29 Burst results for "Crick"
Not Another D&D Podcast
"crick" Discussed on Not Another D&D Podcast
"Big bear, and I'm just like, look, I fucking hate this guy, but maybe show him a little bit of clemency for the sake of kuta. Go ahead and give me a persuasion check. Okay. And you could do it with advantage, big bev likes coot or two. 25. As you whisper that to big bev, you see he still got his eyes on Glenn, but nods, and he goes, you're lucky, you're real lucky. The only reason I'm not killing you is 'cause I like your daddy. Wow, looks like your father really continues to be a hero. Yeah, yeah. He's a real good guy, and you better hope that he lives a nice, long laugh, because the day he dies, I'm coming for you. So I'd get a head start and get the fuck out of the crick. Yeah. And big bev scoops him with a wing and tosses him out into the Woods about a dozen feet, Glenn crashes into a tree, then hits the ground and scrambles to his feet kind of looks around not sure where to go. He's angry crick elves in all directions with bows drawn, not a friend in the world. But he kind of looks over to you, Callie, the person that he's kind of always been able to manipulate. Callie, please tell them. Tell them there'll be an unreasonable. I think I finally see him thought he really is, which is just pretty poison. So I think I just chill my passions and avert my gaze. Callie, you look away, and you are the only person not looking at Glenn as just a bunch of angry rangers, stare him down, keep their bows drawn and Callie, you feel this coldness in your heart. As your attachment as you're infatuation with this person, finally, finally dies, you finally let it go. And as Glenn sees that he's not winning you over and all of the elves are standing ready to attack. You see big bev lurches forward, smoke coming out of his nostrils and Glenn kind of just backpedals and takes off into the Woods.
America First with Sebastian Gorka Podcast
Senator J.D. Vance Gives Us the Latest Out of Ohio
"Vance senator Vance, welcome back to Merck first. Thank you, Seth, how are you? Good, good, good, good. I wanted to play the clip we've been playing a view drawing that little stick through the crick and then seeing all those pollutants well up. Can you tell us what the latest is from east Palestine and how our Ohio, ohioans doing without the meaningful assistance from this administration. Yeah, well, a couple of big updates. So first of all, they still have not fully cleaned up the contaminated site. So you think about what's causing those chemicals in the water. It's the leaching from the soil, the soil is still contaminated, and they haven't cleaned it up. This is the second thing, of course, the Biden administration continues to largely be MIA, especially the Department of Transportation. The EPA has spent a little bit more time in east palestin. I've actually been happy about that, but everybody else seems to be ignoring these guys. Why is the president not going? If president Trump can take the time, why does Biden not go? Well, by the way, president Trump coming, I think, actually really forced the Biden administration to do more than they were doing at the time. So any action we've seen from them, we've seen in the last week since that visit from president Trump. Look, I think Biden thinks these people aren't his voters. He doesn't care about them. It's really that simple. I think the Democrats see American politics in a friend versus enemy kind of way. They didn't vote for him, so he's not going to pay him any attention. It's disgusting, but that's the way that he sees it.
Not Another D&D Podcast
"crick" Discussed on Not Another D&D Podcast
"About the puppet show. Why are there more ways than one? I do a little ventriloquism for Calder. Hey, Calder. It's me. Get away from me. Devil. Without your guys monotones, you guys no longer have the power to just rest essentially when you level up. So you guys are beaten up and exhausted. But you guys have gotten some short rests in. So you do have some abilities and stuff, but I think Callie's out of spells and calders probably pretty low. But you guys see in a frenzy, bumpy turns into a horse with a bowl cut and starts looking around. Anybody need a ride? We need to move. I probably can run on my own, but you should probably carry Calder. There's really shocked from the puppet show. Right on yeah, he looks, he looks spooked. He's really big. Maybe me as well. I'm still really. All right, yeah, I could probably get both of you. You see, Calder and Callie jump on the puppy's back. There's a loud crack. Oh. Put me down. You see, it falls over on his side. But then gets up. He begins rushing you guys through the Woods. Pretty slow, Saul, you have to keep turning back to wait for the single horse carrying way too much weight. I'm running in place a little bit. Yeah. You good? I'm like at the back and I'm trying to use my feet to help move us. That is that actually helping a lot. I appreciate you. Calder's sitting side saddle. That's worse. Why? Yeah, crunches the ribs on one side. But you guys, this is how I learned. You guys rushed through Woods. I'm not going to follow up. I can't believe I didn't notice this when you run. It's so weird. You guys rushed through the Woods. You pass crick rangers bearing torches, searching for their elders, combing through the forest. And before long, you guys reach the edge of the cricket itself and see the timeout tree comes into view. This old leafless willow tree. This was Glenn's prison for a time when you guys saw him last, and you see that it has been abandoned by the guards who were on duty there,
Not Another D&D Podcast
"crick" Discussed on Not Another D&D Podcast
"The winter. You did say that. At a serpent at a serpent. The serpent slithers along the ground. Good serpent. Called her can't stop smiling. Yeah, The Serpent, The Serpent like hovers a little bit, it's not just a slithering on the ground. Just kind of hovers through the Woods. Quickly going through the trees. Fuck it, I crack a beer. It's almost bad. Don't tell me. I was gonna take it down. Drew a prescribe them. I was feeling drowsy. Sweet. So you guys reach the edge of town and begin passing more of these like scouting parties and crick elf rangers who are preparing to defend the crick, and you guys kind of follow you guys have that map that L's or gave you. So you kind of can kind of map out where the high kings fort is in relation to where you guys are right now. So you guys have to hike for a while. You have to hike for like ten miles. And then as you guys arrive near where you know the fort to be on the other side, go ahead and give me perception or insight checks. Oh my God. This is dice. 23. 7. Okay. 8. Great. You guys arrive and see the same natural overgrowth that you see throughout most of the crick. But you also see these old stone walls and an old stone keep. They're massive. But they look like ruins or like they haven't been fully built yet. And Calder, I'll say with that kind of insight check, you're kind of reminded of the hollowed out reflection of the coliseum that you guys saw when you escaped lavery's layer to the crick. And I think maybe you realize that the crick reflects the natural landscape of the living wood, but only very magical or powerful humanoid made stuff is reflected, so the fact that this dude's fortress is showing
Not Another D&D Podcast
"crick" Discussed on Not Another D&D Podcast
"Aren't the blues super strong? Would we be able to attack them at all? So actually that's I had this thought and it turns out yeah, they're like really, really, really powerful. Okay. They've got four high printers, which are like adult blue dragons and an ancient dragon. And dragon out. Yeah. They did chase out shiba blight. Sorry. That's fine. Are you okay, man? I'm good. And they've pushed to see the deep elves. There's a lot of memories there, but not all good ones. So yeah, I agree with you on that at that point that we're just, we're just playing Glenn's game. It's like a false. He's saying, here's two paths, and he's shielding us from the fact that no, of course there's not too path. So there's only two paths forward for you. Yeah. Right. Should we talk to me mop about this and see if maybe we could leave some sort of strike team and trying to at least reduce their army somewhat? The thing is, I don't feel good about taking any crick out away, right? Because we don't know if Glenn's going to go after them. But Glenn's plan seems to require them to be decimated by the blue elves, right? So presumably there's a fair battle between the two of them. And there are still crick elves here who would rally to cleanse cause. Yeah, I think we should fucking find out who that is though. Could we like create some sort of decoy where we plant like a false ranger that leads them in a different way? I think we just do like decoy stuff and try and kill the ancient blue dragon. If this full print is and the king gets killed, they're gonna be fighting each other for power. Do you see what I'm saying? Yeah, yeah. That's what I'm thinking, and I don't know enough about. I mean, can I do a history check to know if it sounded like these princes were doing little coups against each other, right? They don't go ahead and yeah,
Telecom Reseller
"crick" Discussed on Telecom Reseller
"This is the green and I'm the publisher of telecom reseller, and today I have Scott crick Burke, who is the head of strategic alliances at detent, Scott, thank you for joining me today. Yeah, absolutely. Thanks for having me. Well, this is exciting podcast. We're going to be talking to you today about some developments with your company and Microsoft Teams, a big talk with cura TR, but the first Scott could you tell us a little bit about detail. Absolutely. So D ten is a highly innovative technology hardware manufacturer for the UCC space, specifically video conferencing devices and we kind of came out in 2017 alongside zoom to release the first all in one collaboration device for their zoom rooms, ecosystem. So before that, it was a lot of component based rooms where your microphone, your camera, your PC, everything was separate, tons of cables, and failure points all over the room. And what we did was package all of that into a very elegant touchscreen device that you could hang on the wall or put on a cart, and all of your components, peripherals, everything was kind of built into one single device that plugged into the wall connected to Wi-Fi. So not only was it a beautiful design and very innovative for the time, but it also really kind of drove the all in one touch, shift in the industry and just gave customers a new option on how to meet how to clean up their room and how to really advance and enhance their conferencing and their tech stack. So we got started in 2017 with zoom. We've released multiple models that since then, we have a 55 inch touchscreen 75 inch during the pandemic. We created a 27 inch all in one for your desktop. So if you weren't in the office, you still had weight boarding and all of your video collaboration tools kind of condensed and right there on your desk. And we've just continued to innovate
Not Another D&D Podcast
"crick" Discussed on Not Another D&D Podcast
"Cool song. Patrick, Nate H, Michael, the esri pop idol. Morgan M appealing sticker. Stephen E happy bladed birthday Calvin, sorry the Vancouver nad pod live show got pushed 8 months. We're sorry too, but that's just how it is sometimes. Happy birthday, Calvin. Sydney and Andrew L John Adams, yes, like the president. Wow, what an honor. Meg, the mail carrier of Mia. James F, cap and cappy, M4 L, wayfarer, currently in a trademark dispute with mothership over the patent on the SS storm Bjorn, good luck, Andrew B cope fresh, bar Poe good barrel, the barbarian and brewer emeritus of water deep. Welsh lander, Garrett G AKA one big curd. Eric M mister D dang a daisy, mister silly head, monster captain Renee S, hop, the dancing rabbit, hope stagger the only dagger of hope. Olivia, the enchanting Bard, who will totally be making money and a grand novel off of the duck team tales with an on the go all the stop show. Blue slayed the artificer. Michaela R, Riley S, sir sig 93. FICO, angry, wheat. The game itself just trying to find himself damn. Toe knee G corbo calamitous cum shot hashtag CCC forever, sorry, Jake. All right, all right, all right. Josh, H Jack, the Jack jinxing rogue on the run with behoove me as balls. Come back here with my balls. A horse killed by hard won. Mango empanadas. Timid are. Yes, I'm the twin brother of demidov, no, I'm not proud of it. Rented mules. Drug dog. The burn in ater. Clementine tea, Caleb L Simone tried whisky and liked it Morgan, hell yeah. Welcome aboard the good ship whisky. This message has been brought to you by fairies in support of hashtag CCC, O God their number keeps growing, what are we going to do? Hey, the arcane trickster goose, cantrip Dumbledore, the bear onesie wearing barbarian with a bad back, papa wookie, MJ, the BFG drinking tea by the sea, little ferret pal, Samantha K up big squid. Cronus maximus. Gino T squid minty, Aiden F crichton mcinnes. Fey father, father of the fame. Mama bell. Miko, annoyed elf. And Sheldon the mushroom turtle. Thank you all. So, so much for your continued patronage. We love you all. You honor us. If you would like to join this illustrious number, go to Patreon dot com slash nad pod. That is all from us for this week. We will see you again soon. Bye bye. That was a hit gun podcast.
Not Another D&D Podcast
"crick" Discussed on Not Another D&D Podcast
"Brian G joy T, Nara. Kay. Jake L Nick W brave the badger. Fostered the ghostly duck says happy Halloween. Aaron, the asshole ranger, big bad, beardo the mad. Eric McGee, giant monsters, on the horizon. Glad rozelle, the white rose of glider on. Christian a, J dragonborn. Joe Rowe, the inappropriate Liam Dee, the sendrayan. Ben a Phil donus, John. The third, Dave H, Vivian, koala bear, Catherine S, David Kay. Christian S, Dustin S, Connor F, Hawkeye, pierce. Book far's assistant is EF, who is planning a fey wild style engagement party, while that sounds like a night to remember, have fun. The time walker, marky Mark, the marvelous mining engineer. Cat C, Kelsey J pork chop. Misa of house in zhun za. Ariel, the occasional mermaid. Selena N AKA raptor. Be perky always. Pat L, a chute the a Warren H Ryan S, the bone duster. Any M, the crochet crafting queen. The charming, fluff. Robert crisps. Telly kitty creations, fan illustrator, insert request here. Oh, wow, that was a juicy episode. I'd have to either go with Callie having a meet and greet with The Serpent or of course Saul hanging out with his best buddy Emmett. Up to you. Carly a, Addy Kay. AP cleric, Lori P just a raccoon that has a gun. Normal. I love it. Conor S Christopher J pebble pot. To the do riders, my first D&D party may all our adventures be wondrous, thank you for being my Friends. Oh, so sweet. So Theo, Leviathan, bio quirk 7 amber dexterous, Sullivan H, trob hopper, Sydney Tatum. Jack Hubert strong Caldwell conspiracy theorist, thank you, my friend, keeps spreading the word. Van der says at CH Murph,
Not Another D&D Podcast
"crick" Discussed on Not Another D&D Podcast
"Oh my God. She's like three images. There's just like, oh. You see, foster looks around, kind of happily. Foster flaps around looks excited. You see enormous bobcats, like they look like bigger than tigers, hunting dire squirrels, squirrels the size of like dogs, just fighting back and forth. I'm nearby extremely jacked cows and bulls are eating grass. Absolutely fucking that crass. Everybody routine. Go ahead and give me perception checks. Muscle milk, I guess. Ten. 17. Another three. Okay, here comes the 7. You guys look around and on the one side you guys have these rolling hills with all these animals. And on the other, you see that the landscape sharply drops off a cliff. And you see that you are quite high up here, you can look down and you see miles of beast lands from here. It looks like you're on a giant floating island. You can see white fluffy clouds off the sides that look like they just go off into like a misty abyss. And on the circular island itself, you see that the terrains and climates of the different sections change sharply. There's like no transitional area. It looks like you can be bordering one area that's jungle and then kind of just step into desert on your next ride. You see that there are several suns and moons in the sky surrounding the floating island in various
Not Another D&D Podcast
"crick" Discussed on Not Another D&D Podcast
"Venom all. Again, I was completely passed out. I did very little. Whatever you did or didn't do, I did use this curse to help a lot. Yeah, of course. I take some crick water. I'll grab some passionflower from vines on the trees or whatever make you a little soporific cocktail. And I bless and barbecue. That's great. This smells amazing. Blessed and bardic, so you have ten charges, correct? Yes. So you've got less. You've got bardic. Is everybody going to bed for the night? I trans. Okay. So there's no trends. I'm going to give Calder my scarf. Thank you. You know what? You run cold, but you might need it. It won't help at all. But it's all I can do. It's a nice gesture. Also put foster in your lap. Hey, buddy. Just to make sure that the snake doesn't attack you. Thanks. Thanks, guys. See it hovering. What did I do to you? Yeah, it's all gonna fall asleep knitting in a corner. Sweet. Yourself a new scarf. I'm not giving this back. I was actually making a bra for Callie. Callie's eyes fill with tears. You are reminded that she is still raining. There are little nander flies on the pattern. As Saul crochets, Callie goes into her trance. Yeah, you guys set up like a little campfire just outside the crick here and you guys get ready and you go to sleep in your bed rolls. Since I only have to transfer four hours though, can I kind of like keep an eye, watch him get into rem. Sure. Kind of like basically delay it, I have no clue what I would do if things go bad, but just I only have to transfer four hours. I just want to be. Oh, of course. Watching him. Hold your sleep action. You ready? You're watching Calder. Can you hang out with me till I fall asleep? Yeah, I can, actually. I take out my bird pipes. Let Adam Duritz. Hey. Yay. Love you to sleep. The last thing you hear is yes. As everything goes dark and you finally fall asleep. And I picture this being like the camera on your face, and then you tip into my lap, right? You kind of see that. Piece of paper. I treat you this. Oh my God. Oh my God. So challenged at bully want to have fun. You really see beyond the line. Your drawing brings it to life. Calder, you fall asleep, everything goes dark, and once again, it's like you blink and you open your eyes and you are on this frozen plane. You see in this force cage across from you is ultras. Hello little mouth. You see he starts banging on it. And you hear a sound like he's banging on a door and you see cracks in the force field. Let's me in, easy, doesn't I'm trying not to go to sleep. Trying to go to bed. Let's me
Not Another D&D Podcast
"crick" Discussed on Not Another D&D Podcast
"All right, and Callie, you're gonna stick around here? Yeah, but I do need a quick water. You want me to grab you anything in town, quick water, anything else? Souvenir. Pizza. Pizza. Pizza. What is that? I don't know. I said a nonsense word. That's so funny. You gotta spell? I'm gonna use that in town and people are gonna look at me like I'm insane. So Saul bumpy and Calder walk off towards the town. You guys enter the quick town square fight a huge bonfire in the center. You hear the bubbling sounds of the crick flowing nearby. You see young children running around getting way too close to the fire and playing with it. Touch the fire. Touch the fire. Are there any chaperones? You see, no. You see a ten year old watching an 8 year old. That's me. Wait a minute. These kids look happy and like not downtrodden by society. What's going on here? Yeah, you see young kids are running chasing each other around fighting with sticks, just being wild. That one has a really big stick. Yeah, and it's on fire. Hey, careful with that one Petrie. How's everyone in Petrie? You see all of the stumps are connected by ropes and rope ladders and stuff so they can enter from above. You see the ropes have magic lanterns on them that turn on as the sun begins to go down. You see the biggest tree of all is this massive hollowed out one that goes up so high it bursts through the Canopy, the trunk is so wide that it effectively acts as a massive building. You see bumpy points that out as being the grandma tree. Calder
Not Another D&D Podcast
"crick" Discussed on Not Another D&D Podcast
"Friends of friends that like your friends with Oprah outright will have spoken to ober. I would say oberon is a distant acquaintance, if anything. I mean, it's been decades. Okay. But distance, I mean, to say to a distant acquaintance, hey, I found your child. I'd want to know. Come get your snake. Yeah, come get your snake. After the meet and greet. Which we are going to charge for. That's a great idea. We got to buy potions, come on. Well, I can get you to the beast lands, get you an audience with oberon. Really? Oh, yeah. We do stuff like that. Hell, I helped move this whole fucking place to a different plane. Holy shit. You're crazy. It's all vowels. Yeah, okay. You don't need jail? It's all right. I just pledged myself to Queen hopper's apartment. I'm feeling like this is it better. You have to stop treating kind of a fuckboy. You played yourself to every fucking woman you meet. Queen upper sport will understand. How are you vowing to lower than me? I pledge myself. All right, well, that's nice. Nice to meet you too. But yeah, if I do a certain ritual, it'll take me a little while to get the components and everything, but I should be able to take you tomorrow morning. That's great before we go. We, you know, there's some news from the picture a little tidbit that you might want to know about. All right. There's trouble brewing. Deeply in this. Very, very nice. Something that has been sewing the seeds of war. It's intentionally amiss. It's intentionally amiss. You see? Is someone he calls himself Glenn, and he's, but he's actually a crick elf that's a strange himself from this beautiful place, and he's been trying to get everyone angry at the crick elves so that they would invade. Yeah, bumpy mentioned that there were some dissenters back in the day. I don't know if you've kept tabs on any of them, but it seems like one of those rotten seeds is grown into a whole grove of shit stuff. Shit push. Guys go ahead and give me insight checks. Shout out to the three little turds. Okay. Dirt he 20, which is appropriate for the crick. I got a ten. Callie, I'll say she kind of tries to keep it to herself, but she looks like she knows the score a little bit. You know, at the very least because she sent bumpy and Petrie and junior out to scout to find out about the fake void elf attacks. She knew they were in danger and that they may have to defend themselves at the time may come when war came to the crick. But you also get the sense that she might know who Glenn is. But she kind of just nods. I think alien in and I say, he smells like sandalwood. If that jog is any memories. I think I have an idea who he might be. Is there anything we can do to help? I mean, it's nice of you to take us to the beast lands, but I don't think we can leave the crick, knowing that it's in danger. Well, if what Patreon junior told me is true, I imagine whatever happens will take a minute for it to come together. I think we've got a few days at least. All right, okay. Okay. So we can go drop off the kid, and then head back here. All right, why don't I stay here with this little guy? We can get the ritual started. We can make sure that this guy doesn't go off causing trouble. Bumpy if you want to take them into the crick, you can do that, or you could stay here with me. See, bumpy goes, do you guys have a preference? Do you guys think Pinocchio junior needs another buddy? What do you think? I kind of promised him that I wouldn't leave him again. So I think I've got to stay with him. I take a drink in the crick. All right. Why don't we a couple of us go in, Callie can stay here with me, mom. And we'll bring you back some food. Yeah, it seems like the surfing is safe here. I'm kind of interested in seeing where I used to live. That's a weird thing to say, but I imagine I had a house here or at least a place where I slept. I would love to kind of revisit the steps of myself. Oh, you were, you were more just passing through the living wood. And I came to you, so you weren't in the crick. Oh, specifically. So this will be a first for you. Oh, great. There are creek bully works here, though. Oh, okay. Yeah, I would love to, you know, you know what? Oh, do they ever do a little chorus? Yeah, time to time, I suppose. And I got a taste for a crick water these days, so I wouldn't mind wetting the nostrils. All right. Yeah, we're all getting in touch with our wild side a little bit. I'm gonna go meet these quick bully logs.
Not Another D&D Podcast
"crick" Discussed on Not Another D&D Podcast
"Going at it. Can I speak with animals on the fucking chipper monks? Yeah. Hey there. Wait, are they fucking your fucking killing you? They're fucking killing each other. Oh, okay. Hey, I was kind of in a fight there. Yeah, who's winning? I added 'cause I can tell. I used I used a magic spell to win. Wow. I know fireball. Hey, you guys fireball. Good for you. Cute little fireball. All right. It burns. Yeah, I scoop it. All right. Wow, we're collecting animals. That's Superman comes along with you. Leaves the roasted corpse of another chipper mom podcast. Fireball on. Or you can call you Pete three. E 3 p.m. is very good. So yeah, you guys eventually, as you start to get close to the, you begin to hear stuff in the distance and you think you're starting to get close to the actual town. And eventually you guys start to see scouts overhead like crick elf dragon riders on young black dragons and dragon elves flying overhead. You see bumpy turns from a horse back in his crick elf self and starts waving. Hey, we need some help down here. And you see, as these guys swoop down to approach, The Serpent goes to a launch update. I'm wishing I'm with no, no, you're safe. You're safe. I promise I promise I'm gonna make it right. You are safe. You are absolutely safe. No one will get to you. They will have to come through me first. Yeah. Go ahead and give me another spell casting check. You can do it with advantage because you got now you got the whole team helping you out. Yeah, freezing cold hands on this thing. Oh, natural. I didn't even need the advantages. Okay, this thing calms down. It goes to like launch up and then it sort of recoils and goes down towards the ground. The Serpent is like snarling. Essentially wants to protect you guys and you see the dragon riders go. I protect you. The hell are you bringing here bumpy? We're just as friends. No, I'm not talking about you guys. Welcome to the creek nasta meet all of you. Thank you. Nice to meet you. You might have met me before. It's unclear. It's all buffo. Now, James doesn't mean anything to me. But nice to meet you and bumpy goes, okay, the serpent is a little bit dangerous. It might be better if you got meemaw and you brought her out here. Yeah. And we figure it out out here instead of in the town square. Just nobody get in front of the duck beam. The duck beam is crucial. Duck beam. All right. I don't know if The Serpent looks kinda cool. Can I meet your snake? It could fossilize you almost instantly. Fast last me, all right, well I don't want to be fossilized. All right, we'll go get me ma. You see they fly off, there are some creek elves on the outskirts here. You see they begin to poke their heads out of their stumps. Hey bumpy, what you got there? Stay away from The Serpent. Can I meet your snake? Absolutely not. Not everyone here is dangerous. Is that like a bonds and noble that we could just do a meet and greet at? Because I think everyone's going to want to meet this thing. Yeah, I could start a main grape for the snake if you want. Nobody's doing them angry with a snake. It's going to be in heat because it's going to be breathing fire on you. Okay, but actually though I do think that they deserve a meet and greet. All right. Starts walking towards The Serpent surfing. No, no, no, a later time, at least. All right, well, you got to specify that. Just go and prepare your house because you're going to have guests over. All right. Yeah. We're going to do it. I gotta clean up. Yeah, exactly. Sorry, hey, what's your name? Petrie. That's a different beach. I need you. Okay. Finally, you guys see a crick elf woman ride in on a black dragone. She wears a green cloak. She's got white hair with a streak of red. She's got freckles and kind of crow's feet at the edge of her eyes, but otherwise looks ageless. You see the dragon L plans, and she dismounts. Welcome to the creek travelers, my name is jolene sobin, and I'm the
Not Another D&D Podcast
"crick" Discussed on Not Another D&D Podcast
"I say, I don't know what happened. I guess just keep doing whatever you're doing foster and Callie because if that's the thing that did that to that dragon, we need to avoid that happening again at all cost. And we didn't see any evidence of Glenn, did we? So I'll say, with and above 20 check, you walk around and I'll say Callie can kind of point out where she saw the arrows coming from. You go through some of the tunnels and you do find one that smells of sandalwood as you walk in. And you find a note posted on the side of it. It looks like it was a stabbed into the wall with an arrow. This is what to me. And this one just says war is coming to the crick. I win. Well, that would be it must have wrote that in a rush. Okay. So I saw then or rather I heard him and this is all by his design. He's a crick elf. Yes, I don't know what his original name was, but he's a quick elf, and he got frustrated with the fact that the crick wasn't standing up for itself and was getting such a bad lot in this forest and his whole plan was to stop war, like basically have the crick invaded and then defend it and best everyone else. Shit. It's kind of working. Yeah, we gotta warn the crick. It was, it was effective. Yeah. But that arena was an ugly scene. But he couldn't make a weapon of this one. Then I point to the silver serpent. But there are two more. I think. I only have one egg. I think that there might be two other eggs, like elsewhere. Okay, yeah. Entirely. Maybe back in the feywild. Maybe entirely undiscovered. But if he's just trying to get the crick invaded so that he can attack everyone. It kind of doesn't matter either way if he has a weapon or not. War is coming. Yeah. Is there anyone we need to tell? Yeah, we gotta tell mimo. We gotta tell everybody. All right, yeah, let's get going. We're in the crick right now, aren't we? Can we get there from here? Yeah, we can get there. Oh, this is the crick. Oh yeah, check it out. You see you up there? They're pretty far off. They were probably kind of scared by the fight. That's called a nanner fly. Why do you have so many teeth? Yeah, no, they're pretty vicious. You know, you've fallen asleep outside. They'll try to eat you, it's usually not fatal, but they usually
Not Another D&D Podcast
"crick" Discussed on Not Another D&D Podcast
"To the crick. Though that's the crick? Oh, all right, full speed ahead. You're the one running. You see, Bobby doubles down, just running as fast as he can. Just full sprint full gallop rushes towards the light and narrowly is able to jump in before it closes. The three of you crash into the dirt as you land in the open air. I mean, you guys find yourself in a strange reflection of the arena. The top of the volcano is broken off. This looks more like ruins with grass and overgrowth everywhere. And it's eerily quiet. This is the crick, huh? Yeah. Was there a crick of somewhere that? You said this is the white Callie went. That's the way I saw her come. Go ahead and give me perception checks. Damn, I just can't stop rolling 5s. Jeez. I feel the same way, but times four and at 20. Wow. That's awesome for you, man. It's so sick. Saw that's awesome, dude. Do you want to see my dice? Yeah. Here you go. Salt. You see camouflage amongst all of this overgrowth is the fossilized body. Of an adult dragon covered in vines and leaves. This massive beast just devoid of flesh, just perfectly maintained skeleton here in the ruins. And nearby in the tall grass, you see that foster is locking eyes with a 8 foot long silver serpent that seems to be in a trance. And next to them, calliope is lying, unconscious, but breathing. Callie, Callie. Yeah, we rush over, sweet, you rush. At the ready. Double potions ready to jam both in our mouths. Icy cold. You feed Cali a potion and Callie you wake up. You see your Friends above you, you're no longer on top of The Serpent, you're kind of resting up against it. It seems like, yeah, The Serpent is locked as with foster and it seems like foster is kind of just keeping it calm, making sure it doesn't run away while you're knocked out, and they're both just kind of looking at each other. Is that the, is that the thing is that The Serpent? Yeah, this is what I had from the egg worst Glen. Where's venom? Is that corpse venom? Can
Not Another D&D Podcast
"crick" Discussed on Not Another D&D Podcast
"Throat out. My Queen. You see, prince cobalt had like a few young blue dragons that were around that were fighting with like el zor and stuff. They see cobalt dead. They fucking retreat. They just disengage. Queen umber sport goes to take off, but her wings look injured. And she just goes, you have to go. Leave me. Is there, can we do anything? Salt. We have healing potions. Can I give her a flying potion? Absolutely, yeah. Wow. So I was like patting down his pockets. You see just like, you see like so many tubes of GO-GURT just falling out. It's like, it's gotta be here somewhere. Oh, here it is. Hands are flying potion. You hand her a flying potion and she looks at you kind of quizzically. A dragon taking a flying potion seems strange, but that'll work. Launches forward, just eats the whole fucking thing. You see, she begins floating in the air despite having badly damaged wings at the moment. You see el zor yells down to you guys. Watch her and we'll get her out. Yeah, are you coming with us? We have to find Callie. Yeah, she went down that tube. Okay, good luck. We'll catch up with you later. Yeah. I mean, he's pledged to your mom now, so we're probably gonna see each other again. Great work. We're siblings now. Amazing. I don't know you could be siblings. Yeah. Okay, you see an igneous take off with Queen umber sport up towards the caldara. You see bumpy is there bumpy goes all right, let's get to that too. Yes, sir. Hi oh bumpy. Bumpy begins wild shaping, turns himself into a horse with a bowl cut and scoops the two of you up. As you rush towards the magma tube, where you saw Kali running. Before we go, what happened to the muzzle? Oh, you can grab it if you want. It's like it shattered. It's fucked up from being in that fight, but yeah, I just don't think we should leave evidence like this around. Yeah, you pull it off the corpse of the green dragon before you hop on bumpy. And you take it with you. Great. You guys see as you're going through this tube in the deep distance, you can see light. But strangely, it's getting smaller as you get closer to it. You also notice vines along the wall that are beginning to pull away and retract towards the light and bumpy shouts up to you guys. There's a gate ahead, but it's closing. A quick, get through the vent. Gateway gate to where.
Not Another D&D Podcast
"crick" Discussed on Not Another D&D Podcast
"The campaign. This is not another D&D podcast. Welcome back to behoove everybody. I'm your dungeon master Brian Murphy joined by Jake hurwitz. Feeling a bit shit in the dragon pit. I'm getting my ass kicked. Emily axford. Newly emergent as a serpent user. You lie to me. So excited that I said quiet feet. I thought you said you lie at me, I'm gonna say. Petrol. I'm gonna say that whenever you do a deception check. We're like, you lie a pee, Petri gore. And then of course, Caldwell Tanner. Stunning striker who looks great in a tie, sir, soul, buffo. What? You haven't gotten a chance to see him in a tie yet. He looks really good. It doesn't completely rhyme. Yeah. I would argue it was a rhyme at all, but let's say a stretch and a slant. Right. I mean, but that's why how I tie a tie is I stretch it out and I do a little slant. He's doing the gymnastics to make it work. He made it work. It all checks out. He pulled up. Gymnastics. And with that, let's go ahead and do a little recap. So last time, you snuck into the dragon summit at labyrinth's old lair. There, Callie used a clairvoyance potion to spy and learn that queen umber sport and Elsa have been kidnapped by the greens. You snuck into the basement to free them, then donned the masks of their captors as you let them out into the coliseum pit in false bindings. Then, Glenn fear glade win, took center stage and addressed the arena, saying that he had a powerful new weapon that he could use to kill the king. Glenn unveiled a young green dragon in a strange mask that seemed to harness the power of the wild. Suddenly though, you received a surge of power from beatrix, who lit up the magic lanterns around the arena and set the whole place on fire. During the chaos, umber spores Saul and Calder, leaped into action against the green dragon while Cali chased Glenn down a magma tube. Goodbye a pea. There you go. I only do bad rhymes for myself. Everything else is fucking gold. Is that your mouth? All uphill from the run. He started low at the beginning of the episode. You can only go up. Callie emerged on the other side in a strange Demi plane that appeared as a reflection of the arena you were just in. There, she saw The Serpent weakened by an arcane collar and snatched out of the air by venom, the lead dragon of Glen's order. Meanwhile, Saul and Calder were ambushed by the high prince cobalt as they battled the adult blue dragon alongside Queen umber spore, Glenn revealed to Cali his true motives war and chaos in the living wood. Glenn is a crick elf who became disenchanted after they hid their home away instead of conquering their enemies. Glenn believes his machinations will eventually be pinned on the crick and he can lead them to war to finally prove their greatness. Callie was sympathetic and asked if she could just see The Serpent. As she got close though, she was able to outmaneuver Glenn and venom slashing the collar from The Serpent's neck and freeing it as Cali and foster mounted The Serpent Glenn shouted from the depths and venom pounced into action and that's where we are now. But. It's been a minute. I can't be there now. Look in your eye. Because we are back in initiative, baby. So Callie and Glenn have just gone. So she has used a bonus action to give a bardic to The Serpent. She used her action to cut the collar from around its neck. It is now free and facing down venom. So both of you guys are kind of floating there. Glenn has already acted. He was too slow to hit Callie. The arrows kind of just plunked into the ground as you used your maneuvering flourish to move yourself 15 feet to the side. So free from this arcane restraint, The Serpent is free to act, facing down venom. And it is beginning to charge its breath weapon as venom does the same, jumping up and rising to meet The Serpent in the air. They are going to act on the same initiative, which is right now. Wow. Callie is there. I mean, you don't really have a turn, but you can try to do something to bond with The Serpent. It seems like you already have. This serpent already sees you as an ally, but not as like, you know, it's master or anything. And I'm not trying to be that. I think that truthfully in this moment, I am just so happy that this little creature is free, and so I think I'm just clinging to its neck and it will do as it will do. You see, foster, right next to you, is all puffed up red eyes. The Serpent's eyes are glowing red. You see that there is a projectile of poison breath shooting from venom's mouth. That meets this dimension altering breath of The Serpent, sort of like a circle of storm of lightning and vines, it looks like a tornado shooting from The Serpent's mouth that sort of shifts reality around it. You see shocks of lightning, thorns and vines, meet venoms, poison breath. And there is just an explosion that envelops everyone in the arena that envelops The Serpent, envelops the dragon, Cali, I'm gonna need you to do a con saving throw and venom will do the same as you are both enveloped by your enemies breath. Maybe bad. I got a 7. Callie, you take 58 damage? It is the most pain you've ever felt.
The Charlie Kirk Show
Dr. Stephen Meyer: The Foundation of Life Is Not a Simple Cell
"How would the mutation and natural selection mechanism ever build a complex new forms of animal life. We know now post Watson and crick and the molecular biological revolution and the human genome project and many other things that at the foundation of life, we have not a simple cell as Darwin thought in his time, but instead the cell is understood to be chock full of complex information and a whole complex information storage, processing, transmission and processing system. So we've got high-tech digital computing technology inside even the simplest living organisms in their cells. And to build a new organism, you have to modify that genetic information that code. And we know from our own experience in the computer world that if you start randomly changing sections of functional code, you're going to degrade that information long before you ever build a new functioning set block of software or in operating system that random changes to specified information invariably degrade that information long before you ever generate anything new or functional or useful. And that same thing appears to apply in the biological case so that the mechanism that the darwinism and neo darwinists have long relied on, namely national selection acting on these random changes in the genetic text called mutations is very unlikely to produce anything functional or new, even taking into account the billions of years of life's history on earth. So
The Eric Metaxas Show
Dr. Stephen Meyer on the Concept of 'Directed Panspermia'
"Well, when he talked about panspermia directed, it's so ridiculous. Talk a little bit about that. Because you're asking somebody, hey, how did life form? How did life come into being? And this super genius scientist says, well, we don't know, and but then he says, but we think maybe it came from someplace else. And just ended up here. And you think, that's not the question. The question is, how did this has been formulated as a somewhat serious proposal by several scientists? Crick did write about it in a technical paper. I think it was 73, and then in his little book, life itself. It was published in a journal called Icarus. That's exactly right. Very aptly named. And then in 81, he wrote this little book life itself where he floated this idea that he said, getting all the conditions just right on Planet Earth are so improbable that it's almost equivalent to something like a miracle. And so then he said, so maybe it didn't happen here. And maybe it happened somewhere else that life arose in some other prebiotic soup on some other planet where the conditions were more favorable than it evolved to a sophisticated intelligent form of life that then seeded life to Planet Earth. He later kind of regretted that. And pulled back a little bit and said, I'm not because it was ridiculed a bit and he said, I'm not going to speculate on the origin of life problem
The Eric Metaxas Show
Eric Shares His 'Socrates in the City' Conversation With Stephen Meyer
"Hey folks, you're listening to special edition of the airport taxes show. We are airing my recent socks in the city conversation with doctor Stephen Meyer. He then proceeded to explain that he was really moved to a point of thinking deeply about religious faith because whereas the evidence was pointing unequivocally in one direction, he didn't want it to be so. And then he began to explain that he began to think about, well, what is it about me that doesn't want this to be so? I've always prided myself on my objectivity. It was very compelling story in the very next panel. There was a similar intellectual conversion announced by a leading origin of life researcher who worked on this problem abiogenesis, named dean kenyon, and Kenyan announced on the panel. He also surprised people by sitting on the side with atheists and explained he argued that the discovery of the information bearing properties of DNA. Everything that crick had anticipated. Suggests that what he called the natural theological question should now be reopened by the philosophers. In other words, we may as scientists be looking at evidence for the existence of God in the inner workings of the cell. And so I'm 27 years old. I'm kind of blown away at this. It was clear to me that the Thea seemed to have the intellectual initiative in the discussion. That the people defending chemical evolutionary theory had nothing to offer except promissory notes that maybe we'll figure it out down the road. So I got really seized with this. I was working with doing digital signal processing of seismic data, which was an early form of information technology. And the thought that the discovery of information inside cells was the Holy Grail of the origin of life problem, just absolutely seized me. I got really fascinated with that. I met another scientist who was on the panel that day named Charles thaxton, who had written a recent book called the mystery of life's origin. He happened to be living in Dallas. I started having long conversations with him after work. A year later, I was off to grad school and realized I want to work on this origin of life
Mike Gallagher Podcast
Joe Biden: The Story That Never Happened in Southern Delaware
"Biden worries about over you and me. Ordinary Americans who have to fend for ourselves. Check this out. And I know it's controversial, but I got it done once. Ban assault weapons and high capacity magazines. I was getting criticized when I first passed this law when I was a senator. And guess what? I was down in southern Delaware, do a lot of hunting and fishing down there. And I was walking up one of the crick beds. And the guy standing, so you want to take my gun, it's not going to take your gun. So when you're telling me I can't have more of the next number of bullets in my gun. And I said, what do you think the deer you're hunter, where Kevlar vest? What the hell you need? 20 bullets for. You must be a hell of a terrible shot. I'm serious. Think about it. Think about the mass shootings. Yeah, hey Alec, I'll take things that never happened to Joe Biden for 20, please. Because that never happened. He didn't have a conversation with some guy in the creek bed while he's off hunting and the guy on the creek bed said you're trying to take away my guns. Why are you limiting how many rounds I should have? You know, corn
The Eric Metaxas Show
No One Knows How Life Came Into Being From Non-Life
"A creepy dishonesty. That the scientific establishment now, of course, this is by no means all scientists. But a number of dedicated materialists or atheists are so afraid of looking at the evidence that they will come up with any crazy answer just to shut you up. So this idea who was it? I think it was Francis crick. I mean, this is one of the discoverers of DNA, okay? So in 1972, that's what did it. When he discovered DNA he said, wow, I just blew my own theories out of that no, but that's actually true. That's actually true that DNA is so complicated that you suddenly realize there's no way life can just, because of DNA coding thanks to Francis crick and Watson, it's so unbelievably complicated that science effectively has zero answers, which today they have no answers, right? But even in 1972, they knew they had no answers. So they asked him and he says, oh yeah, I think aliens brought it from some other place. And you think are you joking? This is like a junior high school student trying to blow smoke at the teacher because they didn't do the homework. And if you say aliens brought it, anybody says like, well, that's very nice, but I'm still asking you how was the life formed? Not who carried it here, not what suitcase or what spacecraft. We're asking, how did life come into being from non life? To this day, and this is why I find this stuff so funny. And James tour, by the way, I wrote this book in part because of him. Yes. No one knows. I mean no one knows how life came into being from non
The mindbodygreen Podcast
"crick" Discussed on The mindbodygreen Podcast
"Our memory. Yeah they issue of sleep is absolutely fascinating. It's first of all one of the great mysteries. Here is something that we spend almost a third of our lives for those who are lucky to but even those who claim they don't they actually do six usually six hours over the course of twenty four hour period in a position where we're vulnerable to the world right. You would think that evolution would do away with sleep yet. We all sleep down to flies across the animal kingdom. So why is it so central. And that's always been a mystery and one ideal was proposed by francis crick who was part of the dynamic duo creek and watson who won the nobel prize in the nineteen sixties for figuring out the genetic code right arguably one of the most important discoveries in biology and he but i never had the benefit of meeting him but he apparently was a really outstandingly smart person. He said well that was pretty easy. Let's move onto more difficult topics consciousness and sleep. Of course being a little facetious but it is interesting. That's what he focused most of his career on post nobel prize and on sleep. He had a really provocative paper in nineteen ninety-three that he basically argued that we sleep in order to forget and he introduced this interesting idea. Smarts forgetting and it was a provocative idea if it wasn't published by him it probably would have gone no play but because it was him did and he spawned a group of really talented scientists. Who only in the last ten years have able to test this idea. Formerly and it turns out sleep probably has a lot of purposes but one of the main purposes of sleep is to trimmed down our memories and here are the metaphors thinking of memories as sort of a lawn of a grasp field of memories. Memories are stored throughout the cortex. And you need sleep to really mowed down or at least shape the lawn so you can actually better Remember certain items so it's sort of like topiary but fundamentally most of what your mind now is remembering throughout the course of your day. Most of it is extraneous and unnecessary and detrimental is cropped down while you sleep by the mechanisms. The new mechanisms of forgetting so. That's really really turned out to be interesting and it links into creativity. Which is the punchline of that paper of that chapter rather so what's an example of some of the garbage. If you will that our trash our trash recycler or we wanna call our garbage collector and visits us in her dreams needs to pick up and throw out right so obviously. There's a psychological. Maybe freudian take that. I'm going to stay away from that. Because it's beyond my understanding but on the neuroscience what we know is that our brains are very sticky. Another colloquial term for memory are as you're sitting here. You're hearing a lot of things. You're feeling a lot of things that you might not consciously register but your brain does and your brain is very good at remembering a thousand details. A million details and most of them are not really critical for your for your life now. It's i in that chapter. I talk about if people really object to well is forgetting really good. The best way to experience only prove that is. Ask someone to stay awake for three days. Few people have because it's actually Dangerous but some people have do have been forced to and the testimonials are clear. You don't have impaired memory. You have too much too little member you have impaired forgetting and so those people who are sleep deprived their brains are static with information. They can't think clearly. They even develop perceptual illusions and sometimes delusions in elucidations that is firmly established in the literature that to me is a great proof exponentially of why we need forgetting to be cognitively. Clear our mind and building off of sleep. What what role do hormones play right. So hormones play a lot of roles in both of benefits of memory and the benefits of forgetting for keeping this balance. Well equivocated and it's interesting again. I'm an i'm urologist. I'm a basic scientist. I was interested in the new science of forgetting. But i needed examples. That come from the way. I think right. The way i think is shown a chemical that is that it induces forgetting and appears to be beneficial. That would be helpful for me and in the book. I talk about Oxytocin oxytocin is a hormone that was first described so one hundred years ago. The biomedical field was obsessed with hormones. That's when adrenaline was described than testosterone. Cortisone and. oxytocin was sort of minimized. Partly in this. I think reflects bias in all fields by mainly because it was thought to be confined to the maternity wards. 'cause what oxytocin was first shown to do was to be important for delivery. It relaxes muscles the muscles for delivery and then it was shown to be important for for feeding babies and producing milk. And so whatever maybe it might have been Linked to bias is in the failed. It's a woman's hormone. It's not it's not a cortisol which we all need for fight or flight. What then emerged in the nineteen eighties and nineties is that oxytocin is important for all of our interactions not just interaction between mother and her child but any social interaction and that interaction could be both social and physical right and it turns out when that happens. We secrete oxytocin. And we create these sort of social bonding and then the question is will what happens in the brain. How is that mediated again the qualifier. Let's not oversimplify but the new science of forgetting has taught us that one of the main things that oxytocin does is it turns down the areas in our brain. That store fear memories. If you think about it it's very hard to establish a new social bonding if you really fearful and rachel and hypersensitive you have to relax you have to open up your heart that requires keeping your fear memories at bay so the question i'm asking myself is what do i do. You know. i'm a healthy. What do i do to make sure that. I'm striking that appropriate balance. Making sure that by brain is limber how. How could i be proactive. To to strike that balance with memory and while remembering and forgetting right so it's a great question and in fact. I describe myself a few times. I think in the book as a brain mechanic. That's what i am posed with people who have broken brain in my case alzheimer's aging. How do i fix it complicated. But that's the way i think so now. I'm saying that normal forgetting needs to work well as the engineer or mechanic i'd like to know how to accelerate that i'll start with something. That was most interesting to me. And i think most relevant in the ptsd chapter. I had a ptsd expert. In every chapter. I sort of have a guide who are experts in particular field and we went through some issues that might explain why to people who are exposed to the same trauma. One goes on to develop. Ptsd the other dozen now. It's clear that the person who doesn't was able to engage their emotional forgetting mechanisms. But what is what are the modulators. What are the risk factors for that and there are many but one of the most important conclusions and it links back to what we were saying about oxytocin one of the most important conclusions as not pharmaceuticals or molecules the way i think but social interventions in other words a soldier comes back from a horrible experience they are then forced to live alone socially isolated. That's a risk factor for developing. Ptsd in contrast that same person or person in the same unit comes back and his lived in a very coddling social environment full of laughter in that is a significant preventive of developing ptsd and again not to oversimplify but one of the reasons for that is that when you're engaged in social interactions love and laughter..
The Bio Report
Using Synthetic Biology to Craft One-Time, Programmable mRNA Therapeutics
"Jake. Thanks for joining us. Thanks for having me here. We're gonna talk about 'em arne strength therapeutics. And its efforts to develop the next generation of messenger. Therapies marna is a technology became front and center in the public imagination with the vaccines for covid. Nineteen might guesses though that most people don't understand the basic technology or its potential beyond vaccine's perhaps we can begin with amarna itself. What is it. And what makes it compelling as the basics for therapeutics to fantastic question in one unhappy dancer so There's something in biology that Jim watson of watson and crick People probably remember from biology class Jim watson called the central dogma and the central dogma is essentially that dna which a lot of people are no remember learning about in school dna makes messenger. Aren a messenger. Rene makes proteins proteins are really the essence of life Proteins are everything that makes up what you think of as your physical and we can make drugs out of proteins as well. We've all sorts of things like antibody drugs things like insulin are proteins that we can create synthetically and then inject them into the body Why amarna is such a breakthrough. Is that when marna really is Information molecule. so you imagine that your cells contain dna and they are the the source code of your being and then you have proteins on the other side. Which are everything that makes up your physical of physical personage. An in-between that dna needs to needs to send a message to your body to make more proteins in an order to send that message on your dna wants to continue to be in the nucleus. continue to be protected. Because you don't want to damage the source code until it sends these messages out into a into its cells
60-Second Science
Ancient Dogs Had Complex Genetic Histories
"Dogs were the first animals to be domesticated stuck with us as we changed lifestyles from hunting gathering to farming to city living. The dog is a species that is intimately linked to hyun history. Anders bergstrom a post. Doc at the francis crick institute in london. He and his colleagues studied the genomes of twenty seven. Ancient dog bones dug up around the world. They found by eleven thousand years ago. We see the dog to start to diversify united kalihi so we find evidence of at least five major lineages of dogs already at this time. Dog remains have been found in europe asia in the americas in a pattern similar to help. Humans moved mixed to a large degree. The history of dogs dog seems have been shaped by human history. So like the reflecting. How what you must moved. They would have brought her dogs with them. Ancient humans clearly found dogs to be very useful in the arctic. Evidence at sled. Dogs actually emerged very early on people. Use them for the purpose of leading perhaps as early as ten thousand years ago. A few modern breeds like the african basenji new guinea singing dog or australian dingo are similar to one of the five ancient lineages most other modern breeds derived at least in part from european dogs which came to dominate dog genomes. Back for five thousand years ago. There's a great diversity of dogs in europe but at some point there was probably a single population that expanded in basically replaced other populations in europe. So this was something that we did not predict sunday. You couldn't really see just from studying. Archaeology look the dna with all this diversity. In the past that is not represented in present-day dogs. The study is in the journal. Science where you'll find maps of dog migrations over time one odd finding about eleven thousand years ago it looks like dogs. Spread more widely than humans did does actually opposes. We don't understand. So how could the dogs spread so quickly widely. We're we're not aware of any human migrations. At this time that could have facilitated this spread of the dog but some of it spreads very quickly to two human groups all across the world perhaps because he was a very useful thing for his early human together. The groups humans were also useful to dogs prehistoric. Petco didn't exist so dogs. Probably humans did and is human started to form oath species quickly adapted to digest more grains. The number of copies of a starch digesting gene in both humans and dogs increased in the generation following the invention of agriculture. Yes oh that. That's a very striking example of convergent evolution between humans. And dogs. way it's gonna be interesting to think of the dog. As kind of a evolutionary experiment that runs alongside human history and undergoes. Same lifestyle changes that we do
The Science Show
No acknowledgement, no thanks for Rosalind Franklin who made the discovery of DNA structure possible
"It's the centenary of rosen. franklin's birth. This year she who made watson crick's revelation of the structure of dna possible. Her photograph of dna made all the difference and was featured in western. Play called photograph. fifty one with nicole. Kidman who else is franklin. But it was after dna. According to patricia farrer of clare college cambridge that her work on viruses and irony made work like this year's fast production of covid vaccine possible all that worth two nobel prices so far. Thank you think just portrait by malcolm. I'm watson i'm creek. Let us show. You are trick. We have found the seed of life sprang from. We believe we're stew of molecular goo with a period of thirty four angstrom. So just think this means to our respective genes that sakes did not be disgusting or you girls. Try that trick of watson and crick and achieved. Double helix lusting cheeky was recited by james watson and francis creek at a symposium in june nine hundred fifty three to celebrate the discovery of the double helix in nineteen sixty two. They received the nobel prize for this work. Along with morris wilkins. They've been basking in the glory of his saints but there was another crucial contribution to solving the puzzle of deny that of the dock lady of dna roslyn franklin. He's francis creek acknowledging homework on bbc radio in nineteen ninety nine. It was fairly fast. But you know we were lucky. You must remember. It was based off the x ray. Were done here in london. Started off by. Murray's wilkins and carried on by rosen in franklin and we wouldn't have got to the stage of least having a molecular model if it hadn't been for their work will the story is very bleak. She was naps. Brilliant x ray photographer and this was how the physical reality of the double helix model was first. Seen because wont watson and crick quarrel remodelers that that is they were abstract scientists. They were thera- titians so they were making the model as it were in their heads out of those bubbles and sticks that we all know so well which made the double helix model. What roslyn franklin's incredible achievement walls that she was a technically quite brilliant with this new and difficult apparatus of x ray photography and she showed this first image. Hilary rose from city university london. She's been a sociologist. of science. Since the mid seventy s and the image is referring to is the x ray picture taken by rosalind franklin niners photograph number fifty one. It displays a doc. Black spotty cross shape which confirmed for watson and creek. They hypothesise that. The structure of dna is in fact. A double helix. Hilary rose is passionate about rosine. Franklin's contribution and believed her story is one of appropriation and rasiah without her consent. These pictures were taken by the third noble prize winner. Wilkins and they were shown to watson and crick in cambridge and this is appropriation. I mean there are harder woods for it. A ratio of course was dramatic in the nobel prize acceptance speeches. Roslyn is by then dead. So little people forget those no question hoping for price. 'cause they not give them to the dead they given to the living so the three man. None of them acknowledged her work public. What she gets is a footnote in morris wilkin so that's the asia and you would have thought on the occasion art a such a thing as the nobel prize. The woman is dead that there would have been case for little generosity. Not a hint of a three man. Just carry on as if she hadn't existed as she hadn't done the pioneering extra work. It wasn't a pool in shabby story. And there's plenty in the history of science strong views from sociologist. Hilary rose no matter which way you look at it though. The mystery of this dark lady is intriguing author. Brinda medics was so fascinated by rosalind franklin. That she's recently completed a comprehensive biography. He she is with robin williams. Rosen franklin's family very well off for intellectual whether or not they're very wealthy anglo jewish bankers they also had a publishing firm for the sons in the family who actually were inclined to banking rutledge and keegan. Paul you're very distinguished people very proud of their heritage and they trace their ancestry back to king david the founder of jerusalem. So i mean this is a family takes its ancestry seriously and so one of the problems i think was not so much her gender but class. She sounded aristocratic to them. She spoke terribly well very clipped and some people just hated that. And it's one of the many ingredients which actually made her disoriented and not as happy as she might have made a very clever little girl. And i mean as she was growing up quite small. She wasn't very clever. Little girl and i discovered family letter from her aunt mamie. Anyway she noticed rosalyn has a six year old and she rosalind is alarmingly clever. She does her sums for pleasure and invariably gets them right and i thought that alarmingly was very significant because roseland had three brothers but the fact that the girls should be the cleverest really did
The BreakPoint Podcast
International Panel Warns Us to Tap the Brakes on Gene Editing, but That Wont Stop Us
"Disasters are mostly by definition unavoidable, but we can often take basic steps to mitigate the damage such as not building in flood zones are on top of major faultlines mitigating manmade disasters. Hand is almost entirely avoidable, but quite often we don't because we're victims of our own ideologies and collective pride. For example, last week a panel of genetics experts issued a direct and stark warning against editing genes of human embryos that are destined for implantation. The panel, which consists of experts from ten different countries was jointly convened by the US National Academy of Medicine the US National Academy of Sciences and the UK Royal Society. The present state of gene editing said, the panel's report is simply too risky for both individual embryos and the human race as a whole while technologies such as Christopher are fairly precise and targeting and editing certain genes. They wrote recent ventures have demonstrated that fairly precise isn't. Good enough for instance, when researchers at the Francis Crick Institute in London US crisper recently to edit eighteen human embryos in order to study the role of a particular gene in the early stages of human development about a half of those embryos contain what they called quote major unintended at it. Now, that phrase is a euphemism for harmful mutations and genetic damage, the kind that could lead. To birth defects and even life threatening medical problems like cancer and not to mention could permanently enter the gene pool to other studies were also cited in the same report and one researchers attempted to correct gene mutation that causes blindness in the other the attempt was to prevent certain heart defects. However, researchers found that in both experiments, a significant percentage of the treated embryos suffered chromosomal damage one. Genetics expert described these failures this way if human embryo editing for reproductive purposes, germline editing were spaceflight. This new data would be the equivalent of having the rocket exploded at the launch pad before takeoff. Still once again, this new report focus only on the technical failures of gene editing. Once again, any discussion or even any acknowledgement of the many ethical questions inherent to this very idea of. Gene editing were completely avoided. So now and what's become far too typical of the scientific culture of our age in which philosophy ethics are completely divorced from technology and science research proceeds with an ethical framework of utilitarianism built on a philosophy of scientism or to put it more. Simply gene editing will continue because you know scientists are only real hope to solve problems and if we can do. Something we should, and so even though this panel admits that it could be years before the technical difficulties of gene editing are ironed out experiments will continue and should continue though quote initially limited to serious genetic disorders that are caused by DNA variants and a single gene and should be used quote on when the alternatives for having a biologically related child that is unaffected by the genetic. Disorder are poor. Look Scientific. hubris is indeed a very tough train to stop certainly an international panel of experts admitting that gene editing dangerous and unnecessary but we should proceed anyway as long as it's with caution that's not going to stop any eager scientists around the world, much less the governments and corporations who are funding them. Now, the sincere desire to eradicate dangerous diseases including genetic diseases understandable. It's even noble. The longing to heal is just a reflection of God's image in US ethically sound and medically safe treatment should always be pursued but we should never proceed without a full awareness of the human temptation to become like God is genesis three puts it determining good and evil after all couples are already genetically screening donor sperm to create designer babies and governments like China have. Already. Demonstrated their willingness to experiment on entire ethnic groups we are a world and too often h church that proceeds with the most invasive and inhumane technologies without adequate or in some cases any serious ethical reflection now, there is still time to prevent the potential manmade catastrophe of gene editing time itself however won't be enough unless we have the will to say,
Science Talk
How Cells Sense Oxygen Levels: Nobel Prize in Physiology or Medicine
"The Nobel Assembly Caroline Skins that has today decided to ward the two thousand Nineteen Nobel Prize in physiology discoveries of how south sounds and adapt to oxygen availability. Thomas Perlman Secretary of the Nobel Assembly shortly after five thirty am eastern time Greg Samantha was born in Nineteen fifty six in New York he performed his prize winning studies at Johns skains university in Baltimore where is still active Sir Peter Ratcliffe was born in Nineteen fifty four in Lancashire you're in the UK he performed his prize winning studies at Oxford University and he's continuing to do his research soared university and he's also at Francis Crick Institute in London and William Calin born in Nineteen fifty seven in work he performed his price winning studies at Dana Farber Cancer Institute in Boston we're still active in his own lab yeah I will not turn to professor Roundell Johnson a member of the Nobel Assembly who will describe some detail and background binder works so please ramble this year's Nobel prize is awarded for determining how oxygen levels are sensed by cells oxygen is essential for life and is used by virtually all animal cells in order to convert food to usable energy however the amount of engine available to cells tissues animals themselves can vary greatly this prize is for three physician scientists who found them switch that regulates how our cells adapt when oxygen levels drop the most fundamental use of oxygen by the cell is to convert food to usable energy just as a candle needs the right amount of oxygen to burn cleanly cells need to adjust their metabolic rates based on how much oxygen they have available to them this allows each cell and indeed our bodies to efficiently and safely burn fuel so as to create heat do work and build new tissues cells and tissues are constantly experiencing changes in oxygen availability as an embryo grows develops as muscles work the oxygen available changes as the tissues themselves change cells need a way to adjust to the amount of oxygen they have while still doing their important jobs sometimes oxygen levels change across the entire body such as when we high altitudes and sometimes they change and very small parts of our bodies such as when we get a wound that interrupts the local blood supply this triggers adaptive process called the hypoxia response which in turn can induce processes in the body as diverse as new blood vessel formation or genesis new red blood cell formation or rith rope and metabolic adaptations of cells including by Colossus before things get too complicated I want to jump to an interview Randall. Johnson did after the Nobel announcements Johnson's research on the effects of low oxygen so he really knows is this stuff he spoke to an unidentified interviewer but based on the programs in past years I believe she was Swedish journalist Joanna rose this use your water in the discovery of cells sense and adapt to oxygen availability. What does this mean well it's basically a price that says in your cell if you're an animal cell you have to always have some level of oxygen almost all cells use it to do there pollick processes and basically it is just like a candle burning or any other kind of furnace or engine you are burning things in order to make heats in order to make Gede and that's really what we do of course we need oxygen or do those things the problem is cells inside three-dimensional structure like the body are just getting different amounts of oxygen can depend on different levels and blood flow can depend on the fact that the the tissue itself might be using a lot of oxygen at any given time my brain is probably using fair amount right now my heart because it's eating a bit faster and so that's maybe got sort of its using oxygen and if I'm lying down and sleeping and so the because the cell has very tightly regulated little furnace in it it has to adjust to these different levels of oxygen fine-tuned way and if it does badly it can even be fatal for the cell so this is really the prizes for this sort of almost like a reestablish or a thermostat for the oxygen levels a damper that you'd have on your furnace to let in more or less oxygen at any given time so it's just right the flame
60-Second Science
Nobel in Physiology or Medicine for How Cells Sense Oxygen Levels
"This is scientific Americans sixty seconds science. I'm Steve Mirsky then Nobel family at Karolinska Institute today decided to ward the two thousand Nineteen Nobel Prize in Physiology or medicine jointly to William Oxygen Availability Thomas Perlman Secretary of the Nobel Assembly shortly after five thirty a m eastern time Greg Samantha was born else oxygen is essential for life and is used by virtually all animal cells in order to convert food to usable energy however years three laureates have greatly expanded our knowledge of how physiological response makes life possible for an in-depth listen about the the amount of oxygen available to cells tissues animals themselves can vary greatly this prize for three physician scientists who found back with potential drugs used to treat anemia and to treat some forms of cancer these fundamental findings have greatly increased outstanding of how the body adapts to change and applications of these findings are already beginning to affect the way medicine is practiced this the molecular switch that regulates how ourselves adapt when oxygen levels drop. Applications of these findings are already beginning to make their way to the Clinton winning studies at Oxford University and he's continuing to do his research that Oxford University and he's also at the Francis Crick Tiv- Sir Peter Ratcliffe was born in Nineteen fifty four in Lancashire in the UK. He performed his price Dana Farber Cancer Institute in Boston where is still active in his own lab Karolinska Institute researcher Randall Johnson Studies the effects of Thousand Nineteen Nobel Prize in physiology or medicine look for these scientific American science talk podcast later today for scientific Americans six