3 Burst results for "Akwa Lung Therapeutics"

"akwa lung therapeutics" Discussed on The Bio Report

The Bio Report

08:03 min | 1 year ago

"akwa lung therapeutics" Discussed on The Bio Report

"As a researcher Joe Garcia Applied Functional Genomics to understanding genes that contribute to inflammatory disorders such as acute respiratory distress syndrome or arts as founder and CEO of the Biotech Company. Akwa Lung Therapeutics. He's working to advanced therapies to hit these novel targets to treat unchecked inflammation with the company's lead experimental therapeutic candidate targeting arts. We spoke to Garcia about the company's arts. Therapy how it works. And why it's time we focus given the cove nineteen pandemic Joe. Thanks for joining us. To be here thing we're going to talk about Aqua Lung Therapeutics Acute Respiratory Distress Syndrome or arts and your efforts to develop a treatment for this condition. Let's start with ours though. What is it and how big a health challenge? Does it represent about half a million people. Every year get air F- Acute Respiratory Distress Syndrome in the United States alone. And you know close to two million. Maybe globally so it's it's not a uncommon Disorder But it is a extremely challenging to treat disorder because mortality of this. Anyone that had gets a yard is Thirty to forty percents In the US and it's probably higher Outside the US what makes it so challenging to treat? Well it's It's sort of the ultimate in inch in the stress to To a human being in that They have multiple attacks on a variety of Oregon starting with the lung though the the most common causes of ARD s are sepsis which is infection in the bloodstream and trauma and Smoking elation will do it and that Curiel and viral pneumonias and so as a result the starts off with inflammation in the lung from those particular Causes the inflammation becomes waves waves of amplify inflammation that starts to affect other organs. Like your kidneys and heart and ultimately patients with AIDS wind up. They don't survive. They die from that multi organ failure and that he's organs weren't able to sustain the inflammatory injury we've heard a lot about the respiratory challenges that can occur to people infected with the covid nineteen virus are the ones who end up on respirators suffering from arts and what role does arts play in the mortality of patients with Covid nineteen arches probably the primary cause of death in most of the cove in nineteen patients. At least that's what the the reports from China and elsewhere suggesting Covid NINETEEN INDUCE. Cards has a lot of similarities to garden variety area but it also has some unique changes that that may not be typical. Air S. as well and The ventilator Think this is an important part of the story. That patients with With Kobe nineteen viral infection or other causes of Respiratory distress like I mentioned substance or bacterial pneumonia trauma and you have Increasing respiratory distress your lungs. Start to fill with Lewis and the work of breathing when your lungs are. Our full of fluid is very very rate. So these patients generally run out of Energy the fatigue and they need then later to help with their respiration and so the the the the irony of of this is that the ventilator while saving your life because your new patients for an out of energy agreed on their own then later also the major cause for information as well. That's been known for now sometime and so strategies to address a yes whether it's cove nineteen induced or otherwise need to take into account the fact that then later contributes to that inflammatory burden patients with they as an academic. You've done functional genomics work that identified candidate genes that contribute to inflammatory disorders. Such as arts this led to a focus on the NAP. Jean what is Napkin? And what role does it play in the inflammatory cascade? Yes well that's That's exactly right. Dan we Early on when I was a cheap home area at Johns Hopkins the New Year early. Two thousands we are group there. through clinical trials that was published in the New England Journal in this clinical. We identified the fact that the later contributed some mortality in they already s and and the hypothesis was that the way that Ben later contributes mortality. It was it was causing excessive increases in inflammation so at that point my laboratory My Research Laboratory at Hopkins we We've again focusing very Aggressively on trying to identify genes. That might be involved in. How the ventilator induced that inflammation and This is how we found that gene. That's called NAM. Nam stands for nicotinamide Fossil Rizal Transfer. A is a protein that has a normal function inside the cell. But when it's secreted from the cell floats in the bloodstream. It is a very potent planetary mediator. And the reason we think NANCE's A pretty novel target for then later induced lung injury and they are s in general including cove in nineteen induced area. Is that this. Gene is induced very early. It's one of the first genes induce patient or a animals exposed to Mechanical Ventilation is this unique to the lungs or is this across inflammatory conditions. Well That's a great question The that is induced by many different stimuli in the lung. The event is the cause of Nancy to secreted hype poxy A- me low concentrations of of oxygen in the blood. So that could occur in any Oregon. If the if the person is low on oxygen in the blood politics that is a stimulus for more NAM secretion and You know other inflammatory stimuli and In in can cause an increase in NAM PRODUCTION. As well so it's not unique to the lung but the lung When you have These inflammatory mediators released because Nance's induced the expression of a lot of these mediators. The mediators cause inflammation and part of inflammation is leaking. Blood vessels the blood vessels become leaky during inflammation. So you can see in the lung. Which has the largest blood vessels system in the body the largest surface area of blood vessels when you have leaky blood vessels in the long? It's catastrophic strategic and that's what causes the lungs blood.

Respiratory distress Akwa Lung Therapeutics Aqua Lung Therapeutics Acute Oregon Joe Garcia NANCE United States Gene Covid founder and CEO nicotinamide Fossil Rizal Tran researcher Biotech Company bacterial pneumonia New England Journal Curiel China Lewis
"akwa lung therapeutics" Discussed on The Bio Report

The Bio Report

04:46 min | 1 year ago

"akwa lung therapeutics" Discussed on The Bio Report

"As a researcher Joe Garcia Applied Functional Genomics to understanding genes that contribute to inflammatory disorders such as acute respiratory distress syndrome or arts as founder and CEO of the Biotech Company. Akwa Lung Therapeutics. He's working to advanced therapies to hit these novel targets to treat unchecked inflammation with the company's lead experimental therapeutic candidate targeting arts. We spoke to Garcia about the company's arts. Therapy how it works. And why it's time we focus given the cove nineteen pandemic Joe. Thanks for joining us. To be here thing we're going to talk about Aqua Lung Therapeutics Acute Respiratory Distress Syndrome or arts and your efforts to develop a treatment for this condition. Let's start with ours though. What is it and how big a health challenge? Does it represent about half a million people. Every year get air F- Acute Respiratory Distress Syndrome in the United States alone. And you know close to two million. Maybe globally so it's it's not a uncommon Disorder But it is a extremely challenging to treat disorder because mortality of this. Anyone that had gets a yard is Thirty to forty percents In the US and it's probably higher Outside the US what makes it so challenging to treat? Well it's It's sort of the ultimate in inch in the stress to To a human being in that They have multiple attacks on a variety of Oregon starting with the lung though the the most common causes of ARD s are sepsis which is infection in the bloodstream and trauma and Smoking elation will do it and that Curiel and viral pneumonias and so as a result the starts off with inflammation in the lung from those particular Causes the inflammation becomes waves waves of amplify inflammation that starts to affect other organs. Like your kidneys and heart and ultimately patients with AIDS wind up. They don't survive. They die from that multi organ failure and that he's organs weren't able to sustain the inflammatory injury we've heard a lot about the respiratory challenges that can occur to people infected with the covid nineteen virus are the ones who end up on respirators suffering from arts and what role does arts play in the mortality of patients with Covid nineteen arches probably the primary cause of death in most of the cove in nineteen patients. At least that's what the the reports from China and elsewhere suggesting Covid NINETEEN INDUCE. Cards has a lot of similarities to garden variety area but it also has some unique changes that that may not be typical. Air S. as well and The ventilator Think this is an important part of the story. That patients with With Kobe nineteen viral infection or other causes of Respiratory distress like I mentioned substance or bacterial pneumonia trauma and you have Increasing respiratory distress your lungs. Start to fill with Lewis and the work of breathing when your lungs are. Our full of fluid is very very rate. So these patients generally run out of Energy the fatigue and they need then later to help with their respiration and so the the the the irony of of this is that the ventilator while saving your life because your new patients for an out of energy agreed on their own then later also the major cause for information as well. That's been known for now sometime and so strategies to address a yes whether it's cove nineteen induced or otherwise need to take into account the fact that then later contributes to that inflammatory burden patients with they as an academic. You've done functional

Respiratory distress Akwa Lung Therapeutics Aqua Lung Therapeutics Acute Oregon Joe Garcia NANCE United States Gene Covid founder and CEO nicotinamide Fossil Rizal Tran researcher Biotech Company bacterial pneumonia New England Journal Curiel China Lewis
Why An Experimental Therapy for Inflammatory Disorders Could Help the Fight Against COVID-19

The Bio Report

04:46 min | 1 year ago

Why An Experimental Therapy for Inflammatory Disorders Could Help the Fight Against COVID-19

"As a researcher Joe Garcia Applied Functional Genomics to understanding genes that contribute to inflammatory disorders such as acute respiratory distress syndrome or arts as founder and CEO of the Biotech Company. Akwa Lung Therapeutics. He's working to advanced therapies to hit these novel targets to treat unchecked inflammation with the company's lead experimental therapeutic candidate targeting arts. We spoke to Garcia about the company's arts. Therapy how it works. And why it's time we focus given the cove nineteen pandemic Joe. Thanks for joining us. To be here thing we're going to talk about Aqua Lung Therapeutics Acute Respiratory Distress Syndrome or arts and your efforts to develop a treatment for this condition. Let's start with ours though. What is it and how big a health challenge? Does it represent about half a million people. Every year get air F- Acute Respiratory Distress Syndrome in the United States alone. And you know close to two million. Maybe globally so it's it's not a uncommon Disorder But it is a extremely challenging to treat disorder because mortality of this. Anyone that had gets a yard is Thirty to forty percents In the US and it's probably higher Outside the US what makes it so challenging to treat? Well it's It's sort of the ultimate in inch in the stress to To a human being in that They have multiple attacks on a variety of Oregon starting with the lung though the the most common causes of ARD s are sepsis which is infection in the bloodstream and trauma and Smoking elation will do it and that Curiel and viral pneumonias and so as a result the starts off with inflammation in the lung from those particular Causes the inflammation becomes waves waves of amplify inflammation that starts to affect other organs. Like your kidneys and heart and ultimately patients with AIDS wind up. They don't survive. They die from that multi organ failure and that he's organs weren't able to sustain the inflammatory injury we've heard a lot about the respiratory challenges that can occur to people infected with the covid nineteen virus are the ones who end up on respirators suffering from arts and what role does arts play in the mortality of patients with Covid nineteen arches probably the primary cause of death in most of the cove in nineteen patients. At least that's what the the reports from China and elsewhere suggesting Covid NINETEEN INDUCE. Cards has a lot of similarities to garden variety area but it also has some unique changes that that may not be typical. Air S. as well and The ventilator Think this is an important part of the story. That patients with With Kobe nineteen viral infection or other causes of Respiratory distress like I mentioned substance or bacterial pneumonia trauma and you have Increasing respiratory distress your lungs. Start to fill with Lewis and the work of breathing when your lungs are. Our full of fluid is very very rate. So these patients generally run out of Energy the fatigue and they need then later to help with their respiration and so the the the the irony of of this is that the ventilator while saving your life because your new patients for an out of energy agreed on their own then later also the major cause for information as well. That's been known for now sometime and so strategies to address a yes whether it's cove nineteen induced or otherwise need to take into account the fact that then later contributes to that inflammatory burden patients with they as an academic. You've done functional

Respiratory Distress Aqua Lung Therapeutics Acute Akwa Lung Therapeutics Joe Garcia Biotech Company United States Curiel Covid Founder And Ceo Researcher Oregon Bacterial Pneumonia China Lewis Kobe