18 Burst results for "Coagulation Disorders"

"coagulation disorders" Discussed on Core IM | Internal Medicine Podcast

Core IM | Internal Medicine Podcast

06:44 min | Last week

"coagulation disorders" Discussed on Core IM | Internal Medicine Podcast

"So his next set of questions was actually focused on making sure. The patient was okay. He wanted to know about vital signs. Ortho statics hemoglobin. After that he started exploring the other categories in his scheme he asks for the platelet count and the complete haemogram as you recall she was anemic but play. The cat normal then again doesn't sound to me like a platelet disorder. Because it's it's a late in referring while the men arrages meno medoro asia. I think is typical of von wilburns disease since late and recurrent leading in that makes me think more of a bleeding disorder or a local saw tissue disorder instead of looking down the unwilling brain syndrome. Pathway again if she did have a pathology. I would call. I would look there to see. Is there something else there right. That's left behind But i can't do that then. I think Since then i think. I'm going to start doing acid coagulation. Assays just point out quickly. This is the second time that he's emphasize the delayed onset and the recurrent nature of this patients bleeding. It's a critical clue that the problem lies. Not in the formation of the platelet. Plug i e primary hema stasis that would cause immediate bleeding again. He's already suspicious. I soft tissue disorder. But with analogy report pending. He plays along and he starts to order coagulation studies. There's some simple testing metareum. That can be helpful right in terms of thinking about bleeding If if i want to do my deductive method and we have our pro-trump and time and are partial trauma classes time respectively. Both of them can be helpful in thinking about the common final pathway of coagulation cascade and the the program in time for the extrinsic seven factor seven seven and and the pt for intrinsic. Which i think are Eight nine eleven nine eleven twelve plus the common pathway so what is their. Pg which this laboratory okay. Pg twenty three point nine again laboratories so these being normal. It doesn't totally rule out coagulation disorder. But it makes it less likely that it is something to do with next intrinsic pathway. It could be factor. One receptor to If it was a vitamin k deficiency although that can affect factor which it also affects factor. Seven and nine and ten might even k. deficiency generally doesn't occur with now just malnutrition usually malnourished and on his office. Speaking of which she is her diet. Okay cindy the way. He explicitly talked about the factors. Here kind of stuck with me. He could have just asked for the p. T. npt instead. He runs through the factors that contribute to each before asking for the result as lhasa surprising. I mean that's the way it was taught in medical school. No i'm not saying it's arcane knowledge. I mean yes. I also remember the factors from med school. Maybe maybe with some effort. I don't. i'm sure you could recall them with effort. And but to be honest somewhere in the ten years between when we learned the cascade and today my brain just decided to stop carrying about which factors were part of what pathway and justified this by saying that in the real world as a general internist being able to see an isolated pt prolongation for example. And just recognize. Okay that's an extrinsic. Pathway problem i should think about war friend vitamin k deficiency liver disease so most of that time that abridged model of pathophysiology. That is good enough in daily practice. You're seeing it's almost like there's a level pathophysiology that's now worth remembering. Once i entered a clinical world certain things. Just don't apply in real life anymore. I mean don't tell my medical students. I said that but yeah basically Feel like pathophysiology is kind of like an ocean. I could dive deeper and deeper but beyond a certain depth. It's just too dark uncertain and cold and style. I drown so that's why i was surprised that are discussing. Has the factors the regulation factors in his working memory. He retrieves those details with such ease. And there's a part of me that wondered like why does he bother to remember that. Should i bother number that. Isn't it distracting. This became a recurring theme during our interview over and over again doctor. Osman would get very granular in his discussion of pathophysiology. And while cindy and. I certainly entertained the possibility that this was just because his teaching mode was engaged. He has a reputation within our group. For just having prodigious prodigious knowledge it honestly it felt like more than that it felt like these asides were in fact part of his diagnostic process. It wouldn't be. It's less likely to be. i think. Type one von will of rand's where you get factor eight but acquired von will brands disease with like a Whether it's from a high flow state or a like a white a arctic para valvular league or a mile plastics syndrome. They often have. They will have a normal willow brand factor level. Normal wrist ascendancy tests. I don't really remember exactly the details of that and it will have normal factory pt. But they're losing their large grant factor multiple errors. That are the most important ones in terms of of clotting. That's something i would think about So so Did she get an evaluation for that. Just to remind you of those results remember both the quantitative and qualitative on willow branch factor assays. Were normal as was the factor eight activity essay. So it makes it less likely but it's not sensitive at all for certain conditions and the problem is the diagnosis is made by this vonleh brandon. Molterer say that is usually not done in most hospitals in his operator dependence. I would you know if i think she has acquired. Von wilburns is one good reason. Why right so. I'm still looking..

meno medoro brain syndrome metareum coagulation disorder vitamin k deficiency liver dis cindy asia med school lhasa Osman vonleh brandon Molterer Von wilburns
"coagulation disorders" Discussed on New Jersey 101.5

New Jersey 101.5

01:42 min | 2 months ago

"coagulation disorders" Discussed on New Jersey 101.5

"From new chairs these most to listen to station, New Jersey one A 1.5 news starts Now It's seven o'clock. I'm Chan Robinson topping our report this hour. If you're just joining us, the government is expected to collect more tax revenue than had been forecast this spring. No final details won't be ready until the second week of June. David Drescher of the Office of Legislative Services says the sales tax has been a consistent bright spot and that realty transfer fees are far above expectations. Most of the revenues that we track other than those are performing roughly in line with expectations, But our initial outlook is that our revised forecast in a few weeks. Will increase notably, he says. It's too soon to draw conclusions about income taxes or corporate business taxes and the first reported case of its kind, healthy 85 year old man developed a rare recurrence of deep blood clots in his arm as a result of covert 19 this, according to Rutgers researchers and reported by the Esprit parked press. Researchers say the virus can also trigger coagulation disorders, especially cloths. How would how will Jersey shore businesses fare during this second summer of Cove? It that all depends on you and stay two of our summer at the shore. Syriza's so far, merchants are liking what they see compared to 2020. Aileen Crowley, Fee hand general manager of the Funhouse stores, and Asbury Park, says they're steadily getting busier. The weekends have been crazy. We anticipate a very, very busy some lucky. Leo's owner, Steve Whelan, says his arcade on the seaside heights Boardwalk will likely double last summer's business..

David Drescher Aileen Crowley Steve Whelan Chan Robinson Rutgers 2020 seven o'clock Asbury Park New Jersey Office of Legislative Services Funhouse Jersey two second week of June Cove 85 year old this spring double Esprit last summer
"coagulation disorders" Discussed on WBEZ Chicago

WBEZ Chicago

07:45 min | 3 months ago

"coagulation disorders" Discussed on WBEZ Chicago

"It's not only a reflection off the Trumbo's is, it's not only a reflection off the clouds But it's a reflection off the coagulation activation and the consumption off all the coagulation factors. And so this leads to dis massive increase in the diamond levers. E mean, what's interesting to me the sort of clinical markers that you look for when you have a patient, and they sort of confirmed that there's a problem. A supposed disinterest music. It sounds to me. They don't tell you what's caused the problem. And I know that in this instance you could use collaborated with German scientists who Be looking at samples from other patients as well and you're trying to build up a picture. Yes, that's true because there is only a couple off off diseases off disorders. Which we know off, which might cost his combination off Trump aside to Pina and Trumbo, seas and many off those were quickly excluded. And then what remained was heparin induced trump aside a pina But the patient did not receive heparin before the symptoms started on heparin. It's a blood thinner that sometimes yes, heparin is it's a black Xena. It's usually used for treating offer preventing trump pulses. But the patient did not receive heparin and Neither did the other patients. I knew that even if it is not heparin juice Trump aside Dapena the combination off stimulation off the immune system by the vaccine. Together with Trump aside to Pina and Trumbo's is for me indicated involvement off platelets involvement off highly activated platelets. Which leads to the Trumbo's is because this is them The common phenomenon in all these disorders. The platelets in this process get highly activated by this immune reaction. See if we could just don't pick this a little. Then take a step back. First of all the idea off vaccines. Being associated with this kind of blood clotting until this year was not known about is not is not being ever reported before. Is that right? Yes. This was not known about not okay s so if there is a connection, it must be something specific about this vaccine. That you have to be looking for the AstraZeneca vaccine uses an adenovirus. And the adenovirus itself does not cause any harm for human beings. Yes, it could, of course, be the specific a dental virus in combination with despite protein. It could be something which is in the vaccination fluid. It could be something which is created during the protection off the vaccine. It could be the inflammation process, which is induced by the vaccine. And this is something which is also different from patient to patient, So this is also something we were. We are thinking about, so there are different possibilities because it's the one of the UK experts said at the press conference on Wednesday. If it's understood what the problem is in, the hope would be that's even this small risk off. These blood clots could also be eradicated because you could make the appropriate changes. That's pretty important to try and Get to the bottom of this. Yes, This is of course, off at most importance. It is important to really and remember what this whole process is about. What it what induces this process. What is it that induces this antibody production not against the coronavirus only, but also against Other structures, which then causes Trumbo's is, Of course, the Emma and the UK Medical Health Regulations Agency have both said that the vaccine should still be used. And in general, the benefits outweigh the risk of these clots. But knowing what you do from Your own observations and studies. If patients do get this clotting Do you think there are ways they can be saved? Yes, Yes, This is a kiss. This cannot be stressed enough because first of all, it's a really rare disorder. Second, it can be Very well treated. If you realize it if you detected early, if you know what you have to look for. Then you can detect the drum poses early and you also can't can detect the coagulation disorder early and then you can treat the patient very specifically. And then the disease goes away and the patient will be fine. Sabina I finger whose investigations were posted as a pre print on research square last week. You wait 10 years for an interesting result in fundamental physics. My next guest there to me and then to come along in just two weeks. Perhaps it's a new law of science. Cambridge University's Harry Cliff was talking to us just a couple of programs back about intriguing observations that had just come in from his son. Experiment. Alex CIB results concerning the behavior of so called B or beauty, quartz. And new ones, ephemeral objects that belong to the subatomic particle zoo results, though, that give a clue to what lies beyond our current understanding of their physics. Any results concerning the slightly way with magnetism off the me on? Maybe another clue. They come from an experiment at Fermi Lab in the USA called G minus two. So we are sorry back to remind us first about those new ones. So anyone is a fundamental particle. It's kind of like a heavy version of the electron that you find inside every ordinary atoms. So it's about 200 times more massive than the electron and they're very unstable. So these things they live around. I think a millionth of a second, then they decay into electrons and neutrinos. So that's why they don't hang around very much of the world around us, although actually there are sort of dozens of the passing through you every second because they created In the upper atmosphere when cosmic rays bang into the earth, so they're actually all around us. We're just not really aware of them, but they don't form sort of stable matter atoms in the way electrons do, which makes them hard to experiment on, But I guess that's also They shine a little bit, I suppose, in the process of decaying, which is what they've been looking at in these experiments at Fermilab, Yes. What family? What they do is they create a beam of new ones, and they put it into what they call a storage ring, which this big, big sort of metal ring essentially and they go around that ring pretty close to the speed of light. That means they can hold onto these Mulan's a bit longer than you would be able to if they were just sitting sitting still now what they were trying to measure. Let's let me if I can break this down. If you could give me some, yes. No, roughly correct sort of our officers. These new ones. In one sense, they behave a bit like little subatomic spinning tops. Yeah, That's right. Well, they have this property called spin, which a lot all the matter. Particles actually do electrons have spent as well which you can kind of picture as if they're spinning tops. But that's kind of wrong because it's there is Consummated. It's our best game. Wait is this property is quantum mechanical? So I mean, sort of the mental picture breaks down at some point, but for the sake of argument, yet it's a bit like a spinning top week was like if I like you, but at the same time, they also behave like people. Magnets. Yeah, exactly. So if you have a sort of a moving charge, Yeah, Lord in ordinary life, you have sort of a coil of wire with electric charge running around it that creates a magnetic fields. If you think of the new one is this little sphere of charge, it's spinning..

Harry Cliff UK Medical Health Regulations 10 years USA Wednesday Sabina Trump Cambridge University Alex CIB two weeks last week Second trump both Fermi Lab Trumbo one sense G minus two UK AstraZeneca
"coagulation disorders" Discussed on WBEZ Chicago

WBEZ Chicago

07:17 min | 3 months ago

"coagulation disorders" Discussed on WBEZ Chicago

"Government officials in South Africa banned booze to keep people from gathering during the pandemic. We saw a dramatic drop in hospitalizations. But more specifically, we saw a dramatic drop in trauma related hospitalizations that opened more beds for covert 19 patients and new conversations about the country's complicated relationship with alcohol on the next morning edition from NPR news. That's this morning from 5 to 9 A.m. Here on 91.5 W be easy. BBC World Service as European medicine agencies confirmed a connection between the AstraZeneca vaccine and unusual blood clocks, so it's actually hears about one of the earliest cases. She had very, very low platelets and at the same moment, really Syria from biotic complications. So from that moment, I already knew that there is something very particular about this case. What are the details reveal about the causes of the clotting. Join me after the news. BBC News The North Korean leader Kim Jong UN, has warned of a difficult crisis ahead as human rights groups said the country faces dire food shortages on economic instability. Speaking at a party conference, Mr Kim appeared to compare the situation to a deadly famine in the 19 nineties. The country shut its borders last year due to the Corona virus pandemic. Tensions have escalated between China and the Philippines over disputed waters. On Thursday, the Chinese navy sent to fast attack craft to chase down a Filipino ship within the Philippines internationally recognized waters. It's the first recorded instance of Chinese military vessels being used against civilians since the latest dispute began several weeks ago. China says it will take steps to uphold the interests of its firms after Washington added seven Chinese supercomputing centers to a blacklist. The U. S Commerce Department said the centers were being used by the Chinese military. The listing was the first move by the Biden administration to prevent Beijing accessing sensitive technology. About 16,000 people on the eastern Caribbean island of ST Vincent have been ordered to leave their homes because of volcano is at risk of erupting that Soufriere volcano is spitting steam, and scientists say they can see magma moving towards its surface. People forced to flee will be given temporary homes on cruise ships and in safer parts of ST Vincent Thea Army in Nigeria says 11 soldiers have been killed in central Ben Way, state military spokesman said they were attacked while on routine operations. Armed gangs are present in the area. Person says it will allow Myanmar's ousted ambassador to stay in the country after being banned from his embassy in London Jaw was wired men opposed February's military takeover in Myanmar. He said a military attache had prevented him from re entering. The embassy BBC news. Welcome to science in action from the BBC World Service with me Roland Piece later in the program spinning new ones give a new twist to the theories of the stuff. We're made off the fact that you're seeing these anomalies and different experience completely different sorts of measurements, and they seem to be pointing in the same direction. I think that's why a lot of physicists could be getting quite excited. Today we hear from a fully trained spin, doctor. In a moment we've words even Maura made up than me on On. Do we learn the meaning of this? You're meant to be impressed. We start with what looks like confirmation that there is a very small but very real risk of blood clots related to the Oxford AstraZeneca Covad vaccine. This is the one using an adenovirus engineered to carry the SARS cov to spike protein and it's Jean. In a pair of press conferences on Wednesday, the European Medical Agency and its equivalent in the UK the M H. R a revealed in total 141 cases, 37 of them fatal Following doses given to 45 million people. The association is statistical but compelling. Connection Low is a mystery but important as Muneer Perma Hamid, chair off the commission on human Medicines, told the UK press conference. I think it is really important to understand the mechanisms because it might provide us with ways of being able to prevent this in the future. For example, If you were able to identify the mechanisms, you'll be able to refine the advice that's given so we can actually identify risk factors, for example, and then try to prevent it. Individuals who have those risk factors. It may also allow us to be able to then think about modified modified vaccines, which do not cause this particular adverse event in the future. You mentioned the ad. No viral vector. And yes, there are several vaccines with no viral vectors. But we don't know where they just related are Navarro Vector, which is related something else at the moment and again. That's part of the scientific work that he's trying to go to moment. Hematologist Sabina Eichinger, an expert on rare blood clots that Vienna Medical University has been involved in one close study into the mechanism. Having treated a vaccinated patient in her own hospital. Yes, it was unusual. From the first moment I saw her because the most striking thing from a medical point of view Watts. That this patient had to see We're coagulation disorder. So she very, very low platelets. And at the same moment she had really Syria from biotic complications and this on first side, you might think that one would exclude the other. So usually patients who have very, very low platelet counts. They do have a bleeding tendency, but those patients usually do not have from bosses. These patients had really, really low platelet counts and massive Trumbo's is so from that moment on, I already knew that there is something very particular about this case. Um, I presume in her patient history to included that she'd recently had the vaccine. Yes. Yes, she had the vaccine. She went to the hospital 10 days after, but her symptoms already started a couple of days earlier. And besides, we're measuring the platelets, which one of these factors that we have in our blood, So I think they're involved in clotting is the idea of them. Besides a low number of those, what kinds of measurements do you make? That might be a clue as to what's going on. Another important parameter would be the so called the diamond and the deed. I'm a It's usually elevated in patients who have Trumbo's is, But in these patients, the diamond is really, really Hi indeed, Diamonds. That kind of protein is I think it is some kind of bio marker that becomes elevated with inflammation is that it's also elevated with information did timer effect is very an specific, so a lot off this orders. Leads toe increased the diamond labors. It might be inflammation it might be Trump poses. It might be a coagulation disorder. And in these patients, the diamond is very elevated because the coagulation system is so activated..

37 Sabina Eichinger Wednesday European Medical Agency Thursday Vienna Medical University Trump Kim Jong February 141 cases BBC World Service Kim 11 soldiers London South Africa Nigeria U. S Commerce Department 19 patients Muneer Perma Hamid last year
"coagulation disorders" Discussed on NEWS 88.7

NEWS 88.7

06:58 min | 3 months ago

"coagulation disorders" Discussed on NEWS 88.7

"Yes, that's true because there is only a couple off off diseases off disorders. Between off, which might cost his combination off Trump aside to Pina and Trumbo, seas and many off those were quickly excluded. And then what remained was heparin induced trump aside to Pina. But the patient did not receive heparin before the symptoms started on heparin. It's a blood thinner that sometimes yes, Heparin is a blood thinner. It's usually used for treating offer preventing trump pulses. But the patient did not receive heparin and Neither did the other patients. I knew that even if it is no temper induced Trump aside, Dapena. The combination off stimulation off the immune system by the vaccine together with Trump aside to Pina. And Trumbo sees for me indicated involvement off platelets involvement off highly excavated platelets. Which leads to the Trumbo's is because this is them The common phenomenon in all these disorders. The platelets in this process get highly activated by this immune reaction. So if we could just don't pick this a little, then take a step back. First of all the idea off vaccines being associated with this kind of blood clotting. Until this year was not known about is not is not being ever reported before. Is that right? Yes. This was not known about not okay s so if there is a connection, it must be something specific about this vaccine. That you have to be looking for the AstraZeneca vaccine uses an adenovirus. And the adenovirus itself does not cause any harm for human beings. Yes, it could, of course, be the specific a dental virus in combination with despite protein. It could be something which is in the vaccination fluid. It could be something which is created during the protection off the vaccine. It could be the inflammation process, which is induced by the vaccine. And this is something which is also different from patient to patient, So this is also something we were. We are thinking about, so there are different possibilities because it's the one of the UK experts say that the press conference on Wednesday If it's understood what the problem is that the hope would be that's even this small risk off. These blood clots could also be eradicated because you could make the appropriate changes. That's pretty important to try and Get to the bottom of this. Yes, This is of course, off. At most important it is important to really under every what This whole process is about what it what induces this process. What is it that induces this antibody production not against the coronavirus only, but also against Other structures, which then causes Trumbo's is, Of course, the Emma and the UK Medical Health Regulations Agency have both said that the vaccine should still be used. And in general, the benefits outweigh the risk of these clots. But knowing what you do from Your own observations and studies. If patients do get this clotting do you think there are ways they can be saved? Yes, Yes, This is a kiss. This cannot be stressed enough because first of all, it's a really rare disorder. Second, it can be Very well treated. If you realize it if you detected early, if you know what you have to look for. Then you can detect the drum poses early and you also can't can detect the coagulation disorder early and then you can treat the patient very specifically. And then the disease goes away and the patient will be fine. Sabina. I concur, whose investigations were posted as a pre print on research square last week. You wait 10 years for an interesting result in fundamental physics. My next guest said to me and then to come along in just two weeks. Perhaps it's a new law of science. Cambridge University's Harry Cliff was talking to us just a couple of programs back about intriguing observations that had just come in from his son. Experiment. Alex TB results concerning the behavior of so called B or beauty, quartz. And new ones, ephemeral objects that belong to these subatomic particle zoo results, though, that give a clue to what lies beyond our current understanding of their physics. Any results concerning the slightly wayward magnetism off the me on? Maybe another clue. They come from an experiment at Fermi Lab in the U. S A. Called G minus two. So we are sorry back to remind us first about those new ones. So, um, you want is a fundamental particle. It's kind of like a heavy version of the electron that you find inside every ordinary atoms. So it's about 200 times more massive than the electron and they're very unstable. So these things they live around thinking millionth of a second. Then they decay into electrons and neutrinos. So that's why they don't hang around very much of the world around us, although actually there are sort of dozens of the passing through you every second because they created The apparatus fear when cosmic rays bang into the earth, so they're actually all around us. We're just not really aware of them, but they don't form sort of stable matter atoms in the way electrons do, which makes them hard to experiment on, But I guess that's also They shine a little bit, I suppose, in the process of decaying, which is what they've been looking at in these experiments at Fermilab, Yes, what family? What they do is they create a beam of new ones, and they put it into what they call a storage ring, which this big, big sort of metal ring essentially and they go around that ring pretty close to the speed of light, And that means they can hold onto these Mulan's a bit longer than you would be able to if they were just sitting Sitting still now what they were trying to measure. Let's let me if I can break this down. If you could give me some, yes. No, roughly correct sort of our officers. These new ones. In one sense, they behave a bit like little subatomic spinning tops. Yeah, That's right. Well, they have this property called spin, which a lot all the matter. Particles actually do electrons have spent as well which you can kind of picture as if they're spinning tops. But that's kind of wrong because it's there is Consummated. It's our best girl wakes this property is quantum mechanical. So I mean, sort of the mental picture breaks down at some point, but for the sake of argument, yet it's a bit like a spinning top week because they like you, but At the same time, they also behave like little bar magnets. Yeah, exactly. So if you have a sort of a moving charge, Yeah, Lord in ordinary life, you have a sort of a coil of wire with electric charge running around it that creates a magnetic fields..

Wednesday Harry Cliff UK Medical Health Regulations 10 years Trump Sabina Cambridge University Fermi Lab last week two weeks Alex TB First Second Fermilab millionth of a second both trump Heparin about 200 times heparin
"coagulation disorders" Discussed on WBEZ Chicago

WBEZ Chicago

06:58 min | 3 months ago

"coagulation disorders" Discussed on WBEZ Chicago

"Yes, that's true because there is only a couple off off diseases off disorders. Which we know off, which might cost his combination off Trump aside to Pina and Trumbo, seas and many off those were quickly excluded. And then what remained was heparin induced trump aside to Pina. But the patient did not receive heparin before the symptoms started on heparin. It's a blood thinner that sometimes yes, Heparin is a blood thinner. It's usually used for treating offer preventing trump pulses. But the patient did not receive heparin and Neither did the other patients. But I knew that even if it is no tapering juice trump aside Dapena The combination off stimulation off the immune system by the vaccine together with Trump aside to Pina. And Trumbo sees for me indicated involvement off platelets involvement off highly activated platelets. Which leads to the Trumbo's is because this is them The common phenomenon in all these disorders. The platelets in this process get highly activated by this immune reaction. If we could just don't pick this a little, then take a step back. First of all the idea off vaccines being associated with this kind of blood clotting. Until this year was not known about is not is not being ever reported before. Is that right? Yes. This was not known about not okay s so if there is a connection, it must be something specific about this vaccine that you have to be looking for their AstraZeneca. Vaccine use isn't Adenovirus. And the adenovirus itself does not cause any harm for human beings. Yes, it could, of course, be the specific a dental virus in combination with despite protein. It could be something which is in the vaccination fluid. It could be something which is created during the protection off the vaccine. It could be the inflammation process, which is induced by the vaccine, and this is something which is also different from patient to patient. So this is also something we were. We are thinking about. So there are different possibilities because it is the word of the UK experts say that the press conference on Wednesday if it's understood what the problem is that the hope would be that even this small risk. Off. These blood clots could also be eradicated because you could make the appropriate changes. That's pretty important to try and get to the bottom of this. Yes, This is of course, off at most importance. It is important to really under every what This whole process is about what it what induces this process. What is it that induces this antibody production not against the coronavirus only, but also against Other structures, which then causes Trumbo's is, Of course, the Emma and the UK Medical Health Regulations Agency have both said that the vaccine should still be used. And in general, the benefits outweigh the risk of these clots. But knowing what you do from Your own observations and studies. If patients do get this clotting Do you think there are ways they can be saved? Yes, Yes, This is a kiss. This cannot be stressed enough because first of all, it's a really rare disorder. Second, it can be Very well treated. If you realize it if you detected early, if you know what you have to look for. Then you can detect the drum poses early and you also contact can detect the coagulation disorder early and then you can treat the patient very specifically. And then the disease goes away and the patient will be fine. Sabina I finger whose investigations were posted as a pre print on research square last week. You wait 10 years for an interesting result in fundamental physics. My next guest there to me and then to come along in just two weeks. Perhaps it's a new law of science. Cambridge University's Harry Cliff was talking to us just a couple of programs back about intriguing observations that had just come in from his son. Experiment. Alex CIB results concerning the behavior of so called B or beauty, quartz. And new ones, ephemeral objects that belong to the subatomic particle zoo results, though, that give a clue to what lies beyond our current understanding of their physics. Any results concerning the slightly way with magnetism off the me on? Maybe another clue. They come from an experiment at Fermi Lab in the USA called G minus two. So we are sorry back to remind us first about those new ones. So, um, you want is a fundamental particle. It's kind of like a heavy version of the electron that you find inside every ordinary atoms. So it's about 200 times more massive than the electron and they're very unstable. So these things they live around. I think a millionth of a second. Then they decay into electrons and neutrinos. So that's why they don't hang around very much of the world around us, although actually there are sort of dozens of the passing through you every second because they created In the upper atmosphere when cosmic rays bang into the earth, so they're actually all around us. We're just not really aware of them, but they don't form sort of stable matter atoms in the way electrons do, which makes them hard to experiment on, But I guess that's also They shine a little bit, I suppose, in the process of decaying, which is what they've been looking at in these experiments at Fermilab, Yes. What family? What they do is they create a beam of new ones, and they put it into what they call a storage ring, which this big, big sort of metal ring essentially and they go around that ring pretty close to the speed of light. That means they can hold onto these Mulan's a bit longer than you would be able to if they were just sitting sitting still now what they were trying to measure. Let's let me if I can break this down. If you could give me some, yes. No, roughly correct sort of our officers. These new ones. In one sense, they behave a bit like little subatomic spinning tops. Yeah, That's right. Well, they have this property called spin, which a lot all the matter. Particles actually do electrons have spent as well which you can kind of picture as if they're spinning tops. But that's kind of wrong because it's Is Consummated. It's our best game. Wait is this property is quantum mechanical? So I mean, sort of the mental picture breaks down at some point, but for the sake of argument, yet it's a bit like a spinning top week because, like you, I like you, but at the same time, they also behave like little bar magnets. Yeah, exactly. So if you have a sort of a moving charge, Yeah, Lord in ordinary life, you have a sort of a coil of wire with electric charge running around it that creates a magnetic fields..

10 years Harry Cliff Wednesday Sabina UK Medical Health Regulations USA Trump Cambridge University last week Fermi Lab two weeks Fermilab Second Alex CIB First both Emma G minus two earth about 200 times
"coagulation disorders" Discussed on NEWS 88.7

NEWS 88.7

07:40 min | 3 months ago

"coagulation disorders" Discussed on NEWS 88.7

"Future. BBC World Service as European medicine agencies confirmed a connection between the AstraZeneca vaccine and unusual blood clots. So it's actually hears about one of the earliest cases she very, very low platelets and at the same moment, really Syria Trump Arctic complications. So from that moment, I already knew that there is something very particular about this case. What are the details reveal about the causes of the cottage on me after the news? Vizzini is with Chris Barrow. President Bindon has unveiled his first attempts to control gun violence in the United States, which he called an epidemic and an international embarrassment. The measures include a crackdown on ghost guns, which can be assembled at home on bolstering background checks. Correspondents say the legislation would almost certainly be blocked by Republicans. Within hours of President Biden's announcement on gun curves. A man was killed in a shooting in the U. S State of Texas. A number of people were also wounded, including a state trooper. The suspect was later arrested. A senior official in Russia has said that Moscow could intervene to help its citizens in eastern Ukraine as tensions rise in the region. The warning comes after weeks of increased fighting in the region between Ukrainian forces and Russian backed rebels. The U. S defense official says Washington is considering sending warships into the Black Sea. Brazil has reported a new daily record number of deaths caused by the Corona virus and the delays in the vaccination program and the collapse of the public health system in many regions. More than 4200. People have died of Cove it in the past 24 hours. Protesters in Northern Ireland's have clashed with police. During another night of violence. A crowd of writers threw petrol bombs, fireworks and stones at police officers used water cannon for the first time in six years. Protesters are angered by a number of factors, including the impact of Brexit on northern islands. A team of international scientists have begun a study on how the corona virus pandemic has drastically reduced ocean sound pollution. The researchers say they hope to learn how human noise impacts marine life. The project will analyze data from underwater microphones to see which see habitats could benefit from a continued slowdown in global shipping. BBC news. Welcome to science in action from the BBC World Service with me Roland Piece later in the program spinning New Orleans give a new twist to the theories of the stuff. We're made off the fact that You're seeing these anomalies and different experience completely different sorts of measurements, and they seem to be pointing in the same direction. I think that's why a lot of physicists could be getting quite excited. Today we hear from a fully drained spin, doctor. In a moment we've words even Maura made up than me on And we learn the meaning of this. You're meant to be impressed. We start with what looks like confirmation that there is a very small but very real risk of blood clots related to the Oxford AstraZeneca Covad vaccine. This is the one using an adenovirus engineered to carry the SARS cov to spike protein and it's Jean. In a pair of press conferences on Wednesday, the European Medical Agency and its equivalent in the UK the M H. R a revealed in total 141 cases, 37 of them fatal Following doses given to 45 million people. The association is statistical But compelling. The connection low is a mystery, but important as Muneer Perma Hamid, chair off the commission on human Medicines, told the UK press conference. I think it is really important to understand the mechanisms because it might provide us with ways of being able to prevent this in the future. For example, if you were able to identify the mechanisms, you'll be able to refine the advice that's given so we can actually identify risk factors, for example, and then try to prevent it. Individuals who have those risk factors. It may also allow us to be able to then think about modified modified vaccines, which do not cause this particular adverse event in the future. You mentioned the ad. No viral vector. And yes, there are several vaccines with no viral vectors. But we don't know where they just related at Navarro Vector, which is related something else at the moment and again. That's part of the scientific work that destroying the god moment. Hematologist Sabina Eichinger, expert on rare blood clots at Vienna Medical University, has been involved in one close study into the mechanism. Having treated a vaccinated patient in her own hospital. Yes, it was unusual. From the first moment I saw her because the most striking thing from a medical point of view Watts. That this patient had see we're coagulation disorder. So she very, very low platelets, and at the same moment she had really Syria from barking complications and this on first side, you might think that one would exclude the other. So usually patients who have very, very low platelet counts. They do have a bleeding tendency. It's those patients usually do not have Trumbo's is, but these patients had really, really low platelet counts and massive Trumbo's is so from that moment on. I already knew that there is something very particular about this case. My presuming her patient history to included that she'd recently had the vaccine. Yes, Yes, she had the vaccine. She went to the hospital 10 days after, but her symptoms already started a couple of days earlier. And besides, we're measuring the platelets, which one of these factors that we have in our blood, So I think they're involved in clotting is the idea of them. Besides a low number of those, what kinds of measurements do you make? That might be a clue as to what's going on. Another important parameter would be the so called the diamond and the deed. I'm a is usually elevated in patients who have Trumbo's is, But in these patients, the diamond is really, really Hi Andy Diamonds That kind of protein is I think it is some kind of bio marker that becomes elevated with inflammation is that it's also elevated with information did time effect is very an specific, So a lot off this orders. Leads toe increased the diamond levers. It might be inflammation it might be Trump poses, it might be a coagulation disorder. And in these patients that the timing is very elevated because the coagulation system is so activated. It's not only a reflection off the Trumbo's is it's not only a reflection off the clouds, but it's a reflection off the coagulation activation and the consumption off order coagulation factors. And so this leads to this massive increase in the diamond levers. I mean, what's interesting to me these air sort of clinical markers that you look for. When you have a patient, and they sort of confirmed that there's a problem, I suppose. What's interesting is it sounds to me. They don't tell you what's caused the problem. And I know that in this instance you could use collaborated with German scientists who who Being looking at samples from other patients as well and you're trying to build up a picture. Yes, that's true because there is only a couple off off diseases off disorders. Between off, which might cost his.

Sabina Eichinger Chris Barrow United States 37 141 cases Wednesday BBC World Service European Medical Agency Northern Ireland Muneer Perma Hamid Today Roland Piece six years Black Sea Maura New Orleans UK AstraZeneca Republicans Brexit
"coagulation disorders" Discussed on WBEZ Chicago

WBEZ Chicago

07:38 min | 3 months ago

"coagulation disorders" Discussed on WBEZ Chicago

"BBC World Service as European medicine agencies confirmed a connection between the AstraZeneca vaccine and unusual blood clocks, so it's actually hears about one of the earliest cases. She had very, very low platelets and at the same moment, really Syria from barking complications. So from that moment, I already knew that there is something very particular about this case. What are the details reveal about the causes of the cottage on me after the news? BBC Knees with Chris Barrow. President Bindon has unveiled his first attempts to control gun violence in the United States, which he called an epidemic and an international embarrassment. The measures include a crackdown on ghost guns, which can be assembled at home and bolstering background checks. Correspondents say the legislation would almost certainly be blocked by Republicans. Within hours of President Biden's announcement on gun curves. A man was killed in a shooting in the U. S State of Texas. A number of people were also wounded, including a state trooper. The suspect was later arrested. A senior official in Russia has said that Moscow could intervene to help its citizens in eastern Ukraine as tensions rise in the region. The warning comes after weeks of increased fighting in the region between Ukrainian forces and Russian backed rebels. The U. S defense official says Washington is considering sending warships into the Black Sea. Brazil has reported a new daily record number of deaths caused by the Corona virus and the delays in the vaccination program and the collapse of the public health system in many regions. More than 4200. People have died of Cove it in the past 24 hours. Protesters in Northern Ireland's have clashed with police. During another night of violence. A crowd of writers threw petrol bombs, fireworks and stones at police officers used water cannon for the first time in six years. Protesters are angered by a number of factors, including the impact of Brexit on Northern Ireland's A team of international scientists have begun a study on how the corona virus pandemic has drastically reduced ocean sound pollution. Researchers say they hope to learn how human noise impacts marine life. The project will analyze data from underwater microphones to see which see habitats could benefit from a continued slowdown in global shipping. BBC news. Welcome to science in action from the BBC World Service with me Roland Piece later in the program spinning new ones give a new twist to the theories of the stuff. We're made off the fact that you're seeing these anomalies and different experience completely different sorts of measurements, and they seem to be pointing in the same direction. I think that's why a lot of physicists could be getting quite excited. Today we hear from a fully trained spin, doctor. In a moment we've words even Maura made up than me on On. Do we learn the meaning of this? You're meant to be impressed. We start with what looks like confirmation that there is a very small but very real risk of blood clots related to the Oxford AstraZeneca Covad vaccine. This is the one using an adenovirus engineered to carry the SARS cov to spike protein and it's Jean. In a pair of press conferences on Wednesday, the European Medical Agency and its equivalent in the UK the M H. R a revealed in total 141 cases, 37 of them fatal Following doses given to 45 million people. The association is statistical But compelling. The connection low is a mystery, but important as sermon ear Perm Hamid chair off the commission on human Medicines, told the UK press conference. I think it is really important to understand the mechanisms because it might provide us with ways of being able to prevent this in the future. For example, If you were able to identify the mechanisms, you'll be able to refine the advice that's given so we can actually identify risk factors, for example, and then try to prevent it. Individuals who have those risk factors. It may also allow us to be able to then think about modified modified vaccines, which do not cause this particular adverse event in the future. You mentioned the ad. No viral vector. And yes, there are several vaccines with no viral vectors. But we don't know where they just related at Navarro Vector, which is related something else at the moment and again. That's part of the scientific work that destroying the goat moment. Hematologist Sabina Eichinger, I'm expert on rare blood clots that Vienna Medical University has been involved in one close study into the mechanism. Having treated a vaccinated patient in her own hospital. Yes, it was unusual. From the first moment I saw her because the most striking thing from a medical point of view Watts. That this patient had to see We're coagulation disorder. So she very, very low platelets, and at the same moment she had really Syria from Baltic complications. And this on first sight. You might think that one would exclude the other So usually patients who have very, very low platelet counts. They do have a bleeding tendency. It's those patients usually do not have thrombosis. But these patients had really, really low platelet counts and massive Trumbo's is so from that moment on. I already knew that there is something very particular about this case. My presuming her patient history to included that she'd recently had the vaccine. Yes, Yes, she had the vaccine. She went to the hospital 10 days after, but her symptoms already started a couple of days earlier. And besides, we're measuring the platelets, which one of these factors that we have in our blood, So I think they're involved in plotting is the idea of them. Besides a low number of those, what kinds of measurements do you make? That might be a clue as to what's going on. Another important parameter would be the so called the timer. And the diamond is usually elevated in patients who have Trumbo's is, But in these patients, the diamond is really, really high. Indeed, diamonds a kind of protein is I think it is some kind of bio marker that becomes elevated with inflammation is that it's also elevated with information. Two timer effect is very and specific. So a lot off these orders. Leads toe increased the diamond levers. It might be inflammation. It might be Trumbo's is It might be a coagulation disorder. And in these patients, the diamond is very elevated because The coagulation system is so activated. It's not only a reflection off the Trumbo's is it's not only a reflection off the clouds, but it's a reflection off the coagulation activation and the consumption off all the coagulation factors. And so this leads to this massive increase in the diamond Evers. I mean, what's interesting to me the sort of clinical markers that you look for when you have a patient, and they sort of confirmed that there's a problem. A supposed What's interesting is it sounds to me. They don't tell you what's caused the problem. And I know that in this instance you could use collaborated with German scientists who Being looking at samples from other patients as well. And you're trying to build up a picture? Yes, that's true because there is only a couple off off diseases off disorders. Which we know off, which might cost his.

Chris Barrow Sabina Eichinger United States 37 141 cases Wednesday BBC World Service European Medical Agency Vienna Medical University Today Black Sea six years Northern Ireland President Maura AstraZeneca UK Roland Piece Republicans Cove
"coagulation disorders" Discussed on Nature Podcast

Nature Podcast

06:55 min | 4 months ago

"coagulation disorders" Discussed on Nature Podcast

"Knowledge has told me over and over again with that. They're not trying to unduly dismiss these reports of severe reactions. Because if something is happening we need to know especially given that these axioms at least some of the platforms that we're using to come up again if not for booster shots with the covid nineteen pandemic but in future pandemics. So there's a fine line that public health officials are trying to walk right now. Where they're trying to be very cognizant of the fact that there could be real adverse side effects that are happening while also reassuring the public that for the most part. These vaccines are safe. These are very very rare events that are happening and millions of people worldwide have already died because of covid nineteen additionally rare adverse events are the norm in almost every pharmaceutical medical healthcare approach in the world even the aspirin that we take has side effects so this is not new. This is not something that is specific to this set of vaccines. That's very true. And i think that it's also worth noting that just because a rare adverse event happens in one person and you can in one person link the vaccine to that event that doesn't actually extrapolate out to the broader population so one of the goals of these clinical trials that are being done with regard to allergic reaction to the marin vaccines in the united states. And i imagine that this will be true for the other studies that follow with other covid. Nineteen vaccines is. The goal is to assess whether there is a risk at all really dig into that signal and see if they can find it but then to be able to define that risk so that physicians can better advise their and maybe say you know if you've got this particular medical history. Let's not take this vaccine. Maybe let's direct you towards a different platform that uses different ingredient racks by different mechanism. Okay so i think it would be really useful to us. One worked example here and something that we talked about last week. On krona pod was about the rollercoaster. Is what i think. I'm gonna use the describes. What the oxidised zeneca vaccine has been going through over the past month also. Now that's linked to clinical trials. And the way the information was communicated impresses and so on but a big part of that roller coaster has been linked to rare adverse events that were detected in europe. Now this something we mentioned last week but can you just catch us up about what those events were. And then what that triggered the response to that was. Yeah so the european medicines agency has a surveillance system that they used to report adverse events that happen after immunization and what was seen was that in a group of about twenty million people who had been vaccinated with the astrazeneca vaccine that there were twenty. Five cases of people who had some sort of severe blood clot often associated with a lower platelet counts so there seemed to be some sort of coagulation disorder that was happening and so the european medicines agency's did is. They paused the administration of those vaccine. So people weren't getting them while. Experts came together and tried to understand what is the actual risk and one of the things that they did was they compared the rate of these reactions that were happening in vaccinated groups with people who had not been vaccinated to see how often this kind of clot happens just by chance. They actually found in the vaccinated group that rate was lower. If you were looking at chance alone you were less likely of developing one of these clots if you had been vaccinated than if you hadn't but what they weren't able to do was rule out a link so there was an overall assessment the benefit of protection from these vaccines still outweighed. The possible disease caused by kobe. Any risk of a rare side effect but they weren't able to say definitively that the vaccine and the the blood clots were or were not linked now since then more of these reports have been coming in particularly in germany. Where in a group of about two point. Seven million people. They've gotten thirty one reports of some of these plotting events and that's a higher rate so in that case all of the people who had that reaction were women and they were between the ages of twenty and sixty three so germany in a number of other countries at this point have decided that they are only going to vaccinate people in older age groups with the astros vaccine but again we still don't have a link in these countries are working to try to figure out if they can define that risk for this vaccine. Yeah i think it's really important to say that just looking at the real numbers you may say. The rate isn't necessarily hiring people have been vaccinated than in the background. But once you start getting into the details the age of the people you start looking for other trends. That's when you might see a different thing because across the whole population you might expect people that old maybe to have these blood clotting disorders more regularly in younger cohort. It starts to surprising. And that's the kind of detail that these regulators are getting into when they really dig into this data that it's also important to note that it nineteen that the sars kobe virus has actually kind of messed up our background. A little bit. i mean. This virus causes all kinds of adverse events. All on its own including blood clotting disorders. So one of the concerns is that the rate of these clotting reactions the rate of a number of different adverse events may be different now than they were in the before times when there wasn't a pandemic going on in which this virus was widely circulating in the population especially in cases where people have had a symptomatic cases of covid. Nineteen me the in some ways. This is not a comparison. That really makes sense that it does make sense in my head. Some of the common adverse events that we see things like pain in your Things like a headache. There actually indicators that the vaccine is working best showing the the the immune system is being stimulated and in a way the fact that we're finding these more rare adverse events also indicated that the surveillance systems that we have in place a working. I think these are all things that we could actually be encouraged by even though on the face of it then fund on nice to hear about. Yeah i think that is definitely true and what we are. Learning now is new and better ways to communicate this information to audiences who are not as familiar with how these systems work. And i think if anything being able to get folks to better understand how they can go about reporting these adverse events to their healthcare providers or directly to the systems themselves and these agencies are really trying to assess the safety of these vaccines. Everything is working the way that it's supposed to. It's just going to take more time. Thank you so much. These investigations will be ongoing in the meantime. I hope everyone can get hold of that vaccine as they can say looking forward to getting mine and i hope you join us again in the future on current fund. Thank you so much..

europe last week Nineteen vaccines germany Nineteen twenty sixty millions of people Seven million people astrazeneca Five cases thirty one reports united states about twenty million people One one person european medicines european about two point past month
"coagulation disorders" Discussed on THE NEWS with Anthony Davis

THE NEWS with Anthony Davis

05:28 min | 4 months ago

"coagulation disorders" Discussed on THE NEWS with Anthony Davis

"I'm anthony davis astrazeneca said on sunday a review of safety data of people vaccinated with its covid. Nineteen vaccine has shown. No evidence of an increased risk of blood clots astrazeneca's review which covered more than seventeen million people vaccinated in the united kingdom and european union comes off to helpful parties in some countries suspended. The use of its vaccine over clotting issues authorities in ireland denmark norway iceland and the netherlands of suspended the use of the vaccine clotting issues while austria stopped using a batch of astra zeneca shots last week while investigating a death from coagulation disorders. European medicines agency has said. There is no indication that the events were caused by the vaccination of you that was echoed by the world health organization on friday. The drugmaker said fifteen events of deep vein thrombosis and twenty two events pulmonary. Embolism have been reported. So far which is similar across other licensed covid nineteen vaccines. The company said additional testing has an is being conducted by the company and the european health authorities. None of the tests have shown cause for concern. The monthly safety report will be made public on the ama website in the following week. Astrazeneca said the astra zeneca vaccine developed in collaboration with oxford. University has been authorized for use in the european union and many countries but not yet by us regulators. The company is preparing to file for us. Emergency use authorization and is expecting data from its. Us phase three trial to be available in the coming weeks. A third wave of the covert pandemic is now advancing swiftly across much of europe as a result many nations bogged down by sluggish vaccination campaigns a witnessing shop rises in infection rates and number of cases the infection rate in the eu is now at its highest level since the beginning of february with the spread of new variants of the covid. nineteen virus. Being blamed for much of the recent increase several countries announced set to impose strict new lockdown measures in the next few days in contrast to the uk which is beginning to emerge slowly from its current bow of shopping school closures and sports fans in italy authorities recorded more than twenty seven thousand new cases and three hundred and eighty deaths on friday from today. Most of italy will be placed under lockdown and people will only be allowed to leave their homes for central errands. Most shops will be closed. Along with baas and restaurants in france authorities have reported a similar grim situation with health minister alleviate iran describing the situation in the greater paris region as tense and worrying president macron has imposed curfews and other restrictions in several regions and many doctors are now pressing him to introduce a national lockdown as a matter of urgency in germany. Twelve thousand six hundred seventy four new covert infections. Were reported on saturday. A rise of three thousand one hundred seventeen from the previous week as the head of the country's infectious disease agency acknowledged that the country was now in the grip of third wave of covid nineteen the us house speaker. Nancy pelosi on sunday said that the biden administration had inherited a broken immigration system as the administration announced it would send federal help to children on the us. Mexico border seeking asylum celebration by democrats over joe biden signature last week of an historic aid. Package combining covid relief with economic stimulus and anti-poverty programs has been tempered by a surge in the number of young migrants from central america and mexico seeking asylum. Some come from families whose livelihoods have been destroyed by climate change. Pelosi said these people were leaving. Because of the drought they couldn't pham was seeking other ways to survive the biden administration which prioritized reversing the immigration policies of donald trump announced. Late on saturday that it would deploy the federal emergency management agency fema best known for responding to natural disasters to the border to manage and care for the children. Fema agents would assist in the transfer of children in custody within seventy two hours into family homes or homes. That are safe for them to be pelosi. Said a near record nine thousand four hundred and fifty seven unaccompanied children would take an into. Us customs and border protection custody in february according to the agency the most since may twenty nineteen president joe biden has ended the trump era practice of expelling immigrant children. Who crossed the border alone but maintained expulsions of immigrant families and single adults..

donald trump Nancy pelosi Pelosi three thousand saturday central america mexico germany twenty two events february fifteen events fema Nineteen vaccine nine thousand ireland today Fema friday italy last week
AstraZeneca finds no evidence of increased blood clot risk from vaccine

THE NEWS with Anthony Davis

01:46 min | 4 months ago

AstraZeneca finds no evidence of increased blood clot risk from vaccine

"I'm anthony davis astrazeneca said on sunday a review of safety data of people vaccinated with its covid. Nineteen vaccine has shown. No evidence of an increased risk of blood clots astrazeneca's review which covered more than seventeen million people vaccinated in the united kingdom and european union comes off to helpful parties in some countries suspended. The use of its vaccine over clotting issues authorities in ireland denmark norway iceland and the netherlands of suspended the use of the vaccine clotting issues while austria stopped using a batch of astra zeneca shots last week while investigating a death from coagulation disorders. European medicines agency has said. There is no indication that the events were caused by the vaccination of you that was echoed by the world health organization on friday. The drugmaker said fifteen events of deep vein thrombosis and twenty two events pulmonary. Embolism have been reported. So far which is similar across other licensed covid nineteen vaccines. The company said additional testing has an is being conducted by the company and the european health authorities. None of the tests have shown

Astrazeneca Anthony Davis Coagulation Disorders European Union United Kingdom Iceland Denmark Norway The Netherlands Austria Ireland World Health Organization European Health Authorities
"coagulation disorders" Discussed on Shock Wave News

Shock Wave News

05:25 min | 4 months ago

"coagulation disorders" Discussed on Shock Wave News

"So zero hedge dot com and tyler durden. he's He's a watermark over. There is zero hedge very very very good reporter excellent. I recommend reading or adding zero hedge to your Reading campaign if you guys like to read things online and different things. The news over. There's very very very good. So let's get into the article. Europe's much criticized vaccination rollout has hit just another snag. As danish authorities are increasingly concerned about harmful effects believed to be associated with the astrazeneca oxford jab. The cheap covid remedy was supposed to help europe catch up with the uk and israel. Well danish authorities on thursday temporarily suspended astrazeneca's covid nineteen shot following reports of dangerous blood clots forming inside patients including one such instant. The place in denmark authorities didn't specify exactly how many reports of blood clots. There's been but reuters reports that austria Also has stopped using the batch of astra zeneca shots while investigating death attributed to coagulation disorders along with illness attribute to pulmonary. Embolism a condition whereby one or more of the lungs and arteries become blocked with the a blood clot six. Other european countries have also reported halt and halted the distribution of the covid jab Both we and the danish medical agencies have yet to respond to reports of possible serious side effects both denmark and other european countries. The director of the danish health authority said in a statement. The danish medicines agency said the suspension would last at least fourteen days as the authorities launch an investigation into the blood clots with assistance from other e states. They did not say how many blood clots there has been. But austria has stopped using the batch of cas shots while investigating the death from coagulation disorders and illness from pulmonary. Embolism now astrazeneca claims. Its vaccine is subject to strict rigorous quality controls and there have been no confirmed serious advert adverse events associated with the vaccine..

tyler durden thursday nineteen shot zero hedge both Both european uk zero hedge dot com israel danish one fourteen days denmark astrazeneca europe six danish health authority one such astra
"coagulation disorders" Discussed on iForumRx.org

iForumRx.org

05:48 min | 1 year ago

"coagulation disorders" Discussed on iForumRx.org

"Included its randomized double blind placebo, controlled design reducing the risk. Any bias that could confound the results also since this study was conducted in the United States and Canada, and at the patients were managed part of the current age ACC guidelines. The results may be applicable to our general population. Another strength was that they provided a clear definition of STATIN intolerance. The current guidelines do not clearly define stanton intolerance. So the definition used in the study may be applicable to the real world. However I agree that this was a relatively small trial with three hundred and forty five patients although the baseline characteristics both groups for similar about ninety percent of the patient population was Caucasian since high risk ethnic groups typically non-caucasian. Are considered a risk enhancing factor for atherosclerotic cardiovascular disease also patients with complicated co morbidity such as those with uncontrolled hypertension coagulation disorders or recent cardiovascular event were excluded other weaknesses of the study included. It's short duration, which was twenty four weeks long term efficacy and safety data and measuring cardiovascular outcomes are needed to showcase. Ben. PEDANTIC. Clinical benefit. Also, if patients demonstrated poor adherence during the running period, they were excluded from this study which does not reflect the real world. So Janine clear serenity was actually one of the series of studies that examine the safety and efficacy of Penn pedophilic acid. Can you tell us a little bit about some of the other studies in the clear series and whether the findings are consistent with the clear serenity study? Do you think this drug is likely to replace as? which is commonly used as the first hat on agent and patients who don't achieve lipid lowering goals or in patients who are unable to tolerate statins. So there are a total of five clear studies, clear harmony, clear wisdom, clear tranquility, and clear serenity have been published and clear outcomes is currently ongoing. The clear harmony trial was the first study of the series which primarily measured safety. This was a fifty two week trial and included patients with atherosclerotic cardiovascular disease or heterosexual familial hypercholesterolemia. The trial included over two thousand patients. There was no increase in incidence of adverse events in the Ben Pike as a group versus placebo an ldl cholesterol where's reduced significantly. Thirteen point five percent from baseline. Clear wisdom was also a randomized controlled trial measuring ben pike acids efficacy. The patient population was similar to the clear harmony trial and the primary endpoint was the present change in ldl cholesterol from peaceline week twelve, Ben pedantic acid significantly reduce ldl cholesterol by fifteen point one percent from baseline. Third Clear tranquility was also a randomized controlled trial, but it assess the efficacy of the addition of acid to as. In patients with Stanton intolerance patients with an ldl cholesterol greater than one hundred milligrams per deciliter unstable lipid modifying therapy were included during a four week run in.

Ben Pike familial hypercholesterolemia United States Ben Canada Janine
"coagulation disorders" Discussed on WJR 760

WJR 760

08:20 min | 1 year ago

"coagulation disorders" Discussed on WJR 760

"Reversal of artery disease. Dr calendar we've been talking about. What medications Last segment we're talking about what medications is of the patients need to be on to help them a reverse disease and also deal with inflammation. Walt. Thanks, Emery. So Just kind of come back to where we were. We're tryingto prevent people from having a bad covert experience, meaning a prolonged hospital visit or death. So in our role here is preventive health specialists. I want to make sure that you're taking the time to recognize that cove. It is coming back into our state. There's a rise in disease around the country. This. We're going to be hitting a second wave as well as we did in Michigan for a long time. If we're going to be dealing with it again and possibly again until there's a vaccine, and you know, by the way the vaccine's not coming anytime soon, Right? So in the meanwhile You need you need you going to do what you want to do, But I'm offering suggestions to improve your health so that should you become exposed Cove it you're in the best possible situation to recover and survive. So we talked about using specific blood pressure medications that have been shown. If you walk into the hospital with cold bed this is one of the greater indicators of survival is being on an ace inhibitor type medicine. And if you're not on one, you need to find another doctor, because by now they should figure out that's where you need to be Number two, and I've had about four other drugs. I want to talk about there, like always been one of time. But I want to talk about aspirin because the American Heart Association has told everyone if you're over 70 and you think you're healthy, you shouldn't be on an aspirin because the side effects outweigh the benefits. Well, that's nonsense. Because none of you know if you're healthy, you have no idea what your healthcare statuses Unless you're seeing someone like me who can really identify what your health is and what your disease states are. You have no idea. I can't tell how many of my patients stop there Aspirin because I read some blurb in a magazine. Quoting the American Heart Association, and I've got to put him back on the aspirin and reeducate them so It's critical to know where your health is so that you know whether you should be taking aspirin or not. And the reason aspirin is important is because in people with severe inflammatory disease, and I'm going to throw another term out there, which is going to be a focus of what I do. Moving forward is Micro vascular disease. So what does that mean? When you get a heart catherization you do. Ah, You know that type of image ing your arteries the on ly artery in your heart that the cardiologists Khun get to to give you a stent as the large arteries. That you're the rest of this. Maybe 15% of the blood flow to your heart. The 85% is microscopic arteries that they can't see and those Khun become damaged and become ruptured, right? Those are the ones that are susceptible to ongoing chronic inflammation. And so when if you have cove it and you have a severe inflammatory response. You're likely to develop a severe coagulation defect, which is, you know, part of people and people are saying, Hey, the real issues here is in the blood vessels. It's causing a blood vessel coagulation disorder And really, what it's doing is the the massive amount of inflammation that covert is bringing to someone who already has Micro vascular disease is to cause this coagulation defect, which Uses up all their platelets uses up all their proteins that are used in coagulation and they end up dying from, you know, that's just one of the methods of death. Is a is a coagulation problem brought on by the inflammation, So this is a little more controversial, But there are some studies that show that if you are on aspirin walking into the hospital And you, you have a sepsis event. So sepsis is similar to this coagulation problem that you're more likely to survive. Now there's Different studies about covert, specifically an aspirin and their equivocal, meaning. Some say aspirin is helpful, and some say it isn't but aspirin can help. Reduce the again This is not not in the middle of the condition. But if you're already on aspirin, and many developed these covert type situation, you may be less likely to develop a this level of vascular damage that we're seeing with Cove it so it's a very important to know. With your doctor. What the status of your disease is because if you have plaque, you should be on an aspirin. If you have inflammation, you should be on an aspirin. If you are genetically predisposed to heart disease. You should be on an aspirin and I guarantee you none of you are have no any of this about your health. Seeing a traditional doctor through a hospital system or a you know, a corporation probably never discussed. Are there any other medications that you want to talk about? What? We still have some time that your patients are on the people that are susceptible to call that need to be on well. The other drug that was seen on the study is a statin. So the three predictive positive predictive issues with covert and this one study was being a female being on an ace inhibitor and being on a Staten So again, taking women out of out of this equation. Those other two medicines stand specifically those medicines, reduce your body levels of inflammation, so it's not I don't use a Staten to treat blood cholesterol. And and if someone if someone has high blood pressure, and they're hard to these, I put him on an ace inhibitor. What stands in particular. I tell my patients who kids let me interrupt who gets prescribed Stanton's What do you have to have in order to be prospects? Staton medication. This is a whole other show, so okay, but it's basically cardiac problems. No. The health care system right now determines who goes on a Staten based on a formula. So you plug a few numbers in the formula. And if the number comes out this number you a dose ing of the stand. High dose medium does low dose statin based on a formula. Well, I throw that formula away. My answer is Do you and that from those mostly based on cholesterol numbers, So to me, if you have plaque, I don't care what your cholesterol is. You could have the best looking cluster on the world. If you have plaque, you're going on a Staten because a plaque means you have inflammation regardless of your cholesterol numbers, so Now I'm giving somebody who has vascular inflammation. And I mean we're going to say micro vascular inflammation, a drug that reduces inflammation. So that's why in this study People that were on statins walking in the hospital. That was a positive predictor of a better outcome. Whereas all those other disease states we keep talking about Those air predictors of death in the hospital from getting cold bit. So what is there anything else on as Faras medications are concerned that patients need to know the other one is taking vitamin D So vitamin D three really promotes a better immune response. So You know their science that no one wants to hear about. But I am certain tell my patients to use vitamin D three in combination with vitamin K two, and that combination helps reduce vascular inflammation. It helps pull calcium out of your arteries and take about your bones. On DH. There's a lot of different studies that show that people that are on high doses of vitamin D three have Better outcomes in many different disease states and that tells us that vitamin D does help promote our immune system and D three and Kato are over the kind of thing.

aspirin Staten American Heart Association ace inhibitor inflammatory disease Emery Walt ly artery Khun Michigan sepsis Staton Stanton Kato
"coagulation disorders" Discussed on News-Talk 1400 The Patriot

News-Talk 1400 The Patriot

05:13 min | 1 year ago

"coagulation disorders" Discussed on News-Talk 1400 The Patriot

"And click subscribe don't forget to click the bell icon so you'll be notified every time we set up this is pregnant here among the depravity is of the left has been vicious war against hydroxy caloric when there's no doubt in my mind that the left has caused people to die who otherwise would have lived and I am I am certain that it doesn't bother them because hating Donald Trump is a much greater moral good in on the left than saving lives or CBB liberty or saving America it's a sick world and I have another doctor courageous and the prestigious Dr on the issue of hydroxy Clark went on the line Dr Sabine Hassan H. A. Z. A. N. she's a specialist in Gastroenterol logy practices in Ventura California she's used hydroxy Corcoran and particularly dramatic is I have a patient actually distinguished one he is the founder and CEO of coffee bean and tea leaf a terrific coffee shop I that I frequent regularly sunny so soon and I welcome you both to the show a doctor let me begin with this all you hear from the left is study after study shows it doesn't work or actually makes things worse the most recent being a lancet the F. the British prestigious medical journal any comments well I think you know before saying you know last all right I think we need to kind of you know understand how did the land said get into talking about hydroxy chloride Quinta how do we get to this point to begin with I think for me I was intrigued by the stars from the beginning because of the fact that it needed it it went from China Italy to America a different strain and I'm in the microbiome business I tried to understand the gut flora the microbiome understand what changes in our immunity in the gut flora in other words when you alter the balance of the gut flora you get disease when you have a good balance you fight disease this is a virus that is unlike anything we've seen because it does rapidly spread as we've seen and so something is creating that data is making us look at this virus this virus need early treatment early to cure so the earlier you treat the earlier you cure and if you wait for the heart attack to take your cholesterol medication it's not going to work right you don't wait to go to the hospital to take your medications for the heart attack that you should have been taking all along so you write so to me the virus the way I looked at it early on in the game is it has stages it goes from a symptomatic to mild symptoms to dropping your saturation to hospitalization and then becoming a blood coagulation disorder so it's not a one pill is gonna fix that obviously it's not a one pill it's not a one trial what I do as a Gastroenterol this is actually I'm on the cutting edge of medicine because I do clinical trials have been doing clinical trials since my first year fellowship at university of Florida and clinical trials is really going into the a bit of trying to find solutions trying to understand whether a medication works or not hydroxy caloric when when we look at it yes it's safe I mean it's been used since the fifteenth you know rheumatologist users around the world and have written that for lots of patience does it work short term or long term for this virus is it safe short term or long term will we create a resistance therefore maybe create a super virus we've certainly seen that with other box clustered in this the cell which we have to resort to fecal transplant to cure stop or yes methicillin resistant staph aureus so you know when we look at the hydroxy Clark when we have to start for saying okay is this a solution for everyone or is the solution for certain people it's really a patient doctor relationship that's probably one of the reasons I brought this on the on is because I think we have our doctors have been put in this you know what stage of what we have to defend what we're giving patients everybody is different we all have different fingerprints we all have different gut flora how could we possibly require a one pill solution or one solution so hydroxy Clore Quinn yes it will work on a lot of people and maybe and that's what we do clinical trials that I've certainly seen at work on a lot of people but there are other people work that R. G. six PD deficiency that will not be tolerating it there are some people wear their.

"coagulation disorders" Discussed on 860AM The Answer

860AM The Answer

07:01 min | 1 year ago

"coagulation disorders" Discussed on 860AM The Answer

"The bell icon so you'll be notified every time we set up the Finnish Prager here among the depravity is of the left has been this war against drugs chloroquine there's no doubt in my mind that the left has caused people to die who otherwise would have lived and I am I am certain that it doesn't bother them because hating Donald Trump is a much greater moral good in on the left than saving lives or CBB liberty or saving America it's a sick world and I have another doctor courageous and the prestigious Dr on the issue of Hydroxycut lord put on the line Dr Sabine Hassan H. A. Z. A. N. she's a specialist in Gastroenterol logy practices in Ventura California she's used hydroxy Corcoran and particularly dramatic is I have a patient actually distinguished one he is the founder and CEO of coffee bean and tea leaf a terrific coffee shop I that I frequent regularly sunny so soon and I welcome you both to the show a doctor let me begin with this all you hear from the left is study after study shows it doesn't work or actually makes things worse the most recent being a lancet the the the British prestigious medical journal any comments well I think you know before saying you know last all right I think we need to kind of you know understand how did the land said get into talking about hydroxy chloride Quinta how do we get to this point to begin with I think for me I was intrigued by the stars from the beginning because of the fact that it mutated it went from China Italy to America a different strain and I'm in the microbiome business I tried to understand the gut flora the microbiome understand what changes in our immunity in the gut flora in other words when you alter the balance of the gut flora you get disease when you have a good balance you fight disease this is a virus that is unlike anything we've seen because it does it rapidly spread as we've seen and so something is creating that data is making us look at this virus this virus need early treatment early to cure so the earlier you treat the earlier you cure and if you wait for the heart attack to take your cholesterol medication it's not going to work right you don't wait to go to the hospital to take your medication for the heart attack that you should have been taking all along so you so to me this fire is the way I looked at it early on in the game is it has stages it goes from a symptomatic to mops and brooms to dropping your saturation to hospitalization and then becoming a blood coagulation disorders so it's not a one pill is gonna fix that obviously it's not a one pill it's not a one trial what I do as a Gastroenterol just is actually I'm on the cutting edge of medicine because I do clinical trials have been doing clinical trials since my first year fellowship at university of Florida and clinical trials is really going into the abyss of trying to find solutions trying to understand whether a medication works or not hydroxy caloric when when we look at it yes it's safe I mean it's been used since the fifties you know rheumatologist users around the world and have written that for lots of patience does it work short term or long term for this virus is it safe short term or long term will we create a resistance therefore maybe create a super virus we've certainly seen that other box clustered in different cell which we have to resort to fecal transplant to cure staph aureus methicillin resistant staph aureus so you know when we look at the hydroxy Clark when we have to start for saying okay is this a solution for everyone or is the solution for certain people it's really a patient doctor relationship that's probably one of the reasons I brought this on the on is because I think we have as doctors have been put in this you know what stage of what we have to defend what we're giving patients everybody is different we all have different fingerprints we all have different gut flora how could we possibly require a one pill solution or one solution so hydroxy Clore Quinn yes it will work on a lot of people and maybe and that's what we do clinical trials that I've certainly seen at work on a lot of people but there are other people work that R. G. six PD deficiency that will not be tolerating it there are some people wear their medications may counteract with the hydroxy floor Clinton aides are not strong enough to sustain infection one sure we may survive services train one but will we survive strain to will I talk to Clark wouldn't help us four strain one but then will it help us for strange too we don't know okay hold it there if you would doctor this is Valdez the very important unless speaker to your patient obviously wanna remind you folks talking about the getting relief this will mark the cura a covert nineteen but it makes your your chronic pain and that is of course really factor if you're in pain you want out of it and this is something it only believed to sleep through the night it's not a sleeping pill it just will it removes pain for the vast majority of people who take people thank me in the old days when I used to give speeches and meet people before the speeches remember that before the panic to set in of the lockdown well people would thank me for this eight hundred five hundred eighty three eighty four twenty dollars for a three week Quixtar you'll know one three weeks for did you know that precious metals having solid history of outperforming the stock market during tough economic times chatting with my friend he's a very special man Nick Kroll which owner of am fed coin and bullion he warned me there are severe shortages of gold silver platinum right now many dealers have nothing to sell over the past few weeks am fed has helped hundreds of people acquire precious metals I'm one of them right before this by the way my timing was perfect they're open for business with some staff working from home they can get you gold silver platinum at a fair and honest price Nick has been in the industry for over forty years and knows the intricacies of every market condition what to buy now and more importantly what to avoid he is the.

chloroquine
"coagulation disorders" Discussed on Core IM | Internal Medicine Podcast

Core IM | Internal Medicine Podcast

06:49 min | 2 years ago

"coagulation disorders" Discussed on Core IM | Internal Medicine Podcast

"Actually focused on on making sure the patient was okay. He wanted to know about vital signs ortho statics hemoglobin after that he starts exploring the other categories in his schema he asks for the platelet platelet count and the complete haemogram as you recall she was a nemec but play. The cat was normal. Again doesn't really sound like a platelet disorder because it's it's a late in recurring during while the mineralogy a- <hes> mental meteorology i think is typical of von wilburns disease since it's late and recurrent leading and that makes me think more of a bleeding disorder or a local soft tissue disorder instead of looking down the unwilling brand syndrome pathway again if she did have a pathology i would call i would look there to see. Is there something else there right. That's left behind <hes> but if i can't do that then i think since since she's the then. I think i'm going to start doing acid. Coagulation essays just to point out quickly. This is the second time that he's emphasized the delayed eight onset and the recurrent nature of this patients bleeding. It's a critical clue that the problem lies not in the formation of the platelet plug. I e primary hema stasis that would cause immediate media bleeding again. He's already suspicious for soft tissue disorder but with theology report pending he plays along and he starts to order coagulation studies. There are some simple tests and arm tariam that can be helpful in terms of thinking about bleeding if if i want to do my deductive method and we have our program and time and are partial toronto classes time respectively both of them can be helpful and thinking about the common final pathway of the ignatius cascades and the <unk> the program in time for the extrinsic seven factor seven seven a and and the p._t. For intrinsic which i think are <hes> eight nine eleven rain nine eleven twelve plus the common pathway so what what is the p._g. Is this laboratory is twenty three point nine again that laboratories towards so these being normal it doesn't totally rule out a coagulation disorder but it makes it less likely that it is something to do you with <hes> next radically intrinsic pathway could be factor one receptor to <hes> if it was a vitamin k deficiency although that can affect factor which it also affects factor seven and nine and ten or might even k. deficiency generally doesn't occur occur with <unk> just malnutrition or usually malnourished and on his office speaking of which she is her diet okay cindy the way he explicitly talked about the factors here kind of stuck with me. He could have just asked for the p. T. n. p. t. instead he runs through the factors that contribute to each before asking for the results a surprising. I mean that's the way it was taught in medical school. No i'm not saying it's arcane knowledge. I mean yes. I also remember the factors for med school. Maybe maybe with some effort i don't i'm sure you could recall them with some effort <hes> and but to be honest somewhere in the ten years between when and we learned the correlation cascade today my brain just decided to stop caring about which factors were part of what pathway and i justified this by saying that in the real world old as a general internist being able to see an isolated p._t. Prolongation for example and just recognize okay. That's an extrinsic pathway problem. I should think about war friend in vitamin k deficiency liver disease so most of that time that abridged model of pathophysiology that is good enough in daily practice. You're seeing it's almost it's like there's a level pathophysiology. That's not worth remembering once. I entered a clinical world certain things just don't apply in real life anymore. I mean don't tell my medical students. I said that but yeah basically feel like pathophysiology is kind of like an ocean i could dive deeper and deeper but beyond a certain indepth it's just too dark and uncertain and cold and style. I drown so that's why i was surprised that are discussing has the factors the factors in working memory. He retrieves those details with such ease and there's a part of me that wondered like why does he bother to remember that. Should i bother a number that isn't it distracting. This became a recurring theme during our interview over and over again. Dr watson would get very granular in his discussion of pathophysiology geology and while cindy. I certainly entertained the possibility that this was just because his teaching mode was engaged. He has a reputation within our group for just having prodigious prodigious prodigious knowledge it honestly it felt like more than that. It felt like these asides were in fact part of his diagnostic process. It wouldn't be it's less likely to be i think tight one von will of iran's where you get factor depletion but acquired von will brands disease with like a a <hes> <unk> whether it's from a high flow state or a like a white arabic para valvular league or a mile plastic syndrome drome they often have they will have a normal willa brand factor level normal receipt tests and i don't really remember exactly race details of normal factory in p._t. But they're losing their large von will rams factor multiple errors that under the most important ones in terms of clotting. That's something i would think about <hes> so so did she get an evaluation for that. It just to remind you of those results. Remember both the quantitative and qualitative gillibrand factor assays were normal as was the factor eight activity essay so it makes makes it less likely but it's not sensitive at all for certain conditions and the problem is the diagnosis is made by this von labrum molterer her say that is usually not done in most hospitals in his operator dependence i would if i think she has acquired von willow branch his one the reason why right so i'm still looking i'm going to say that's less likely but look for something that would cause that so by this point.

soft tissue disorder vitamin k deficiency ignatius cascades iran p._t med school gillibrand liver disease p. T. Dr watson cindy ten years
"coagulation disorders" Discussed on WIBC 93.1FM

WIBC 93.1FM

08:13 min | 3 years ago

"coagulation disorders" Discussed on WIBC 93.1FM

"New medication to treat haemophilia and is a new class of medicine just approved by the FDA and some say this could be a game changer for managing the rare bleeding disorder, Dr Shapiro. Good morning. How are you? I'm Gary good. Thank you for hosting us today. We're happy you're here. And we're gonna talk about that new class of medicine, but the challenges of treating hemophilia a what is what is Huma feely, a hemophilia a is a coagulation disorder or a deficiency of one of the clotting factors. It is a. Rare disorder in that it affects less than two hundred thousand Americans. It is a disorder where you are either missing or have a decreased amount of the clotting factor factor. Eight it is the most common form of haemophilia that we see in the community. And there are quite a few hoosiers who are affected with this disorder that we care for is it something you're born with. Yes. Congenital hemophilia is a genetic disorder. And it is something you're born with Amy. How does someone know if they have hemophilia you just get cut one day and can't stop bleeding, or is it something that shows other symptoms? What actually it's other symptoms for the most part cuts are not a bleeding events that present with patients with hemophilia for the most. Part people with haemophilia have excessive bruising or deep tissue and muscle bleeding. Now, the types of bleeding events, really depend on the level of severity, and there's quite a range of severity associated with him affiliate. So what we're most familiar within the community is severe disease where your levels are less than one percent. But there's also moderate disease for the levels can range from one to five percent and mild deficiency where it's about five percent and less than forty five percent. So the way you present in the age at which you present really depends upon the level of severity that you have. So you can present at birth. You could present as an adult with bleeding with procedure, for example, a dental extraction. Many patients that we diagnose have a known family history. And so we're looking for it in an individual who could be affected a baby. Born to a mother who is a known. Carrier of this disorder some individuals present because they have excessive bleeding was circumcision or he'll sticks or other procedures in the newborn period. Other people present within the first two years of life. And then again, it depends on your level of severity when you might come to attention is it is it is mostly found in males. Yes. The majority of patients who are affected with Musalia are males but women who carry this disorder who have one change, gene. The gene is on the x chromosome so women have to waxes men have an x and why that's why males are predominantly affected. However, women who carry this can have levels that range in the mild deficiency category and therefore can have bleeding symptoms as well. And so many women who carry hemophilia also received care through our. He Musalia treatment center here because their levels are low enough to put them at risk for bleeding with procedures or other events. This is Dr Amy Shapiro. She's the medical director of the Indiana hemophilia and thrombosis center, and she joins us on the HP dot org phone line this morning. So what is life like for someone that has been diagnosed with hemophilia, a, well, let's talk mostly about our severe patients for patients with severe haemophilia like is certainly better than it was twenty years ago, but it is still somewhat difficult. The mainstay of therapy has been the replacement of the deficient clotting factor, which is administered intravenously and needs to be administered on a regular basis to prevent or suppress bleeding episodes. This can be difficult for people at all ages and stages of life for young children because of the Venus. It's access issues and the need to worry about what kind of activities they might participate in to protect them from bleeding episodes. And as you get older, it's also difficult because the time and the work it takes to make sure that you are protected with regular infusions can be difficult to adhere to or interrupt your life. You might make choices about activity or work that are based upon your hemophilia. So this new therapy really is a game changer for patients with severe hemophilia who have needed or required. Prophylaxis which is a regular infusion of factor concentrate in order to protect them or suppressed, the bleeding episodes. They experience Dr Amy tells a little more about this new treatment it's been almost nearly twenty years. So what's changing now? Well, actually, I've been taking care of patients with haemophilia for thirty five years. And this is really a big change patients have been as I said, the mainstay of therapy has intr- has been intravenous you administration a factor concentrate. This new therapy called he libra is a novel therapy that is administered subcutaneous Lee, which means under the skin much like diabetes medication would be administered the medication itself takes the place of factor. Eight inqui- Galatian and after the loading doses you achieve a steady state level without those peaks and low levels, especially those low levels at put you at increased risk of bleeding. So you have this steady state level all the time which really provides the best prophylaxis we'd seen in patients with. Haemophilia today. So it's really novel for young kids. This worry about intravenous access is just bypassed for a lot of our adults who have been on this medication. They just really say it's been life changing in terms of how they feel how they conduct their life. The activities they've been able to participate in one thing I will say is all medicines have side effects, and it's very important to speak to your physician about any potential side effects. When you're considering the use of this novel agent libra. So where does anybody go for more information before we let you go? How can they find out more about it? Well, there's lots of information there if you just Google it you will find information on the web about the licensure the manufacturer Genentech has information on their website. I believe we're putting up information on our website as well, which is dot org. And there are scientific articles that are available on PubMed. If anyone has a desire to read more detailed information, well, Dr Amy Shapiro. That is exciting news. It really is. She's the medical director of the Indiana hemophilia and thrombosis center in this new medication treating hemophilia A patients. So good to have you with us this morning. Thank you for the good update. Thank you so much for having you bet. Well, that about does it for us here on caregiver crossing caregiver crossing with a t h crossing caregiver crossing. Wasn't busters name Mike Tyson Dyson. It's.

Dr Amy Shapiro Dr Amy Indiana medical director FDA Huma feely Gary Musalia treatment center Musalia Mike Tyson Dyson diabetes Google Genentech Lee HP five percent twenty years forty five percent thirty five years one percent