28 Burst results for "Cassava"
IGI Researchers Are Using CRISPR to Reduce Cyanide in Cassava
"Like everyone took wrestler guts. Today's episode we're not covering medicine or science communication. It's something different but also equally important will covering chris boden agricultural. So today with us. We have jessica lions and michael gomez and they're going to talk about their work gain casella so when come guys please introduce yourself stewart audience. Hi i'm just. lions staff. scientists. In dan rockstars lab at uc berkeley and the pi of our project at the innovative genomics institute to use crisper to engineer. Cassava without sign wants michael gomez. I'm a postdoctoral scholar in the fast food lab. At the innovative john institute also working jess on cassava and other crops for disease resistance. Thank thanks can you talk a little bit about how you got into this space off. You know either being interested in agriculture and also getting into crisper in agriculture. Now maybe tied with the shirt. I come at this from the end of genomic so i i'd morning on cassava listens twenty twelve and twenty fifteen or something some really interested in using modern genetic approaches to facilitate the improvement of africa crops so As christopher became more of a a more of an option for sava thousand certified segue on into collaborating with golden brian. On using chris burton december. I entered grad school in dozen twelve really strong interest in diseases. How they work how that plays host and at that time crisper urge and it has been a roller coaster. seeing how this technology has been applied. It's been a lot of fun. And i'm excited to apply for disease resistance but also poor consumer safety space.
"cassava" Discussed on Túnel de vento
"A good wear could emerge myspace. He believed def- passage sewage office politics soc who should we also food. Cassava swiss kepi deluge komo father. Oma father grow small musavat away. Mma father dumol swing kit. Keep my from selfies but made a mental model. How this reminded Sewage impure. I get down this short skirt coverage of suicide at pebble abruptly. Org foolish bondue at cowes. Mellish such does. Your schemic is foul. Who scheepers debut. Ge the gimmick will still no showing alzheimer's kush roy abso- advil marvelous. Yet you wrote to produce seem facile vici- pro new bishkek. A tutor consumes newer desk chicago. Scraf our leadership. It's the video mother attachments viable who verse whilst privacy sabah gimmicky mesh knows the thing to spill geeky lequan syrup smuggled yeovil or medium asharq mental conviviality march of frus menu. Kura is loud. Boom affleck's schism humint flexi will not permit the wall may assayed satirical them who cynical star. Simple share masculine end. Who series pure. I'll you mailed yarmysh. Don't kick them both customers. Wounds beijing bowel mile the position yet apoptosis..
"cassava" Discussed on Breaking Biotech
"I thought in the stock around one hundred change and was successful in the face to read our the stocks. I'm massive increase to three hundred bucks. And what i was thinking was that well. This is what the company's valued now and it's just gravy from here. So i hold onto a lotta my shares and what we saw that the excitement around that valuation kinda crumbled and. I think it's mostly due to the fact that capital is needed to do these trials. And there's a big gap in catalysts and nash trials which is what magical is looking at indication in and alzheimer's trials take a really long time and for that reason. There's a big delay. When it comes to getting data that actually instills the current market cap in the stock so what ended up happening with magical is the price fell to around a third of its peak and expect sava to do something similar so i would expect from a peak of around. I'll say ninety that it settles probably at around twenty to thirty dollars a share now depending how much capital they have to raise. This could go up or down whether or not there's a the future is uncertain. But that's what i would expect. Now the callister actually very important as well so what the is looking at for next steps is the initiation of their phase three trial which they say is gonna start in the second half of twenty twenty one what comes from that is perhaps an interim analysis or futility analysis that might be around six months after that so we might be looking at q two q three of twenty twenty two before we actually see data on an official phase three placebo controlled double blind trial there concluding an end of phase two meeting with the fda and they're announcing guidance on that in the first quarter of this year. So we're gonna hear what came of that. I think they're finalizing the minutes right now. And that will provide some insight onto what the fda sees is a path forward for the company and then final open label data. We should expect it..
Has the Reddit brigade found a new target?
"Wines. Have the read it. Traders found a new target guidance. This is certainly an interesting space to target. It is very complicated. it is very technical. And in many instances not very liquid. And it's very binary and there are a number of these names that have huge short interests as to add so it's oil it's all of those are sort of the all the things that i think people on this platform the read it platform would be looking for then. You mentioned cassava so quickly you talked about the volume traded. I think over the last three days today obviously included trade about one hundred and eighty million or show shares. I mean it's just amount of volume over three day period given its historical norm. And you've seen the stock go from about eight dollars a share. I think it traded at one seventeen today and reverse and reverse in a meaningful way. But this isn't just the red it crowd. I mean they actually had data come out a couple of days ago in terms of the alzheimer study. There was pretty positive. I think that field this as well. The concern i would have here and i'm not endorsing. I'm i'm not making procon statement of any of these names. We're going to talk about. But they did a secondary back in november from that mistake in november thirteenth. About eight million or nine million shares secondary around eight dollars a share. Be aware that for a lot of these companies given the stock price move. This is an opportunity for these companies to do secondaries. I would imagine you'll see one here in another name that you didn't mention but is a big enough market cap that talk about not necessarily a biotech company but falls under those parameters as named like vera site which is at another ridiculous move. You can pull that one up as well. i think. it's v. C. y. t. If i'm not mistaken and there's talk that maybe a secondary might becoming there so just be aware that a lot of these stocks have had tremendous runs but you know secondaries are looming out there. Potentially you can obviously see what could happen to the stocks in the midst of one very binary a lot of these names. Just be aware of what. You're getting yourself into again quickly. The way to play this all along the slow and steady ways been the. Yeah brian kelly. What do you make of this
GameStop shares plunge more than 40% as investors bail
"Gamestop shares down for a third day and four falling 37% as retail traders flocked to other corners of the stock market, such as small drug developers. Among some of those names and Avonex up more than 50%. Cassava. Science is down 22%. Mankind shares tumbling now by about 2%,
How 'Bout Dem Apple Seeds
"Okay thomas we are talking about apple's today. Why don't you tell our listeners. Even got started down this weird little apple path so a few weeks ago i saw video of a dude eating apple from the bottom. And you know. I it up to the pitch me and at the time all i wanted to find out from the team was whom amongst us was with me in eating the entire. It was just way to start to get the conversation going. Yeah i remember. And i was horrified to find out so many members of our team eat the whole apple. We were pretty divided down the middle. Yeah that's right and the discussion led to the possible dangers of eating the apple seeds. Some of us had heard they might be toxic. Some of us hadn't so here we are chatting away about them apples and the science behind whether or not you can eat the core why we are here. Today is pretty cool. Yeah totally and i found a food. Scientists to help explain it all could also My name is islami outs. For last shoddy. I am senior lecturer in the department of food. Science outsider jackets ally investment technology. Islamia is a few scientists beast in nigeria and she told me on the one hand apples. Are these magical fruits. That are really nutritious. And good for you apple's Poplar fruits us are reaching nutrients such as anti oxidants minera house vitamese dietary fiber is an auditor nutrients but their seats are different than their flesh. Yeah exactly what i'd always heard. Is that apple. Seeds have like some amount of cyanide in them you know like generally not something that is good for humans i mean yes and no i asked islam yacht to explain it and it's a little more complicated seeds that is in the center of harpool copy above causing poisoning because the seed contains it compounds. That is called. I mean. I lean mick. Dolan is a compound that's found and lots of natural plants and things that humans eat such as apples but also peaches apricots and almonds. They're is a similar compound and cassava he staple in nigeria and on its own mattie in seeds a midland is usually harmless to people no concerns there but what is potentially concerning is when digestive enzymes in our bodies come in contact with the michelin and when they combine the enzyme breaks away the sugars in the dylan and leaves cyanide which could potentially lead to cyanide poisoning. What do you mean. Potentially thomas say more. Well the conditions have to be just right mattie for this to be more of a concern for starters the midland in apple seeds is encased by pretty tough outer layer in order to expose them make the land to our digestive enzymes have to chew those seeds really really. Well okay i get it and even whole eating monsters like you. Thomas are generally crushing those seeds down to a fine pace with your teeth right exactly. Mattie as much as i love that tidal more importantly though there's not enough apple seeds in one or two apples to really show in effect on our bodies the amount of cyanide that does get formed if at all our livers are pretty good at filtering out those hawks
"cassava" Discussed on ExtraTime
"Were they hard done absolutely. Not if they were the. They made themselves their own worst enemy. Where if you tell me that they put that same energy towards a productive. Second half where they had keep everybody on the pitch which is a huge question. I mean you almost felt like every orlando match going into the match. The chances of them going going leaving the match with eleven men was low. Like that's just how revved up. They were and what they needed more than anything was somebody to say. Hey calm down as red card. It's a rash challenge. Let's move on. Let's go forward with the ball. And you know who you're i'm looking to in that position. Oh european champion You know Champions league champion noni he and he was the one of anyone that was going the most crazy but changes jacked up from the first half. He's but he's raised that way right and this is exactly what i'm talking about being on that hedge and being on that line because there are times where we've seen in almost back where he's willing his teammates on and channeling into a really productive way and he's a fighter and he wants everyone to bring the same but there are times where that experience. I just kept waiting for that experience to come. And someone's be like. Hey where in this were down to one. We're at home. We're in the heat. We've got the second half owing less. Push on and find a moment to win and that moment just never came and they orlando consistently in the playoffs for their own worst enemy and showed some inexperience In the wrong time. And when you're going against side you just felt like okay. Cassava szabo's going to hurt you at the end and just ice this match that ended up happening and that was it. But i just can't help. But i wanted to see orlando continue with everybody because i felt like they could. They could have gotten not only the equalizer but but potentially the winner. I think this team is good enough to do that. A. bring on the depth visas and they just never gave themselves a chance. Benign misses a pico to. I'd just the right way to say matt. Turner saves ninety. Pk but that. That was an opportunity to go back to two didn't happen another one forum and once was saved it was over like even 'cause they went man down then they drew the penalty. One fat bogged saved. I don't think orlando had another opportunity. Everyone knew that was your shot. That was your opportune. They weren't going to get back in it and to kaelin point. It's a little upsetting. I would even say though..
Severless: Improving How We Serve up Websites and Applications With Jerome Hardaway
"cassava" Discussed on WGN Radio
"There's a ton of things out there where you could be doing that in five minutes. Now, you might not be as protected as you should. But you, you, khun doir it and give you a basic that absolutely and in the cases of mostly commercial applications, I don't care if you're mak er or Windows or Lennox, it doesn't matter. Accomodate anything we're talking to Jason Glassberg and ethical hacker. Don't you know he's the co founder of Cassava security. You can go to cassava dot com and read all about it. I'm Riley James. You can join us 88 8765593 88 88 Rally on wg and radio. We're talking to Jason Glassberg and ethical hacker with cassava security. Kasaba dot com. And I I want a second. What you said earlier about credit cards. I don't think it could be said enough. It's Ah, It's the government's gift to us. In terms of protection. You have so many protections when things go bad with it with a credit card that you do not have with a debit card or any ATM material, and it's amazing to me that people don't use it for everything. I go into 7 11 is a big gulp. Here's my 79 cents here. Here's the MX. It doesn't matter to me, but ah, it's it's It's true, Jason. It's probably the biggest gift to our security we've got and it's amazing to me how many people don't realize it. It's amazing to me how many people don't take advantage of that. And how many people don't really check their statements carefully enough to see when issues arise with their credit cards. So a lot of you know, I guess you know it's not for me to judge people's way of dealing with finances, but I know I'm always looking at my bill. Like a hot Yeah, only because you can never be too sure. Right. But you know, that explains something. I'm always amazed when they say, Do you want a receipt? Well, hell, yes. I want a receipt. I want to compare it to the statement when it comes in. Yeah, but, Yeah, yeah. You know, I've actually I mean, I've gone so far is have a credit card. Used specifically for online, you know, absolutely is the easiest way to train my purchases. I have no family. I have four kids, right? Everyone needs something. If I don't. If those charges somehow get co mingled with everyday charges, I'd lose up right? No, no, I'm going to have my own sense of a card, right right and pick one those cash back cards that will give you 5% for online shopping. Right. And maybe go with one of those cards that double the warranty period. Yeah, you buy. Yeah, exactly. You know again. It's like everything else in life. Do a little research first on you always benefit from smart. Yeah. Now I got an email from Don and he and he could have called that's 8888765593. And he said, Well, I don't want to be in the cloud. So if I'm going to be backing up and it can't be on my land, how do I do that? No, I'm really old school. I just say, well, back it up and pull the plug, but they're an easier way. Well, yeah, I mean, there is first of all, the first thing I would say is that I love the cloud right, because to my mind that Microsoft's in the Googles and the M E and the Amazon Have based a billion dollar business on having these infrastructures D secure. And I will always trust their equipment over anything I could put together in my vacation for, you know, dining room. So I would say backing up to the clouds are using one of these professional online services to backup is always a good idea. Of course, you're only going to back up what you tell them to back up, so you know, you need to make sure you're doing a proper kind of backup. Now that being said people might be uncomfortable with putting sensitive information up in the clouds. Of course, you can encrypt it, which is basically scrambling it putting a password. Tonight. No. One If they haven't even got your backup would be able to undo it without a password. There are still older school ways of doing backups. I myself do multiple kinds of backup. USB drives now are very cheap. You can get multiple 100 gigabyte drive under $100. Absolutely one in back up my documents over once a week once every couple of days. Put that disc on this show. Call it good. I do that with two or three different on that way, I revolved the backup, so I've never relying on one particular piece of hardware. That's one way of doing it not online and relatively inexpensive. Yeah, it is an expensive and it's not difficult to do. And it's also not difficult to remember. Especially if you're aware of what happens when you don't Now. Well, that's just it. You know, it's one of these things here will be awfully sorry just until you can, even depending on what your level of data requirements are back up your most important documents to a 64 gigabyte USB key, which is under 10 boxes. Now with with Mac, that's so lovely it all. It'll automatically just back up everything and restore your hard drive. I haven't found a similar application for PCs. That really works of you. No, not they have the time machine back up to the back. Alright is wondering. Yes, Yes, absolutely fantastic. There. There really isn't But again, you know, I keep everything in a holder, a document holder, So just moving that folder over to Ah, hard drive. Is relatively simple. So I agreed. Time machine fabulous. Back of invention. Don't demand E. I don't necessarily need it when I'm on the Windows machine. Yeah, I don't understand why Windows hasn't come up with time machine because I'm sort of a mixed network. Well, Mac PC some Lennox, But my max, nothing backs up like my max And I say to myself No. Come on, has been a wild time machine's been out there. How is it that PCs don't offer this? Yeah, I don't know. I mean, there's a lot of third party software that built the OS level like that. They're not in it, And that's just about everything Apple When you come to it, Look, they make the hardware. They make the software. It all works because there's no third party right now that you know you pay for that because you're going to pay much more for a comparable PC, but the level of convenience certainly. Yeah, it'll be interesting. They're going away from intel, as you know, And I'll be curious to see how that goes. And of course, I'm pain. Well, you remember when they over from power PC to intelligence, the same, you know, to share. This clearly states But then they did pretty well. One thing I would not do is sell apples short in the ability to implement their own hardware. Well, I just I just pray that they will continue to care about Osx because the world is such an IOS world now and that that's somewhat drives me crazy, But you mentioned power PCs. I've still got some A few of them because, you know, cos they're now out of business like the people who made peek. Ah, you can't run Amman, intel, So it's like, I don't want to get a peek entirely. You know that that kind of thing, so ah, eventually, of course, going on. That's you know, that's the problem was kind of, you know, related something we had talked about earlier with.
"cassava" Discussed on Breaking Biotech
"So for that reason, I think it's a by I think will probably do well in the stock but again, none of this that I'm getting right now investment advice this is all for entertainment purposes. So please do your due diligence if you're GONNA look into buying this company and that's all I got for bt I but in the next little while right now, what's going on the Democratic National Committee and I think next week is the Republican National Committee so. Be Aware that the concerns about election stuff is probably gonNA start to hit the stock market I think the FBI continues to waver between like one twenty, one ten. But as we know, both parties have been pretty uncharitable when it comes to the biotech sector and even though a lot of the vaccine companies have been propping up, the expert is a whole. I think some concerns over maybe A. Democrat win or maybe just uncertainty in the election outcome which we keep hearing more and more about could lead to some negative pressure on the experts in the market in general. So I'm a little bit nervous about that but that's pretty much the only thing I'm watching for other stuff is the Koga vaccines we we might see more date in the next little while so is out on that. In terms of a portfolio wrap up this is based off of Friday last Friday. So it's definitely dated but just some stuff I wanted to bring up is that I sold Trevino at three dollars and nineteen cents the profit from that as tutor ninety bucks but. Thing I want to point you to is the. Profit loss was two hundred and seventy nine percents very excited about that. Even though I only gained a meagre three hundred bucks in the stock but still happy to see a win there and I've not put ti in here just yet. But I mentioned on twitter that took a position in my average is around forty one and change. Overall. I'm sitting at around negative nine percent year to date, and that pales in comparison to all the other exchanges. But like I keep mentioning the back half of this year is my time to shine. So I think things are going to turn around by the end of the year and we've got a lot of exciting stuff coming up in Q. Four. So I'm looking forward to getting into all the interesting data that we see. Beasley I'm going to wrap it up there guys. So I want to thank everybody for watching. Hit the subscribe button. If you're feeling generous, please leave me donation using the tip link in the description below and if you wanNA share show that would also be awesome. Thanks everybody and we'll see you next time..
"cassava" Discussed on Breaking Biotech
"But they got it wrong and the journalists who have not going to name. They erroneously wrote that eight patients were hospitalized following severe reactions to the vaccine. And unfortunately, that just wasn't true. So there were some adverse events that happened just like any other drug, but they weren't as severe to merit hospitalization and unfortunately the good people at stat news the editors weren't able to catch this and the stock price I think the the trough and the high the differences around fifty dollars. So people had stops in places. There's a good chance that they all of their stock when it crashed on this news of the potential hospitalization. So you know I've. Given some commentary on Stan us in the past. But for me I, just don't see them as being very reliable news source I hate to say the word fake news but here they were a real culprit of fake news. So I encourage everybody to be careful and this is something even if you don't follow Stat News, they affected the stock price such that you could have lost a lot of money. So everybody be careful out there and even with stops you could get burned pretty bad. So that's Novak's. The next thing I want to talk about is t g therapeutics ticker symbol TJ, x they're trading at around two point eight. I think it's higher than this billion market cap rate now. And the news that we heard is the FDA accepted the new drug application for umbrellas as a treatment for patients with previously treated marginal zone lymphoma received at least one prior anti CD twenty base regimen end funicular lymphoma who received at least two prior systemic therapies. So this isn't really a surprise we would expect the FDA to accept their application, but the fact that they filed it in everything's looking good is a good thing. The other piece of news that we heard is that the marginal zone lymphoma indication has accepted for Priority Review and now has a pdf data February fifteenth in twenty twenty one. Meanwhile, the FAA date for the full foam indication is June fifteenth twenty, twenty one. So now he had very concrete dates on when these therapies could be approved and then marketed, and then t GTS can finally search revenue since up to now I think they're not really able to do that. So the some excitement around that other stuff going on they announced their Q two earnings report, and we saw that they lost a net amount of fifty two point, nine, million dollars and their cash and cash equivalents is two hundred and seventy, five, point, six million, and this is supposedly going to be good until the end of twenty twenty one. But as we know companies tend to stretch the truth when they talk about their cash runway. For me though I'm holding onto a decent position because of the next major catalyst is coming up in Q. Four of this year, and this is the face three ultimate one and two trials, and this is for an M. S. indication, and if they're able to see positive data here, I could see a big upside in the stock. The market size of multiple sclerosis is very large, and if t GTS can see better data here than say traditional therapies. I think that they could become kind of a leader in the space to some capacity and given that I. Think It's worth taking a position here and I think my average now is like eighteen or nineteen, but I still feel pretty good about it and we should see the readout coming out soon. So. That's Gt and then the last company WanNa talk about before we get to our major story today is cassava scientists and they're trading at around eighty four point two million dollars as a market cabinet,.
Biotech Pipeline Updates
"We're in the middle of the cove in nineteen pandemic is continuing the escalate in California here. We're doing okay. The shelter in place seems to be Instituted in personally in San Diego we've seen the beaches and parks officially closed so that continues to escalate. But you know I'm doing okay out here things. Aren't that bad. As of now the situation does seem to be getting worse. And we're GONNA talk about that a little bit and I also want to talk about a few pipeline updates that we heard from some pretty cool company. So let's start with that and the first company wants to talk about is cassava sciences ticker symbol. Save A for those. Who Don't know but I did do a video on them. Maybe three or four years ago maybe two months and were waiting for their face to be dated. Come Out and this is a twenty eight day trial with their drug. Pti One to five. That is supposed to change the course of the disease in Alzheimer's patients so will we heard a pipeline update and their CEO said that their clinical program show no signs of slowing down. This is good. I think a lot of people weren't concerned in general all biotech virus. It really does get out of hand and trying about SARS cove to it could really interfere with regular clinical trials. Say Half the patients get the virus and have to undergo treatment for flu. That's not ideal when you're trying to just look at eight control and test groups so anyway related to cassava. Apparently their clinical programs are not slowing down and their fees to be trial completed patient enrollment as well as dosing and this is as a march twenty twenty and they mentioned that there were no safety issues found a good thing and then they also said that the company expects to announce top line results approximately mid year twenty twenty and then they also announced that they're going to initiate a one year open label study of the drug. So if this happens to not work out you know. There is a chance that the drug could affect patients in one year's time in case the Twentieth Day treatment isn't quite enough so the details of the trial. Definitely check out my older video on that. I I took a position in the fives that believe in. I think the companies now trading in the threes so I might add a little bit to the position because I did only start scaling in and really looking forward to seeing this readout here in mid twenty twenty because if it is positive the stock it increased substantially so. That's what I'm betting on here. So let's move on. Dvd TECHNOLOGY TICKER SYMBOL DVD. There a allergy company that is kind of competitor to immune even though some people would not consider them necessarily competitors because one obviously is much less effective than the other so the issue with DVD. Tea Is that their skin patch vice skin product. It is less effective than amiens. Oral immunotherapy of the benefit of that is that there are significantly fewer side effects but the issue is the FDA really wants to see that there is efficacy benefit to patients taking this drug or this therapy in order to improve the product. So we saw that Amien got FDA APPROVAL. Finally and that was nice to see and the concerns. There were that the product does have some side effects associated with it. D- On the other hand does not have many side effects but they do happen to have a lack of advocacy so what happened is the FDA identified questions regarding the efficacy of its biologics license application for vice skin peanut in patients with peanut allergy as a result the allergenic. Products Advisory Committee a PAC meeting to discuss. The bialy will no longer take place as previously scheduled so this led to a big drop in the stock and DVD's struggled off and on dealing with the FDA that's manufacturing issues last year. Maybe year more than that. I don't quite remember but I am concerned. This and I don't think it's worth buying the dip. Necessarily if they're able to show efficacy. It's going to be a real problem now. They do have some data coming out soon. That could show. That product does have more efficacy than their other. Trials showed. So if you're looking for a high risk play could do that. I am interested in space. This oral or skin related allergy desensitization. Keeping my both companies and they have taken a big hit in this recent downturn. We've had someone beekeeping my out on them all right. The next company I want to touch on is Viking Therapeutics. And it's been a long time since I talked about them. They are a company that has been Kinda slow too bad but they might have the best in class drug for Nash. It's a thyroid. Receptor Beta agonists. That does really well in lowering liver fat. So the news that we got is that their board is authorized a stock repurchase program whereby the company can repurchase up to fifty million dollars in stock over two years and this came as the market was really coming down. And I'm Kinda surprised because oftentimes these small biotech companies really struggled to raise cash because stock prices so depressed as it's being sold off for some reason. Viking has decided that it's more important for them to kind of artificially increase the stock price by doing a share buyback so as of December twentieth nineteen. They had two hundred fifty seven point six million dollars in cash. They are presenting data from their twenty eighteen trials at conferences which seems like kind of a waste of resources to me and we've really seen the data digested. I don't know what they think they're gonNA get by presenting that data. It's one thing to kind of present the updated data. But we don't really have much of that so for me. This is kind of a strange move and I would much rather than us that fifty million dollars towards anything else that would either increase the likelihood of their pipeline candidates being developed. Or you know hiring people that are good at developing Nash candidates but instead they're just buying back stock so this is not a very encouraging. Move to me. We're we're still in the midst of this case to be trial and we're waiting for that data but one thing. I wanted to notice that I looked at the clinical trials dot gov symbol for for their trial and it looks like the primary outcome is actually twelve week. Mri Data and analyzing liber fat content. The trial started in November twenty nineteen. So this actually a chance that we could see this data in the next six months or so at least before the under twenty twenty. So I'm Kinda keep in mind that and for that reason. I'm not selling any of the Stock. I have even taken quite a hit in the position. The secondary endpoint for this trial is fifty two week resolution of CFO hepatitis. The histology that's the actual biopsy of liver where they're actually going to be able to score it and evaluate. You know whether or not Nash has been resolved to some capacity given the metrics that the FDA wants them to look at but the endpoint. We're going to see. Is this twelve week. Mri data deliver fat content. And we can be pretty confident. That liver fat is going to go down. The patients in this trial are biopsy confirmed. Nash patients so the Bar is raised a little bit higher than their face to a trial. That was just done using. Nfl D. patients which is a milder form. Before you get to Nash Fatty Liver Disease Problems. So that's where Viking the last company. I WanNa talk to you before we get to. Our highlighted story is excellent therapeutics and we heard that they are accelerating the trial completion for a excess zero five typo there in Alzheimer's Disease Agitation to Q. Two rather than Q. Three Twenty Twenty. I hadn't really talked about the disease agitation trial because I think it's their lesser important one. I'm much more excited about the treatment resistant. Depression read out. That should be happening in the next week or so. And there's also going to be read out for x zero seven in migraine. Those are going to be really big moves for the stock and now we can just add another one in Q. Two we're going to see this Alzheimer's Disease Agitation. Xm Is the ticket for axiom. It's been all over the place throughout this whole downturn in the market and I have taken another position or a kind of double down with what I had because I kind of bought it at the top but I do think that they have a good chance of seeing a positive outlook in t already resistant depression and if it is positive. I think it'll be a big mover for the stock because physicians really struggled to treat already so this would be huge for them. So that's kind of where we're at with axiom and I'm looking forward to the date in the next little
"cassava" Discussed on Breaking Biotech
"What's up everybody? Welcome break in biotech. Thank you for being with me here today. My name is Matt and you like the Channel. You can help it out. By clicking the like or subscribe button you can also help out the channel by leaving a review. Wherever you listen to this podcast. So I'm glad to be back and thanks again. Everybody I really do appreciate support. I've been getting the numbers have been growing quite substantially lately. So please continue to tell friend today. We're going to talk about cassava sciences and Alzheimer's Disease Cassava. Themselves are quite a small company. But they've seen a pretty substantial increase in valuation lately so we're GONNA touch on their pre clinical data the face to a data. They released late last fall. And then we're going to move on to my suspicions for the upcoming data released that they're going to have. And then we're GONNA finish up with a twenty nineteen recap and then a portfolio review for the last week. So that's the plan for today and with that let's just get right into it. So Cassava Sciences Ticker Symbol S. A. V. A. They closed on Friday the tenth of January eight dollars and fifteen cents a share giving them evaluation of one hundred and forty million dollars and like I said I think it was about a month ago. They were trading about one dollar in change so they have increased quite a bit lately but I think there is some good justification for that. But we'll talk about that a little bit later. The companies formerly known as pain Therapeutics Ticker P. T. i. e. and they were trying to develop a drug called Moxie which is an extended release oxycodone and they were developing this as a means to deter abuse in patients but they ran into a lot of trouble with the FDA just not seeing eye to eye on how this drug would be beneficial to patient so the company ended up dropping development of the drug. They rebranded themselves as a neuroscience company with a focus on Alzheimer's disease so the company in their pipeline have a single molecule as well as a diagnostic test related to Alzheimer's disease. But in this talk today. I'm just going to talk about their molecule and its potential in Alzheimer's disease but before we get into that we first need to touch on Alzheimer's disease and so for those who don't know Alzheimer's is a chronic nerve degenerative disease symptoms of the disease include things like disorientation language problems mood swings of motivation as well as behavioral issues the risk factors so this disease. Because we don't really know what causes it. They include things like family history history of head injuries. Depression hypertension. So it's all this conglomerate of things that we don't know why they contribute to it but we do know that they do one of the issues with Alzheimer's diagnosis is often delayed. Because the symptoms are mistaken for normal aging. We know that the disease mechanism is not understood. Very well I touched on this and other video so put a playlist together for everybody who wants to look at that. I've talked a lot about Baijian in their attempt to effect Alzheimer's by modifying Amyloid Beta. And how that hasn't worked out very well but for our purposes today. This is interesting because it's a different mechanism. So we know that amyloid Beta is able to bind to receptors on neurons. And somehow this leads to hyper phosphorylation of Tau and what we're GonNa see later is that you can alter this relationship through chemical means and this might lead to an improvement in the disease. So we're GONNA touch on that but there are multiple different hypotheses around how Alzheimer's develops and we still don't really know. What the primary mechanism is the treatments. That exist today. Don't alter the course of the disease. But they do effect this symptoms that are present so dinette. Brazil which has been approved for a long time isn't a CDL as inhibitor. And that seems to prevent a lot of the negative effects of Alzheimer's other treatments that have been around for a little while now. Amanda Dean and maintain our an MD a receptor antagonists and these also seem to help patients as well. Now when it comes to the size of the market of Alzheimer's currently twenty six point six million people worldwide. They're diagnosed five. Point eight million people here in the USA and this number seems to be increasing as the demographics are such that. The baby boomers are now in that age where it's more common to get diagnosed with Alzheimer's disease. I have here on the right. An estimate of the revenue that's been generated from previously approved Alzheimer's drugs. The one of most notable importance is air set and that reached a peak of three point. Five billion dollars in sales and that was in two thousand nine and two thousand ten. The sum of all four of these drugs in the revenue was six point. Five billion dollars in two thousand nine. So there's obviously a huge market potential here for a disease modifying drug and another thing. We need to consider that a drug that can change the course of the disease. Mike Garner premium even more than what was charged by the company that developed air said. So let's talk about cassava scientists main molecule. Which IS P T? I one to five. And this is a drug. That's able to bind to a protein called a when it's in a special confirmation and I'll talk about that in a second. But the role filament a is to act as a scaffold protein and this is a very important function because often proteins are just hanging around in. The site is all randomly and they need to be brought together in order to mediate. The deduction of a signal so filming is one of various different scaffold. Proteins IN THE CELL. And it's been characterized as bringing ninety different proteins together to mediate the function of a signal through a cell. And I know it's very broad but you think about all the different pathways. The different ways that cells can communicate through these means so film and just one version of that and the hypothesis is that amyloid Beta outside of the cell binds to the Alpha seven NICOTINIC acetylcholine receptor. And when it does this recruits filming a on the inside of the cell altering its confirmation in mediating dysfunctional signaling one of the consequences of this pathway. Here through amyloid. Beta and this Alpha seven nicotinic receptor is that it leads to hyper phosphorylation of Tau. So this is how we go back to the amyloid hypothesis and the Tau Hypothesis. That apparently through this relationship amyloid Beta is able to affect hyper phosphorylation of Tau and lead to the deleterious effects associated with amyloid Beta. Now what does is it binds to fill them in a when it's in that confirmation that's enabled by the binding of amyloid. Beta to the Alpha seven nicotinic receptor and when P. T? I BINDS TO FILM IN. A it's able to fix. Its confirmation such that there is no dysfunctional signaling and it prevents Tau phosphorylation. There's another mechanism that involves CD fourteen. The toll like receptor four and neuro inflammation. But I'm not gonNA talk about that. The ability of one to five to effect this amyloid Beta hyper phosphorylation of Tau is probably the primary mechanism in which it has any effect at all. So that's the premise. On which the company has developed this drug further. And I'll talk about a little bit of evidence that suggests that this is true so I'm showing here some Western blot data from the lab. That developed this drug. And what they did here is they took human hippocampus. They treat it with amyloid. Beta with or without. Pti One to five for a certain amount of time and what they saw was when they treated the hippocampus with amyloid Beta. We see this big increase in Tau phosphorylation which you can see here and for those just listening to take my word for it but then when they treat it as well with PT. I one to five. We see dose dependent decrease in the amount of phosphorylation and nitro cessation of town. So this suggests that P t two five is able to disturb that relationship between amyloid. Beta the office seven nicotinic receptor and phosphorylation of Tau thus hopefully preventing Alzheimer's disease and some of the cognition effects that are associated with that. So this was just done in vitro now I WANNA move to the face to a data that they showed in late fall last year. And we'll see whether or not there was an effect in actual living humans. So the first thing they did was Pharmacokinetics looked at how the drug behaves when it's placed into humans and this drug is taken Twice daily one hundred milligram doses and what they saw here. I mean at least for pharmacokinetics. You're looking for whether or not the drug is able to stay in somebody's system for certain amount of time. You want to make sure that it is in fact absorbed in that there is an appropriate dosing schedule that can exist if there was any accumulation of the drug that occurred between day one and day. Twenty eight and that didn't seem to be the case the drug seems to behave similarly whether they're being dosed on the first day or on. Day Twenty Eight. So that's good to see we'll see that the half life is still around twelve hours either way so this dosing schedule suggests that the drug is around and if it will have an effect it should have that effect given these parameters. They're only looking here when it comes to the biomarker data at a change from baseline today twenty eight. And I'm GonNa talk about this timeline later because I think it's relevant when we get to the cognition effects that we're looking forward to seeing in the face to data but basically here what we see is the levels of Tau levels of a Beta Neuro. Filmon light chain neuro granted as well as this protein Y. K. L. Forty. And what we see across the board except for a Beta is that in the CSF as well as the plasma. There's a pretty substantial decrease in the levels of these proteins. We see that in a Beta. There's an increase in CSF as well as the plasma and it's a little bit of a strange correlation but actually an increase in the level of CSF a Beta correlates to a decrease inside of cells or inside the interstitial space. So that's actually a beneficial thing to see if you look at the individual patients here. It makes it a little easier to see the data but pretty much across the board. Every patient responded relatively well. There's two patients in the Beta frame where we see that in fact there. Csf A Beta decreased which is not a good thing that means that there's increasing amounts of a Beta inside the cells inside the interstitial space to look at the data data on its own. I'M GONNA blow this up a little bit and we can see here that except for those two patients everybody else increase the levels of a Beta in the CSF which is a beneficial thing. If you're trying to lower Alzheimer's disease looking at plasma biomarkers so the same thing but just instead of cf they looked in plasma and it was a little more mixed but in general the trend was going in the right direction. Not GonNA spend too much more time on that. And they also saw that plasma a Beta increased and I think that this relationship is less tenuous than the CSF relationship the levels of Beta inside the cell but this does go in the proper direction they also looked at cytokines given the effects of PT are one to five on neuro inflammation and these didn't see a very huge effect but did kind of go in the right direction. So that's also good to see and then they also showed this western blot data and what they were looking at specifically is in plasma. They wanted to see whether or not Tau phosphorylation or nitrous. Latian was decreased after dosing now. Western blot is not a very quantifiable way to look at these things but it does give us some insight into it but to add to take with a grain of salt since I personally did a lot of work using this technique in my in my past life but basically my issue with it especially with plasma samples is that it's tough to normalize because you need to make sure that the amount you put in is compared to a standard and hear what they used as their standard is tau when it came.
Iran expert: U.S. airstrike was "stunningly stupid and counterproductive"
"Amid rising tensions and uncertainty as to what will happen next after the U. S. killed an Iranian general there's growing fear that some sort of retaliation could be happening against the US comes call Miller reports many experts believe it could come in the form of a cyber attack on a convoy up in flames and in the daylight the aftermath of that deadly airstrike ordered by president trump in Baghdad top Iranian military official Qasem Soleimani killed in that blast thousands taking to the streets in Tehran to mourn him I am concerned that Iran will have to respond in some way ray shot cassava leads the Jackson school of International Studies at you job and I don't expect them to go out really retaliate in a major way Deadpool lead to an all out war because that's something that the Iran can't win but something they are good at he says is carrying out widespread attacks using technology attacks that could cause real how the heck do you do have other capabilities including cyber for using proxies in different parts of the Middle East going after American civilians and companies if you call system already in business is the owner of a radiant grocery store tells me that many people in the community are afraid to speak out at all about what's going on right now in the
"cassava" Discussed on KIRO Radio 97.3 FM
"Cassava molasses is incredibly delicious and then also you know expanding on the repertoire of you know Thai dishes that we have so instead of just offering like I pad Thai recipe and I'm you know things of that nature I would you know we have we now that house or a which is great this time of year actually it's one of my favorite cold weather dishes what do you mean how do you make that it's it well it's just a it's a braised bone in chicken curry it's got kind of it's a little it's not quite as heavy on the cooking at mail because a lot of of some of the cars that were used to but it's also not like a quote unquote jungle curry that's just Prof so you know it's kind of in between I have brought that has a you know some influence from from the you know kind of a Chinese influence because of it it's a northern Thai dish but it also has a tumor can it and of course egg noodles and then it's topped with a fried egg noodle topping so you get it's like noodles Biggles two ways it's delicious I love that and we were also kind of expanding on a lot of American classics that were not covered in previous editions so things like Chicago style deep dish pizza strawberry soccer which is like a regional North Carolina and desserts kind of like a cobbler Appalachian apple stack cake batter cakes with St Louis specialty which you know I do we were really scratching our heads on that one because obviously arm is from Saint Louis and select I guess it maybe she just had and didn't like it but it's absolutely delicious uhhuh so it never made the book in one from her purse and I have the same now interesting the I would you know that is such a celebration of local cuisine over the last fifty years compared to what I've what do I know about fifty years before that I'm a youngster but but it's it is it is interesting to go back and celebrate those dishes when you talk about all these other things like the Thai food stuff it will really wasn't twenty years you could even go that you couldn't get those ingredients right or you would have to go to a specialty store owner yeah I find some other source for them but now they're so ubiquitous and I think people's pallets have also changed over the past twenty five years I think people are just.
Climate Summit Special: Some States rise to Guterres challenge
"This is all wrong. I shouldn't be here. I should be back in school on the other side of the ocean yet. You all come to US young people for hope. How dare you you have stolen my dreams in my I childhood with your empty words yet. I'm one of the lucky once people are suffering. People are dying buying entire ecosystems collapsing. We are in the beginning of a mass extinction and all you can talk about is as a money of each economic growth. How Daddy you Greta Thunberg. They're the young climate activists who ignited a global movement of youth refusing to back down on the climate crisis and now at U N headquarters in New York she she sits face to face with the world leaders her and fellow youth have been demanding action from my message is that we'll be watching you delivering an emotional speech on political action and the fate of our planet she kicked off the UN's first ever full on climate summit today today at the top of the seventy fourth general assembly debates welcome to the lead is on a climate summit special. I'm Natalie Hutchison and next up you'll hear some highlights highlights from the Climate Action Summit where innovators heads of state and other international organizations from various regions of the world have showed up with answers to the secretary-general's general's constant plea for concrete plans on how to combat this global crisis of our time. UN chief into a new parish has been steadfast in his expectations nations for the summit the first of its kind repeatedly urging members to do without grand speeches and instead bring their clear actions on how to build a safer cleaner planet. Senate nearing four years since the world decided on the collective response to lower carbon emissions the two thousand fifteen Paris climate accord member states brought answers to the stage on Monday from the science to the funding representatives explained just how they've committed to greening their cities and implementing sustainable strategies for ensuring their efforts. Don't go to waste from the beginning. I said the ticket to entry is not a beautiful speech but concrete concrete action and you are here with commitments in the lead segment on carbon neutrality. Here's U. N. special envoy for Climate Action Mr it Michael Bloomberg the most important thing that we can do is to phase out coal as fast as possible and we are making progress since we I started beyond coal in two thousand and eleven more than half of the United States is coal plants have closed two hundred ninety seven out of five one hundred and thirty a growing number of US cities and states and businesses have committed to reaching net zero emissions these states would by themselves selves form the world's fourth largest economy next on the stage French President Emmanuel Macron on Climate Finance folks will take on its responsibilities disabilities. We have already ended any new oil exploration on French soil now the second part of this positive agenda. I think we need to have a trade agenda. That serves the climate. It's a gender when we trading. We have to be consistent. I don't want to see new trade. Negotiations Open with countries Tris who running counter to the Paris agreement I think that that would be deeply hypocritical given all of the debates that we continue to have today and also in previous days. We need to have a carbon neutral chill. Europe and we need to have zero imported deforestation. This is essential. This is a deep change. It is a real revolution and it doesn't mean the we don't import certain things but the any imports should have a negative consequence we if there there is a negative consequence in terms of deforestation for example that has to be compensated for if not we'll continue to have fine words but trade agenda that runs counter to those words and on the link between coal phase out and Human Health Executive Director of Clean Air Fund Miss Jane Burston Appalachian Kills Seven million people every year and many millions more Safa with chronic conditions that caused or exacerbated by pollution. I want you to imagine the schoolgirl gulping on the road side because of an asthma attack Broughton by air pollution the causes of climate change of very often the same as the causes of Appalachian Burning Fossil fuels like coal is one of them. It contributes two-thirds of outdoor. Oh Appalachian the deletion staffel can also be the same renewable energy electric mobility more walking and cycling to name just a few and an economic terms the and the World Bank calculate that tackling Appalachian will actually save US money trillions a year so I urge the leaders gathered here today to respond to the World Health Organization's call to action and to put tackling Appalachian at the top of your agenda agenda because cleaner is a human right and together. We can make it a human reality. Thank you the turning it over to Costa Rica. The good news is what I thought of this good afternoon secretary-general Excellencies. It is possible for country to support its economy with trysofi coming from one thousand nine percent renewable sources. Is it a possible yes or not oh no. Is it possible for a tropical country that had the highest rate of deforestation in the world in twenty years news to revert that process. Is it possible yes or no is it possible to achieve growth ended the economic wellbeing at the same time as we invest in nature yes or no today what. I want to tell you categorically. Gorki is that the answer is yes. Yes we can do it. Yes it is possible because Costa Rica as a middle income. Come country has been able to do this. There is no excuse for countries with more resources and possibilities to do the same Carlos over although cassava president of Costa Rica getting down to the Science Prime Minister of Iceland up next Iceland's electricity and heating now comes one hundred percent from renewable. Was this hard work. Yes did it cost of course arse but clean energy transformation was perhaps our best investments in terms of both the economy and the quality of life and I am convinced at the investment we are making now in implementing an energy shift in our transport system is going to be vital to fight the climate crisis but also going to be we are very good investment for our society and our economy in Iceland we have lost ninety five percent of our loans since settlements and health of the fragile child canucks soil and we are now reversing this our island is getting greener this year the government launched new projects to heal the land and soak up carbon from the from spirit at the same time using innovation to pump carbon dioxide underground transforming carbon dioxide into solid minerals in Bass soft rock speaking for small islands often bearing the brunt of climate change Barbados Prime Minister Mia a more motley. The science is clear and the the evidence is even clearer that the lives of our people have been lost and properties abandoned and these tell the story far better than any speech. We can make this great hall the basis. The Alliance of Small Island states needs to keep temperatures this increases in this global community to less than one point five to stay alive. not this rave but to stay alive. We have as well to look at how best we can blend public resources and to that extent our country has introduced not true disaster clauses in bonds as have other countries in the region bobby therefore recognizes the urgency of Austin and insurance colloquium for interested leaders at the national and state levels of independent nations and dependent territories to to confront what we believe will be a growing crisis with respect to the affordability of insurance in our countries similarly believe Mr Secretary General that the real solution is for us to keep asking people to make commitments commitments that are small in the hope that we reach there but the global community must accept that it is within our power to halt and reverse exclaiming change. It's the world can make it possible to have driverless cars then we surely can find it possible to be able to saying that technology to halt and reverse this climate crisis secretary general. Antonio Guiterrez reaffirmed that though time is running out we can still take steps to improving the health of the planet time is running out but it's not two lights the calls of wisely villages business this and specially young people what taking to the streets to demand that we change our relationship with nature now that lace up our running shoes and weaned the climate race the you've just heard innovators heads of state and international organizations presenting solid solutions to this pressing issue of our time at the UN's climate action summit here in New York. We'll have more coverage for you this week as high level meetings continued to get underway during this busy time headquarters follow along at UN News Dot Org for the latest and be sure to check out our new uncomplicated podcast on soundcloud aimed demystifying what goes on here at the United Nations. This has been a special edition of our flagship podcast the Liz on. I'm Natalie Hutchison. Thanks for listening.
"cassava" Discussed on Smash Boom Best
"Wilhelm christina lopez and laura indeed. We want to give special. Thanks to justin coup austin cross taylor kaufman. Josh holt lindsay davis chip walton melanie tracy mumford eric langham takas then brandin santos chrissy peas and john miller joy. Is there anyone you wanna think today. I really want to thank my mom <hes> for you know bringing me into the world uh-huh making all that rice and showing me the way of the cassava leaves and like pulled out the big guns bringing your mom in oh yeah she'll be in mexico uh-huh and what about you meghan anyone wanna think today i would like to thank my husband who with his undying muddled race has galvanized me for noodles forever and how about you christian. Do you have any special shoutouts today. Dry family for are you in here in harvard is excellent and before we go. Let's call up zeke. He's the listener who suggested the fire versus ice debate. I think the ice would win because i sent its multi ormuz water which can extinguish fire excellent point seek the listeners. Do you have an idea for an epic showdown head to smash boom dot org and tell us all about it. That's it for this episode of smash boom best. We'll be back soon with another debate battle. Talk how it's been rice us all about it. That's it for this episode of smash boom best. We'll be back soon with another debate battle. Talk how it's been rice it <music> and who was that did that.
"cassava" Discussed on KIIS 102.7
"Music now on number one hit music station. One eighteen point seven kiss FM. Two thousand eleven and the fact that the rumor is for the next hour that he's going back to his makes me. Harry happy here. He is with cassava Steen. It's lost in the fire. Let's go. Ninety minutes of nonstop kiss music continues out. Is LA's number.
"cassava" Discussed on KIIS 102.7
"New music. A number one hit music station seven. I'm literally gonna start singing a song at the top of my lungs because it's so good. What ups the weekend? It's new music from Gesellschaft Stein in the weekend. It's called lost in the fire on kiss. Music from cassava Stein in the weekend. It's called lost in the fire. It's one or two point seven kids. Number one, hit music station, Saturday night, whatever it is. I know you're getting into something, right? Give me some food. That's like. Pop. Have no.
Trading Plastics Now
"Twenty sixteen China imported nearly half the world's plastic waste, but a twenty seventeen the Chinese government said it would no longer allow imports of foreign plastics for years. China had taken on more than its share of the burden to manage the world's waste, primarily sent from the US Britain, Germany, and Japan where all that plastic. Wind is difficult to determine Troy data doesn't trace the journey of ways from country to country. Some of it ends up in landfills and oceans China's reports say the plastic surplus grows annually now since the nineteen ninety s when single use plastics e ways plastics began to flood the market. The town of Guangzhou in China has been overrun by the world's e-waste behind the heavy duty plastics of most e-waste are many toxic chemicals. Like those used to make computer monitors these chemicals have leached into groundwater in Guangzhou. And researchers find that eighty percent of. Guava children now live with excess levels of lead in their blood China Mel restricts imports to better protect its environment and people's health the recycling effort as moved to other South Asian countries, like Indonesia, Malaysia where overflow remains an issue, but Indonesia is experimenting with solutions to reduce plastic marine debris by seventy percent by twenty twenty-five their turn it into asphalt and incentivizing companies that use bio-degradable packaging made with seaweed cassava and tapioca mostly plastic recycling isn't always profitable. But exporting ways means we lose sight of where it goes. And whom it may harm using and choosing biodegradable packaging can help make recycling lucrative because biodegradable scrap doesn't lose value like loads of undesirable, plastics. This moment of science comes from Indiana University. I'm Yale Cassandra, Don, Don glass.
"cassava" Discussed on Giant Bombcast
"Bob coleco was doing the like pulling the stories together for the show, but rich was hosting it and keeping it moving. And you know, like rich also kind of had some broadcast style chops to him, of course. And you know, he was. He was really the perfect host for that incarnation of us podcasting because he did he did keep it on track. When rich laughs. It was. It's it really sucked. When when rich left it didn't like they're, you know, he, he had to move he. He had had to move back to Boston family reasons and all this other good good stuff. But it was definitely this feeling of just like we try to keep rich on for something and then it didn't happen. And I remember going to the guy who was my boss at the time, and this was after Greg cassava had taken off for a and I'm going to him and saying, hey, you know, we're like it might not seem like it now, but time is gonna come here were really going to regret letting rich Gallup walk out the door. And he just kind of, I don't know. I don't think he knew how to take that and. And that was rich was which was out. And so I started hosting the show around that time, but I, I don't know. I never especially wanted to host the podcast. It was a little bit easier to react to the host. Than it was to drive the conversation and. Be a part of the conversation. So. I did that for as long as it made sense. And then the same guy told, hey, you are undervaluing rich Gallup. Kicked me out of games. Showed me to HR who you know they went through whatever they, you know, whatever trumped up carpets they had made up to not make it seem like wrongful termination. And you know, then I was out and and to me this stuff that I missed it was it was the podcast. It was doing that podcast. It was because it was fun. It was. It was free form enough to where you know you're just you're kind of just reacting stuff. You're in the moment. You're just kind of making it happen. And to me, that was the most fun part about the podcast and doing anything live like like on the spot and stuff like that. So. Some months later when when we were working with digital Commons, the company that would become whiskey media. It. It was easy to sit there with Ryan and say, hey, here's the here. The two things about working at gamespot that weren't a fucking grind that we we didn't. We hadn't really started to actively dislike, and it was a podcast and you know that idea that kind of free for me live type stuff. You know the the tech to to go live on the internet was not what it is today. So you know that took some time. They're still video. I think it's on our twitch channel. There's an old video of me like pointing a webcam or I don't even know what it is phone. Probably not a phone, pointing something at a TV on the day that GTE four came out. But anyway, I don't know. We podcast because we had to like I felt like I felt like a real need to do it. So even before we had a name for the website, even before we had a name for a podcast. And all that sort of stuff. We started a podcast almost just to keep busy in a way because things were just slowly coming together. And I want to say that. We were, we were getting paid. I wanna say we were technically employee's at that point, but we may have actually started that podcast before we really kind of become. Part of the crew part of the comic vine slash. I guess there's no slash. It was comic vine and they were building political base Buca the car site, the car site, then. And so we started recording..
Oracle earnings show another cloud miss, stock falls
"Checked him with a few analysts, get their hot take on or. Results. Let me bring those to you. Joe fish bind over BT. I g telling me overall revenue cloud revenue and cash flow were slightly below expectations. Another quarter that shows their inability to appropriately guide the street and execute need to wait for the call for guidance, but stock reaction at aftermarket shows very low confidence. Even though the shares are very cheap relative to the rest of the market also checked in with Steve Koenig over Wedbush. Here's what he had to tell me on a constant currency basis. Oracle can argue that it met expectations, but this market has no patience for any MRs from tech companies, no matter how minor or how explainable the miss add to this. The setup for oracle shares is challenging because the stock has climbed from forty three posts that week q. four to over forty nine at the close today. And finally, Pat Pat wall ravens at j. saying, one interesting metric is at the platform, an infrastructure business, which is basically database accelerated from negative three percent to two percent on a constant currency basis. Meanwhile, the applications accelerated from. Mm four percent to seven percent on the call or cassava cats giving guidance here, Scott total revenue. She says, going from zero to two percent non gap EPS. She's calling for between seventy seven and seventy nine cents. That was a bit conservative relative to expectation, Scott. All right,
"cassava" Discussed on Programming Throwdown
"Sometimes it's hard to work remote, but are there any positions or good fit? Depend more on the company, culture, co workers, cassava is sure the answer is it depends. All right. Done. Yeah, I don't know. I've never actually. Have you ever. I mean, we've never worked remote, but have you ever done? Let's say a remote project. Know everyone else's somewhere else. So for the most part, I haven't. And I think this largely depends on where you work in the company. So we both work in California in the bay area, so near sort of San Francisco, and it's not super popular here. It's beginning to get more notice. But in actuality, some places are kind of moving against it and trying to bring more people into less locations, forget sort of even like work from home or or work remote. I support roles. I see a lot of people covering different time zones and a lot of sense to me. But in other roles, I don't see it and there are a lot of problems with it. I would love to see it work well, but I've never seen something where in the kind of work I do, which is highly collaborative sort of a lot of speculative work a lot of day to day change. It's not so much like here we have a product and we're just trying to sort of burn down bugs that have been filed against a product. Remote work is kind of hard to do, but I guess in that way, I could see that some work would be more well-suited to it. Right? Yeah. I know somebody who was he. They were doing a startup and each person who was basically in a different part of the of the globe and. Ended up actually working out pretty well because the startup was very focused. So basically they were trying to do speech to text. And so what they do is they would do pitch. So all of them would have to fly to this customer pitch them on their product. If the customer bought it, the customer would give them just a ton of voice recordings. Then they would pay contractors to manually transcribed them and then they would write computer programs to try to match that. And so there is a person in North Carolina who is doing, you know, just trying to get the audiences right? And he had sort of ground truth of what the right utterances were. So just you is just getting the accuracy, higher and higher, but there's really there wasn't a lot of collaboration. I mean, if one part of the system got much better or changed, I guess they'd have to tell everyone downstream, but in the grand scheme of things, it's not. It's very low. On the scale of collaboration. And that's to work pretty well for everybody. But yeah, I think what Patrick was saying you most jobs aren't like that like in most jobs to collaborate. And so being remote is pretty difficult. But that being said, I people talk about it more now than they used to. And I think there's increasing desire for people to begin to have that as an option. But also like just being brutally honest, some people do better remote work than other people like it's a, it's a different skill being able to sit. I guess it depends on what you mean by remote. It's like work from your house by yourself. Some people are very well suited to that. Others are not very well suited to that. They get distracted. They don't work as hard, and it just depends. It's a person by person thing, and then your company's reception to it is different, but I'm also attended to work at pretty large companies, and I find that being in the office, having FaceTime with the bosses like meeting people that kind of stuff. Helps me do well in my career more than straight up. Just like being an amazing programmer is also important to do, but you know, having that FaceTime and having people know who you are in keeping communications open, you know, making sure I understand what's needed, and then doing those things that are needed is important. I feel for me, some of that would have been lost if I had not been in the central office where most of those people were. Yep, Yep, totally makes sense. I agree a hundred percent if you can avoid remote work. I mean, not not if you can avoid it, but like definitely take into consideration fact that the FaceTime is really, really, really important..
Review: 'The Spy Who Dumped Me'
"Hasn't he thinks a also does ticker, right? Yeah, he has a wonderful, wonderful. Originally Gilbert, Godfrey was supposed to. Busy being. I found it very moving, and surprisingly touching said in the back row weeping for my lost childhood, bring all the things that are no longer available to me, I think is a great family flick. So that's good. I saw the Middleburg film festival had a screening of puzzles. Stowing Kelly MacDonald, right? Yes. And she arrived in town and first of all, I would like to say she's very open about this. She's forty two years old and she looks like she's twenty five, and that's why she is a movie star because I won't tell you how old I am, but I look about thirty years older than that. And it's a nice little. Movie of a of a downtrodden housewife who finds her Mojo doing jigsaw puzzles that she finds a partner and, and you know, it's, it's not exciting. It's not. It's not loud or anything, but it's a nice. It's a, it's a nice coming of age film and don't just Google jigsaw accidentally. Cassava, Papa torture porn totally different than what you. Yes, she is a lovely actress in. We're talking about this the other day. I think it was off Mike, but just some of the things that she's been. She was first in Trainspotting as a child. Essentially, he was the baby on the ceiling. Boardwalk empire. She was in no country for old men. And that's to me because I know she Scottish and beautiful doing the boardwalk empire thing was very hard because she was Irish desires, but the southern Tekere western Texas accent. She had. She might as well been born in Odessa. Here's your own lady bird. How do they do? I don't know. So I'm a big fan and it's it's a lovely movie, and I saw the spy who dumped me the other night because somebody needed to go to that. Kunas and Kate McKinnon, and it's not very good would expect. And Kate McKinnon is squandering her talent. And so I am worried about she is Uber, talented, death, but even I think we all agree and you should never judge a movie on the trailer, and then we saw the trailer. It was like, oh, no, really? And so that you're telling me that my fears are confirmed. They play it like a Saturday Night Live sketch except it's two hours law to our. I wrote this down. It's one hundred sixteen minutes when she's Larry on SNL. I wonder why. I mean, what is it that you Ghostbusters. Needs to develop her own material or work with people who know her to develop stuff for her. That really doesn't have to just take any script. Melissa McCarthy will write her own. Sometimes it's hit or miss, but sometimes hilarious. Even Melissa McCarthy, I was thinking Melissa McCarthy because she needs a new breakout something to get her to the next. She's doing the same thing over and over. Again. It seems to me and Mila Kunis was hilarious. And Ted ten thought was Jerry, so they both can do it, but not this time not time. So here's a reminder and Hornets when she's in town reviews at Washington Post dot com. And I'm arch.
"cassava" Discussed on KQED Radio
"You're listening to all things considered from npr news remember acid rain in the nineteen seventies and eighties scientists found that rain one hundred times more acidic than normal was harming the mountain force of new england the pollution was linked to fossil fuel plants in the midwest now a new study shows red spruce trees are recovering after decades of damage from the new england news collaborative john dillon has this report on a steep slope in the green mountain of her mont forest researcher alexander cassava does it kind of medical exam on red spruce tree cassava everyone calls her allie uses a long drill like instrument to extract a narrow slice of tree all the way into the core that's sounded makes friction with pushing through because basically cutting wood as it goes through moment of truth this sample backs up with kosiba and her colleagues observed in a recent study of red spruce in five northeastern states after decades of decline the trees are healthy again that looks like the recent growth is quite large and if you go back a decade they start getting a lot smaller and even another decade they're they're really tiny indeed three decades ago the news was much more grim millions of trees like this one were dying their needles read in their growth stunted the reason was acid rain it's caused when pollutants released by fossil fuel plants down wind of new england chemically combined with precipitation and leach calcium out of the soil the calcium depletion.
"cassava" Discussed on KIIS 102.7
"I'm ginger chan you on air with ryan seacrest i want to 27 cassava were your way in for the first quarter no tricia porter of british puerto brit calls back thirty minutes right now call back in thirty minutes to get into the for forty for a shot to win a 2019 infiniti q egg fifty you plenty of next week meet angela at uc sb originally from englewood huge phantom alumina i got a surprise for next kiss fm both both keep millions on this i thought this the moon volume thunder than vinyl siding burma comment on that end the birds is decent at the elbow and dealings as netanyahu magazine named anthony hill feelings now now the mouth development babies polygon grave the panel belmont live those who spoke x his birth these are these routes had you'll be enough no of suits lenovo liam neeson in an ezln and combating hopes injury stay in thumb i am the take the bag down there well done and of them can china these it is good eu these do make camps and not be of a man is yeah berbizier theses no them the.
"cassava" Discussed on KIIS 102.7
"That cafe book but on you're ginger in los chan angeles on air with and ryan new seacrest york own achievements that on cassava you i okay love many that on is the streets neither office do we garrison stepping inform i'm glad garrison you're smelling vinegar air but from i in here at about the new or york parker studio gregorio offered jerian forty but paragraph tani always earned a team during will give player carte because beat you marty dragan welcome every morning to the there when were i wake inferior up from arthur what into is that wearing apple johnson cider jericho art in cabin arc that wrong signals for come on out i'm bureaucrat i building can see for many you on i can a smell you urinary i can grind hear regret you but on what handsome did you l u give tubs them can we get screens that smell i can see them on the computer greely actually am right now rods comment facetime on amendment foia outfield his aright igor act style show is speaking of facetime run as never egg good time hasn't i for always me be small you to get the right angle style with that you too hard on yourself i honestly meanwhile elmi don't gone of look terrible arnold and facetime usual numbness chad sows momis one of on your die they made that dino gotta die you are with came back and that goes on his recipes moscow gaza ebro as mouse he has made a lot of goma's saw the forum's nays friday name anemic shot in a car it was legendary nor tv i know in around on us donen said look don't give a damn good job iranian louisiana john again sudan on when the i did not see in leonardo luggage on obama as on it man man in a run of little above impoving mieno futures i go rockstar runas magazine i always mom you go style meanwhile me gone of arnold new showa amnon shahak zayat's momis monologue on your naming then tangled ton abbas a hails he'll superstars fillon like pop star gaining bad jumping in the pool in nagpur antonio brown data fan of bed linen on a treason nash grinned and now no ma zhu daylight servers why you've got a to a car garage.
"cassava" Discussed on KIIS 102.7
"Plus seven extra fifty percent any way you want to pay with coupon 'skandia pennies worth jc penney i'm ginger chan you're on air with ryan seacrest salinity when something cassava it's going to be a gorgeous weekend temps in the midseventies along the coast very good beach day a mid eighty's downtown and low '90s inland you're in riverside right now at sixty four in hollywood i guess with abc's set me rolled your shot at more free money a turn i saw here's the youngest graduate of cal states la clause 2017 eat them at the start when he was eleven years old these with us next at kiss oh we dogs we turn her her burn the new swallowed overuse shoulder for a minute storm kozo move forward you coors sure uh i mean for us it already do you engage you do citing an ounce but we oh god jeez with so i grew curve say kids good the lowkey the looked shown woman altogether i do no june let us every day you get you so.