19 Burst results for "CYP"
"cyp" Discussed on Effectively Wild: A FanGraphs Baseball Podcast
"So Jacob, a teed him up last time when we had Richard hershberger on. There's been a changing of the guard a passing of the baton here and Jacob is taking us through the first half or so of the 20th century, at least after Richard took us through the last half of the 19th century. So Jacob, as I mentioned, is sabers director of editorial content and he's also the chair of the black Sox scandal research committee. He is an expert on the black Sox. So when we get to the 1919 period, you will have plenty to choose from for past blast, but today we are talking about 1902 because this is episode 1902 and Jacob says the relevant newspaper quote is not very long or detailed, but it's the only contemporary mention of this really cool moment that's never happened before or since. So 1902, he says is the first and only MLB matchup of two deaf players. So on May 16th, 1902, a historic meeting took place at Cincinnati's brand new ballpark called palace of the fans. Two deaf players appeared in the same game for the first and so far the only time in major league history. In the bottom of the first inning, red center Fielder William hoy led off against Luther Taylor of the New York Giants as the Cincinnati inquired reported when hoy stepped up to the plate, he paused for a minute and used sign language to mark the occasion. This is the quote hoy signaled I'm glad to see you to his brother mute the newspaper says and then soaked a leadoff single to center. Hoy was almost 40 years old and in the final season of a decorated 14 year career, he went two for four and scored a run, but Taylor and the Giants won the game 5 to three. Hoi and Taylor were friends off the field and would remain so for the rest of their lives. Cool. They were part of a small baseball fraternity of deaf players in that less sensitive era nearly all of them were saddled with the unfortunate nickname of dummy. Because of their disability. Yeah. Baseball reference has since changed the display name for hoy. I believe I recall reading that he you just that nickname himself that he did not seem to object to it or at least he went along with it, but who knows. Certainly sounds derogatory to modern years. You will usually no longer see his name displayed that way. Yeah. Jacob continues after winning more than a hundred games for the Giants, Luther Taylor went on to teach and coach at schools for the deaf in Kansas and Illinois. One of his students, dick seip, made it to the big leagues with the reds in 1945, cyp was the only fully deaf player in the major leagues for 80 years until Curtis pride joined the Montreal Expos in 1993. Well, all right then. Good pass blessed. Yeah, good past bless. All right, thank you, Jacob. All right, that will do it for today. Thanks as always for listening. By the way, we talked about my trout streak of 6 consecutive games with a home run. Well, he made it 7 on Monday. He's now one short of the record set by Ken griffey junior, 8 games in a row. Just battling for second place in the AL home run race. Really
"cyp" Discussed on Bloomberg Radio New York
"Implosion of their once high flying crypto hedge fund. They're saying their crypto speculation unleashed cascading market margin calls on loans that never should have been made. Sushi and Kyle Davies built three AC into a crypto trading giant before its collapse bankrupted creditors and exacerbated a sell off. You can read all about it at Bloomberg dot com right now it's one of the most read stories on the terminal. Meantime, South Korean prosecutors raid the home of terraform labs go founder Daniel shin, their deepening a probe into allegations of illegal activity behind the collapsed, stablecoin Terra USD. And that's your Bloomberg crypto update, live in New York, I'm renita young Bloomberg radio, Karen. All right, we need to thank you. That's a Bloomberg business flesh. Your quote in Dogecoin? Renee? It's a part of our CYP function on the terminal. It is. It's gone from 57 cents to cut them some slack. The real trend starts at 34 cents. And we're enjoying it this morning at 7 cents. 7. I mean, I guess that's a deal. Karen, if Karen quotes it, it's a thing Tom. If Karen reneta quotes doge. Yeah, keep carrying out of this. It's part of our index. The doge is part of our index. Well, okay, to be sure, I'm not sure if it's part of the Bloomberg crypto index, specifically, but it's definitely on the CRP function. Boom. Really? Yeah. Check it out. I learn every day. It's just amazing. Yeah. Well, you know. I'm waiting on buying the doge you're talking this time, et cetera. Two sensors. Check your Twitter. I think thank you, Renee. Thank you. After thoughts at home taking notes, we got to go long. Doge. Speaking of doge, let's look at another Dow equivalent. Joins us now with Bloomberg intelligence. Man, deep, I don't want to talk Elon. I must out. I want to go to next week. What's the mystery for you next week in big tech earnings? I mean, alphabet and meta, right? So we heard how bad SnapChat was last night. And I think look, overall, spending environment has really taken a big downturn. I think part of that was related to the tougher comps. These companies had getting into the quarter. But also inflation is playing a big role here. And I think inflation, if you go back in time, historically hasn't been good for ad spending, because companies have to pay higher costs. So they back on advertising. That's the one thing that's easy to pull back on. And so that's what you're seeing overall. And it will be interesting to see how badly it affects neta and alphabet. Mandeep, I mean, over the last 20 years, what the wind at the sale behind the facebooks the googles, even the snaps and the twitters and the Pinterest of the world has been this secular shift of advertising towards digital advertising away from some of the more traditional analog advertising such as newspapers and TV and radio and so on. Is there any reason to think that that's slowing that margin share shift or is this again more of a cyclical recession driven pullback in ad spend? Look, I think the trend is still there because digital advertising is more measurable. The problem is Apple has changed the rules. So the measurement techniques that these companies had developed, now have to be redone. Add optimization at a targeting has to be redone because Apple has made all those privacy changes. And so over time, these companies will do much better, but for now, brand advertising is holding up much better and that's why you see the ad agencies actually doing on a relative basis, they are growing low single digits, which is much better. Are we going to what I see on YouTube now, Paul helped me here. The average Ed is 5 seconds long, like one Mississippi two, Mississippi. Is that where we're going, man deep is where 15 seconds is going to be a long, long, long ad. Yeah, well, I think the trend is towards short form videos and then within short form videos they're going to embed those 5 seconds as the problem is they can target those ads for you, Tom, because of the privacy changes. So they are not getting the signals to show you the right kind of ad that you would want to say. Mandy, it's probably no surprise to you, but Tom keen is a big TikTok user here. Talk to us about TikTok as an advertising platform and how advertisers think about that and how that might be a competitor to the facebooks and the googles and youtubes of the world. Oh, absolutely. I think part of those are tied to how well TikTok has done. And I think they are clearly taking share here both in terms of time spent on the platform, as well as the advertising dollars. The one caveat I have about TikTok is around brand safety. There are certain large advertisers that are very focused on brand safety. And they may think, okay, not everything that is on TikTok is closure for them to show their ad mix. To the video that is going on take that. Continue, Mandy. I'm sorry. No, and I'm saying like that's where if they have to get the large advertisers on the platform, they really have to work on the brand safety aspect. I'm combining this morning's younger people than me, zeitgeist. I'm looking at TikTok in a white claw TikTok video. And she is frothing her white claw. Yeah. That's a talk about that. We brought it all together there with white claw on TikTok. Do you see white claw on the beaches of Jersey? All over the place. And it's mostly with the young ladies. The young ladies. And that's the thing. Mandy, are you all heard seltzer? Yeah, well, I guess I do a lot of things that I don't want TikTok to talk about, you know, in my social media feed. So yeah. Well, thank you for the brief. I'm sure we'll catch up next week with Facebook and what's the other company? I don't know, Google and maybe. So what is it like Mandy can only cover companies that change their name? Exactly. Discovery primary next week. Exactly. Exactly right. All right, man deep seeing that. That was all things tech for Bloomberg intelligence we appreciate. Data check SPX up a single point here on a Friday Dow up one 41. The vix is a big story this week, 22.84 also German yields plunge this morning on difficult economic data, stay with us. This is Bloomberg.
"cyp" Discussed on Ben Greenfield Fitness
"So we have basically all of these components working together. You've got the cinnamon, which is going to inhibit the CYP enzymes and thus allow for anything that is placed on the body topically or consumed along with the cinnamon to kind of like stay in the bloodstream or have heightened activity for a longer period of time. And I know that that some of the cytochrome inhibitors and cinnamon I think there's one called beta carotene that makes your cell receptors more sensitive to say like the THC in cannabis. You'll even find that in some topical muscle creams and things like that is they'll put components in there that have that beta crawling in it for that reason. I think murr has some of that as well. And then you've got, of course, the cinnamon is dilating the skin capillaries and I think it's also got some other things in that mix that would have some apparently like LSD like psychedelic properties like the safrole and the Australia and the LMS and things like that that you mentioned. Yeah, so the beta Caroline it works on the CB two receptor. And the CB two receptor is really complex because THC pushes it in one direction and CBD pushes it in the other direction. Yeah. So it gets really, really complex there. But then the CYP two D 6, which is the which is the enzyme which is inhibited by cassia. That one is activated more by cannabis, right? So these things get really really complicated. So basically it becomes more efficient under the influence of cannabis and something which I find absolutely fascinating in this is that when you look at which one is the song of Solomon, I'm going to read it to you, actually, no, sorry. Yeah, it's proverbs. This line from no, sorry. You know, strong assignment. That plants are an Orchard of pomegranates with pleasant fruits. And then it gives a list of. Plants which are psychoactive. Campfire with spic and art, pick an art and saffron cane, which is cannibalism. Cinnamon, with all trees of frankincense merr and a dog would with all the chief spices. Now, everything I've just listed there with the exception of campfire, which is we know as henna, has you can go into journals of pharmacology psychopharmacology. And you can find the effects that they have on the gaba system and the effects that they have on the opioid system, et cetera, et cetera. And then you've got thy plant to an Orchard of pomegranate. So it's got, you know, it brings in the pomegranate. So I looked into the pomegranates as well. Pomegranates are fascinating for one thing they are super food and but pomegranates all have effects on these enzymes. And that one I just mentioned before, which was CYP two D 6. The gene which produces that enzyme gets switched off if you eat enough pomegranate. So basically, if you eat enough pomegranates, you will have less of this CYP two D 6 in your system, which means that you'll have if you take cannabis it won't have so much CYP two D 6 to increase the effectivity of. So you have another level, I think there's just a hint of this because it doesn't say that they get a whole load of pomegranates, but it does say in this particularly fascinating Orchard of plants, there's an Orchard of pomegranate, so there's loads and loads pomegranates, and then there's all these all these other things. Yeah, yeah, well, it's similar to like grapefruit, you know, pomegranate is a cytochrome enzyme inhibitor. That's why I got to be careful with grapefruit consumption along with different pharmaceuticals or other compounds because it can markedly increase the absorption of that or kind of amp up the effect or cause it to be it can cause it to be like spiked in the bloodstream more quickly or at least more bioavailable in greater amounts. And I think pomegranate is very similar to grapefruit in that respect. There's a lot of modern day supplement manufacturers and chemical at home psychonaut tinkerers who will mix grapefruit in with different compounds for that kind of like that amplifying effect that grapefruit has. And pomegranate may possibly be doing something similar, right? Well, yeah, there's a really interesting other line on pomegranate, which is in the myth of persimmon Persephone and Demeter, which is the myth of going into the underworld, the character who ends up getting taken into the underworld, she gets told she eats 6 pips of a pomegranate. And because of that, she has to stay in the underworld for 6 months of the year, which is why we have winter. That's the story of a winter. It's a super interesting thing because it doesn't say that the pomegranate took her into the underworld, but it does say that pond McGregor kept her hair and kept her there longer, which is exactly what you'd expect from if we're talking about something which switches off the gene, which makes a cytochrome enzyme, which increases the length that a psychoactive compound has an action. Interesting. Okay, so we've got all of this stuff being basically burnt in what would be the equivalent of like a hot box as you alluded to like the inner super duper closed off almost like the inside of the holy of holies was designed in this very, very precise manner that you described to basically keep all these chemicals kind of concentrated in a container for this incense to the extent to where and correct me if I'm wrong but didn't the high priest who would enter into that chamber after being anointed and then begin to begin to burn some of the compounds we'll talk about here in a second. Didn't they have.
"cyp" Discussed on Heartland Newsfeed Radio Network
"Jacobs from colorado comes in and wants to compete with them and so they just made a twenty dollars a twenty year contract. He'll that gives them carte blanche access to so much for the call tonight. Rats feed Certainly sounds pleasant but the call sounded fantastic. You wanna sounded good kois via the cyp line. That's f. t. l. dot on dot info. You'd like to do that. Thanks for keeping us in the loop about what's actually happening in happening and reno. I would not have guessed it. Six zero three two eight three six six zero. It's free talk. Live when a lunar observatory detects a radio broadcast originating from proxima centauri the nations of earth discovered. Their first contact with an alien race may also be their last with approximately facing extinction level. Disaster earth must choose between sending a ship on a multi year journey or allowing nature to take its course saving proxima a hard science fiction thriller by travis s taylor and less johnson.
"cyp" Discussed on Code Story
"Our he said of building costing that can icon for any type of website at cyp ecommerce step side that can also made The integrative it's cd-roms and let's bet stacey and integration into the product. Nope we we so. It's better just to keep simple. But that can be really fast and optimized so into it also commission and yet i would say that Also have cast murphy nick helpless. Look because we my temple of ideas with really constantly vomits them. How did you go about obtaining that customer feedback or validating new idea or figuring out what the market was asking for. How did you go about that process. I ate voss say just envied version of a customer feedback. Who she be. Just did some chad where customers can could provide some questions support. It's more it was more about support and then reviews k. But really important part of feedback. His first you can talk to you shoot. Cook gossamer so we started to talk to customers directly by calling them resume have long conversation and also ask a question about a questions not only about all pro but the bow. Then how do they work. If that spent agency how do they create feb sites was their processes challenges. They had so it was the real most meaningful customer feedback and the second thing is that we really focused on data now. We are really data driven company with data team global date. There's more data. Dan became percents. And it's beautiful. When you wanna analyze everything the way your customers attracted product so this took things help us now to focus on the things that really matter. Well it's to team. So how did you go about building your team. And what did you look for in those people to indicate. Okay there the winning horses to join you. Thanks to the previous experience. We had some court teeth that Mostly engines saw an are bet. Melissa leak caused there were really great. People and i'll say they great team peak these people who can do their job better than their managers are dan. The company founders. close manure. You grow you need to delegate to them and it's good that you have such a team that candle. I'll artists nice in that aspect so rather hands. We beauts not only engineering. It was our strength engineering team but we expanded more into other aspects link. Martine customer support and l- of stuff. So when i prioritize this stuff gets it's not only about peeling technology and writing code refers. Prioritized i mean we co-founders and We try to try to find who can't be the best people do community. Who can join the team although we didn't have much experience with these ferrets. So it's kind of risky think that you would hire team that you are not expect off but i would say we succeeded in that. This episode is sponsored by image. If you're ready to add photo or video editing to your application immensely is a crepe places start. Image provides a software development kit. That handles all the technology for adding photo and video editing. Right inside your application there. Sdk's are fully customizable and can match your apps look and feel and support all major platforms. Let users share beautiful photos or videos. Create imagery for marketing campaigns. Bill photo books were even automate design with templates. Their video and photo editor 's decay is used by shop fi who sweet shutter fly and hundreds of other companies helping them. Ships offer faster immensely software development. Kit is the fastest way to add photo or video functionality to any application visit i n g dot l. y. slash coat story today to try the web demo- that's img dot l. y. slash coats. Story this episode is sponsored by radical. Are you interested in joining a team that encourages intellectual curiosity problem solving and openness. Not only that but one that provides the support and mentor. Ship needed to succeed. Learn and grow meet double the team at radical has built a world-class platform for modern bill payments payouts and invoicing radical helps companies speed up their business payments using a secure invoice and bill payment system. And not just for accounting groups. The company is solving problems for the cfo. Controller the accountant and the developer. Radical is engineering lead and fully remote. They're looking for the best engineers and operators to join their team and drive forward their mission of removing the burden of business payments to apply today go to radical dot com slash about and click view. Open roles that's our. Ou t. a. b. l..
"cyp" Discussed on The Meb Faber Show
"Very clean clear investing policy to make sure that there's no adverse selection every farm. Go through the same diligence underwriting process select. Everyone gets the first pick. I often you guys kick out the farms during due diligence in what are the main reasons is evaluation referred to water earlier. Is it something else. Depends how we define your diligence because the way it works is that it was sort of due-diligence Every step of the funnel by if we were to define it as due-diligence signing the escrow in putting in the deposit than not that often actually quite better we did have a demon q. One where already during the escrow. We found that the was until liking was too risky so we walked away but most of the times especially because of the tech that we use on farm satellite imaging experienced with developing regions when we do underwriting one time. Let's if what district we know. That was good. It's not that often. There will actually or kuwait but it can happen. Most definitely will happen again and again. Because that's what you diligence is for starting. Thank you just cannot analyze enescu once it's up and operating what you guys sees. The main risks longtime listeners have heard me moan about one time we were doing a wheat harvest in our combine caught on fire and earn down the entire crop thankfully. We have insurance so two part question. What are some of the risks that you guys have to deal with wanted. Operating and to these have traditional insurance covers operational risks. Yeah definitely me around us for the main risks. Wondrous happens before you buy the farm which is just making sure you're by the right price so you have to look at third annual so for us. Great validation has been loans 'cause a lot of the farm steak on debt to improve the returns. So i'll find cyp appraised at or above the press Bank said yes but had direct price. So that's a great.
"cyp" Discussed on Sips, Suds, & Smokes
"Each day <Speech_Male> at cyp sud smoke <Speech_Male> and our facebook <Speech_Male> page is always buzzing <Speech_Male> with watson news <Speech_Male> can also enter <Speech_Male> interact with the other <Speech_Male> fans on that <Speech_Male> social media platform. <Speech_Male> You can also check <Speech_Male> us out on instagram <Speech_Male> at successes <Speech_Male> smokes or at made <Speech_Male> man. Bob <Speech_Male> do us a favor and <Speech_Male> take the time to write this <Speech_Male> episode. If you're listening <Speech_Male> to big help to us and we <Speech_Music_Male> get your feedback <Speech_Male> as well <Speech_Male> want to thank our co <Speech_Male> host for <SpeakerChange> joining us <Speech_Male> today. Thank you brent <Speech_Music_Male> you. <Speech_Music_Male> <Speech_Music_Male> While i'm burned <Speech_Male> drinker the cisco <Speech_Male> a show like this <Speech_Music_Male> just goes to show <Speech_Music_Male> that not <SpeakerChange> all scotches <Speech_Music_Male> bad <Speech_Music_Male> in or can't be <Speech_Music_Male> good. <Speech_Music_Male> <Speech_Music_Male> <Speech_Music_Male> <Speech_Music_Male> Okay <Speech_Male> thank you. <Speech_Male> <Speech_Male> Thank you bob. I'm <Speech_Male> speechless after <Speech_Male> that last comment. <Speech_Music_Male> Aren't <SpeakerChange> we all <Speech_Music_Male> thank <Speech_Music_Male> you. Chester <Speech_Music_Male> thank you so <Speech_Music_Male> much. <Speech_Music_Male> <Speech_Male> <SpeakerChange> I swear <Speech_Music_Male> thank you harm. <Speech_Male> Thanks <Speech_Male> bob not all <Speech_Male> scotch is good <Speech_Male> in life <Speech_Music_Male> too short to drink the battles <Speech_Music_Male> <SpeakerChange> <Speech_Music_Male> <Speech_Male> thank <Speech_Male> our co host for joining <Speech_Male> us today and <Speech_Male> this is made <Speech_Male> man bob. Thank you <Speech_Male> for joining us. Remember <Speech_Male> way is too short <Speech_Male> to drink. Bad whiskey <Speech_Male> <Speech_Male> fortunately. <Speech_Male> We didn't have to <Speech_Music_Male> do that today. Oh <Speech_Music_Male> <Speech_Music_Male> well <Speech_Music_Male> maybe. That's smokey <Speech_Music_Male> stuff <Speech_Music_Male> i see <Speech_Male> question at <Speech_Music_Male> <Speech_Music_Male> avila <Speech_Music_Male> wiggle <Speech_Music_Male> villain. <Speech_Music_Male> An <Speech_Music_Male> <Music> <Music> <Music> <Music> <Music> <Music> <Music> <Music> <Music> <Music> <Music> <Speech_Music_Male> this <Speech_Music_Male> <Advertisement> has been a one tan <Speech_Music_Male> <Advertisement> hans production <Speech_Music_Male> <Advertisement> of <Speech_Music_Male> <Advertisement> suds and smokes <Speech_Music_Male> <Advertisement> a program <Speech_Music_Male> <Advertisement> devoted to the appreciation <Speech_Music_Male> <Advertisement> of some <Speech_Music_Male> <Advertisement> of the finer slice <Speech_Music_Male> <Advertisement> of lightening <Speech_Music_Male> from the dude in the <Speech_Music_Male> basement studios. <Speech_Music_Male> You're host the <Speech_Music_Male> good old boys will <Music> see all <Music> next time.
"cyp" Discussed on Real Life Pharmacology - Pharmacology Education for Health Care Professionals
"And i kind of breezed through the earlier sections of a little bit more quickly because drug interactions with fluvoxamine are so critical I've had numerous situations where fluvoxamine mean has caused various toxicities and or issues so Let's think about many of the cyp enzyme. So sip one eighty two Fluvoxamine actually inhibits cyp. One a two So a drug like claws ping definitely a drug that's very sensitive potentially to concentration changes Those concentrations can go up due to Adding fluvoxamine on board The effects of caffeine and other one through cyp one a two. If we inhibit cyp one a two caffeine effects can go up Orlando pain and other antipsychotic affected by cyp one. A two so numerous drug interactions. They're potentially In addition Patients who smoke can actually have lower levels of fluvoxamine member smoking Induces cyp one. A two who've oxygene is partly at least partly broken down by cyp twenty two and so flu vaccine concentrations can go down as patients Or smokers can have lower levels of loxton. If somebody stop smoking those fluvoxamine levels can go up so definitely can be a very complicated Type of situation there Fluvoxamine also inhibits cyp two c nineteen. So if you remember a few drugs here Benetton at least in parts broken down by cyp two c nineteen I have absolutely seen a case of benetton toxicity. Because fluvoxamine was added to a patient's medication regimen Other medications increased concentrations of mapra sol And also potentially Reduced effectiveness of drug light clopidogrel. Remember that one is a pro drug and is impacted by cyp. Two c nineteen activity sip to see nine so Fluvoxamine is technically classified as a weak inhibitor of cyp two c nine and if you remember war friend is broken down significantly by the enzyme To see nine so we can end up with elevations in irr in increased orphaned concentrations. If vaccine is out another enzyme that fluvoxamine impacts is cyp..
"cyp" Discussed on Relacionamento Fora da Caixa
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"cyp" Discussed on The Carlat Psychiatry Podcast
"The human genome was mapped in two thousand and three and with. It came the hope that we could one day taylor. Treatment to a patient's genetic fingerprint. The white was not long. In two thousand and five the first pharmacopoeia. Genetic tests were released for the metabolic enzymes. Cyp two d six and cyp to see one nine. Those tests were approved by the fda but most of the commercial genetic panel said of cropped up since then are not approved and that difference is important to understand when we talk about genetic testing. We often talk in. Black and white terms like is genetic testing useful or not. That's a bit like asking is laboratory testing and psychiatry useful or not clearly. The answer depends on the patient and the test involved so while individual tests like cyp tutti six and to see one nine are fda approved most commercial genetic panels like the ones that draw promotional literature. Your office are not approved and not generally recommended by experts. One of the most prominent of these is gene site which was released in two thousand nine gene site with developed by people from male and then it was commercialized through it. Sure acts and then assure acts was sold to marry a genetic which is a huge corporation. So now it's certainly commercial but it was developed by academic investigators and there's a paradox with genetic testing. Well individual tests might be sound when you pile bunch of those together in a pharmacogenetics panel. Not so much in the carlisle report. We've covered half a dozen studies that tested these genetic panels out in real world populations usually impatience with depression. Who failed to respond to an antidepressant. Now you would think that was an enriched design that if you're going to see a strong signal with pharmacogenetics testing it's in people who didn't respond well to anti-depressants that these tests automatic difference the time and again they full show it. We covered one of those failures. Some in a large trial of the gene sipped test. So what is going on. If some of these individual tests are valid. Why do the genetic panels failed to work well. They don't exactly fail to work. When you stack all those failures up you do see a small signal pointing towards successful outcomes with genetic tests. The meta analyses of pharmacokinetic genetic tests are actually looking pretty favorable recently. Not the ones on the snl lille of the serotonin transporter which have been more or less negative than the ones on the cyp enzymes particularly to six and to nineteen are looking pretty good at at this point and i participated in one of them a few years ago and i was impressed with the care that they took and designing the protocol and i think it was good study this month. We interviewed john. Nuernberger about which of the dozen or so genes in these pharmacogenetics panels are useful and which ones to take with a grain of salt their genes. That would be most important would be cyp to six and to see nineteen little bit. You know. three four sometimes gets thrown in. But mostly you're looking at tuten six and to see nineteen grants the presence and and so when i look at the report. That's what i'm mainly paying attention to. And i'm i'm also paying attention to the broad recommendations of go which medications particularly avoid you take with a grain of salt. But there's you can see where the evidence i'm from and i'm particularly interested in than saying that evidence for two d six to see nineteen dot number recommended. Cyp two d six and to see one nine and those are the same tests that were the first gain fda approval in two thousand and six. Those are the top two an online interview. He delves into other genetic tests that deserve a place at the table but whether the test is useful or not depends a lot on the patient. Here's what datta nuremberger thinks. Genetic testing has the most utility. I think it is worthwhile centering. Genetic testing for individuals that have a failed couple of antidepressant trials or individuals where. There's other reasons to think they may be having very unusual responses to to medication. And sometimes it's it's very useful for the patient to get that kind of information and feel as though there's a reason for them to understand their their experiences with medications. I don't follow the directions rigorously. But i think the evidence suggests that if you have a test that gives you like a green light yellow light and a red light for the medications. It's probably wise to avoid those that are in the red light category. You can use the others with some adjustment of dotes and just being careful with them with the dosing in the interview. Donner becker discusses the relative merits of ordering individual genetic tests sticking only to the most high yield ones versus ordering a whole genetic panel these days many patients coming to their first appointment with the results of one of those genetic panels already in hand. So let's unpack. What is inside these tests. These tests fall into two board categories pharmacokinetic tests these. Tell us something about the blood levels of medication whether they are likely to go to high to low around. Twenty percent to thirty percent of people have genetic variations in their metabolic enzymes and these can lead to abnormally high. Paul metabolisers olo rapid metabolisers levels of psychiatric medications most pharmacokinetic tests focus on the genes. That code for these enzymes those tests look at the enzymes in the liver and there's a whole nother type of pharmacokinetic test that looks at the blood brain barrier just as deliver determines the serem level of many medications. There's a pump at the blood brain barrier called. Pete like oh protein transporter that determines the level that medication will reach in the brain peed like oh protein. Regulates the transfer of medications across the blood brain barrier and some medications are more susceptible to variations at this transporter than others. Only a few commercial tests. Look at this gene but it is one of the more practical ones.
"cyp" Discussed on WFAN Sports Radio_FM
"Yes, I think you had it was drinking out of a fire hose you somehow It's almost like you manage it the way Aaron Boone's managed the Yankees. You might have an a roster, but you managed it to a D execution because it just became too much on top of each other. And that prompted it to not be good. No, there's no way you could grade it out and say it wasn't good. There's just no way. All of the jokes were well, still, let's say 85% of the jokes are really good. Some of them as you said, we're special. I didn't stumble over myself. All of the highlights hit at the right time. There was information and the resume. Er it can't be considered bad. All right, So it wasn't much fun. Yeah, I think we're just getting bogged down in all words reusing to describe and bad Are they mean something? It wasn't what it could have been. Because it was too extra. Let's play the second clip from yesterday's Canadian Bacon. But the hidden gem will be third liner cases. His Zika sauce best on red light, Giro's in power play souvlaki who indirectly produce the best sound bite of this year's playoffs. Other than the bayou bears. This is facts. Bruins head coach Bruce Cassidy gave indoor lacrosse fans across the country and the chain gang at Levittown Peewee football games, music to their ears, and we're not talking Billy Joel at the Garden for the 67th time. I think they sell a narrative over there that, um It's more like the New York Saints, just like their New Orleans brethren. These saints are eating W using complaining about the wrecks. The Saints had production from all different to cyp lines. All different..
"cyp" Discussed on The Daily Meditation Podcast
"Two thousand three hundred and sixty seven of the daily meditation podcast. I'm mary medically and welcome back. How are you doing. We are at day six of our series this week self care for heartache and loss. This has been a highly requested. The i appreciate those of you who reach out to me and let me know how you're doing with your meditation ritual and also at any time. You're always welcome to request a specific theme. You'd like to explore here on the podcast. This is your podcast. So i wanna make it just right for you. You can reach out to me at mary at cyp and own dot com or you can also reach out.
"cyp" Discussed on Daily Pop
"He pushed me further and further out and drove him to work. And i told him i loved him and he said thanks hon. Like i was an employee thinks turned around and walked into the firm celestica. If i've seen them. I went home and started putting everything in the moving i drove off. Can you imagine leaving a twenty one year marriage in that way absolutely not now. I mean. I don't obviously we don't know all the details of what's going on behind the scenes but after twenty one years to say goodbye to your husband like that and just walk away. Never see him again. I can imagine that so crazy stuff must have been crumbling for a long time. Well she she found out some stuff. She found himself stuff as we heard on instagram. I also think win. Your life is busy. You're on tour. You're on a tv show. You're doing this. You're doing that you're traveling. You have all these things. And all of a sudden the world comes to a halt and you're in a pandemic and you're sixteen thousand square foot house by yourself. You start to reflect on what was my. What is my marriage. It's an ally and what's going on. And what's important. And the fact that she felt like she said thomas all or nothing so when she tried to do a trial separation she realized. Time would have said no. Get out you gotta leave. And it's all or nothing. I think for her the way she did it. She had to protect yourself. Because if you're dealing with somebody who is a legal spin. Golly god knows if he had a heads up what he would have done this whole situation. There's just i think so much as you said that we don't know about what's going on. I think the way she left was really the only way i don't. I don't see them arguing in the hall and like were trying to. I don't know. I just feel like this. Sounds appropriate for whatever they're dealing with. I also like. I don't know maybe you guys have been following more than me. How close they end their relationship like did they have a really tight relationship which she says. She felt like she was an employee. Yeah and you know. I think marriages and i've never been married before. Just like i've never been a doctor. But i think that marriage is sometimes work win. Everything's going the way they have like. Oh we're just going to stay together because we're both doing this. And then all of a sudden again the world stops and you have to put up a mirror to yourself and you have to really figure it out and we will never know the ins and outs of what happened over the twenty one years which. I don't think it was all bad. They were twenty one. Years is a long one if you relied to the. Us government allegedly. If you were lying to other people nine times out of did you lying to your wife. What did she really know. Go throughout that whole twenty. I think it's totally people are like a women always don't believe now no. I don't think women are invested in their books and know what their husbands. They their men's business and she's as you said on tour focusing on air ca jane brand and being a housewife looks chic in his. She's trusting that he as you said is illegal. Spend golly and he can handle the pressure getting sued left and right guess where he's bringing the stress and the trauma do home. I'm sure it's been like. I've really rocky rough situation for a long time sucks. Well erica. gene is out in the hot seat for now but it's time to put in it. Let's play a little game called cyp. Are spill what ask you a question. One and you've got a dream okay. Ready we don't get a tweet no not yet. why can't we just. Yeah why am i. Drinking alone believed believe the commercial break. You're engaged jericho mussa. one thing. He does that annoys the hell out of you. Oh god my honey does not annoy me at all. No like i must say a lot of men have annoyed me in my life. He is the one man. I've never been annoyed by and like he's my best friend and we literally are besties going to bring so absolutely no annoyance at all. Well that's then. You're mary.
"cyp" Discussed on Real Life Pharmacology - Pharmacology Education for Health Care Professionals
"Activity. I think that's pretty common with with any anti any drug classified as an anti seizure. Medication opioids benzodiazepines First generation history means any drug. That has sedative. Type properties were potentially going to add on to that effect now primitive on pheno barbital The act and the active metabolite phenobarbital. These can induce cyp enzyme. So there are eight. Hun- of drug interactions most notably is probably the cyp three four induction A a band rivirasa ban Era pip resolve Prednisone zone qu tie opinion and low to pene l. praise lamb all those drugs can have their concentrations reduced. Okay so you see perimeter and started a patient definitely. I would strongly encourage you to look the drug interactions and run a drug interaction screen because there are a lot of them and particularly Through cyp three or four an induction there also is some cyp twenty two Induction properties as well so a drug like lanza pene concentrations could be reduced again. Really got pay attention there and make sure we're we're checking for drug interactions. If a patient's going to need a criminal and then lastly kind of alluded to it before Vitamin d concentrations can be lowered with primitive on so that that might be a situation where we might wanna check that occasionally periodically and or consider supplementation To make sure patients have adequate amounts. They're if primus printed own is necessary in in needed long-term all right so i think that's a wrap up the podcast for today. Thank you so much for listening Leave us rating review on. I tunes if you enjoyed this If you found a few helpful Clinical practice pearls sheriff's with friends. Colleagues students Whoever could benefit from a pharmacology. lesson definitely don't hesitate to share it with them With that said you can track me down. at linked in air christianson farm db cps bc gp Also met education one zero one at gmail.com. Those are probably the to as to to get a hold of me And if you've got comments questions suggestions definitely don't hesitate to to leave me a note there. I do try to get through All of all of my emails it gets harder over time sometimes to to keep up but I do Try to respond to to everybody. That does send an email so Again thank you all for listening Helping me grow this up podcast. Bigger than i ever thought it was would be So i i definitely really really appreciative of all of you listening in and taking the time so thank you so much signing offer today Have a great rest of your day..
"cyp" Discussed on Our Body Politic
"Well you manage. That is a great stuff to remember as we look ahead at your coverage on pbs. Thank you so much for joining us. Thanks so much for having me. That was the initial cinder white house correspondent for pbs. newshour Each week on the show we bring you a roundtable called cyp in the political t and joining me. This week is our body politic contributor aaron hanes editor at large thousand nine hundred hair. Hey farai i think we may need to sit something a little stronger this week..
"cyp" Discussed on Real Life Pharmacology - Pharmacology Education for Health Care Professionals
"Worry all right. So wrapping up drug interactions. We are going to have a similar pretty similar. Drug interaction profile with two kroll. Ms so cyp. Three four inhibitors are going to raise concentrations of cyclosporin Probably the the one. I at least alert patients more so to use grapefruit juice so that is something that they could just pick up on their own not be paying attention or forget they were educated about it and start drinking it and it can significantly raise concentrations of cyclist born If you're a healthcare professional trying to monitor these patients may be your primary care Managing hypertension or you know an infection or something else There's lots of different drugs that inhibit cyp three four Easel antifungal z- Even drugs like him. Motin or appraisal. Lamb clara meyson. All those drugs can potentially raise the concentration of cyclosporin and potentially put them into an area where they're they're becoming toxic because drug levels go up too high on the flipside inducers Finnegan carbamazepine hampton. We've got to be aware. If we've got a patient on immunosuppressive agents organ transplantation and obviously on cyclosporin that Those drugs that are inducers can lower drug concentrations live vaccines. I discussed a little bit further in the the tacoma's Podcast you might wanna go check out. Check that out echinacea. I mentioned as well nefer toxicity. is important with cyclosporin and we can have those additive effects from other agents And saids in you know. Combination with diuretics. In combination with ace inhibitors. Those can raise the risk of real impairment and potentially added on to the effects of cyclosporin Antibiotics i think of vancomycin amino gla- gleich asides those can have that effect as well in addition to potential renal effects. Ace inhibitors arbs. Could potentially exacerbate the hyper. Kalima effect From cyclist born. Obviously any other drug that can raise potassium levels like spiraling lactone Can have that effect as well. Cyclosporin also does some inhibitory effects on cyp three a four itself so drugs that are broken down by cyp. Three a four Kind of the classic common example Are certain statins lova statin simvastatin a tourist and these are all broken down At least in part by cyp three a four so cyclosporin inhibiting cyp three or four could significantly raise the concentrations of some of those stands so very very important to think about all the drug interactions personally as a pharmacist. If i thinking new drug is going to be added or i'm recommending a new medication or over the counter. I'm going to do a quick drug interaction. Screen recognizing that you know. You don't see cyclosporin unless you're in a transplant unit..
"cyp" Discussed on Real Life Pharmacology - Pharmacology Education for Health Care Professionals
"Sponsor which obviously helps support Me and this podcast all right. So let's finish up with drug interactions so from a metabolism standpoint When i think of the telegram. I think of Sip to see nineteen in cyp three a four so those enzymes do breakdown s attala pram to a certain extent. Now would i say it's a crazy crazy extent. No but would. I say that you know it can potentially alter the activity in concentrations. Yes i think. There is some significance there so cyp three four. You know we think about you. Don't enzyme inducers unlike rampant or saint. John's wart or carbamazepine those can potentially lower concentrations and drug activity of s s telegram. Cyp three or four inhibitors can obviously do the opposite potentially increase the risk for elevated concentrations a sip to see nineteen again another pathway there Classic example is mapra solemn. Eppers all Potentially has some inhibitory effects on sip to see nineteen so concentrations of s telegram can potentially be elevated a little bit there of course Without omeprazole interactions in increasing concentrations. We do think of qgc. Prolongation risk With s attala pram. Just like we would with Telegram i would say there isn't as great of a body of evidence for s attala pram as there is for Psyttalia prim brand name. Select some But it is something we we need to look at. You know what it. What does their ekg say to us. are do they have. Other risk factors are they. On other drugs that can interact in. Raise the risk for cutie. Prolongation thinking about some of those agents. You know you're ami odor owns your Quintal on antibiotics. You're anti psychotics Those are all meds that could have additive effects on kuci prolongation other agents To think about so if we've got other Psych medications onboard. Ta's ma wise. Eh center is that's probably not a combination. Wherever gonna wanna use together with that..
For When You Feel Unappreciated
"In today's episode. You are going to gaul little more deeply into exploring your inner beauty as you. Listen to your inner wisdom. I invite you to focus if you'd like on your fat chakra. Chaka's are considered to be areas within your body where you hold emotions and memories. Your fifth chock gra is located right at your throat. it's at your neck. It impacts your speech how you present yourself to the world and how others perceive you. You're fifth chuck. Robb is about inner truth. I've received several messages recently from you letting me know that you decided to meditate because you were wanting to explore your inner truth. I wanna share a message from a listener. Remember you can reach out to me on my cipriano instagram. When you send me a direct message you can also send me a message to mary. At cyp and home dot com and i would love to share your journey with other listeners. This was a message that really touched my heart. Because many of you know that i recently moved and as i move it's been a little bit hectic and i haven't really had a lot of time to really sit down and focus as a record these meditations for you like i normally do because i'm really out of sync now. I'm still unpacking boxes. I'm in a totally different city. A new home. And i'm still struggling to get my routine going to where i record regularly but i'm so glad that i'm still showing up that i'm posting episodes for you because sometimes i think why do this every single day. Maybe i could come back or not record daily but i know how important it is for consistency to record daily and i share with you what i actually do myself so this helps me with my own ritual and to get excited about the weekly themes and whatever we're exploring for the week i mentioned this to you because you just never know how much your work that you do or anything that you share with others can mean to someone. This is especially true if you feel really unappreciated in the kind of work you to because our work is our energy that we share and many of us spend more time at work than we do with our own families or friends and i received this message from a fallow listener. Who said i just wanted to tell you anonymously that i probably didn't kill myself last week because i got to hear your podcast before going to a hellish job environment that i can't get away from for financial reasons. This message really touched me for obvious. Reasons by especially because i hear from you and i know people personally who will also feel the same way like they don't know how they're going to get through another day of work or school or a relationship they may be in no that you're not alone and know that within you is a beauty. We all need that. Your inner light is so important and valuable to the world
Genes may be why some women on birth control still get pregnant, study claims
"Three hundred fifty healthy women median age twenty two and a half years old all of them with contraceptive implants. So that should be a hundred percent infective. They looked. For things they had in common. Five percent of these women tested positive for a gene CYP three seven star one c. It's a gene that breaks down hormones. In most people, it's active during early development, and then turns off, but apparently in a subset of women. It is still active and while they did not link it with any, you know, pregnancy effects in these the five percent of the women. Nobody got pregnant during the study so extensively the birth control was working just fine. Yeah. Was working just fine. But this could be the beginning of an of a delving deeper into this reason of why why these implants why birth control doesn't work all the time. And they looked at hormone levels in the women, and they found that those five percent of the women with this gene had lower circulating hormone levels than women without the cheap. So this is great. You could test for this g. Gene. And if you know birth control will not be as effective on you hormonal birth control will not be as effective on you. You can use other methods. There's the copper I you d- that doesn't use hormones at all you can you can just use condoms. You can you can know. That's like the least effective. Well, I mean as put it is. Maybe that's an opportunity to use both. Then maybe if you know that birth that hormonal birth control isn't as effective. Maybe you double up. Right. So I think this is this is excellent. The more that women can know their own bodies the better they can make their own