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"alexa teza catheter" Discussed on NEJM This Week - Audio Summaries

NEJM This Week - Audio Summaries

07:27 min | 1 year ago

"alexa teza catheter" Discussed on NEJM This Week - Audio Summaries

"H. E. Five Zero Eight D. E. L. minimal function. Gino Gino Types Alexa after Teza. Catheter Ivankov after relative to placebo resulted in a percentage of predicted Efi v one. That was thirteen eighteen. Point eight points higher at four weeks and fourteen point three points. Higher through twenty four weeks a rate of pulmonary exacerbations that that was sixty three percent lower respiratory domain score on the cystic fibrosis questionnaire. Revised that was twenty point. Two points higher and sweat sweat chloride concentration. That was forty one point eight million moles per liter lower Alexa Teza Catheter. Ivankov after was generally safe and had an acceptable side effect profile. Most patients had adverse events that were mild or moderate Alexa after Teza Catheter. Ivankov after was efficacious in patients with cystic fibrosis with P. H. E. Five Zero Eight D. E. L. minimal function Gino types in whom previous previous cf tr modulator regiments were ineffective in an editorial Francis Collins from the National Institutes of Health Bethesda. Maryland writes that the results of a pair of phase three clinical trials in the journal and in a simultaneous publication. In the Lancet document and impressive benefits from triple drug therapy for persons with cystic fibrosis. And at least one copy of the P. H. E. Five Zero Away D. E. L. CF tr mutation who represent approximately ninety percent of persons affected by this life-shortening autosomal recessive disease. The these findings indicate that it may soon be possible to offer safe and effective molecular targeted therapies. To ninety percent of persons with cystic fibrosis. This should be a cause for major celebration yet. We must not abandon the patients with cystic fibrosis. Who have known mutations -tations and will not have a response to these drugs even beyond that the best day ever for all of us traveling down? This long road together will be the day. When the more than seventy thousand persons with cystic fibrosis worldwide? Do not need to take drug therapy at all. And they're finally is a permanent cure for cystic fibrosis. That works for everyone. Although the challenges are substantial one can imagine such an ultimate approach approach involving in Vivo Somatic cell gene editing of Airway epithelial cells shortly after their identification of cf tr. Thirty a years ago Dr Collins wrote a song entitled Dare to Dream. The lyrics expressed hope that the gene discovery would lead to effective treatments for cystic fibrosis. That someday we would see all our brothers and sisters breathing free. Dr Collins writes that it is profoundly. Gratifying edifying to see that this dream is coming. True Five Year outcomes after PCI or cabbage for for left main coronary disease by Greg Stone from the ICAHN School of Medicine at Mount Sinai New York long term outcomes after perky cutaneous coronary intervention. PCI with contemporary drug alluding stance as compared with coronary artery bypass grafting cabbage in patients nations. With left main coronary artery. Disease are not clearly established in this. Study one thousand nine hundred five patients with left main coronary artery disease of low or intermediate anatomical complexity were randomly assigned to undergo either. PCI with ever Alma saluting stents or cabbage at five years a primary outcome event of death stroke or myocardial. Infarction had occurred in twenty eighty two percent of the patients in the P. C. I. Group and in Nineteen Point two percent of those in the cabbage group death from any cause occurred more frequently in the P. C. I. Group then in the cabbage group in thirteen percent versus nine point nine percent in the p. c. i. and cabbage groups the incidences of definite cardiovascular death five percent and four point five percent respectively and myocardial infarction ten point six percent and nine point one percent were not significantly different. All cerebrovascular events were less frequent after p. c. i. than after cabbage. Three point three three percent versus five point two percent although the incidence of stroke was not significantly different between the two groups two point nine percent and three point seven percent send ischemia driven re vascular. Ization was more frequent after PCI sixteen point nine percent versus ten percent in patients with with left main coronary artery disease. There was no significant difference between PC. I and cabbage with respect to the rate of the composite outcome of death. Stroke or myocardial infarction at five years prevention of early ventilator associated pneumonia after cardiac arrest by blue no hosoi from Johnny Mass Young polyvalent Limaj France patients treated with targeted temperature management thirty to thirty four degrees Celsius after cardiac arrest are at increased risk for early ventilator associated. Pneumonia this is trial involved. One hundred ninety four adult patients in intensive care units who were being mechanically ventilated after out of hospital. Cardiac arrest related the two initial shock. -able rhythm and treated with targeted temperature management at thirty two to thirty four degrees Celsius. Either Intravenous Amoxicillin Ceiling Clavier Linate or Placebo was administered three times a day for two days starting less than six hours after the cardiac arrest the incidents it inside of early ventilator associated. Pneumonia was lower with antibiotic prophylaxis than with Placebo. Nineteen percent of patients versus thirty. Thirty four percent no significant between group differences were observed for other key clinical variables such as ventilator free days and mortality at day. Twenty eight at day seven. No increase in resistant. Bacteria was identified serious adverse events did not differ significantly between the two groups. A two day course of antibiotic therapy with Amoxicillin Clavier Linate in patients receiving a thirty two to thirty four degrees Celsius Targeted temperature management strategy. After out of hospital cardiac arrest with initial shock -able rhythm resulted in a lower incidence of early aleve ventilator associated pneumonia than placebo acute severe hypertension a clinical practice article by Aldo Aldo. Push Oto from Yale School of Medicine New Haven Connecticut. Blood pressure elevations. Above one hundred eighty over one hundred ten to one one hundred twenty millimeters mercury can result in.