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Why An Experimental Therapy for Inflammatory Disorders Could Help the Fight Against COVID-19



Joe. Thanks for joining us. Joe. Thanks To be for here joining thing us. we're going to To talk be here about thing Aqua Lung Therapeutics we're going to talk about Acute Aqua Respiratory Lung Therapeutics Distress Syndrome Acute or arts Respiratory Distress and your Syndrome efforts or to arts develop a treatment and your for efforts this condition. to develop a treatment Let's for start this condition. with ours though. Let's What start is with it ours and though. how big What a health is challenge? it and how Does big it represent a health challenge? Does it represent about half a million people. about Every year get half air a million people. F- Every Acute year Respiratory get Distress air Syndrome F- Acute Respiratory in the Distress United States Syndrome alone. And in you know the United close States to alone. two million. And Maybe you know globally close to two million. so it's Maybe globally it's not a so uncommon it's it's not a uncommon Disorder Disorder But it is a extremely But it is challenging a to extremely treat disorder challenging because mortality to treat of this. disorder because mortality Anyone that of this. had gets a yard Anyone that had is gets Thirty a yard to forty percents is In Thirty the US to forty and percents it's probably In the higher US and it's probably Outside the US higher what Outside makes the it US so challenging to what treat? makes it so challenging Well to treat? it's It's sort Well of the ultimate it's in inch It's sort of in the ultimate the stress in to inch in the To stress to a human being To in that a human being They have in that multiple They attacks have on multiple attacks a variety of on Oregon a starting variety with of the Oregon lung though starting the the most with the common lung causes of though ARD the the s most are common causes sepsis of ARD which is s infection are in sepsis the bloodstream which is infection and trauma in the bloodstream and and trauma Smoking and elation will do it Smoking and elation will do that it Curiel and and viral pneumonias that Curiel and so and viral as pneumonias a result the and starts so off as with a inflammation result in the the lung starts from off those with inflammation particular in the lung from those Causes particular the Causes inflammation becomes the waves inflammation waves becomes of amplify waves waves inflammation of amplify that starts to affect inflammation other organs. that starts Like to your kidneys affect and heart other organs. Like and your ultimately kidneys and patients heart with AIDS and wind ultimately up. patients They with don't AIDS survive. wind up. They die from They that don't survive. multi organ They failure die and from that that multi he's organ organs failure and that weren't he's able organs to sustain the weren't able inflammatory to sustain injury the we've inflammatory heard a lot about the respiratory injury challenges we've heard that a lot can about occur the respiratory to people challenges infected that can occur with the to covid people nineteen infected virus with the are covid nineteen the ones virus who end up on are respirators the ones suffering who end up from on respirators arts and suffering what from role arts does arts and play in what the role mortality does arts of play patients in with the mortality Covid nineteen of patients with Covid arches nineteen probably the primary arches probably cause the primary of death in most cause of the cove in of nineteen death patients. in most of At the least cove in nineteen that's what patients. the the At least reports from that's China what the and the elsewhere reports suggesting from China and elsewhere suggesting Covid NINETEEN INDUCE. Cards Covid NINETEEN INDUCE. has a Cards lot of similarities to has a garden lot variety of similarities area to garden variety but it area also has some unique but it also changes has some that unique changes that may that not be typical. Air that may not S. as be well typical. Air and S. as well The ventilator and The ventilator Think this is an important Think this part is an important of the story. part of the That story. patients with That patients With Kobe with nineteen viral With infection Kobe nineteen or viral other causes infection of or other causes Respiratory of distress like I mentioned Respiratory substance or distress bacterial like I pneumonia mentioned substance trauma or bacterial and pneumonia you have trauma Increasing respiratory and you have distress Increasing respiratory your lungs. Start distress to fill with Lewis your lungs. Start to and fill with Lewis the work of breathing and when your the work lungs are. of breathing Our when full of your fluid lungs is are. very very Our full of fluid rate. is very very So these patients rate. generally run So out of these patients generally Energy run out of the fatigue Energy and they need then the fatigue later to help and they need then with later their respiration to help with and their so respiration the the and the so the the the irony the of of the this is that irony the ventilator of of while saving this your is life that the ventilator while because saving your your life new patients for an out because of your energy new patients agreed on for an their out own of energy agreed then on later their own also the major then later cause also for information the major as well. cause for information That's been as known well. for now sometime That's and been known for so now strategies sometime to and address so strategies a yes to whether it's address cove nineteen a yes induced whether or it's otherwise cove nineteen induced need or to take otherwise into account the fact that then need later to take contributes into account to that the fact inflammatory that then later burden contributes patients to that with they inflammatory burden patients with they as an academic. You've done functional as an academic. You've done functional genomics work that identified candidate genes that contribute to inflammatory disorders. Such as arts this led to a focus on the NAP. Jean what is Napkin? And what role does it play in the inflammatory cascade? Yes well that's That's exactly right. Dan we Early on when I was a cheap home area at Johns Hopkins the New Year early. Two thousands we are group there. through clinical trials that was published in the New England Journal in this clinical. We identified the fact that the later contributed some mortality in they already s and and the hypothesis was that the way that Ben later contributes mortality. It was it was causing excessive increases in inflammation so at that point my laboratory My Research Laboratory at Hopkins we We've again focusing very Aggressively on trying to identify genes. That might be involved in. How the ventilator induced that inflammation and This is how we found that gene. That's called NAM. Nam stands for nicotinamide Fossil Rizal Transfer. A is a protein that has a normal function inside the cell. But when it's secreted from the cell floats in the bloodstream. It is a very potent planetary mediator. And the reason we think NANCE's A pretty novel target for then later induced lung injury and they are s in general including cove in nineteen induced area. Is that this. Gene is induced very early. It's one of the first genes induce patient or a animals exposed to Mechanical Ventilation is this unique to the lungs or is this across inflammatory

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