A highlight from Prof. Emery Brown, Professor of Anesthesia at Harvard Medical School and Computational Neuroscience at MIT


He slapped develop statistical methods and signal processing algorithms for euro science data analysis. Malcolm henry thanks for having me go. Thanks for doing this. i understand. we're going to get older papers. General anesthesia and altered states of arousal is stems science So you say placing a patient in a state of gentleman. Stiches crucial for safely and dak humanely performing most surgical admitting your surgical procedures how anesthetic. Drugs created the state of gentlemen stay. She has considered me to misery. Modern medicine unconsciousness induced by auditor. Also add or commission is perhaps the most fascinating behavior state of telling the speech here I done this only once. Emory and it was lightning right so So there a lot of different types of chemicals of the typically use combinations of them and obviously there are many many different surgical procedures of the direction of this procedure is quite. We'd so watch the state of the art in Today right that's a good question. That's an intro to paper. That i wrote basically ten years ago and and and i think one of the things that we figured out in the last in that time period is little more insights into like. What's going on in the brain under anesthesia. And i think that we can. We can use those ideas that understanding to make further improvements so just to just to explain a little bit so we have different categories of drugs that we used to create the state of general amnesties. So i let me just give you. A definition with general anesthesia is has about four component. So you're unconscious. You're not proceeding paying. You're not going to remember anything that's going on and you're not moving so the disease. The surgeons operate and this is done using drugs. And it's reversible so we bring you in we bring you out and all that we keep physiologic stability so we watch your heart rate your blood crushing saturation body temperature. So that's general anesthesia. that's that's the description of it and he's burma nations of drugs to do that. All right so you know one. We may use one drug to help to put you into the state another combination of drugs to help basically like like maintain the state. So so you're you're in a state. Where essentially insensate to what's going on in the outside world and as i suggest that there you have to be in a state like that in order to tolerate what would otherwise be a traumatic event. They're going to like maybe do. Heart surgery do abdominal surgery. That sort of thing. So so so that that's a that's a requirement if you saying the conditions that i just described so so so then the the high level statement which i think sorta can maybe help orient. The thinking of people. Is that the drums act in the brain. And was they act in the brain. They caused the brain circuits. That connections between the various parts of the brain that generate current oscillations is a right now. There's current flowing our brains. I'm talking to you as you're listening to me. And that current flow represents the activity of the brain you know processing information carrying on are the functions in our daily lives. What the anesthetics thursday hijacked those circuits and they control the circuits so they produce large oscillations and these these large isolations are actually one of the what we think are probably one of the primary were. These drugs are producing the states of altered. Arousal make your unconscious or making make it possible for you not to perceive pain and as long as you keep drugs. They're these oscillations. Are there and then when you turn them off the the subside and you come to could you You could give some so you say. The authored states of arousal sedation. Unconsciousness session An disassociate of anesthesia pharmacology known rem sleep and noodle left the station so so these thousands of dacians all unconsciousness or Holidays competence lineup in in hierarchy.

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