15 Burst results for "County Donegal"
WNYC 93.9 FM
"county donegal" Discussed on WNYC 93.9 FM
"Forecast on the way after headlines from the BBC. This is WNYC, FM HD and a.m., New York. Welcome to NewsHour from the BBC World Service I'm John donnison. Today we'll get the latest on the kerch bridge attack which targeted a key link between Russia and annex Crimea. It was an astonishingly audacious attack, probably one of the more stunning efforts by the Ukrainian military since the war began. We'll get live reaction from Ukraine and look at the strategic and symbolic significance. We'll have the latest from Thailand as funerals get underway for those killed in Thursday's nursery attack. Also, why New York has declared a state of emergency as homeless shelters risk being overwhelmed, as migrants from central and Latin America are bust into the city. We were facing a rising number of people in shelter before these migrants started to come. So the shelter system was already pretty full. Also, we'll hear about the end of the line for the Paris metro paper ticket. That's all to come. First a bulletin of world news. Hello, this is the BBC News with Fiona McDonald. Hours after a huge explosion damaged Russia's only bridge to the occupied Crimean Peninsula, president Putin has ordered his FSB Secret Service to tighten security there. He's also instructed it to take steps to protect gas and electricity supplies to Crimea. Paul Adams reports. Coming on the back of weeks of mostly good news from the battlefront, the site of the crippled burning kerch bridge is a massive additional boost to morale. How did it happen? This evening a presidential adviser here in Kyiv blamed infighting and rivalry in Moscow as branches of the security establishment seek to blame each other for their failures on the battlefield. But a former senior British Army explosives expert told me it looked more like a highly successful Ukrainian sabotage operation. Either way, Russia may now find it harder to send heavy equipment to its already beleaguered troops in southern Ukraine, some road traffic has already resumed and the Russian authorities say a train will cross tomorrow, but Vladimir Putin's problems, it seems just keep multiplying. Russia has a new commander in overall charge of the war in Ukraine. General Sergei kin, heads Russia's aerospace forces, and has overseen operations in southern Ukraine since the summer. His appointment follows a string of Russian defeats, including in the south. General Cerro vican came to prominence 5 years ago when he commanded Russian troops in Syria. Iranians have defied a growing security crackdown to take to the streets as anti government demonstrations enter a fourth week. There are reports that at least three people have been killed. Here's Sebastian usher. If there were any doubts as to whether the momentum of the protests could be sustained, today's demonstrations in many cities across Iran have provided a robust response from shuttered streets and cities in the Kurdish region where shops have been on strike to high school girls yelling their defiance at the school gates. There seems to have been a major effort by Iranians, angry with their rulers to show that they won't allow their voices to be silenced. One video of its gone viral shows an elderly man using a walker shaking his fist in the air and shouting for freedom. The Irish prime minister micho Martin is called an explosion and county donegal which killed ten people and unspeakable tragedy, the blast increased loch destroyed a petrol station. Here's Chris page. Most of those who died were believed to have been in the garage shop or some flats above. The building collapsed onto the four court. It people were taken to hospital one is in a critical condition. Of the ten who died four were men and three were women. A teenage boy and girl were killed, so was a younger child. All were from the local area. Police superintendent Liam garrick said it wasn't clear what caused the explosion, but no crime was suspected. World news from the BBC, and in New York, I'm Tiffany Hansen for WNYC news. Big moneyed interests have been pouring millions of dollars into New York's gubernatorial race in the final stretch before election day. Here's WNYC's John Campbell. Democratic governor Kathy hochul raked in $11 million since July, while Republican challenger Lee zeldin took in about 6 million. That's according to the latest disclosure documents filed late Friday. Hokus campaign accepted big donations from the New York City real estate industry, and even Hollywood royalty like director Steven Spielberg and producer Jeffrey katzenberg. Zeldin is getting major support from Ronald louder. He's an heir to the Estee Lauder cosmetics fortune. Louder is pumped in more than $3 million into a super PAC supporting the Republican candidate. Election day is November 8th
AP News Radio
10 Dead in Gas Station Explosion in Ireland, Officials Say
"Several people have died from a gas station explosion in northwestern island the explosion happened increased low in county donegal the force of the blast leveled the gas station building which holds the main shop in the post office for the village The day after the blast service workers came through piles of rubble looking for people who are still missing Irish police spokesman Lee and Gary sponsored local community has been overwhelming They were dealing in a situation in their village in their local people their neighbors they turned out in great numbers and gave great assistance to the emergency services And it's remarkable and admirable as to how they reacted Iris police officer superintendent David Kelly milford said the blast has shocked the nation This is a tragedy for our community
Travel with Rick Steves
"county donegal" Discussed on Travel with Rick Steves
"At all, really. I mean, people in northern have suffered enough. I love it. You got a quirk in here. Did you understand what he said Rick? I didn't know. It was very peculiar. It's not like Richard, I think. Corkman. I've heard that county cork is a frame of mind or what is it about a state of mind? What's cork to you? There was a T-shirt produced recently. It said, Irish by birth, cork by the grace of God. Oh, isn't that nice? Stevens on the rest of us are all in the background almost thrown up when we hear all this stuff. We do admire the Cartman for their pride. There's no doubt about that. And Michael Collins came from court. I mean, he's sort of the great the patriotic rebel. Well, not all the country think Collins is great. That's half the country wouldn't have thought. But we do admire the Kirkland, but everybody loves to beat them and poke fun at them, but they're definitely grateful. I remember meeting a carc businessman once and I said, you're a businessman and car key. So I'm not a businessman. I am a merchant prince. Is that not the worst attempt at a carcass? I think when Steven does an Irish accent, as an Irish man, he does a quart cacin, don't you? I think I do a car crack. He doesn't think I do it right now. I met a car at my once we were talking about the car soccer player Roy Keane who plays in midfield. I said he's a great midfielder. He said, he's not a midfielder. He's a midfield general. You know, there's delusions of grandeur there. But I have to say in fairness, most of our great patriots and sports teams have all come from kraken. In Ireland, if you're good at Gaelic football, you're usually used as a hurdling. And if you're good at hurling, you're usually used as a Gaelic football, you know, your country. Hurling a lot of Americans might think that's barfing. Oh, sorry, that's our native ancient sport played with sticks at a ball, not throwing up for it. When we think hurling, no, but we should know that when you go to, how would you describe hurling the sport? Well, first of all, it's the fastest field sport. It seems to me, I would say it's like airborne hockey. One of the fortunate to come from cork, we're both good at hurting, which is our game and foot and garlic football. Herding is the instruments that use are made of ashes like a flat baseball bat. Usually the length differs on the height of the guy. It's hard to describe it. I suppose it's from time to time people describe it as the cross. But I'm sure a lot of the horrors would prefer to be playing lacrosse sometimes because it wouldn't be as physical or thirsty. I don't know the rules, particularly, but it seems to me it's like you could call it like airborne like hockey, where you throw the puck. Yes. Well, you can throw it, you have to hit it with the Hurley. Muhammad Ali watched the final once in our prime minister turned to him and said, would you like to be out there with a stick Muhammad? And he said I'd hate to be out there without one. So that's how fierce great warrior came from. If you get a chance to see her name match 29 Ireland, I would highly recommend it. We're talking about just that conviviality of Ireland and, you know, you can go into a pub. And when you go to pub, you don't have to have a theme or a reason you just go there and you know you're going to get into some good conversation. Do you sit at the bar if you want to connect with people more or what's your tip? I would generally sit at the Barrett. I've never been to a Pope in anywhere in Ireland that if I sat at the somebody didn't say hello or Hawaii or where you came from. And then if you say cork, you've got something to talk about. Well, if I said if it was outside the court, I have to defend myself from the beginning. Verbally I'm not physically defend myself because some people don't consider New Zealanders have the same kind of thing going on. Exactly. It's like the Aussies and the kiwis. What about the Kerry people? Because that's a big powerful county in the south, isn't it? Yeah, well, there is our travels. The Cartman don't like to carry man and vice versa. They are the greatest team ever, Gaelic football, they've won. I think on average every three years since the game was created in the 1890s. All Ireland is one in football. My county donegal has got two, so everybody wants to beat the carrier man. So it's like the New York. It's like the Yankees in the midst. What's your county, Stephen? My country is, well, I was born and dairy, but I went to school in Donny golf. So I cheer for both teams, but I've done all we're playing Derry, I'd go for donegal. All right. Now Ireland's famous for its blessings and also its insults. It's interesting because you got these Irish blessings. Yes. How would you bless a person from county Kerry? Because you're from county court. With a what? With a hurdle. What's a hurricane? That's the stick that we used to play hurry. Oh, the stick. You bless him on the bump of the head. Okay. How would you bless somebody? I'd like to say we had a great comedian. Once you used to always say, may your God be with you so I always like to say that to the mayor, God be wishing that you always see them take a blank stare, what did we just say? May your God be with you? Well, the one that I always lived by is may you be in heaven and Nora before the devil knows you're dead. That's a nice one. That's a very nice one. To me, it's very complimentary. When Steven's trying to do the county cork actually 7 big difficulty. How do accents vary in Ireland? It's amazing for such a small country that each county has its own particular accent. The Johnny gallon where Steve comes from is probably an abuse of the linguist language to be honest, because they don't pronounce their words properly and you're going to put up with that? No, I'm just waiting to get the chance to intervene here. Let's see a couple of years ago. The Irish accent was voted the sexiest in the world. And then the donegal accent was voted the sexiest in Ireland. So therefore, they're just about obviously their language is better looking than their men. And donegal, where I'm from, it's very famous for its potatoes. You see, and my country donegal has kind of great rivals for growing potatoes where the potato counties. Was that right? There's counties that are famous. I thought potatoes were everywhere, but they used to be everywhere, but no, these days are kind of restricted to they're the two big producers. And in donegal, I've heard that we have 56 varieties of potato. Now, I've heard that dog and can talk about potatoes in the same way that a French man would describe a grip. Like a Chardonnay. We like a dry, fluffy potato, you're driving through donegal and there's big signs on the side of their own saying, balls of flour for sale, because that's what they look like once they're cooked. You know, they're like baking balls. And you'll see signs saying powdery bowls for seal. Bragging about their potatoes. But we call potatoes parties. Pee you IES parties. And there's a poem we used to learn at school and we'd like to eat the potato seat with the skins on. So the poem was where do you come from? How was your party? How do you eat them? Skins and all. Don't you choke? Not a towel. Hardly this stuff was Shakespeare. I saw a bunch of little girls selling potatoes on the side of the road one south of Dublin and there was some joke about the queen. Actually, there's a type of potato and car called queens. Is that it? And while the potato was originally they were selling queens. I think that correct me here, maybe, but the potato was actually originally called the British Queen. But after independence, we dropped the British out of the queen, just called the queen. Yeah, because once we had you up to the north, remember, there was British queens for sale and then we died. There was queens for sale. And then I had to remember one day it said to me, all these signs on the side of the road. She said, I was explaining the types of potato because there's pinks for sale as well. It's a very famous and she said to me, whose dog daily? And I said, that's their fresh potatoes for God's sake. Their dog every day. The sign said, potatoes dog daily, and she said to me, whose dog daily. That's.
Planet Mikey
"county donegal" Discussed on Planet Mikey
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Mon Carnet, l'actu numrique
"county donegal" Discussed on Mon Carnet, l'actu numrique
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As It Happens from CBC Radio
"county donegal" Discussed on As It Happens from CBC Radio
"One homeowner compared the blocks of his house to a flaky. Cereal another worried about her place. Collapsing and sent her son regularly asked if it was safe to go to bed at night. Just two of the stories that people whose homes were built with faulty blocks of told the guardian newspaper. Thousands in ireland are affected by the so-called mica scandal and campaigners say it's ruined lives tomorrow those campaigners who were demanding one hundred percent redress from the government are headed to dublin. Noel noon and his family are going to the demonstration. Mr noon has worked with the mica action group. We reached him in quigley's point in county donegal ireland. No i know you moved into your forever home back in two thousand and six and when did you start to notice things were not quite right. carl would've been around two thousand eleven probably after we had probably had for quite some time. Here so yeah. The democrats can opened up a lot more on. We end up. Having moss things growing the practice. Oh heavens you eventually had an engineer come out to your place. What did you learn so yeah. We got a struggling ear. He can and some of the render hud falling off the hustle. Some of the actual blocked were already exposed from that way. Rebel to visibly see cracks in the block itself. It wasn't actually in the mortar. That was tylenol. The blocks together so the blocks were physically cracking but the mortar was still intact. So you could visibly see the cracks rolling through the high enrolling through the render. And then you come to the exposed and you can see those cracks. Continue up through the the blocks and then on through the render as well. There were web like kraken at that stage. The engineer kind of his character was able to pick the block away. Such was his car keys. A little bit of force from that was kind of they had not had seen somewhere properties similar characteristics and believed blocks to be effective these these concrete blocks these concrete blocks that were manufactured locally macron At the time we built does. It's now estimated that there are twenty thousand homes with these faulty blocks. Is that right. yeah i would. I would put the estimate and donegal loan probably close to cancellation but it in the past couple of months last six months mayo has a a quite a few number of outcomes affected on county sligo clare lemrick temporary all how homes that are showing signs of defacto blocks from dod era arrived in the celtic tiger as we would call norrland when there was when there's a lot there was a lot of construction going on the new new housing. We've done some stories in the past about some pretty bad construction problems but in this case. What you're discovering was that there was excessive amounts of a mineral known as mica and that was In these concrete blocks and that was what was making them into as one gentleman called was like having weetabix as the bricks house. Yes that's that's basically what it came down to it and again kind of going back to the celtic tiger. Even today standards the building. Sounders on our Starring because you know companies manufacture. These blocks are are self regulating and self certifying third product to a standard. You know there's no quality control. Or the local councils harland dear to you know audit uninspected quarries on a regular basis to make sure the product is foot for purpose. Can't live in these houses right you. You moved out. You had some place to live. A family member can provide but what about all the people in these other houses. What effect is it. Having on them they have houses. That are dangerously defective. Yeah i you know. Just recently i become to a local family. They're less than five miles away. They have a couple of kids have special needs and they just got confirmation as well as that. There has to be demolished. So they're not looking at you know there's no word locally to rent because horses have make or you know there's just there is no available to spare homes but these guys are actually looking at buying a caravan to put on sites or malign home to put on site to live and possibly for twelve months possibly twenty four months Was to children with special needs. Were fortunate i nor predicaments knock grit. I wouldn't wish it on my worst enemy but you know there there's some homeowners there it just beggars belief that this has been a go on for so long. The government has offered various schemes to cover the cost of repair Understand very complex documents need to be filled out and they don't cover the full cost of what it would actually be to build a house so you are now you and others are well tomorrow. You're going to March on dublin. To demand compensation what does the government need to do for you and the others the the card scheme. That's down just not feasible for two of myself or any other family. That's trying to rebuild stipulated ninety. Kemp's game the government pay ninety percent of it and we would pay percents for a better mental var homes but and in effect when you when you got targeted and like myself when i got into this game and got approved and i go to contractor to get a price from the contractor. You know the prices. I'm getting back are nowhere near what the government allocates for for me rebuild and i'm looking at possibly one hundred twenty eight thousand two hundred fifty thousand to rebuild my home on top of what the government would give me. I told her. I don't house that and come capacity to tell the second mortgage to pay for that and it was not our fault. You know we didn't know when we go out and buy defective products so yet tomorrow. It's time to let the government know. This probably won't go away. We won't go away. It's gotten worse if it takes us to call adult again. We'll call them in bigger numbers again. I do so tomorrow we will. Have you know one of the largest protests and our history and current teens to descended on dublin because defeating appears the you know the government just wanting to leave donegal the and know. I'm so sorry this is happening to you. I think people listening to this would I just think it's a nightmare. And i hope this gets straightened out. And i hope you and your kids can have a place to live You can call your own. And i appreciate you speaking with us. Thank you know. Problems are thank you. Thank you for your sentimental good goodnight. No no noone is headed to dublin tomorrow to call on the government to provide more support for people like him affected by the mike scandal. We reached him in quigley's point ireland..
Liberty Talk FM
"county donegal" Discussed on Liberty Talk FM
"If you're in our ego now, But keep listening as we have Tom on the line with us. So when you get into, um the accommodations at the Golden Eagle and I have to tell you you have made the Irish bar sounds so enticing to me. And I have We've been home from Ireland now, uh 12 13 14 almost 15 months and I needed those viral and then I'm not going to get it this year, so I may just find Wango my way your way, Tom. Um, just so I can feel like I've gone someplace really far away. And, uh, and atmosphere that feels Irish, because that's terrific. Is there any Irish in you? Oh, yes, I'm from Boston, originally. And that's uh salmon family as connections there and we we do go quite a ways back in Ireland. What part of Ireland where your folks from, you know, kind of all over we were sprays. Spaced out there we were. We were We were famine, refugees. We came over in 18 45. So what You say you were salmon refugees? What does that mean? The potato famine in Ireland. Okay, so you would have been from Galway or Connemara or Donnie Gaul. Exactly what your family into the salmon fishing business at all is, as I understand that that's the genesis of the name and has one of two meanings either your salmon farmer or salmon poacher. Um so it's that you could have either had a very ethical or So much shady background with the name But I do know that my great great grandfather was a butcher and his son was a carpenter so that my family does have a history of being tradesmen. Well, my guess is that they came from either county, Mayo or county, Potentially county, Galway, but county Mayo, um or county Donegal. And they were fishing on the Moya River M o Y, as in Yellow River, because that is loaded with salmon, and there are wonderful places along the river that you can either stay at hotels that have grown up along there or near close enough in the nearby But it's funny. You should mention, you know, um Salmon. I don't know fishermen, poachers or breeders or something, or, you know the good side of that industry. Or, you know the thieves, Uh, because my grandfather's family Um, prior to his arriving in America in 19. Oh, five. Um they bred horses and any time I tell people they play the horses, I will often get a wise guy say or else they were horse thieves. It's like, no, thank you for that. Um, what is it? That you couldn't share with my audience and about a minute. That will encourage them to put Bedford, Pennsylvania and the Golden Eagle in on their must visit list for a small.
KQED Radio
"county donegal" Discussed on KQED Radio
"CRISPR into patients bloodstreams to try and help them and it appears to have worked. NPR health correspondent Rob Stein has more Patrick Doherty had always been really active, trekking the Himalayas, hiking trails in Spain, but he suddenly started feeling pins and needles in his fingers and toes, and his feet got cold. And then one day, he noticed he was running out of breath just walking his dog in County Donegal in Ireland, where he lives and kind of getting a bit breathless going up. Uh, a small, l said here in Donegal, which which There are many. So I realized something was something was wrong. Something was wrong. Turns out he had inherited a rare but devastating disease that killed his dad, known as amyloid doses. A deformed protein was damaging parts of his body like nerves in his fingers and toes and his heart. He had watched two uncles and neighbours also die awful deaths from amyloidosis. It's just dreadful. So Doherty, who's 65 was thrilled when he found out that doctors were testing. A new way to treat amyloidosis using CRISPR, which allows scientists to make very precise changes in DNA. I thought fantastic, I couldn't believe my look crisper has already started helping patients suffering from the blood disorders, sickle cell disease and beta thalassemia, and doctors are trying to use it to treat cancer and restore vision. Two people blinded by a rare genetic disorder, but those experiments involved taking cells out of the body. Editing them in the lab and infusing them back in or injecting CRISPR directly into cells that need fixing. The study. Doherty volunteered for is the first in which doctors are simply infusing the gene editor and letting it find its own way to the right gene in the right place in this case, a gene and cells in the liver Pumping out the destructive protein. John Leonard is the CEO of Antalya Therapeutics, the company sponsoring the study. This is the first example in which CRISPR CAS nine is injected directly into the bloodstream, in other words, systemic administration where we use as a way to reach a tissue that's far away from the site of injection and very specifically edit particular disease causing genes, and it looks like it worked. Doctors infuse billions of micro This topic structures known as nanoparticles into Doherty and five other volunteers. Each nanoparticle carried the genetic code for the CRISPR gene editor. The nanoparticles made their way to deliver And unleashed an army of crisp routine editors, which honed in on the target gene to disable it. Within weeks, the levels of bad protein causing the disease plummeted. It's amazing. It's uh, you know, it's it's phenomenon, It really is excited. Dr. Julian Gilmore is leading the study at the University College London. This has the potential to Completely revolutionized the outcome for these patients who have lived with this disease in their family for many generations, you know, it's decimated some families that I'm that I've been looking after. So now this is this is amazing. The patients will have to be followed much longer, and many more patients will have to be treated to make sure the treatments as safe as it looks and to determine how much it's helping patients. But Gilmour says the approach could help those struck by a far more common version of the Disease and provides the first good evidence that CRISPR could be used like this to treat many other, much more common diseases for which taking cells out of the body or directly injecting CRISPR isn't realistic, like heart disease, muscular dystrophy and maybe even brain disorders like Alzheimer's. This is a wonderful day for the future of gene editing as a medicine. Theodore Urnov is a professor of genetics at the University of California, Berkeley. What's striking about These new data is not merely the evidence of safety and efficacy but the avenues or highways. It opens up for us in terms of traveling to new destinations in the world of genomic medicine, he says. It's a new world. We as a species are watching this remarkable new show called R gene edited future. For his part, Patrick Doherty is thrilled. I feel I feel fantastic, feel fantastic. He started feeling better within weeks of the treatment. Definitely notice an improvement in terms of mobility, My my, my heart. They move in a boat. I'm walking again. I do 15 35,000 steps a day and weekend I got again. He'll walk in with a dog. Doherty's looking forward to the future again. I'm really thankful for it really thankful for, And he hopes CRISPR will help some of his friends and relatives avoid the terrible fate. His father, uncles and friends suffered. Rob Stein. NPR news This is NPR news over to Joe McConnell at the traffic desk at 7 19 on KQED Jail Reporting of art delay. The 10 minute delay on the various align heading in the Richmond and Daly City directions because of some police activity at Hayward and South Hayward stations on the freeways. It's been pretty uneventful. Just a few bender a fender benders of South Adedy before autumn, a park where it looks like that one has cleared still heavy from Thornton, but picking up up to 25 30 Miles an hour now. Did the South I 2 to 37. There might be some metal debris in the right lane..
KCRW
"county donegal" Discussed on KCRW
"CRISPR into patients bloodstreams to try and help them and it appears to have worked. NPR health correspondent Rob Stein has more Patrick Doherty had always been really active, trekking the Himalayas, hiking trails in Spain, but he suddenly started feeling pins and needles in his fingers and toes and his feet that cold And then one day, he noticed he was running out of breath just walking his dog in County Donegal in Ireland, where he lives. I'm kind of getting a bit breathless going up a small hill side here in Donegal, which which there are many. So I realized something was something was wrong. Something was wrong. Turns out he had inherited a rare but devastating disease that killed his dad, known as amyloid doses. A deformed protein was damaging parts of his body like nerves in his fingers and toes and his heart. He had watched two uncles and neighbours also die awful deaths from amyloidosis. It's just dreadful. So Doherty, who's 65 was thrilled when he found out that doctors were testing. A new way to treat amyloidosis using CRISPR, which allows scientists to make very precise changes in DNA. I thought fantastic, I couldn't believe my look crisper has already started helping patients suffering from the blood disorders, sickle cell disease and beta thalassemia, and doctors are trying to use it to treat cancer and restore vision. Two people blinded by a rare genetic disorder, but those experiments involved taking cells out of the body. Editing them in the lab and infusing them back in or injecting CRISPR directly into cells that need fixing. The study. Doherty volunteered for is the first in which doctors are simply infusing the gene editor and letting it find its own way to the right gene in the right place. In this case, a gene and cells in the liver pumping out the destructor of protein. John Leonard is the CEO of Antalya Therapeutics, the company's sponsoring the study. This is the first example in which CRISPR. CAS nine is injected directly into the bloodstream, in other words, systemic administration where we use it as a way to reach a tissue that's far away from the site of injection and very specifically edit particular disease causing genes, and it looks like it worked doctors and views billions of microscopic structures known as nanoparticles into Doherty and five other volunteers. Each nanoparticle carried the genetic code for the CRISPR gene editor. The nanoparticles made their way to deliver and unleashed in Army of CRISPR Gene editors, which honed in on the target gene to disable it. Within weeks, the levels of bad protein causing the disease plummeted. It's amazing. It's uh, you know, it's it's It's phenomenal. It really is exciting. Doctor Julian Gilmore is leading the study at the University College London. This has the potential to Completely revolutionized the outcome for these patients who have lived with this disease in their family for many generations, you know, it's decimated some families that I'm that I've been looking after. So this is this is amazing. The patients will have to be followed much longer, and many more patients will have to be treated to make sure the treatments as safe as it looks. And to determine how much it's helping patients. But Gilmour says the approach could help those struck by a far more common version of the disease and provides the first good evidence that CRISPR could be used like this to treat many other much more common diseases for which taking cells out of the body or directly injecting crisper isn't realistic, like heart disease, muscular dystrophy and maybe even brain disorders like Alzheimer's. This is a wonderful day for the future of Gene editing as a medicine feared. Urnov is a professor of genetics at the University of California, Berkeley. What's striking about these new data is not merely the evidence of safety and efficacy. But the avenues or highways, it opens up for us in terms of traveling to new destinations in the world of genomic medicine, he says. It's a new world. We as a species are watching this remarkable new show called Gene edited future. For his part, Patrick Doherty is thrilled. I feel I feel fantastic. I feel fantastic. He started feeling better. Within weeks of the treatment. I definitely noticed an improvement in terms of mobility, my my heart moving about. I'm walking again. I do 15 35,000 steps a day and weekend I go up again Hill Walking with a dog. Doherty's looking forward to the future again. I'm really thankful for it really thankful for it, And he hopes CRISPR will help some.
KQED Radio
"county donegal" Discussed on KQED Radio
"CRISPR into patients bloodstreams to try and help them and it appears to have worked. NPR health correspondent Rob Stein has more Patrick Doherty had always been really active, trekking the Himalayas, hiking trails in Spain, but he suddenly started feeling pins and needles in his fingers and toes and his feet that cold And then one day, he noticed he was running out of breath just walking his dog in County Donegal in Ireland, where he lives and kind of getting a bit breathless going up a small l said here in Donegal, which which there are many. So I realized something was something was wrong. Something was wrong. Turns out he had inherited a rare but devastating disease that killed his dad, known as amyloidosis. A deformed protein was damaging parts of his body like nerves in his fingers and toes and his heart. He had watched two uncles and neighbours also die. Awful deaths from amyloidosis is it's just dreadful. So Doherty, who's 65 was thrilled when he found out that doctors were testing. A new way to treat amyloidosis using CRISPR, which allows scientists to make very precise changes in DNA. I thought fantastic, I couldn't believe my look crisper has already started helping patients suffering from the blood disorders, sickle cell disease and beta thalassemia, and doctors are trying to use it to treat cancer and restore vision. Two people blinded by a rare genetic disorder, but those experiments involved taking cells out of the body. Editing them in the lab and infusing them back in or injecting CRISPR directly into cells that need fixing. The study. Doherty volunteered for is the first in which doctors are simply infusing the gene editor and letting it find its own way to the right gene in the right place in this case, a gene and cells in the liver Pumping out the destructive protein. John Leonard is the CEO of Antalya Therapeutics, the company's sponsoring the study. This is the first example in which CRISPR CAS nine is injected directly into the bloodstream. In other words, systemic administration. Where we use that as a way to reach a tissue that's far away from the site of injection and very specifically edit particular disease causing genes, and it looks like it worked. Doctors infuse billions of microscopic structures known as nanoparticles into Doherty and five other volunteers. Each nanoparticle carried the genetic code for the CRISPR gene editor. The nanoparticles made their way to deliver and unleashed in Army of CRISPR Gene editors, which honed in on the target gene to disable it. Within weeks, the levels of bad protein causing the disease plummeted. It's amazing. It's uh, you know, it's it's phenomenon. It really is exciting. Doctor Julian Gilmore is leading the study at the University College London. This has the potential to Completely revolutionized the outcome for these patients who have lived with this disease in their family for many generations, you know, it's decimated some families that I'm that I've been looking after so This is this is amazing. The patients will have to be followed much longer, and many more patients will have to be treated to make sure the treatments as safe as it looks and to determine how much it's helping patients. But Gilmour says the approach could help those struck by a far more common version of the disease and provides the first good evidence that CRISPR could be used like this to treat many other Much more common diseases for which taking cells out of the body or directly injecting crisper isn't realistic, like heart disease, muscular dystrophy and maybe even brain disorders like Alzheimer's. This is a wonderful day for the future of gene editing as a medicine. Theodore Urnov is a professor of genetics at the University of California, Berkeley. What's striking about these new data? Is not merely the evidence of safety and efficacy but the avenues or highways. It opens up for us in terms of traveling to new destinations in the world of genomic medicine, he says. It's a new world. We as a species are watching this remarkable new show called R gene edited future. For his part, Patrick Doherty is thrilled. I feel I feel fantastic, feel fantastic. He started feeling better. Within weeks of the treatment. I definitely notice an improved In terms of mobility, my my heart moving about. I'm walking again. I do 15 35,000 steps a day and weekend I got again Hill Walking with a dog. Doherty's looking forward to the future again. I'm really thankful for it really thankful for And he hopes crisper will help some of his friends and relatives avoid the terrible fate. His father, uncles and friends suffered. Rob Stein. NPR news This is NPR news. Morning edition, Right here on members supported KQED Public radio for Monday. Good morning. Thank you for listening. And thank you So much for your continued support of KQED. I'm Dave Freeman and Joe McConnell. Also here on Monday, reporting Bay area traffic conditions as we start the morning with Highway 12 around Fairfield. Good Monday, Joe Other Dave. Good morning. Just one trouble spot. It's westbound 12 past 80 near Red Top road. There's a report.
WNYC 93.9 FM
"county donegal" Discussed on WNYC 93.9 FM
"CRISPR into patients bloodstreams to try and help them and it appears to have worked. NPR health correspondent Rob Stein has more Patrick Doherty had always been really active, trekking the Himalayas, hiking trails in Spain, but he suddenly started feeling pins and needles in his fingers and toes, and his feet are cold. And then one day, he noticed he was running out of breath just walking his dog in County Donegal in Ireland, where he lives. I'm kind of getting a bit breathless going up a small hill side here in Donegal, which which there are many. So I realized something was something was wrong. Something was wrong. Turns out he had inherited a rare but devastating disease that killed his dad, known as amyloid doses. A deformed protein was damaging parts of his body like nerves in his fingers and toes and his heart. He had watched two uncles and neighbours also die awful deaths from amyloidosis. It's just dreadful. So Doherty, who's 65 was thrilled when he found out that doctors were testing. A new way to treat amyloidosis using CRISPR, which allows scientists to make very precise changes in DNA. I thought fantastic, I couldn't believe my look crisper has already started helping patients suffering from the blood disorders, sickle cell disease and beta thalassemia, and doctors are trying to use it to treat cancer and restore vision. Two people blinded by a rare genetic disorder, But those experiments involved taking shells out of the body, editing them in the lab. And infusing them back in or injecting CRISPR directly into cells that need fixing the study door. Eddie volunteered for is the first in which doctors are simply infusing the gene editor and letting it find its own way to the right gene in the right place. In this case, a gene and cells in the liver pumping out the destructive protein. John Leonard is the CEO of Antalya Therapeutics, the company sponsoring the study. This is the first example in which CRISPR cas nine, is it Injected directly into the blood string in other words, systemic administration where we use it as a way to reach a tissue that's far away from the site of injection. Very specifically edit particular disease causing genes, and it looks like it worked. Doctors infuse billions of microscopic structures known as nanoparticles into Doherty and five other volunteers. Each nanoparticle carried the genetic code for the CRISPR gene editor. The nanoparticles made their way to deliver and unleashed an army of CRISPR gene editors, which honed in on the target gene to disable it. Within weeks, the levels of bad protein causing the disease plummeted. It's amazing. It's uh, it's phenomenal. It really is exciting. Doctor Julian Gilmore is leading the study at the University College London. This has the potential to Completely revolutionized the outcome for these patients who have lived with this disease in their family for many generations, you know, it's decimated some families that I'm that I've been looking after so This is this is amazing. The patients will have to be followed much longer, and many more patients will have to be treated to make sure the treatments as safe as it looks and to determine how much is helping patients. But Gilmour says the approach could help those struck by a far more common version of the disease and provides the first good evidence that CRISPR could be used like this to treat many other Much more common diseases for which taking cells out of the body or directly injecting crisper isn't realistic, like heart disease, muscular dystrophy and maybe even brain disorders like Alzheimer's. This is a wonderful day for the future of gene editing as a medicine theater, Urnov is a professor of genetics at the University of California, Berkeley. What's striking about these new data? Is not merely the evidence of safety and efficacy but the avenues or highways. It opens up for us in terms of traveling to new destinations in the world of genomic medicine, he says. It's a new world. We as a species are watching this remarkable new show called Gene edited future. For his part, Patrick Doherty is thrilled. I feel I feel fantastic. I feel fantastic. He started feeling better. Within weeks of the treatment. I definitely notice an improvement in terms of mobility, my my heart moving about. I'm walking again. I do 15 35,000 steps A day weekend I got again Hill Walking with a dog. Doherty's looking forward to the future again. I'm really thankful for it really thankful for it, And he hopes CRISPR will help some of his friends and relatives avoid the terrible fate. His father, uncles and friends suffered. Rob Stein. NPR news This is NPR news. This is W. N. Y. C. Later on morning edition. A dangerous heatwave bakes the Pacific Northwest. We are entering record shattering days of heat here, where our overnight lows are actually about where our typical highs are. We'll get the latest from Portland, where many residents don't have air conditioning coming up in about 15.
Up First
"county donegal" Discussed on Up First
"Bipartisan one. Point two trillion dollar infrastructure deal is back on track after president biden walked back and apparent veto threat to get all that right so remember last week. President biden said he would not sign this infrastructure. Bill which he supports unless it was sent to his desk with a separate spending measure. That would have money for childcare. Healthcare climate change and a bunch of other things and then over the weekend. The president issued a statement saying he hadn't meant to link the two bills. Here's ohio republican. Senator rob portman on. Abc this week responding so it was. It was a surprise to say the least that those who got linked. And i'm glad they've now been de linked and it's very clear that we can move forward with a bipartisan bill. That's broadly popular. Not just among members of congress but the american people npr congressional correspondent. Susan davis is with us to. Hey rachel so explain this backtrack by baton well. After biden made his comments. Republicans in the senate pushback really hard at this apparent veto threat suggesting he was pulling the rug out from them and that they could withdraw their support. For the bipartisan deal. The thing here is democrats for literally months. Have been talking about this to track. Approach doing the bipartisan infrastructure. Package and then moving along separately on their own on a reconciliation bill using budget rules. That wouldn't require republican support. Republicans including portman have acknowledged. The democrats could use that strategy and that is still the plan. It's just the threat that if they were not sent to the white house simultaneously. That's been walked back but the angle hasn't really changed. Okay so it's more about timing than anything else. Democrats what are they saying at this point the kind of unity that they need to get this bill through congress just the infrastructure bill. Yeah i mean as senate majority leader chuck schumer said last week. They can't pass one without the other. I think that's still true. Progressive democrats are only. Going to support the bipartisan deal. If they believe they have the votes to pass the separates reconciliation bill full of their priorities. This is why the speaker nancy pelosi is indicated. She could wait on the senate to prove they can pass a budget resolution before the house moves forward on any of this legislation so the fate of the two bills really remains connected it's gonna dominate the month of july in both the house and senate and likely well into the fall. And that's a big point of caution here. This is not going to happen fast. Democrats are going to have to try to pass a budget resolution in july that it's going to outline what they want to do with the separate legislation but it's a two step process and they're not gonna rate the actual bill likely until the fall so sue. You reported on this before but remind us what is in the second bill. The democrats separate stimulus package mean. Democrats have outlined a wishlist of what they'd like to see. I mean they're looking at trillions of dollars in spending that would expand the social safety net for programs like medicare they also want money for child care programs community college elder care climate change. Even some democrats have talked about wanting to put immigration reform legislation in. They're the two big questions rachel. We don't know the answers to yet. How much is it going to cost. And how are they going to pay for it Senate budget chairman bernie. Sanders has said that they could go as high as six trillion dollars for this package. Moderate democrats like west. Virginia's joe mansion are unlikely to go for that level of spending They're also going to have to figure out what they want to do with the trump tax cuts and whether they're going to roll back portions of it on the wealthy and big corporations to pay for it. This is about as complicated as it gets. It's going to take months for democrats to be able to figure out if they can get this through congress all right. Npr congressional correspondent. Susan davis appreciate you. Thanks nukem okay. Scientists are reporting another big advancement using the revolutionary gene. Editing technique called crisper to treat diseases yet for the first time doctors have infused crisper into the bloodstream of patients to try to help them and it appears to be working. Npr health correspondent rob steiner's with mourning. Rachel so this is good news. You have been reporting for a while. Now that crisper is leading scientists rewrite the genetic code much more easily than ever before and is already being tested to try to treat diseases so explain the newness of this moment yes. Doctors already helping patients with blood. Disorders like sickle cell disease in beta and it started trying to help patients with a variety of forms of cancer and even restore vision to people blinded by a rare genetic disorder but those experiments scientists are taking sells out of the body. Editing them in the lab and then back into patients or injecting directly to cells. It needs fixing. This is the first time they've just infused the crisper into patients bloodstreams and let it travel through the body of finding the right gene in the right place. So you know it's a big advance. That is amazing. So which disease did they try this for. it's called amyloidosis. It's a rare. Devastating disease passed. Down in families deformed protein damage is vital shoes and organs like the heart. I talked about this with patrick doherty. He's sixty five and lives in county donegal ireland he suddenly developed pins and needles in his hands and feet. Then we started getting short of breath just trying to walk dog. I'm tina skin breathless going up a small el-sayed here in donegal which which are many so i. I realized something was something was wrong. Something was wrong so you know. He volunteered for study testing. Crisper try to use it this new way. Okay so you said that this is about putting it directly into the patient's body gives us more details on how this works. It's really cool. Stockers infused billions of. microscopic structures. Not nanoparticles into doherty and five other volunteers. Each nanoparticle the genetic code for the chris grew. Gene editor the nanoparticles. They made their way to the liver. And unleashed an army of these crisper. Gene editors which honed in on the target gene to turn it off and within weeks already says he started feeling better as the levels of the bad protein causing the disease just plummeted so could this work for other diseases rep. Yeah this provides the first good evidence that crisper could be used like this many other much more common diseases for which taking sells out of the body or directly. Injecting them into patients isn't realistic. Like heart disease muscular dystrophy maybe even brain disorders like alzheimers. France bar is thrilled. He's back at work and looking forward to the future. I definitely an improvement in terms of mobility. My my my heart. My moving and walking again do fifteen fifteen thousand twenty thousand steps. We can go up again. He'll walk in with a dog. Good news for him in. Health correspondent rob steiner. Thank you you beverage and that is up first for this monday. June twenty eighth. I'm rachel martin. And i'm new king. We'd love it if you join us again tomorrow. In the meantime you can find us on twitter at up. First we appreciate the to listen to up. I really do. You can find more in depth coverage of the stories that we talked about today and a whole lot more on. Npr's morning edition. It is a radio show. it is awesome. Noel hosts it. I host it and we do so with steve inskeep. You can find morning edition.
Traveling in Ireland
"county donegal" Discussed on Traveling in Ireland
"Ashford castle always Ranking high in any any customer service or you know best hotels lists and that's in mayo and then there's the tranquil escape of lock s castle up in county donegal as far as castles go. It's very affordable five star absolutely beautiful and in one of my favorite counties in the country number to try a hawk falconi. falconry was the sport of kings. It's an experience that you aren't able to really enjoy in very many places and there is really nothing. Like standing there with your arm outstretched and watching this hawk just zero in on you as it comes in and just lands so lightly on your gloved wrist. It's the most amazing thing. My favorite falconry experience is with dare country pursuits at deir manner. That's in limerick. We've also had terrific experiences at falcons and westport house. Those are in mayo. They actually. it's the same. The same gentleman is in charge of both of those and he does a great job and then ashford castle also has a terrific hawk experience and then finally if you can afford it a driver. Guide is absolutely amazing. I am all about the self guided self drive tours but if you can afford a driver guide even if it's only for a day and maybe someplace that's incredibly scenic like the ring of kerry. It is so worth at the knowledge that a really great driver guide has coupled with the fact that you're not doing the driving and they have a luxury vehicle with big windows and you can just see everything and you're not having to worry about navigation. It is so so nice. I use an recommend show for travel. They are my preferred driver guide company. They're the company that i use for my guided tours and i highly highly recommend them. You can learn more about ireland. Show chauffeur travel as well as get my exclusive discount in shouts and i also have a free ireland vacation budgeting spreadsheets..
Travel WITH Stephanie Abrams!
"county donegal" Discussed on Travel WITH Stephanie Abrams!
"Want to describe the castle. You can't do a much better job. I don't you. Will you know her. So many years i heard about it and it it's in legends and stories to everyone's heard of it. It was just such an extraordinary experience to be there. you know. well it's not the kind of castle like a cinderella fairy tale castles. You'll find all over ireland. It's one of those square. Norman towers and with practically no windows and they were built by the normans as fortresses to be able to keep a stave off any invaders that might want to take over. And so you go inside and And you guys went walked ahead. It's about a good block that you walk on the grassy state And you can even go right into the castle or left into their gardens and We stayed behind for about a half hour with the fellow from that work there and when we were done we packed up our recording equipment and we were walking along and just as we got to the castle. The two of you came out and sister. Catherine was holding a brown paper bag hands like nine by twelve inch paper bag waving in the air saying i kissed the blarney stone i kissed the blarney stone so you were there. Can you explain what happened between. I'm not kissing the blarney stone. And i kissed the blarney stone. I i think she got I think she realized i have to do it. I have to do. i must do it. I'm in ireland. i've probably won't be back. This is i can't return from ireland and say no. I didn't kiss it sh- and she we just quitely talk to her and then she said well i'll try it and when she finished she was walking on air. As you said. I and i remember pulling that out and showing it to you i just line is shown i kissed the blarney stone and i understand that. She had two things as i recall. She got to see other people doing it and she saw this could be done without without losing your modesty with somebody looking up your skirt and she also got great encouragement and instruction from fellow. That worked there. Who you know you. Just don't go up and kiss it and walk away. There's somebody there that assist in that process. And i'm sure that guy has had busloads of nuns before by so he was quite conversant. I dunno it just reminds me of the taxi driver in washington. Dc the ever do a trade show or stand at an exhibit at a fair explaining things to somebody. If you stay in long enough at the table or booth of your where you're supposed to be the lower part of your back but comes a completely numb band about six inches wide across the whole of your back. Everyone in my audience that's ever done. A trade show knows exactly what i'm talking about and i was in washington. Dc doing show with the international franchise association. And we just left the show and i felt paralyzed literally. The my lower back was killing me and we called the taxi. You stopped and i went to get in and there was no way i was getting in the taxi. So anybody's ever experienced back. Pain knows getting in and out of a car is There's a technique and a talent for it. But i didn't know what it was because this never happened to me before and the taxi driver showed me what to do so while we're on that subject if it ever happens to you turnaround as so that. Your back is facing the seats in the car. Then bend your knees until your head bend your knees bend your head bump it your head will clear the doorway and then just push yourself backwards and you're in and then we drove to A pharmacy and got me pills to relief of pain but it was a taxi driver from all his experience when people with back pain. Who are traveling Who taught me how to do this. And it was the fellow at the top of pointy castle at all his experience who is able to instruct sister catherine out to safely and modestly kissed the blarney stone and she was so proud and was so happy to have a photo of it to take home. I mean that was hot. Yes she was yes she was and she still has that in her room house home. Very sweet i remember. We all had a good laugh about that. Not at not at her expense. Never i never knew she had to do it. We know about that until it turned around and she actually did it. That was the only negative commentary that came from sister catherine that entire trip. I mean you wanna talk the most positive just optimistic. Wonderful wonderful woman. I hope when you do speak with her you give her very best. Where did take a quick break. I'll be right back We've had katherine jarvis kathleen jarvis talking with us about her trip to ireland and when we do come back i want you to be thinking about places in ireland that you think my audience or put on their list of must visit places And maybe we could talk about knock shrine a bit more because I don't think many people even think about knock shrine and that's part of ireland. That whole galway mayo. Donegal stretch is exquisite. It's my favourite part of ireland. So we and you know what a tough stretch. It is for me to come up with favorite parts. But when i buy my castle by the sea and my we cottage by the sea in ireland they will be either in clare county clare county. Galway county mayo or county donegal. That whole stretch is.
Travel WITH Stephanie Abrams!
"county donegal" Discussed on Travel WITH Stephanie Abrams!
"Abrams Kathleen on that trip and trips you've taken since then to ireland and one you took when in the nineteen sixties a teenager The have favorite places in ireland. That stand out. Oh my gosh. i'm in love with ireland and in nineteen sixty. Six is a high school kid. I went with a friend and her mother to the aaron islands. And that's the only place we went. Her mom was an artist. We we spent a week there and she painted and we went to the sessions. I think they're called at night. There was no electricity and we just listened to irish music and it was it was it. I fell in love with ireland. Then and then a few years ago i took another sister to to another part of ireland and that was in donegal county donegal and To visit her where her ancestors came from her. Grandmother's family. Chris law and That way up in the northern part of ireland northern ireland but in the northern part of the republican ireland. Well what's funny about that. Is people in the republic put their noses in the air when anyone refers to northern ireland and the south because the republic of ireland while most of it is south of northern ireland which logically make some sense the most northern points on the island that are that is ireland are in donnie. Go which is part of the republic so when you go into donegal you've got this big square lake county kind of looks like a square rectangle and then coming off the top. The most northern part of county donegal is the rest of the county donegal which is like a peninsula that goes northward and eastward and wraps around the top of northern ireland so maidenhead the most northern point on the island that is ireland is not in northern ireland. it's in donegal in the republic and that peninsula. that comes off of donegal. while it's very much part of county donegal. They is referred to as into showing. And if you know the plays of martin mcdonagh the fellow that did the screenplay that won the academy award for three billboards in. I think it's eddington missouri or something like that He's his family is from there originally although he grew up in london and he writes a lot of plays about inishmore and inishmaan. And it's all referencing that In a show in peninsula area. It's very cool so Whether there any other things you wanted to mention that people could put down on there. I must see that to list. Oh well donegal absolutely erin. Islands absolutely We also visited Eden county In county kildare bolton abbey of course sister rosalie. Who paid with me on that trip. In two thousand seventeen is a benedictine sister from saint scope and she has a friend. At bolton abbey practice place in county county kildare said and that was supposed to be a one hour trip from dublin. Airport right for me driving on the left hand side first time in my life. It turned out to be a three hour trip. My hands off new wonderful has been marked how he got us around two thousand eight. Oliver ireland lawless played. A good news was it was september. You should be with us. When it's january or february and you get to the higher elevations up in the mountains. And there's snow and ice on the road on those whitey twisty roads then you have to complementary skills. I wanna thank you for joining us. Today it's been a pleasure having you with us and to everybody else we're flying. I its travel with stephanie. Abrams the live from fort smith. Arkansas is kathleen. A recipient of a stephanie. Abrams travel fairy godmother trip that she acted as the travel companion and good friend of sister. Catherine marquis from saint scholastica monastery in fort smith arkansas. Who wanted to get to ireland before her eightieth birthday literally the trip was in september of two thousand eight and when that trip ended Sister catherine had birthday almost immediately. I i mentioned something in the last segment of about going up steps into the library I don't think you go up steps. I think going on the main level and you're looking up at a catwalk walkway. That's way up there. But you're i think you're on the main level. It's been since i was inside but it's an amazing experience and of course it's a trinity college is A thriving college campus. And you feel the energy of that and the students in the heart of dublin A great area of dublin. Where there's so much going on you walk out the grounds of trinity college and you'll find a place called the irish whiskey museum. And it's not like the other tasting experiences and informational experience at tullamore. Who makes more do. And the d. e. w. is for the name of the guy who was his initials of the guy that may that may tell them more. Do may tell them. More whiskey famous. It's not like going to a bushmills jamison or There are a number of feelings in dublin also Because each of those is promoting their own brand really and their own history. The irish history of the irish whiskey museum covers about. I don't know a thousand or ten thousand years. I think it's a thousand years of irish whiskey history just as the development of the product and at the end they don't you know they they have whiskey tasting of all kinds of places and you can go slurp to your heart's content But something. I pay us on by the way because i don't drink but i so enjoyed that experience and then whole area call temple bar make sure you go Down fleet street and walk from the main street down. Fleet street to the river liffey That's an experience generally when you see promotions for ireland you will in the video. There's a spot where you see all these people in the street. And they're all walking in.