

01:30 min | 1 year ago

"gehrig" Discussed on Medical Mysteries

"gehrig" Discussed on Medical Mysteries

Medical Mysteries

02:48 min | 1 year ago

"gehrig" Discussed on Medical Mysteries

"Twenty year old. Stephen was on Christmas break from the University of Cambridge. It was nineteen sixty two and he was enjoying the much-needed downtime. It had been an incredibly incredibly odd semester one full of highs and lows both in an academic and physical sense until that fall. He'd never been clumsy but for the past few months he'd often dropped his bugs or felt a pencil slipped out of his hand for seemingly. No reason Steven didn't know what was wrong. He was frustrated but decided to take his mind off the troubles he headed out to. Saint Albans Lake to skate with his mom but again his awkwardness strock as Stephen glided over the ice. His skate hit a divot and he went flying. His mom watched from across the lake. It looked like a hard fall but nothing too serious except Stevens struggled to get up every time. He got to regaining his footing. He fell again. She knew it had to be more than just slick ice after. All Her son had been skating dozens of times but now his limbs shirk as Stephen struggled to get back on his feet. Something was wrong. She decided to get Stephen Checked out. Later that week. They went to their family doctor. He set them up for an appointment with a specialist once. The holidays were over but he didn't have any answers either instead. Just after turning twenty one in January of nineteen sixty. Three Stephen underwent a barrage of tests while his physicians tried to figure out what was wrong. After fourteen days of coking and prodding. The doctors finally had a general idea of what was going on. They sat there patient down and told him the news. Stephen Hawking had a neurological condition and only a few years to live when our bodies fail. We trust doctors to diagnose the problem but medicine isn't always an exact science sometimes. It's a guessing game with life. Or death stakes. This is medical mysteries. A podcast original. I'm Mali and I'm Richard. Every Tuesday will look at the strangest real life medical cases in history and the experts who raced against the clock to solve them as we follow. These high intensity stories will explore medical research. That might solve the puzzle this week. In part two will analyze all the evidence and try to find an answer..

"gehrig" Discussed on Medical Mysteries

Medical Mysteries

08:06 min | 1 year ago

"gehrig" Discussed on Medical Mysteries

"In the Nineteen Twenties and thirties. Lou GEHRIG was the first Baseman for the New York Yankees and a member of what many fans called murderers row because of their ability to crush the ball. He and his teammates were known for their offensive prowess at the plate and for winning numerous world series titles. Gary was a fan favorite but during the team's spring training and Florida in one thousand nine hundred eighty nine. He could tell something was wrong. Power that he'd been so famous for old but disappeared. He was often tired but had no idea why he desperately wanted to play every game and maintain his legendary starting streak but he also didn't want to embarrass himself by getting easily winded or making a mistake on the field even with the disappointing spring training showing he was given a starting spot once the regular season began after all. Gehrig was a in his manager. Hope that he would turn it around in March. Old reliable number four took his place at first base. Gehrig hope that he was passed whatever he'd experienced in the spring instead he got worse all through the month. His dominance at the plate was gone for good and people were noticing the notoriously harsh New York City press question GEHRIG's abilities. They noted that his hand eye coordination was still on point but garrick was struggling with power. He was hitting the ball but it wasn't going anywhere. His teammates noticed how he was struggling to. He was making rare errors at first and was incredibly slow on routine defensive plays on April Thirtieth Nineteen thirty nine. Gehrig went over for four. The played against the Washington senators. A hitless game had been unthinkable the season before but it was becoming his new normal. He couldn't stand to let the fancy him fade away. He knew he had to make a life. Changing decision on May Second. Dariga arrived at the stadium in suited up for the game. He laced up his cleats. And BUTTONED HIS JERSEY. He left the locker room and headed up the steps to the dugout there. He approached the Yankees Manager. Joe McCarthy and said that he was benching himself his starting streak was over at two thousand one hundred and thirty games but benching himself wasn't enough his wife. Eleanor noticed that something was very wrong with her husband at home and grew worried. Gehrig told her that he could feel weakness in his arms and every so often he had a tremor as he worsened she called the world renowned. Mayo Clinic in Minnesota. She told them of her husband's ailment and a few of his symptoms. The physicians agreed to run a few tests. Gehrig was a huge star and they were happy to help him out on June thirteenth. The GEHRIG's flew to Minnesota. He and his wife were hopeful that they'd finally get a handle on. Whatever was going on at the Mayo Clinic. Garrick met with Dr Paul. O'leary he recounted the onset of his illness and his current symptoms. Sadly A- Larry and other physicians at the clinic knew exactly what he was describing. And it didn't sound good everything lined up with. What Sharko had documented over seventy years before the problem was there were many other neurological diseases that fit gehrig's description to and there was no test for LS that meant. The doctors had to rule out other conditions. I guarantee spent nearly a week in Minnesota undergoing medical tests his physicians determined. It wasn't Parkinson's disease or Huntington's disease crossing off more possibilities every day. The list of what it could be was narrowing down to the worst possible outcome. It only took a week to get through all of the tests on June nineteenth nineteen thirty nine GHERIG's thirty sixth birthday. The doctors inform the famous ballplayer of his diagnosis garrick. Sad is he learned the grim news he had. Ls while this disease was rare. It affected over thirty thousand Americans a year and there was no cure. Garrick would just have to let it run. Its Course Dr O'Leary whom Garrick would go on to form a relationship with said that in many cases patients only made it three years before they died from the illness garrick was at a loss for words. He always been a hard worker and he was used to his efforts paying off. He didn't like that there was nothing he could do. Now then O'Leary gave him even more bad news. He had to stop playing baseball altogether. While the activity wouldn't aggravate the condition GEHRIG was putting himself at risk. Every time he set foot on the field his reaction times would only get slower and a one hundred mile per hour line. Drive at first base could do serious damage. Garrod left the Mayo Clinic in quiet despair but he trusted O'Leary's prognosis and knew there was no point fighting it. All he could do was make the best of his final years and say goodbye to the sport he loved on June twenty-first the Yankees announced gehrig's diagnosis and retirement to the public fans and sports lovers. All over. The country were shocked and saddened. Garrick was a hero. Things like this weren't supposed to happen to men with nicknames like Ironhorse to soften the blow the team announced that they beholding and appreciation day for Lou Gehrig on July fourth. Nineteen thirty nine fans filled Yankee stadium to give Gehrig a proper sendoff. Some of his old teammates like Babe. Ruth were in attendance before the game started. Gehrig walked to a microphone in the middle of the field to give a farewell speech. He said fans for the last two weeks. You've been reading about a bad break got yet today. I consider myself the luckiest man on the face of the earth. There was hardly a dry eye in the house as Gehrig left the field for the last time he was optimistic even though his prognosis was in bright he was going to make the best of the time he had but he didn't have long at all. It was only two years later on June second. Nineteen forty one. That Lou Garrick died in his home in New York. It was a sad day for sports. Fans all over the country but the famous ballplayers fate wouldn't be in vain. Gehrig's death brought a pronounced awareness to a LS. He inspired countless donors and activists more money than ever before was funneled into charities and research across the Globe. Now better funded and supported. Physicians threw themselves into their studies. The race was on every day. More people were diagnosed with LS. The scientists had to find a cure and fast Lou. Gehrig wouldn't be the only famous name to suffer the disease before long a ls victims range from Johnstone. The creator of Sesame Street to physicist Stephen Hawking as well as countless ordinary people MOMS DADS SIBLINGS. New Research was their only hope for survival. But perhaps the answer lay in simple bucket of ice..

Lou GEHRIG Lou Garrick New York Yankees O'Leary Minnesota Nineteen Twenties Mayo Clinic Florida New York City Joe McCarthy Gary Lou Yankee stadium A Stephen Hawking Dariga Eleanor
"gehrig" Discussed on Medical Mysteries

Medical Mysteries

09:59 min | 1 year ago

"gehrig" Discussed on Medical Mysteries

"To breathe her muscles in her chest barely had any strength to rise up and allow more Aaron. Each breath came in shallow and raspy. Her time was drawing to a close and she knew it slowly over a couple of days. She succumbed to her illness and passed away. Her death was heartbreaking but charcoal was used to these sorts of tragedies almost all of his patients died but he did his best to bring meaning out of their loss that meant learning everything he could even after death marines body was brought into an operating theatre where Chicago ended. Assistant performed an autopsy. They made an incision along her sternum and cracked open her chest cavity to get a look at our vital. Marie was thin from malnutrition but her heart and other vital organs appeared to be in fine shape with all of these preliminary observations made. Sharko moved onto what really interested him. Her spinal column in eighteen sixty five. There was a huge debate about how the nervous system worked. No one doubted that. The spinal cord was important to movement. But they still weren't exactly sure how everything worked together. Sharko meant to change that. Maurice Body was repositioned so he could get a better look at her spine. Her bone structure looked fine but he wanted to get a look at what was inside her spinal cord. He carefully cut into the spinal column which is composed of thirty three vertebrae. The Vertebrae are protective coating for the spinal cord. A bundle of nervous tissue that runs the entire length of the backbone. Sharko cautiously saw through bone. Each pass had to be shallow and sure if he cut too deep. He risked destroying valuable sections of the spinal cord after what felt like ours. Sharko managed to cut away the spinal column. He finally had the chance to examine the exposed. Neural tissue and there. He was astonished to Find Grace. Streaking lesions lesions are any kind of cut break or abnormal tissue. And they're not always a sign of illness for example. The Mayo Clinic notes. That scars and birthmarks are both kinds of lesions except healthy. People usually don't have any markings or visible damage to their spinal. Cords Sharko was certain that these lesions had caused Marie symptoms. This discovery was revolutionary. He sketched the abnormalities and described them at length in his records. He noted that they were clustered on the lateral column in simple terms. If you were to look at the spinal column from above you'd see it's shaped like a thick ex. There are two branches in front called the Anterior Horn into in the back. The Posterior Horn on either side of the ax is the lateral calm. Murray's lesions were mostly on the lateral column of the spine. This was difficult to explain Sharko. Couldn't imagine what sort of disease would damage the front of the spine while leaving the middle and back alone. He was an uncharted territory. The field of neurology was still in its infancy and there weren't any firm theories about what lesions on the spinal cord could mean. Sharko assumed the lesions had caused Merisi illness but he knew that one individual symptoms didn't make for a solid theory. He needed to repeat the findings and that meant dissecting another person who died of the same condition for the next four years. Sharko kept seeing patients studying and documenting countless conditions. But all the while he kept an eye open for someone with symptoms that matched. Meri's however the illness was apparently very rare because he struggled to find patients who fit the profile not until eighteen sixty nine. When Sharko had another breakthrough unlike Marie who gradually lost her mobility this patient had presented with paralysis as a child but when Sharko performed his usual he noticed that this person had the same kind of lesions on their spinal cord. The one difference they were on a different part of the spine the anterior horn or the front part of the eggs. Once again Sharko didn't know where the lesions had come from or why they clustered around one spot but every new piece of evidence helped him get closer to an answer from these. Two examinations Sharko developed a hypothesis. He theorized that the nervous system had two basic functions. I the brain sends signals to the spinal cord second. The information traveled from the spinal cord to the rest of the body. At least that was how things worked in a healthy person but if those signals got interrupted say by lesions on the spinal cord then a person wouldn't be able to move correctly the location of the lesions determine the specific nature of the patient's impaired mobility in eighteen seventy four. He published his studies and dubbed the New Disease Amaya Trophic lateral sclerosis or a LS. He was the first doctor to show a detailed blink between these symptoms and underlying physical condition rather than purely a psychological one. Despite his revolutionary findings Sharko was still missing a crucial piece of the puzzle. He didn't know what had caused lesions so the next step was to look at which traits his patients shared to see if he could find common cause both of his patients had been women but Sharko didn't think gender played a role in their illness after all he was working at the women's wing of the hospital so it was possible there were male patients. He just wasn't seeing after further research he also ruled out race as a potential factor. But he still didn't know what did cause L. ASS and without knowing the origin he couldn't come up with a cure instead he had to rely on and error. Sharko was a big proponent of using hypnosis to treat his neurological patients and he was having limited success but only in those that had what we know as psychological conditions sadly since patients with LS lesions on their spinal cord. Hypnotherapy did nothing for their symptoms although Sharko didn't know how to treat them. His discovery of the spinal lesions had been huge at the end of his life in eighteen ninety three. His findings were widely accepted all over the world. Since he'd been so diligent with his notes. Physicians knew the symptoms to look for to diagnose patients with AOL S. Most patients were like Marie. They'd start out feeling fine but then slowly grow weak over time. They lose control over their muscles and deteriorate until they stop breathing other patients lost control over their voluntary motor functions. While they are weaker they'd find themselves shaking or spasm ing some would start laughing or crying unable to stop doctors could diagnose from these symptoms but they still didn't know exactly what the lesions were doing nor could they figure out the significance of their location on the spinal column. Why did they appear in different places and triggers such different symptoms while they looked for solutions? Their patients were dying. Doctors remained powerless to stop the condition on top of that the general public was mostly unaware of the illness. So there was little pressure for more research but that was all about to change in the spring of Nineteen thirty nine. One of the greatest baseball players of all time was diagnosed with a LS and he changed the dialogue around the disease forever. Coming up all star first baseman Lou GEHRIG becomes the first face of LS now back to the story in eighteen. Seventy four forty eight year old. John Martin Sharko. A world renowned doctor published the first ever study on a Maya traffic lateral sclerosis or ls. The condition caused by lesions on the patient's spinal column leads to slow muscular deterioration then ultimately death while Dr Shark who discovered the illness. He was unable to figure out what caused the lesions or to cure them but he laid a groundwork that countless neurologists would follow over fifty years of study. They were frustratingly few breakthroughs and by the early twentieth century. There was still no treatment or cure while the disease was well known within the medical community the vast majority of people had never heard of it. This relative obscurity made it nearly impossible to get proper funding for further research. But that was about to change thanks to a celebrities diagnosis.

John Martin Sharko Marie Anterior Horn Sharko Chicago Aaron Posterior Horn Mayo Clinic Maurice Body Lou GEHRIG baseball Meri Dr Shark Murray Maya Merisi AOL
"gehrig" Discussed on Medical Mysteries

Medical Mysteries

02:00 min | 1 year ago

"gehrig" Discussed on Medical Mysteries

"Forever..

"gehrig" Discussed on Medical Mysteries

Medical Mysteries

01:37 min | 1 year ago

"gehrig" Discussed on Medical Mysteries

"More palpable at the New York. Yankees facilities fans clamored to get a look at the reigning World Champs. They included Joe Dimaggio Vernon Lewis Lefty Gomez and none other than the Ironhorse himself Lou Gehrig. Derek was excited to be back for another year. It was a chance to extend his regular season. Starting streak after more than two thousand game straight GEHRIG meant to finish his career on top but as the spring season wore on he felt off. He was getting fatigued easily and his once. Formidable batting power was gone each. He stepped up to the plate. He relaxes his grip on the Bat. He kept his eye locked on the Pitcher as the ball. Shot through the air. He tracked its path toward the strike zone. He cocked his arms back and Swung. He regularly made perfect contact. But which should have been a line drive was instead a soft blooper that landed just beyond the infield thirty five year old. Gehrig couldn't figure out what was wrong. Sure he was getting older but his routine hadn't changed since last season he couldn't have lost his edge over the course of one winter could he? He didn't know it yet but he'd been struck by a little understood incredibly rare illness and it was about to get worse. Gehrig only had a few games left in his career and in a matter of months he'd have to say goodbye to baseball.

Lou Gehrig Lewis Lefty Gomez Yankees Joe Dimaggio Vernon New York Derek baseball Ironhorse Bat
Report: 34 Used Vermont Aid-In-Dying Law Over 2 Years

WBZ Morning News

00:33 sec | 1 year ago

Report: 34 Used Vermont Aid-In-Dying Law Over 2 Years

"People in Vermont are now taking advantage of what is known as Vermont aid in dying law the report just released founder of the thirty four cases twenty four were people suffering from cancer for we're due to Lou Gehrig's disease a LS three would due to degenerative neurological diseases and three would do to other events Vermont law requires the health department to release the report every other year with statistics on how many people took advantage of the law to help end their

Vermont Founder Cancer Lou Gehrig
A final chilly plunge for man who boosted ALS ice bucket challenge

Family Financial Focus

00:13 sec | 1 year ago

A final chilly plunge for man who boosted ALS ice bucket challenge

"Dead supporters of the frailties take one last chilly plunge for the former college baseball player whose battle with Lou Gehrig's disease helped inspire the ALS ice bucket challenge Freddy's family saying the eighth annual plunge repeat at a beach in Gloucester will be

Lou Gehrig Freddy Gloucester College Baseball
Last Fundraising Plunge for Ice Bucket Challenge Inspiration

Rush Limbaugh

00:35 sec | 1 year ago

Last Fundraising Plunge for Ice Bucket Challenge Inspiration

"News today marks the end of a frigid and very successful fundraiser heat Freddy's battle with Lou Gehrig's disease helped inspire the ALS ice bucket challenge supporters taking one last chilly plunge for the former college baseball player the phrase family says Saturday's annual plunge for Pete a good harbor beach and Gloucester Massachusetts is the last the former Boston College baseball player lived in Beverly a suburb north of Boston he died December ninth after a seven year battle with a alas or any atrophic lateral sclerosis the ice bucket challenge went viral in twenty fourteen raising more than two hundred million dollars for

Freddy Lou Gehrig Pete Beverly Boston College Baseball Gloucester Massachusetts Boston College Baseball
Peter Frates, known for ice bucket challenge, laid to rest

WBZ Morning News

00:59 min | 1 year ago

Peter Frates, known for ice bucket challenge, laid to rest

"A final goodbye Brady's the former B. C. baseball star in Beverly native who helped raise over two hundred million dollars with one of the most epic campaigns of all time raising money for A. L. S. the ice bucket challenge join the people bring attention to live Gehrig's disease by taking the ALS ice bucket challenge to about a great cause and I want to get involved with the full you have twenty four hours to accept the ice bucket challenge and a glimpse of celebrities politicians millions of people across the globe taking part in the ice bucket challenge over the years meantime a funeral procession will begin this morning on the north shore and wind up on the campus of Boston College for his funeral service WBZ's Chris farmers in Chestnut Hill this morning Ural services will be held this morning at Boston College and say the glaciers of Loyola church the cathedral that greets all

Brady Gehrig Boston College Chestnut Hill B. C. Beverly Loyola Two Hundred Million Dollars Twenty Four Hours
Pete Frates, Who Promoted the Ice Bucket Challenge, Dies at 34

Afternoon News with Tom Glasgow and Elisa Jaffe

00:37 sec | 1 year ago

Pete Frates, Who Promoted the Ice Bucket Challenge, Dies at 34

"He was the former college baseball star who is credited with raising hundreds of millions of dollars for ALS Freddie's died this week at the age of thirty four British grew up in suburban Boston where he excelled at sports eventually playing so our field for Boston College in playing baseball overseas after returning home he was diagnosed with a LS also known as Lou Gehrig's disease back in twenty twelve when he was just twenty seven two years later Frehley's championed this the ice bucket challenge became a viral sensation with celebrities an entire sports teams taking part two hundred and twenty million dollars it's been

Als Freddie Boston Boston College Lou Gehrig Frehley College Baseball Twenty Million Dollars Twenty Seven Two Years
Ice bucket challenge inspiration Pete Frates dies at 34

AP News Radio

00:41 sec | 1 year ago

Ice bucket challenge inspiration Pete Frates dies at 34

"His family says Pete Freddie's died peacefully in Massachusetts the former college baseball player was diagnosed with Lou Gehrig's disease in twenty twelve the ice bucket challenge got started in twenty fourteen Brady says family got involved the challenger exploded on social media I am doing this in honor of key phrase videos were posted online celebrities took the ice bucket challenge including Donald Trump before he became president it raised about two hundred twenty million dollars worldwide feed a LS in a twenty twelve interview Pete Frady said the man upstairs has a plan for me there are people out there that don't have my support system or my advantages and I want to help them I'm a Donahue

Pete Freddie Massachusetts Lou Gehrig Brady Family Donald Trump Pete Frady Donahue College Baseball Two Hundred Twenty Million Dol
How to Look Forward to the Next Recession

The $100 MBA Show

09:12 min | 1 year ago

How to Look Forward to the Next Recession

"Welcome to the NBA show. Your Business gets better with every episode. That's why we deliver daily ten minute business lessons for the real world. I'm your host your coach. Your teacher Turow Mars and home. I'm also the CO founder of the Hundred Dollar Mba. A couple of visits training and community online and each episode is a guest teacher episode. Today's is guest is Jonathan slain. And he'll be teaching you how to look forward to the next recession. Jonathan's lane is the founder of recession DOT COM amazing eurorail author keynote speaker then thought leader when it comes to preparing your business for the recession no fear it just be prepared. It's just a matter of time time for the next recession. Recessions come in different forms as Jonathan will explain but the most important part is being prepared being ready so you can actually grow intercession. Jonathan has a lot to cover in today's lesson. So let's get into it. Let's get down to business. The show comes from Amazon. Logistics Amazon Logistics has a new program for leaders who want to build their own a full time package delivery business. Get access to Amazon's logistics training and technology and start building a team of motive drivers in your community to learn more about becoming an Amazon Amazon delivery service partner go logistics dot Amazon Dot Com ups and downs in Your Business in the economy are inevitable than those who are prepared for those who are able to not only survive but strife we brought on Jonathan slain to show US exactly how he shares his own personal story ory on how to actually thrive in a recession. How to be prepared to make sure you're not caught off guard so I'm gonNA pass it to Jonathon now? The cheese you his guests lesson. But I'll be back with my takeaways and to wrap up today's episode so for now taken away. Jonathan Buckle up. My name is Jonathan Jonathan slain in today. I'll be teaching you how to look forward to the next recession. It's time to rock my story. Is that right before the great recession in in two thousand eight I partnered with my brother in law to start opening up gyms fitness businesses. You know like personal training studios. We open new locations locations and we grew very fast. Our studios achieved new franchise records every year. We have the most personal training sessions ever in the history of the franchise is we had the most locations ever in the history of the franchise. We couldn't miss. We grew and grew and grew that is until we ran into into the great recession. Looking back I'm GONNA let I'm not this audience in on a little secret. Nobody wants to pay for personal training training in a recession and worse I didn't have a plan for what to do when the recession hit so I spent the first couple months of the recession curled up in the fetal position in the corner of my office and the other hand Paul My business partner and Co author who I wrote rock the recession with. He had a plan for the recession and he was looking forward to it. He bought a company and he did very specific things to grow at spectacularly using the downturn is fuel that led to his American Dream Exit poll had picked the HVAC business because he knew that he could leverage HVAC service in a recession. In contrast contrast I was in the personal training business because my brother-in-law happened to be a fitness fanatic and then ended up borrowing a quarter of a million dollars for my mother-in-law our law in order to help us survive the recession and the worst part is I'd ending abroad of the money. All at once I borrowed at twenty thousand dollars at a time. So Oh you do the math. That's twelve phone calls groveling for money. Now I've paid my mother-in-law back since and now on a mission to make sure that nobody has to borrow money from their mother in law in order to survive the next down term. You know right now. The economy's booming unemployment's at record lows consumer confidence. Confidence is at record highs in. Almost nobody has a plan for the next recession. And I want you to be honest with yourself. Are you prepared for the next recession and when I say recession. I don't just mean economic recessions if you lose your job or your biggest customer your in a recession if your five best last employees leave and form a competitor your in a recession if your partner embezzles from you you. My friend are in a recession. But don't worry no matter why you're in a downturn it's possible for you to rock the recession and that's what we're talking about today so. Let me get specific. Let me tell you exactly how how to get ready for a recession. If you have a pen pick it up now and get ready to write this down. Step one are you ready the first first step in building. Your recession plan is to do a credit check on your mother-in-law all right I'll series says the first step in building recession session plan is to assess where you and your company are so pollen. I developed the recession gearbox model to help business leaders and you see the four four gears. The Paul used to accomplish his American Dream Exit from his company. First Year is to assess your situation sucking dearest attuned up your business and personal personal life to prepare for a recession third gears to race which means getting your company culture healthy measuring productivity of your employees rooting out profit said Fade fourth dearest. Hit The gas accelerate. This is where you're going to start to capitalize on all the opportunities. The recession brings in. Finally there's the emergency emergency break. which is there in case all else fails? You'll have a backup plan to prevent catastrophe. Now I WANNA take a second pass through this model highlighting tactics that you'll employ in each gear so for first gear. You're going to assess you always start here. You need to know how the economy works at a basic level and you need to understand the economic cycle because it always includes a recession. It's like the seasons of the year spring summer fall winter. Sometimes when arrives late but it always arise in terms of the economic cycle. Winter is always coming in first gear. You assess where we are in the economic cycle. This is also the gear that you're in when he used the recession readiness assessment to understand. How prepared your company and you are for the next down term in the scary your benchmarking your preparedness hardness from there? It's all about evaluating what you learn understanding how much opportunity you have to use the next recession as leverage for massive growth and gathering gathering the documents. You need the shift into second gear. If you want to follow up on first year you can go to recession dot com slash ready. That's our website and you can take the free recession readiness assessment. There takes about five to ten minutes once you're done with first year assessing now you're gonNA tune this is the gear where you perform stress tests to figure out where your personal and business finances are strong where they're weak. You tighten up your business and personal smell affairs in an unemotional way. And then you'll emerge confident for the next year you'll have conversations with your banker to figure out your line of credit. You want to increase your line of credit now before were in a recession before you need it because banks liked to loan money when times are good They don't like to loan money when times are bad. Perhaps my favourite tip of the entire lesson. We're doing today. Is that now to day. Day is the perfect time to ask your banker to reduce lower or cap. Your personal guarantees if you have them on corporate or personal data at Your Bank. They they aren't going to do this. One Time Sir are bad when we're already in a recession. They're going to let you reduce cap. Your Personal Lou Gehrig's disease now when times are good and sometimes you may have to switch banks to accomplish the skull but I think the effort of finding a new Bank of switching banks is certainly worthwhile and it doesn't cost you anything for you to simply ask your bank or for you to shop. Your Bank With with other institutions banks are so hungry for new business right now that it's entirely possible for you to reduce or CAP. Your personal guarantees but times are so. Oh good that most people just don't think to ask so. Please take me up on this huge opportunity. If you have a loan with personal guarantees okay. Once it's worth through second gear now we're GONNA shift in third year race. This is the gear where you're going to be Improving your business improving your company's culture measuring during employee performance measuring Labor

Jonathan Jonathan Your Bank Partner Amazon Amazon Logistics Jonathan Buckle NBA Turow Mars Co Founder Hundred Dollar Mba Founder Lou Gehrig United States Jonathon ORY Paul Twenty Thousand Dollars Million Dollars
Speed vs. Safety: Rapid Approvals from the FDA

Sounds of Science

09:46 min | 1 year ago

Speed vs. Safety: Rapid Approvals from the FDA

"Why is the FDA's rigorous testing so necessary. Well I I think you're aware that a lot of drugs fail From safety concerns we all know about getting sleepy with antihistamines. Or you know that's the actual aside side effect that comes from the action of the drug on the brain. That's at the senior centers that we would like to counteract allergy. So that's what we call pharmacologic based aced toxicity. It's an effect actually on the target. But it's in a way that we don't want it to act GOTCHA. So as we're working on very new drugs we often don't understand like where there's receptors are in God or the brain or the immune system. There's a lot of things we don't understand about the basic mechanisms of action of disease and there's lot of things that we don't understand sometimes about where the receptors are in the buddy. I mean it seems great. Yeah but that's why. I'm kind of glad if my original training and classic Comic Anthology Because you have to ask questions okay. where else is the receptor? Who else could hit end so? FDA trained to think about those nightmare scenarios of what it could do that. You don't want it to do right and ask those hard questions to make sure that we have the checks and balances right a lot of the early drugs That were used in AIDS. Patients Cause Peripheral neuropathy and that wasn't shown very well in the animal models models but it caused intense pain in the patients at the same doses that was needed for the virus. It wasn't until later that we got the protease inhibitors that really counteracted the road. And that's the basis of the lifesaving therapies that we have today I was really fortunate to be. FDA during that time when the protease inhibitor came through so switching gears a little bit what is personalized medicine. When it comes to patients like for example adjacent armstead and meal Amac? I understand that Jaycee is a twenty five year old with Lou GEHRIG's disease while meal is a young girl with batons disease who have both recently benefited from personalized medicine. He I think we have come to the place in drug development where we understand a lot more about genetics of disease so so yes switching away from viruses and into genetic Madison we have a lot of inborn errors when we learned that there is an inborn Gene that was missing in a patient has always been there born like that and as soon as we can diagnose them and with that replacement gene product or the enzyme of interest interest. We can save their lives so. LS has also been learned to be a whole series of different mutations responsible for LS Um and so you have to look at those different subsets according to their genetic diagnosis. But we also know that Batten's disease is a specific mutation and there's also something like fourteen different forms of Batten's disease that are mutations in same pathway that result in the same type of phenotype of neurological article degeneration some earlier some younger and some an older kids or adults in the case of Mula. She has two mutations that are different on both of the wheels that caused the dysfunction of a particular protein. Batten's disease six seven and there's only a handful or double handful of kids worldwide. They're known to have that particular subtitled batons and Jaycees case she has a very aggressive form of al it lasts called F s mutation and it has a particularly bad course people with F.. US typically sadly succumbed LS typically approximately a year. Because it's so aggressive. It's very hard to intervene soon enough. And there has never been a medication that could actually address the fundamental gene problems in these two cases so we need to design whole new the truck when we find the particular mutation and it turns out depending on the molecular biology and that control mechanisms around them. A tation some all of them are amenable to go nuclear type therapy and both of these girls have been their particular. Genetics have been amenable to A strategy she of using nuclear tight enter equally sadly we did not know that. JC had this particularly bad ale ass us until she was twenty five. Her family had lost her twin sister at the age of seventeen and Alex add add. Actually he contracted the symptoms of L. S. at age eleven so the two girls were identical. They had the same mutation but one got symptoms at eleven on the other at twenty five. JC I guess Through some grace right. Her symptoms arose during time in which a drug was already available in unaccompanied show that happened to be appropriate for her. So I understand and that in this case she got lucky. Well in a way because the drug already existed otherwise we couldn't have intervened quickly enough. Yeah it was an act of considerable effort on the part of the patient advocacy group project. LS The head of Columbia University's LS LS center. Dr Neil Snider in the company who originated the drug and all of us that were helping around the sides trying to support like an exoskeleton including Charles forever and I was helping with the regulatory strategy and also trying to make sure that the drug that was chosen was actually appropriate to the most expedient animal model so as a result of that we were able to put together a very lean and mean I N D for JC and get her approved through the FDA. I have to say. FDA was understandably cautious but when they heard her situation detail and how she'd lost her twin sister the understood of course about a few and they made a lot of exceptions to the usual toxicology regulations. Well I know that she had been she and her family. They had been advocating pretty publicly for a while up until it was approved. I if I'd been in her mom shoes I would have done the same thing called. She lower local congressman. The Stephen King and there was actually quite a response. In Congress. There is a bill that was put forward to ask. FDA to move expediently for JC. I don't know that that had specific impact but just to say that they got some considerable public discussion. And how Camilla's case different in her case Tim you At Boston Children's Hospital recognized that her condition was suitable for an exon skipping being drug very similar to Isis Been Raza and he was able to use a similar backbone and design a drug from scratch within several months it was quite remarkable global. We've done the testing for it and then we've Were able to get started with just a acute data and then I designed a type of a program in which we would update the FDA very regularly on the progress of the toxicology studies so that we could extend her dosing and again. FDA's group group that does an enzyme replacement was wonderful. In working with us to customize that I approach how do you envision cases like these being handled in the future after all not everyone. Everyone has a congressman. That's willing to go to bat for them. Like Jaycee did not. Everybody should take one. There's definitely a sea-change coming is really exciting. And it goes back to the changes brought about by the AIDS patients who identified that they were an extreme unmet medical. Need we see the finalization of the L. S. guidance. We see a lot of guidances have come out on rare disease from the agency in the past twenty four months. And I'm very excited about this because we're really getting to the place where we custom tailor the amount of upfront non clinical research. That has to proceed to human trials customize. That the patient's situation well do you think that each was going to require its own uniquely designed non clinical research at will or will there kind of. Okay you're not gonna be able to have like a standard version that works for most Aso's typically called platform toxicology in kind of a dream. Right now when you look across all a good nuclear tides you find out remember. I mentioned early in this talk about the pharmacologically driven toxicity. Let's say there's another place in the genome that has has a similar sequence. We end up having the drug acting by its intended action bit at the wrong place which is an off what we call an on target but unwanted toxicity existed that could arise by modulating genome which is a little scary right to put something into the spine or once. You invoke gene therapy. What's done is done so you need to have really careful toxicology evaluations that look at the animal as if it were a miniature clinical trial? And you know you're basically siklie handling the animals has patients and so we get as much information as we can vary from each particular experiment and try to make sure that Ed's translation Lee accurate for predicting patient risk. We need the parents to know that right. If if you were me. Resigning are up to our child. An an in-and-out shoes

FDA Congressman Jaycee Batten Protease Inhibitor Ls Ls Center Peripheral Neuropathy Lou Gehrig Dr Neil Snider Aids Alex L. S. Stephen King Congress ASO Camilla ED
Walk to defeat ALS

Drive Time Sports

01:00 min | 1 year ago

Walk to defeat ALS

"It and on the ground and it's what we signed when our soldiers are deployed to protect our freedom abroad but now the bravest men and women among us our approach on the ground military veterans are twice as likely to fall victim to a LS the fatal neuro degenerative disease that robs them of the power to use their lax hold someone close a solid meal simply say I love you before ultimately losing the ability to bring most often remain aware and alert to the world around them as their bodies gradually shut you don't need to know about red with a alas to no it must be stopped the those affected your support join the A. L. S. associations wall to defeat a LS to help us find treatments and a cure for Lou Gehrig's disease but the walk you you want to defeat a LS dot

Degenerative Disease Lou Gehrig
"gehrig" Discussed on KQED Radio

KQED Radio

01:35 min | 1 year ago

"gehrig" Discussed on KQED Radio

"The Beatles had just made their first appearance on The Ed Sullivan Show February ninth nineteen sixty four they're Sullivan trying to introduce caps and there's a gallery full of kids all screaming for a Beatles encore. very in may nineteen twenty five a New York Yankees baseball player was benched bringing to an end his record breaking streak less than a month later the player who replaced him was himself replaced his replacement immediately began his own streak and eventually broke the same record what is that all about Johnny bench. the the Yankee that that was benched was that was is that Lou Gehrig Lou Gehrig was the one who replaced the one who replaced the one who was benched. so Lou Gehrig replaced Pete rose. it wasn't the Yankee rather than naming random baseball players. I've run out of the ones I know. there was a player who had a streak broke a record than he was benched replaced by somebody else a month later somebody replace that guy and started his own streak and broke that same record and Lou Gehrig is the guy at the end of that chain who would've been Babe Ruth and know what's the record you want to know what the record as well what is the record for most can most consecutive games played and longest says you answer..

Lou Gehrig Lou Gehrig Beatles Sullivan New York Yankees Babe Ruth baseball Johnny Pete rose.
News in Brief 3 May 2019

UN News

03:09 min | 2 years ago

News in Brief 3 May 2019

"This is the news in brief from the United Nations attacks in the Democratic Republic of the Congo's Ebola hits North Kivu province. Forced more than one hundred thousand people to flee their homes in April. The refugee agency UNHCR said on Friday, speaking to journalists in Geneva, urinate. She our spokesperson baba Balak said that those displaced facing a desperate situation and access to them as being hampered by continuing violence involving multiple armed groups. It's estimated up to sixty thousand people fled in the past month. It's the result of fighting around commando near the town of Beni. That's an estimated fifty thousand people fled in neighboring Lou Gehrig territory, where the Congolese army was fighting, my militia the Benny area is the epicenter of the worst ever deadly Abullah virus outbreak in Diaz history, which is killed close to a thousand people since last August and infected nearly fifteen hundred here's more from baba Balak fighting continues in southern parts of not Keeble and toward the polish capital of Goma off. On displaced. People are the targets last week five mutilated bodies were found in a river in Masisi territory around sixty kilometers to the not west of Goma. The bodies included those of three children four of the dead were people who had been kidnapped from a nearby displacement site. The head of the UN human rights office or HR stressed on Friday that capital punishment for child offenders is absolutely prohibited. Under international law. The execution of two seventeen year old boys in Iran on charges of rape and robbery High Commissioner for human rights. Michelle Bachelet said the two cases were particularly outrageous because it appears that both boys were reportedly subject to ill-treatment and a flawed legal process. The human rights office urged thirties in Iran, immediately, hold any further executions of child offenders reminding around that it's obliged to abide by the International Covenant on civil and political rights by the convention on the rights of the child Misbash. Colin authorities to immediately commutable such death sentences Mechta before and I mean said I got were fifteen years old when they were arrested and accused of rape and robbery two years ago. The boys had originally denied all charges but related convicted sentenced to death and executed on the twenty fifth of April. The will program WFP announced on Friday that it suspended distribution worldwide a fortified blended food from one of its suppliers the precautionary measure was taken while tests continue to establish whether eating the cereal could be linked to an illness outbreak in east Africa. The combination of Mazel wheats blended with soya beans and fortified with vitamins and minerals is used by WFP and partners to prevent malnutrition, especially among women and children, according to medical center and hospital records three people died in two hundred ninety three were admitted for treatment in the caramel J region of northeast Uganda in March and April after eating the super serial today. It's more than two thousand four hundred food related laboratory tests are being conducted. Including for Mike, O toxins, heavy metals pesticides microbe contaminants, but the root cause of the problem has not yet been established might wells UN news.

United Nations WFP Baba Balak Goma Iran Rape Robbery Congo Michelle Bachelet Unhcr Lou Gehrig Geneva Uganda Congolese Army Masisi Mike Benny Diaz
Erdogan says Turkey will boycott US electronic goods, including Apple’s iPhone

Bloomberg Daybreak: Europe

03:58 min | 2 years ago

Erdogan says Turkey will boycott US electronic goods, including Apple’s iPhone

"Lira is resuming declines as. Measures announced by the central Bank. Proved insufficient to stem around in the currency this as president air to on shows no sign of backing down in. A standoff with the. US which sanctioned to ministers in his government in a spat over the detention of an American pastor, in Turkey for more let's go live to stand board daybreak Middle. East anchor Yousef Gamal El Deen is standing by Yussef let's kick it off with the political developments I guess overnight since president air to one attacked the iphone Matt stories, been moving fast so we had the. Speech from from president as you pointed, out where he threatened that. They would, be moving away from the United States in terms of that trade relationship he. Specifically mentioned tech the US is Turkey's. Large four fourth largest trade, partner after, Russia and China so, it's not an unimportant relationship and then you had the Russian Foreign Minister in town for good measure. For ideological fix. If you wanted, to send. The signal across the pond. We hide the US response in the forms of their in the form of their spokesperson who said we believe Turkey. Needs to do the right thing and they're gonna come through with that and now this the last few minutes Matt Turkey raises the bar once again we understand that now they've raised customs tax on some US goods. Including vehicles so you're looking at twenty two items mobile. Phones are. Not included but again it does. Include rice alcoholic beverages and one hundred and. Twenty percent on passenger cars and other motor vehicles sixty percent On cosmetics so once again after. The clear threats yesterday in his speech here the government following me. Up with, some additional measures and arguably raising the stakes for the remainder of the day. Guys yes certainly raising the stakes aired. On not giving up her. That easily, it seems attention also, turning towards foreign currency bonds cease if that Turkish companies hold run us through the numbers here The conversation there on interest rates is. Not over yet even. Though the, president has made clear that he thinks this is evil and a tool of exploitation domestically there have been more and more voices who are. Calling for tighter monetary policy and it's because of this domestic. Pressure that is growing speculation that the central Bank may move on rates but not necessarily at. An emergency session more likely at its regularly scheduled meeting you mentioned the bonds Bloomberg's crunch the, numbers you looking at sixteen. Billion dollars worth of foreign denominated bonds that are gonna come to you by the end of twenty nineteen the, first, company that's up as. Coca Cola each a check they've got five hundred million dollars in the senior unsecured note that's coming you on October one so this again goes to show that if this is going. To, turn into a debt crisis it's not gonna happen overnight and the. Real damage is going to be done if the lira stay at low levels for prolonged periods of yeah I mean We've already heard of foreign shoppers getting super giant discounts on like luxury items but I wonder, when the tables turn and. Retailer start raising prices have you seen inflation on regular things when you go out to eat Yussef or people, already. Raising prices Not just yet I'd say the majority of the interactions that. I've had, and the. Goods that I've purchased which mind you have not been luxury? Goods just yet basic goods to survive and get through the day here. This bull those remained unchanged with the exception of of fuel prices selectively at certain retail outlets but again you're right the question becomes is how, quickly is that going to change the exchange houses have been very. Quick to. Reprise and. Reprise quite accurately we. Went. Through some of the shopping. Streets and they were offering liras, at quite a realistic great, given, global markets are. Trading that particular play but we'll keep a close eye on that over the, coming days of course

Bloomberg United States Turkey Yousef Gamal El Deen President Trump Bloomberg Matt Tencent Michael Barr UK Tom President Maduro Wembley Stadium China Twitter NFL Matt Turkey Ruth Honus Wagner Venezuela Intel Ruth Gehrig
"gehrig" Discussed on Newsmakers

Newsmakers

01:33 min | 3 years ago

"gehrig" Discussed on Newsmakers

"All too well the socalled lou gehrig's disease and it's been a great outpouring from the baseball community in the time since you know donations made by players to the fight against a ls and of course a scotty spent a few days at home with his family away from the oakland as he came back on tuesday night join them at fenway park and his first bad back here's what happened stephen piscotty back with the ball club the celebration of life or as mother gretchen that took place yesterday in the east bay how about that steven scotty baby is gone the scotty family and pleasant if you're standing in cheering or maybe a little tear we know why he touches his heart said and looked up the skies and congratulations steven fiscal joe homerun number three four scotty the more emphasis than the other one so that doesn't give you goosebumps richard nothing well yeah i think they're just things that have happened that you can't put into words in this whole process of john mosaic trading him to billy being so he could be so stephen could be near as mom and then the standing ovation he got in oakland last weekend when he he came back before taking the bereavement leave you know he was he was standing at home plate crying and then to his first game back they had a home run these are moments that you really can't put into words and it's just it was it's just you can't like you said you watch it you know your touch by.

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"gehrig" Discussed on WHYR 96.9 FM

WHYR 96.9 FM

01:42 min | 3 years ago

"gehrig" Discussed on WHYR 96.9 FM

"To help stephen hawking experience weightlessness he wanted to fly in space and to really show that he can do this given the incredible challenge that he has with his body with a ls lou gehrig's disease and the essential basic paralysis a the majority of his body but he's wanted to fly ultimately a fly out into space so the first step has for many wannabe astronauts and the actual astronauts is to experience weightlessness in something called the parabolic flight where airplane is flown way up to about thirty thousand feet and then gently arcs over descends down to twenty four thousand feet in about thirty seconds and in that time but people inside experienced says were passing through the gravity field of earth is just as if we were in outer space and so hawking wanted to do that i think both for the ability to demonstrate that people with body challenges like his can do it but i think also fun the guy was just totally excited about so many things you know we heard all these stories in the past week since his passing about heating such a jokester and loved just enjoy things and so wanted to have fun too and that was peter offered to him through zero g and asked me to help out in working with teen to enable hawking to do that so before we go on i must say how incredibly envious i am not only did.

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"gehrig" Discussed on First and Last

First and Last

01:54 min | 3 years ago

"gehrig" Discussed on First and Last

"Ahead of berg is wsb was the police holed up gehrig's blows watch the glib mix places like yes i gotta oh that is a nice caglar brother the corner like a fullgrown added and did it get it right either run y'all how is we that was one of the best of the best thing that ever seen on jeopardy deputies for the causi clearly also uh i don't know if you notice the family feud video does dropped by jay z it was directed by eva diverting a but i mean i am sorry guys i have zero clue about what happened on this video because i don't i'm a spotify reviews take every day no iron more armor titled out two i'm not pain any that you could tell me all the qualities better i got i'm already pain for an article has literally two or three good did you see the video um i actually just cancelled my title on the seventh because that's when the free trial was over i can only did see blue he was president like 2050 in the in the video that's crazy i'll have title so okay i appreciate everyone in this room for not kowtowing to jay z and his music so you can exactly who it on youtube way oh i didn't know that yet a minute long preview so can kind of get the plan an preview like i wanna watch the whole thing because you know they're they're little videos and obilike movie no i'm going to wait for twitter to come out with it that's true twitter be break i always come third for dinner breaks relationships have raise no reason every day tj you've been amazing thank you for joining the plug it before you go we want to know who is the connecting your life who's the plug the plug in my life.

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"gehrig" Discussed on RobinLynne

RobinLynne

01:41 min | 3 years ago

"gehrig" Discussed on RobinLynne

"Natural disaster varying degrees lee indonesian flaws paying jobs be car no no good me i mean the king mm me gehrig's disease five ooh two ooh europe can the so lead yes thing with those.

gehrig
"gehrig" Discussed on RobinLynne

RobinLynne

01:41 min | 3 years ago

"gehrig" Discussed on RobinLynne

"Natural disaster varying degrees lee indonesian flaws paying jobs be car no no good me i mean the king mm me gehrig's disease five ooh two ooh europe can the so lead yes thing with those.

gehrig
"gehrig" Discussed on The Dan Le Batard Show with Stugotz

The Dan Le Batard Show with Stugotz

01:54 min | 4 years ago

"gehrig" Discussed on The Dan Le Batard Show with Stugotz

"And you get a hold of all the artifacts the lou gehrig's glove babe ruth that uh the ted williams stuck you literally get the hold it in your hands you've got to put this white gloves on uh but that's a very cool this well then so we've got big things uh on the four big board we've got a smart things on the grant thornton many board we just added a really cool royal caribbean cruise uh for seven nights tell me bahama throws in a really nice uh i'll fit through uh to people and a travel pack luggage and then a case of a rum on that trip up brute gall rumself there was that there's something for everybody our joined the marlins foundation for the twelve th annual fox sports florida fantasy auction gets night six thirty beds can be placed in person or over the phone if you want more information visit marlins dot com slash fantasy a argued dallas my idea on your social media days to read more critical tweets i want more critical tweets and the broadcast i think those are funny are they not allowing you to do that no i i'll play it i did you hear last night show that i'll i was here last yet but i felt a couple of nights ago you read something that was pointed and i thought it was funny and i took inventory of it yeah i do that on i would i'll be honest with you the ever it went from email twitter we get lat comprehensive questions or tweet that are i mean a lot of it is just follow urge the statement a non sequitur but i think i read a you guys suck last night um in terms of announcers yes it's more of that rats against you need to encourage more courage more i love the airbridge walled city jet saying and and you know fatty mix fatty rights and you guys suck.

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