23 Burst results for "Chima"

"chima" Discussed on DNA Today

DNA Today

02:13 min | 2 months ago

"chima" Discussed on DNA Today

"Relation of people over the age of sixty percents of aging skeletons is very very hard determining whether they did die of cancer if site what sort is also very very hard is not representative relations. But i think there's some interesting questions and it certainly seems like the mole people looking the counselors in ancient human remains of ancient animal remains The more that finding and just this week tonight just as we Where we're talking in august. There was the announcement that they found a seventy seven million year old dinosaur also with an austere south. Chima say this stuff is old and the fact that we find any of it is ready. Suggestive felt it was if not massively prevalence reasonably in the august. That's an exciting finding that we're seeing again in in different species but also from long ago and obviously as you said there's a lot of limitations when it comes to getting dna and looking at it with skeletons because of just how old it is and what are you finding but as you said just being able to say oh it looks like this person did have cancer and so long ago that is valuable in itself. And i'm i'm interested to explore if there's a relationship between the genes that are correlated with cancer and many of them we know of in the field and how long those genes have existed in terms of are these genes being highly conserved across species. Are these cancer genes seen throughout the animal kingdom or are we seeing more like there's human cancer genes and then there's other genes and other species so the basic what we would consider to be jeans. The kind of the drivers all life. So they have the genes that are involved in ration- at the genes that are involved bike. Overriding celta. that revolted toss moving south route. And so i think those are the same across all species because ultimately you know we all came from one cell with the same undiminished set of mechanisms that make cells multiply in. The cell. Cycle is incredibly conserve..

Chima cancer human cancer
"chima" Discussed on NewsRadio 1020 KDKA

NewsRadio 1020 KDKA

06:39 min | 2 months ago

"chima" Discussed on NewsRadio 1020 KDKA

"Piper here of medical frontiers, and it's dark, Rob. It's dark, and we change those clocks. Did you enjoy that extra, actually, Believe me when you get up when I get up on the weekends and take an extra minute of getting there you go. The Steelers did okay. Excellent. Yeah, they are. It's not real good. If you have heart problems, broad, broad approach. Urged up like that. The watch The watch the Steelers because they sure keep it exciting. They did. But tonight we're gonna be talking about how can we plan for the holidays in the midst of the Koven 19 pandemic. How can we have a sensible, safe and hopefully pleasurable Thanksgiving and Christmas? Get together? We're gonna be talking about that with Dr Tara Chema and Dr Chima is a pulmonologist and he's the director of pulmonary critical care sleeping allergies division in the In the area of pulmonologist. So welcome to medical frontier of Dr Chiba. How are you? Thanks for having me. I'm good. How are you guys? Oh, great. And, um We have a couple holidays coming up. You were in the month of November and the last Thursday of the month. We're gonna be celebrating Thanksgiving and most people in the country I believe. Like to celebrate Thanksgiving and then you know the next month. We have Christmas and What? What can we do, Doctor Shima to do some celebrating, not go overboard, but and still be safe A cz individuals when we have family gatherings, and so what are some of the tips that you could give our listeners? I'm sure you know. So you know this year is going to be different. You know, 2020 has already proven to be really difficult and unique year for all of us. Um, and it's not over. You know, As you know, the numbers have been going up for a covert cases. And over the last two weeks, we've seen a surge throughout the country. Um, you know, the recognition is at this point. You know not to cancel Thanksgiving plans or Christmas plans, but we need to be careful and use some common sense. So you know, if we can limit the gatherings to our immediate family members, that would probably be the best way to approach it. But if we are unable to do so, and you have family members coming from outside, the best way to kind of have an enjoyable family get together would be Silty, social distancing 6 ft Apart. You know, even their mask indoors, but somebody who's coming from outside and you know it. Continuously wash your hands when you are able to You know, those are the common sense things that we would probably have to do to get through this, okay? And actually those air things that we should be doing every day, you know, And maybe maybe not so precisely when there's no pandemic, but but we always have to make sure that our food is prepared properly that we don't get food poisoning. That we continue to keep our hands clean with her without Ah, pandemic, and that type of thing is stay away from very large crowds, especially well during the flu season. That makes sense with the common flu season. As well as with the covert pandemic doesn't not That's correct. I mean, I think by doing all of these measures, you know, we're also hoping that we are able to reduce the number ofthe floor influence about infections as well this year. Because you know, they can also cause a lot of problems to our older folks of relatives, barren So that is definitely something we also are worried about. Okay? And we also would like to get your take on how you feel about the seasonal flu vaccine that is available now. Yes, I think you know it's always important to get the flu vaccination, But this year it has an extra importance because It's not only for protection off yourself, but you don't want to overwhelm hospitals. If you know you have suddenly see an increase in patients with the flu. Because they take up hostel beds to be expecting a lot of competitions come in. They also start to see some cases where people are ineffective at both covert and influence at the same time. So as you can imagine, Corbett is bad enough. But if you get the flu on top, if it it can definitely make things much worse. So this is something you know. Easy. We have a vaccination available, you know, traditionally in the United States team of 40 to 45% of people get the vaccination. This year. We're hoping that the number goes way up so we can completely eradicate influence our flew from the equation when we're dealing with a covert. And I I don't think another statistic that that folks Ah, don't hear enough When we talk about the common decisional flu is that people could die from that. That they can also get very, very ill need to be hospitalized. Have respiratory problems have to be put on a ventilator, etcetera, etcetera. You in your career, You've probably seen people who have been very, very sick from the common flu. Oh, that's absolutely correct. You know, it's interesting in a regular flu season, we lose about 20 to 25,000, you know, patients a year. You know this from a regular flu season? Mm. You have a bad flu season. That number can go up to about 40,000 year and those of the people is dying. But we also have patients coming in who end up on ventilators, Bad pneumonias. So the flue can be quite dangerous as well. And we need to kind of attention to that as well. So that's what the you know when we have an easy way to prevent it by a vaccination. You know, I would recommend that everybody go out and get a vaccination as soon as possible. Okay, and we've been with his pandemic now for seven months or so, and And we've learned a lot, but there's probably still a lot. We need to learn that the patients are being hospitalized now. Dr Chima are they as Sick as some of those patients were initially back in February, March, April spring of this year. Our we've seen cases that need to be his hospitalized but aren't quite as sick is the first batch later..

flu flu vaccine Steelers Dr Chima Rob Dr Chiba Dr Tara Chema Doctor Shima United States director Corbett
Game Scoop

Game Scoop!

05:15 min | 6 months ago

Game Scoop

"Okay? Let's talk about what we've been playing I know at least seventeen on Ivan playing ghost of Sakina just their view. Our interview a came out this week. got a nine from Mitchell ends. Everybody seems to be really really enjoying it. I know I. Am that also true for both of you? Hands Down like gotta be the most gorgeous game I've ever played. It's very pretty. It's very pretty. I mean there's just there's firefly's everywhere. They're like little butterflies. flapping around the attention to detail is amazing, but like even when you're walking over yellow like yellow leaves from from falling from the trees you can see. They're like sweeping up behind you and they go faster as you run faster. It really is amazing to look at 'EM SALMON I. We're talking about this at some point off. Scoop. and Sam mentioned like it's such a bummer when it's nighttime because you don't get to see all of all of this like loveliness and all its glory. But. Yeah, understand are really cool, but sunny day really really makes things amazing in that game, and then there's these moments where like I I mean they sat when you go into a story, they set the time for that and that's like a trick they're using because sometimes you're like in the the golden forest area, and everything's like autumn looking because y'all. It's like all seasons at once in that game. And and you. The Sun is like as big as the screen is. Gold and everything is silhouetted in, and it's just like it's unbelievable, but it's still an open world game, and that'll just happen. Naturally were moving around. It's like the thing that breath wild did which I thought was really cool. Which says well is the wind like like these Grassy Plains, the wind looks amazing, sweeping through them, and there's giant fields of flowers, and you keep like our. That's probably going to be the most beautiful. Beautiful place in the game and then they went up it with like another field of flowers has cool rocks in it or something, or they have like a swarm of starlings that is the most realistic depiction of a swarm of birds have ever seen in any games in any way just looks incredible analytical. All three of those elements that you mentioned are also gameplay elements. The bird heads the flowers and the wind. The wind actually really liked that. They use the wind to tell you where to go. Yeah although really cool mechanic. Yeah, it's really windy and my Sushi Malvo because I'm just like. Wait. What direction wait am I going the right way? My Hair's total again. Just miserable, be a nice summer fall, maybe autumn or Spring Day, but it's just a little bit chilly because of that wind. I'm playing it coming immediately coming off of last part too, so it's a little bit interesting. compete playing those games one after the other last of his party was really like shooting for the stars and trying to get do something different. Give you an original experience play with the way narratives working games play with your expectations, trying to do all this new stuff or as ghosts of Sushi. Shema I feel like it's just a very traditional open world action game, which isn't a knock against it at all I just feel it's like the AAA open action game refined to perfection. It's honestly the breath of fresh air that I was hoping for following the. Exactly that kind of air. Thank you. Breath of fresh wind. Because I mean aside from all this stuff about like the last of us being this really like dark and brutal world that depicts humanity in such a like depressing perspective go Sushi Shema is pretty much the opposite of that in a lot of ways but I like like I'm going really slowly through the main story beats actually because I. Love The side quests in the site. I'll give you something different. level you up in different ways, or you can get legendary armor and weapons with some of the. Specific side quests so I I just love being in the world and spending as much time as possible searching everywhere like looking for all the little elements of the story that are living in these tiny pockets as opposed to the loss of us, which is just as like grand big cinematic experience, also you use triangle really dominantly in the last of us for like access points like opening doors, or whatever, and then in goes Chima. You are, too, so I have definitely accidentally hacked the hell out of my poor horse, trying to mount it, which which sources you big or jumped off the Horse I. Yeah! I picked the white horse and I named him Nobu for trust. three two three horses that you get to choose from Black Arstan puffy. That's exactly what I have class. Hacking I. Aside from the beauty of the game. I think there's a little bit of like Damon was saying like what? What's an open world RPG going for like it is trying to? It's more like assassins creed in anything else, but I I personally like it better than assassins creed I think it's like a a because I like the sword combat. Now it's been frustrating for a very long time, but now I have like these multiple stances. Stances them switching through. It's really fun. I found the way that I like to play, which is rolling a lot and dodging instead of parrying which I just suck at I'm just so bad at that and a better fighting games, too. I always knew like I. Play Friends. Wednesday got good at blocking and like street fighter two. I'd be like well. I can't play anymore I. Just don't like I'm out

Ivan Mitchell Grassy Plains Shema Black Arstan Chima Damon Scoop. SAM
The Power of No

Optimal Living Daily

04:18 min | 8 months ago

The Power of No

"Sirens were beautiful creatures from Greek mythology who lured sailors to their death the power of their songs so irresistible it 'cause captains to steer their boats into the rocks and drown. We're all seduced daily by ideas that sound great at first but may leave us shipwrecked unless we have the power to say. No investor Mark's sister recently warned about the perils of shiny new objects. Everything you say yes to is incrementally one more thing to support and you die a death by a thousand cuts. He says quote. I strongly believe that your success will be more defined by what you choose not to do than by what you choose to do. Of course what you choose to do has to be meaningful timely valuable prescient and high quality and quo. Why we say yes when we mean no Michael. Hi it says. There are three common responses to people who ask us to do things. We don't want to do number one accommodation. We say yes when we want to say no. This usually comes when we value the relationship of the person making the request above the importance of our own interests number to attack. We say no poorly does is a result of valuing our own interests above the importance of the relationship. Sometimes we are fearful or resentful of the request and overreact to the person asking her three avoidance. We say nothing at all because we are afraid of offending the other party. We say nothing hoping the problem will go away. It rarely does personally. I've always felt that being asked to do. Something was a measure of your fitness and status but some people will ask anybody when they need something because they know. There's no loss and being told no tim. Colony of the foolish adventure recently wrote about how self-doubt prompted him to say. Yes too often. I let those fears manifest into taking on too many projects so I can't do them to their fullest says calmly quote a little here me there and quote and as a result calmly says he finds himself in the fifteen percent of businesses. That are doing okay. Not Great better than the eighty percent of businesses that are failing he says but far from the five percent that are crushing it and where he has been in the past saying no is saying yes to freedom having the confidence in foresight to say no makes you stand out when you have clear. Goals is easier to say no. I'm actually as proud of the things we haven't done as a things I have done. Steve Jobs said at the nineteen ninety seven worldwide developers conference quote innovation is saying no to one thousand things and quote. There are lots of good ideas out there. None better than your own well executed plans. We often say yes instead of no when we doubt ourselves and our intentions when we say no to requests we freer selves to work on the things we value. Now what other people think is important. And that's the power of no no as powerful because it's rare near a all wrote about how scarcity can boost desire. We want what we have. Psychologists call this the scarcity heuristic when we are rebuffed. We want will. We can't have even more. They'll always be great new opportunities. The better you are what you do. The more people will want you. The more you say no the more you reinforce your value but say no can sometimes mean not right now is a grand founder. Kevin System turned on a personal offer. From Mark Zuckerberg to be one of facebook's earliest employees does move could have cost him hundreds of millions of dollars. Assist trump believed in his own vision and staying in school was the right. Movers future as luck would have it. He was right and facebook later. Bought his company for more than enough money to put any regrets to rest. People want to be liked. We don't want to offend rather than say no we'd rather string people along and hope they get the message some day but nothing is more clear than stating our intention. It shows respect self worth and conviction no is about you and no one else. The more clear our goals become the easier more powerful each no becomes saying no taste practice and it may backfire but to me is the ultimate side There are one thousand things will need to say no to in your life.

Mark Zuckerberg Facebook Steve Jobs TIM Michael Founder Donald Trump Kevin System
Biohacking India: Sleep, Jet Lag, Hidden Environmental Killers, Air Pollution, Antiviral Tips, Eating For Longevity & Much More!

Ben Greenfield Fitness

03:40 min | 10 months ago

Biohacking India: Sleep, Jet Lag, Hidden Environmental Killers, Air Pollution, Antiviral Tips, Eating For Longevity & Much More!

"In today's episode. I want to instead focus on what I got up to during my recent trip to India where fortunately I came back safely and managed to get back into the US before any of the travel was quarantined. And I was able to take part in some fantastic. Qna's and panels over there and the one that you're going to hear today is one of the better ones so we spent over two hours not only replying to really educated and informed questions from the audience about biohacking sleep fitness beauty symmetry jetlag etc. But then we also did a panel and the two gentlemen who you will hear along with me on this panel are Jag Chima and Kris. Gethin two guys who actually toward India with and we did a panel in both Delhi. Which you're about to hear and then also panel in Mubarak and was recovered. A bunch of extra information and I'll also be releasing that episode for you soon But jag himself is an entrepreneur. He's investor. He's a big health and fitness personality. Who has done a lot in the health and fitness space particularly in Asia? Although he's based out of London and then Kris Gethin who you'll also here on this podcast. A new friend new acquaintance of mine former bodybuilder and editor of bodybuilding DOT com. Who was one of the best natural pro bodybuilders in existence and now he does a lot of personal training with Bollywood celebrities and billionaire businessmen and a lot of athletes. He has a whole chain of gyms as well over in India and so between Me and these two guys. We covered a ton of stuff. Everything that you're about to hear is going to be over at Ben. Greenfield finished dot com slash Delhi. Qa that's in case. You don't know how to spell that famous city in India de L. H. I. Qa so if you go to bed angry dot com slash Delhi Qa. You'll be able to get the robust show notes for everything that we discuss in today's show all right so in addition to that I have a very very cool announcement. We just launched at kion one of the most well researched proven supplements in existence for enhancing the health of your brain staving off muscle decline increasing testosterone boosting performance boosting power boosting muscle mass increasing heart health the list of benefits from this particular product. That we just launched. Its it's staggering. I've been using it for twenty years since my bodybuilding days and have been waiting for the perfect purist version of it to finally be available and it is now available and we've managed to get our hands on it and packages for you at kion so the supplement in case you haven't guessed it is creating but we have gone way beyond creating we've taken a special form of creatine monohydrate in a form called CRAP. Heure which has stringent manufacturing standards and very precise analytical control and use that to create the most efficacious creating. You're ever going to get your hands on. There's no loading necessary. There's no cycling necessary. You just launch right into this. You start taking five grams per day and it is amazing. It's the gold standard for creating. And if you combine this with Arcane economy knows especially if you're going after this from a performance and a recovery standpoint totally gangbusters total game changer. I don't think I can throw any other descriptive terms out there without a exhausting my

India Mubarak Kris Gethin Delhi QNA Jag Chima United States Asia Testosterone Editor London Greenfield
"chima" Discussed on Sounds of Science

Sounds of Science

10:43 min | 1 year ago

"chima" Discussed on Sounds of Science

"Cancer Research is a complex in ever evolving field one of the most promising research areas involves the habitat that cancer is able to create for itself which is known as the tumor micro environment to discuss this topic. I've brought in Vienna Jenkinson Director of Science at Charles Rivers portishead site. She has over a decade of experience in the fields of oncology and immunology and she has agreed to talk with me about what exactly the tumor micro environment is and and how we can exploit it to treat cancer. Welcome rhiannon thank. You see me to stay today. Thank you for coming. So let's just start with the basics six. What is the tumor micro environment? So when we think that chairman Momaday on we often maybe think of all of tumor cells so quite a genius in the way that it's formed and these cells really foam from our normal cells which being incorrectly programmed maybe gone bad resulting in them growing up normally taytay an affecting the normal function of our organ all tissue but really the reality is a lot more complex as often is in these scenarios. I'm really uh not more different cell types get recruited by the missiles into the moncur environments to the tumor cells themselves along with these other south types. And the extra study in a mate checks at the cell. sit-in form the Cheema Might Kerr environments so then that raises the question of what are the cell types in the tme. and and why are they. They're severely if we think of the Cheema styles what they're trying to do is survive on and gray said to do this. They need gray. Factors this nutrients and sell staff is signals from types. So as they grow they send out signals and this results in other cell types coming to the Cheema not an infiltrating into the sort of Chima cells to form a tomb amass in addition in the Magrao's it might results into she strasse S. or dangerous signals and this results in the immune system which is constantly surveying the bulge coming along to see what's going on and that rain really is which tax help on these dangerous signals resulting in killing of the Cheema cells so the body is like attacking the tumor but is the tumor able to use news. Those attacks to its own advantage sometimes. Yes that's right side. Whilst I hope would be that the immune cells come in an act against the Shema resulting in killing the reality. Is that the tumor fights back against this. And what it does is generates immunosuppressive environment. Soup one in Wichita riches. Switches the T.. Cells off on the other immune cells and really on subverts them to support the Does this immunosuppressive effect extend then beyond the tumor micro environment to the rest of the body or is it pretty localized. It tends to be localized to the actual Chima micro environment itself. Because we've got to remember that the cells the at the a very very specific on full the tumor itself so it generates sort of a small niche weather cells. Become we'd programmed an influenced by the environment itself. So what does having all of these different types of cells present help us. When we're thinking about ways to inhibit tumor growth? So when we're thinking about inhibiting CI mccray we can think of to on strategies very broadly so the first strategy and the one that's traditionally Russian people total. When they were thinking of drugs? That could talk at the Cheema. would-be Chuma intrinsic mechanisms. So those would be therapies. which would die? We talk the Cheema sales but now we can think about hole of a subset of therapies and these are the ones that will be talked to the other cell types which within the Cheema Might Cram Graham varmints best supporting achievement rife so if we can impact on that function then then now supporting the Cheema and we can even turn theirselves against the Cheema and then that way we can fight back. So it's like you're killing the protection around the tumor and therefore leading the body. Do its natural natural thing and defending against the tumor. Yes that's right so effectively. We're reactivating on the immune response as it is and we will send may be switching the phenotype five of some of the other cell types. which in the Huma so we can think as well as the immune system we can think of the vascular cells? The within the Cheema Might Kerr Garment. Nice saleslady that and they form the Bulls of the blood vessels. They supply the medicament new chance. Perhaps that could be a target cutting off the food supply yet and changing the metabolism. So you could think about strategies by talking yourselves we can say. Think about lymphatic. endothelial cells those form part and emphatic drainage they're taking away debris and metabolites from the tumor itself essentially keeping the environment mclane so again if we could impact on that then we might impact on the amount of danger signals that the chew Miss Generating Sort of the other cell types would be cancerous icy I took five glass. So CAIN FIBERGLASS and normally they're voting but these ones have been subjected to produce despite fat to lay down extra study in a matrix such smooth muscle up ten Collagen If we could talk at these cell types than we talk potentially attention to the framework in which sits and again. It's sort of just about mobilizing those cells and reprogramming them effectively to stop then and helping matchy mccray okay. So we've got the cells. That are helping the tumor get fed. We've got the cells helping. Keep the tumor environment clean. So what would the role of immune cells be in trying to create a therapy based on targeting the tumor micro environment. Tma Chima micro environments often contains on several different types of immune cells. But as we just mentioned the tumor really acts to switch these cells off it wants to survive that wants to grow and then the opposite of the immune system. It's coming in there. It's looking for danger. Signals nuys the team as abnormal. So it wants to go back to its job of killing the Cheema Sales The the two must sort of in a way that it's able to educate on the immune cells ineffective be switched them all in a goal that you have the selective pressure of having the immune system and then the tumor adapts to type with sales in the micro environments support. We often end dot webs Chima which has been infiltrated by mean cells. He's at the team. has actually influenced these cells to become regulatory uh-huh suppressive or switched off and clearly the role of a lot. It's therapies with Ben's Bay either to switch southbound colon ole to drive an the influx of new fresh immune cells into the Environments Obesity just get cells sort of right into the Tumor Micro Environment Rothman perhaps just sitting around the edge itself. There's a few different strategies. We can thank cope when thinking of the immune system in the context of Chima environments. So when you're talking about this tumor micro environment. It sounds pretty complicated. And if we WANNA make therapies is based on this this data it sounds like it would be really difficult to test. So how would we go about testing a therapy. For targeting. The tumor micro environment. Yes so if we want to develop therapies. Of course we have assays allow us to model the tumor micro environment And test if the cell type that with targeting with having the effect that once upon that so I mean all we regulate function changing is ability to survive life. Oh for example we allowing recruitment fresh cells to the tumor cells and increase kidding on of the missiles. So you can think of several different approaches here on these are employed route discovery on early sachin academic research. I'm really okay. We can start off by thinking of simple seller says. I'm by that I mean if we can always relevant cell types I for example from Peripheral Blood Raj then we can isolate to perhaps grow it in a dish. Therapy can then be out in. We can assess for the effect of that novel. Therapy take for example on the function of that cell so is it better able to produce cytokines that we know are involved in producing sort of evect affect t cell function and impact on Chima growth. But those those sort of assays quite simple and it's not taking into account the Hall Hall on Chima Mike Grimm Bramante so so really what we then want to move on and do is introduce several different south types into the act say to Betham auto the environment will be in the bulging So an example of this would be if we isolate t-cells And we also you have to missile line so then we coach those together. We have Chima sale on the sales that we want to enhance that functioned. Kill on the Cheema cells then our readouts with that in that site would be all the T. cells more active are they decreasing missile numbers and they increasing the amount of Killing within the ASA and we want it to that with time on using various APPs ice again. That's just two cell types and we've just talked about that you've micro environment containing lots south lights so the ideal and there are lots of people incubate how investigate this would be if we could have a more complex on in vitro system soaking the dish. We can happen on different cell types in together. Add in the Thera I pay and then look and see whether we're getting that desired effect on for example immune system at Driving Jean-michel so based on studies as that have been done. Does there seem to be any specific type of cancer that this is might be most effective against so it really depends on what you're trying to target the in terms of sedate. The she missed that people have worked with these being. Melanoma for example was one of the first. This one's on of a solid Chima types Often for the T.. Cell directed therapies..

Cheema Cheema Might Kerr Garment Cancer Research Vienna Jenkinson Director of S rhiannon Charles Rivers Chima chairman Momaday mccray Wichita mclane ASA gray Bulls Magrao
Tumors and their Entourage: Exploring the Tumor Microenvironment

Sounds of Science

07:17 min | 1 year ago

Tumors and their Entourage: Exploring the Tumor Microenvironment

"Cancer Research is a complex in ever evolving field one of the most promising research areas involves the habitat that cancer is able to create for itself which is known as the tumor micro environment to discuss this topic. I've brought in Vienna Jenkinson Director of Science at Charles Rivers portishead site. She has over a decade of experience in the fields of oncology and immunology and she has agreed to talk with me about what exactly the tumor micro environment is and and how we can exploit it to treat cancer. Welcome rhiannon thank. You see me to stay today. Thank you for coming. So let's just start with the basics six. What is the tumor micro environment? So when we think that chairman Momaday on we often maybe think of all of tumor cells so quite a genius in the way that it's formed and these cells really foam from our normal cells which being incorrectly programmed maybe gone bad resulting in them growing up normally taytay an affecting the normal function of our organ all tissue but really the reality is a lot more complex as often is in these scenarios. I'm really uh not more different cell types get recruited by the missiles into the moncur environments to the tumor cells themselves along with these other south types. And the extra study in a mate checks at the cell. sit-in form the Cheema Might Kerr environments so then that raises the question of what are the cell types in the tme. and and why are they. They're severely if we think of the Cheema styles what they're trying to do is survive on and gray said to do this. They need gray. Factors this nutrients and sell staff is signals from types. So as they grow they send out signals and this results in other cell types coming to the Cheema not an infiltrating into the sort of Chima cells to form a tomb amass in addition in the Magrao's it might results into she strasse S. or dangerous signals and this results in the immune system which is constantly surveying the bulge coming along to see what's going on and that rain really is which tax help on these dangerous signals resulting in killing of the Cheema cells so the body is like attacking the tumor but is the tumor able to use news. Those attacks to its own advantage sometimes. Yes that's right side. Whilst I hope would be that the immune cells come in an act against the Shema resulting in killing the reality. Is that the tumor fights back against this. And what it does is generates immunosuppressive environment. Soup one in Wichita riches. Switches the T.. Cells off on the other immune cells and really on subverts them to support the Does this immunosuppressive effect extend then beyond the tumor micro environment to the rest of the body or is it pretty localized. It tends to be localized to the actual Chima micro environment itself. Because we've got to remember that the cells the at the a very very specific on full the tumor itself so it generates sort of a small niche weather cells. Become we'd programmed an influenced by the environment itself. So what does having all of these different types of cells present help us. When we're thinking about ways to inhibit tumor growth? So when we're thinking about inhibiting CI mccray we can think of to on strategies very broadly so the first strategy and the one that's traditionally Russian people total. When they were thinking of drugs? That could talk at the Cheema. would-be Chuma intrinsic mechanisms. So those would be therapies. which would die? We talk the Cheema sales but now we can think about hole of a subset of therapies and these are the ones that will be talked to the other cell types which within the Cheema Might Cram Graham varmints best supporting achievement rife so if we can impact on that function then then now supporting the Cheema and we can even turn theirselves against the Cheema and then that way we can fight back. So it's like you're killing the protection around the tumor and therefore leading the body. Do its natural natural thing and defending against the tumor. Yes that's right so effectively. We're reactivating on the immune response as it is and we will send may be switching the phenotype five of some of the other cell types. which in the Huma so we can think as well as the immune system we can think of the vascular cells? The within the Cheema Might Kerr Garment. Nice saleslady that and they form the Bulls of the blood vessels. They supply the medicament new chance. Perhaps that could be a target cutting off the food supply yet and changing the metabolism. So you could think about strategies by talking yourselves we can say. Think about lymphatic. endothelial cells those form part and emphatic drainage they're taking away debris and metabolites from the tumor itself essentially keeping the environment mclane so again if we could impact on that then we might impact on the amount of danger signals that the chew Miss Generating Sort of the other cell types would be cancerous icy I took five glass. So CAIN FIBERGLASS and normally they're voting but these ones have been subjected to produce despite fat to lay down extra study in a matrix such smooth muscle up ten Collagen If we could talk at these cell types than we talk potentially attention to the framework in which sits and again. It's sort of just about mobilizing those cells and reprogramming them effectively to stop then and helping matchy mccray okay. So we've got the cells. That are helping the tumor get fed. We've got the cells helping. Keep the tumor environment clean. So what would the role of immune cells be in trying to create a therapy based on targeting the tumor micro environment. Tma Chima micro environments often contains on several different types of immune cells. But as we just mentioned the tumor really acts to switch these cells off it wants to survive that wants to grow and then the opposite of the immune system. It's coming in there. It's looking for danger. Signals nuys the team as abnormal. So it wants to go back to its job of killing the Cheema Sales The the two must sort of in a way that it's able to educate on the immune cells ineffective be switched them all in a goal that you have the selective pressure of having the immune system and then the tumor adapts to type with sales in the micro environments support. We often end dot webs Chima which has been infiltrated by mean cells. He's at the team. has actually influenced these cells to become regulatory uh-huh suppressive or switched off and clearly the role of a lot. It's therapies with Ben's Bay either to switch southbound colon ole to drive an the influx of new fresh immune cells into the Environments Obesity just get cells sort of right into the Tumor Micro Environment Rothman perhaps just sitting around the edge itself. There's a few different strategies. We can thank cope when thinking of the immune system in the context of Chima

Cheema Cheema Might Kerr Garment Vienna Jenkinson Director Of S Chima Cancer Research Rhiannon Charles Rivers Chairman Mccray Wichita Momaday Gray Bulls Mclane BEN Magrao Rothman
"chima" Discussed on Entrepreneur on FIRE

Entrepreneur on FIRE

17:47 min | 1 year ago

"chima" Discussed on Entrepreneur on FIRE

"To fire nation ensure something interesting about yourself that most people don't know oh hey or so fire nation super excited to be here to share some music in blockchain technology mass you guys one thing that most people know about me is I'm actually or retired army veteran I served in the army fifteen years and retired as a finance officer captain well thank you for your service Chima really appreciate it on this veteran run podcast right here and I'm pretty excited nation because she was going to talk about how blockchain stole the music note and what it means for the music industry and so much more having a great conversation with Chima about his past about his president about what he sees the future holding for him and other artists as well as entrepreneurs unless you art with blockchain being the future of the music industry is that the case Shima is is blockchain is on the news us of late as a matter of fact most people probably watching the stock market go down right now also heard about something going up and it's called Bitcoin so it's just not what blockchain holes long chain for office music industry professionals and even folks that are selling merchandise calls the key torts called smart contracts which is awaited transact and have visibility as formal ledger so familiar perfect that is happening right now but it hasn't taken off to the extent that I've gone and that's why we're holding this blockchain just old music note Massa clashes educate folks and let them know the possibilities are blockchain presents them well let's maybe start with that then what is it xactly is blockchain like just kind of break that down for the listeners and then let's kind of move into whether blockchain Ken betoken is for music and maybe some examples of that that's fantastic so blockchain basically what it is as you know we're heading into wards call in an web four point Oh it's a way to have digital certificates when computers communicate basically the under level of security that you put into blockchain is going to determine to what extent the computers communicate and within the backbone you can then have applications that are late appeared without blogging and that's why specifically focused on something called smart contracts basically like you doing contracts between two parties but in this cage you have variables is GonNa determine what would happen if oh certain transaction takes place so that's kind of in a general term what blockchain is on what the future is for the music industry let's give some examples about what look alike to actually be quote unquote token is for music so maybe give a little breakdown on what does it mean to be tokenist and some examples of people that have done it are doing it we'll be doing it soon great yes took mutation is basically solving a problem and then turning that into some people could participate in for example if you wanted to solve a problem that's in terms of royalties for example you have music on spotify and it plays and you get streaming royalties however it takes a while for US actually get paid that royalty as took mutation can come into place where you write a smart contract as tied within an actual walk-in that's a coin so whenever people listening to music and you earn royalties it Dan trigger a payment using our coins of payment platform people actually doing this right now are not that may need as a accompanied by name of vets and that particular company actually's aren't when I did a little research is run by the latency music industry and what I'm trying to get most independent artists to realize that you don't necessarily have to go with the traditional record companies to leverage blood chain and also be independent in today's music industry I'm also working on a project called pod bomb coin that's expensively fronted token is using blockchain to help artists become more independent so that's kind of an example broad-based example now thirty thousand feet but in respect to all the industry's CEO wanted to solve a problem for example will live here in Tampa Bay area in Florida it's a lot of congestion would speak to traffic center to solve a problem that would enable people to actually you know bind Tuesday or coins tokenism gives them an incentive to maybe right public transportation I was set up a token coin and using the blockchain ecosystem now what I like to explain as this two different ways you can develop coins within blockchain using different platforms so most people that I know the ATM program and it's this is free to develop on applications coins and again like I said the Russian with talking about Bitcoin bitcoin his he eight thousand og Levet Anat up a sheer so people can develop using bitcoin but for the most blockchain's and tolkienites from that they're under the coins they're using the assistant to do it so let's get a little specific here about the ability for artists to do things for income generation in the future like what are you seeing coming down the road like you'd mentioned something about you know songs being tweeted for Income Jenner ratio like what is that look like and what are some other opportunities you're seeing you know four artists but again fire nation hope you're listening really realizing that this is for artists but this is also entrepreneurs that are creating moves that are building an audience so speak to that Chima fantastic question US Amerifactors best way for artists the full of ecosystem this pretty much infancy is to start by creating a wallet. Nfl Ledger is not just about royalties but it's it's fair transparent for example if you were to cash a check and you know takes a while for you skin apple wallet utilize the actual address within that wallet to start transferring digital currencies back and forth that gets them comfortable with the whole idea of using blockchain and says this quake the next step and what I would recommend eh artists do right away a stir set up an online platform even entre entrepreneur that's a wittig actually sell their digital music and you have a way to collect payments that's tied to say our wallets based than what could typically happen with your fans come out there and make purchases that transaction will then be utilized the legislation Saudis how long it takes to actually get paid when you actually sells a service or a physical product and I'm not plugging shop before nobody takes typically days that happen competitor the platforms out there so using that that a scenario I can foresee a future where artists would completely bypass traditional stores or the transition streaming platforms in terms of really having their music and their merchandise being put out there for sales and also how fast can you get paid so I foresee a future where the record companies are not going to be as powerful as they are right now because if you think about it most of the creation distribution and Hello Promotion of music is done on a global scale five Rick Accompanies I pretty much I don't want to call them monopoly before the fallen intensive purposes that's what it is because if you look at how digital music has trended over the last ten to fifteen years the silicon valley companies that came into the ace had to sign contracts with the big record companies and so that's why you have a royalty system that's what I call Jurassic is really old ripe for disruption and I think that's what blockchain Carson small contracts is going to do for audits go forward so fire nation we're talking a lot about what is going to be the turbo not talking about thirty forty years on the line we're talking just over the edge I mean this is cutting edge stuff this is going to happen and for those artists and just entrepreneurs in general you need to start understanding this lingo understanding what blockchain is understanding what it means to be token is understanding how to use all of these great features of her coming down the road to benefit you and your business and we haven't even started with the value bombs Cheema is going to drop into some great great knowledge when we.

Nfl apple Rick Cheema Carson fifteen years thirty thousand feet thirty forty years
"chima" Discussed on WBAP 820AM

WBAP 820AM

02:08 min | 1 year ago

"chima" Discussed on WBAP 820AM

"It's called midnight misfits. And it's not one of these long ponderous, eighteen minutes twenty minute for our thing. It's very short. And it's to the point. And it's how you and I can stay in touch the other way, we can stay touches every Email. I get gets answered Walter m sterling Chima, Walter m sterling CI male, and I have a Facebook page and on the Facebook page right now is a poll. You know, what a covered dishes potluck is. It's where you bring the food gather with a bunch of people in a room who have a common interest you eat the food. And then you go home that to me sounds like an ideal promotion one where you provide the food. I'm thinking of having a a potluck a covered dish. Hot dish at an elks club. At various cities in the country. Kansas City Camby Z, Philadelphia WPA, Portland decay, a UFO, I'm thinking of different places to have it and WB in Dallas. Where we would get together late on a Sunday afternoon. You would bring a covered dish potluck, whatever you wanna call it. And we'd all share. And then we tell Larry stories, and yes, I would invite lesbians lesbians space would be available and we get to spend some quality time. I've always wanted to have a meet and greet gathering a gathering of midnight misfits because no one else cares about us. I mean, the only club you, and I can get into the home shopping network club, and they stopped calling that club be the home shopping club. Now, it's a home shopping networks whole thing they threw us out really pretty much the only club you, and I get into is the midnight misfit club. I would love to do that with you. Now, there was a study. But there's a poll Walter Stirling. There's a pole go there decide whether or not you would come. You would bring a dish to an elks club. And we could have some quality time together. I would do it in August. I would do in August because I need months and months to promote something I'm only on Sunday. Nights. Why am I only on Sunday nights?.

Facebook Walter m sterling Chima Walter Stirling elks Philadelphia Dallas Kansas Larry eighteen minutes twenty minute
Trump sues to try to keep two banks from giving financial records to Congress

John Reid

00:28 sec | 1 year ago

Trump sues to try to keep two banks from giving financial records to Congress

"President Trump and his family are suing to banks to keep them from turning over financial records subpoenaed by congress looking into possible foreign influence in US elections ABC's John Santa Chima Kratz as Deutsche Bank and Capital One for records related to the trumps and their business earlier this month, but in a new lawsuit. The first family is asking the banks not to comply saying lawmakers are only seeking to quote, harass. The

Deutsche Bank And Capital One John Santa Chima Kratz President Trump Congress United States
The burden of pancreatic cancer attributable to smoking

SpaceTime with Stuart Gary

01:05 min | 1 year ago

The burden of pancreatic cancer attributable to smoking

"Cancers could be traced back to smoking and most could be preventative current smokers would quit the findings reported in the medical journal of Australia. Looked at the cancer and death registries to obtain date or more than three hundred thousand people they found that Carrington recent smoking explain some twenty two percent of all future pancreatic cancer burden with a figure being much higher for man. A new study by Danish. Researchers concluded that low does aspirin doesn't appear to reduce the overall risk of death from prostate cancer the research full at other studies which had suggested that aspirin could be used to improve survival in patients with prostate cancer. But those study results were considering conclusive. The new study did find that men who had a top of prostate cancer. That was unlikely to progress were at a slightly lower risk of dying than they pays who did not pop the aspirin pills. However and attached at a to'real in the journal of the study annals of internal medicine suggested this lowered risk could simply be explained by inaccurate Chima. Grading. And you study concludes that the world's

Prostate Cancer Aspirin Journal Of The Study Annals Of Medical Journal Of Australia Carrington Twenty Two Percent
"chima" Discussed on KOMO

KOMO

02:43 min | 2 years ago

"chima" Discussed on KOMO

"Tokyo, you can take the express, which is actually thirty bucks one way. So if you get the JR rail pass, you have to get that get it here, they signed they give you they send you the paperwork. And then once you arrive in Tokyo, then you go to a JR rail pass office, and then they activate it. Oh, good tip there. And I found online you can get it at Japan rail pass dot US. It's one of the many websites that you can find just Google Japan rail pass there are several agencies who do sell them. But I do want you to keep in mind that you want to make sure that you are clicking on the accurate, accurate one. And it's Japan rail pass dot U S, I went through JTB USA dot com. Perfect and the TB USA dot com be accredited businesses. And that's something that you want to make sure. That you are on the lookout as well. All right. So a couple of minutes left in this segment. So tell us traveling on the Shinkansen super easy, it's super comfortable super comfortable. And also there's two levels on the past. You have the regular pass the green pass. Okay. We got the green pass is that business is concerned. It's it's a little bit higher class. But you can reserve your seat. Now. This is important because when we went from Osaka to hero Chima, we had to do a stop the one constant that we can go on did not have the preserve seating. So without the reserve seating. We had to try to get on the train or they ran out of reserve seating. We had to get on train. So we were with the masses were when you're with the masses. There's no seat. Right. So I basically had to stand for about an hour halfway between Osaka and hero, Shema seven people laugh. So if you can pay a little bit extra I think, it's like a hundred bucks. More get the green car- pass this also WI fi in there too, and you can plug in and everything like that. It's it's it's a little bit more comfortable, it's a little easier. Do you have to make reservations before you? Go. So you go to the office to say, I'm I'm going on these dates, oh and also know the tip if you're going from Tokyo to anywhere west going the right side sit on the right side because you might get a view of Mount Fuji. Did you? Yes. Oh, very very brief. Yeah. Because because the mount rainier sometimes it out sometimes it's not out. Yeah. And so when we pass by it, so we got a nice view about food because you pass right by it. I love those tips that you posted a lotta pictures on your Instagram page. Go ahead in and plug yourself there at yams TV like yams like yams, like sweet potato yams yams TV at yams. TV? You could check out some of his pictures from Japan. We're going to chat with riot. A lot more on the tips coming up as you travel through Japan as we continue on this adventures await here on this Sunday here on.

Japan Japan rail Tokyo Osaka Mount Fuji Google USA Instagram JTB USA WI Shema Chima
"chima" Discussed on KOMO

KOMO

01:46 min | 2 years ago

"chima" Discussed on KOMO

"And that's something that you want to make sure. That you are on the lookout as well. All right. So a couple minutes left in this segment. So tell us traveling on the Shinkansen super easy, comfortable super comfortable. And then also there's two levels on the past. You have the regular pass the green pass. Okay. We got the green pass is that business is that. It's it's it's a little bit higher class. But you can reserve your seat. Now. This is important because when we went from Osaka to hero Chima, we had to do a stop the one content that we can go on did not have the preserve seating. So without the reserve seating. We had to try to get on the train or they ran out of reserve seating. We had to get on train. So we were with the masses. Well, when you're with the masses. There's no seat. Right. So I basically had to stand for about an hour halfway between Osaka and hero Shema until some people left. So if you can pay a little bit extra I think, it's like one hundred bucks. More get the green car- pass. You there's also WI fi in there too, and you can plug in and everything like that. It's it's it's a little bit more comfortable, it's a little easier. Do you have to make reservations before you? Go. So you go to the office to say, I'm I'm going on these dates, oh and also another tip. If you're going from Tokyo to anywhere, west go on the right side, sit on the right side because you might get a view of Mount Fuji. Did you? Yes. Oh, very very brief. Yeah. Because because the mount rainier sometimes it out sometimes it's not out. And so when we passed by it, so we got a nice view about food because you pass right by it. I love those tips that you posted a lotta pictures on your Instagram page. Go ahead in and plug yourself there at yams TV like yams. Why gams.

Osaka Mount Fuji Instagram WI Tokyo Shema Chima
"chima" Discussed on Talk 1260 KTRC

Talk 1260 KTRC

11:22 min | 2 years ago

"chima" Discussed on Talk 1260 KTRC

"Many of you probably took classes from him. He kept you in school Santa Fe high school. Now, these that New Mexico school for the arts, Joey, see Richardson, great to see you. Thanks for having me your actual title over. There is director of art director of arts Cynthia department chair. All right last time, you were here you had a playwright in town. You guys were presenting her play. And it was about Lockerbie attract women of Lockerbie, easy, never mind like a steel trap. I still got it rich. How was how was the how was that whole thing? It was a fabulous released. Love the play. She talked to talk back afterwards to the audience talked about the the writing of the of the whole peace, and then gave me some private coaching about the the work. And then it was really taken with the performances of the young actors. All right. So she took notes and in in in credit and critique. Your job is the director and their jobs as as performance, she actually she said some questions of how we arrived at the decisions we did. Or didn't. She say Joey that was one of the one of the most frequently performed plays. It's one of the top one hundred plays right now. Kind of amazing. Yeah. Are you proud of your kids afterwards of absolutely? Yeah. They were fabulous. All right. We're either of these two young ladies in it. Oh, no. They were in another play directed by Barbara hatch. Well, you know, very well. Yeah. She did the well. Why don't you tell them? All right. Who wants to go? First we have Jaden Chavis here. No relation we found out. And we have me. But she no now, Ben Millette Melina is from Espanola and Jaden is from Albuquerque and they ball commute to New Mexico school for the arts Jaden start with you. What grade are you in? I am a junior, right? And you you commute take the rail runner every day that is commitment to school for the arts, y you could just go to school in Albuquerque. I could but New Mexico school for the arts is so unique the schools worth it. I mean, I wake up at four forty five in the morning, and I get home at about seven in the evening at school. I can say changed my life. And so I think that in one way, honestly, what in what way I think it changed the trajectory of my life. It opened doors for me, it gave me connections to people who I never would've met. Right. I'm able to connect to young local artists like Malaysia who I never would've met any other way except for through the school. And he started in what grant I started as a freshman. So this is your third year. Yes, you go all the way through senior year. Yup. Chances a graduation. Our fifty fifty. I think they're a little high fifty afterwards. What do you wanna do? What your trajectory trajectory? So I want to go to college after high school. I'm not sure where I'm doing some research colleges right now. But I'm hoping to stay in theater as a technician a playwright and actor all of it. Why why did why did it hook you? I just love making people laugh. It's my favorite sounds new comedies. You never do draws. I mean, I do dramas I've written a few. But comedy is just what what keeps me motivated, right? And so professional in the theater somehow in is in your something in theater favorite playwright at this point your young life. Right. I I'm not sure if I have a favorite player I ever comedian, John Mullany that was easy. John Mullany is one of my favorite comedians ever comedies. Aren't Joe you ever to comedy only in plays. I never tried to do this kind of thing. But she does have perfect attendance coming from Albuquerque everyday. Really? Yes. What do you give for that anymore? Like big doughnut? Not like, all right and me. Yeah. You commute all the way from what grade are you in? Oh, I'm a senior an MSA, but I actually commute from Chima. Oh, oh, oh, really you drive though. Yes. Because you're senior. Yeah. And the first two years of high school, I actually drove to Spinola and then caught the bus to you wrote the blue bus, and then I wrote the blue bus to the plaza. And then I walked the rest of the way to school. Both of you are incredibly dedicated you. So now you drive down from it's not a bad dry. It's not too bad. I mean, it's pretty there's a lot to look at you like living in. Yeah. I mean, we don't really call it a town. It's more of a village should've. Yeah. I you ever eat it down Rancho. Yeah. You want? Good red chillies. Classic. Stay in theater doing theater now. Yeah. You're out in springtime will I don't know. Yeah. Well, if you're gonna make Jones she's gonna make it. Dedicated. I'm I'm doing it. Right. Yeah. And then what college? Yeah, I'm gonna try to go to college. We'll definitely going to go to college and study psychology and theater and social work. Why do you what do you make the extra effort to go to New Mexico's goal for the arts when you could go to Aspen Lavelli? Well, I think that there's not a lot of opportunity in Aspen, ULA. And I think the coming to New Mexico for the arts, I was pushed a lot harder than I would have been anywhere else. And I think that it definitely got me to think about what I wanted for my future a little bit more. Which both have in common. Obviously, you come from very well connected and wealthy families because New Mexico school for the art is only for the rich kids. Right. Joey that is absolutely the wrong thing to say, Richard. No where the a public high school, and we take students from around the state all over New Mexico, New Mexico. We have currently have a sophomore in the theater department. Who's all the way from silver city? Lives here during the week during the week. I hope they. You would never be home. No, she's yeah. She's at the dorms during the week. And then there is a host family here because the drive is so long back and forth. She would be in the Carlo weekends right in the dorms or up Chris across the road from from prep. Right. The immaculate heart Mary retreat center. Never remember the name of that. Yeah. All right. So why are we here today? Joey well about why are we got week a couple of months ago, Roger Montoya from moving arts Espanola reached out to MSA to try and partner with other organizations that present arts and cultural events throughout the northern New Mexico corridor. So this Friday at five o'clock at northern New Mexico community college theater, we're going to have they presentation with a number of different organizations from towels SP Nola for walk Cam. Then Santa Fe we'll be sharing work and little kids up to up to teenagers and adults. So it's not just for high schools. But it's so that people in northern New Mexico can kind of see what is available out there. So families might be able to see something it be interested in and might want to explore a little bit more of that. So anything involving the arts anything involving the art not necessarily theater, not necessarily. It'd be it could be weaving. They could be weaving. There's going to be pottery. They'll be danced there'll be music w theater presentations. I know there'll be some Flamenco going on. So it's it's a it's a nice share. Yeah. Yeah. And free dinner. It's a free event. Then afterwards, we are going to open the doors to the annex where they'll be table set up from the different organizations, so parents and children and grandparents can learn more walk around. All right. And once again takes place on Friday. It's Friday this Friday. Five to eight PM. That's great welcome. Every open to the public open to the public all free. Yes. Outrageous. What will you guys be presented? Well, used to Dayton me talk a little bit because because she knows Roger very well at moving to art Espanola. Okay. Well, I'm gonna be I worked with Mr. traumas on monologues over last trimester. And so I'm going to present one of my monologues loop from what it's from the play little murders by Jules Pfeiffer in the role of Patsy. Can we do thirty seconds? It's only a ninety second monologue. Can you can you assume the character pass you real quick just do one of the drop into character? And and give us the little, okay? I'll give you the reversers on. Don't screw it up. Honey, I'm not trying to hurt you. I'm trying to change you. I'm trying to save you. I wanna make you see that. There's some value in life, some beauty some tenderness. Something worth reacting to something worth feeling. Very good. What's again, the play is little murders by Jules Pfeiffer? Okay. You're going to be doing something. So Mr. Chavez is gonna retaking me along with one other student as a student technician. And so I'll be helping with the technical aspect for the event can do light sound all those kind of things. Yup. Props curtains, whatever they need doing the the backstage stuff. I do. I do. I've I started doing technical theater about a year ago. And it's this whole time. It's been so you you do some of that during during school for the arts productions. Yes, I actually I ran lights for the women of Lockerbie. And I'm also doing the light design for the show that we oh we have coming up. What about working outside the school like get at Dobie rose or one of the local theatres that going because they're always they're always looking for tax, right? I did a board up physician at armory for the arts. I've done some light design. Adobe broS. I'm actually I'm currently working on a light designer only CEO that's opening right? So I I work I work around theater as an intern over there. That's great great training over there. They've they've pretty fancy equipment computerized equipment all digital equipment at the Lindsey Graham, right? That's right. At school for the arts. No, we do not we we. We don't have enough power in the building. So how do you how do you control the lighting there? Well, we have a very small board, and we had to learn which circuits we could plug into around the building. Actually, we have cable. Host to turn on the microwave. The microwave is the death. The we then we use the power right away. Right blow a fuse, right? So you'll be the two of you, and Joey you're going to do what Mr. Chavis you're going to be. I should call. You Mr. Chavis in front of the student? Mr. Chavez, my dad, you can call me Joey of the so are we take another student Ben Rowntree as another technician he was also with the Lennick, and what I want them to do is actually get the experience of being in a different theater and working with different equipment. Absolutely. Can you guys? Hang absolutely back. We had one request for the eagles and one requests for pink. Floyd you can figure.

New Mexico Joey Espanola Jaden Chavis Lockerbie Mr. Chavez Santa Fe high school Albuquerque Jules Pfeiffer technician John Mullany director Roger Montoya Santa Fe Malaysia Barbara hatch Lindsey Graham Ben Millette Melina Spinola Chima
"chima" Discussed on WBAP 820AM

WBAP 820AM

01:53 min | 2 years ago

"chima" Discussed on WBAP 820AM

"Or. I mean. Vaguely legally legally, we're not allowed to my understanding is we're not allowed to shoot the thing. Unless it's coming after our pets. The law is silent in Texas about shooting coyotes or any similar to have animals, but if you got your dog, and you think you dogs being threatened. That's why Rick Perry are, of course, our former governor when he shot and was jogging. It was one of my Chima thing he shot and killed the Coyote that was on the trail that was that. He felt like it was an attack his little dog nothing wrong with what he did. So I mean, I don't I don't I advocate people walking around and think comes after after you shoot and kill it. Go out there with your LTCB. You know, if you ever if you have a license Kerry and walk do your walking come to you and shoot it for comes at you. Yeah. The guy the expert quote unquote in the Dallas Morning News article says well if the Coyote attacks you use your knee or get a rape whistle. He literally wants us to get a rape whistle. Are rape whistle either. Here's the options. If you live in Frisco, hide in your home or get a rape whistle. I say Carey walk around and kill the dang thing. Eight hundred two eight eight WBZ AP's our number eight hundred to eight eight nine two two seven. So here if you do walk or jogging the affected area considered carrying something that makes a loud noise to scare off the animal like an air horn or whistle. Frickin rape whistle again, guys. Alp hal. Oh. All help. Yeah..

rape Rick Perry Dallas Morning News Alp Kerry Frisco Texas Chima Carey
"chima" Discussed on Sex Talk Podcast

Sex Talk Podcast

03:02 min | 2 years ago

"chima" Discussed on Sex Talk Podcast

"Talk radio and listen to it Chima spoke about something that women often go through on supported the menopause. Let's go back and listen to what she had to say. So. I've been doing research on HIV in the menopause. About full years now, and that work really came about because I was seeing increasing numbers of women in my clinic who I'd looked after during pregnancy here now reaching their full teas and fifties and coming to me and say, well, I'm feeling all of these things what could this be? And when we talked about menopause women were asking me. Well, is it different because I'm living with HIV, and I didn't have the answer to that. No one had really looked to in the UK. And so that really prompted us to set up the prime study, which was a three study to look at the impact of the menopausal women living with HIV and the results really fascinating say firstly women couldn't wait to talk to us about menopause because no one had ever sat down and told them about it for and there were some really striking findings. So we found that between seventy to ninety percent of women. That were in our study had some degree of menopausal symptoms. We found those symptoms were associated with being psychologically distressed. And also was linked to not being able to take HIV medication. Very well. And we also found that nearly fifty percents of the women that we included in our study said that they haven't ever received enough information about the menopause, and that's a really easy thing to fix. So the results of the study had been quite striking. I think really beginning to help shape. How we provide care to women aging with HIV because of course, that needs to be different to those of men. So you not only had this. Totally. And did you take part in this study? I wasn't old enough. And that point I wasn't even Perriman pools ally, I became permanent Puzo lost year forty five which when you hear about the minute pools. It's like, I think if like over fifty so it just wasn't on my radar, really. And I think that whilst I agree. There isn't enough information out there on the menopause. I think women need to be accessing these conversations earlier than currently is happening because I think and fifties it's not something on paper tickets attention to because I literally just had no information. So I've gone through real Princess in the last year, and particularly found it a pleasant experience to be honest, and memory thing is is probably the most difficult symptom that I have struggled with with the menopause. The knock on affects vice like, it's really impacted my confidence..

menopause HIV Chima UK Puzo ninety percent
"chima" Discussed on Sex Talk Podcast

Sex Talk Podcast

03:02 min | 2 years ago

"chima" Discussed on Sex Talk Podcast

"Talk radio and listen to it Chima spoke about something that women often go through on supported the menopause. Let's go back and listen to what she had to say. So. I've been doing research on HIV in the menopause. About full years now, and that work really came about because I was seeing increasing numbers of women in my clinic who I'd looked after during pregnancy here now reaching their full teas and fifties and coming to me and say, well, I'm feeling all of these things what could this be? And when we talked about menopause women were asking me. Well, is it different because I'm living with HIV, and I didn't have the answer to that. No one had really looked to in the UK. And so that really prompted us to set up the prime study, which was a three study to look at the impact of the menopausal women living with HIV and the results really fascinating say firstly women couldn't wait to talk to us about menopause because no one had ever sat down and told them about it for and there were some really striking findings. So we found that between seventy to ninety percent of women. That were in our study had some degree of menopausal symptoms. We found those symptoms were associated with being psychologically distressed. And also was linked to not being able to take HIV medication. Very well. And we also found that nearly fifty percents of the women that we included in our study said that they haven't ever received enough information about the menopause, and that's a really easy thing to fix. So the results of the study had been quite striking. I think really beginning to help shape. How we provide care to women aging with HIV because of course, that needs to be different to those of men. So you not only had this. Totally. And did you take part in this study? I wasn't old enough. And that point I wasn't even Perriman pools ally, I became permanent Puzo lost year forty five which when you hear about the minute pools. It's like, I think if like over fifty so it just wasn't on my radar, really. And I think that whilst I agree. There isn't enough information out there on the menopause. I think women need to be accessing these conversations earlier than currently is happening because I think and fifties it's not something on paper tickets attention to because I literally just had no information. So I've gone through real Princess in the last year, and particularly found it a pleasant experience to be honest, and memory thing is is probably the most difficult symptom that I have struggled with with the menopause. The knock on affects vice like, it's really impacted my confidence..

menopause HIV Chima UK Puzo ninety percent
"chima" Discussed on 710 WOR

710 WOR

01:49 min | 2 years ago

"chima" Discussed on 710 WOR

"So this man has a chance if he has prostate cancer and most likely he does of being cured and living normal healthy life. So you can think about what would you do? And I suspect you'd probably do that little biopsy to save your life. Life. Life is so precious. Life is so beautiful life is a gift and here. He is petrified. Not to get workup. So I smoked him at length. I tried to explain how simple the biopsy is how in comparison to saving once life is so minute. He said he's gonna call me back. I hope he does. I hope he meets. I hope we can talk in person. And I hope we can if necessary if he has cancer work to save his life as the work that we do at radio surgery, New York. And by the way, you can look at our data across the board not only for prostate cancer. But we have a separate booklet he'll be happy to mail to you a few discuss a call during the workweek booklet about our data and technology, some people call and say, well, what do you do for prostate cancer while no we're not that way? I know there's cyber knife centers you walk in the door. There's one game in town. Proton beams centers there's one game in town surgeons there's one game in town. That's not the way we practice because there's different levels of prostate cancer number one. There's. Different prognosis. Some people are very favorable prognosis above a very aggressive cancer. You don't need to treat them all the same doesn't make sense and some men one an easier treatment some and one more aggressive treatment. So we say, and we mean it the prostate cancer treatment at radio surgery, New York with Dr Liederman is custom tailored for you is custom tailored for your prostate. Custom-tailored for your desires Chima can be as low as forty five minutes. You can come in have an entire treatment for prostate cancer and be out the door within the treatments. Forty five minutes three out the door, probably in two hours..

prostate cancer New York Dr Liederman Chima Forty five minutes forty five minutes two hours
"chima" Discussed on 106.1 FM WTKK

106.1 FM WTKK

02:13 min | 2 years ago

"chima" Discussed on 106.1 FM WTKK

"Saturday afternoon regarding district Twenty-one councilman Vitalis land Chima he said the county attorney had let him know that land Shema cannot hold the seat and run for office since he's currently running for Nigeria's house of representatives. James also say that the metro council will vote Thursday, if they want to ask the attorney general to review the situation if the. Attorney general agrees land Shema cannot be a council member while running for office in Nigeria then he'll go to court avalanche at removing the council if that happens land shame. We would be given the opportunity to give defense. He is a lame duck councilmen at this point having lost the democratic primary for seat in may. It's eight thirty two at News Radio. Eight forty W H A S a man recovering from being shot multiple times that shooting happening at six Sunday night in the seven hundred block of Lampton straight officers arriving to find a white man is twenty suffering from multiple gunshot wounds. The man was conscious and alert while being taken to university hospital is condition as of this morning, unknown the shooting happened outside of a home at that address. And it's unknown. Whether the victim lived in the area. No one else was hurt. And there are no arrests or suspects at this time. Senator dick Durbin wants to see Saudi Arabia's embassador expelled in response to the killing of journalist Jamal kashogi we expel formerly expelled, the Saudi ambassador from the United States until there is a completion of a third party investigation into this kidnap murder, and God knows what followed a pairing NBC's. Meet the press, the Eleanor Democrats said he wants to see the punishment go into effect tomorrow morning. As part of a broader effort to send a message to Saudi leadership about kashogi death. The Turkish government expected to release details of their investigation sometime tomorrow. Former Soviet leader Macau Gorbachev warning, President Trump not to pull out of a Cold War era, nuclear arms treaty, according to Russia's Interfax news agency. Gorbachev said it would be a mistake for Trump to pull out of the nineteen eighty-seven agreement to eliminate medium range nuclear missiles, suggesting doing so could have unforeseen circumstances. The mega millions jackpot continuing to grow to the largest ever. And so does the number of people hoping to hit all the numbers ABC, Sherry Preston. With.

Shema metro council Nigeria Attorney Macau Gorbachev Senator dick Durbin attorney Saudi Arabia Lampton Trump ABC Eleanor Democrats James Sherry Preston university hospital Jamal kashogi Interfax NBC Turkish government United States
"chima" Discussed on WBAP 820AM

WBAP 820AM

04:26 min | 2 years ago

"chima" Discussed on WBAP 820AM

"For their own actions for whatever the boys choose to do as well and I just, didn't feel like that was An image, of equality and self-determination that we as a district or myself as a mother wanna. Portray equality and self-determination what does that mean That means that if you add like a. A hoochie mama that That There's no fault of yours whatsoever for how you're treated if you act like Is that what it means would this mean for. Leeming in young? Girls you should be able to act like a hoochie. Mama where's short skirt Look. Like a hoot Chima. But not be treated like on that's liberation is that. What we're saying today because? That's not liberation that's being an idiot that's being a fool and that's parents who are not raising. Their daughter properly Man. I don't I don't understand I I. Watched a couple, with, some some of the family members and tow that were teenagers at such a walk in. With a girl in their daughters? In the teenage continues dressed like a hoochie. I could not believe. At a church I was like I you kidding me Are the, parents, not even looking Now yeah I do think that. It's not, all on the girl? I mean isn't that common sense Isn't a common sense that it's not all on the girl hog guy treats, her that like even when? You dress. Appropriately even act appropriately as a as a woman or girl you know what I mean a teenager isn't it true, that no matter no matter how you act and? Dress if you? Act. Accordingly, address, a coordinating accordingly like a woman that you still may. Be mistreated, isn't that true yes Do you have any culpability if you act like dressed like, a woman no woman no it's all the guy? Isn't this common? Sense Are we so culturally lost, that this common? Sense no, longer, makes sense to the average person please please Please tell me we're not that culturally gone that we haven't. Decayed so, much that that folks don't realize that that means that doesn't absolve the man of, any responsibility? Of course they're responsible to if they treat women like an idiot that they're gonna, get, aids Do you want to Dayton idiot within mistreat the girl then you'll get some idiots I mean how's that, the sign that's my side I will say that just like the video, that offended people in Lewisville is in flower mound high school there where they had a video that showed girls violating the. Dress code and being brought in and et cetera and they, played a song about mean girls are bad girls which we've got the. Sun will be could, play it again for you but by the way how many girls know. That song, and like? It probably? Most of them But yeah they should have had a boy video they should've had an idiot boys walk into the hall with the you know the thug jeans and the thug this and the, thug that underwear sticking out and had them. Do the same one for boys yes they should have and yes the Houston school should have, had a sign for boys in the boys locker room that was similar nature I agree with that I do but the. Idea that this is somehow a vial of front to feminism, or two women or that this is these things are untrue is a. Lie in the fact, that they can't do these supposedly that they can't, do these things today And I'll even admit the schools in both cases should apologize say we did not. Do something for the. Boys you, got us but it's the truth we will apologize and to apologize for not doing one for the boys but here's the question if the boy's head if the schools had done something similarly for, the boys would then be offensive to you If the if the schools had the similar type of a sign up in the You know in the in the, boys locker room that would, say you know the more. You act like a gentleman the more shellacked like lady you know something like that and then the local. School district also, had videos that showed boys violating the? Code and stuff like that the dress code would you then be okay with it I would hope so I would hope so Eight hundred two eight eight WBZ. AP is a number.

Leeming School district flower mound high school Chima Lewisville Houston school Dayton
"chima" Discussed on KOMO

KOMO

01:44 min | 2 years ago

"chima" Discussed on KOMO

"You want to make sure that you are on the lookout as well all right so a couple of minutes left in this segment so tell us traveling on the shinkansen super easy it's super comfortable super comfortable and also there's two levels on the past you have the regular pass the green pass okay we got the green pass is that business is it's a little bit higher class but you can reserve your seat now this is important because when we went from osaka to hero chima we had to do a stop the one chin contin that we can go on did not have the preserve seating so without the reserve seating we had to try to get on the train or they ran out of reserve seating we had to get on train so we were with the masses well when you're with the masses there's no seat right so i basically had to stand for about an hour halfway between asaka in hero shema until seven people laugh so if you can pay a little extra i think it's like one hundred bucks more get the green car pass you there's also wi fi in there too and you can plug in and everything like that it's it's it's a little bit more comfortable it's a little easier do you have to make reservations before you go though so you go to the office to say i'm i'm going on these dates and also another tip if you're going from tokyo to anywhere west go on the right side sit on the right side because you might get a view of mount fuji did you yes oh very very very brief yeah because because the mount rainier sometimes it out sometimes it's not out and so when we passed by it so we got a nice view about food because you pass right by it i love those tips have you posted a lotta pictures on your instagram page go ahead in and plug yourself there at yams tv like.

osaka tokyo mount fuji
"chima" Discussed on KQED Radio

KQED Radio

02:55 min | 2 years ago

"chima" Discussed on KQED Radio

"To some of these passages and you hear another worry they say they love the amazon and depend on it and they're aware of the damage being done by industry philippi chima is is heading home to his village in the forest of the guide to manassas for health check he sixty three the shopkeeper says mining's polluting the amazon and things more should be done to protect the river because it's a precious liquid where we bathe in drink respected more music pours out from the bar for why swan all day that songs by banned from the amazon her actually on board starting a local tour for them and others here the river basin is like a road network says wretched now don't you connecting it's towns she does in charge of our boats cargo at ports along the way he picks up crates of produce shrimp watermelons assay berries this big worry is pirates causes as young on in the amazon lots of boats get ready we're arriving to small town called monchy allegedly hocus awaiting on the small crowd of people one guy's wheelbarrow foot of mangoes that he's trying to sell on the boat other people have dried bananas some people have parallel coup fish which they co selling it that's a big fish in the amazon some of these guys have done bother with the gangplank they just climb up the side of the boat and start setting this rivers all about trade from the huge barges loaded soybeans destined for china to any any patricia a mother of three patrizia travels the amazon selling skin cream and vip stick this year's favorite lipstick along the river is among the color of red wine she says the tricia likes going around bhai riverboat up kevorkian's standards because that way she can get to know people demonstrated products there's another woman on board interested leaching people and saddle bag i now my it's necessary to travel to win souls for kingdom of god mommy davos a missionary for the event jellicoe church the church has grown hugely in latin america in recent years it's night again on the middle deck amid the hammocks belva leads a pragmatic groups joined by pastor until you go show.

amazon river basin china patrizia tricia monchy kevorkian
"chima" Discussed on Novel Targets

Novel Targets

03:23 min | 3 years ago

"chima" Discussed on Novel Targets

"But in brisk, we only just starting this the thick rib is is going to be interesting as well as the combination of immune therapy with more targeted agents. But we'll be learning and breast than what we have to learn that we don't just combine things because we can combine them, but that we use rational combinations, for example, mechanism Katiba. This of us drugs that will help us to bring the T-cells better into the tumor and make this Toomas Mon flame third group is going to be interesting in a lot of combinations are just moving forward into the clinic that tried to use small molecules targeted agents to change the biology of the Chima, which will let enable immune checkpoint inhibitors to activate the invitation lymphocytes one of the things that's the topic is liquid biopsies will be able to pick up someone who is doing to progress or acquire resistance for liquid biopsy so liquid biopsy or the analysis of -secutive free chimney is an inch. Tool is a very helpful tool to look for genetic changes that may change over time the challenges for triple negative breast cancer that we lack clearly defined political drivers we contestable if you look at this from an immune therapy point a few one in theory can do Neo engine analysis from sick Lleyton DNA. Although there some technical challenges it comes down to the amount of to derive the relative to the overall delay. But it is theory possible will be able to do at the moment is even if he could do this Chuma to use his as a predictive tool before we start patients on treatment. So for the future. This may be relevant at the moment. The relevance is not there yet, but hopefully could establish more relevance in the next few years when we think about by Mockus going beyond PD L one. What sites you most? I think it has to be a combination of folks today shin signatures. I think that's important in a very simplistic way. We need three to four. Things we need to have immune cells in the tuba or need to get him. Yun cels into the chew the need to be the right immune cells needs to be the right balance of those immune cells, we need to find a way to assess whether active of not city activation status is important and the need to have something to tackle. Which is the tomb aside in terms of mutations. New jen's think if he just focus or two of those parameters we won't be successful. We need to have composite analysis of all those parameters bringing that together because even if you have the most active immune system, but nothing to tackle than the immune system. Bill not be able to make the machine as you said you have to have over different bits of a component. How will we mesh those two actually might determination that we have all of the pieces of the puzzle of jigsaw in place. Good question, and we far away from doing this prospectively at the bay movie. Tune this retrospectively and some of those studies tease elective ation. This is one of the things we looked at in our study, a we still that we have. T- selective? Ation with terrorism of therapy. But the T selective ation itself was linked with response to treatment. So we can measure that phenomenon we know immune checkpoint inhibitors through this very efficiently. But it needs those other parameters to have a tumor response. And at the moment, we are not measuring this in real time with do listen the studies to analyze the data and understand what's going on..

jen Chima Lleyton DNA Neo Yun Bill