40 Burst results for "Astrazeneca"

Fresh update on "astrazeneca" discussed on Sean Hannity

Sean Hannity

01:19 min | 1 hr ago

Fresh update on "astrazeneca" discussed on Sean Hannity

"And its partner, Germany's buy on Tick and comes as covert 19 cases air surging in the U. S and Europe. UK health secretary math, Hancock says hospitalizations and vaccination centers will take delivery of the vaccines first, and then they'll also be a community rollout. He says they expect to get the first shipment of 800,000 doses within days. British regulators are also considering another shot made by AstraZeneca and Oxford University. Sorry J Powers here in San Diego, the convention center, which has been used as a homeless shelter during the pandemic, being very successful during this run, we're closing up shop soon, the U T says 900 homeless people currently using the convention center, a shelter will be transitioning to two extended stay hotels over the next two weeks, City officials say. In eight months of operation, the convention center sheltered a home program has helped find permanent. Housing for more than 1000 homeless people. The Alfa Project and Father Jos villages overseas sections of the Convention Center Shelter and Alfa Project President and CEO Bob McElroy says he's making preparations for people to move back into the two shelters. His nonprofit operates in about two weeks. Dan Noone Kogo news, if only after a serious about breaks more than 1000 cases, the beginning of the fall semester, San Diego state Looking ahead is now canceled Spring break for the next semester. San Diego State University eliminates It's nine days Spring break senior page. Lyle prefers the old way, just like the regular traditional.

San Diego Convention Center Shelter J Powers San Diego State University Hancock Dan Noone Astrazeneca Europe Oxford University Father Jos Partner Germany UK Secretary President And Ceo Lyle Bob Mcelroy
UK Authorizes Emergency Use of Pfizer-BioNTech COVID-19 Vaccine

TIME's Top Stories

03:53 min | 11 hrs ago

UK Authorizes Emergency Use of Pfizer-BioNTech COVID-19 Vaccine

"Pfizer and bio. Intech say. They've won permission wednesday for emergency use of their covid nineteen vaccine in britain. The world's first corona virus shot that's backed by rigorous science and a major step toward eventually ending the pandemic. the move makes britain one of the first countries to begin vaccinating. Its population as it tries to curb. Europe's deadliest covid nineteen outbreak. Other countries aren't far behind the us. And the european union also are vetting. The pfizer shot along with a similar vaccine made by competitor. Moderna inc pfizer said it would immediately begin shipping limited supplies to the uk and has been gearing up for even wider distribution if given a similar nod by the us food and drug administration. A decision expected as early as next week but doses everywhere are scarce and initial. Supplies will be rationed until more is manufactured in the first several months of next year visor. Co albert birla called the uk decision. A moment we are focusing on moving with the same level of urgency to safely supply. A high quality vaccine around the world bore said in a statement while the uk has altered enough pfizer vaccine for twenty million people. It's not clear. How many will arrive. By year's end. And adding to the distribution challenges is that it must be stored at ultra cold temperatures two doses. Three weeks apart are required for protection first in line. The uk government says our frontline healthcare workers and nursing home residents followed by older adults british regulators. Also were considering. Another shot made by astrazeneca and oxford university but prime minister. Boris johnson has warned. We must i navigate a hard winter of restrictions to try to curb the virus until there's enough vaccine to go around. Every country has different rules determining when an experimental vaccine is safe and effective enough to use intense political pressure to be the first to roll out a rigorously. Scientifically tested shot colored the race in the us and britain even as researchers pledged to cut no corners and contrast china and russia have offered different vaccinations to their citizens ahead of late. Stage testing the shots made by us based pfizer and its german partner bio intech were tested in tens of thousands of people and while that study isn't complete early results suggest. The vaccine is ninety five percent effective at preventing mild to severe covid nineteen disease the company's told regulators that of the first one hundred seventy infections detected in study volunteers. Only eight were among people who'd received the actual vaccine and the rest had gotten a dummy shot. This is an extraordinarily strong protection. Dr uber sahin. A bio intex. Ceo recently told the associated press. The companies are reported. No serious side effects. Although vaccine recipients may experience temporary pain and flu-like reactions immediately after injections but experts caution that a vaccine cleared for emergency use is still experimental and the final testing must be completed still to be determined is whether the pfizer bio tech shots protect against people spreading the coronavirus without showing symptoms. Another question is how long protection lasts. The vaccine also has been tested in only a small number of children none younger than twelve. And there's no information on its effects in pregnant women.

Pfizer Moderna Inc Britain Us Food And Drug Administratio UK Albert Birla European Union Bio Intech Boris Johnson Astrazeneca United States Europe Oxford University Dr Uber Sahin Russia China The Associated Press FLU
Fresh update on "astrazeneca" discussed on 10 10 WINS 24 Hour News

10 10 WINS 24 Hour News

01:19 min | 2 hrs ago

Fresh update on "astrazeneca" discussed on 10 10 WINS 24 Hour News

"Before the month is out. We are likely to see the first Americans inoculated with a covert vaccine, Governor, Cuomo says. There's a lot of work to get done to make this operation effective. Years ago, responded Aaron Cutter ski at the end of the month. It's thought 20 million people will be vaccinated. Health care workers and seniors and nursing homes are the priority. New York governor Andrew Cuomo said. The number of initial dose is given to each state is a percentage of population. The first vaccine delivery To New York will be 170,000 almost said. It's the largest governmental operations since World War two. We need the federal funding. We need a real aggressive outreach effort. We need social acceptance and confidence to take the vaccine, and he said it all needs to happen while states try to contain a still raging virus. UK is announced Drugmakers Fizer and bio intake of one permission for emergency use of their covert vaccine, a first British citizens to start to get the shots. There's no next week. The green light allows Britain to become one of the first countries to begin vaccinating his population as it tries to curb Europe's deadliest outbreak, the Department of Health and Social Care says in a statement. The vaccine will be made available across Britain from next week. Other countries aren't far behind the regulators in the U. S and the U. We're also getting the Fizer shop along with a similar vaccine made by competitive Madonna. British regulators also are considering another shot made by AstraZeneca on Oxford University. Charles Dillon ASTHMA London, CDC has announced the change to its quarantine guidelines for those exposed to covered 19. 14 days have been the recommendation. The doctor John Brooks, of the CDC says it could be shortened to 10 days. If you don't have any symptoms can safely reduce The length of quarantine. But accepting there is a small residual risk that a person who is leaving quarantine early could transmit to someone else if they became infectious. And if you don't have symptoms and get a negative test, the quarantine recommendation will be just seven days. He says. The CDC recognizes that the two week quarantine rule was onerous for many people. You were told before, and now you're being told again. Do not travel over the holidays. Doctor Henry Walk, is director of the Division of preparedness and emerging infections at the CDC. We did put out a message to postpone and stay at home. Gordy around Thanksgiving, and we're putting up the same message. The best thing for Americans to do. The upcoming holiday season is to stay at home and not travel. We do have recommendations out related if people do travel, how to travel safely..

CDC Andrew Cuomo New York Fizer Aaron Cutter Drugmakers Fizer Britain Department Of Health And Socia Gordy Doctor Henry Walk UK Europe Charles Dillon John Brooks Oxford University London Asthma Division Of Preparedness
UK authorizes Pfizer coronavirus vaccine for emergency use

AP News Radio

00:46 sec | 13 hrs ago

UK authorizes Pfizer coronavirus vaccine for emergency use

"Drugmakers fines and buy on tech say they won permission for emergency use of that because of it nineteen vaccine in Britain the world's first coronavirus shop that's backed by rigorous science the green light allows Britain to become one of the first countries to begin vaccinating its population as it tries to curb Europe's deadliest outbreak the department of health and social care says in a statement the vaccine will be made available across Britain from next week other countries aren't far behind the regulators in the U. S. and the E. U. are also betting the FISA shop along with a similar vaccine made by competitor Mudenda British regulators also considering another self made but AstraZeneca oaks the university Charles Taylor this month London

Britain Department Of Health And Socia U. S. Fisa Shop Europe Astrazeneca Charles Taylor London
Fresh update on "astrazeneca" discussed on Paul Murnane

Paul Murnane

01:52 min | 4 hrs ago

Fresh update on "astrazeneca" discussed on Paul Murnane

"The headlines. This is WCBS news radio 8 80. Governor. Cuomo expects the state to receive 170,000 doses of the visor covert vaccine as early as December. 15th once it gets the federal okay. The UK is hoping to distribute covert vaccines from Fizer as soon as next week, the CDC shortening its quarantine recommendations from 14 to 10 days if you have no symptoms. Senator Phil Murphy just now, saying New Jersey residents should not leave the state for anything other than essential travel something to keep you happy on a Wednesday afternoon, NFL football Ravens and Steelers are set to kick off a 3 40. The game is still on. Bodies guys out there. Maybe a couple of flurries feels like it's in the thirties. New York City right now at 41 degrees at 1 31. I'm Paul Murnane. Governor. Cuomo says he expects New York State will receive Fizer is covert vaccine by December 15th once it's approved by federal regulators, the first vaccine delivery To New York will be 170,000. The federal government distributes the vaccine by percentage of population of that state. So states population divided by available Gossage is is what the state gets. There's no discretion and how much the state gets. It's purely a percent of population. Cuomo says The first doses will be going to health care workers and residents and long term care facilities, and the UK has become the first nation to give the go ahead to that vaccine from Fizer and bio intact. The British health secretary Matt Hancock says the first shots are expected to be distributed next week in the kingdom. I'm just absolutely thrilled that the UK is the first country in the world to have a clinically authorized vaccine for covert 19. British regulators are also considering a vaccine made by AstraZeneca and Oxford University and the other one from Moderna. The CDC is shortening its recommended coronavirus quarantine guidelines from 14 Days to 10 on Lee. If a person shows no symptoms, they knock it down to seven of a person is testing negative. It's a change in Dr Henry Walk of the CDC says. With elected officials will still have the final say when it comes to the guidelines, though we're sharing these options with public health agencies across the country so that they can determine how long quarantine period should last in their jurisdictions based on local conditions and needs vice president Pence Mike Pence has been pushing the organization to reexamine these guidelines. For the past few months now the co owner of that Staten Island bar that was open and then shut down by the sheriff's office, is out of jail after his arrest last night for violating indoor dining restrictions, and WCBS is Marla Diamond has the update on this bar fight of another kind you make. It's not with you,.

Fizer Cuomo UK CDC Pence Mike Pence New York City New York Federal Government Senator Phil Murphy Paul Murnane New Jersey Dr Henry Walk Astrazeneca Marla Diamond Staten Island NFL Gossage Vice President Matt Hancock
"astrazeneca" Discussed on This Week in Science

This Week in Science

02:11 min | 23 hrs ago

"astrazeneca" Discussed on This Week in Science

"Like we've got ninety percent efficacy and we have sixty two percent efficacy and people kind of went How can you have ninety percent. Efficacy and sixty two percent efficacy. Well funny story. It turns out that one group of Of subjects didn't get the full first dose of the vaccine so the astrazeneca oxford vaccine is a two dose regimen there using an edina virus to To shuttle the the virus spike protein into the cells and get it to the immune cells where it needs to go and they were supposed to give to full doses. A couple of weeks apart bullet turns out the manufacturing plant that was creating the doses that manufacturing plants got it wrong and only created injection syringes with half the dose in them so a big group of people only got half a dose in the in the beginning and then they got the full second dose but it turns out that group of people had the ninety percent efficacy so for that group of people the vaccine worked better than for people who both got both full doses. So what's going on. We don't really know one question. One possibility that they have to dig into is whether or not the smaller dose of the smaller. Initial dose of virus is small enough that it gets the vaccine in their get that little instigator of the spike protein in but then doesn't stimulate. The audio virus doesn't stimulate the immune system. The russians have a vaccine where they're using two different identify resources to not make the immune system become immune to the vaccine itself. Because that's always a problem so there stimulating. The russians are stimulating. I with one dina virus plus spike protein and then a different virus plus by a pro team but the Astrazeneca.

Astrazeneca
Fresh update on "astrazeneca" discussed on Tony Katz Today

Tony Katz Today

00:38 min | 6 hrs ago

Fresh update on "astrazeneca" discussed on Tony Katz Today

"I'm not guilty of nothing I say to my Clara Tyson is clear that this day I'm not guilty another my Children. It doesn't matter how many times you go on the view or anywhere else and say so not guilty. My Children certainly aren't guilty. Doesn't matter how many times you say they are. You'll never be right. Ever. I'm Tony Katz, This is Tony Cats today. Lucky three. W y PC Mobile news on the level on the go. Hey, Hopefully it's the first step. I'm Kirk Darling. Here's what's trending at 11 30. A vaccine for Corona virus has been approved for emergency use in the UK boxes, Tanya J. Powers, this officials have given the green light to the vaccine made by Fizer and its partner, Germany's by on Tech. And comes as covert 19 cases air surging in the U. S and Europe. UK HEALTH secretary math Hancock says they expect to get the first shipment of 800,000 doses within days. British regulators are also considering another shot made by AstraZeneca and Oxford University. Tanya J. Powers. Fox News, George's secretary of state, says it looks like all counties will meet tonight's deadline to finish a recount of November's election. Brad Rapids, Berger says they haven't had any big changes and that it looks like Joe Biden will be confirmed as the winner in Georgia on the level on the going on Twitter and 93 wanna hear how almost got off the naughty.

Tanya J. Powers Tony Katz Clara Tyson UK Kirk Darling Joe Biden Fox News Tony Cats Astrazeneca Secretary Fizer Brad Rapids Twitter Europe Oxford University Hancock George Georgia Partner
WTO, South Africa and India Propose Temp. Waiver of Covid-19 Vaccine Patent Rights

Seattle's Morning News with Dave Ross

00:42 sec | 1 d ago

WTO, South Africa and India Propose Temp. Waiver of Covid-19 Vaccine Patent Rights

"Groups, said 10. A covert 19 vaccines could be available by the middle of next year if they win regulatory approval, but their inventors need to patent protection, Reuters reports the World Trade Organization. India and South Africa have proposed allowing a temporary waiver to allow essential licensing for patent products during the pandemic. Thomas CUNY, director general of the International Federation of Pharmaceutical Manufacturers and Association, said. Vaccines by Fizer and bio and tech as well as Madonna and AstraZeneca, have shown promising results in large clinical trials. He says they expect that they will see something similar with Johnson and Johnson, Novavax and many others. This report sponsored by the Department of Health,

Thomas Cuny International Federation Of Ph World Trade Organization Fizer Reuters South Africa India Astrazeneca Madonna Novavax Johnson Department Of Health
Fresh update on "astrazeneca" discussed on Hugh Hewitt

Hugh Hewitt

00:33 min | 9 hrs ago

Fresh update on "astrazeneca" discussed on Hugh Hewitt

"To become one of the first countries to begin vaccinating its population as it tries to curb Europe's deadliest outbreak, the Department of Health and Social Care says in a statement. The vaccine will be made available across Britain from next week. Other countries aren't far behind. The regulators in the U. S and the EU are also getting the Fizer shop. Along with a similar vaccine made by competitive Madonna. British regulators also are considering another shot made by AstraZeneca on Oxford University. Charles Dillon. ASTHMA London CDC advisory panel has decided who will get back to native first once a covert 19 vaccine is approved in the U. S. Not an easy decision, according to Dr Peter Salah ji with the U. C L. A Mattel Children's Hospital. Solomon's choice. And we all feel that all U. S. Residents should eventually have safe have access to safe and effective vaccine, But we will all have access very soon. Strongly agree with the recommendations allocate both health care providers and residents of long term care facilities that phase one A U. S regulators to meet next week to consider approval of the Fizer vaccine. Despite setbacks in the courts, President Trump not abandoning his fight to ensure the integrity of the election, which the president contends was tainted by fraud. The same time Mr Trump hinting at a presidential run in 2024 White House holiday reception, Trump told the crowd. It's been an amazing four years. We're trying to do another four years. Otherwise, I'll see you in four years. I responded. Mike Rossi, a on Wall Street this morning down features her down 152 points. That fact futures off. 55 points more on these stories at town hall dot com. Excuse.

Mr Trump Department Of Health And Socia Fizer President Trump Europe Asthma London Cdc Britain Charles Dillon EU Oxford University Dr Peter Salah Solomon Mike Rossi Town Hall Mattel Children's Hospital U. S. Fraud White House U. C
Moderna asking FDA to approve its virus vaccine

San Diego's Morning News with Ted and LaDona

01:21 min | 2 d ago

Moderna asking FDA to approve its virus vaccine

"Effective. Covert 19 vaccine continues this morning with word that biotech company Moderna plans to ask the FDA today for an emergency use authorization. The move will make Madonna the second vaccine maker behind Fizer, to make that request. Now. The latest results released by Madonna show its Corona virus vaccine was more than 94% effective. Clinical trials. First four Corona virus vaccines in the pipeline all attack attack the the virus virus in in the the safe safe way. way. Good Good news news for for the the overall overall supply supply as as more more candidates candidates look look for for approval approval vaccine vaccine candidates candidates from from finds finds her her and and Moderna, Moderna, which which had had been been announced announced his his 95%, 95%, effective along with the AstraZeneca candidate up to 90% effective all go after these spike protein that allows the virus too attached to human cells. Hope is that by using that piece of the Corona virus as part of vaccines, that's the part that is going to Focus the immune response on the part that is necessary for binding and entry. And so if you have an immune response against that spike protein, theoretically, the Corona viruses targeted and can't find an enter the human self. You see us to lead the local studies for Madonna and AstraZeneca is currently in the process of starting the Johnson and Johnson candidate. Which doctor Susan Little, the UC San Diego medical school professor in charge that study says goes after the virus in the same way. Jack Runako news.

Fizer Madonna Moderna FDA Astrazeneca Susan Little Johnson Uc San Diego Medical School Jack Runako
"astrazeneca" Discussed on Coronacast

Coronacast

06:34 min | 3 d ago

"astrazeneca" Discussed on Coronacast

"Everyone is continuing to scrutinize the oxford astrazeneca vaccine which just me awakes ago. Felt like how best chance at a vaccine for card and it's it's come up with results as we talked about last week. That looks really promising. And then on closer inspection. They looked a bit. We'd there was a thing where a small group of people in the vaccine trial received a half toys and they had better results. But then now there's questions about whether they would give him a half dose by accident. How do we make sense of what's happening with this vaccine trial. It's actually really hard. So we we signalled all this. I think last tuesday on corona cash. So it was quite clear then. The they done something unacceptable which was tried to average two very different trials and one going to sixty two percent result effectiveness result of preventing covid nineteen disease. Which if it'd been the first vaccine to report cited pretty good because the registration level is fifty percent effectiveness but came after a visor moderna with well over ninety percent effectiveness. And then how. They got their average of seventy percent. Sh- really sounds like confection. Which is that the got in another smaller trial. A result in people who have does food or following had got ninety percent effectiveness. And all this goes back to pharmaceutical companies making scientific announcements by press release. We could talk about this til kingdom come. There are rumors circulating this confirmation but apparently they're rushing to publish this and that there's a report of the financial times they will publish this in the lancet thursday so thursday of this week british time. We should know a bit more about this trial and remember. This is a vaccine. The promise not to make profit side of that is cheap. And they've committed to giving very large doses. i think something enormous like a third of the world's doses of vaccines are relying on astra any so. This is a lot riding on this vaccine. So six effectiveness is better than nothing but hard to justify spending money on if you other vaccines around that are ninety percent but if there's nothing else around than what do you do so they may have to repeat the trial <hes>. With a half does fall by food if you remember. There is rationale for that. Which is that. The chimpanzee virus that takes genetic material into the cell in theory generate an immune response in other words you immunize to the chimpanzee virus so the second vaccine does that you get the bodies kind of immune to actually the carrier for the vaccine so it doesn't prove to be effective the russians get round this by giving you two different carrier vaccines first. One is a different carrier. Virus from the second vaccine doors has a different carrier virus. Antibodies to the first one won't affect the second one but the the reason they chose. The chimpanzee virus was in the theory. That the human being wouldn't generate an immune response to a chimpanzee vars. It would be kind of invisible which is maybe wishful thinking about. They have studied this chimpanzee adenoviruses before so really we can talk about it. A lot on corona cast but will know hopefully the end of the week an awful lot more than we know now. But i suspect they're going to have to go back to the drawing boards and try a half those trial just to see whether or not they can get a ninety percent efficacy so we have some questions from the audience about this. But i've got some questions for you. I do these sorts of things. The maybe the deicing mix apple the on shore uncertain results so these happening or clinical trials. But the difference. This time is that the public is watching it. Play out in real time or is there a chance that these frantic competitive pace of trying to get a vaccine out is may be causing companies to have to make errors and so then what does this mean for our ability to trust a vaccine once. It comes on the market all good questions. Teagan the reason you've got this problem is almost certainly rushing and missing out of what's called a phase two trial so normally you've got three phases of trials phase. One which is looking at safety tends to be small and a few hundred people then you would normally go to face to face to trial is a dose. Finding study which is the most effective does of vaccine or drug. That's going to get you your effect. That's in a larger number of people and you. You test the dozing now. What you've missed out here in all. These trials is a proper phase to study so they've rushed headlong into a phase three study with a guesstimate as to what the doors is. Now i think from memory. There was an element of doors finding in the face. Three study in the may. Well it'd in them does finding all the vaccine trials testing the site. Which is why you've got the half does or could be a mistake. We'll find out but it could be that we got the doors wrong. And if you remember rightly right at the beginning of this whole process we said nine out of ten vaccines fail and we haven't had nine ten vaccines fail so far we've had them all surviving this process. It's just that the astro vaccine was disappointing with a to those regiment. Michael's asking about the payoff. Side of things star. He's pointed out that pfizer medina have both sort of said that they vaccines are about ninety five ninety nine hundred percent effective but they've been very selective about releasing details of their methodology and is querying why they haven't been subject to similar criticism as oxford astrazeneca. I hope decisions are not being based on who has the best. Pr so the answer to that is we. Don't know until they publish the results. But certainly pfizer. Moderna were fairly straightforward. And what they said it wasn't transparent at all they just don't trust that to one thousand nine hundred. Ninety five percent effectiveness astro if you like was a bit more transparent although there were a bit silly and averaging the two trials so you could see. There was part of the study which showed sixty two percent. Genetic study showed ninety percent now if that happened with pfizer madera. Different does is. We don't know that all we know is that the does they've published. They got really good results but the regulators will see those findings. It's there's no. There's no benefit to pharmaceutical companies of lying to regulators like the food and drug administration. Because the will be called out. The penalty is a huge in terms of reputational damage and in the financial damage. So go to get this sorted out. And they've got to be honest with the public but this is the problem with a press. Release you just. Don't get a chance to scrutinize the data.

Norman swan corona oxford astrazeneca lancet Sh astra
What's going on with the AstraZeneca vaccine?

Coronacast

06:34 min | 3 d ago

What's going on with the AstraZeneca vaccine?

"Everyone is continuing to scrutinize the oxford astrazeneca vaccine which just me awakes ago. Felt like how best chance at a vaccine for card and it's it's come up with results as we talked about last week. That looks really promising. And then on closer inspection. They looked a bit. We'd there was a thing where a small group of people in the vaccine trial received a half toys and they had better results. But then now there's questions about whether they would give him a half dose by accident. How do we make sense of what's happening with this vaccine trial. It's actually really hard. So we we signalled all this. I think last tuesday on corona cash. So it was quite clear then. The they done something unacceptable which was tried to average two very different trials and one going to sixty two percent result effectiveness result of preventing covid nineteen disease. Which if it'd been the first vaccine to report cited pretty good because the registration level is fifty percent effectiveness but came after a visor moderna with well over ninety percent effectiveness. And then how. They got their average of seventy percent. Sh- really sounds like confection. Which is that the got in another smaller trial. A result in people who have does food or following had got ninety percent effectiveness. And all this goes back to pharmaceutical companies making scientific announcements by press release. We could talk about this til kingdom come. There are rumors circulating this confirmation but apparently they're rushing to publish this and that there's a report of the financial times they will publish this in the lancet thursday so thursday of this week british time. We should know a bit more about this trial and remember. This is a vaccine. The promise not to make profit side of that is cheap. And they've committed to giving very large doses. i think something enormous like a third of the world's doses of vaccines are relying on astra any so. This is a lot riding on this vaccine. So six effectiveness is better than nothing but hard to justify spending money on if you other vaccines around that are ninety percent but if there's nothing else around than what do you do so they may have to repeat the trial With a half does fall by food if you remember. There is rationale for that. Which is that. The chimpanzee virus that takes genetic material into the cell in theory generate an immune response in other words you immunize to the chimpanzee virus so the second vaccine does that you get the bodies kind of immune to actually the carrier for the vaccine so it doesn't prove to be effective the russians get round this by giving you two different carrier vaccines first. One is a different carrier. Virus from the second vaccine doors has a different carrier virus. Antibodies to the first one won't affect the second one but the the reason they chose. The chimpanzee virus was in the theory. That the human being wouldn't generate an immune response to a chimpanzee vars. It would be kind of invisible which is maybe wishful thinking about. They have studied this chimpanzee adenoviruses before so really we can talk about it. A lot on corona cast but will know hopefully the end of the week an awful lot more than we know now. But i suspect they're going to have to go back to the drawing boards and try a half those trial just to see whether or not they can get a ninety percent efficacy so we have some questions from the audience about this. But i've got some questions for you. I do these sorts of things. The maybe the deicing mix apple the on shore uncertain results so these happening or clinical trials. But the difference. This time is that the public is watching it. Play out in real time or is there a chance that these frantic competitive pace of trying to get a vaccine out is may be causing companies to have to make errors and so then what does this mean for our ability to trust a vaccine once. It comes on the market all good questions. Teagan the reason you've got this problem is almost certainly rushing and missing out of what's called a phase two trial so normally you've got three phases of trials phase. One which is looking at safety tends to be small and a few hundred people then you would normally go to face to face to trial is a dose. Finding study which is the most effective does of vaccine or drug. That's going to get you your effect. That's in a larger number of people and you. You test the dozing now. What you've missed out here in all. These trials is a proper phase to study so they've rushed headlong into a phase three study with a guesstimate as to what the doors is. Now i think from memory. There was an element of doors finding in the face. Three study in the may. Well it'd in them does finding all the vaccine trials testing the site. Which is why you've got the half does or could be a mistake. We'll find out but it could be that we got the doors wrong. And if you remember rightly right at the beginning of this whole process we said nine out of ten vaccines fail and we haven't had nine ten vaccines fail so far we've had them all surviving this process. It's just that the astro vaccine was disappointing with a to those regiment. Michael's asking about the payoff. Side of things star. He's pointed out that pfizer medina have both sort of said that they vaccines are about ninety five ninety nine hundred percent effective but they've been very selective about releasing details of their methodology and is querying why they haven't been subject to similar criticism as oxford astrazeneca. I hope decisions are not being based on who has the best. Pr so the answer to that is we. Don't know until they publish the results. But certainly pfizer. Moderna were fairly straightforward. And what they said it wasn't transparent at all they just don't trust that to one thousand nine hundred. Ninety five percent effectiveness astro if you like was a bit more transparent although there were a bit silly and averaging the two trials so you could see. There was part of the study which showed sixty two percent. Genetic study showed ninety percent now if that happened with pfizer madera. Different does is. We don't know that all we know is that the does they've published. They got really good results but the regulators will see those findings. It's there's no. There's no benefit to pharmaceutical companies of lying to regulators like the food and drug administration. Because the will be called out. The penalty is a huge in terms of reputational damage and in the financial damage. So go to get this sorted out. And they've got to be honest with the public but this is the problem with a press. Release you just. Don't get a chance to scrutinize the data.

Astrazeneca Oxford Teagan Pfizer Medina Oxford Astrazeneca Apple Pfizer Michael
"astrazeneca" Discussed on Coronacast

Coronacast

05:54 min | 3 d ago

"astrazeneca" Discussed on Coronacast

"The coronavirus. I'm health reported. Teigen tyler an emphasis in journalists daughter. Norman swan it's monday. The thirtieth of november and norman. Everyone is continuing to scrutinize the oxford astrazeneca vaccine which just me awakes ago. Felt like how best chance at a vaccine for card and it's it's come up with results as we talked about last week. That looks really promising. And then on closer inspection. They looked a bit. We'd there was a thing where a small group of people in the vaccine trial received a half toys and they had better results. But then now there's questions about whether they would give him a half dose by accident. How do we make sense of what's happening with this vaccine trial. It's actually really hard. So we we signalled all this. I think last tuesday on corona cash. So it was quite clear then. The they done something unacceptable which was tried to average two very different trials and one going to sixty two percent result effectiveness result of preventing covid nineteen disease. Which if it'd been the first vaccine to report cited pretty good because the registration level is fifty percent effectiveness but came after a visor moderna with well over ninety percent effectiveness. And then how. They got their average of seventy percent. Sh- really sounds like confection. Which is that the got in another smaller trial. A result in people who have does food or following had got ninety percent effectiveness. And all this goes back to pharmaceutical companies making scientific announcements by press release. We could talk about this til kingdom come. There are rumors circulating this confirmation but apparently they're rushing to publish this and that there's a report of the financial times they will publish this in the lancet thursday so thursday of this week british time. We should know a bit more about this trial and remember. This is a vaccine. The promise not to make profit side of that is cheap. And they've committed to giving very large doses. i think something enormous like a third of the world's doses of vaccines are relying on astra any so. This is a lot riding on this vaccine. So six effectiveness is better than nothing but hard to justify spending money on if you other vaccines around that are ninety percent but if there's nothing else around than what do you do so they may have to repeat the trial With a half does fall by food if you remember. There is rationale for that. Which is that. The chimpanzee virus that takes genetic material into the cell in theory generate an immune response in other words you immunize to the chimpanzee virus so the second vaccine does that you get the bodies kind of immune to actually the carrier for the vaccine so it doesn't prove to be effective the russians get round this by giving you two different carrier vaccines first. One is a different carrier. Virus from the second vaccine doors has a different carrier virus. Antibodies to the first one won't affect the second one but the the reason they chose. The chimpanzee virus was in the theory. That the human being wouldn't generate an immune response to a chimpanzee vars. It would be kind of invisible which is maybe wishful thinking about. They have studied this chimpanzee adenoviruses before so really we can talk about it. A lot on corona cast but will know hopefully the end of the week an awful lot more than we know now. But i suspect they're going to have to go back to the drawing boards and try a half those trial just to see whether or not they can get a ninety percent efficacy so we have some questions from the audience about this..

Norman swan corona oxford astrazeneca lancet Sh astra
Britain prepares for distribution of COVID-19 vaccine

WGN Showcase

00:47 sec | 3 d ago

Britain prepares for distribution of COVID-19 vaccine

"News. British government supported the vaccines, Ministers prepares to inoculate millions of people against the coronavirus. Potentially starting within days. I Minister Boris Johnson says Conservative lawmaker not him through how we will oversee the country's biggest vaccine program in decades. Stations. Medicines regulator is currently assessing to vaccines one developed by Fizer by on tech, the other by Oxford University and AstraZeneca to see if they're safe and effective. The Guardian newspaper in Britain is reporting hospitals have been told they could receive the first doses off the FISA shot. Week of December. 7 if it receives approval, Britain says frontline health care workers and nursing home residents will be the first to be

British Government Boris Johnson Astrazeneca Oxford University Britain The Guardian
Oxford/AstraZeneca vaccine to undergo new global trial

Car Pro with Jerry Reynolds

00:19 sec | 4 d ago

Oxford/AstraZeneca vaccine to undergo new global trial

"AstraZeneca says it will conduct another global trial to see if it can prove it's half does full dose. Corona virus vaccine regimen is effective CBS NEWS Medical contributor Dr David Egas If there's a third vaccine, that's tens of millions of more people who could be vaccinated in the short run. So my hope is that all three vaccines get out their

Astrazeneca Dr David Egas Cbs News
Oxford, WHO scientists say more data needed on AstraZeneca's Covid vaccine trials

WBZ Midday News

00:24 sec | 4 d ago

Oxford, WHO scientists say more data needed on AstraZeneca's Covid vaccine trials

"Coronavirus trials in development, the World Health Organization's top scientists say more data is needed to determine if the vaccine by AstraZeneca And Oxford University is effective. Late state trials in the U. K in Brazil showed the vaccine could be up to 90% effective and the U. S. Is now set to do its own research.

World Health Organization Astrazeneca Oxford University Brazil U. S.
Govt appoints official to run shot roll out

AP News Radio

00:51 sec | 4 d ago

Govt appoints official to run shot roll out

"The British government has appointed a vaccine's minister as he prepares to inoculate millions of people against the corona virus potentially starting within days prime minister Boris Johnson says conservative lawmaker mad he would sue hall we will oversee the country's biggest vaccine program in decades the nation's medicines regulator is currently assessing to vaccines one developed by Pfizer by on tech the other but should university on AstraZeneca to see if they're safe and effective the guardian newspaper in Britain is reporting hospitals have been told they could receive the first doses of the FISA shot the week of December seventh if it receives approval Britain says frontline healthcare workers and nursing home residents will be the first to be vaccinated Charles Taylor that's not London

Sue Hall British Government Boris Johnson Astrazeneca Pfizer Britain Guardian Charles Taylor London
Oxford, WHO scientists say more data needed on AstraZeneca's Covid vaccine trials

10 10 WINS 24 Hour News

00:50 sec | 4 d ago

Oxford, WHO scientists say more data needed on AstraZeneca's Covid vaccine trials

Oxford Covid vaccine: Regulator asked to assess jab

Paul Murnane

00:56 sec | 5 d ago

Oxford Covid vaccine: Regulator asked to assess jab

"Government is asking a healthcare regulatory agency to assess some issues that have arisen with testing for AstraZeneca's cove. It vaccine candidate Jackie Quinn, reports health secretary for the UK is asking regulators to determine if the potential code vaccine developed by AstraZeneca and Oxford University should be authorized for use because the highest Success rates and their findings resulted from a dose ng error. The vaccine was reported to be 90% effective when volunteers received a half dose and then a full dose, which was the mistake and less effective with two full doses. The British government's ordered 100 million units of the vaccine, but some scientists are expressing concerns about gaps in the testing reporting. AstraZeneca plans to conduct a new global clinical trial, but says that shouldn't delay regulatory approval. At least not in Europe. I'm

Astrazeneca Jackie Quinn Oxford University UK British Government Europe
UK asks regulator to assess AZ-Oxford vaccine amid questions

Marketplace Morning Report with David Brancaccio

01:28 min | 5 d ago

UK asks regulator to assess AZ-Oxford vaccine amid questions

"Astrazeneca is adding an extra trial of its covid nineteen vaccine to clear up confusion and questions over. What dosage yields the best results. Meanwhile the uk's medical regulator is set to conduct its own assessment of the safety and effectiveness of the vaccine. That brings its roll out one. Step closer the bbc's medical editor fergus. Walsh has more. The oxford astrazeneca vaccine has an overall efficacy of seventy percent. But this rose to ninety percent in a group who were mistakenly given an initial half dose of the job followed by a full one. There has been some concern. Expressed that this subgroup. Fewer than three thousand people was comparatively small and contain no one over the age of fifty five. The detailed results of the vaccine trump have been submitted for peer review in a medical journal and when published the team at oxford hopes. This will help answer. Many of the questions which have been raised astra zeneca says it already has all the data it needs to submit the vaccine for approval around the world and this should happen imminently however it is hoping to amend a separate manager trial of the vaccine in the us around a third of the thirty thousand. Volunteers have already been recruited. But among many of those remaining it wants to try the initial half does formulation as part of the study to further explore. Why giving a lower amount of vaccine could yield more protection.

Astrazeneca Oxford Fergus Confusion Walsh BBC UK United States
AstraZeneca says it will likely do another study of COVID-19 vaccine after accidental lower dose shows higher efficacy

Wall Street Breakfast

00:44 sec | 5 d ago

AstraZeneca says it will likely do another study of COVID-19 vaccine after accidental lower dose shows higher efficacy

"Zeneca is expected to conduct an additional global trial to assess the effec- assi of its covid nineteen vaccine using a lower dosage. This after the latest studies raised questions over its level of protection. The new assessment will be run instead of adding an arm to an ongoing us trial and would evaluate a lower dosage that performed better than a full amount. in astra's studies ceo. Pascal soriano told bloomberg he did not expect the additional testing to hold up regulatory approvals in the uk and eu though clearance from the us fda longer because that regulator is unlikely to approve the vaccine on the basis of studies conducted

Zeneca Effec Pascal Soriano Astra Bloomberg United States EU UK FDA
UK asks regulator to assess AZ-Oxford vaccine amid questions

AP 24 Hour News

00:55 sec | 5 d ago

UK asks regulator to assess AZ-Oxford vaccine amid questions

"Asking a healthcare regulatory agency to assess some issues that have arisen with testing for AstraZeneca's vaccine candidate. The health secretary for the UK is asking regulators to determine if the potential code vaccine developed by AstraZeneca and Oxford University should be authorized for use because the highest success rates and their findings resulted from a dose Ng error that Vaccine was reported to be 90% effective when volunteers received a half dose and then a full dose, which was the mistake and less effective with two full doses. The British government's ordered 100 million units of the vaccine, but some scientists are expressing concerns about gaps in the testing reporting. AstraZeneca plans to conduct a new global clinical trial, but says that shouldn't delay regulatory approval. At least not in Europe. I'm Jackie Quinn.

Astrazeneca Oxford University UK British Government Europe Jackie Quinn
UK asks regulator to assess AZ-Oxford vaccine amid questions

AP News Radio

00:55 sec | 5 d ago

UK asks regulator to assess AZ-Oxford vaccine amid questions

"The British government's asking a health care regulatory agency to assess some issues that have arisen with testing for AstraZeneca's vaccine candidate the health secretary for the U. K. is asking regulators to determine if the potential covert vaccine developed by AstraZeneca and Oxford university should be authorized for use because the highest success rates in their findings resulted from a dosing error the vaccine was reported to be ninety percent effective when volunteers received a half dose and then a full dose which was the mistake and less effective with two full doses the British government ordered a hundred million units of the vaccine but some scientists are expressing concerns about gaps in the testing reporting AstraZeneca plans to conduct a new global clinical trial but says that shouldn't delay regulatory approval at least not in Europe I'm Jackie Quinn

Astrazeneca British Government Oxford University Europe Jackie Quinn
AstraZeneca probes 'mistake' behind 90% COVID-19 vaccine efficacy

AP 24 Hour News

00:13 sec | 5 d ago

AstraZeneca probes 'mistake' behind 90% COVID-19 vaccine efficacy

"Texas congresswoman Sheila Jackson. Lee is urging people to remain cautious. Despite anticipation of a vaccine soon. You will not get your vaccine toe way into 2021. You've got to continue to wear masks Continue socially distance. There are new questions about AstraZeneca's covert vaccine developed with Oxford University. Its effectiveness was reported with an error inducing now British regulators are seeking review of that data in Nevada officials say the virus is so bad someone dies every two hours in the state from covert 19. The coroner in Reno says she fears running out of room to store the dead.

Sheila Jackson LEE Astrazeneca Texas Oxford University Nevada Reno
AstraZeneca manufacturing error raises questions about vaccine study results

WTOP 24 Hour News

00:29 sec | 5 d ago

AstraZeneca manufacturing error raises questions about vaccine study results

"And Oxford University have acknowledged a manufacturing error. That's raising questions about the preliminary results of their experimental Corona virus vaccine. A statement describing the error came days after the company in the university described the shots is highly effective and made no mention of why some study participants did not get as much vaccine in the first of two shots is expected. In a surprise, the group of volunteers that got a lower dose seem to do much better and be much better protected than the volunteers who got too full doses.

Oxford University
AstraZeneca manufacturing error clouds vaccine study results

John Landecker

00:39 sec | 5 d ago

AstraZeneca manufacturing error clouds vaccine study results

"AstraZeneca is likely to run a new global trial to assess the efficacy of its covert 19 vaccine using a lower dosage. That's according to a quote from the chief executive today amid questions over the results from its recent study. Instead of adding the trial to an ongoing US process, AstraZeneca may launch of fresh study to evaluate the lower dosage of its vaccine that performed better than a full dosage. That's according to Pascal Story, Oh, the chief executive of AstraZeneca. Several scientists have raised doubts about the robustness of results released on Monday, which showed the experimental vaccine was 90% effective in a subgroup of trial participants, who by error initially received a half dose, followed by a full dose

Astrazeneca Pascal Story United States
"astrazeneca" Discussed on Daily Coronavirus Update

Daily Coronavirus Update

08:15 min | Last week

"astrazeneca" Discussed on Daily Coronavirus Update

"Podcast go ask galley. I'm talking to experts on how to grow a teenager. In a pandemic will be tackling such subjects as the sexualization of girls in the internet anxiety and kobe and what is higher education. Look like now listen. I was not around during the spanish flu but growing teenager seems to have gotten a lot harder. Listen to go. Ask allie on the iheartradio app apple podcasts. Or wherever you get your podcasts. It's tuesday november. Twenty four th. I'm oscar ramirez from the daily podcast in los angeles. And this is reopening america once again more good news on the vaccine fronts. Astra zeneca and oxford university has released some early. Data's saying they're vaccine candidate on average is seventy percent effective against krona vars. In some cases depending on the dosing it can be to ninety percent effective. This vaccine candidate is also cheaper to make and can be stored at normal refrigeration temperatures adam feuerstein reporter at stat news joins us for the latest vaccine results. Thanks for joining us. Adam here for the past few weeks we've had some great news on the vaccine front regarding covid nineteen and again this past monday. We got some more stuff. The vaccine candidate from astra zeneca and the university of oxford said that their candidate reduces the risk of symptomatic cove in nineteen by an average of seventy point four percent. They said it goes up to ninety percent. And we'll get into that in a minute because there's an interesting thing surrounding that. But what are we hearing about this vaccine candidate. I think you're right. It seems like every monday morning league. We've been getting backsied news which has been nice right. I mean we're all getting ready to start the week and we get a little dose of good news so right so like you said. This vaccine is being developed by astrazeneca and university of oxford over the uk. And so this analysis is actually. It's actually an interim analysis. An early look at two. Different studies conducted one in brazil. One in the uk was about eleven thousand participants and yeah on average. The efficacy here was seventy point four percent. So let's get into that because you did mention. There was a two different arms of this study one in the uk one in brazil and they were using different dosing methods. I think in the uk they were doing a half dose. I then a full dose and in brazil they were doing to full doses. Each time separated by about a month but they got different results on that right and it is a little confusing. I was trying to write the story about the data this morning very early this morning. I i was a little bit confused by it. But your so you're essentially correct right. They have different dosing regimens here. When the participants got two full doses of the vaccine spread out one month apart the efficacy was sixty two percent so a little bit lower than the average when patients receive a half dose initially and then received a full does the advocacy was ninety percent. So the question is that was essentially. Raiders is why would a starting with a half a dose and then going to hold those. Why would those results look better than when you got two full doses and the answer to that question questions. Not entirely clear yet. And it's even more confusing what we learn later today that actually this sort of half those old those regimen that they're using was sort of a mistake it came out of some dosing errors in the uk and when they discovered this this months ago when they discovered this in the clinical trial they just continued with it. And so it's a little bit confusing. And i think these are some of the things some of the questions that still need to be answered like to just sort of better accurately understand what the efficacy of this vaccine actually is. Wow what a lucky break if that ends up being like the dosing regimen that you need some experts guys like dr fauci said that maybe that half those kind of primes the body a bit better to receive the full dose and things like that so you know it kind of makes sense in that sense of it. In the united states we do have a trial going on. That one was put on pause for a little while. But i think they're gonna make some changes to try to explore that half those full dose regimen here. Actually i think is running a large study in the united states with the same vaccine. That was the study that had been halted for a little while. Because of a side effect that popped up in a single participant they had to halt it and they had to get clearance to restart. That's restarted so it. Looks like they may try to alter amend the study designed to kind of look at this half those full dose regimen to see what they can get out of that here in the. Us there are a lot of other pluses that go with this vaccine candidate as well though. It's a lot easier to store. It's cheaper to make so a lot of people are saying this could be really good for lower to middle income countries. But there's this kind of thing why would. Why would we give people vaccine. That's only seventy five percent effective versus one. That's ninety five percent effective like the pfizer and moderna vaccine candidates. But as you mentioned at the very beginning this interim data so this could change these numbers could change still like definitely change as we get more data. I mean we're looking at very many cases here that the basis analysis on so they could definitely change as they accrue more cases in the study. And you know look it's difficult to compare vaccines against each other. Even though everybody wants to do it right like you mentioned the moderna vaccine ninety five percent. Efficacy the pfizer bio intact vaccine ninety five percent the so on the phrase simplistic comparison. You look at those say well. Those are so much better than what we're seeing out of the actors. I think but again there are different types of seeing. They're made differently. As you mentioned there advantages the astrazeneca vaccine in terms of storage and they can be refrigerated. It's very easily shift and store doesn't a standard refrigerator. so that's gonna be beneficial for places where you you can't do the deep res kind of storage that is required for the Vaccine the murder vaccine. It's also going to be a lot cheaper so there's gonna be hard difficult choices that have to be made but these axioms. Because i don't think that you can expect all the vaccine to have exactly the same efficacy more safety. So you know a lot of people in the world you need to get vaccinated There's gonna be some decisions that will have to be made in that regard definitely but like you said everybody wants to make those direct comparisons even though you know. You can't really do that this vaccine and the other two leading vaccines are made completely different. The other to use messenger aren a this uses an identical virus which also kind of a newer method to to traditional vaccines. But still i mean this is all very promising that these different types of vaccines are working. Maybe to put in perspective you know when the fda issued their guidelines for what they wanted to see out of co vaccine sort of the bottom end of the range was around fifty percent advocacy right. That's kind of the minimum that they wanted to see so here. You have one that we don't really know where they actually gonna shake out sixty seventy eighty percent. I mean it's still well within the range of an approvable vaccine. Maybe it'll be ninety. We don't know yet. But i think the thing you can take away from this is is. This is witnesses third vaccine candidate and it looks encouraging. And you know. I think that's what we all want to see as we try to emerge from adam feuerstein reporter at stat news. Thank you very much for joining us. Thank you i'm oscar. This has been reopening america. Don't forget that for today's big news stories. You can check me out on the daily podcast every monday through friday so follow us on iheartradio or wherever you get your podcast ever wondered why there two ways to spell donuts or why some people think you can find water underground just by wandering around with a stick. Believe it or not. This is stuff you should know. You know the podcast. With over a billion listens. It's now for your eyes so you can read it stuff. You should know an incomplete compendium of mostly interesting. Things covers everything from the origin of the murphy bed to why people get lost preorder. It's stuff you should know. Dot com or wherever books are sold..

uk adam feuerstein united states university of oxford astra zeneca reporter flu brazil oscar ramirez los angeles iheartradio allie kobe america Raiders oxford university dr fauci murphy
"astrazeneca" Discussed on The Daily Dive

The Daily Dive

07:30 min | Last week

"astrazeneca" Discussed on The Daily Dive

"On the vaccine front astrazeneca. Oxford university has released some early. Data's saying they're vaccine candidate on average is seventy percent effective against grown buyers. In some cases depending on the dosing can be up to ninety percent effective. This scene candidate is also cheaper to make and can be stored normal refrigeration temperatures at employers steam reporter at stat news joins us for the latest vaccine result. Next some doctors and nurses are calling it quits over. The pandemic medical professionals are closing their practices or retiring early because of financial stress. Also the mental exhaustion of trying to stay safe. Corona virus continues to spread unchecked in the country reed abelson health reporter at the new york. Times joined us for why some doctors closing shop finally president trump's legal team has been a mess in the outcome of the election with no real evidence of widespread fraught legal team the steps to sydney powell. One of the lawyers who had appeared with rudy giuliani and push some of the most outlandish conspiracy theories about the election including that some republican governors were part of the plot bill national correspondent at the washington. Post joined us for why. They gave powell the boot. It's news without the noise. Let's dive in intriguingly in the results. The headline is seventy percent protection. And we do have a subgroup. You've got a half day. Says the first days and then a full day says the second is where we sold ninety percent protection joining us now. is adam feuerstein reporter at stat news. Thanks for joining us atom. Couldn't be here for the past few weeks. We've had some great news on the vaccine front regarding covid nineteen and again this past monday. We got some more stuff. The vaccine candidate from astrazeneca and the university of oxford said that their candidate reduces the risk of symptomatic cove in nineteen by an average of seventy point four percent. They said it goes up to ninety percent. And we'll get into that in a minute because an interesting thing surrounding that. But what are we hearing about this vaccine candidate. I think you're right. It seems like every monday morning lately. We've been getting backsied news which has been nice right. I mean we're all getting ready started the weekend. We get a little good news right so like you said. This vaccine is being developed by astrazeneca and university of oxford over the uk. And so this analysis is actually. It's actually an interim analysis. An early look at two different studies that they conducted wanted rehill. One in the uk was about eleven thousand participants and yeah on average. The efficacy here was seventy point four percent. So let's get into that because you did mention. There was a two different arms of this study one in the uk one in brazil and they were using different dosing methods. I think in the uk they were doing a half dose. I then a full dose and in brazil they were doing to full doses. Each time separated by about a month but they got different results on that essentially correct right they have different dosing regimens here. When the participants got two full doses of the vaccine spread out one month apart the efficacy was sixty two percent so a little bit lower than the average when patients receive a half those initially and then received a full does the advocacy was ninety percent. So the question is that was interesting. This is why would a starting with a half a dose and then go into a whole those. Why would those results look better than when you got two full doses and the answer to that question is not entirely clear yet and it's even more confusing. We learn later the day that actually this sort of half does hold those regimen. They're using was sort of a mistake. It came out of some dosing errors in the uk and when they discovered this this months ago when they discovered this in the clinical trial they just continued with it. and so it's a little bit confusing. And i think these are the some of the things some of the questions that still need to be answered like to just of better accurately understand why the efficacy of this vaccine actually is in the united states. We do have a trial going on. That one was put on pause for a little while. But i think they're going to make some changes to try to explore that half does full dose regimen here. Actually i think is running. A large study in the united states was the same vaccine. That was the study that had been halted for a little while. Because of a side effect that popped up in a single participant. They had halted. And they had to get clearance. This restart that's restarted so it looks like they may try to alter the study designed to kind of look at this half those full dose regimen to see what they can get out of that here in the. Us there are a lot of other pluses that go with this vaccine candidate as well though. It's a lot easier to store. It's cheaper to make a lot of people are saying this could be really good for lower to middle income countries. But there's this kind of thing why would. Why would we give people vaccine. It's only seventy percent effective versus one. That's ninety five percent effective like the moderna vaccine candidates. But as you mentioned the very beginning this is interim data this could these numbers could change still right and he's never seen definitely change as we get more. I mean we're looking at very many cases here that the basically allows on so the data could definitely change as they accrue more cases in the study. And you know look i. It's difficult to compare vaccines against each other. Even though everybody wants to do it right like you mentioned the moderna vaccine you know. Ninety five percent efficacy. The pfizer biontech vaccine. Ninety five percent could be so on the phrase simplistic comparison. You look and say well. Those are so much better than what we're seeing out of the actors. I think i've actually but again there's different types of vaccine. They're made differently. As you mentioned there are advantages the vaccine in terms of storage and they could be verge rated. It's very easily shift and store doesn't a standard refrigerator so that's gonna be beneficial for places where you know you can't do. E pres kind of storage that is required for the pfizer vaccine. The murder vaccine. It's also going to be a lot cheaper so there's gonna be hard difficult choices that have to be made but these axioms 'cause i don't think you can expect all the vaccines to have exactly the same efficacy war safety so you know there's a lot of people were all too need to get vaccinated. There's gonna be some decisions that will have to be made in that regard definitely but like you said everybody wants to make those direct comparisons even though you know you can't do that this vaccine and the other two leading vaccines are made completely different. The other to use messenger aren a this uses an a denno virus which is also kind of a newer method to to traditional vaccines. But still i mean this is all very promising that these different types of vaccines are working. Maybe to put in perspective when the fda issued their guidelines for what they wanted to see out of a covid vaccine sort of the bottom end of the range was around. Fifty percent epochsc right. That's kind of the minimum that they wanted to see so here. You have one. And we don't really know where they african gonna shake out is sixty seventy eighty percent. I mean it's still well within the range of an approvable vaccine. Maybe it'll be ninety. We don't know yet. But i mean i think the thing you can take away from this is is this is the third vaccine candidate and it looks encouraging. And you know. I think that's what we all want to see as we try to emerge from this pandemic adam feuerstein.

uk Oxford university reporter adam feuerstein united states sydney powell new york president rudy giuliani brazil trump washington murder
"astrazeneca" Discussed on Squawk Pod

Squawk Pod

07:47 min | Last week

"astrazeneca" Discussed on Squawk Pod

"They get the us data. This to the list of dumb questions. I'm to ask this morning. But when we say seventy percent efficacy or sixty two percent efficacy or ninety percent efficacy that means it works in ninety percent of the population that has taken it. it doesn't work in ten percent or it doesn't work not that you have ninety percent immunity. You either have immunity or you don't have immunity right. Well there actually a couple of different ways of looking at that and so the way you get that figure is you have a total number of cases in the trial and then the ninety percent is the difference between the number in the placebo group in the number in the vaccine group But there are some vaccines like the flu vaccine. That might not prevent you from getting the disease completely but if you do get the disease much. Milder and so vaccine can have all different forms of efficacy and it's not always binary necessarily but the efficacy numbers. We're talking about today. We don't really know other than it kind of breaks down on the population that much less likely to get it. You know ninety percent less likely to get it because it's been effective in that portion of the people right now right yes exactly and i need to dig through but if it's the same as the other vaccines than it would be The likelihood of you getting a symptomatic cases and then we just don't know yet about the likelihood of getting infected but not having symptoms okay mic. So guys we're going to switch directions right now in bringing rudolph who is the head of astrazeneca's us business and executive vice president biopharmaceuticals to talk about astrazeneca oxford vaccine results. This morning dr robert. Thank you for being with us and help us understand these data. I mean on the one hand you've got ninety percent efficacy in one dosing regimen on the other. Sixty two percent efficacy. Can you organize it. So that the ninety percent regimen will be the one that gets distributed out to the world. So thank you so much for having me and we're very excited about the data. We released this morning first of all. The study is showing when you use those in high-dose that the efficiency is indeed ninety percents which is Which is incredibly strong equally. Even if he used high. Those high dose. It's still a very strong response of over sixty sixty two percent i We believe and we think that regulators will focus on this a half those Full dose regimen. But of course that's in the handle of the regulators but overall it's a very strong settle of data equally. I think it's very important to remember that. All vaccinated participants didn't develop the disease so no hospitalization or any severe disease characteristics caused by covid nineteen So all in all. I think a very strong set of of data as we all know. The world needs effective Vaccines and santa. Oxford are very pleased. There's one point. I really wanted to ask you about because i was mistaken about it actually earlier as i was going through the data so quickly you see here that there is an early indication that the vaccine could reduce virus transmission from an reduction in as symptomatic infections. Tell us about that. finding i mean. Are you actually finding that. This vaccine could produce. What's known as sterilizing immunity really keeping people from getting infected at all with the virus. Yeah that's that's an excellent question. Many questions One question clearly duration of protection and the other question is is the question. You're asking about the transmission. We've only seen the data over the weekend so it's very early days but but we have seen so far is is a believe that we can also reduce the transmission of vaccinated people including asian domestic Participants so once again. It's still very early days. But what we have seen and we will see more in the in the course of this week when the investigators the can nickel trial is will ride the story in a in a in a high profile journal journal. Pleased to see what we have seen so far think. It's a little bit too early in order to be definitely the that these dr dobson listening is great news. Congratulations it looks like we're going to have a couple of hopefully working vaccine's very soon take us through the next step. I'm sure you and your team are i. Hopefully working with governments state local officials frank global coordinated response to getting it out take us through the thought process. First responders get it. I hopefully then teachers. We have to get the kids back into school. Irreparable damage is being done to millions of families around the world. Obviously then the most vulnerable outside of that. Who will make the decision about how these vaccines are distributed. Because you know rich people are gonna be kind of like. Hey how do i get on the list. How do we make sure there's an equitable and ethical distribution of these vaccines. Yeah thank you so much for for this a very good question so first of all let me go back to the first step we need to make and the first step we need to make clearly is to go out to the regulator so in the course of this week we will show the data to the uk regulated european regulator and also to the fda in the united states. So that's a very important. I proof points. The second part is of course we need to do the filing of the dossier and then the deregulates and needs to have an independent assessment of all the data. We We are showing them that it's coming back to your point about who's going to get the sex scene. Astrazeneca made a huge commitment to provide the vaccine at no profits and in that way so we have supply chains in the united states in the uk and europe and also in the developing countries in the world. so that's a very important part of our strategy to make vaccine available so all the people around the world and that this is not reserved only to rich countries or the rich people number. I know you've struck a number of manufacturing partnerships in order to have monumental supply of of this vaccine. I want to ask you just about these data again just to really try to understand it better. You mentioned one hypothesis for why this dosing regimen produce. Such better efficacy another hypothesis. I've heard about this morning is that there might have been different. Factoring processes for the the different doses. You used and so there could have been different quality in terms of the engine that you were showing people's immune systems with the vaccine and perhaps led to this better efficacy with one regimen versus the other. So i wonder if you could tell me about whether that's likely if there were different processes as you were moving so fast obviously and then also how the situation looks in the united states with the fda given that you were on pause here for about seven weeks and the us data could come so much later so first of all yes there were different processes but at this stage. We don't have any evidence in order to to say that that's causing the the different so we stick to the day. Of course we will do everything in order to get more clarity about the processes. We have seen in in in the last few months once again. The scientists are quite They have seen it in the postles in laboratory trials so we need to be patient in order to the regency the full data sets a and of course when they send us a favorable we will clearly published in international journals regarding your second question about the fda We are running very large Us specific study as we speak before already included more than ten thousand volunteers in in those studies but equally. Of course we will engage the fda later in the week to show them the data and depending on that guidance we will define the next steps of.

united states flu vaccine astrazeneca Milder astrazeneca oxford executive vice president bioph dr robert uk santa dr dobson rudolph frank global europe
"astrazeneca" Discussed on Squawk Pod

Squawk Pod

03:07 min | Last week

"astrazeneca" Discussed on Squawk Pod

"We have such good news and among the top story is late. Stage trials showing the astrazeneca oxford covid vaccine can be up to ninety percent effective. Make terrell joining us now with the full details. Beg good morning good to see you. Good morning guys so another vaccine. Monday here astrazeneca reporting results from its pooled trials from multiple countries <hes>. Showing that <hes>. When you look at the data together you are more than ninety percent efficacy. It's a bit of a confusing result. Though because one dosing regimen showed that very high efficacy another showed sixty two percent of the so together. It's about seventy point four percent effective when you combine those two dosing regimens now. The difference was where you've got that ninety percent number that's when they gave a half does on the first dose and a full one on the second one together they are saying these are very positive data and they do plan to start submissions where they can around the world now they also say there was a large safety database for more than twenty four thousand volunteers in the uk brazil and south africa <hes>. With follow up since april another thing. That differentiates this vaccine is it can be stored at fridge temperature. Thirty six to forty six degrees fahrenheit and distributed using existing logistics the tremendous manufacturing capacity. They've made a lot of different partnerships <hes>. So this vaccine could really add to supply. We are still digging through those data and understanding. Exactly how the different dosing regimens led to such different advocacy results. We'll talk with experts and bring that to you this morning. But the headline one of these dosing regimens more than ninety percent effective. Seventy percent when you put both of them together guys. Back over to you meg. I have so many questions for you. And i realize it's early and you're just going through all of this to you may not have the answers to any of this yet. But look ninety percent efficacy. That's really great to it doesn't compare it doesn't match up quite as well as we've seen with both pfizer and with moderna with the ninety five percents efficacy but ninety percent. That's really good. Sixty two not so great. What do you do. You have any idea if it had anything to do with where it took place <hes>. Just geographically in terms of these phase phase. Three trial results. If it was different in south africa it was different in brazil. It was different in the uk or if it was age groups that were different. That also played into that as well or was it simply the level of dosing. When i've seen so far in the data and these i really woke up to they did release them overnight but we did not find out about them on embargoing advance which we sometimes do and gives us time to really dig through them <hes>. So from the headlines. That i've had a chance to really dig into it really does seem like a dosing difference for some reason given that half those on the first dose and then a full dose on the second lead to that much higher efficacy <hes>. And so something. I really want to understand the name. I've already been reaching out to vaccine experts this morning to try to get a sense for. Does that line up with what would make sense about how a vaccine works. And is there good explanation for that so we can really understand. Why difference. certainly. There's a huge difference between sixty two and ninety between ninety and ninety five. That's pretty good.

"astrazeneca" Discussed on KCBS All News

KCBS All News

01:37 min | Last week

"astrazeneca" Discussed on KCBS All News

"And AstraZeneca are all going to be to dose vaccines and that's difficult cold chain required to transport them that minus 94 F that matters. Washington Governor Jay Inslee has announced $135 million in assistance for businesses and workers hurt by new coronavirus restrictions. He has imposed Cairo TVs Essex Porter got reaction in Olympia with new code restrictions in effect, all the dining is outside now with, well 80 brewhouse at Olympia owner Chris Kanoute's in could see what was coming. Can't Fault the science for saying this seems like a place where this thing is going to spread because it's just a bunch of people hanging out without masks. Like many small business people affected by covert 19 restrictions. He's looking to governor Inslee for help. So Insley added new money to covert 19 relief. President elect Joe Biden could name top leaders for his Cabinet next week. He held his first in person meeting since winning the election with House Speaker Nancy Pelosi and Senate Democratic leader Chuck Schumer. Yesterday. CBS is Ed O'Keefe on his transition. President elect Biden met with Democratic congressional leaders will partner with next year. But there is growing frustration inside his transition team is the Trump administration continues to block access to federal agencies and resource is, I just think it's totally responsible. Now. Top House Democrats are demanding the head of the general Services Administration. Emily Murphy brief them by Monday on why she hasn't declared Mr Biden the winner and allow the transition to begin. Police are looking for a man who shot an injured eight people at a mall near Milwaukee. Witnesses say it was chaotic when the shooting started. Everybody started screaming. I just ran Expresses.

Joe Biden Governor Jay Inslee President AstraZeneca Porter Olympia Emily Murphy Chuck Schumer House Speaker Nancy Pelosi Washington governor Inslee Ed O'Keefe general Services Administratio Insley CBS Chris Kanoute Senate Milwaukee Cairo Cabinet
"astrazeneca" Discussed on The Highwire with Del Bigtree

The Highwire with Del Bigtree

02:03 min | 2 months ago

"astrazeneca" Discussed on The Highwire with Del Bigtree

"Child's autism We do have millions of parents that complain that both the vaccine or the de tap act seen that immediately after they regressed into autism losing speech, lose the ability to walk and talk so. Arthur were not looking at every possible issue were proving the null hypothesis they like to joke and I don't think you should ever lie I mean I was raised that you never lie. You always tell the truth and pull up and say, Hey, we can never really say that vaccines cause autism but you better get used to eating it. I mean saying it because people will use that against you. These people are the ones that are going to be voting for this future back there writing your informed consent literature and language, and they're telling you when they're behind closed doors. Screw the truth do whatever you have to to win. Is that what you thought when you wrote this, you know informed consent sheet that got someone killed, and by the way that case was settled out of court they didn't lose. We don't know how much they won. Well the informed Consent Action Network is a nonprofit I started because of people like that Paul op in Arthur Caplan who clearly are intelligent people but seem to laugh and Giggle at the idea of doing a proper study and no, it's not impossible. It's not impossible to do a study that would find out whether he vaccine or even coca-cola for that matter. You could easily take databases at the CDC find out who drinks Coca Cola and then see if there's a rise. In. The rate of autism and back, that's how we do many of the studies we do on every drug. We take this planet though I'm no leader of Naiad or head back seen maker I do understand how studies work, and we have been able to do studies like this since the dawn of science if you like that clip and be sure to check out our live broadcast, the high wire, every Thursday morning at eleven am Pacific Time you can watch it on facebook. I tunes end twitter. We'll see you there..

Arthur Caplan Coca Cola Consent Action Network facebook CDC Paul op
"astrazeneca" Discussed on The Highwire with Del Bigtree

The Highwire with Del Bigtree

06:42 min | 2 months ago

"astrazeneca" Discussed on The Highwire with Del Bigtree

"Bass subsided kind responsible is what happened to Jessica elsever, which was a massively cited responsible sex I mean now we have you know monoclonal antibodies directed against Interleukin six Lantos Elizabeth then. Sort of Jesse Jessica housing unfortunately died but you always wonder when you're giving that many our particles that you could you could do. A lot in this just in that moment, this interview First of all, he keeps saying replication defective mini. It doesn't replicate itself like other viruses therefore, they have to deliver one viral particle per cell they want to infect can you imagine? So let me get this straight I can take my risk with what appears to be a common cold for more than eighty or ninety percent of US only a quarter of one percent at the most with the most bloated numbers we've ever seen risk death from the virus itself or I can get this Frankenstein vaccine and one hundred billion viral particles injected right into me to start mutating one cell at a time what could possibly go wrong. What can go wrong is what he's saying what could go wrong? He admits it aside the kind storm, a massive inflammatory event that could kill you. Oh, and by the way it was one of these adenoviruses approaches to gene therapy that killed this this gentleman, Jesse, Gelsinger. Well, this took us on a deeper dive and I think in some ways, what's ironic is pull off at maybe accidentally through one of his own under the bus and I'm GonNa get into that. All these people are now starting to spew their incredible knowledge while unknowingly rule boulders that are crossing. Each other along the way and I'm going to try to help do that a little bit today because this is a horrific story and we knew nothing about it until we saw this interview with Dhaka poll opposite look at this article. So this is the death of Jesse Gelsinger twenty years later, Jeff by all accounts Jesse Gelsinger was a sweet sharp witted if not particularly ambitious kid who loved motorcycles professional wrestling in nineteen, ninety nine he was living in Tucson Arizona with his parents and siblings attending high school and working part time as a supermarket clerk he got. He became more independent and like many teams a touch rebellious in his case that lead to life threatening health problems. He had a by the way of my the real issue that he had really specific to certain diets. When he got up those diets, he could get very very sick. I. Think part of what they're referring to. Jesse, was the eighteenth person received a modified virus previous patients in the trial had experienced flu like symptoms but he had a much worse reaction within a day. He became disoriented shown signs of Jaundice. He had an intensive slamming Tori responses about the dangerous blood clotting disorder followed by kidney liver lung failure. Remember, we were seeing this the my studies and the monkey studies was Kobe nineteen four days after receiving the shot Jesse was declared brain dead and taken off life support. the team of doctors and nurses caring for him was stunned by his rapid decline and death. This is a horrible horrible story. But what's interesting is this is the technology being used by multiple vaccine makers right now, that are part of this works speed program and it gets more interesting in this is the part that. Really starts to out many of these players that are involved in this particular this. Lawsuit filed in I known gene therapy death this web. September twentieth two thousand almost exactly a year after eighteen year old Jesse Gelsinger is death during a gene therapy experiment Gilson singers family has filed a lawsuit against the University of Pennsylvania where the treatment took place Joel. Singer. Was the first person known to have died from a gene therapy treatment also named in the fifteen page complaint filed Monday in Philadelphia or James Wilson MD the lead researcher in the case and you heard this name earlier today Arthur, Caplan PhD director of the Bio Ethics Program at Penn what is it bio ethicist have to do with this case we'll it goes on. To. Explain that the lawsuit asked for unspecified damages because of what it describes as carelessness and gross negligence on the part of the doctors after an investigation, the gene therapy program at Penn, the FDA shut down the program studying numerous safety violations including a failure to report that other patients had experienced liver problems from the treatment. Another unusual aspect here we go of the case is the involvement of high profile at this happen as a defendant this suit says, he helped to write the informed consent document for the treatment of form that is supposed to inform participants about therapies, potential risks and benefits, and consulted with Wilson about other ethical aspects of the experiment. So here is the question we've been having about the Kobe nine hundred. Trials, and when we talk about challenge trials in humans, what is this informed consent document going to tell them or the people in these trials being told that? Jesse Gelsinger died from this treatment. We're about to try anew the Kobe nineteen back seen I highly doubt it did they tell you that the animals died and had cited kind storms as Paul describe it in the animal trials before we started rushing this vaccines in the human beings at the center of this is so called ethicists is being sued. Because he wrote the informed consent part of this trial and the parents are saying we were warned of the dangers. You didn't tell us the truth really Arthur Caplan not telling the truth that sounds familiar. It reminds me of a video we once played where you got it both Paul up and Arthur Caplan or sitting together is an Oldie but a goodie take a look at this. You can never really say more doesn't cause autism. But frankly when you get in front of the media, you better get used to say it because otherwise people hear door being left open when a door shouldn't be left on. He can't prove the Coca Cola. Either but we just don't happen to be having that particular fight yet. So you know you're sort of something you're in a debate. Going to tweet that. and. Unfair. Debate. Debate you have to fight unfair. You can't use facts. You can't use the truth and though as far as I know there's been no complaints by the millions of parents around the world that Coca Cola is what caused their.

Jesse Gelsinger Jesse Arthur Caplan Jesse Jessica Kobe Coca Cola Penn Gelsinger James Wilson MD Jessica elsever Paul Lantos Elizabeth flu Dhaka Tucson Arizona Caplan PhD director Tori Philadelphia
"astrazeneca" Discussed on The Highwire with Del Bigtree

The Highwire with Del Bigtree

08:24 min | 2 months ago

"astrazeneca" Discussed on The Highwire with Del Bigtree

"The two cases of serious illness in his trial. The first participant received one dose of the vaccine before developing inflammation of the spinal cord known as transverse my elitest according to a participant information sheet for AstraZeneca's vaccine from July. The condition can cause weakness in the arms and legs paralysis pain and bowel and bladder problems. A company spokeswoman told The Times last week that the volunteer was later determined to have a previously undiagnosed case of Multiple Sclerosis unrelated to the vaccine trial resumed shortly thereafter think about this folks we told that there was just one case of transverse. The other was multiple sclerosis. Now, we're finding out the diagnose the first one as transverse. My elitest to you can see where the confusion is both happening the spinal cord and back transfers. My elitest can lead or can show the signs of multiple sclerosis. They can come at the same time together or recognize the other but do you see how problematic this is this article goes on company. If. There are two cases. Then this starts to look like a dangerous patterns said, Mark. Slipped vaccine expert at Oregon Healthy Sir does in Science University a third case of neurological disease POPs up in the vaccine group. Then this backsied maybe done really is a really going to take a third case to isn't enough. We don't have to like permanently or destroyed the lives. Of people maybe for the transfer is my lightest case maybe she'll recover and it won't be permanent. But who knows what happens down the road? Let me correct that statement but it goes on Dr Mark Goldberger and infectious disease expert. The Global Antibiotic Research and Development Parsh- partnership in former FDA official said he found the rapid restarting trials abroad to be alien this summer disturbing. You think especially given the lack of details around the patient's symptoms and the. Connections to the vaccine. This is it real pro vaccine people really terrified of what's happening here and here comes one of the leading pro vaccine people communication around it has been horrible and unacceptable said Dr Peter J Hotel, has a biologist with Baylor College of Medicine in Houston. This is not how the American people should be hearing about this. Of course, Dr Houghton has been working on his own back seen Dr Houghton has also there is he's been working on the co-pay nineteen back seen he has already had trials of the corona virus vaccine previous failed. Let me point that out. Dr. Ho's Tez also criticized. Statements released by government officials including UK regulators who he said, they'll to supply irrational erosion rationed. Now, resuming their trials tell us why you came to that decision. He said, I'd love to know the same thing why are you re starting to trials after now two cases of originally diagnosed transverse by elitest. It goes on Dr Paul off look at these players. This is amazing. Isn't it? I told you Kobe nineteen. This maxine is going to be the gift that keeps on giving to those of us who have been trying to wake up the world to backseat injury. These geniuses are finally helping us out Dr Paul off at a professor at the University of Pennsylvania and a member of the FDA's Committee on backseats. Pay Close attention that folks by the way he is on the Advisory Committee. Paul up and it's going to be involved in approving this vaccine whether it's emergency use or however is delivered to us this Guy Paul up it is going to be one of the deciding votes and let me let you know Paul we are watching you hold you personally responsible if you release a vaccine causes transverse. In. Anybody at the you know there's already potentially two cases in this one trial and remember that one trial had as we pointed out earlier, all the monkeys got sick after the backs he wanted his trial every been moved out of the monkey studies is absolutely shocking to go on and find that you've now injured two people and looking to get more injured is incredible. Let me get back to this point Dr Paul off a professor. At. The University of Pennsylvania and a member of the FBI's Advisory Committee on Vaccines said that it's unclear how the company or the UK government determine that the second case was not related to the vaccine about the first Paul I. First, the first case how is it clear that that was not caused by the vaccine I'd like to know that too he other experts noted that transverse mileit is is rare diagnosed and only about one in two hundred and thirty, six, thousand Americans a year to trial in. Britain. Only about eight thousand volunteers as spokes person for the Oxford researchers said last month eight thousand. And I my understanding is there's a placebo group in there and I'm GonNa assume that then half of that group is getting the vaccine. So we saying that One in four thousand or two cases of transportation. My lightest one in two thousand compared to one in two, hundred and Was it sixty, thousand, thirty, thousand? This is incredible folks and it's really amazing. I was asking questions about MS and now we're finding out no that case they believed to be transferred to Really really shocking. But. Here's the last line the vaccine being developed by Astra Zeneca which born to partnership with Oxford. University. Scientists uses the virus meant to carry corona virus genes into human cells and trigger an immune response that will protect people from the corona virus this. So called vector is a modified form of an Adenovirus that causes common colds in chimpanzees but considered safe for people several other companies. Including Johnson and Johnson and Ken Sinoe are pursuing similar adenoviruses based approaches although there are multiple types of adenoviruses and specific ingredients differ from vaccine toback seen essentially very quickly. They take this adenovirus that really only affects chimpanzees supposedly they use that like a little spaceship, they put a gene and spent to sort of make your cells, mutate themselves to fight the coronavirus and they send that little. Gene hiding aside that antibiotic Adenovirus into your body through the vaccine While we were researching this, we found a very interesting interview with Dr Paul Up at who is on this advisory. Committee at the FDA take a listen to what he says here this takes this even deeper into our conversation. So maybe is it possible that there weren't just to injuries in this vaccine trial this approach, the Adenovirus vector approach to delivering genes possibly known to be dangerous I. Think. So take this. He wonder always wonder when you're when you're giving a fever inducing agent, you know that you could either trigger exacerbate any truly be logical. So that's why I'm with replication defective viruses like the reputation back Simeon adenoviruses pink despite Zeneca where the reputation of that twenty six pursued by Johnson Johnson but replication about the add five which is being. pursued. By both the Russian and Chinese groups The. So the good news replication active, which means that the buyer scam you produce, it's open and caused him. The bad news has because it's replication defective. You really just get one virus per cell to May you get one cell per viral particle to make the protein you're interested in, which is the coronavirus spike wrote. So you get a lot of you're giving I think that recent Russia paper skin out this morning gave a hundred billion buyers particles the and and it's been around that between it's at least ten billion dollars particles I mean, maybe the The you know I feel burn because I'm at the University of Pennsylvania but replication defective adenovirus that that was given the Jesse Gallison you know was the first. Right. Ryan I was replication defective ad I forgot about that. Everyone knows it was gene therapy but not you're giving a little more specificity gets important. Yes and so so you worry that you could induce. Bass subsided kind responsible is what happened to Jessica elsever, which was a massively cited responsible sex I mean now we have you know monoclonal.

Dr Paul Multiple Sclerosis University of Pennsylvania Dr Mark Goldberger FDA Astra Zeneca Johnson Johnson Dr Houghton UK Oxford Dr Peter J Hotel professor Dr Paul Up Global Antibiotic Research and Advisory Committee Kobe Baylor College of Medicine Oregon Paul I. First
"astrazeneca" Discussed on The Highwire with Del Bigtree

The Highwire with Del Bigtree

06:35 min | 2 months ago

"astrazeneca" Discussed on The Highwire with Del Bigtree

"I want to get into the covid Nineteen Vaccine Donald trump sat down with Mark Levin this week and he had something very interesting to say. that. I WanNa talk about this. We have many companies doing it great companies Johnson Johnson Pfizer. MODERNA. We have many companies doing it and. Almost all of them having so far seemingly very good. Results they're in phase three trial that means a right at the end of the process. Really looking good and could be really early and so all of a sudden instead of saying, wow, this is great news. We're GONNA have. The vaccine early. This saying Oh, the vaccines coming out too soon, it's going to be unsafe. It's going to be all of these things. Has Nothing to do with the safety he's great. Companies are going to put themselves on the line they would have tremendous liability. Obviously president trump has got that wrong. You know I hate the term fact checker but I've got to be honest on this when he says that they would have tremendous liability. Obviously they're not these manufacturers you know Madonna and Pfizer and Johnson and Johnson aren't going to rush back scene out where they would have tremendous liability. You're right Mr President, your right. They wouldn't if they had liability which is why in the middle of Warp speed I would really appreciate it. If you would put liability back on this industry, how can we trust any product by companies that have paid out hundreds of billions of dollars for murdering innocent? People how they murdered them by lying about safety whether it was Johnson and Johnson with talcum powder or Johnson and Johnson and the sackler family with Oxycontin or Merck and viaducts, or I could go on and on and on. But those were drugs and we could sue MR president we cannot sue they are not liable and that as a serious problem and it the nine, thousand, nine, hundred, ninety, six wasn't bad enough. Let me bring your attention Mr President to the PREP ACT which I hope you're aware of, but this is it this even the supersedes the eighty-sixth public readiness and Emergency Preparedness Act the public reading this an emergency. Preparedness Act Prep authorizes the Secretary of Department of Health and Human Services to a declaration that provides immunity from liability. For claims of loss caused the rising out of relating to or resulting from administration or use of countermeasures to diseases, threats, and conditions determined by the secretary to constitute a president or credible risk of future public health emergency. It titles individuals involved in the development manufacturer testing distribution administration, and use of such countermeasures meaning vaccines folks a tax prep back. Declaration is specifically for the purpose of providing immunity from liability and is different from and not dependent on other emergency declarations. This is problematic. This is extremely problematic and Astra Zeneca was even bragging about this just a few weeks ago in many ways you know reported as having said, this is astros elegant to be exempt from. Backseat liability claims in most countries they went on to say, this is a unique situation where we as a company simply cannot take the risk. If in four years, the back scene is showing side Effects Rude Daba, a member of Astra. Senior executive team told Reuters what have been four years people start dropping like flies from immune enhancement that we thought. We'd overcome what if they have multiple sclerosis would they die like cancer like they did the polio vaccine when we asked Bentley Simian, retrovirus contaminating everybody, we can't be held liable for that and so Mr President while they're not liable, I would really like you to not use it as one of the arguments on why we should be happy about warp speed. But let's talk about Astrazeneca last week reported that they did have an injury it's not four years down the road is not four months down the road and just happened days into their own trials Zenica suspense leading kkob in Nineteen back seen trials after a participants illness. Of course, I'm talking about the transverse by elitest case that we just discovered. It was reported last week. But there is more information now coming out I want to get into that. It doesn't end there. Right? One of the things that I was curious about last week was the discussion about this transverse biologist case I even tweeted out get ready in about a week. They will tell you that this didn't happen. So you understand Francis my alliance this is a photo of it. You see that little lesion right there in the darker, the Dark Gray Strip in the spinal column that little lesion that's transverse by elitest it can be life threatening it can be paralyzing permanently oftentimes temporary, but it tends to be on set very quickly. It happens very quickly upon a reaction to a backseat. It also can happen by the way from natural virus, but we were told last week that transverse. This. was diagnosed in this, but it was the only case Oh by the way there was a multiple sclerosis case that we didn't tell you about about back in July just so you can see fairly similar on the right there. Again, you're seeing swelling in the spinal cord area that's multiple sclerosis. So you can see that these are very similar. Of course, multiple sclerosis can go on and have lesions in the brain and lead to many many problems for a lot of people. But I WANNA talk about New York. Times article came out. They got more in depth I'm GonNa read a bunch of this. In fact, I could have read the whole thing out loud again, just go type in I can right now into your comments or tweet US I mean text us I can't a three to two and you can get this whole article but let's read through it together. Shall We take this? Experts have been particularly concerned about Astrazeneca's vaccine trials which began in April in Britain because of the company's refusal to provide details about serious neurological illnesses in two participants both women who received experimental vaccine in Britain those cases spur the company to halt its trial twice the second time earlier this month, the company has released beauty details about.

president Johnson Johnson Johnson Pfizer Astra Zeneca Donald trump Mr President Secretary of Department of Hea polio vaccine Astra Pfizer vaccines Britain Mark Levin Reuters Merck Zenica astros Madonna New York
"astrazeneca" Discussed on AP News

AP News

11:46 min | 2 months ago

"astrazeneca" Discussed on AP News

"Oxford university says trials of a coronavirus vaccine that is developing it with pharmaceutical company AstraZeneca well the risks you days off to being pulled due to a reported side effect in a patient in the U. K. in a statement the university says in large trials such as this it's expected that some participants will become unwell and every case must be carefully evaluated to ensure careful assessment of safety it said the globally some 18000 people have received the vaccine as part of the trial and AstraZeneca spokesman said earlier this week that a woman had developed severe neurological symptoms that prompted the polls in testing there is shockingly London

Oxford university AstraZeneca London
"astrazeneca" Discussed on Bloomberg Radio New York

Bloomberg Radio New York

01:55 min | 4 months ago

"astrazeneca" Discussed on Bloomberg Radio New York

"AstraZeneca, the latest company in the race for a Cove in 19 vaccine, or Emery, Horton and Matt Miller spoke with the CEO of Astros and I could take a listen. We have vaccinated almost 10,000 volunteers in the UK And we are well. Now wait vaccinating fast 1000 volunteers, and we may even scared of that steady, making bigger and we also are on all the volunteers in South Africa, where we're going to run. The study was about 2200 volunteers. On. We're just about to stop in the US, So we are Southern in force way enough people. Skol. Good morning, Emory in London here, you said you don't want to make a profit. You don't plan on making a profit from the vaccine during the pandemic, But what about the pandemic is over. What do your pride pricing plans going to bay? Focus right now is actually to Delhi this vaccine. And do is that pandemic in the reason we wanted to do it that? No. We thought no. This is clearly an example of a disease that we have to tackle globally. We're all in it. Everybody has to be vaccinated in protective and therefore we wanted to bring the vaccine to as many people as possible around the world at a low cost hearme or interviews like this one on Bloomberg television streaming live on Bloomberg dot com and on the Bloomberg mobile APP or check your local cable listings. Feeling that seems have been expressed that we'd like to get an outcome. I certainly hope we can Corona viruses, certainly not over. It's still an enormous problem still affecting communities all across the country. Senate Majority Leader Mitch McConnell there. Is he leading or is he following down in Washington, D C.

Bloomberg Mitch McConnell Astros AstraZeneca South Africa Matt Miller CEO Senate US UK Emery Emory London Horton Washington
"astrazeneca" Discussed on 790 KABC

790 KABC

03:13 min | 6 months ago

"astrazeneca" Discussed on 790 KABC

"At this rally pharma giant AstraZeneca struck a deal with the European alliance to supply up to four hundred million doses of an experimental Colbert nineteen vaccine the alliance which was forged by Germany France Italy and the Netherlands to speed up production of a vaccine is set to take delivery of the vaccine being tested by the university of Oxford by the end of twenty twenty the agreement with AstraZeneca also aims to make the vaccine available to other European countries that wish to take part the cost is expected to be offset by funding from the government's I'm Marlys Majerus the Senate's top Democrat is concerned about recent upticks of the corona viruses need to understand why the spikes are happening and how to adapt our national response that's why Senate minority leader Chuck Schumer says top health officials need to come before Congress I'm requesting the doctor found she and Dr beers and other members of the administration's corona virus task force conducted briefing for democratic senators on the recent spikes and do it next week more cities and states across the country are reporting increasing rates of coronavirus cases every day since many of them have begun to end the corona virus related shutdowns Linda Kenyon Washington I'm in Kate's right talk radio seven ninety KABC news at twelve oh three I am Tom Looney LA is number one for a lot of things film TV and commercial production and homelessness our homeless population county wide as exploded it's grown by as many as ten thousand that makes the grand total about sixty six thousand people before taxes Torrance police should fall the identity of the woman who's been accused of physically and verbally assaulting Asians at Wilson park her name is Nina Hernandez I haven't found it yet they don't know what they're gonna do with their once a fighter there's been a coronavirus sergeant California but health department officials are saying that it may be because of the fact that more people are getting tested and not really because we're getting sloppy Chula Vista bigwigs have taken down their big Christopher Columbus statue they wanted to do it before protesters did it themselves seven ninety KABC sports Adam Abdul Jabbar the son of Laker Kareem Abdul Jabbar has been arrested for stabbing his neighbor allegedly KBC socal weather sunny today high the cervix seventy one in Culver city seventy two in Montecito heights seventy three at Sherman oaks I'm Tom loading that dialogue started here in the sixties the dialogue continues here now where LA comes to talk talk radio seven ninety KABC D. A. B. C. dependable traffic right now four oh five north bound the victory Boulevard offramp away from the north world five is closed because of a police investigation traveling farther up the four oh five north bound writer Roscoe Boulevard and extends over on the right hand side so the full five northbound yourself from Skirball center drive up to Roscoe Boulevard west one one the Ventura freeway jammed up from van Nuys Boulevard to parkway Calabasas that's dependable traffic hi.

AstraZeneca European alliance
"astrazeneca" Discussed on P&L With Pimm Fox and Lisa Abramowicz

P&L With Pimm Fox and Lisa Abramowicz

05:40 min | 6 months ago

"astrazeneca" Discussed on P&L With Pimm Fox and Lisa Abramowicz

"Because that's the way back in March I. was just you know? Nobody had any appetite for anything emerging market? Yeah, exactly. This is Bloomberg markets with Paul, Sweeney and Bunny Quinn on Bloomberg radio. Markets the man said so. Let's get to our next conversation now. With virologists from Harvard University Dr Peter Kinski actually extremely excited to speak with you. The author of the Great American drug deal new prescription for innovative and affordable medicines so Dr Kaczynski. Will it be the great American drug that provides us with our vaccinations, or will it be great Chinese drug? Thank you very much for having me on the show I should point out. I. I am a scientist by training. I did my of Raji training at Harvard but for my whole career than a by technology investors venture capitalist, so I. Look at this industry from the standpoint of an investor, evaluating a lot of different companies and I think that while China has been a larger player in drug development industry over the last ten fifteen years. I think that? The Kobe response globally has been someone nationalistic, and my guess is that China's going to conserve its vaccine doses for its own people and you know Europe is looking to lockdown doses, and so the US is going to be getting those from companies that its contract with. So Peter! You know some people talking about you know whoever gets at first, maybe just license it to everybody else for the common good. Is that a is that something you think could happen here, or is this something that maybe some of these companies are going to look to profit off of? You know if only at work that way, but you know the. Getting there I it's not like writing a book and being able to just hit publish, and then there's infinite downloads you know you can get there first, and then you have to actually scale up manufacturing, and so the first vaccines that are likely to prove out maybe later this fall They're still going to be constrained by the fact that you know companies. Companies are going to be scaling up manufacturing, and maybe getting to the point of tens of millions of doses if we get to a hundred million doses by the end of this year, collectively across a few vaccines that'll be amazing, but that's not enough to vaccinate you know even the the US let alone US Europe and all the other countries that are out there..

Dr Peter Kinski Bloomberg US Dr Kaczynski Harvard China Europe scientist Raji Bunny Quinn Kobe Paul Sweeney
"astrazeneca" Discussed on WJR 760

WJR 760

02:07 min | 6 months ago

"astrazeneca" Discussed on WJR 760

"News of progress by another coronavirus vaccine this being developed by AstraZeneca AstraZeneca says it will enter phase three testing of the vaccine it is developing in July and expects to have results in August AstraZeneca says progress has been made and AstraZeneca says that they believe they may have a vaccine for corona virus available by January they say that if this vaccine proved to be effective and they think that it might that three hundred million doses of the vaccine would be available in January and one billion doses of the vaccine would be available thereafter AstraZeneca says that they plan to not make a profit on their vaccine water is expected to slowly receded mid Michigan state and federal agencies promised to send assistance in the form of relief funds FEMA and the National Guard are moving in to help thousands have evacuated from their flooded homes to dams failed up third sent water cascading through the region conjures along several lakes and the tenable wasi river are going through the wreckage the full time neighbors that I got it was it was it was grabbed the kids and go to the damage for the whole area around here is is just as it is just tremendous the devastation wreaked by the collapse of the Eatonville damn followed a sixteen year long battle between the dam's owner and the federal and state regulators that ultimately failed to bring that dam into compliance boys hydro bought the damn a twenty oh four failed to make the needed fixes and the company is sued the state in April twenty April of this year in twenty eighteen the federal agency is revoked the dams license for the dams hydro power generator governor Whitmer says she expects help from Washington I'm I've been in regular communication with the federal government I will continue to do so my my hope is that the ordinary red tape and things that need to be done in a situation like this perhaps we can cut through it because a covert nineteen has got.

AstraZeneca AstraZeneca FEMA National Guard wasi river Whitmer Washington Michigan