3 Burst results for "Field Dang"

"field dang" Discussed on The Bio Report

The Bio Report

04:25 min | 1 year ago

"field dang" Discussed on The Bio Report

"Greg. . Thanks for joining US getting so much standing. . My pleasure. . We're GONNA talk about Cartesian therapies, , exuma biotech, , and your efforts to develop rapid point of care delivery of these therapies. . Let's start with Cartesian therapies themselves out of these therapies work today. . Well you know if we were to look at this technology today. . And put it in the context of what we do in science and medicine even fifteen years ago. . The the thought that we could truly have living medicine with genetically modified. . LYMPHOCYTES in the body would have been unheard of it. . And really I think the basic process of taking one cells from the body. . In reprogramming genetically <hes> lymphocytes in returning them back into a patient to retrain those cells to see cancer antigens much in the same way we've done with monoclonal antibodies in the past, , but wiring all that into itself is what is made Carta. . Medicine which has been both exciting in is of course had. . Equally that the number of challenges in in many different areas. . Well. . How are these therapies typically prepared and administered? ? Well it's a complicated process that has. . A tremendous amount of technical skill required as well as logistics so typically. . When a subject is entering into a trial or on therapy for approved medicines, , their blood is drawn and separated into white blood cells and then shipped usually on a plane to a central manufacturing facility where those cells then are taken into a cleanroom, , they are activated their genetically modified they're grown for about. . Fifteen days, , and then they are prepared just like you would with drug. . And then ship back to the site. . So there's a tremendous amount of time that can be lost for patients during this period and then once those cells. . Are received. . Back The patient receives Olympic depleting chemotherapy regimen to kind of make space. . And then the cells are infused and at that point they take off and they're on their own. . These cell therapies have been more successful in hematological answers than in solid tumors. . What why is that? ? Well I. . Think if you look at the history of the Field Dang, , what you will find is that. . One of the principal challenges in building cellular therapies has been it. . They can be incredibly potent. . So in the case of something, , we know very well like CD nineteen, , this isn't a liquid tumor setting those cells with CD nineteen will eliminate. . All targets in the body that express CD nineteen, , and this is found in many lymphomas. . leukaemias. . But the problem is in the case of CD nineteen, , you're eliminating all of the normal cells make CD nineteen, , which are called E. Cells, , and this is tolerable in the case of liquid tumors. . But when you think about the antigens targets that we go after in solid tumors, , those are often expressed in tissues that. . Not Be safe if the immune system were to attack it. . So we've been forced to really take steps back on how well we can make a car for solid tumors to try and make them smarter to help recognize friend from foe. . So the great efficacy I think that you've seen in relapse refractory ael l.. . As well as in diffuse large B. Cell Lymphoma, , and now also I think exciting we in places like multiple myeloma getting that stain level of efficacy in solid tumors has required that people really think about the precision inside of the problem to make sure can get a potent car but also one that is safe. .

carty therapies Greg Frost Carta chairman Olympic CEO
Speeding the Delivery of CAR-T Therapies While Cutting the Cost

The Bio Report

04:25 min | 1 year ago

Speeding the Delivery of CAR-T Therapies While Cutting the Cost

"Greg. Thanks for joining US getting so much standing. My pleasure. We're GONNA talk about Cartesian therapies, exuma biotech, and your efforts to develop rapid point of care delivery of these therapies. Let's start with Cartesian therapies themselves out of these therapies work today. Well you know if we were to look at this technology today. And put it in the context of what we do in science and medicine even fifteen years ago. The the thought that we could truly have living medicine with genetically modified. LYMPHOCYTES in the body would have been unheard of it. And really I think the basic process of taking one cells from the body. In reprogramming genetically lymphocytes in returning them back into a patient to retrain those cells to see cancer antigens much in the same way we've done with monoclonal antibodies in the past, but wiring all that into itself is what is made Carta. Medicine which has been both exciting in is of course had. Equally that the number of challenges in in many different areas. Well. How are these therapies typically prepared and administered? Well it's a complicated process that has. A tremendous amount of technical skill required as well as logistics so typically. When a subject is entering into a trial or on therapy for approved medicines, their blood is drawn and separated into white blood cells and then shipped usually on a plane to a central manufacturing facility where those cells then are taken into a cleanroom, they are activated their genetically modified they're grown for about. Fifteen days, and then they are prepared just like you would with drug. And then ship back to the site. So there's a tremendous amount of time that can be lost for patients during this period and then once those cells. Are received. Back The patient receives Olympic depleting chemotherapy regimen to kind of make space. And then the cells are infused and at that point they take off and they're on their own. These cell therapies have been more successful in hematological answers than in solid tumors. What why is that? Well I. Think if you look at the history of the Field Dang, what you will find is that. One of the principal challenges in building cellular therapies has been it. They can be incredibly potent. So in the case of something, we know very well like CD nineteen, this isn't a liquid tumor setting those cells with CD nineteen will eliminate. All targets in the body that express CD nineteen, and this is found in many lymphomas. leukaemias. But the problem is in the case of CD nineteen, you're eliminating all of the normal cells make CD nineteen, which are called E. Cells, and this is tolerable in the case of liquid tumors. But when you think about the antigens targets that we go after in solid tumors, those are often expressed in tissues that. Not Be safe if the immune system were to attack it. So we've been forced to really take steps back on how well we can make a car for solid tumors to try and make them smarter to help recognize friend from foe. So the great efficacy I think that you've seen in relapse refractory ael l.. As well as in diffuse large B. Cell Lymphoma, and now also I think exciting we in places like multiple myeloma getting that stain level of efficacy in solid tumors has required that people really think about the precision inside of the problem to make sure can get a potent car but also one that is safe.

Solid Tumors United States Carta B. Cell Lymphoma Multiple Myeloma Field Dang Olympic Principal
"field dang" Discussed on 860AM The Answer

860AM The Answer

08:02 min | 2 years ago

"field dang" Discussed on 860AM The Answer

"That they do. Mark Davis in for Dennis Dennis's back tomorrow. And we were together for another one thirty nine minutes. Right back to the calls here. We have another very timely called real quick here is a here's a game that almost any talk show host could play just takes thirty seconds. Little something called did. This really happen. I'll give you something. And you tell me whether you think it real enemy literally just play this wrapped up in sixty seconds. I'll tell you something think to yourself. Yep. That really happened. Or no way, you're ready. Let's see. Let's see. Let's see President Trump. Is it mount Vernon famous historic home of George Washington has President Trump Trump Tower Trump this Trump that President Trump at mount Vernon? Says about George Washington if he was smart he would've put his name on it. You got to put your name on stuff. No one remembers you. That happened or not. Answer is. Yup. Every day. Just gets awesome. So that's why George Washington is trending president. It's just so crazy, George Washington was like the picture of humility. In fact, they were trying to figure out what to call, but call him any refused to be called your excellency or fused to be called your majesty. All the ad was like, the British example. What do we call our guy? And he deflected all of that. He wanted a simple inauguration just don't make it about me. Don't make it about me. Don't make it about me. Well, President Trump is all about making it about him. And you know, what the country gets better or in the constitution against strong borders, fight nicest doing the right things, I could not care less because you know, what Vitas those things I'll make it about him to already so. In the first moments of the hour. I came out of the news break with some research on the fly because found myself 'cause I mentioned the Jehovah's Witnesses who want to do blood transfusions. And I thought what is there something I've missed about orthodox Jew Jewish populations that don't do vaccinations. So looking found this article in the New York Jewish week. No. And then I said what I need. Here's a rabbi. And boom, there's a rabbi ask what you will. And it shall be done on the Dennis Prager show. And so the rabbi was saying that that maybe this is somewhat overstated that that like ninety five percent of orthodox Jewish communities are totally vaccinating. There's there's no huge strain of of orthodox Jewish populations that are vaccine resistant, and I thought to myself. Well, what I need. Now is somebody who's like orthodox and in the medical field. Dang. We are in north jersey. Avi Mark Davis in for Dennis. How are you, sir? Welcome. Good. How are you market? Great. Thank you. Yes, I'm a registered nurse. Next to a little bit more understanding of this. And what the previous caller saying is corrected the orthodox population. In general, have very high has a very high rate of action compliant. However, a small percentage who don't from insularity of community, especially those Williamsburg and rocking county creepy very quick time travel. Bachchan area where the vacuum. Can spread very quickly. Gotcha. But just. I'm part of a organization of nurses to leave the organization has leading a fight to better educate people about that includes compliance that was the next thing. I was going to ask is, you know, you're a medical professional and orthodox Jew is at your burning desire to get into those vaccine resistant communities and say guys get with the program. There's no religious objection to this. So would you say that if I were to find a dozen families that are vaccine resistant their reasons for that are shared with the family of any or of any religious of following of any geography, just got the same pardon me, the same garbage in their head that other anti factors. Do. Many that many it is, you know, the internet nowadays can spread the term very thing. You're mentioning earlier can spread not truth then lies and misinformation very easily. And you know, we have to educate people in a lot of it has to lack of educational wacko understanding, and the I'm not actually on that committee. That's doing the education. But there's they're doing a lot of good work and holding a lot of formative sessions the right now working actually publishing a pamphlet better educated. That would be good at in. Listen, thank you for telling us about it and for being on at a particularly timely moment. Thank you. Appreciate it very very much. And look I've been slinging some some some words such words Ling, and I think I made clear that ill wisdom, I consider it to be for not vaccinating your kids. It's probably important that I say this again is it your right to view. Yes. Is it your right? Not to get your kids. Yes. It is. Should there ever be mandatory vaccinations, though, we even want to Blasios talking about there is not mandatory vaccinations, but like a thousand dollar fine. If we didn't vaccinate the kids, I'm not even comfortable with that. I'm comfortable with the neighborhood school saying your kid can't go here vaccinating comfortable with the pediatrician's office. And you can't be a patient here. If you're not vaccinated, I think this might be an important nuance to point the lost art of nuance ready. I think there's a middle ground between me all in for vaccination. The hard core. Anti vaxxers on the other end and still more in the middle of people who aren't full tinfoil hat wearing anti vacs. But just wonder are these the same vaccinations, we've always gotten do we really need so many so fast so early. Having questions is always good being curious as always good doing research is always good. But there's that word research roof has the gentleman just sick jested. This this internet thing this internet thing may work out. I think it's going to become popular. It is is a gift it is a burden. The internet has made us smarter. In terms of our ability to instantly find I don't even remember what it was like to do this for a living. And I've done this for a living since nineteen eighty two. I guess I should remember some some buddy. Some caller says Markelle live the blow, you know. What is the, you know? Capital of chili and I don't know that it San Diego. What what am I gonna do? I couldn't Google it run down the street the library during a commercial break. Wow. Libraries, remember those? So the internet has absolutely made us smarter. But it has also made us profoundly stupid and gullible. And I guess it's because it used to be the library got a book. Chances are the book was filled with cockamamie BS. But if I take you to ten websites at random. Half of them could be cockamamie BS all of them could be depending on the luck of the draw. Some guy is under in his basement can have the same Thawra Tatum footprint on the on the internet as a professor an expert or in anybody. So that's what makes it all the more important to be really cautious really careful that one of those dangerous things you can say is I found an article.

President Trump George Washington Dennis Dennis Avi Mark Davis president Trump Tower mount Vernon Dennis Prager Vitas New York Google San Diego north jersey Thawra Tatum Blasios Ling Markelle professor one thirty nine minutes