Alzheimer's Disease, Alzheimer Disease, Assistant Professor discussed on People's Pharmacy


Times more effective than penicillin. So it's a pretty potent little protein. But the really interesting thing about it is how it does that and the way it does it is it foams employed and traps the bugs. So literally encapsulates and permanently sequester them into these amyloid deposits, which we call plucks amyloid plaques, which you find in huge abundance in Alzheimer's disease. Patient's doctor. Quite kind of bugs. Are there in the brain? Yeah. So that's obviously a question. And the sort of a knee-jerk interpretation of finding is that Alzheimer's disease must be some sort of fiction. That's not as outrageous as it sounds. This being a a small group of people saying that for many years, and indeed, if you'd talk to people before the discovery of I buy, most of the idea researches would have said it isn't fiction, and fact Ellis Alzheimer's. The first guy to suggest it. But the thing is it's a little bit more complicated than that because there's no single pathogen that crops up in every day case. So it seems that it's not so much a classical in fiction as possibly a combination of microbial organisms causing this problem. So of about eight months ago, we started what we've called the brain micro. AM project. So we've been looking in Brian's to see what's there. We do with the process called Jeep in genomic sequencing, which basically involves looking at deny and looking for non human sequences and the findings were both very surprising and very exciting. We found over two hundred twenty bacteria that seemed to be living regularly in normal people. That's extrordinary. I think that if you had asked most patients and perhaps most health professionals twenty years ago, are there bugs in our brains. Microbes bacteria, viruses, fungi stuff like us, the micro ecology of the brain look like, I think people would have given you a blank stare. So you know the brain is sterile there. There's nothing growing in there just as we used to think the lung with sterile. In fact, except for our digestive tracts, the colon, we thought, you know, the body is pre devoid of stuff pathogens, but you're saying you found two hundred and twenty different bacteria in the brain indeed. And the whole concept of the stereo buddy is kind of studying to to fight away. There's a microbiome of the blood in every Mila blood is about a thousand microbes. And as far as the Bryans consent, people knew for quite a while that there was a various populations in if for instance, viruses, the number of ours is particularly hoop. He's viruses. That pretty much one hundred percent of people have hippie. Six. A lot of people have hippies one. They usually acquire them before the age of two their lifelong. So the him as it's known has been known about for quite a while and this probably a dozen or so it tends out this more than a dozen, but that's been known for quite some time. Plus this took place. Melissa, of course, the little amoeba would so that system I did the being one in every five people. It's normal host is the cat, but it's found its way into us. And so you know, there's Ivor billion people on the planet, but that thing living in neighboring. So it's not exactly strictly sterile, but I don't think it was appreciated just how many different microorganisms. So there seems to be living in a bright and they're not just sitting there doing their own thing, the interacting, and you can do an analysis that looks. Those sort of interactions. And what it tells us is that sometimes they co up right sometimes they compete. They really an active microbiome and not just passive resistance. You're listening to Dr Moy assistant professor in urology at Harvard Medical School. He's also assistant professor neurology at Massachusetts General Hospital neurology research, Terry, it's unbelievable. I mean, I'm just amazed that we have so many different bacteria and viruses in our brains more than two hundred different types of bacteria from healthy people. And there's just been a study published several weeks ago suggesting that herpes six and herpes seven viruses may be implicated in Alzheimer's disease. Well, the levels of those viruses were twice as high in the brains of people with Alzheimer disease as they are in healthy individuals. So. So it doesn't say it's causing affect, but it certainly looks suspicious end. It looks as if people who have evidence of those infections may have a faster decline. So it may be interacting in some way to cause problems in the brain. Well, after the break, we're gonna find out what those microbes are doing in our brains. Is it possible to have a beta amyloid and those tau tangles, but not dementia? What makes brains of Alzheimer's disease patients so different from others? Is it possible to correct the microbiome balance in that brain? Could we get rid of the bad actors boost the beneficial ones? Learn how this research could help in preventing or reversing dementia. You're

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