How does a pet get cloned?


Cloning how does that get cloned so the very first step if you are thinking you might potentially you want to call on your pet Sunday that first step is our genetic preservation service and what that involves is a veterinarian taking a few small skin biopsy samples from your pets and if you're planning in advance and it is best to have these biopsies done while the cat is still alive and healthy so if you're planning in advance it's best to order I biopsy kit and we can ship this biopsy can overnight to the veterinarian or to the client and this biopsy kit has everything that the veterinarian needs to take the samples and to ship them to us at the appropriate temperature so it's just a small four millimeter punch biopsy at the skin so very simple every veterinarian the world is that a punch biopsy before so very easy to do it can be done with the local anesthesia or it can be done under general anesthesia if you are planning in advance in the veterinary purse first to do a general anesthesia then you might consider having this done in conjunction with a dental cleaning something like that where the the dog is already under anesthesia so we have a lot of clients that she used to do it at that time so the the vet takes a biopsy samples very small and very minimally invasive or the pet and would like to have anywhere from to try by an overnight with the return and ex label that included in from these tissues are they going to sell culture and we will grow millions of cells that contain that had DNA and the cells will ultimately be the starting point where the cloning process that is absolutely amazing it really sounds like Jurassic Park so hope is it possible to do Jurassic Park dinosaurs are we just doing cats and dogs I should ask what species can be cloned so there are quite a few species clones Bijan pets was originally part of the company that cloned livestock so cattle pigs goats and sheep have been cloned over the past seventeen years and when we began and by Jim Henson equine we now just clone dogs cats and horses so those are the three species that we clone and weeping cloning courses for about seventeen years and dogs and cats for about almost four years and it's it's going very well the cloning is just growing and growing the more people find out about this and then it's a possibility it's really a growing field with cloning I think a lot of people have concerns and I had a lot of questions because it's not as a topic that was really broached when I was in veterinary school so with cloning I know that Dolly the sheep seem to be healthy land a shorter lifespan than a typical sheep of that particular breed what happens for a dog and a cat is there or horse is there a lifespan basically the same physical issues they have can a brief for instance yes all very good questions so in going back to Dolly the sheep the technique that we use for cloning is essentially very much the same as what was used for Dolly many years ago and it is technically called somatic cell nuclear transfer or S. T. and T. so a somatic cell is any cell in the body that's anything other than a sperm or an egg and for dogs and cats and horses the somatic cells all these are what we grow in the culture from the skin biopsies taken from the pet so that somatic cell is that source at the beginning so that process is essentially the same and how the embryo is made and all of the species is how we use that egg from a donor animal and we removed the nucleus of that egg and we transfer in one of the somatic cells from the skin sample and these agonist cell are now fused together in an embryo starts to grow and then we'll transfer that embryo into the surrogate animal for dogs and cats they're a little bit different than the worst because dogs and cats are litter bearing species so we do transfer multiple embryos into that surrogate mom so is there is that chance that there could be twins or triplets said usually small number of puppies or kittens in the later but that is a chance and usually the clients will take as many as are born in the letter and it's just the one let me go back to your question about the longevity of these animals so Dolly did live a shorter lifespan than normal and so there was speculation at the time twenty two years ago that this was because she was a clone animal there's been a lot of research done on cloned animals and stating their longevity and their health over the years and cloned animals have been shown to live a normal lifespan which is really refreshing for a lot of these pet owners because unfortunately Dolly kind of got a bad rap and because she did let us our lives so it is you know it's the sort of the myths surrounding cloning that cloned animals live a shorter lifespan than an average animal and that's simply not true so cloning animals have been shown to live a normal lifespan and should be just as healthy as the original animal now one question that we do get quite often is let's say you know the the original all dog developed cancer will the cloned dog develop cancer great yes that's comes right on it and the answer is it depends on the cause of that cancer so which we don't veterinarians don't usually no it's not really definitive what the causes of most cancers are but if it was something that was shown to be genetically linked type of disease or illness the net cloned animal is going to have those same genes so that same potential to develop that disease at some point in its life it's not automatically going to develop that disease but that potential is there so sometimes the client can know to watch out for symptoms they may see them earlier and your because they're looking a little more closely for them where there may be some diagnostics that can be done on the Pat to to make sure that this does not developing that disease that the original Pat may have had that should have just the same longevity and health status as the original animal so genetic counseling especially the situation like that because you say are and I have a golden retriever and this golden retriever died of a type of cancer and then she'll star coma but this is just the best dog in the entire world so I want another one just like Goldie and then there is that chance because of the genetic predisposition that the next at could have cancer also said that yes I think it's very important so Mylene you were talking about this genetic preservation that can go on and you'll sometimes have a cloned animal in Sir get that you may have three or four are they obligated to take all the pattern that later and if not what do you do with the other pets and I'm sure people are thinking how many cats and dogs and horses do they have to act to circuits so our litter sizes are usually small just one or two maybe three and puppies or kittens and the letter we did have some larger sizes we had up to five puppies in a litter and this is sort of earlier on in the cloning process when we were at yeah and it's fine tuning in the number of embryos that go into the store get to get the number of puppies or kittens that we're hoping for and most clients will only want just one or maybe two so yeah I can understand work five is a lot to handle so he we do sort of try to treat that but you never know it's kind of like IVF you may end up with twins or triplets and it's just a little bit of a risk that may be there I would say most clients if there are three parties let's say most clients are going to say yes I want every single copy that morning that's completely understandable I know I would end up actually I have my dogs those prisoners I've already talked to my family and that's it okay on my dog Zeus and there's three puppies I'm gonna take one and again my brother you'll take one right and my mother worked I'm gonna give you that so it within my family so I can keep an eye on them and I and that's what most clients will choose to do is is a date they may not keep every single one of them somewhere else but if there's more than they can really take care of it solely on three copies as a lot then they may Debbie does that now I have the claim is not obligated to you take every every cut your kitten that's born with the cloning agreement and they are guaranteed at least one healthy puppy or kitten they're not obligated to take any extra ones there's of course no additional fees for those extra puppies or kittens so in we've had a couple clients that have have said you know I can only take two can you find a good home for these other you know we do have the other ones and we've done that we haven't really get adoption program in the cases that we've done that before those copies of actually been adopted out to you our own employees so it makes it really nice because the the clients can keep tabs on those and they know that the copies went to again how so you have the genetic preservation I want to have the biopsies done small really not painful I agree with you doing little four millimeter biopsies with local anesthesia is so simple you can plan have that preserved how long can you preserve it so if somebody says you know this is really good dog I'm not really sure if I want to do this what's going to be going on later on my life how long can that genetic material be stored and how is it stored I mean I would say most of our clients are are wanting to just preserve the cells are now and it cost is quite a lot where the cloning itself so those clients are just holding on to that DNA we preserve the cells the cells and the cell culture that we do it takes about two to four weeks to complete the culture and then these cells are placed in a crowd files with a crow protected media and they're stored in liquid nitrogen tanks in the cells can be kept stored essentially for ever for decades and we have clients that have stored cells S. for seventeen years and we've actually called a couple of dogs in at least one cat who sells were stored for seventeen years and then they they contest that later on so it's really amazing so essentially forever the cells can be stored there is an annual storage fee for storing cells so they the initial cost of the genetic preservation in sixteen hundred dollars and that includes culturing the cells in the biopsy kit shipment to and from the veterinarian and that also includes the first year of self storage after the first year the annual storage fee is a hundred and fifty dollars per year in the great thing about this is all of the up front fees that the client pays for the preservation and any subsequent storage fees these all get combine an addict gather and then when they decide to clone down the road everything that they've paid to date gets applied toward the cloning so long term clients really like that so I think this is a fascinating way that you're doing this Mullane where you are saving the cells your happiness fee but then you're not being hit with additional fees you know way on top of that because you're paying for a little bit little all the way along that's great now again you are saving the cells it's not embryos because oftentimes we hear about in human medicine where they're saving this genetic material but you're actually saving embryos is that correct that's right for the genetic preservation work we haven't created the embryos just yet they're actually for pets there is not been a technique developed to be able to freeze embryos we can do that and horses so because we've been cloning horses for so long we have improved the technique and initially there was when we first started doing this there was no process available to successfully resent all embryos for horses but now we've developed these techniques we have some of the top cloning scientist in the world on staff your just amazing and so for horses that is our standard thing that we do with the cloning is we we create the cloned embryos and then they are frozen and then they can be shipped and in transferred into their reset mayor at that point but for dog and cat it has to be a fresh embryo so we don't create embryos just yet we just up from genetic preservation we're just simply producing the

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