35 Burst results for "Aspirin"
After FDA Set Back, AI Driven Drug Company Advances with New CEO
"Joining US pleasure beer. We're GONNA talk about far next. It's unique approach to drug discovery and its efforts to develop a therapy for the rare degenerative nerve condition shark Marie Tooth Syndrome. A let's start with the company's platform technology though and its efforts to discover what it terms, his cleo therapies what's meant by the term cleo therapy. Therapy. Comes from the idea of field tropic meaning that that there are often multiple pathways for any drug to follow. In fact that most drugs don't act on a single target but rather act on multiple targets. So for example, we all know that you know aspirin can treat a headache, but it also can. You know prevent clotting by. Platelets from forming clusters that. Eight including so. Many many approved medicine have multiple pathways, and the concept here for us is that diseases are not. Just single genetic kits that that that does exist. But often I'm diseases are the result of an imbalance between multiple pathways and insofar as multiple drugs acting on multiple pathways can correct that that's been the goal of far next our work we call it also polly pharmacology. This is a data intense platform uses a I. How exactly does it work and what's the range of data that draws upon? Well it starts with essential genetic data or G wash data. and. What we aim to do is look at a specific disease and look at the genetic lesions if you will within that disease and then all the pathways that are affected. When there is a genetic lesion liken charcoal, Mary Tooth, and then by looking at all those pathways, we can figure out which drugs or which molecules might interact with those pathways in start to put them together in combinations insofar as the combinations provide. A novel and non obvious exciting results that are true synergies. Synergies meaning that the result is greater than the sum of of each response and we do that with a lot of data. It's a lot of data inputs in a lot of a inputs and a lot of experience in pharmacology by our experts. Working at for next on our teams in. So with a multitude of approaches knowing that the output are combination medicines as opposed to single medicines, we've been able to achieve I think some some remarkable results. The company is focused on using this platform as a way of repurposing combinations of existing therapies. What's the case for doing this from a time cost speed on view? We in the past have I'm combined existing medicines although I would say going forward in the future we'll probably. Use a novel molecules are new chemical entities, so-called ease as the combinations of new medicines. It does afford when you're using existing medicines and much more efficient process however, simply because these medicines are already safe and well tolerated in so you can put them into clinical trials right away in advanced trials and get towards the FDA, an approval usually much faster than starting with a lot of the toxicology work that you have to do. With new new molecule. So it has been for us an inefficient process generally should be inefficient process, but most importantly, it should bring new medicines to patients and caregivers that they haven't seen before. You're focused on neurological conditions. This is an area where there's been great frustration. diseases have been somewhat intractable I. Think of what's happened in the area of cancer in terms of the use of combination therapies is that part of the rationale here that combination therapies are what's going to be needed to address diseases like Alzheimer's on Ls? Right in in diseases like Alzheimer's for example, you know there may be one or two or three. Causative factors but ultimately, it causes a significant imbalance in the brain and rather than addressing the first domino, which is still a huge debate in many companies in among many scientists, we often think maybe by making combination medicines, you can address a lot of the more downstream. Activities. That have resulted in the balancing that could be readjusted. So so as we can make a better new equilibrium with that new equilibrium, hopefully modified disease as we've done. Well. Let's talk about.
After FDA Set Back, AI Driven Drug Company Advances with New CEO
"GONNA talk about far next. It's unique approach to drug discovery and its efforts to develop a therapy for the rare degenerative nerve condition shark Marie Tooth Syndrome. A let's start with the company's platform technology though and its efforts to discover what it terms, his cleo therapies what's meant by the term cleo therapy. Therapy. Comes from the idea of field tropic meaning that that there are often multiple pathways for any drug to follow. In fact that most drugs don't act on a single target but rather act on multiple targets. So for example, we all know that you know aspirin can treat a headache, but it also can. You know prevent clotting by. Platelets from forming clusters that. Eight including so. Many many approved medicine have multiple pathways, and the concept here for us is that diseases are not. Just single genetic kits that that that does exist. But often I'm diseases are the result of an imbalance between multiple pathways and insofar as multiple drugs acting on multiple pathways can correct that that's been the goal of far next our work we call it also polly pharmacology. This is a data intense platform uses a I. How exactly does it work and what's the range of data that draws upon? Well it starts with essential genetic data or G wash data. and. What we aim to do is look at a specific disease and look at the genetic lesions if you will within that disease and then all the pathways that are affected. When there is a genetic lesion liken charcoal, Mary Tooth, and then by looking at all those pathways, we can figure out which drugs or which molecules might interact with those pathways in start to put them together in combinations insofar as the combinations provide. A novel and non obvious exciting results that are true synergies. Synergies meaning that the result is greater than the sum of of each response and we do that with a lot of data. It's a lot of data inputs in a lot of a inputs and a lot of experience in pharmacology by our experts. Working at for next on our teams in. So with a multitude of approaches knowing that the output are combination medicines as opposed to single medicines, we've been able to achieve I think some some remarkable results. The company is focused on using this platform as a way of repurposing combinations of existing therapies. What's the case for doing this from a time cost speed on view? We in the past have I'm combined existing medicines although I would say going forward in the future we'll probably. Use a novel molecules are new chemical entities, so-called ease as the combinations of new medicines. It does afford when you're using existing medicines and much more efficient process however, simply because these medicines are already safe and well tolerated in so you can put them into clinical trials right away in advanced trials and get towards the FDA, an approval usually much faster than starting with a lot of the toxicology work that you have to do. With new new molecule. So it has been for us an inefficient process generally should be inefficient process, but most importantly, it should bring new medicines to patients and caregivers that they haven't seen before. You're focused on neurological conditions. This is an area where there's been great frustration. diseases have been somewhat intractable I. Think of what's happened in the area of cancer in terms of the use of combination therapies is that part of the rationale here that combination therapies are what's going to be needed to address diseases like Alzheimer's on Ls? Right in in diseases like Alzheimer's for example, you know there may be one or two or three. Causative factors but ultimately, it causes a significant imbalance in the brain and rather than addressing the first domino, which is still a huge debate in many companies in among many scientists, we often think maybe by making combination medicines, you can address a lot of the more downstream. Activities. That have resulted in the balancing that could be readjusted. So so as we can make a better new equilibrium with that new equilibrium, hopefully modified disease as we've done.
Trump calls for drug tests before Biden debate
"The president trump has spoken to the Washington Examiner yesterday in the Oval Office and he saying that he would like Joe Biden and himself to take drug tests before the debates begin next month. And they asked him why do you think that Joe Biden might be on drugs INCAS, listen I I'm pretty good at this stuff. He says that Joe Biden performed very well during the debate against Bernie Sanders and he said there's just no way. He can pull it together that quickly let's bless you. Nice little sticky. Your. Trump says he takes one aspirin a day, but he would like drug tests. The V. Before the debate start I think it's at the end of next month and to September Well, you know what he's doing, right? No he saying Yawkey accused me of so much stuff out of nowhere. This. Just so ridiculous even even trying to get me out of office with impeachment and all these things that were made up none of it ever. True. I'm. GonNa Start Making up some stuff on you I'm just going to start coming up with things out of the blue. To throw a show, see what it's like. He did have an interesting about the debate. He said, well, it's a prize fight. It's no different from gladiators except we have to use our brain and our mouth and our body to stand I want all standing. They want to sit down which I thought was an interesting thing. I WANNA be standing during the debate. They won't have chairs so I duNNo. A lot of posturing at this but the part of that is strength. Of, strength. vice. President Cheney has major major heart problems. So when he was in the vice presidential debates when it was he and Bush were the the team. He had to sit down for his because of his heart condition and that was part of the agreement with that. But if you're not, if you're not having, you know if you don't have any kind of health condition that would prevent you from stain I thought they would do. You remember or not but. I thought they would do several debates in several different ways like one would be standing. One would be sitting would be a town hall kind of setting the way I, remember there there are stools and when it was your turn to speak, you would stand and or and so that with the other person was speaking, you'd go back and sit on your stool. Then when it was your time, you would stand and. Come forward to speak to the people in the room that was one of Hillary Clinton's big complaints about one of those debates where they had the stools in a town hall setting and instead of when he was done, he wouldn't go sit back in his chair he kinda stand eight feet or so behind her and just kind of pace back and forth and she said she felt at ver as like it was. What do you call that? He was talking her coming like he was stalking her and trying to be you know what that's called that's called Gamesmanship. What people do he figured out? I'm not going I'm going to change this up. I'm GONNA throw her off her game by I'm not GONNA, sit? I'm going to stand. It's it's it's strategy. Yeah I. Remember when I remember this because I'm ninety one years old. But during the Bush Al Gore debate when they were doing the townhall went on the stools and Bush, was answering a question that was asked to him and Al Gore. Walk Right and got in his face. And he stopped and looked at him like Hey. Buddy. And then just went on with the stuff was a great. You know you've got a good laugh out of it. I mean he taxes he's privacy going. Hey if you get on my space yeah, I, remember that because it was a big deal that. Gore tried to intimidate him in Bush just kind of made everybody laughed in Gore had to step back and then it. A mistake that Al Gore may again, they do all kinds of that little strategy game what they say when they shake hands, what do they say because a lot of times people will say something to kind of make you reek wha, what did that mean rise to make you think before you start but in the the the Romney Campaign Against Obama that vice presidential debate biden wipe the floor. With the what's his name? The Republican? He was the speaker of the House and he he's a Paul Ryan. All Ryan. Yeah he's a he's a fake. Yeah. Fake conservative. And Yeah Biden. whipped him in the debate. Yes. So he's he's not a bad debater if he's if he's Going on his own. So the strategy begins now I guess, of course,
Kimye's Make or Break Vacay, Kylie Turns 23 & "WAP" Backlash
"Okay I. Stop Word on the street is came and Connie has had an exotic getaway with all of their kids to work on their marriage. Of course, we are rooting for them but this is a move lots of stars have done. With mixed results in the past, do you guys think couples know deep down if they're gonNA, make it before they go on these trips or do they just convince themselves that the trip is going to help and they're gonNA work now I think they go like they go intention of it being you know helpful beneficial but I think you know sometimes you go with the Kevin shoot ever like plan something to the t. like vacation or something and everything just completely goes wrong. So you go yeah. Intention of having an amazing time and then you're like Oh, this is a nightmare. Happens I mean I went on a trip you know at a point in my last relationship where I thought Oh we'll get. We'll have a weekend away. It'll be a nice distraction but I knew that was over. Over I think certainly with Brad and Jen when they went on the trip, mean Brad New I'm different out of the marriage because Indian is waiting for me. So I think in this case I think it's a real effort and I think that these two. Are Working on their relationship these celebration vacations that people go on. Solving. Feel like. Hashtag. So Schmidt shirts salvation vacation. I think that if you're going to go on that either you guys go in with this intention of fixing it or really is that last like Lettuce Ryan Save this. But if you're just going in to try and like you don't really WanNa fix things because you know deep down if it's for over one hundred. Going and you know it's over it's just you stuck in a room with less distractions and you're forced to like deal with those things you don't like anyway. So. Really ought to me you gotta be ready to work or thinking. I'm going to do everything one last time I'm going to get one last hookup in I'm going to get you know one last hugging. The other person is thinking I, want to try to save this. So you know you have to go in with the statement engines. Meanwhile, Kylie is thriving as all know it is her twenty third birthday today and we show many questions I mean what the Hell is this I'm GonNa ask you because I don't think you care that much about flowers. Would you this flower display this sort of bizarre flower display or do just want some normal roses? It looks like upside down pineapple. No I No and House. Yeah. I watch. This in my house is taking up the whole first floor like. She has a house big enough to hold it but like this is not going to work in my house in two miniature versions, it's really impressive. If just consider how many flowers that is the craftsmanship that goes into it. Feels like it should be at some sort of like of event like a homo. Championship, where people are walking around like there's thousands of people story she had this. Little white you're doing you're destroying hundreds of flowers. One person to enjoy maybe a few people. If it's her family, it's just a lot and can no. Aspirin and they're known for the over the top flower installations. We see them at every holiday every Valentine's Day every birthday and they're usually really beautiful. This is the first time that I'm kind of like does she like like I don't know even her style and it does now I can only see pineapple also she's sending these to herself right? Like we don't think someone sending them to her. It's not like with she knows her cell like she I think she I don't think she's sending them to herself I. Think She's setting these things up and she's like mom it's my birthday and I need to have a happy birthday Kylie by the pool. Like this standard this is like brushing your teeth rally you would send your own like Happy Birthday, Senate Oh. I am that desperate I. Don't know why you think I'm not like I as McQueen of just doing anything to make myself looked a little more love look. Yeah. No I would do it anything. You'll see. Meanwhile and everybody was going crazy over Cardi me and meg. Song Walk, which stands for I'm just kidding, but it's not all good. Some critics want to ban the song saying it's too sexually explicit vile and quote sets the entire female gender back by one hundred years. So dots on this guy's what he thinks about this. A both. For those that don't know. Stands for what? Is. but in terms of their argument at this is setting the female gender back one hundred years. The female gender was way far back on hundred years ago, and it wasn't because they were embracing their sexuality and taking control their own bodies because other people aren't doing it. So if anything's GONNA, take the female gender one, Hundred Years Back. It's someone telling women what to say and do like they're doing right now. Man Who tweeted his criticism of it and says that he watched the video accidentally I how? Do you watch this accidentally you accidentally watched it over and over on repeat on. Youtube. In, other news five in cows recovering after breaking his back in his home in Malibu hikes he hit up twitter after a six hour emergency surgery saying some good advice. If you buy an electric bike, read the manual before you write it for the first.
Cyber Safety, How to keep your identity protected using mindfulness and practical tactics
"How you doing Sandra? Hi. How are you doing? Thank you for having been your show. So, matty here. Right absolutely. So we're talking today about identity and cyber. Theft here. So give us a little bit idea on what that's about what does identity theft what is cyber theft? What does all that stuff? Of course? Let me start why I started. Niger, any may be. Definitely will get into into whether they cybersecurity are cybercrime or identity out. That okay with you. Sure. So I was returning a many many years ago I was returning from these things. Colombian. So I mean, the plane were landing in Miami and the pound announces that Homeland Security. Were boarding the plane. I course to ask for a handed to the to the agent and at the time I, head out these. It was relocated recently to the US. Ns I had my passport to the agents. then. He's next thing I know I'm the only one that being score of the plane by the two officers. And enthroning to the room you the. Famous rooms. that. Are In airports in I, don't know what's happening. Out. I'm about to connecting fighting my husband's waiting for Chico. So ten hours later and handed back my passport and is revoked. Few weeks later I mean Venezuela my native country and I'm trying to process my. Mom to processing again, you sign I had a lot of support from Maya Turks from my former employer journey. So we are in to again and. It was interesting officials. They kept asking me about China. Why we're doing China. China who is your contact? Like I never been in China. beating know what they were talking about. Some how when? S Model China go to hold of my information and was smuggling women into the US using my identity. Yes. So humid slate, you know everything I convinced, of course, a smuggler I gave my new visa and a back home two weeks later and returning from Euro my job requirement to travel a lot. And as we are going to. Control. I. Give My passport booth. I'm right back into that room. Because I have to. The, real me over and over that for six years. Yeah. So when I going everything was Chinese I. Mean it was really crazy at nobody wanted to travel with me a united in my almost wanted to travel with me. and. Finally. made the citizenship, my aspirin I changed my. Everything Courses Okay and at the time I was working tonight not. Having in the industry for over Twenty Years Community? It non no it was identity. It was not in the news. He was not like every day right now at breach or cyber drive or this or that. Back back in that day in that time, it wasn't so I couldn't make the connection. So few years later, I changed my career and I join cybersecurity cybersecurity? Area. Industry. And I realized what happened to me, and what happened you know when someone takes your identity with Tony, personage you for their gate. and. You know eat my corporate career I did that I? was very passionate about. Training and education awareness and Allison Park job that I enjoy the most. So I wanted to Redo it at a bigger scale as I left my corporate all by did your original question about what is at Know when stolen takes something from you. And wince when they break into your life, and that can be very dramatic experience and it can be for many reasons financial reasons it could be for. Someone inside your company that has. Either made a mistake or by attention. Jober that is you and ninety. Attack you could be for like in my case, there was a vying for for that criminal to have my identity so he can use it for him. So there are many life happens. It's It goes on all the time. We don't always hear about identity theft on the news I might do commercials about it. You know when the advertising different products, but it's something that a lot of us don't even really hear about. So how does that happen? How does someone? Get your information. So you can happen. Through many different things that can happen through your social media, it can happen through your email can happen through when you give out your credit card in a restaurant. It could happen when when when you ride formation with with a doctor. Often, office I mean, there are so many ways. Jury information can be obtained. We share a lot in social media share. Many different things. That are personal and that that is one thing that can use. Of you do that. You know sometimes we don't hear the news a lot about identity issue i. think we should do a because there's a new victim, every two seconds. A new victim I mean someone right now? has just being victim of identity DOPP and there's different decrease appointed. You know sometimes we someone let's say takes your credit car. And data charges in your credit card and probably most have had situation and the bank context you. Just have to get a new credit car. Scare of it. So it's a degree of identity theft is in the financial. Hesitation of identity theft, but it is. Your credit car on and bought things on your behalf. But it wasn't as faithful as many other situations are obviously. More were personnel or or moines more invasive.
UFC 251: Kamaru Usman vs. Jorge Masvidal
"Island becomes a reality. Well, I guess it's already a reality. But there will actually be fights there, and it's actually Gosh! Maybe one of the best certainly form in my opinion, the best card they've had since they've come back the UFC But really good card. A lot of big names. And then, of course, the main event of the evening is a fight that Probably should have been on the card anyway. What We ended up plucking out, I suppose. With Moscow it all being put in against Guzman. So I wantto talk a little UFC 2 51 Maybe Look at some of these potential wagers and get Ah Someone who used to frequent this show. It needs to come on on Maura, and that's on me. Scott Kanevsky joins me now, Scott. Good to catch up, man. How are you? I feel like a first time long time been awhile. It has been a long time. And how are you? How's the family? How's everything going doing well, and I appreciate you having me on thinking about me and things were going well, and things are only gonna get better tomorrow night. Yeah, absolutely. Did you laugh at Dana White when he said when he first brought up Fight Island? Yes. And no. Because you know you crazy enough that he was probably speaking the truth. You figured, you know, maybe he has something going and he's crazy enough and has the money the backing toe pull something off like that, And sure enough, here we are. I mentioned at the beginning How good this card in is and it's not just mustered all versus Guzman by it. Man. Did we luck out? Right? I mean, my you know, I feel bad for the dude who had to pull out and it doesn't get a fight Guzman tomorrow but as a card, it's so much better now that master dolls on it, don't you think? Agreed. Gilbert Burn, We'll get another shot at some point. I mean, hopefully next in line for whoever wins tomorrow night. But this is a fight Everybody wanted. You know, already. Mas Vidal inducement aren't exactly the best of friends. They've been talking for a while. They had that the altercation back in the states. It was Super Bowl on radio row. So this is something everyone's been wanting to see. And now with Byrnes Contracting Cove it we're going to get it on. I think that's just made a already really intriguing AA fight cars that much better. Now I got burned by Justin GHT because I was all in on Tony Ferguson in that fight like it's not gonna happen. It's not gonna happen twice, right? I mean hospital is not gonna win. This thing is he Okay. From a mm a standpoint, I have to say no. And I would agree with you. But if you're going to talk, betting going all in and you've seen what's happened over the last 24 36 hours. Money is just money and tickets are pouring in on Mas Vidal. He's he's gone from about a plus 2 25 plus 35 to a plus 1 85 last I saw earlier today. I believe there would be MGM believe put out there that they're taken 81 ticket being booked for Mas Vidal. And you know, you know what they say. You gotta follow the money. So it just Somebody knows something, or is it just It's obviously not just big bets that are coming in on Mas Vidal, but there's no number of that's coming on him. And that just makes you wonder if someone I'll be just like you know where agree like you. It was all set up for Tony Tow. Go in there and handle him and take him to the ground and didn't but You know, maybe he'll learn from that. Now. What's what's mobs but all going to be able to do to be Guzman. That's the big question. You know, he's better on the feet, obviously, but you know who's going to try and take him down and out wrestling? So How? How does Ma's little battle that and managed to Ah, toe? Hold him off? I don't know. I think I'm right there with you. And I just looked at Fanduel and they have mustered all that plus 200 right now. So even though that's a little bit longer odds, then maybe MGM has that still down as you said Scott from 2 25 or something like that just a couple of days ago, and I guess oh, so let me ask you this if we do the betting thing I I have Guzman minus 2 45 or mosque it all plus 200 Or and then of course, you could get into it. Um, I took in my parlay. I took Guzman just straight up because I got enough other stuff in my parlay that I'm going to get pretty good odds out of it. But if you were laying down, Abed, would you would you do it smarter, Would you Dumas fit all Okay, so I would I would wait until about 15 to 30 minutes before fight and see where those odds are because of who's come down to, like, minus 200. I think you jump on him because they're getting more value for him. And firstly, I think he does come through with the wind, and he's just going to grind it out. But if that money starts about bounce backto mas Vidal, you know, I think, and you're looking to take a shot. You're willing, you know, maybe you had a good night on the earlier fight. Maybe maybe you going on and on and you take that shot. Just hope he comes with that flying me. He landed on aspirin
Bayer Agrees To Settle Thousands Of Lawsuits Filed Over Its Weed Killer
"The maker of Bayer aspirin is finally ending most of the lawsuits it inherited when it purchased the maker of roundup weed killer they are AG has agreed to pay more than ten billion dollars to settle hundreds of thousands of claims that the weed killer
Bayer to pay up to $10.9 billion to settle Roundup lawsuits
"When the maker of Bayer aspirin purchased the maker of roundup weed killer it inherited well over a hundred thousand lawsuits over batch roundup weed killer there now says it will pay as much as eleven billion dollars to settle a majority of those claims that around that caused cancer there are also plans to pay more than a billion dollars to settle claims related to PCB compact contamination and contamination from another
Army open to discussion on renaming posts named for Confederate leaders
"Defense secretary aspirin army secretary McCarthy have signaled a willingness to discuss scrapping Confederate names on forts across the country there are ten army posts named after Confederate generals all across the south and there's a big ones Fort Bragg in North Carolina Fort Benning in Georgia and Fort Hood in
Revisiting the Archive: Larry Kramer
"I've talked before in this series revisiting the archive about anger. How it can fuel action? How an anger is partnered with love? It can produce a kind of righteous rage that propels us those of us who lived through the AIDS crisis. Know about it. Some of US learned it from Larry Kramer who died this week in Manhattan where he's lived for. Decades Larry was famous for being one of the first billions to sound the alarm during that last epidemic. The one that began forty years ago he was on the front lines even before aids was called AIDS and became a global epidemic at swept away more than thirty million lives before AIDS. Larry was best known for his work as a screenwriter and author but the virus that was claiming so many lives in the political indifference political negligence that greeted it turned Larry into a very public activist. His friends were dying and he felt compelled to do something more than to just bury the dead and mourn their loss in nineteen. Eighty-two Larry co-founded a gay men's health crisis now known as GM five years later he co-founded act up the AIDS coalition to unleash power. Act Up came to be known for its brilliant use of public protests to bring attention to the epidemic by early nineteen eighty nine. When I I met Larry AIDS take in more than sixty thousand lives. Most of them. Gay Men Larry quickly earned a reputation as an uncompromising firebrand with a fierce temper. I'm not proud of it. But that kind of person generally inspires me to run in the other direction. I was more than a little anxious. I approached the door to Larry's apartment in a building that fronts Washington Square Park in New York. City's Greenwich Village. As I said when this episode originally aired I got myself worked up. Nothing I brace myself for a tornado and found the teddy bear. Here's the same. Larry welcomed me into a spacious apartment and showed me into his all white book line living room and I took a seat opposite him across a broad desk as I said at my tape recorder and attach the Mike to his shirt. We talked about how we both had wanted to find a husband early in life and settle down and that led us back in time to Larry's memories as it confused and Unhappy College student in the Early Nineteen fifties. I pressed record interview with Larry Kramer Thursday January twenty six thousand nine hundred eighty nine at the home of Larry Kramer in New York City. Interviewer is Eric. Marcus tape one side one. When I went to Yale I thought I was the only gay person in the world and tried to kill myself because I was so lonely. Did try to What am I think that was fifty? Three was the year my freshman year. Yeah is awful. I mean I do want to go back that far curious because I was a college student on seventy six desperately unhappy. We're at Vassar College. There were there were a lot of gays. They weren't that many people think there were a lot if there were so many gays. Why was I so unhappy? Miserable person and And deaths seemed very appealing at moments during my freshman year when I was dating a woman in making off the man by in life and fifty three must have been much more difficult than seventy six at Vassar. You can even start in shifty. Three Easter I knew I was gay. I think from the day I was born and I think that there have been I. I now know that there were isolate. They were experiences all through before. I even got to Yale. And they were all covert in guilt. Inducing on on everybody's part so the it seemed as if all those early years were spent trying to deny these feelings the feelings would sort of get to strong erupt in and I would have an experience. Which would autumn always make me feel guilty in one way or another and then you put it you become. Sylvia's would come down for a while a week a week or two and Yale was awful. There was a gay bar called parolees. It was awful the time when I finally have the courage to go there. It was only two blocks from campus. But it was a million years away. It was very dark and grey and inside and smokey and and filled with old old older man and I only went the once and somebody picked me up. A car drove for like hours before we found a place that was quiet to do it and then he drove me back where you didn't say a word all of that list of yourself. I eight two hundred aspirin. Oh my God talk about slow and Miss. You must have been pretty miserable to swallow two hundred and yours anymore. Will after you wanted out. Was that who knows. It's a scene. I'll never forget the scene of taking pills the Yup and find you're still better. I didn't wake up. I I went to bed and I got scared and I call. The campus. Police came took me to the hospital and put myself and that was in woke then I fell asleep and I woke up in a room with bars and after grace new haven hospital and there. Was this very unpleasant hospital psychiatrist. Who said all right Mr Cramer? Why did you do it and I go fuck yourself or words to that end he said? I'm now you're not going to be let out of this hospital until you tell us why you did it. And I just had a few rubbed me the wrong way and I wouldn't have told who who knew why I did it anyway. So my brother who's always sort of looked after me came and got me out and he was friends with the dean of Freshmen. My brother had been the before me and And it was you know ordinarily when something like that happen you were shipped off to go join the army really in those days. Yeah and then you come back to Yale and you've grown up but they let me stay. If I went to the University of Coyote. Just his name was Dr Fry Clement Fry. And he was about in the sixties he had silver hair and it was a good looking man he whereas reptiles button down shirt and You just knew that. He cared more about Yale and he ever did about you
Making Your Market Category A Must Have
"Welcome to lock it on marketing where we're trying to world first marketing pod stormed thirty days of strategies and ideas to help you create the future of your choosing Heyhoe. Let's go thanks for pressing play? I'm so glad you're here on this episode. Let's talk about arguably the most important issue facing your marketing as you go forward powerfully and that is is your category. A must have a nice to have or a door really need to have. I hear a lot from CEOS and CMO's Long lines of our problem is that we're too much of a vitamin and not enough of an aspirin. You see it turns out the more strategic the more valuable and the more urgent the perception of your category the greater the chances are that customers will prioritize your category and therefore your company. Your brand your product your service and as a result by from you and I think there's something very important to understand about what's going on right now in the economy. We are all in a game of Wallets. Share much more than a game of market share. That is to say customers wallets as a result of the recession are much smaller and so they are going on a prioritization deciding what's most important and what they can live without. So that's what we want to do. Today we're sponsored by my good friends at Oracle net suite visit net sweet dot com slash different today to get your copy. The paper managing business uncertainty and schedule. A free product tour. That's net sweet dot com slash different. And my friends at spunk. Are here to help you with the power of data because spunk is the leader in data to everything visit spunk dot com slash. Di The number two E. as in data to everything and learn how to turn data into doing and also. I want to remind you go to lockhead DOT COM L. O. C. H. E. A. D. and sign up for our newsletter. The difference we've invested a ton. There were sending you a bunch of awesome stuff. It's free and will never ever sell your email address. All right becoming a must have is number one I think. And here's the mistake that I already see. Companies Making as as the economy starts to open up their evangelizing their brand not their category. And here's why that's such a fundamental mistake. Our brand is about us is about. Our company is about our product. The category is about customers their problems their opportunities so categories are about customers and brands or about us right now savvy. Marketers are focused on their customers and making their space their category critical. And let me give you a couple of simple examples The Washington Post by way of example has a very powerful tagline and their tagline is democracy. Dies in darkness? Now what are they not saying? They're not saying. Hey The Washington Post great Great newspaper by our Shit. That's not what they're saying. They're laying down a point of view about what they believe about democracy and they're they're sort of evangelizing. This point of view and as a result elevating the value of A free press so. They're not marketing themselves per se their marketing the power of a free. Press with the tagline. Which you could argue is a point of view. Called Democracy dies in darkness. Another simple example is dollar. Shave Club Shave. Time Shave money so they are evangelizing shaving and using them as the answer to shave and right now a lot of us because we're staying at home aren't shaving very often. And so they're trying to elevate not just themselves but the category shave time shave money and maybe the greatest category elevating category evangelizing campaign of all time came from the California milk processing board and their legendary campaign. Got Milk and they're trying to elevate milk as a choice of beverage there as opposed to other choices. So now's the time to evangelize your category. Not just your bran. The other interesting thing is the way that human brain works is If I think the categories important then I go to the brand the number one brand. And here's an Aha that almost nobody will ever tell you if your the company or the person evangelizing the category talking about. How awesome Newspapers are talking about how awesome getting. You're shaving shit over the Through the mail is etcetera People will assume your the category leader. So there's an interesting thing that happens by evangelizing category and keeping your brand more in the background. You also elevate your brand above everybody else in the category because in the mind of the consumer in the mind of the customer the company or the person evangelizing the category must be the category Queen or category King.
Tough Airports with Pilot to Pilot
"I'm GonNa Bring Justin. See here he comes. Hey there's my man has then. Are you actually looking up at four flight up with my computer? And I was looking up bested when you're talking about it because I know seen it before in my mind is not like I don't even know if I WANNA fly. They're like Oh yeah. You know it's funny. Some sometimes that stuff's really intimidating but the rules you have to follow making for example. If you're coming down through Elgin and Valparaiso there I think it looks. I mean obviously be having to talk to their tower Roy. Once you're talking to their tower than your you know everything's Kinda worked out for you with the floor capabilities. File Easier that's funny. I was going to ask you about that because you're flying into so many different types of sorts. That's pretty much what you guys do. All the time right. It's just file a far. Yeah we will most are flights Are we can't take off the far far up in the air but we like to keep it many times. It's awesome just because it does help the have. Atc talking to you. We're GONNA get a busy airports. I never even expected to be really busy. There's one in Minnesota really crazy student training area. And there's like six or one seventy two pattern at a time mixing via far in just the Afar general. It can be a lot safer going I- Afar when you have the opportunity to do so. Yeah I totally see that Aspen. Airport there any over. It's like that that you guys going to where your company says we're GonNa have to do extra work with you guys or you have to fly in their inexperienced captain. I or something like that. We do similar trading on ask than we have a whole like Aspen lesson where we have to to land at Aspen. Show that we can do that. Another one's called Ocean research is a private airport down in Florida. And it's a really skinny and kind of severi interesting airport which we have to get checked out in the simulator. I I think we have to do it. Every every couple of years just to get retrained because our wings actually hangover the hedges when we go into land so it's very interesting but it's a very popular destination. While can you say just briefly? What's so challenging about aspirin? I that's SORTA aspirins just very interesting place. I mean if you even just look up the approach tar and you can see the glide. Slope like seven degrees. Maybe maybe it will literally feeling like you're going straight down at catch it. The site pictures just so messed up and then you have like a mountain right here. Airports a little bit farther forward. You can't get the glide slope warning fear when you come here I. It's hard for me to really explain it unless you're going. There are other chart in front of me. But it's there's a lot going on at Aston you gotTa be under your pointed down so far that you're speaking to come even if you have the Steve Breaks out so it's a very interesting airport for sure. Yeah that's wild. I mean we flew in there all the time in one. Eighty Two's mountain checkouts in Eagle Aspen than through loveland. Pass out toward lead though and all that now one eighty two. It's not a huge big deal. It's totally different. When you've got a jet can handle up pretty well so it's not too big of a deal but it definitely interesting. We don't take it down to the purchase so that we have the the airport site at a certain fixed remember. Stop ahead now. But we have special charts going in there and then. There's some other mountain airports where we don't need to be checked out in but we have a special area in our. Aol were read up about it before released before we go so we know the challenges that airport could cost. That's interesting I think. The last accident I remember at Aspen was a challenger from that mistake and landed with a tail rent. That's yeah that's very commonly. I WANNA say they landed on the taxiway almost other grass remember astronaut now or another airport. Another airport was. They didn't know that the runway was just pay. They thought the runway was covered in snow so they saw a freshly paved runway but their mind. They thought that it was supposed to be snow-covered sir. Lynden to the right or to the left of the runway landed on grass. Wow that's so fascinating that you just said that because somebody else I think it was. Brian Shift pigmy the other day he was doing lecture for Nasty. Just wanted to know if I thought about something. He was calling expectation bias in training right and I didn't really know any man I was like. What do you mean by expectation bias? And then he told me a little more it was basically what you just described. It's like how do you deal with when your mind is set on seeing one thing? That's what you're expecting. And then something different is happening and to be honest. I don't see it very much in training but what you just described was perfect. Exactly what the talk about do you guys talk about that at all in your training that specific conflict We'll make a big deal about going over all the threats that could be going on so as soon as we brief all the threats. We kinda talk about all the threats. This threat might be kind of one that comes up on the fly. But if there's ever a moment where you feel any kind of confusion or you feel any dow it's like immediately go around this. Go take off. We'll talk about last hour. The runways taped or not paved or regain rebrith. We WanNA do. We can go somewhere else. We can talk about some things especially to ask them because the weather changes so often. We have a very strict kaylynn limit were. Some operators may be part ninety one. Maybe they don't relate abide by that but we do not go in there with a win more than two not talented. So if we're coming down on finally tell us that the tailwinds do high will do out and go around and go somewhere else. So it's definitely safety. And you always going to err on the side of safety so one person was real comfortable. You go out now. That's awesome and there's two things that you just said that I always hammer on my students about so I just have to act on. One wasn't aboard point where you're talking about having a certain way point if you're not on glide path through or whatever then it's just an automatic and the other is that a superior if it's eleven knots. Tailwind you're out you don't think about it. It's not ten anymore. It's eleven soared on once really good. That's good stuff. I feel like so many of those things that we can cement those for GE pilots. You know there was a guy that flew into Palo. Alto in a mean. I don't know if you've ever flown a Moonie but it's like doesn't want to stop flying. I mean not only. Is the wing like six inches off the ground at slamming her flow. It won't quit and twice in my career I've seen people come in and Mooney's and just go around late in one case and hit the trees on in this last case Palo Alto literally just floated till he went right off the end of the runway and that was a fatal accident. You know people say like what would happen. How could he avoid it? I mean abort point in any airplane is a great idea right. No absolutely and it's something that like you said when you drill down and generally aviation to create that kind of mindset. You always think that it's not going to happen to you but it can happen to you. You're gonNA find yourself in this situation. You don't feel comfortable. Then you gotta go around just like no if saying like you can't succumb to that mindset
My Panic Attack
"Originally intended to record this episode back in March but that's when the corona virus hit the US in full force. So I put it on the back burner to host live. Qna's instead highlights. From which are uploaded as podcast episodes but once our front doors open again. The sudden stimuli of crowded stores and roadways might overwhelm us which brings me to this unlikely story. I want to share with you about a panic attack. That had earlier this year it turns out. There's a good explanation for why it occurred but it was quite unnerving when it was actually happening. What got me through? It is what can get us through. What's happening right? Now after? Six years of accumulating airline mileage points from flights and credit card charges. I finally had enough points to cover an absolutely free round trip. Flight and five week backpacking trip around the Philippines earlier this year and setting up a tenth on the beach or as I like to call it. A five billion star hotel made the trip in nature lovers paradise but quite a few shots. Vaccinations for things like typhoid and malaria were either necessary or strongly advised prior to boarding the flight. I am fortunate enough to not be on any medication. generally avoid even taking aspirin unless. I'm in severe pain but considering all the time I was about to spend sleeping outdoors in a third world country. I took the malaria pills for two weeks prior to departure as well as during the trip and for three weeks. Afterwards I didn't bother reading the possible side effects because not taking the pills wasn't an option but it didn't take long to notice that the pills made me sleepy for example so I just took them at night. I later discovered. They also cause vivid dreams and a slight fever which was no big deal. The whole point of the trip was to maximize time on quiet deserted islands for some peace and tranquility and to avoid major loud cities like Manila as much as possible. Since as far back as I can remember. I've been hyper sensitive to certain types of noise. The high pitch of CRT monitors beeping alarms the sound of someone snoring chewing the auditory assault of emergency sirens screaming children wind chimes and even certain. Birdsong would all drive me crazy. If it wasn't for two things one I can usually meditate and breathe deeply through the noise until it stops and I can return to the bliss of silence and to almost always have earplugs on me just in case. The sound is louder than my meditation consumer. Whether this miss a phony ah is a symptom of being somewhere on the spectrum or something else. Altogether avoiding noise isn't an option especially when dealing with major airports and public transportation. I can usually gear myself up prior to leaving the house in preparation for what's to come and wear noise cancelling headphones which more often than not keep my anxiety at bay anyway. The trip involved wonderfully warm ocean breeze on white sand beaches beautiful hikes and surprisingly freezing temperatures did not expect to experience in the Philippines but enjoyed immensely nonetheless on us. Sunrise hike to one of the highest peaks in the country clear blue skies and great food. Add into the mix one bad case of getting seasick on a boat between islands two cases of food poisoning which I actually think was from drinking the water. Not NECESSARILY FROM ANYTHING. I eight and you've got the complete experience which was still great in the grand scheme of things but at one point returning to the big loud and busy city of Manila after a couple of weeks of reading books in a Hammock on a quiet deserted beach. Hit Me really hard. The noise of construction traffic blaring. Tv's and radios car horns and the fast pace of everything and everyone around me shot my anxiety through the roof and sent me into the worst panic attack of ever had. I'm not going to play it down for you. I completely lost it. I truly believed it was the end of timber as we know him. That Buddhist boot camp would come to an end and that I would have to check myself into a mental hospital upon returning to the states. If I don't kill myself I that's how bad it was. Suicide was more inviting than another minute of noise from which I couldn't escape even with earplugs or noise cancelling headphones I truly wanted to die. It was my lowest point and I didn't even recognize myself. I mean this is me. We're talking about the guy who feels anger threatening to surface and starts contemplating what other feeling I'd rather choose but in this case this down to Earth Guy you've grown to know over. The years was no more. What got me through this sudden spiral of mental instability. As I was rocking back and forth was repeating to myself. This is temporary. This is temporary. This is temporary within an hour. I fell asleep probably from exhaustion. It's incredible how much energy the body uses to feel something anything so strongly. When I woke up the next day I was no longer on edge but still seriously questioning my mental health. Was this my own psychotic breakdown. His this what everyone was saying. Britney Spears went through in two thousand seven. It felt like years of meditation. Mindfulness and all the practice of had to remain calm in the midst of chaos. Meant nothing so I decided to do some research and discovered that severe panic attacks are actually a common side effect from the Malaria vaccine. I was taking and it all made sense on the one hand. I was relieved that it was merely a chemical reaction to the pills but has felt so real in the moment of panic. I couldn't access all those other parts of my brain that would have otherwise kicked in with logic and reasoning to talk me off the ledge but whether real or chemically induced the mantra. This is temporary. Helped me through it? All temporary can mean a minute or two an hour a week month year or lifetime. No matter how you look at anything. Everything is in constant flux. I guess what pleasantly surprised me. The most is how quickly I was willing to accept my mental breakdown. Prior to falling asleep I contacted a friend to recommend a therapist could see immediately upon returning to the states. I asked another friend whether the mental institutions depicted in movies resembled the real ones. He sees in his medical practice and then all reminded me of the near drowning incident that I described in my memoir and how I'm merely observed what was happening rather than reacting to it. I guess I wanted to share this story with you because perhaps all of the years of mindfulness practice didn't go out the window in the moment of panic and the gap between impulse response. I didn't react to what was happening. I reminded myself how temporary it all was. Mindfulness Meditation can really help us. Not In the moment of meditation but at some point down the road when we need it most a got me through the four hours of being seasick on the worst boat ride. You can imagine it. Got Me through the panic attack and it got me through the whirlwind of change to which I returned when I got back home for starters I found out that I had to move out from where I've been living for the past two and a half years but rather than react or dubbed the unexpected experience terrible or unfortunate. I found a new place to live. That is everything of ever dreamed of. And then this corona virus exploded and I can't think of anywhere on the world where I'd rather be quarantined right now
A Ward of the Probate Court
"Welcome back my friends to the big book podcast. My name is Howard and I'm an alcoholic sober since nineteen eighty eight one day at a time in this episode the Thirteenth Story from the personal stories section of the first edition of alcoholics anonymous published in nineteen thirty nine. It's entitled Award of the Probate Court and was printed only in the first edition of the big book. This relatively short story provides a glimpse of the formative years obey when old timers were those with two or three years sober but whose perseverance and dedication made possible a solid foundation for the entire a movement and now the original story award of the probate court at about the time. My graduation from high school a State University was established in our city on the call for an office assistant. I was recommended by my superintendent and got the position. I was rather his choice in pride but a few years later I met him in a nearby city and panhandle him for two bucks for drinks. I grew with the institution and advanced in position. I took a year off for ten minutes at an Engineering College at College. I refrain from any hilarious celebrating. Drinking War was declared. I was away from home on business at the state capital where my mother couldn't raise objections and I enlisted overseas. I was on five fronts from Alsace. Up to the North Sea upon relief from the lines back in the rest area being rouge and Cognac helped in the letdown from trying circumstances. I was introduced to the exhilaration of intoxication. The old spirit. What the Hell Heine may have you tagged. Didn't help towards any moderation in drinking then. We had many casualties but one of the real catastrophes was the lost of a POW. A lieutenant who died from the. Dt's over there after it was all over. This didn't slow me up and back in the states I had a big fling before returning home. My plans were to cover up with my mother and the girl I was to marry that I had become addicted to alcohol but exposed the fact on the day. Our engagement was announced on the way I met a training camp. Buddy got drunk and miss the party booze had got over. Its first real blow on me. I saw her briefly that night but didn't have the guts to face. Her people the Romance was over to forget I engaged in super active life and social fraternal and civic promotion of my community. This all outside my position. In the president's Office of the State University I became a leader. The big flash in the PAN are organized and was first commander of the American Legion Post. Raised funds and built a fine memorial. Clubhouse was secretary a belks. Eagles Chamber of Commerce City Club and active as an operator officer in political circles. I was always a good fellow and control my drinking indulging only in sprees and private clubs or away from home I was deposed from the executive position at the college by political change in the governorship of the state I knew the sales manager of Securities Division of a large utility corporation in Wall Street and started to sell securities the issues and the market were good and I had a fine opportunity. I was away from home and I began to drink heavily to get away from my drinking associates. I managed to be transferred to another city. But this didn't help booze had me. My sales and commissions diminished. I remained almost in a continuous stupor on my drawing account until I was released. I braced up got sober and made a good connection with the steamship agency. A concern promoting European travel and study at most all important universities in Europe. Those were the bathtub gin days and for drinking in about my office. I held out in this position for only a year. I was now engaged to be married. And fortunately I got another position as a salesman for a large corporation I worked hard was successful and my drinking became. I was married and my wife soon learned that I was no social drinker. I tried hard to control it but could not. There were many separations and she would return home. I would make pledges in a sincere effort and then my top would blow off again. I began here to take sanitarium treatments to satisfy my wife and my folks I had a great capacity for drink and work with the help of Turkish baths BROMO SELTZER ASPIRIN. I to the job. I became top notch or in the entire salesforce of the country. I was assigned to more special territory and finally into the market of keenest competition. I was top rate and salary one bonus awards and was bringing in the volume but there was always the drawback. My excessive drinking made at times I was called in once twice and warned. Finally I wasn't to be tolerated any longer. Although I was doing a good job I had lasted five and a half years. I lost my wife along with my job and find income. This was a terrible jolt I tried for a hookup but I had a black eye marring a good record. I became discouraged and depressed. I saw relief with booze. There began the four black years of my life. I had returned home to the community where I had been so prominent these were dry days still and I hung out at the clubs with bars. I got so I would last on a job but a few days just until I could get an advance for drinks. I began to get entangled with the law arrested for driving while intoxicated and drunk and disorderly conduct my folks heard of the cure at the state hospital. I was picked up drunk and sent there by the probate court. I was administered. Parral to hide and came to in receiving ward among lunatics. I was transferred to another word of less violent cases and I found a little group of alcoholics and junkers dope addicts. I learned from them the seriousness of being award of the probate court. I felt then if I ever got released. The old devil alcohol would never get me in a jam like this again in times of great distress. Such as this I would pray to God for help. I was fortunate and was released after eleven days and nights brought up in the laughing academy bughouse. That was enough. I wanted no more of it. I took a job as a manager of a club and put myself to the old acid test. I was going to really assert my willpower. I even tended bar part of the time. But never imbibed a bit. This lasted about three months. I went to an annual convention of my overseas division and came to locked up in a cheap hotel room. New shoes suit coat hat and purse missing. I must have slipped badly then followed much drinking in trouble. After a few arrests for intoxication the law decided another sojourn to the State Hospital would tame me. They jumped the stay this time from eleven days to eleven weeks. It was getting tough for me. I came out in good physical condition and held the fear of getting probate again thinking the siege might be eleven months. I got another job. Stay Dry for about two months and off to the races again. I became terribly weak. Couldn't eat and try to get nourishment from booze and mostly only bootleg that one time. I just made it to a hospital and another time. A police patrol took me to the hospital. Instead of jail. I suffered badly from insomnia as many as three shots in the arm had no effect I would get in shape and back at it again. I was going to battle to finish. The time came when I was to be paid. My soldiers bonus I had the limit or maximum coming friends. Advise my folks to send me to a veteran's hospital before I got this money in my hands. I was pro baited again. Held in a county jail for two weeks and sent again to the asylum. This was my summer resort for three months. I was on the waiting list for the Veterans Hospital but I got into such wonderful physical condition from eating and working out of doors that I was released. I reached home full of resentment against my folks for their having my money tied up in a guardianship I went out and got saturated and landed in jail. I had been free from the asylum for about eight hours behind the bars again. So soon this was bad however I was freed again the next day and this was my last confinement with the
Telemedicine has come of age
"Telemedicine finally came of age this week. As Disneyland said it would close Broadway. Went dark so many conferences were cancelled and Tom. Hanks announced that he had tested positive. For the corona virus. Many people have the same questions like am I infected to? How do I find out at a press conference president? Donald Trump urged people to turn to telemedicine which I did as well this week after developing mild sore throat because as you know despite the many claims of testing becoming more widespread too cold reality is that as of today the local doctor. Office is unlikely to see you. I was directed by my doctor. Get my questions answered by the La County Health where the recording on the phone told me there were thirty people ahead of me on hold but the telemedicine folks are more than happy to take a look via. Webcam and figure out if you're actually at risk or not. Does it replace like real testing. No but it's a start as you can at least get an answer from somebody without having to wait for an appointment or worse visit in office that might be filled with people who are infected or you will in fact. I went on Dr Demand. Which is the website formed by Dr Phil and his son? J brilliant idea you spend. Your money is spent seventy five dollars. They claim that they'll work with your insurance. But I couldn't get it to work. You Click a button and you wait for a doctor to appear on the screen. I waited for thirty minutes But like it being in a waiting room I had other things to do because it was on my computer and I just walked away until Dr Susan Mayo came on the screen said hello to me. Check me out had be opened up my mouth. Basically put my mouth over the Webcam camera. So she and she had Even and she could look inside my mouth and see that. I wasn't swelling. She asked me about my medical history. She asked me about whether I had a fever and I had checked the fever before we made the call and she pretty much told me. What a doctor's office would say When I go to the doctor say to take two aspirin and get some sleep. She said stay at home and stay away from people which is basically what everybody's saying but the good news was she said. I probably didn't have the virus whether she knew it or not whether whether I would pass positive on test who knows but it was a bit I start. At least there was someone to talk to You couldn't get that far. You know there is talk about these drive through testing facilities At the press conference trump announced the Google was starting a website on Sunday to prescreen people. And that's just not true It's not google. It's a sister company to Google. And they say they are slowly developing it and they will. They will roll it out eventually. I don't think it's going to be next week. And I don't think it's GONNA be next month. So meanwhile what of the telemedicine? I spoke to a doctor in Boston. Named Dr Michael Klein who worries that we will become so comfortable with telemedicine. We'll stop going in basically because we don't have to take half a day off we don't have to drive over there. We don't have to sit in the office and wait for him. We don't have to take our clothes off. We just talk into the Webcam and supposedly get an answer. He says there's nothing like an in person visit for him to really see what's going on with you and a lot of nuances going on. He gets a lot of clues from the way you talk the way you act I'm probably with them. I I know that it's going to be more efficient. But Gosh I want to click that button and just get it over with don't you?
Author Roth weighed in on 'Plot Against America' before TV series was adapted
"This is fresh AIR let's get back to Terry's two thousand four interview with Philip Roth his book the plot against America is the basis of a new HBO mini series that starts Monday the novel has been adapted by David Simon and ed burns who worked together on the wire Roth died in twenty eighteen no no president Limburg in your novel may be anti semitic but after he's elected he knows better than to just come out and say at any initiate a program that brings young Jewish children to the quote heartland to kind of initiate them in the ways of heartland American life he initiates a homeland program that relocates Jewish families to get a quote heart heartland places of America and nobody really knows the Jewish families don't really know whether this is really meant to be a way of opening up their horizons are broadening their lives or whether it's a truly anti semitic way of removing them from safe friendly neighborhoods and putting them in in communities that might be very hostile and it also kind of breaking up the Jewish vote by breaking up a Jewish communities did you imagine that for Lindberg to really catch on in America he would have to use euphemistic language for anything that might truly be anti semitic at heart and helps in the language of the you know the heartland and just folks in mmhm mmhm you know well they are it is ambiguous to know what the intention is of for instance to begin with the first one which is called just folks that is a program in which Jewish boys from I think ten to fifteen for remember correctly volunteer if they want to to spend eight weeks in the summer on a farm somewhere my brother goes to Kentucky networks and tobacco farm they can go to any any place that's available where they can do farm work and work they ordinarily wouldn't do what's wrong with that why is it mostly Jews and that's what makes people nervous put it on the face of it there's nothing wrong with it now we move on to the next program which is called homestead forty to nineteen forty two as opposed to homes at eighteen forty two which was the original homestead act that is something else according to that piece of legislation large corporations are encouraged to transfer their Jewish employees to offices in more remote parts of the country and in the face of this legislation my father whose company is going to move us to Kentucky quits his job our lives in a way that is more because that is what there's more coercive that is I would say a bit more ominous and may be Lindbergh handy shown a little more strongly on the other hand if that's all this guy does it's not too terrible you know the limber disappears from my book before you can do anymore so you never really know what he's up to and again that's what I wanted I you never really know what he's up to he's a kind of jam heroic statue who looms over the book after after limber disappears then all hell breaks loose but I don't remember nobody can even in that that homestead act you know that in which corporations relocate Jewish employees the letter that your father gets home in the novel is so euphemistically just read a few lines from it you know if you're calling in life is proud to be among the very first group of major American corporations and financial institutions selected to participate in the new homestead program which is designed to give emerging American families a once in a lifetime opportunity to move their house sold at government expense in order to strike roots in an inspiring region of America previously inaccessible to them well doesn't that sound great but you know as the family in the novel figures out this is this is the the government and the corporation joining hands to to coerce Jewish families to move it was great fun writing that letter yeah yeah you really got that cheerful corporate PR results down found out what it was like to be Dick Cheney yeah I it's it's it's it imagine most people would not I would be impenetrable they would just take it at face value my father because he's so committed again against liberty from the start refuses to to do with aspirin Philip's cousin you know your cousin Alvin in the book get who who is something of a hood Hey Taylor and wants to fight against him and you know the United States under Lindberg is not going to join the war but he wants to wants to enter it anyway so he joins the Canadian Army and fights against Hitler but he loses half of one leg in the war and returns with a stump that's covered in ulcers boils and scabs he moves in with the Roth family and a first it's horrifying to fill up he says it was bad enough that we weren't living in a normal country now we would never again be living in a normal house a life of even more suffering was taking shape around me any praise to the housekeeping guides to protect our humble five rooms and all they contain from the vengeful fury of the missing leg in thinking about the impact that this missing leg this stump would have on the young Philip Roth's life did you have anything like it anything comparable to draw on from your own life no I didn't I didn't I I had to think my way through it I think the only thing that comes close lineages I never had as a child when I was in the army and I guess I was in my early twenties I was in the public information officer will treat hospital in Washington and my job was to go out into the wards and get information about US soldiers newly arrived who were injured or hurt or whatever and then write a little press release for the hometown paper and they had a lot of amputees at Walter Reed may be able to reverse the center I don't remember but they had many entities and so I went out on the wards and and I talked to these guys it was a sad as you can imagine is just after the Korean War or I go down to P. T. within physical therapy and watch them learning to walk on the parallel bars and so and so I sold my shares of stumps and not just of legs and the pathos was overwhelming overwhelming and so I carried this with me I think into the block and I think it's why it maybe even when I came to me that in fact I haven't thought of it till till now but I think perhaps that those experiences had a lot to do with determining how often would be would be wounded author Philip Roth speaking to Terry gross in two thousand for his alternative history novel the plot against America was published that year he died in twenty eighteen a mini series based on the novel begins Monday on HBO adapted by David Simon and
Tips To Prepare For The Coronavirus
"Are we got some really great questions from listeners? And I want to start with this one from Mattie Park in Ventura California okay. I'm just wondering how many people who get the corona virus actually die. How dangerous is it? Really? How much more likely is it to lead to death than the regular flu? You know. I'm afraid we might be whipping up some hysteria about this disease. Well I would say that. The good news is that so far. Most of the illnesses have been mild in China. Eighty percent of the cases have been classified as mild. This needs symptoms such as you know a dry cough may be a low grade fever something similar to a cold or perhaps the flu now. The death rate is estimated to be about two percent and this is really important to point out. It means that ninety eight percent of people who get this. Don't die from the virus right. Mattie asks how this compares to flu well the answer is that flu has a mortality rate of about point one percent or about one thousand. But here's something to keep in mind. Also that I think is really important. This two percent estimate is really provisional. It could be off. I mean early in an outbreak the sickest people are identified and there may be people with more mild cases have not been accounted for so that could throw off the calculation and it's possible that the death rate is even lower mean here in the. Us There are only a small number of cases but so far there have been no deaths and the people who do die in China tend to be older. The average age is in the seventies and the thought really is the people who are already in poor health due to medical conditions or habits such as smoking. The day are most vulnerable are their symptoms. That people should be on the lookout for and how are people who are sick actually treated sure well? Early symptoms include fever dry cough. Some people experience fatigue headaches less frequently. There's diarrhea the treatment is typically what healthcare professionals would call supportive care and that really just means giving medicines to keep a fever down making sure the person stays hydrated so plenty of fluids now shortness of breath can develop and that would be assigned. You need medical attention in a clinical setting. They can use a breathing machine to assist with breathing now. There was something that a bunch of people wrote in saying that they were confused about and that was something that Nancy Messina of the. Cdc said yesterday Yes we are asking the American public to work with us to prepare it in the expectation that this could be bad okay. One listener heard that in wrote to us. What does that mean exactly? It's completely unhelpful. Bottom line is what do we do in a practical sense? I completely get that. I think big picture here. There is no cause for panic right now but now is the time to prepare as we just heard the. Cdc says it's a longer question if if it's now when now we won't see outbreaks everywhere all at once in this country it could be cluster in a small town or maybe in the middle of an urban area. We don't know but think about this the way you think about preparing for snow storm or a Hurricane. It may not come. It may not happen but if it does you'd be smart to prepare. You may want to have some extra food in your cupboards have basic medications such as Aspirin Ibuprofen on hand. I spoke to Rebecca cats. She's director of the Center for Global Health Science and security at Georgetown University in this situation. If you have widespread virus in your community you may not want to go to a public drugstore. You may want to figure out ways you can distance yourself from other people. You also may want to think about what you do if your kids schools are closed. What is your daycare backup? Plan talk to your employers about working from home. Think through the details of that. It's really just about good
The Basque Carnivals
"Let's start with a look at the Mardi Gras and Carnival celebrations going on in Basque country. The customs and street parties will vary from town to town one of the oldest cultures in Europe. The Basques include some interesting public festivities in the days leading up to the fasting period of length traditions. That sometimes go back further than anyone can remember for a peek at how they do carnival in Basque country. We're joined by Claire Noah. She's from Hess Barron in the French Basque country and a Gustin lives in San Sebastian. On the Spanish side of the border. Welcome Claire and Augustine. Thank you very much so first of all. You're both from best country. Claire who are the Basques just very briefly and the basket is one of the oldest civilization in Europe and we are divided on those two parts one in France in another Barton Spain and Augustine. Those the language of Basque people yes. We speak Basque language which we call Skater. Who Scatter I WANNA talk about. Carnival carnival basically is the blow out before lent that leads up to Holy Week and Easter. It goes way back to even pre Christian Times on trying to get through the winter and there's a hope for resurrection for new crops in the fields for the end of the hunger time and the darkest depths of winter. I think the meat was going to go bad. And they had to eat it. All or something or carnival. Carney is the word meat and that led up to forty days of denial lent and then Easter so we know Mardi Gras in New Orleans. That's basically fat Tuesday in French. And IT'S CARNIVAL TIME RIGHT. Turn tell me about carnival. Because it's a big deal in Basque country. A Gustin what is carnival in your perspective. As a person in Basque country we have to waste of Celebrating carnival the more more than Christian celebrations. There are more popular on the Spanish side on the more traditional Pagan celebrations. That you can find in the past country of France. The difference is the recent history. I mean this pagan celebrations were banned by the dictator Franco for thirty five years He banned the use of the language and all kind of Celebrations related to pass or and this was banned. Sue was probably lost the in that time. So let me get this straight. You've got Basque culture. Which is a lot of ways? The same in France and in Spain but carnival is a mix of Christian and pagan traditions. And when you see these crazy creatures jumping up and down in Europe in many cultures it's pre Christian and it's a way to integrate the the indigenous religion in ancient times with the Christian. The newer religion and Franco was allied very carefully with the Catholic Church in Spain. He didn't want any pagan influence in the Spanish Basque country so he said this is a Christian festival none of that Pagan stuff but in France they were more free to have let loose with the pagan craziness. Correct correct Franco considered himself the highest representation of the Catholic Church and turn the country into a religious state Now clear I would imagine in France. Then you have some pretty wild costumes when people dress up during carnival especially where the Pagans go crazy in the French side of the border. What is the carnival? Can you just were on radio but paint a picture for look like for me? It's colorful with many natural things so we will have flowers leaves and we will have ribbons. We will have a chilling chuck which is a small bells everywhere. So you have to hear the carnival and you have to say it's an explosion. Okay of joy. It's just a moment where you go out from last year and everything that went wrong and you wish something really good for the next one so you just have to explodes yourself and just let it go. Go out with your animal part of you. Let your animal free and you're inside and we all have this side in so we have just. This is the perfect moment just to and then you start again so you dress up. There's music there's staying up all night. What's going on in different places? You've got different carnivals into French part of the Basque country three provinces for example Nepali which is really famous. You've got cash Celtic. So those people are going from house to house every weekend before carnival low even after they go to each house. They had get to know the neighborhood. So it's kind of ritual and they'll go to every house they sing. They play music. They DANCE. They share several cups of wine. And then it's a big party the tired but it's it's really nice. This is so interesting because I've been going to the best country for a long time and I have to be honest. I feel there's more character and enthusiasm in Spain because the French Basques are more French to me. More controlled by Peres but here on carnival. You let that ask animal that when you hear Claire. Talking about that from the Spanish Basque side on Carnival do you relate to have an animal you're gonNA lose all And fortunately now we have just a couple of little towns in the north of Navarro which are having the celebration in which the these men are carrying big belts that are bouncing and making big noise. Dig Like cowbells accounting. Yes huge cultures. A lot of this You know animal caretaking in the Malki. As the purpose of it is to wake the nature awake. The youth. Springtime is communist very much related to the end of winter. Welcome in the New Year and also we can in the nature and the spring is coming. So he's very much really. That's something you can see in two different towns in the north of Pamplona Navarre and also a couple of towns in the area outside San Sebastian. When I think of eastern Spain anyways I think of processions solemn processions like in savvy and so on some Amazon Too Holy Week Carnival feels a little more. Just apart and in. Holy Week is more sacred. Yes especially in the spiny side. You'RE GONNA see is big. Parades like you'd like him to turn off taller than most popular. One people go from all the areas. Go and see this parade. Our guest from Basque country are Agustin Cerita from San Sebastian Spain and Claire. Moya from aspirin a little town outside zone in the southwest corner of France.
"aspirin" Discussed on Stuff You Missed in History Class
"Hello and welcome. Welcome to the PODCAST. I'm holly FRY and I'm Tracy Wilson and this is our Our what we're starting to refer to as casual Friday. Yeah our little Our little chat Yeah so I. We're GONNA talk about the invention of aspirin because I did not realize I had long heard the stories of willow bark being chewed chewed on by people in ancient times as a treatment for various maladies but I didn't realize One I Edward Leigh. I am not a chemist in my high school chemistry experience was Shall we say less than installer. The teacher was amazing but I really struggled with it and so like I think she kind of just kept like passing me along just out of kindness. Because she's like how he's never going to get excuse and she was amazing and my all of my best friends were really smart at it so I felt like just the stupidest person on earth but I I did not really understand that. Saxon and salicylic acid are two different things because in a lot of casual literature that is not like a peer reviewed scientific scientic journal thing. They get used completely interchangeably. Dah well and the thing that our listeners will not know because they will have all been removed from what we recorded I incorrectly call it sal. Silicon every time I needed to say the word and I had to see what we always run into words like that for both of us I feel like I. I think it's just probably a word that got in my head wrong at some point and sort of stuck there. Yeah I also. I was watching several chemistry videos Trying to kind of wrap my brain around it with mixed success and I kept marveling because sometimes the way that that chemists pronounce things are very different from the way I ever learned them and then I think probably these words are said so infrequently by the general public that nobody really we get to wadded up about Pronuncia since most of that work is happening on paper and is being documented rather than just just orally Shared by like in the scientific community. They probably don't get as as weird about it yet. Somehow that reminds me I was. I was taking some transit transit the other day and I'm not going to name any names because I don't WanNa throw any brands under the bus But there was just a billboard with a picture of the product and the name of the the product underneath it and then underneath that said it's pronounced and then a rendering over pronunciation that did not look like how you would say that and I was career why you got a name your product. Something that requires an explanation for how to pronounce. It is not intuitive based on how you spelled it I would so love to fly on the wall in that marketing discussion. Yeah we're you know there are some executive way up the food chain. That Lake just decided with the name and then they're all like well. How do we communicate this? We make it part of our brand Dan. He's eventually we. We're going to have to give a phonetic spelling and when when we were talking about where the name aspirin came from and how the other letters correlated with things and this the ending of I n being popular at the time I made me just sort of dwell in in my mind for a moment about like pharmaceutical naming today and how just bizarre and random some of it can seem like it. It does not like a lot of the things when when you're watching TV and you're seeing the ads for for drugs. Sometimes it's like did you just put letters into a hopper. pull him out. Wanted US out of this work I did. I didn't end up using it as a source but I did while working on this episode stumble across essentially like an article that was written and by I think it was two experts on drug naming in a lot of it was about like trying to separate yours from others and how sometimes that means means that you have to do some things that are counterintuitive. Is this how we get crazy medicine. It's like people are just trying to be different. I feel like this Reminds me this is a big leap but come with me of wedding dresses in the nineteen eighties where everyone wanted to wear white but also wanted to look very different so so some very crazy design started happening. I feel like it's kind of the same thing everybody wants to sound. Scientific reliable you know comes from a place of great knowledge but also different enough. And that's how you get. Some of the nutty brand names that we have for drugs is my guess. Some of them are pretty pretty far field. Yeah I'm certainly very grateful that we figured out this whole aspirin. I also didn't realize that like to make it more palatable palatable and there are still people we should be clear that even in its its most easily digestible form still can have trouble With their their their GI tract from it. And from anything you know different. People are going to be sensitive to different things. But I didn't realize that your body is like doing such a big lift in terms of converting it and from the stable thing that you could digest to the thing that actually delivers pain relief gay. Yeah I'm learning. I'm learning nope which is always the ideal so our second episode this week coming out on Christmas Day was on the raccoon churches in Ethiopia. The complex called called LALIBELA. And I said this is the end of the show but I want to say it again as I was working on this there were times that I thought I wish this were a video podcast which I don't really wish because because that is so much more labor involved than the podcast we currently have but man. It's hard to convey how amazing those churches ages were without looking at them. I say were there exists Yeah they're spectacularly beautiful and just Brain breaking in terms of like how they were built it in some of the pictures that you will see you will see folks sort of clustered around the edge of the rim of the trench that circles the churches just with their feet dangling over and I look at it and I'm like man I am terrified at the at the idea because when I was a kid I was really scared of heights and that was something that I was able to move through in my young adult. Don't years but still occasionally if I'm in a high place I get a little anxious about it and just seeing sort of the the people some of whom had come on pilgrimage to just sitting getting around the edge of this four story deep rock. Trench was I guess both inspiring and terrified. I can understand that I think I'm more freaked out by the people standing around it. If they're sitting I feel well. I think I would be able to sit there but I would not be able to stand and lean over and look down without panicking and probably causing my own fall. Yeah yeah sitting great though. Somehow that reminds me of when I was eight I was a youth. I don't remember exactly how old I was. But it was. When Halley's comet came through and my church that I was raised in Organized a little trip up to a local mountain top to look at the comet and and this kid who was about a year older than me was so anxious about the other kids who were Kinda up there playing because there were younger kids also and there there was a a hang gliding ramp and they're hanging around the edge of the ramp and he was just so terrified that he was about to witness a tragedy agitating so yet the other thing. That really struck me. When I was doing research about this was how aw colorful and vibrant this stories that were part of it? That are part of the Ethiopian Orthodox religious tradition. I really loved the imagery. Injury of of King Lalibela being surrounded by bees. Yeah and I also really loved the Whole Story About Mental Act the first go into visit Salomon Salomon and coming away with the Ark of the covenant. I kind of want to go see if I can find more accounts of how that might have gone down because because one of the things that I was listening to about it kind of described it as like that he was either given it or he just sort of removed it the intensive that being a little less clear and then as you said it It also reminded me of Indiana Jones as I I was working on that. Yeah don't Don't open that ARC. That's what I know. Yeah well it's treated in an incredibly sacred way All the ARCS are the story. Is that when the Ark of the Covenant was returned. It's been guarded by just one. Monk and a lot of the REPLICA ARCS. That are in the lally Bella Complex are similarly like they're in a part of the monastery only one person or a very select. Few people are even allowed into the area where it is kept so you can look at the UNESCO website for example they have lots and lots of pictures of what these churches look like. Stuffy missed in history classes the production of iheartradio's. How stuff works for more podcasts? For my heart radio. visit the iheartradio you Apple Apple podcasts. Or wherever you listen to your favorite shows. I'm Zoey Deutch. I'm Amanda CEO's Hey there I'm Bellamy let me young and today I'm GonNa talk about what I wore when I- auditions for scandal. Welcome to what I wear when production of Glamour and iheartradio. I'm your host Perry sabotaging each week. I'm sitting down with a woman. I find fascinating to talk about what she wore during a pivotal moment in her life. Listen to what I win on the iheartradio APP apple podcasts. Or wherever you get your podcasts..
"aspirin" Discussed on Stuff You Missed in History Class
"The all new two thousand twenty Ford Explorer. Tracy I know that you have been thinking about an interesting thing lately. Which is what your pick would be for the greatest exploration vehicle GEICO of all time? Yeah I'M GONNA go with. The research vessel petrol that was owned by the late Paul Allen found so many shipwrecks which our listeners love that we started to make jokes about it and this shipwreck. That wasn't found by that vessels. Well The all new two thousand twenty. Four explorer is the greatest exploration vehicle of all time time there are a lot of places that have been explored by other vehicles but this vehicle the Ford explorer is going to take you to places that you might not think of as explorations but really really can be for example. Maybe you navigate your life and you have to get around town which can be a whole big problem especially if you live in a city like Atlanta. We're traffic tends to be congested rested. Sometimes you just want to go on a great vacation and riding in a perfect vehicle makes it the ideal ride or even just mundane things like going to the grocery store. Sometimes that is a true feet to achieve. If you buy groceries the way I do you can do all of this. And more with the all new twenty twenty Ford Explorer. That's the all new. Are you twenty two thousand Ford Explorer. The greatest exploration vehicle of all time The German patent.
"aspirin" Discussed on BrainStuff
"Combining their industry expertise with the open source leadership of Red Hat. Let's unlock the world's potential essential. Let's put smart to work learn more at IBM dot. com slash red hat welcome to brainstorm a production of iheartmedia. Hey rain stuff lauren vocab here the average headache backache often sends people reaching Willy Nilly for the nearest bottle of over over the counter pain reliever but for best results. It's smart to match the particular problem with the particular pill. That's because the wide variety of pain relievers known in medical circles as analgesics available today are each effective at different problems and come with different risks. There are two categories of pain pills suitable for home use this non steroidal anti inflammatory drugs more commonly referred to as m saids end. Acetaminophen both are considered anti redick's which means that they can can reduce fevers. Most people know Acetaminophen better by the popular brand name Tylenol but there are other brands as well like fever all the category Korea is broader things like aspirin ibuprofen and Naproxen all fall under the umbrella. There are others but these three are some of the most widely used each each has its own range of brand name versions so which one is best to use it all depends on what you're taking it for Acetaminophen often sold under the brand name Tylenol was approved by the US Food and Drug Administration in Nineteen fifty one but how it works still not clearly understood but we do know a bit about what it does we spoke by email pharmacist Terry Thompson Dr Pharmacy and VP of Clinical Services at innovation compounding. She said Acetaminophen does not decrease inflammation but works in the hypothetical to reduce fever and it may work peripherally to block the generation of pain. It's best taken to reduce news fever or symptoms of pain from flu like illnesses headaches arthritis and menstrual cramps but note it will only mask the pain without treating any underlying inflammation inflammation problems that caused some of these symptoms. You should not take acetaminophen while consuming alcohol it can be hard on the liver. Even when you're stone cold sober and much much worse when consuming alcohol most serious liver problems have been reported following large doses the highest amounts considered safe is three thousand two hundred and fifty milligrams per per day or ten regular strength tablets however there have been instances when liver damage occurs after medicating with moderate or even small doses over a long period of time cinnamon offense should be taken carefully in conjunction with other medications as many headache and cold meds like Nyquil already has been in them. This can lead to accidental overdoses anyone taking one of these extras should carefully read labels follow dosing instructions to the letter. It's considered safe enough to take by just about anyone anyone but occasionally side effects are experienced most often those are nausea rash and headache which is pretty ironic considering that that's why many people take it in the first place is so that's CNN now. Let's talk about these are sold under brand names like Bayer advil Motrin and leave you know how often doesn't do a darn thing to reduce inflammation well and sets pick up that dropped ball and run all the way into the end zone with it short for non steroidal title. Anti inflammatory drugs the category of end says include a variety of analgesics like aspirin one brand name being bear ibuprofen such as advil Motrin and Naproxen oxen like aleve although there's some variation by particular type and says in general work by blocking the production of chemicals called prostaglandins which encouraged fever a pain and inflammation these effects can be useful in promoting blood flow to an injured area end in telling you to watch out and not further hurt and injured area but there's is a point which it's like dude body. I know I shouldn't walk on that foot. You can stop telling me so hard and said go out of their way to denote non-steroidal in the the name because steroids can also reduce inflammation but the way steroids work by depressing me. Immune system is a major distinction. So when did you take 'em Ed's Thompson said those with inflammatory conditions such as osteoarthritis rheumatoid arthritis menstrual pain or muscular pain would benefit from an end said the proximate intends to work longer in the body about two times longer so those with gout or more chronic pain conditions may see more pain relief from using naproxen verses ibuprofen however ibuprofen provides quicker pain relief than naproxen end is less likely to cause an upset stomach so might be more appropriate for strong and sudden pain have hangover skip these Dominican in favor of An said although nothing short of time rest and lots of hydration can completely cure a hangover the anti inflammatory Tori properties that end says boast are believed to be helpful however taking an end set on an upset stomach so common with hangovers can make the discomfort worse so don't take it on an empty stomach will ever but especially in the case of hangovers aspirin has long been used as a daily supplement of sorts for people at risk of heart attack and stroke because it inhibits potentially tragic blood clotting for roughly four to seven days one important caveat however is that people consuming aspirin for that purpose should should use a lower dosage under three hundred and twenty five milligrams per day than those using it for pain relief purposes. Thompson says that aspirin is more commonly used nowadays for inhibiting opening blood clotting then for relieving pain due to intestinal bleeding risks which brings us to when not to take them women who are pregnant or trying to become come pregnant are typically advised to avoid use of because they're believed to cause fertility issues early miscarriage and even birth defects in particular they should not be taken in the third trimester trimester because they could cause premature closure of a particular blood vessel in a developing baby people with gastrointestinal problems might also steer clear of and said use negative active gastrointestinal side effects like ulcers or intestinal bleeding can occur because as we said Prostaglandins aren't all bad prostaglandins protect the stomach lining and help with blood-clotting when those functions are inhibited the risk of bleeding and ulcers goes way up. Thompson said although this is more likely in those who take large doses for for long periods of time patients often turn to a seat from leads for pain relief since it does not cause intestinal issues still confused about which to take the talk to your doctor or the pharmacist local pharmacy. They'll be able to make a recommendation and point you towards the correct product..
"aspirin" Discussed on This Podcast Will Kill You
"But this was a really interesting dive, and it get made my job so much cooler, this time around than to just say, yeah. They don't wanna get eaten. But the, the amazing thing is, I'd always associated with willa. Like I said it was one of the first times, I learn about, like, what was going on with plant chemistry and how that's been co-opted by humans. And you mentioned the bitter taste and I have a really funny pictures of my friend, Steve chewing on willow branches after we learn this just making an awful face, but it's found in different levels in a wide variety of plant species. This is something that plants are dealing with quite a bit. And it might have something to do with the, the defense response, and some of the regulatory functions. But the levels is what's most interesting is they found upwards of a hundred fold difference in what's produced not only among organs within plants, but among different plants. I don't know. I tried really hard to figure out why willow especially could have just been that we are closely associated with willows. They have deep historical ties to our society and our cultures or just could be that they're producing a lot more of it. I don't know. So if anyone does. No, please let me know because I would really like to know that. But it has been recognized as sort of the signal mediating plant response to stresses, but also sort of a regulatory function from hormone standpoint. So it's, it's a fanatic compound. I do think that even though you get it as salads in plants will turn it into salicylic acid. I just don't know if that involves any sort of extraction, but from the defense side of things there's a lot of papers on this in, what's fascinating is what we know about. Salicylic acid implants is still largely up in the air. There's a lot of unknowns. But we know it from studying mostly economic important species. So tobacco comes up a lot in this research, as well as rabid ops, which is the model plant system for understanding like jeans and stuff like that. So it's, it's there it's an a lot of different things, but one of the main functions in defenses that it's regulating like local disease, resistance mechanisms, and also, like assist acquired resistance, or the essay, our response. And there's a lot of pathways involved in this, I'm only going to mention a few of them. But what ends up happening is that it helps recognize invading pathogen, and then it mounts effective defensive response, which is split between sort of this cognitive pathogen encoded effector protein, which is essentially unaffected tributed ineffective triggered immunity, which then leads into what they call a hyper sensitive response. And if you've ever seen a leaf that looks really blotchy with a lot of narcotic tissue on it. You're seeing the hypersensitive response in action. So a few plant heights. Yeah. Plant hives, but think about plants as sort of these compartmental organisms, they're not like us with a low. I mean they are connected, but they're modular, you can break off pieces in plants oftentimes with their immune response when isolated just by knocking out that entire section of their tissue. Just kill it off. It's gone, and there's evidence that it's this comes into play here. So after some sort of infection is detected a few hours after even. The unoccupied portions of the plant will also sort of start to take up increased levels of the genes that start this systematic acquired resistance python. So that's more of the long lasting thing. So there's both timeframes getting involved here in immediate response, where they start killing off and trying to localize it. And then okay, we have to protect the rest of the tissues, and this is were sell silica Gasset comes into play. Yeah. So the biggest evidence that we have for its role really comes from studying plants that are deficient in these genes ability to produce it. So it's the mutants that tell us really what's going on. But it's signaling component involved in this. And so it accumulates in high levels around the sites of infection, but then after a decent amount of time it varies from species to species, you'll see it starting to turn up an uninfected systemic tissues. So they have discovered that even by inoculating the plant, or applying it with aspirin, essentially, the powdered up put it in there in some form, they can actually get those genes to start playing a role and turn those on in the plant..
"aspirin" Discussed on This Podcast Will Kill You
"It's really. Very few things that I remember from, like, original BioChem in this is one of them because I think it is just so. So fascinating. Oh, I love it. So that's how it works. You have aspirin that binds irreversibly to Cox, it blocks the activation of platelets. It does. So for the whole life of that platelet, if you don't have activated platelets, you don't have clot formation. If you don't have clot formation. You don't ACLU your arteries, if you don't include your arteries. You don't have a heart attack bloom. Simple one two, three four. I don't know how many steps there were there was a lot. I understood it matters a lot for any medical texter. Yeah. So I've been pro Finn which is another and said, it's another non-steroidal anti-inflammatory it works very similarly. But again, it is reversible. So it's not gonna have that same long lasting effects Tylenol, or acetaminophen or paracetamol as a millionaire. Is not quite the same it actually it's not entirely clear, yet, how Tylenol really works. We think that it binds Cox. But it does not do so in your peripheral body, but it might do so in your brain. So Tylenol isn't technically an anti inflammatory. It does not have anti inflammatory properties. It does have analgesic properties. So it will it will reduce pain, because it works on your nervous system, and it will reduce fever. So it's what we call an anti Rettig. Okay. So really quickly I guess we can just talk about. Like when you would actually use aspirin. I don't know. Do you wanna talk about that? Yeah. So, like I said, there is some evidence that for certain populations aspirin in small doses can be used to lower the risk of future, a myocardial, infarction, or heart disease. There's also some evidence that it can be effective in lowering the risk of some cancers, especially colorectal cancer. And this has to do not so much with its effects on clotting and throw boxing's, but on its inflammatory anti inflammatory effects because number of cancers processes were sort of learning this more and more are associated with prolonged inflammation. So if you think of something like something, like all sort of colitis which is a very high risk for colorectal cancer is an infla-. Matori bowel disease, singing, have constant inflammation in the colon and that puts you at risk for developing cancer. If you can reduce the inflammation, you can potentially reduce the risk of cancer. That's the thought. So does that go back to what you had told me a couple of weekends back, where anytime you get a situation where sales are constantly being asked to replenish themselves. You always run the risk of irregularities in cell division in this cancer. Exactly. Mind blown. Now, I also want to say I'm gonna give you two disclaimers. Number one, baby. Aspirin is called baby aspirin because it's eighty one milligrams of dose, rather than three hundred twenty five which is like grown have aspirin regular aspirin like aspirin. You take a headache. The adult aspirin. It does not mean that you should give baby aspirin to baby. Because. Bad naming. It's a terrible name for some reason, and it's not clear. Why this happens if you give aspirin to children under basically under teenagers? It can cause a very, very serious disease called Raya syndrome, which you mentioned Erin, which can lead to encephalopathy, which is swelling of in brain liver, failure, and death. It's not clear. Why this happens? But that's why in general, the recommendation is never ever give children aspirin, if they have a fever, you give them, Tylenol or maybe Motrin, which is proven. Oh, so thought explains the Tylenol okay that my childhood makes a little bit more. My mom was listening. Don't give babies aspirin. Thanks, mom. And the other caveat that I want to make is that the evidence of the effectiveness of long-term aspirin treatments is still quite mixed. It's not clear that every single human is gonna benefit, and it is absolutely not the recommendation that every adult needs to be taking baby. Aspirin, so to be clear. I am not yet a doctor who can make those kinds of recommendations. So I am not suggesting that everyone go out and start taking a baby aspirin..
"aspirin" Discussed on This Podcast Will Kill You
"They went back through their development records and found a chemical by the name of n acetyl para a minute, phenyle, which appeared to be an analgesic. But with some nasty side effects so they revisited as chemical, which they called a CD benefit. Oh, yeah. And didn't find any of the side effects that it had that had halted its earlier development. Boom new drug created perfect done. I had no idea that they are also made Tylenol they call it Panadol. So this was they called it acetaminophen. And then in the UK it became known as paracetamol and it. It's brand name was Panadol. And so it was like it's flew off the shelves because this was this non stomach irritating aspirin alternative and aspirin kind of just started to slip out of the leading place in the market. And in the US say Dominican, of course, would be Tylenol, and I pro- Finn was not far behind. And so, by the nineteen sixties, the trio of aspirin acetaminophen slash paracetamol an IB pro fin dominated the over the counter analgesic market and aspirin continued to slip until the nineteen eighties. And it took a major blow when the link between aspirin and raise syndrome was discovered. So just when things were looking pretty grim for aspirin its renaissance would begin. Who all of this history of aspirin that I've talked about so far? There's a lot of history there. Sorry about that. Its mechanism of action was still unknown, though a new how it works. Yeah. It's funny because there wasn't much interest in finding out the mechanism of action and till nineteen Fifty-eight when a dude, a chemist name, Henry Collier, decided to play around with it, and over the next decade or so Collier, along with pharmacologists Priscilla piper in John vane. They worked together sometimes separately, sometimes on the same project to uncover the mysteries of aspirin, and I'm not gonna go into the whole thing. But essentially, what happened is that John vane made the final leap, and he and piper would publish the results in nature, where it became one of the most cited papers of all time, Cuong, vein one, a noble or was awarded a Nobel prize for his work, pharmacology understanding, the three main effects of aspirin, so pain reduction. Inflammation reduction, and reducing the ability of, of blood to clot did more than just solve a scientific mystery. It also held huge implications for the uses of aspirin, one of these being that in small doses. Aspirin had this affect on the bodies causing ability. So in the second half of the twentieth century, and through today, of course, heart disease is a leading cause of death in many industrialized countries such as the US in parts of Europe. And this anti Cottingham ability of aspirin also meant it could be used as a possible, heart attack preventative and despite many successful trials. This idea was slow to gain traction, but by the mid nineteen eighties, it was finally accepted, which meant new branding and campaigning. In the marketers back to the whole aspirin advertising situation..
"aspirin" Discussed on This Podcast Will Kill You
"A law was passed restricting promotion of a patent drug just the name of the company and the name of the drug. That's it. You could just say this is the name of the company. This is the name of the drug. See can't say like what it does or. Nope. Not at the time weird to stink and only non trademark drugs called by their generic names could be included in the in the official US pharmacopoeia. Oh, yeah. That's still like we only learned non-trade names, this, what's on the, the US, Emily tests, and everything, wouldn't make sense. Yeah. Yeah. All of this trademark patent advertising controversy is going down in the early nineteen hundreds and guess what happens in nineteen fourteen. Titanic note. Twelve I actually knew that the defenestration of Prague, God the dust bowl. Went once the dust bowl actually reading. Grapes of wrath. Okay. All right. Well, World War. One is what happens. And so, with this outbreak of war, citizens of the UK or like we're not supporting fair is a German company. But that was easier said than done first off large scale manufacturing of CDL sell silk acid was logistically difficult and many chemical companies had switched to making wartime things. Explosives poisons whatever. And doctors were still prescribing aspirin capital a rather than seato sell silk acid. So buyer was still making a killing, and they also were making mustard gas. So they were also making a chemical that was doing killing. Yeah. It's a sideline as we've learned. So. Yeah. So bear with so making a killing, but that was only until the British government board of trade nullified, the trademark on aspirins name, and it made it public property. Yeah. Because now it's just Aspen lower case. Yes, I never put together there. Yeah. Okay. Maybe you'll remember some other things that happened during Woodward one that are relevant to the podcast like the nineteen eighteen flu. For example. Yes. Precisely get one. Even though early rumors went around saying that Bayer made aspirin was actually responsible for spreading the flu because it was a German company. Right. But soon people got over that and were popping pills, like crazy, which, actually recent studies suggest may have actually led to excess death due to influenza, particularly in those age groups that were the hardest hit is really interesting paper on that. Yeah. So after World War One though the aspirin market became a free for all and tons of different companies.
"aspirin" Discussed on 850 WFTL
"Come on. Go. So. Hey. Oh. Draw? That's pretty good. That's up there. Saghir? What? That was quality. Did he know joy clearly? Your own. The pay. Higher. Stop by. Zone as. Failed the test. Joy. Okay. Aspirin depends what he.
"aspirin" Discussed on Z104
"In. Siegen? Aspirin. Binion. Come back. Still.
"aspirin" Discussed on The Rich Roll Podcast
"Crucial aspects of our success equation so i can easily make the argument for example that my my perfectionist standard control issues that's how i was able to even get here to this place where i get to sit here and talk to you and if i let go of that that's very threatening that's terrifying right because that means that i have to come to this decision that that that that is in fact not what's feeling my success and just coming to that understanding is difficult and it would then put me in a place of confusion and mystery yet okay so what you're hitting on big time right it's almost like what would be a an easy example is that okay i have a headache and so the docker someone that i trust take aspirin you take aspirin for headaches i get a headache don't get to accept much action that like whatever it is right you take you take something for headache and it works like okay good okay and then at some point you say stomach ache you go into the doctor the stomach ache and let's a little test oh you've got some ol serves how often do you take the headache medicine why take it three times a day no no no you gotta stop doing this too much but it works i don't have headaches but now you have an ulcer so it's a little bit like this system that got you here and i see i see this all the system that got me to a certain phase of my life getting this phase of my life has worked but there's limitations and i see it with like world class athletes that say you know what got me here i've got two gold medals i've got this that and the other accolades but there's another space that i need to figure out because this is no longer working anymore and so it's like now the question is do you stop taking the medicine.
"aspirin" Discussed on WTRH
"To feel normal is kind of like if somebody goes out for it they have a matter of fact i explain this to a judge in a corpse seizure if somebody goes out and they have a drink you know to relax to socialize to have a better time i have no idea why people go out have a drink i said they do it in my mind lighten up a little bit relax well why wouldn't somebody with a mental illness to this you wanna talk about something that needs to lighten up and i'm not justifying it but we are finding more and more that this is what happens they self medicate and that's why are you know opiate use and all that is so high from this and it's important to understand drugs kind of drugs were talking about we're not talking about aspirin kinds of drugs that we're talking about they are all mood altering right they are so with alcohol there are certain characteristics some people will say well that just helps me numb out to learn about it's a depressant that's what the classification now what you have in regard to the drug of the we're talking about their their several types but with alcohol which are all would be depressants it's there years ago i learned that they shot of alcohol the killed millions a brain cells that the problem that you have is you love your son you care about your son you know he has a mental condition and you would like for him to be as sharpen his bright is he could possibly be to be the maximum that he could be is that correct okay good and and i know i just believe that about you the problem with if we're just gonna look at alcohol we're talking about impairing it it impairs the brain it doesn't help even though at the moment if someone were perhaps in a manic stage that's bipolar manic depressive so if someone.
"aspirin" Discussed on VIBES-LIVE
"This his knees any time of the sia aspirin the meeting next week mike gillislee wing miss follow on instagram at away what done that god the swoop on the butter predictive into a side so to speak out of shipping doping approach to financial data via took whether or not he could pull them despicable singapore them wunderlist total does picture skin lead me they told medieval you minutes could okay i'll say lippi those clincy came in with your brain coming you don't come guided missiles the owners may not have enough to assume that you'll make you donald mind there may be that you're such a united sevastopol pulled up quitting cgi tbi separately village brilliant young he's a few moments be the two people yup your acupuncture you'll massameh abajian intended about until we get away to give me a sequence endo dims your daily systems till you asked him to compete after that how does get when we in butter john the comply that you do nothing dental care financially to their seat in this until monday to from detained leonardo click undertaking literally give then paul told me be dampened me now.
"aspirin" Discussed on People's Pharmacy
"For such an event this works out to one unexpected cardiovascular complication per year for every 74 aspirin quitters aspirin can cause serious bleeding and even low dose aspirin can irritate the digestive tract people who were taking aspirin because of a previous heart attack had a higher rate of heart attacks stroke or death if they stopped in that situation as many as one in every thirty six of these patients suffered a cardiovascular complication the scientists urge policymakers defined simple measures that will encourage people to keep taking their low dose aspirin they point out that it is an inexpensive pill with substantial public health benefits you are traumatic medical records are boone widespread for more than a decade the respose to improve patient care make prescribing safer and allow patients to have their records with them where ever they need care this portability was supposed to improve efficiency lower costs and reduce medical errors for example if a patient has a scan and hospital ex but undergoes surgery 'em hospital why the scan along with the prior medical records should be available to the surgeon billions of dollars have been spent converting paper records to digital formats how well has the new system worked not as well as you might hope according to a new report based on data from the american hospital association less than a third of the hospitals surveyed were able to exchange electronc acc medical records with other institutions as a result patients and their families have had to take the initiative to access records and get them from one medical facility to another the bottom line seems to be that hospitals are not sharing information in a usable fashion the cost.
"aspirin" Discussed on Sawbones: A Marital Tour of Misguided Medicine
"I can't say that it prevents cancer yet but they found some studies that are intriguing so aspirin does do a lot of things um one thing i want to tell you not to do is please don't make a paste out of it and put it on your body uh that's that's the thing that we see periodically um i think it's like an old folk remedy and you crush up aspirin and kinda turned into a paste and put it wherever you're hurting or like if you have a fever or something they'll just put it on like the chest area that seems like a lot of yeah it's bad you'll absorb that you do absorb that please don't do that that's just something generally speaking we we always recommend against so just just to be aware at lake there are still alka seltzer is out there if you've heard of good he powder uh yeah people around here loved to take goodie powder for headaches that has aspirin and i think about that um it's the same thing is bc powder there's a lot of those things i've mentioned like buff x and buffering and i mean there at the at like a we've talked about the the gum that isn't around any more thank goodness um but there tons of different meds out there that contain aspirin that you may not be aware of so i would be very careful in general with over the counter pain relievers especially if you have a lot of complicated medical conditions or if you are on a lot of other medications or just you know it never hurts ask your doctor he which of these is probably the best thing for me to take if i have a headache or if i'm hurting or whatever permanent respite.
"aspirin" Discussed on Sawbones: A Marital Tour of Misguided Medicine
"To try to figure out all the things that can do is prove i remember seeing as like you should taylor's rather heart attack and yet he like my sharjah's now you shed is a headache pill that's the first thing we do if someone comes in and we think they're having a heart attack or stroke we give him an aspirin assery away as a quick surge was continued until two thousand it's incredibly arrogant i had a really you see it's a i will say it i think it's more well known now that generally we don't give kids aspirin yeah like i said unless there's a very specific reason that your kid has some condition that we have said take an aspirin generally do not give children aspirin period under nineteen i think is the recommendation swat officers though so it is used in the prevention of heart attack and stroke it does work for for pain and fever and those kinds of things but because it is this bloodthinner because it does this other thing it may not always be the best choice for that acetaminophen does not do that so for some patients may be safer if you're on certain medications or if you have other conditions um if you're already on kind of blood centers and that kind of thing aspirin could be very dangerous for you um it can cost things like bleeding ulcers as can things like ibuprofen so if you have a tendency for bleeding or that kind of thing again there's a lot of reasons why you might not just wanna willingly take an aspirin so it's it like i say with everything you should talk to your doctor but they've even found some studies that have correlated aspirin use with a reduction in cancer risk.
"aspirin" Discussed on Sawbones: A Marital Tour of Misguided Medicine
"Over islam now there's other alka seltzer it's at same thing alka seltzer has different you know products under alka seltzer tempting with annus and ask them was just aspirin caffeine and then it grew to a lot of other things surgeons aspirin having to hurry yet although i think sedrine has other formulation like there's other pro in a like tylenol has a million different products that had same idea but yes yes uh now all of this created like this aspirin fervor fever puberty the jerk that owns fever yet fanti pareto and i love grazing anyway and uh the only thing that dampened in the fifties in the say sees a couple drugs came in the market first of all acetaminophen which he probably knows tylenol was introduced and then shortly thereafter ibuprofen was introduced and both of these cut into aspirin sales majorly because some people found them to work better and for a variety of reasons sometimes they might have been safer especially tylenol for various patients um the other thing that really put a damper on aspirin sales was rise syndrome reis and drum eh did you ever here don't take aspirin if you have chickenpox have you ever heard that a lot of people may have kinda that they knew that but they didn't know why they knew that any 80s this rare complication was found in children who were given aspirin while they were recovering from certain vine viral illnesses chicken pox is the one that gets the most press but really was just any kind of viral illness they had a fever they feel bad they were given an aspirin and they developed this inflammation of the brain inflammation of the liver very serious illness that sometimes could have been fatal i'm just a small number of children but enough that they're grew this concern why is there this reaction in kids who get aspirin with certain viruses we all know but the point was be careful don't give aspirin to kids was what grew out of this concern period of his agenda box don't give aspirin to kids grew out of this over unless for a very specific reason you're doctors told you to give your kid aspirin don't give you could aspirin hooker is a good rule of thumb.
"aspirin" Discussed on Sawbones: A Marital Tour of Misguided Medicine
"Every every plant the contains that you got to wonder about its bioavailability like how much of it can you absorb based on how it is two thousand pecan comparison so i mean if you wanna eat two thousand peas i'm not going to stop you would stop me incorrect without without view immunity that peace are very small to be fair so you're saying review got jeffy ilk i never considered out ever considered veterinary mp's by the individual yuda as like how many figure out at you you're a guy do chicken to lose 50 ap's thought the and that doesn't sound like very many you say fifty ap's and i think that's probably a very small amount of fees at all hours never considered the amount of luxury hills also degrees over your very hard to calculate calorie gunter so so in all of these mentions of the use of these solicit late sal soak out senseless late amusing these words interchangeably containing plants it usually used for pain or for fevers that usually howitt's referenced as as being you know employed as a medicine aged chinese medicine also advised willow bark specifically for a variety of illnesses like i said pain and fevers also things like romantic fever specifically a goitre they recommended willow bark for a colds probably because of the a and pains and fevers and all those things that came with it and even bleeding which was probably a bad idea because as we're going to talk about aspirin does.