COVID-19 Question Answer Session with Dr. Amy Baxter

Outcomes Rocket


So let's chat cove in nineteen. You know what what? What are some of the myths out there that you want to help us bus than you know? Guide us through that. Sure well I think the scariest myth was one. That was introduced to me by my bank teller. I put on a mask. She had on a mass. And we've known each other for years and she said confidentially. Is this really a thing? Because I've got a friend in Brooklyn says he drives by the hospitals in no one's there. Is this really happening? So the biggest myth is that coveted is not a serious disease that it's the same as flu. A study. This week showed that there actually are twenty one times more fatalities from Kobe in New York were from flu so the biggest Smith is is this going way and is is really a thing and the answer is no and yet Yeah no I. I definitely appreciate that. And it's real you know and a lot of us in the healthcare space Definitely feel it but there might be that out and so as we as we think about it. You know What what are some of the questions year getting and seeing that that you feel? The listeners could benefit from knowing around the around this virus. Sure I think that the interesting things are how this virus is different from other viruses and some of those attributes we could leverage for treatments and for care and some of them may get really scary because we don't have One of the papers I read yesterday said this virus is unlike any other and I think it's true. This pathogen is doing things that other viruses haven't so first of all the biggest difference is in infectivity by age. Usually we have what we call A. You're a where the very young ages we have a lot of infections in morbidity which means bad things happening and at the old ages we have a lot of corporate entity mortality. And we don't see that this one is very much a a along J. It's very very low. At young ages goes way at the top other than it. Strange about. This is how long it takes to become infected and how precipitous drop is when people have a problem so. I think that you probably know that. From the time of infection until you show symptoms can be five to seven days so that incubation is very long the scary part is that forty four percent of infections come during that a symptomatic face. So it's very easy to spread without knowing you have it. Which makes it harder to track. Hard to trace and hard to know who detest. Yeah it's It's different and and so how about the ideas of like where it came from and and you know why any thoughts around that sure well. It turns out that bats are natural reservoirs of grunted irises. So for example a Bola was initially in a bat in a cave. That a young boy outside the incident town was playing with. And that's where the virus team from as habitats change as the climate changes. Bats go out of their normal territories and they happen to have grown viruses as a very common infection. It doesn't kill them so it can be transmitted directly to humans now. The certainly the time that this virus started wasn't Wuhan an was from a back but it looking at the strains and the genetic typing of it it seems to be mutating fairly slowly and it makes it very easy to see when it started where it came from so the wet market in China is still the most likely it came from but no matter what. This is. The kind of virus that comes from that directly to humans. I'd heard that and I wasn't sure if it was true or not. I'm like is it. Is it really from Batson mean and then I also hear people saying it came from a lab somewhere? It's a chicken egg thing or a Atlantic yet. There was a there is a lab in Wuhan because of the risk of corona viruses. It had been studying. Bats heavily said SARS and Moore's so both stars and moons are Corona viruses and there had been increased studying bats in that lab. But it's because they're dangerous and because there are risks not because they're trying to create run irises or create infections. It's the fact that somebody was looking at it in researching yet because it was dangerous not that it became dangerous because someone was researching fascinating fascinating. I didn't know that connection. Thank you for that. So as we as we explore this J shaped curve. You know. I'm curious right. I mean I've got a three year old and I've got you know aging parents will tell me more about that and and particular things that you'd recommend for safety and and You know just things that we need to keep on our mind share it. Will I have a couple of theories about why the J shaped curve is typically the U shape curve has to do with mutagenicity so how well your immune system protects you and young? People don't have very weldon alter union systems so they tend to be more vulnerable to respiratory diseases and older people also have decreased immune systems so the the very heavy incidents on people who are over sixty five which seems to be where the cutoff is to have a dramatic increase in risk. That probably isn't due to decreased. Immunity one of the theories is that due to increased immunity. That there were the two grown viruses virus alpha and Beta cuddling named that were circulating in the late fifties and identified sixties. And so it may be that those people were alive in the fifties and sixties before it. Kinda petered out has some immunity that was developed that point which causes an excessive immune response in older patients. Now the other possibilities are this. Virus doesn't seem to enter the body and then get into the bloodstream and spread everywhere. It seems more like this virus comes into the body and marches a bit at a time. Almost as if the the troops come in and they set vacations and it's like World War Two and so the battalion's multiply and spread on a time. So with that being the case the interesting thing is that paper nature last week determined that tissues that this viruses attaching to before the lipid fatty layer of the virus. Fuses with the cell. Can the news in the nose? There's something called an ace two receptor. That is where the little spiky protein hops onto and holds on and their ace two receptors. All over the body but the ones that were interested in the nose and children don't have big noses they also don't have sinuses. You don't get a false at sinuses teenager interesting so because of that. Maybe that's why they they're less less at risk to to get this. Yeah absolutely if what we're talking about is something called viral load which is literally hell many virus particles. You have That is going to be difficult to accumulate in a small child. One of the interesting things I found out was that the nasal cavity size is dramatically. Increased over the age of seventy and it's Moammar nails. Oh is that right. Yeah certainly we've seen that males can be more at risk of catalyses more at risk of catching the virus than females. The ratio is about five to three some studies on about sixty percent of males. Were the ones who are affected by an only forty percent cements

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